Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	1.81e-04	679	82	11	3.30.160.60
Domain	zf-C2H2	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	2.16e-04	693	82	11	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	2.19e-04	694	82	11	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	5.58e-04	775	82	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	5.70e-04	777	82	11	PS00028
Domain	Znf_C2H2-like	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	6.96e-04	796	82	11	IPR015880
Domain	Znf_C2H2	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	7.63e-04	805	82	11	IPR007087
Domain	ZnF_C2H2	ZNF594 ZNF550 ZNF628 ZNF337 ZNF644 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF284	7.87e-04	808	82	11	SM00355
Domain	KRAB	ZNF550 ZNF337 ZNF808 ZNF221 ZNF519 ZNF783 ZNF284	9.94e-04	358	82	7	PS50805
Domain	KRAB	ZNF550 ZNF337 ZNF808 ZNF221 ZNF519 ZNF783 ZNF284	9.94e-04	358	82	7	PF01352
Domain	KRAB	ZNF550 ZNF337 ZNF808 ZNF221 ZNF519 ZNF783 ZNF284	1.18e-03	369	82	7	SM00349
Domain	KRAB	ZNF550 ZNF337 ZNF808 ZNF221 ZNF519 ZNF783 ZNF284	1.20e-03	370	82	7	IPR001909
Domain	C1_1	KSR1 ARHGEF28 PRKCH	2.01e-03	57	82	3	PF00130
Domain	ZF_DAG_PE_1	KSR1 ARHGEF28 PRKCH	2.80e-03	64	82	3	PS00479
Domain	ZF_DAG_PE_2	KSR1 ARHGEF28 PRKCH	2.80e-03	64	82	3	PS50081
Domain	C1	KSR1 ARHGEF28 PRKCH	2.93e-03	65	82	3	SM00109
Domain	PE/DAG-bd	KSR1 ARHGEF28 PRKCH	3.06e-03	66	82	3	IPR002219
Domain	Actinin_actin-bd_CS	SPTBN5 ACTN4	4.54e-03	23	82	2	IPR001589
Domain	Spectrin	SPTBN5 ACTN4	4.54e-03	23	82	2	PF00435
Domain	ACTININ_2	SPTBN5 ACTN4	4.54e-03	23	82	2	PS00020
Domain	ACTININ_1	SPTBN5 ACTN4	4.54e-03	23	82	2	PS00019
Domain	Spectrin_repeat	SPTBN5 ACTN4	7.16e-03	29	82	2	IPR002017
Domain	FHA_DOMAIN	PHF12 SLMAP	8.15e-03	31	82	2	PS50006
Domain	Spectrin/alpha-actinin	SPTBN5 ACTN4	8.67e-03	32	82	2	IPR018159
Domain	SPEC	SPTBN5 ACTN4	8.67e-03	32	82	2	SM00150
Pubmed	NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide.	NEK5 TOP2B	6.19e-06	2	87	2	31090963
Pubmed	Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are associated with risk of colorectal cancer.	STIM1 ITPKC	1.85e-05	3	87	2	33470690
Pubmed	Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.	KSR1 DIRAS3	3.70e-05	4	87	2	27368419
Pubmed	The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).	STIM1 KSR1	6.16e-05	5	87	2	24672054
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	ASPA FGF5 CDK5RAP2 ACTN4 TOP2B	7.23e-05	171	87	5	20201926
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	STIM1 SPTBN5 EMC1 ACO2 ZNF644 DHCR7 MRPS24 TMX4 SLMAP CDK5RAP2 PRKCH MRPL3 USP19	8.64e-05	1496	87	13	32877691
Pubmed	Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.	CHST15 NDST2	9.22e-05	6	87	2	19915053
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	STIM1 DMXL2 EMC1 ZNF644 DHCR7 MRPS24 TMX4 SLMAP CDK5RAP2 SMARCAD1 MRPL3 TOP2B	3.26e-04	1487	87	12	33957083
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	CRY2 ZNF337 ACO2 NUP88 TMEM175 ACTN4 SERINC5 HERPUD1	3.63e-04	697	87	8	28298427
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	STIM1 DMXL2 EMC1 ACO2 DHCR7 NUP88 TMX4 TENM1 ACTN4 MRPL3	5.57e-04	1139	87	10	36417873
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CHST15 ZNF644 OGFOD1 SMARCAD1 BCL11A USP19	5.63e-04	407	87	6	12693553
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TRPM6 EMC1 ACO2 DHCR7 GART NUP88 ACTN4 SMARCAD1 MED23 TOP2B USP19	8.48e-04	1425	87	11	30948266
Pubmed	HIV-host interactome revealed directly from infected cells.	STIM1 GART TMX4 TAPBP	9.34e-04	172	87	4	27375898
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	TRPM6 ACO2 GART NUP88 ACTN4 KLB	9.58e-04	451	87	6	36168627
Pubmed	A genome-wide association study of the metabolic syndrome in Indian Asian men.	ZNF644 HERPUD1	1.03e-03	19	87	2	20694148
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF221 ZNF284	1.14e-03	20	87	2	12743021
Pubmed	Meta-analysis identifies four new loci associated with testicular germ cell tumor.	LIPG SMARCAD1	1.14e-03	20	87	2	23666239
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	STIM1 EMC1 DHCR7 TMX4 HERPUD1 USP19	1.16e-03	468	87	6	31056421
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SLMAP OGFOD1 CDK5RAP2	2.11e-03	101	87	3	10997877
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EMC1 PHF12 TMX4 SLMAP CDK5RAP2 MED23	2.15e-03	529	87	6	14621295
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZNF644 BCL11A TOP2B	2.23e-03	103	87	3	32744500
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	DMXL2 ACTN4 MED23	2.23e-03	103	87	3	29539633
Pubmed	FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system.	FGF5 KLB	2.40e-03	29	87	2	21876757
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ITPKC ZNF550 ZNF628 ZNF575 PLEKHA4 PPP1R37 ZNF808 ACTN4 ZNF221 ZNF284	8.79e-05	1192	87	10	chr19q13
Cytoband	19p13.3	MATK CACTIN-AS1 PWWP3A RFX2	1.10e-03	237	87	4	19p13.3
Cytoband	17q11.2	KSR1 PHF12 RSKR	1.23e-03	110	87	3	17q11.2
Cytoband	19q13.31	ZNF575 ZNF284	1.39e-03	29	87	2	19q13.31
Cytoband	Ensembl 112 genes in cytogenetic band chr16q13	OGFOD1 HERPUD1	2.64e-03	40	87	2	chr16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr17q11	KSR1 PHF12 RSKR	4.28e-03	171	87	3	chr17q11
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	ZNF594 ASPA NUP88 RTN4RL1	4.32e-03	346	87	4	chr17p13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF594 ZNF550 ZNF628 ZNF337 ZNF575 ZNF808 ZNF221 BCL11A ZNF519 ZNF783 ZNF284	7.22e-06	718	54	11	28
Coexpression	GSE37301_PRO_BCELL_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_UP	CRY2 ITPKC RTN4RL1 PRKCH SERINC5 TEX13A	8.78e-06	146	86	6	M8904
ToppCell	Sepsis-Int-URO-Others-RBC\|Int-URO / Disease, condition lineage and cell class	ZNF575 PLEKHA4 PPP1R37 BCL11A TMEM86A HERPUD1	2.53e-06	198	87	6	29203aaa5c1844f72289e03f585cd5e7fc498a9a
ToppCell	Sepsis-Int-URO-Others\|Int-URO / Disease, condition lineage and cell class	ZNF575 PLEKHA4 PPP1R37 BCL11A TMEM86A HERPUD1	2.53e-06	198	87	6	67f721ea8e60042317ba12efd584f56b07cfb29d
Disease	vitamin D measurement	LIPG DHCR7 UGT2B10 ZNF808 MED23 HERPUD1	4.28e-04	336	85	6	EFO_0004631
Disease	total lipids in very large HDL measurement	LIPG ANKDD1B HERPUD1	9.26e-04	66	85	3	EFO_0022312
Disease	phospholipids in very large HDL measurement	LIPG ANKDD1B HERPUD1	9.26e-04	66	85	3	EFO_0022298
Disease	preeclampsia, hypertension, pregnancy-induced	FGF5 ACTN4	9.59e-04	16	85	2	EFO_0000668, MONDO_0024664
Disease	response to homoharringtonine, cytotoxicity measurement	METTL3 DMRT3	1.08e-03	17	85	2	EFO_0006952, EFO_0006996
Disease	esterified cholesterol measurement, high density lipoprotein cholesterol measurement	LIPG HERPUD1	1.36e-03	19	85	2	EFO_0004612, EFO_0008589
Disease	level of Phosphatidylcholine (16:0_18:2) in blood serum	LIPG HERPUD1	1.51e-03	20	85	2	OBA_2045071
Disease	free cholesterol in large HDL measurement	LIPG ANKDD1B HERPUD1	1.56e-03	79	85	3	EFO_0022157
Disease	beta-amyloid 1-42 measurement	TRPM6 PPP1R37 DLEC1	2.05e-03	87	85	3	EFO_0004670
Disease	HMG CoA reductase inhibitor use measurement	LIPG UGT2B10 FGF5 HERPUD1	2.20e-03	189	85	4	EFO_0009932
Disease	C-reactive protein measurement	DMXL2 ARHGEF28 LIPG ZNF644 NDST2 PPP1R37 RTN4RL1 KIAA2012 HERPUD1 TOP2B	2.43e-03	1206	85	10	EFO_0004458
Disease	cholesterol to total lipids in small LDL percentage	LIPG HERPUD1	2.75e-03	27	85	2	EFO_0022241

Protein segments in the cluster

Peptide	Gene	Start	Entry
HISAAGPWLKFRGHL	ACO2	596	Q99798
KWGIGYHLSLHLNER	ABCA9	706	Q8IUA7
SWKDGLAFNALIHRH	ACTN4	191	O43707
RWAGHLGSKHFPSQA	CFAP46	2451	Q8IYW2
IHHFSGKLLATGIQW	ANGPTL5	346	Q86XS5
IKVWRLTGHGLIHSF	DMXL2	2966	Q8TDJ6
GSARTAAGKSFHHLW	CACTIN-AS1	176	Q8N1I8
DGQRHHSKLLVSGFW	DHCR7	386	Q9UBM7
HSKLLVSGFWGVARH	DHCR7	391	Q9UBM7
RLVTGHHLWASKNGR	CDK5RAP2	1711	Q96SN8
HHLWASKNGRHVLGL	CDK5RAP2	1716	Q96SN8
SHLFLHGNKLWSLGP	RTN4RL1	176	Q86UN2
DAPLFRNWAIHTGKH	IRF2	51	P14316
SLLFVHDHTGLAKVW	ITPKC	621	Q96DU7
GWSVGHLKAHLSRVY	HERPUD1	31	Q15011
QAHSKLGNRKLLWHG	PARP3	371	Q9Y6F1
SLLGHWKHGRQRSLP	ARHGEF28	1526	Q8N1W1
QGELRHWKTGHYTLI	OGFOD1	436	Q8N543
WYRVKHHTSGQEGLL	MATK	86	P42679
GHTKVLSWLLLHGGE	ESPN	251	B1AK53
HIADKLLHWRGLSSP	BCL11A	126	Q9H165
RLSHPGHFWKSADIN	KSR1	886	Q8IVT5
LGWFVQISLGLKHIH	NEK5	106	Q6P3R8
TVFKSHAWGILHTLL	MED23	591	Q9ULK4
WHHSSIGQLSLIPKF	MED23	1216	Q9ULK4
SRKAFGHGRIDHSWL	KIAA2012	301	Q0VF49
FVHSLGDSWQGKRHL	RSKR	166	Q96LW2
GIFENWLHKLVSALH	LIPG	96	Q9Y5X9
IIRTGRTGHWLNHGK	METTL3	466	Q86U44
HLNISFNKHIGTRGW	PPP1R37	166	O75864
FSHLILSAWAHGEKR	FGF5	11	P12034
SASSVHWFRKGLRLH	CRY2	21	Q49AN0
HWFRKGLRLHDNPAL	CRY2	26	Q49AN0
RCRNHGVLSWLKGHK	DMRT3	31	Q9NQL9
QHLTKSAGLGLKGWH	DUSP16	526	Q9BY84
QVHAHWEKGGLLGRL	DDX11L8	716	A8MPP1
THFRPHQKGWLSITL	KLB	286	Q86Z14
KRNWFLGHLGLIHSS	CYP4F3	56	Q08477
LALHHLSSGHLKWVE	EMC1	151	Q8N766
TLLPTQFHWGKLLGH	DLEC1	996	Q9Y238
STLLHKWASGNFRHE	DIRAS3	51	O95661
LHGLRNLWQILFHIG	SEC22C	266	Q9BRL7
IKWSHLTGIIDIHFG	OTOGL	1656	Q3ZCN5
VGLTWIHKLHKFLGS	NUP88	416	Q99567
RTHIWLFVRGLHGKS	MRPL3	31	P09001
IHHKNWTLASKRGGN	PWWP3A	206	Q2TAK8
YIAHRKGWLSLHTGN	MRPS24	61	Q96EL2
AKGTGSENLHHGILW	SLFN14	686	P0C7P3
KGLLINFIHHNWPSL	TOP2B	571	Q02880
NWLALVHKHGLNGIL	SMARCAD1	506	Q9H4L7
HKSGLLNSHLQWLLD	RFX2	191	P48378
HIRGWLHKQDSSGLR	PLEKHA4	56	Q9H4M7
WEGTALLHHGSYIKL	PHF12	941	Q96QT6
SNLGGWSLNKHHILN	TENM1	1131	Q9UKZ4
ITGYSVLHWLAKHGR	SOWAHD	146	A6NJG2
LLWGLLLHQGQSLSH	STIM1	11	Q13586
WSDGLGFNALIHAHR	SPTBN5	206	Q9NRC6
PASLHRLLNKHVIWG	ACOT4	371	Q8N9L9
DKHGLTVIHLAAWSG	ANKDD1B	131	A6NHY2
HGNELTGVFLVKHWL	ASPA	21	P45381
ALRKAFWGHLAHAHG	CHST15	231	Q7LFX5
SKTGPGEHLRNSLWH	THBS4	841	P35443
AGLFSISGKIWHLHN	TMX4	161	Q9H1E5
WLFLLAHGLGFLLAH	TMEM86A	51	Q8N2M4
AVLLRALWKGTHHAF	USP19	551	O94966
GLLWFAHHSLFLHVR	TMEM175	321	Q9BSA9
GKAFIWGSHLTQHQR	ZNF519	466	Q8TB69
FGLESGHQHLPWTRK	TRPM6	816	Q9BX84
LSRNHALVWFDHKTG	SLMAP	51	Q14BN4
HNLLRLHGFTGHKDW	SPATA20	651	Q8TB22
WRRQHLGKGHLLLAA	TAPBP	206	O15533
KSFGHRSKLAAHLWT	ZNF575	126	Q86XF7
HIHNGFWFFKLLLLG	SERINC5	121	Q86VE9
SYKSSLVWHRRLHGG	ZNF808	661	Q8N4W9
QRVLFGHGLSFWLHK	NDST2	276	P52849
GHGLSFWLHKLIFVD	NDST2	281	P52849
GGREHTLAWKLAQSH	GART	11	P22102
WFDTKIGLSNHVRGH	ZNF644	1046	Q9H582
HGQELWIVKRGLSHA	ZNF550	66	Q7Z398
SFGWASCLLKHQRLH	ZNF221	486	Q9UK13
FGWASCLLKHQRLHS	ZNF221	571	Q9UK13
RWLHGFAKLHKSAAQ	TEX13A	91	Q9BXU3
GAKHLRVAAHNLTWF	UGT2B10	471	P36537
IWRTAFLKHQSLHTG	ZNF594	526	Q96JF6
WASGILRHKRLHTGE	ZNF284	466	Q2VY69
VFNNKHSGLWHSGLI	TOR1B	251	O14657
HSGLWHSGLIDKNLI	TOR1B	256	O14657
GFNWKGNLLTHQRTH	ZNF337	636	Q9Y3M9
LLLHQRLHTGNGQGW	ZNF783	451	Q6ZMS7
HHMFGLSWGAQLRLL	ZAN	121	Q9Y493
CGKSFRWSSRLLHHQ	ZNF628	41	Q5EBL2
RWSLRHSLFKKGHQL	PRKCH	26	P24723
HNDWIIHLAGKLLAS	LMF1	476	Q96S06
SHKGQKLWRSNGSLH	N4BP3	136	O15049