Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HEAT_REPEAT	PPP4R1 SF3B1 MROH2A TOGARAM1 HEATR5A BTAF1 ECPAS NCAPG2	5.44e-10	70	79	8	PS50077
Domain	ARM-like	PPP4R1 SF3B1 AP5Z1 MROH2A NOC4L DAAM2 TOGARAM1 HEATR5A BTAF1 ECPAS NCAPG2	1.78e-08	270	79	11	IPR011989
Domain	HEAT	PPP4R1 SF3B1 TOGARAM1 BTAF1 ECPAS NCAPG2	1.60e-07	58	79	6	IPR000357
Domain	ARM-type_fold	PPP4R1 USP34 SF3B1 MROH2A NOC4L DAAM2 TOGARAM1 HEATR5A BTAF1 ECPAS NCAPG2	1.80e-07	339	79	11	IPR016024
Domain	-	PPP4R1 SF3B1 AP5Z1 DAAM2 TOGARAM1 HEATR5A BTAF1 ECPAS NCAPG2	4.03e-07	222	79	9	1.25.10.10
Domain	HEAT	PPP4R1 SF3B1 BTAF1 ECPAS NCAPG2	1.77e-06	48	79	5	PF02985
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	1.05e-04	4	79	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	1.05e-04	4	79	2	PF08429
Domain	zf-C5HC2	KDM5C KDM5D	1.75e-04	5	79	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	1.75e-04	5	79	2	IPR004198
Domain	JmjN	KDM5C KDM5D	7.78e-04	10	79	2	SM00545
Domain	JMJN	KDM5C KDM5D	7.78e-04	10	79	2	PS51183
Domain	JmjN	KDM5C KDM5D	7.78e-04	10	79	2	PF02375
Domain	JmjN	KDM5C KDM5D	7.78e-04	10	79	2	IPR003349
Domain	-	KDM5C KDM5D	1.79e-03	15	79	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	1.79e-03	15	79	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	1.79e-03	15	79	2	IPR001606
Domain	ARID	KDM5C KDM5D	1.79e-03	15	79	2	PS51011
Domain	ARID	KDM5C KDM5D	1.79e-03	15	79	2	PF01388
Domain	JmjC	KDM5C KDM5D	4.59e-03	24	79	2	PF02373
Domain	JMJC	KDM5C KDM5D	8.07e-03	32	79	2	PS51184
Domain	JmjC_dom	KDM5C KDM5D	8.07e-03	32	79	2	IPR003347
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 DHX36 GGA2 KDM5C AP5Z1 SPIRE1 HIC2 CACNA1G ECPAS DNMBP WDR43 IGSF3	4.93e-09	529	83	12	14621295
Pubmed	STUB1 is essential for T-cell activation by ubiquitinating CARMA1.	MALT1 MAP3K7 CHUK	4.56e-07	7	83	3	23322406
Pubmed	The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.	MALT1 MAP3K7 CHUK	1.09e-06	9	83	3	18625728
Pubmed	Regulation and function of IKK and IKK-related kinases.	MALT1 MAP3K7 CHUK	2.13e-06	11	83	3	17047224
Pubmed	MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation.	MALT1 MAP3K7 CHUK	2.13e-06	11	83	3	25748427
Pubmed	Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.	MALT1 MAP3K7 CHUK	2.84e-06	12	83	3	17363905
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MDN1 PER2 DAAM2 ECPAS PDZD2	5.24e-06	104	83	5	9205841
Pubmed	Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions.	A2M ALK	5.63e-06	2	83	2	28705706
Pubmed	HIPK1 interacts with c-Myb and modulates its activity through phosphorylation.	HIPK1 MYB	5.63e-06	2	83	2	19646965
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	5.63e-06	2	83	2	10441747
Pubmed	Characterization of the aberrant splicing of MAP3K7 induced by cancer-associated SF3B1 mutation.	SF3B1 MAP3K7	5.63e-06	2	83	2	33751071
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	5.63e-06	2	83	2	16416087
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	5.63e-06	2	83	2	32081420
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	5.63e-06	2	83	2	9060413
Pubmed	TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling.	MALT1 MAP3K7	5.63e-06	2	83	2	32388054
Pubmed	Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation.	MAP3K7 CHUK	5.63e-06	2	83	2	26189595
Pubmed	SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes.	SF3B1 MAP3K7	5.63e-06	2	83	2	34930825
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	5.63e-06	2	83	2	7524912
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	1.69e-05	3	83	2	7544442
Pubmed	Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation.	MAP3K7 CHUK	1.69e-05	3	83	2	10187861
Pubmed	UV-sensitive photoreceptor protein OPN5 in humans and mice.	PER2 OPN5	1.69e-05	3	83	2	22043319
Pubmed	PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.	PRKAR2A PTGDR	1.69e-05	3	83	2	27621415
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	3.37e-05	4	83	2	16541399
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	3.37e-05	4	83	2	17320160
Pubmed	Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.	MAP3K7 MYB	3.37e-05	4	83	2	15082531
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	3.37e-05	4	83	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	3.37e-05	4	83	2	7951230
Pubmed	Molecular determinants of NF-kappaB-inducing kinase action.	MAP3K7 CHUK	3.37e-05	4	83	2	9742107
Pubmed	T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome.	MALT1 CHUK	3.37e-05	4	83	2	24825920
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP34 GLMN PIGT SF3B1 MDN1 PEX19 ASCC2 NOC4L BTAF1 ECPAS NCAPG2 SAMD4A CHUK	3.54e-05	1440	83	13	30833792
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 PER2 HIPK1 DAAM2 HEATR5A TENM2 PDZD2	5.52e-05	407	83	7	12693553
Pubmed	TRIM56 positively regulates TNFα-induced NF-κB signaling by enhancing the ubiquitination of TAK1.	MAP3K7 CHUK	5.60e-05	5	83	2	35952808
Pubmed	Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes.	MAP3K7 CHUK	5.60e-05	5	83	2	20200282
Pubmed	Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.	MAP3K7 CHUK	5.60e-05	5	83	2	17379600
Pubmed	Loss of Function Genetic Screen Identifies ATM Kinase as a Positive Regulator of TLR3-Mediated NF-κB Activation.	MAP3K7 CHUK	5.60e-05	5	83	2	32731169
Pubmed	The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection.	MAP3K7 CHUK	5.60e-05	5	83	2	37100289
Pubmed	IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.	IRF5 CHUK	5.60e-05	5	83	2	19786094
Pubmed	Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.	MAP3K7 CHUK	5.60e-05	5	83	2	10195894
Pubmed	p63 induces key target genes required for epidermal morphogenesis.	FRAS1 CHUK	5.60e-05	5	83	2	17360634
Pubmed	Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway.	MAP3K7 CHUK	5.60e-05	5	83	2	19774455
Pubmed	Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin.	PER2 OPN5	5.60e-05	5	83	2	31607531
Pubmed	IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.	MAP3K7 CHUK	5.60e-05	5	83	2	10779355
Pubmed	Hepatitis B e Antigen Inhibits NF-κB Activity by Interrupting K63-Linked Ubiquitination of NEMO.	MAP3K7 CHUK	5.60e-05	5	83	2	30404796
Pubmed	TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.	MAP3K7 CHUK	5.60e-05	5	83	2	12547194
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	GLMN PIGT CEP120 AP5Z1 ASCC2 ECPAS ANAPC5 CLUH	5.88e-05	560	83	8	35241646
Pubmed	Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IκB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a β-arrestin/TRAF6 complex.	MAP3K7 CHUK	8.39e-05	6	83	2	23960234
Pubmed	IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).	MAP3K7 CHUK	8.39e-05	6	83	2	26334375
Pubmed	Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.	PER2 OPN5	8.39e-05	6	83	2	32543667
Pubmed	ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.	MAP3K7 CHUK	8.39e-05	6	83	2	34490261
Pubmed	The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1.	MAP3K7 CHUK	8.39e-05	6	83	2	16280329
Pubmed	Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.	MAP3K7 CHUK	8.39e-05	6	83	2	11585904
Pubmed	USP2a positively regulates TCR-induced NF-κB activation by bridging MALT1-TRAF6.	MALT1 MAP3K7	8.39e-05	6	83	2	23264041
Pubmed	Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.	MAP3K7 CHUK	8.39e-05	6	83	2	11809792
Pubmed	Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.	MAP3K7 CHUK	8.39e-05	6	83	2	16893890
Pubmed	Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.	MAP3K7 CHUK	1.17e-04	7	83	2	12842894
Pubmed	IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway.	MAP3K7 CHUK	1.17e-04	7	83	2	23778976
Pubmed	The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.	MALT1 MAP3K7	1.17e-04	7	83	2	21896478
Pubmed	Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.	MAP3K7 CHUK	1.17e-04	7	83	2	9744859
Pubmed	A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells.	PRKAR2A DNMBP NCAPG2	1.21e-04	40	83	3	17540781
Pubmed	USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.	MAP3K7 CHUK	1.56e-04	8	83	2	26240016
Pubmed	I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.	MAP3K7 CHUK	1.56e-04	8	83	2	23422957
Pubmed	CHIP promotes the activation of NF-κB signaling through enhancing the K63-linked ubiquitination of TAK1.	MAP3K7 CHUK	1.56e-04	8	83	2	34535633
Pubmed	Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK.	MAP3K7 CHUK	1.56e-04	8	83	2	17363973
Pubmed	Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.	MAP3K7 CHUK	1.56e-04	8	83	2	15590691
Pubmed	Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.	MALT1 MAP3K7	1.56e-04	8	83	2	17948050
Pubmed	The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.	MALT1 MAP3K7	1.56e-04	8	83	2	17189706
Pubmed	CEP295 interacts with microtubules and is required for centriole elongation.	CEP120 CEP295	1.56e-04	8	83	2	27185865
Pubmed	MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.	MAP3K7 CHUK	1.56e-04	8	83	2	9689078
Pubmed	The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.	MAP3K7 CHUK	1.56e-04	8	83	2	10094049
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 DHX36 SF3B1 MDN1 NOC4L ECPAS CLUH WDR43	1.69e-04	653	83	8	22586326
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PPP4R1 MALT1 GGA2 PEX19 PRKAR2A MAP3K7 ANAPC5 WDR43 SAMD4A CHUK	1.82e-04	1038	83	10	26673895
Pubmed	Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.	MALT1 CHUK	2.00e-04	9	83	2	14695475
Pubmed	The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4.	MALT1 MAP3K7	2.00e-04	9	83	2	16831874
Pubmed	Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation.	MAP3K7 CHUK	2.00e-04	9	83	2	18949366
Pubmed	Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea.	PER2 OPN5	2.00e-04	9	83	2	26392540
Pubmed	Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.	MALT1 TRPV1	2.00e-04	9	83	2	28658621
Pubmed	Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.	MAP3K7 CHUK	2.00e-04	9	83	2	17384642
Pubmed	A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase.	MAP3K7 CHUK	2.00e-04	9	83	2	12624112
Pubmed	Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.	MAP3K7 CHUK	2.00e-04	9	83	2	27387502
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SF3B1 MDN1 HIPK1 KDM5C AP5Z1 HIC2 BTAF1 ECPAS CHUK	2.07e-04	857	83	9	25609649
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 WDR35 TOGARAM1 HIC2 CACNA1G	2.09e-04	225	83	5	12168954
Pubmed	NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein.	MAP3K7 CHUK	2.50e-04	10	83	2	20164171
Pubmed	A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.	MAP3K7 CHUK	2.50e-04	10	83	2	18079694
Pubmed	Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes.	REC8 NCAPG2	2.50e-04	10	83	2	21795393
Pubmed	TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.	MAP3K7 CHUK	2.50e-04	10	83	2	15670770
Pubmed	Gut microbiome and anticancer immune response: really hot Sh*t!	MAP3K7 CHUK	2.50e-04	10	83	2	24832470
Pubmed	Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.	UBE2S UBE2Q2	2.50e-04	10	83	2	33607208
Pubmed	ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.	MAP3K7 CHUK	2.50e-04	10	83	2	20932476
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 FRAS1 MDN1 PER2 TMEM268 SPIRE1 IRF5 BTAF1 DNMBP IGSF3	3.00e-04	1105	83	10	35748872
Pubmed	USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO.	MAP3K7 CHUK	3.05e-04	11	83	2	24270572
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	REC8 PPP4R1 DHX36 BRF1 KIF2B KDM5C NOC4L HIC2 INO80D NCAPG2 WDR43	3.12e-04	1327	83	11	32694731
Pubmed	TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.	MAP3K7 CHUK	3.66e-04	12	83	2	16260493
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	4.31e-04	13	83	2	14660691
Pubmed	Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.	MAP3K7 CHUK	4.31e-04	13	83	2	25523394
Pubmed	The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.	MALT1 TRPV1	4.31e-04	13	83	2	30240621
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5C KDM5D	4.31e-04	13	83	2	24619213
Pubmed	SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.	PER2 FBXL15	5.03e-04	14	83	2	17463251
Pubmed	Activation of IkappaB kinase beta by protein kinase C isoforms.	MAP3K7 CHUK	5.03e-04	14	83	2	10022904
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SF3B1 MDN1 KDM5C BTAF1 ECPAS DNMBP ANAPC5 CLUH	5.27e-04	774	83	8	15302935
Pubmed	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.	MAP3K7 CHUK	5.79e-04	15	83	2	23986494
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	6.51e-04	15	46	2	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	1.69e-03	24	46	2	485
Coexpression	CUI_TCF21_TARGETS_2_DN	MALT1 PER2 SPIRE1 DAAM2 HEATR5A BTAF1 ECPAS ADGRE2 INO80D TENM2 UBE2Q2 SLC27A3 DMXL1 SAMD4A	6.13e-07	888	82	14	MM1018
Coexpression	CUI_TCF21_TARGETS_2_DN	MALT1 PER2 SPIRE1 DAAM2 HEATR5A BTAF1 ECPAS INO80D TENM2 UBE2Q2 SLC27A3 DMXL1 SAMD4A	2.38e-06	854	82	13	M1533
Drug	C5H9O4P	PAPPA KDM5D MYB	1.50e-06	7	81	3	CID004628690
Drug	Cefmetazole sodium salt [56796-39-5]; Up 200; 8.2uM; PC3; HT_HG-U133A	MYBPH GGA2 PER2 KDM5C HIC2 ADGRE2 PTGDR	6.83e-06	198	81	7	5868_UP
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; PC3; HT_HG-U133A	TRPV1 GGA2 KDM5C AP5Z1 IRF5 DNMBP	5.85e-05	189	81	6	1832_DN
Drug	Solasodine [126-17-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	USP34 GGA2 ACTL8 PEX19 ANAPC5 INO80D	6.39e-05	192	81	6	6025_DN
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; MCF7; HT_HG-U133A	GGA2 SF3B1 TBC1D22A HIPK1 AP5Z1 IRF5	6.57e-05	193	81	6	3906_DN
Drug	Tolfenamic acid [13710-19-5]; Down 200; 15.2uM; MCF7; HT_HG-U133A	A2M TRPV1 PEX19 PRKAR2A IRF5 DNMBP	6.76e-05	194	81	6	5454_DN
Drug	Epivincamine [6835-99-0]; Down 200; 11.2uM; HL60; HG-U133A	GLMN MALT1 HIPK1 MAP3K7 ANAPC5 NCAPG2	6.96e-05	195	81	6	1783_DN
Drug	Propoxycaine hydrochloride [550-83-4]; Down 200; 12uM; MCF7; HT_HG-U133A	GGA2 ACTL8 TBC1D22A PRKAR2A FBXL15 SAMD4A	6.96e-05	195	81	6	3583_DN
Drug	Quinic acid [86-68-0]; Up 200; 19.6uM; MCF7; HT_HG-U133A	A2M MALT1 BRF1 ACTL8 AP5Z1 OCA2	7.36e-05	197	81	6	3540_UP
Drug	Idazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; PC3; HT_HG-U133A	GGA2 BRF1 TBC1D22A INO80D ALK SAMD4A	7.36e-05	197	81	6	6747_UP
Drug	Pheniramine maleate [132-20-7]; Up 200; 11.2uM; MCF7; HT_HG-U133A	REC8 GGA2 BRF1 TBC1D22A CACNA1G SAMD4A	7.36e-05	197	81	6	4130_UP
Drug	Trolox [53188-07-1]; Down 200; 16uM; PC3; HT_HG-U133A	GGA2 KDM5C AP5Z1 S100A14 FBXL15 DNMBP	7.57e-05	198	81	6	7304_DN
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A	MALT1 GGA2 PRKAR2A ECPAS PTGDR PDZD2	7.57e-05	198	81	6	5477_UP
Drug	Scoulerine [6451-73-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	AP5Z1 IRF5 DNMBP INO80D SAMD4A PDZD2	7.57e-05	198	81	6	2891_UP
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; HL60; HG-U133A	TRPV1 GGA2 TBC1D22A AP5Z1 PRKAR2A INO80D	7.57e-05	198	81	6	2032_UP
Drug	Nomegestrol acetate [58652-20-3]; Down 200; 10.8uM; PC3; HT_HG-U133A	GGA2 TBC1D22A KDM5C PEX19 IRF5 ECPAS	7.57e-05	198	81	6	6362_DN
Drug	Prostaglandin E1; Down 200; 10uM; MCF7; HT_HG-U133A	A2M TRPV1 TBC1D22A FBXL15 IRF5 SAMD4A	7.57e-05	198	81	6	6576_DN
Drug	Mefexamide hydrochloride [3413-64-7]; Up 200; 12.6uM; MCF7; HT_HG-U133A	ACTL8 TBC1D22A HIC2 IRF5 CACNA1G MYB	7.57e-05	198	81	6	2284_UP
Drug	Carbachol [51-83-2]; Up 200; 21.8uM; PC3; HT_HG-U133A	PER2 TBC1D22A PRKAR2A HIC2 ALK SAMD4A	7.57e-05	198	81	6	6742_UP
Drug	Methimazole [60-56-0]; Up 200; 35uM; MCF7; HT_HG-U133A	REC8 TRPV1 MXRA5 ECPAS INO80D SAMD4A	7.57e-05	198	81	6	3898_UP
Drug	Tetrahydrozoline hydrochloride [522-48-5]; Up 200; 16.8uM; MCF7; HT_HG-U133A	TBC1D22A IRF5 OCA2 INO80D ALK SAMD4A	7.78e-05	199	81	6	6069_UP
Drug	Iobenguane sulfate; Up 200; 10.8uM; HL60; HG-U133A	REC8 TRPV1 GGA2 NOC4L ADGRE2 CLUH	7.78e-05	199	81	6	1729_UP
Drug	Trifluridine [70-00-8]; Up 200; 13.6uM; HL60; HT_HG-U133A	TRPV1 BRF1 PAPPA IRF5 CACNA1G MYB	7.78e-05	199	81	6	6136_UP
Drug	Alprenolol hydrochloride [13707-88-5]; Up 200; 14uM; PC3; HT_HG-U133A	USP34 TRPV1 GGA2 KDM5C SLC27A3 IGSF3	7.78e-05	199	81	6	7141_UP
Drug	Acetazolamide [59-66-5]; Down 200; 18uM; PC3; HT_HG-U133A	GGA2 BRF1 KDM5C AP5Z1 DNMBP SAMD4A	7.78e-05	199	81	6	1808_DN
Drug	felodipine; Down 200; 10uM; MCF7; HG-U133A	A2M USP34 GLMN MXRA5 BRF1 KDM5D	7.78e-05	199	81	6	337_DN
Drug	dimedone	MYBPH OCA2 KDM5D	8.32e-05	24	81	3	CID000031358
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	4.45e-05	4	81	2	DOID:0060809 (implicated_via_orthology)
Disease	cortical thickness	A2M SF3B1 CEP120 TBC1D22A SPATA16 PRKAR2A DNAAF9 MAP3K7 TENM2 CLUH PDZD2	2.26e-04	1113	81	11	EFO_0004840
Disease	Short Rib-Polydactyly Syndrome	CEP120 WDR35	5.69e-04	13	81	2	C0036996
Disease	Saldino-Noonan Syndrome	CEP120 WDR35	6.63e-04	14	81	2	C0036069
Disease	Majewski Syndrome	CEP120 WDR35	6.63e-04	14	81	2	C0024507
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	8.71e-04	16	81	2	DOID:0050888 (implicated_via_orthology)
Disease	serum gamma-glutamyl transferase measurement	CEP120 IQCH FAM227A BCAT2 RP1 DNMBP ANAPC5 TENM2 PIWIL3	8.96e-04	914	81	9	EFO_0004532
Disease	cortical surface area measurement	USP34 SF3B1 CEP120 TBC1D22A SPATA16 PRKAR2A PAPPA DNAAF9 MAP3K7 TENM2 PDZD2	1.10e-03	1345	81	11	EFO_0010736
Disease	maximal midexpiratory flow rate	OCA2 SAMD4A	1.37e-03	20	81	2	EFO_0004313
Disease	eotaxin measurement	TBC1D22A OCA2 PDZD2	1.41e-03	80	81	3	EFO_0008122
Disease	disease	SPATA16 BCAT2	1.51e-03	21	81	2	EFO_0000408
Disease	Glioma	ALK DMXL1 MYB	1.79e-03	87	81	3	C0017638

Protein segments in the cluster

Peptide	Gene	Start	Entry
NLTTLPMIPVDEHLA	FAM227A	11	F5H4B4
EAPLVLEPEKQMLLH	ADGRE2	416	Q9UHX3
LLHVPSVLLADQLQM	ACTL8	121	Q9H568
MPALPLDQLQITHKD	ASCC2	1	Q9H1I8
LLLMELLNSTPESHP	DNMBP	931	Q6XZF7
ERLAPLHQLLQPMAG	AP5Z1	531	O43299
LQQMPLHDTEIPDLV	CC2D2B	746	Q6DHV5
TLPQYHPLQLLELMD	DMXL1	1321	Q9Y485
MDENFHPLNELIPLV	A2M	151	P01023
ETELPSLLLPNHLAM	REC8	111	O95072
ATMIPVLLNLSHDPE	OCA2	746	Q04671
QPLEELDHLLLLALM	PTGDR	256	Q13258
LEDPAHVQMLINLPG	IQCH	346	Q86VS3
IPEQALSLLHMAIEP	ANAPC5	636	Q9UJX4
ILNMPSELQHLPEAA	DAAM2	856	Q86T65
QLLPELEEMILHRNP	KIAA0100	791	Q14667
MILDIVNNLLLHVEP	KIAA0100	1771	Q14667
LQVLDLHNNSLMELP	LRRC55	91	Q6ZSA7
KNPQEMLHLHPLDLQ	MDN1	4151	Q9NU22
MVLTIHLLPSDQQLP	FRAS1	1581	Q86XX4
QAMEHTEVLQLLSPP	MALT1	111	Q9UDY8
VQIIEEHPPLMLQNR	HIPK1	136	Q86Z02
EELNILIHDVPLLAM	CHUK	81	O15111
PDLLHQLVTLMNPNT	KDM5D	551	Q9BY66
QPQQDSLMHLLIPTL	ECPAS	131	Q5VYK3
VLVQLHPSDRPLMLA	PER2	366	O15055
MPITQDNAVLHLPLL	PDZD2	1	O15018
PALQDMHAEIAQPLL	ENPP5	461	Q9UJA9
IPMAYLTLDHQLQPL	MAP3K7	496	O43318
MALNHTALPQDERLP	OPN5	1	Q6U736
PVMVQHIQPAALSLL	HEXD	406	Q8WVB3
VQLPMETLQELLDLH	GBP5	341	Q96PP8
ISQMLLLDNPHKEPI	GGA2	566	Q9UJY4
MLPQTPSHLVEDLQD	MYB	486	P10242
GEQLLPDLLISPHML	IRF5	231	Q13568
DPPLQMDVASILHLN	PAPPA	891	Q13219
VLDLMQQLQDLGHPP	PEX19	251	P40855
MPQTLHRVEQDPLEL	IGSF3	151	O75054
HVEPTLSLIIMLLLN	HEATR5A	971	Q86XA9
LSLIIMLLLNVPPTH	HEATR5A	976	Q86XA9
QPSHLPIDLNMLLEV	BTAF1	616	O14981
TLLLSALESNMQPHP	CACNA1G	2011	O43497
TMPHQLQDTFLRIPL	CEP120	516	Q8N960
PPSNEAVLLSIRHLM	DHX36	661	Q9H2U1
PVMRTHLPVLLQQAE	DNAAF9	721	Q5TEA3
IMAQHLLPTQLEVPL	INO80D	866	Q53TQ3
MSHIQIPPGLTELLQ	PRKAR2A	1	P13861
NLHIPTMENGPELIL	BCAT2	356	O15382
ISQMHDRPLLPSENI	CEP295	826	Q9C0D2
QREPILLIPQLCHMT	PIWIL3	391	Q7Z3Z3
VHDAILPQLAQPTLM	NOC4L	276	Q9BVI4
MTFPHLLNLSEDPQL	KIF28P	381	B7ZC32
QHMSLQIAADSPLLP	CPHXL	371	A0A1W2PPM1
ILLLNPALDSAEHPM	KIF2B	76	Q8N4N8
EETPKDLLPVLMLHQ	RP1	1076	P56715
DLLPVLMLHQLQASV	RP1	1081	P56715
SLLRQPLPMESHLAE	MROH2A	1161	A6NES4
QGIHIDQLPMVLSPL	GLMN	296	Q92990
PDMELPSHSKQLLLQ	HIC2	21	Q96JB3
LMPHLLTLANDRVPN	PPP4R1	866	Q8TF05
EPPLHQALVLLQDMA	FBXL15	276	Q9H469
PRHLLMPDNQIITLT	TENM2	1646	Q9NT68
TELDNQLITMPLPHI	SPATA16	101	Q9BXB7
PAMLDQPIHIRENIE	MYBPH	156	Q13203
LPHNEAAREILLMPT	ALK	366	Q9UM73
MILDNKLSHPLLEQL	NCAPG2	446	Q86XI2
PEMALLDNNIGLVLH	CLUH	1101	O75153
RPLMQTELHQLVPEA	TMEM268	266	Q5VZI3
NLPKHLDVEMLDQPL	UBE2Q2	111	Q8WVN8
DRLQPHLLEMLIQLP	PIGT	421	Q969N2
ETPNRHDMLLVEPLN	TRPV1	406	Q8NER1
ALVLRPPHALDLMQL	SLC27A3	591	Q5K4L6
LPLLMSPTLEDQERH	SF3B1	536	O75533
ERELSPPLEQLIDHM	SPIRE1	146	Q08AE8
LRDLVTQQLPHLMPS	S100A14	46	Q9HCY8
LSLVLQHLEPDMVLP	TMEM86B	136	Q8N661
HIDIPRMSPEALILQ	TBC1D22A	281	Q8WUA7
PHMLLDLSDLLQVNV	BRF1	146	Q92994
MNSNVENLPPHIIRL	UBE2S	1	Q16763
ESVLLHMPQPLNLEL	TRIM49D1	256	C9J1S8
KDNIPMLLLLQEPHL	USP34	1336	Q70CQ2
LRDHLSPIINMLIPA	TOGARAM1	1561	Q9Y4F4
SLPENHKLLPEIAQM	WDR35	851	Q9P2L0
RIPLQELHQMILTPI	SAMD4A	401	Q9UPU9
RMPLHTIIPLLQELT	WDR43	496	Q15061
PDLLHQLVTLMNPNT	KDM5C	561	P41229
LELLMIHGNEIPSIP	MXRA5	81	Q9NR99