Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	A/G_cyclase_CS	NPR1 ADCY5	1.52e-03	17	64	2	IPR018297
Domain	Nucleotide_cyclase	NPR1 ADCY5	1.71e-03	18	64	2	IPR029787
Domain	-	NPR1 ADCY5	1.71e-03	18	64	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	NPR1 ADCY5	1.90e-03	19	64	2	PS00452
Domain	Guanylate_cyc	NPR1 ADCY5	1.90e-03	19	64	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR1 ADCY5	1.90e-03	19	64	2	PS50125
Domain	A/G_cyclase	NPR1 ADCY5	1.90e-03	19	64	2	IPR001054
Domain	CYCc	NPR1 ADCY5	1.90e-03	19	64	2	SM00044
Domain	Quino_amine_DH_bsu	WDR6 FSTL4	2.55e-03	22	64	2	IPR011044
Domain	Kringle-like	PRSS12 MMP2	5.37e-03	32	64	2	IPR013806
Domain	-	WDR6 WDR87 RPTOR FSTL4 WDR18	5.64e-03	333	64	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR6 WDR87 RPTOR FSTL4 WDR18	5.79e-03	335	64	5	IPR015943
Domain	UBA	RNF31 HUWE1	6.76e-03	36	64	2	PF00627
Pubmed	Interaction of CpG-oligodeoxynucleotides with Toll like receptor 9 induces apoptosis and modulates metaloproteinase-2 activity in human intestinal epithelium.	MMP2 TLR9	3.66e-06	2	67	2	17893430
Pubmed	Effects of Oncostatin M on Invasion of Primary Trophoblasts under Normoxia and Hypoxia Conditions.	OSM MMP2	1.10e-05	3	67	2	30091322
Pubmed	Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.	RELN ZBTB20	1.10e-05	3	67	2	17360894
Pubmed	The effects of oncostatin M on trophoblast cells: influence on matrix metalloproteinases-2 and -9, and invasion activity.	OSM MMP2	1.10e-05	3	67	2	22931588
Pubmed	Differential interaction of the Pafah1b alpha subunits with the Reelin transducer Dab1.	RELN PAFAH1B2	2.19e-05	4	67	2	19272360
Pubmed	Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.	RPTOR PREX1	3.64e-05	5	67	2	21339740
Pubmed	mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1.	RELN RPTOR	5.46e-05	6	67	2	30271915
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ZBTB40 ALS2 CACNA1G ADGRA2 PREX1	7.55e-05	225	67	5	12168954
Pubmed	The Pafah1b complex interacts with the reelin receptor VLDLR.	RELN PAFAH1B2	7.63e-05	7	67	2	17330141
Pubmed	Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.	RELN ZBTB20	7.63e-05	7	67	2	17301088
Pubmed	Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.	RELN ZIC1	7.63e-05	7	67	2	8863127
Pubmed	P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.	RPTOR PREX1	7.63e-05	7	67	2	17565979
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MRE11 KMT2B STC2 RPTOR ZBTB40 HUWE1 STRIP1 MOCOS	1.19e-04	774	67	8	15302935
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	RELN ADCY5	1.63e-04	10	67	2	16615126
Pubmed	A prospective evaluation of left ventricular remodeling after inaugural anterior myocardial infarction as a function of gene polymorphisms in the renin-angiotensin-aldosterone, adrenergic, and metalloproteinase systems.	CYP11B2 MMP2	1.63e-04	10	67	2	17383306
Pubmed	The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway.	RNF31 RPTOR	1.63e-04	10	67	2	37081115
Pubmed	Gene targeting approaches to analyzing hypertension.	NPR1 CYP11B2	1.99e-04	11	67	2	10405217
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	KMT2B IMPDH2 WDR6 RPTOR WDR18 ALS2	2.44e-04	454	67	6	33226137
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MRE11 OSM PTPN14 RNF31 WDR6 RPTOR PANK4 GARRE1 PCID2	2.81e-04	1116	67	9	31753913
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	RPS27A HUWE1	2.81e-04	13	67	2	29285303
Pubmed	Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.	WDR6 PAFAH1B2	3.28e-04	14	67	2	22354037
Pubmed	HIV-host interactome revealed directly from infected cells.	IMPDH2 WDR6 TMEM131L HUWE1	3.47e-04	172	67	4	27375898
Pubmed	High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.	RNF31 HUWE1 TDRD12	3.71e-04	72	67	3	24270810
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	MRE11 RPTOR POLG ZBTB40	3.95e-04	178	67	4	27637333
Pubmed	UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b.	RPS27A HUWE1	4.31e-04	16	67	2	35980206
Pubmed	Armc5 deletion causes developmental defects and compromises T-cell immune responses.	ZBTB40 HUWE1	4.88e-04	17	67	2	28169274
Pubmed	Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice.	RELN ZIC1	4.88e-04	17	67	2	22578469
Pubmed	Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.	RELN ZIC1	5.48e-04	18	67	2	23817546
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	MRE11 KMT2B	5.48e-04	18	67	2	17500065
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MRE11 PTPN14 WDR6 AZU1 MTMR8 TMEM131L AKAP10 HUWE1	5.56e-04	974	67	8	28675297
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PTPN14 HIBCH LYPLAL1 WDR6 RPTOR POLG PANK4 RPS27A HUWE1 STRIP1	5.58e-04	1496	67	10	32877691
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	RPS27A TXNRD2 ADCY5 PCID2	6.01e-04	199	67	4	36688959
Pubmed	Identification of type 2 diabetes-associated combination of SNPs using support vector machine.	CYP11B2 CACNA1G MMP2	7.35e-04	91	67	3	20416077
Pubmed	Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation.	RELN ZIC1	7.50e-04	21	67	2	23404109
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	RELN HUWE1	7.50e-04	21	67	2	19686682
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	NPR1 KMT2B MMP2 ADGRA2	7.89e-04	214	67	4	22199357
Pubmed	Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury.	RELN ZBTB20	8.24e-04	22	67	2	29748916
Pubmed	TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.	RELN CACNA1G	8.24e-04	22	67	2	32675279
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	RELN ZIC1	8.24e-04	22	67	2	18448648
Pubmed	BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.	RELN ZBTB20	9.82e-04	24	67	2	36263009
Pubmed	An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.	RNF31 PAFAH1B2	1.07e-03	25	67	2	37589075
Pubmed	Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.	RELN ZIC1	1.07e-03	25	67	2	17507568
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	RPTOR HUWE1	1.07e-03	25	67	2	30340022
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KMT2B HUWE1 GARRE1	1.08e-03	104	67	3	9205841
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	IMPDH2 RPTOR PANK4 WDR18 ECEL1 HUWE1	1.11e-03	606	67	6	36538041
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MRE11 PTPN14 IMPDH2 RNF31 WDR6 RPTOR AKAP10 HUWE1 PCID2	1.12e-03	1353	67	9	29467282
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2B RPTOR POLG MTMR8 TXNRD2 HUWE1 ADGRA2 PREX1	1.26e-03	1105	67	8	35748872
Pubmed	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	MRE11 MMP2 TXNRD2	1.52e-03	117	67	3	19124506
Pubmed	Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons.	RELN FSTL4	1.54e-03	30	67	2	31399471
Pubmed	SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.	IMPDH2 WDR6 RPS27A	1.63e-03	120	67	3	37929963
Pubmed	Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.	PAFAH1B2 MMP2 TLR9	1.84e-03	125	67	3	19019335
Interaction	TRIM66 interactions	MRE11 PTPN14 WDR6 RPTOR PANK4 GARRE1 PCID2	3.87e-06	205	64	7	int:TRIM66
Coexpression	GSE34156_UNTREATED_VS_24H_TLR1_TLR2_LIGAND_TREATED_MONOCYTE_DN	HIBCH MAN1C1 ZBTB40 HUWE1 STRIP1 TDRD12	1.01e-05	196	66	6	M8685
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPGRIP1 RELN MAN1C1 ZIC1 DIPK2B	6.03e-06	174	66	5	4a18b51501eaaeb7907e99316ba8ae15b2c7d529
ToppCell	Mesenchymal_cells-Stromal_fibro.\|Mesenchymal_cells / Lineage and Cell class	RELN ZBTB20 TTC21A MMP2 ADCY5	7.30e-06	181	66	5	f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	NPR1 RELN MMP2 ADGRA2 DIPK2B	9.97e-06	193	66	5	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	NPR1 RELN MMP2 ADGRA2 DIPK2B	9.97e-06	193	66	5	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	OSM STC2 LMOD1 TDRD12	1.95e-05	107	66	4	5907b9632c88d48f293c3c6d37b7ef831fbcdd86
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)\|Striatum / BrainAtlas - Mouse McCarroll V32	OSM STC2 LMOD1 TDRD12	1.95e-05	107	66	4	d4807f008619dfd3e215d602df0d02b135b1ac37
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	OSM STC2 LMOD1 TDRD12	1.95e-05	107	66	4	3f24de1afbfd070f9db11c9acd02b90e5eb2511d
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAN1C1 POLG PAQR4 ZBTB40	2.86e-05	118	66	4	08bdf7bc3c9dcbc0f690658fe14e6cc4b9581698
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAN1C1 POLG PAQR4 ZBTB40	2.86e-05	118	66	4	3b077ad5c68c01b3fcc93f203cb130bb90705af9
Disease	cutaneous leishmaniasis (is_marker_for)	MMP2 TLR9	2.13e-04	10	65	2	DOID:9111 (is_marker_for)
Disease	squamous cell carcinoma (is_marker_for)	MMP2 TLR9	7.98e-04	19	65	2	DOID:1749 (is_marker_for)
Disease	ethylmalonate measurement	HIBCH LYPLAL1	8.85e-04	20	65	2	EFO_0020009
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	MMP2 TLR9	1.50e-03	26	65	2	DOID:0080998 (biomarker_via_orthology)
Disease	corpus callosum mid-anterior volume measurement	OSM GAL3ST1	1.62e-03	27	65	2	EFO_0010297
Disease	colorectal cancer	METRNL ZBTB40 LMOD1 MMP2 PREX1 GARRE1	2.13e-03	604	65	6	MONDO_0005575

Protein segments in the cluster

Peptide	Gene	Start	Entry
AQLICSGARRGMHAF	ACOX2	206	Q99424
CFQDNMRHGHGLLRS	ALS2	1126	Q96Q42
LCFHIAMTSAVFAGG	ADGRA2	811	Q96PE1
SHMEAAHFGDLGRSC	AKAP10	96	O43572
FHGHMCIAFELLGKN	CLK3	376	P49761
VLCNRAAFHQDHMGL	ADCY5	286	O95622
GMLFLHNGAICSHGN	NPR1	646	P16066
HIDAGMFGVFNNGHL	DIPK2B	291	Q9H7Y0
SLFLVAAHEFGHAMG	MMP2	396	P08253
RLSQACMRGHDFHEG	HIBCH	331	Q6NVY1
HAGEISFGGCLAQMF	OR52D1	91	Q9H346
RFTGRMLCAGNLHEH	PRSS12	801	P56730
SMGHKFSQRCGHLDG	MTMR8	376	Q96EF0
AMALTGGIGFIHHNC	IMPDH2	81	P12268
NHMTLACFHGPNFRS	KIAA1109	4661	Q2LD37
RFHNQRHICGGKTEM	LMOD1	421	P29536
VLGDAHFAGMHGCTA	POLG	901	P54098
RKHFQAGHVCGDNMD	MOCOS	441	Q96EN8
ATMHGNAARFINHSC	KMT2B	2641	Q9UMN6
FTGHMHFGEARLGCA	METRNL	271	Q641Q3
HLMLQKFLCSGGHNA	HUWE1	1151	Q7Z6Z7
CLGQANRHFGMALGA	ECEL1	441	O95672
SVLYHLFMCHQGGSA	PAQR4	96	Q8N4S7
SHARFVQFFMRLGCG	RELN	2221	P78509
MGRAVHTNYHAALRC	PANK4	726	Q9NVE7
MFAAHLRCTYAVGNH	PCID2	61	Q5JVF3
PGACFNIICNHMRFH	GAL3ST1	131	Q99999
CEGLGRHATFRNFGM	CACNA1G	1776	O43497
ALGHLIGIHFTGCSM	AQP6	181	Q13520
AMAHTHLGGYFFIQC	FSTL4	646	Q6MZW2
LGHCEYAMKAGFHLN	GARRE1	291	O15063
DHAGIFRVFCATMPH	HEPHL1	691	Q6MZM0
GGILDHKMGHLACFS	MAN1C1	441	Q9NR34
GGCMAIHLAYRNHQD	LYPLAL1	126	Q5VWZ2
RNFHHVPFGFGMRQC	CYP11B2	436	P19099
FCGGALIHARFVMTA	AZU1	51	P20160
ISCHDMFDFLHLTGG	PAFAH1B2	186	P68402
SVAMVHGLQHFFSCR	NYNRIN	801	Q9P2P1
HGLQHFFSCRGIAMA	NYNRIN	806	Q9P2P1
HCFTQMFLFHLIGGV	OR4D10	96	Q8NGI6
MHRLQGHFHCVGPAS	RPGRIP1	121	Q96KN7
SLGFEVIAHCGMHYF	TMEM131L	496	A2VDJ0
VFGGRLYCMSDHFHA	TDRD12	761	Q587J7
HGNCVHLGIFFMGIF	PTPN14	226	Q15678
ALGVGLCNNGFMHHV	PREX1	566	Q8TCU6
LFGMVTKFCSGHAPH	STRIP1	266	Q5VSL9
LCADIAMGFRTHHTG	CD84	211	Q9UIB8
AEHHMFCGGSEGSIF	WDR18	226	Q9BV38
CAGFVNHFGRSMSVE	MRE11	146	P49959
GCRFLHGYHRFMHSV	OSM	191	P13725
SSMCGHAVLALGRFA	L3HYPDH	101	Q96EM0
FMGQRVGAISCLAFH	RPTOR	1296	Q8N122
FSYALARGGCMHFHC	RNF31	876	Q96EP0
MQGVGHNFSFVAHLR	TLR9	561	Q9NR96
VEHCGFFRGLFRSGM	KBTBD13	26	C9JR72
LHGICMTFLHNAGKF	STC2	81	O76061
CGMAFGHVSQLTGHQ	ZNF840P	156	A6NDX5
GHGHDAGLRCSEFRM	SCART1	316	Q4G0T1
FGMCFHCLELGVSHN	TTC21A	551	Q8NDW8
HVVSAGGRAEMHCFS	WDR6	801	Q9NNW5
LHFGHPAIMNSCVFG	LGALS14	56	Q8TCE9
HGSMLRAHRCVLAAG	ZBTB20	111	Q9HC78
CGKAFHHLGSFQRHM	ZNF442	326	Q9H7R0
NVNMAAHHGAGAFFR	ZIC1	201	Q15915
EHMASHGTRFLRGCA	TXNRD2	266	Q9NNW7
CGAGVFMASHFDRHY	RPS27A	126	P62979
SQHSCARLEKFMHFG	WDR87	451	Q6ZQQ6
LCGREFAHASGMQYH	ZBTB40	811	Q9NUA8
EQGPLCVHFAHHMFG	ZAN	111	Q9Y493