Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionMAP kinase tyrosine phosphatase activity

DUSP4 DUSP6 DUSP8 DUSP10

2.89e-07101244GO:0033550
GeneOntologyMolecularFunctionprotein tyrosine/threonine phosphatase activity

DUSP4 DUSP6 DUSP8 DUSP10

4.52e-07111244GO:0008330
GeneOntologyMolecularFunctionMAP kinase tyrosine/serine/threonine phosphatase activity

DUSP4 DUSP6 DUSP8 DUSP10

9.70e-07131244GO:0017017
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NPC1 LILRA1 DRD5 OR5V1 OR10H4 CR1L OR4M2B OR10G6 MET CELSR1 OR4S1 OR6B3 CELSR3 OR10G3 OR10G2 IL1R2 OR10W1 PKD1 KIR3DL3 OR10K2 OR4C12 GRIN3A OR6T1 PLXNA2

2.61e-06135312424GO:0004888
GeneOntologyMolecularFunctionMAP kinase phosphatase activity

DUSP4 DUSP6 DUSP8 DUSP10

4.05e-06181244GO:0033549
GeneOntologyMolecularFunctionprotein tyrosine/serine/threonine phosphatase activity

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

6.79e-06431245GO:0008138
GeneOntologyMolecularFunctionolfactory receptor activity

OR5V1 OR10H4 OR4M2B OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

1.58e-0543112412GO:0004984
GeneOntologyMolecularFunctionprotein tyrosine phosphatase activity

DUSP4 DUSP6 DUSP8 TNS2 DUSP15 DUSP10

4.44e-051031246GO:0004725
GeneOntologyMolecularFunctionmyosin phosphatase activity

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

1.88e-04851245GO:0017018
GeneOntologyMolecularFunctionglucokinase activity

HK1 HKDC1

3.78e-0451242GO:0004340
GeneOntologyMolecularFunctionhexokinase activity

HK1 HKDC1

3.78e-0451242GO:0004396
GeneOntologyMolecularFunctionfructokinase activity

HK1 HKDC1

3.78e-0451242GO:0008865
GeneOntologyMolecularFunctionG protein-coupled receptor activity

DRD5 OR5V1 OR10H4 OR4M2B OR10G6 CELSR1 OR4S1 OR6B3 CELSR3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

3.87e-0488412415GO:0004930
GeneOntologyMolecularFunctionphosphatase activity

DUSP4 DUSP6 DUSP8 TNS2 DUSP15 PLPPR4 DUSP10 G6PC2

4.31e-042871248GO:0016791
GeneOntologyMolecularFunctionprotein serine/threonine phosphatase activity

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

5.94e-041091245GO:0004722
GeneOntologyMolecularFunction3-keto sterol reductase activity

DHRS11 HSD3B2

1.05e-0381242GO:0000253
GeneOntologyMolecularFunctionphosphoprotein phosphatase activity

DUSP4 DUSP6 DUSP8 TNS2 DUSP15 DUSP10

1.18e-031891246GO:0004721
GeneOntologyBiologicalProcesspeptidyl-tyrosine dephosphorylation

DUSP4 DUSP6 DUSP8 TNS2 DUSP10

1.82e-06341255GO:0035335
GeneOntologyBiologicalProcesssensory perception of smell

OR5V1 UGT2A2 OR10H4 OR4M2B OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

5.08e-0646512513GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5V1 OR10H4 OR4M2B OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

1.28e-0543212512GO:0050911
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5V1 UGT2A2 OR10H4 OR4M2B OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

2.84e-0554712513GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5V1 OR10H4 OR4M2B OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

3.97e-0548512512GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5V1 OR10H4 OR4M2B OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

8.32e-0552412512GO:0009593
GeneOntologyBiologicalProcesssmoothened signaling pathway

HSPG2 MKS1 CC2D2A DISP2 SUFU HERC4 CDON

1.00e-041761257GO:0007224
GeneOntologyBiologicalProcessdetection of stimulus

OR5V1 OR10H4 PKDREJ OR4M2B OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 PKD1 OR10K2 OR4C12 OR6T1

1.24e-0472212514GO:0051606
MousePhenoenlarged pancreas

CTRB2 SIRT1 PKD1 CTRB1

2.18e-0525944MP:0003450
MousePhenoexocrine pancreas atrophy

SIRT1 PKD1

4.47e-052942MP:0009164
MousePhenoabnormal muscle relaxation

DUSP8 CLCN1 PIK3CG KCNMA1 ATP2A3

5.46e-0561945MP:0004036
DomainMKP

DUSP4 DUSP6 DUSP8 DUSP10

3.42e-07101214IPR008343
DomainDUSP

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

1.56e-06311215IPR024950
DomainTYR_PHOSPHATASE_DUAL

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

2.51e-06341215PS50054
DomainDSPc

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

2.92e-06351215SM00195
DomainTYR_PHOSPHATASE_DUAL_dom

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

2.92e-06351215IPR020422
DomainDual-sp_phosphatase_cat-dom

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

6.53e-06411215IPR000340
DomainDSPc

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

6.53e-06411215PF00782
DomainRHOD

DUSP4 DUSP6 DUSP8 DUSP10

1.12e-05221214SM00450
DomainRHODANESE_3

DUSP4 DUSP6 DUSP8 DUSP10

1.35e-05231214PS50206
DomainRhodanese-like_dom

DUSP4 DUSP6 DUSP8 DUSP10

1.61e-05241214IPR001763
DomainRhodanese

DUSP4 DUSP6 DUSP8 DUSP10

1.61e-05241214PF00581
Domain-

DUSP4 DUSP6 DUSP8 DUSP10

1.61e-052412143.40.250.10
Domain-

DUSP4 DUSP6 DUSP8 TNS2 DUSP15 DUSP10

2.95e-059212163.90.190.10
DomainRibosomal_S27e

RPS27 RPS27L

4.16e-0521212IPR000592
DomainRibosomal_S27e_Zn-bd_dom

RPS27 RPS27L

4.16e-0521212IPR023407
DomainRibosomal_S27e

RPS27 RPS27L

4.16e-0521212PD004466
DomainRIBOSOMAL_S27E

RPS27 RPS27L

4.16e-0521212PS01168
DomainRibosomal_S27e

RPS27 RPS27L

4.16e-0521212PF01667
Domain-

RPS27 RPS27L

4.16e-05212122.20.25.100
DomainProt-tyrosine_phosphatase-like

DUSP4 DUSP6 DUSP8 TNS2 DUSP15 DUSP10

4.48e-05991216IPR029021
DomainOlfact_rcpt

OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

5.01e-0539312111IPR000725
DomainGPS

PKDREJ CELSR1 CELSR3 PKD1

6.69e-05341214SM00303
DomainSSD

NPC1 SCAP DISP2

7.23e-05131213IPR000731
DomainSSD

NPC1 SCAP DISP2

7.23e-05131213PS50156
DomainGPS

PKDREJ CELSR1 CELSR3 PKD1

9.38e-05371214IPR000203
DomainLAM_G_DOMAIN

HSPG2 FAT1 CELSR1 CELSR3

1.04e-04381214PS50025
DomainLaminin_G_2

HSPG2 FAT1 CELSR1 CELSR3

1.28e-04401214PF02210
DomainIGc2

HSPG2 LILRA1 IGDCC3 IGSF10 NEO1 IL1R2 LRFN5 CDON

1.48e-042351218SM00408
DomainIg_sub2

HSPG2 LILRA1 IGDCC3 IGSF10 NEO1 IL1R2 LRFN5 CDON

1.48e-042351218IPR003598
DomainLamG

HSPG2 FAT1 CELSR1 CELSR3

1.86e-04441214SM00282
DomainTYR_PHOSPHATASE_1

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

2.41e-04861215PS00383
DomainREJ

PKDREJ PKD1

2.48e-0441212PS51111
DomainREJ_dom

PKDREJ PKD1

2.48e-0441212IPR014010
DomainTYR_PHOSPHATASE_dom

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

2.54e-04871215IPR000387
DomainTYR_PHOSPHATASE_2

DUSP4 DUSP6 DUSP8 DUSP15 DUSP10

2.54e-04871215PS50056
Domain-

POC1A EDC4 LYST MET SCAP WDR6 TLE6 GNB2 PLXNA2

3.21e-0433312192.130.10.10
DomainWD40/YVTN_repeat-like_dom

POC1A EDC4 LYST MET SCAP WDR6 TLE6 GNB2 PLXNA2

3.35e-043351219IPR015943
DomainHexokinase_2

HK1 HKDC1

4.11e-0451212PF03727
DomainSterol-sensing

NPC1 SCAP

4.11e-0451212PF12349
DomainHexokinase_BS

HK1 HKDC1

4.11e-0451212IPR019807
DomainHexokinase_C

HK1 HKDC1

4.11e-0451212IPR022673
DomainHexokinase_N

HK1 HKDC1

4.11e-0451212IPR022672
DomainHexokinase_1

HK1 HKDC1

4.11e-0451212PF00349
DomainHEXOKINASE_2

HK1 HKDC1

4.11e-0451212PS51748
DomainHEXOKINASE_1

HK1 HKDC1

4.11e-0451212PS00378
DomainLaminin_G

HSPG2 FAT1 CELSR1 CELSR3

5.43e-04581214IPR001791
DomainHexokinase

HK1 HKDC1

6.14e-0461212IPR001312
DomainPKD/REJ-like

PKDREJ PKD1

6.14e-0461212IPR002859
DomainREJ

PKDREJ PKD1

6.14e-0461212PF02010
Domain-

DHRS11 DHDH KCNMA1 HSD3B2 FAR1 PYCR2

8.18e-0416912163.40.50.720
DomainNAD(P)-bd_dom

DHRS11 DHDH KCNMA1 HSD3B2 FAR1 PYCR2

9.24e-041731216IPR016040
DomainEGF_LAM_2

HSPG2 CELSR1 CELSR3

9.48e-04301213PS50027
DomainEGF_LAM_1

HSPG2 CELSR1 CELSR3

9.48e-04301213PS01248
DomainEGF_CA

HSPG2 FAT1 CELSR1 CELSR3 FBN3

1.19e-031221215SM00179
DomainEGF-like_Ca-bd_dom

HSPG2 FAT1 CELSR1 CELSR3 FBN3

1.28e-031241215IPR001881
DomainTyr_Pase_AS

DUSP4 DUSP8 DUSP15 DUSP10

1.29e-03731214IPR016130
DomainEGF

HSPG2 FAT1 CELSR1 CELSR3 FBN3

1.37e-031261215PF00008
DomainRibosomal_zn-bd

RPS27 RPS27L

1.45e-0391212IPR011332
Domain7tm_1

DRD5 OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

1.49e-0367712112PF00001
DomainEGF_Lam

HSPG2 CELSR1 CELSR3

1.49e-03351213SM00180
DomainGPS

CELSR1 CELSR3 PKD1

1.49e-03351213PF01825
DomainLaminin_EGF

HSPG2 CELSR1 CELSR3

1.49e-03351213PF00053
DomainIg_I-set

HSPG2 IGDCC3 IGSF10 NEO1 LRFN5 CDON

1.50e-031901216IPR013098
DomainI-set

HSPG2 IGDCC3 IGSF10 NEO1 LRFN5 CDON

1.50e-031901216PF07679
Domainig

HSPG2 LILRA1 IGDCC3 IL1R2 KIR3DL3 CDON

1.50e-031901216PF00047
DomainImmunoglobulin

HSPG2 LILRA1 IGDCC3 IL1R2 KIR3DL3 CDON

1.50e-031901216IPR013151
DomainGPS

CELSR1 CELSR3 PKD1

1.62e-03361213PS50221
DomainG_PROTEIN_RECEP_F1_1

DRD5 OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

1.64e-0368512112PS00237
DomainIG

HSPG2 LILRA1 IGDCC3 IGSF10 NEO1 IL1R2 LRFN5 KIR3DL3 CDON

1.69e-034211219SM00409
DomainIg_sub

HSPG2 LILRA1 IGDCC3 IGSF10 NEO1 IL1R2 LRFN5 KIR3DL3 CDON

1.69e-034211219IPR003599
DomainG_PROTEIN_RECEP_F1_2

DRD5 OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

1.76e-0369112112PS50262
DomainGPCR_Rhodpsn

DRD5 OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

1.79e-0369212112IPR000276
DomainWD40

POC1A EDC4 LYST SCAP WDR6 TLE6 GNB2

1.82e-032681217SM00320
DomainLaminin_EGF

HSPG2 CELSR1 CELSR3

1.90e-03381213IPR002049
DomainWD40_repeat

POC1A EDC4 LYST SCAP WDR6 TLE6 GNB2

1.98e-032721217IPR001680
DomainGAIN_dom_N

CELSR1 CELSR3

2.20e-03111212IPR032471
DomainPKD_channel

PKDREJ PKD1

2.20e-03111212PF08016
DomainGAIN

CELSR1 CELSR3

2.20e-03111212PF16489
DomainPKD1_2_channel

PKDREJ PKD1

2.20e-03111212IPR013122
DomainWD_REPEATS_1

POC1A EDC4 LYST SCAP WDR6 TLE6 GNB2

2.24e-032781217PS00678
DomainWD_REPEATS_2

POC1A EDC4 LYST SCAP WDR6 TLE6 GNB2

2.29e-032791217PS50082
DomainWD_REPEATS_REGION

POC1A EDC4 LYST SCAP WDR6 TLE6 GNB2

2.29e-032791217PS50294
DomainAtypical_DUSP

DUSP15 DUSP10

3.10e-03131212IPR020417
DomainWD40_repeat_dom

POC1A EDC4 LYST SCAP WDR6 TLE6 GNB2

3.24e-032971217IPR017986
Domain-

HSPG2 FAT1 CELSR1 CELSR3

3.39e-039512142.60.120.200
DomainLDLRA_1

HSPG2 LRP12 PKD1

3.71e-03481213PS01209
DomainLDLRA_2

HSPG2 LRP12 PKD1

3.93e-03491213PS50068
DomainASX_HYDROXYL

FAT1 CELSR1 CELSR3 FBN3

4.07e-031001214PS00010
DomainGPCR_Rhodpsn_7TM

DRD5 OR5V1 OR10H4 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

4.19e-0367012111IPR017452
DomainIG_LIKE

HSPG2 LILRA1 IGDCC3 IGSF10 NEO1 IL1R2 LRFN5 KIR3DL3 CDON

4.69e-034911219PS50835
DomainTLC

CLN8 TLCD4

4.71e-03161212SM00724
DomainTLC

CLN8 TLCD4

4.71e-03161212PS50922
DomainTRAM_LAG1_CLN8

CLN8 TLCD4

4.71e-03161212PF03798
DomainTLC-dom

CLN8 TLCD4

4.71e-03161212IPR006634
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT1 CELSR1 CELSR3 FBN3

5.01e-031061214IPR000152
DomainATPase_P-typ_cation-transptr_C

ATP13A3 ATP2A3

5.31e-03171212IPR006068
DomainCation_ATPase_C

ATP13A3 ATP2A3

5.31e-03171212PF00689
DomainLH2

PKDREJ PKD1

5.95e-03181212SM00308
DomainCation_ATPase_N

ATP13A3 ATP2A3

5.95e-03181212PF00690
DomainCTCK_1

CER1 MUC2

5.95e-03181212PS01185
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PTP

DUSP4 DUSP6 DUSP8 DUSP10

9.77e-0620984M47928
PathwayREACTOME_SIGNALING_BY_MAPK_MUTANTS

DUSP6 DUSP8 DUSP10

1.12e-057983M38997
PathwayREACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION

DUSP4 DUSP6 DUSP8 DUSP10

1.46e-0522984MM14506
PathwayREACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION

DUSP4 DUSP6 DUSP8 DUSP10

1.76e-0523984M26917
PathwayBIOCARTA_DSP_PATHWAY

DUSP4 DUSP6 DUSP8

2.65e-059983M22032
PathwayBIOCARTA_DSP_PATHWAY

DUSP4 DUSP6 DUSP8

2.65e-059983MM1554
PathwayREACTOME_SENSORY_PERCEPTION

HSPG2 LRP12 OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 CLPS OR10W1 KCNMA1 OR10K2 OR4C12 OR6T1

3.12e-056369815M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

1.48e-044179811M4072
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

DUSP4 DUSP6 DUSP8 DUSP10

2.01e-0442984MM15274
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

DUSP4 DUSP6 DUSP8 DUSP10

2.20e-0443984M27560
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 HSPG2 EP400 NSD2 EMID1 TMC6 EDC4 LYST FAT1 CELSR1 SCAP PSME4 CELSR3 PCNX4 CLN3 PKD1 HELZ2 DISP2 DEPDC5 SUFU ATP2A3 D2HGDH

1.10e-1011051282235748872
Pubmed

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.

DUSP4 DUSP6 DUSP8 NOX4 DUSP10

9.41e-0748128530938680
Pubmed

Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.

DUSP4 DUSP6 DUSP8 DUSP10

3.35e-0628128421533046
Pubmed

Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.

NPC1 CLN8 CLN3

4.02e-069128315647513
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

NSD2 DUSP6 GART CTRB2 FAT1 SACS WDR6 HELZ2 SHOC1

4.16e-06332128937433992
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5V1 OR10H4 OR10G6 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12

5.04e-06340128911875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5V1 OR10H4 OR10G6 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12

5.04e-06340128911802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5V1 OR10H4 OR10G6 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12

5.41e-06343128932295537
Pubmed

The human olfactory receptor gene family.

OR5V1 OR10H4 OR10G6 OR4S1 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12 OR6T1

5.51e-065411281114983052
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5V1 OR10H4 OR10G6 OR6B3 OR10G3 OR10G2 OR10W1 OR10K2 OR4C12

5.81e-06346128914611657
Pubmed

The family-wide structure and function of human dual-specificity protein phosphatases.

DUSP4 DUSP15 DUSP10

1.05e-0512128324531476
Pubmed

The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation.

CTRB2 CTRB1

1.34e-052128228951524
Pubmed

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

CTRB2 CTRB1

1.34e-052128228754779
Pubmed

Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival.

RPS27 RPS27L

1.34e-052128232779270
Pubmed

Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.

CTRB2 CTRB1

1.34e-05212822917002
Pubmed

Genomic cloning and partial characterization of human chymotrypsinogen gene.

CTRB2 CTRB1

1.34e-05212828186414
Pubmed

DUSP4 Inactivation Leads to Reduced Extracellular Signal‒Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells.

DUSP4 DUSP6

1.34e-052128235189148
Pubmed

SIRT1-NOX4 signaling axis regulates cancer cachexia.

NOX4 SIRT1

1.34e-052128232441762
Pubmed

Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis.

DUSP4 DUSP6

1.34e-052128237946160
Pubmed

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.

SIRT1 PKD1

1.34e-052128223778143
Pubmed

Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice.

CTRB2 CTRB1

1.34e-052128230076839
Pubmed

SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.

SIRT1 HERC4

1.34e-052128228856724
Pubmed

Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.

CTRB2 CTRB1

1.34e-052128233036922
Pubmed

Evolutionary relationships between laboratory mice and subspecies of Mus musculus based on the restriction fragment length variants of the chymotrypsin gene at the Prt-2 locus.

CTRB2 CTRB1

1.34e-05212822565717
Pubmed

Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL-7702 cells.

NOX4 SIRT1

1.34e-052128234939720
Pubmed

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.

HK1 HKDC1 G6PC2

2.63e-0516128323903356
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

HK1 GART HKDC1 MCM2 RPS27 EDC4 RPS27L NUDT5 FAR1 PYCR2 HERC4

3.71e-056651281130457570
Pubmed

A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.

DUSP4 LFNG CER1

3.82e-0518128318157121
Pubmed

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

LFNG PIK3CG

4.02e-053128225808869
Pubmed

Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8.

CTRB2 CTRB1

4.02e-05312821016231
Pubmed

The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.

CELSR1 CELSR3

4.02e-053128211677057
Pubmed

Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.

CTRB2 CTRB1

4.02e-053128234643096
Pubmed

Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice.

CTRB2 CTRB1

4.02e-053128232678161
Pubmed

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.

KCNMA1 MUC2

4.02e-053128233431687
Pubmed

Behavioral assessment in mouse models of neuronal ceroid lipofuscinosis using a light-cued T-maze.

CLN8 CLN3

4.02e-053128215885820
Pubmed

Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates.

RPS27 RPS27L

4.02e-053128237306301
Pubmed

GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT FERROPTOSIS.

NOX4 SIRT1

4.02e-053128238920138
Pubmed

Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.

CTRB2 CTRB1

4.02e-053128238981616
Pubmed

DNA methylation of MAPK signal-inhibiting genes in papillary thyroid carcinoma.

DUSP4 DUSP6

4.02e-053128224222120
Pubmed

Genetic study of pancreatic proteinase in mice (Mus musculus): genetic variants of trypsin and chymotrypsin.

CTRB2 CTRB1

4.02e-05312821008801
Pubmed

Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).

DUSP4 DUSP6

8.02e-05412829205128
Pubmed

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.

CELSR1 CELSR3

8.02e-054128237224017
Pubmed

Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity.

DUSP6 DUSP8

8.02e-054128232917360
Pubmed

Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator.

RPS27 RPS27L

8.02e-054128221170087
Pubmed

Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.

LFNG MET

8.02e-054128222624713
Pubmed

NCL disease mechanisms.

CLN8 CLN3

8.02e-054128223707513
Pubmed

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.

DUSP6 SIRT1

8.02e-054128221698133
Pubmed

Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors.

IGDCC3 NEO1

8.02e-054128210708514
Pubmed

Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6.

PIK3CG MUC2

8.02e-054128215733066
Pubmed

Developmental expression profiles of Celsr (Flamingo) genes in the mouse.

CELSR1 CELSR3

8.02e-054128211850187
Pubmed

Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.

SKP2 RNF123

8.02e-054128228601655
Pubmed

Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development.

DUSP4 DUSP6 DUSP8

8.17e-0523128323665221
Pubmed

SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.

DARS1 WDR6 FAR1 GNB2 PYCR2

8.48e-05120128537929963
Pubmed

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

MKS1 CC2D2A SUFU

1.06e-0425128327340223
Pubmed

Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse.

CTRB2 CTRB1

1.33e-04512826589791
Pubmed

CLN3p impacts galactosylceramide transport, raft morphology, and lipid content.

CLN8 CLN3

1.33e-045128218317235
Pubmed

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.

DIP2B DUSP10

1.33e-045128220972440
Pubmed

Neuronal ceroid lipofuscinosis: a common pathway?

CLN8 CLN3

1.33e-045128217237713
Pubmed

Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

HK1 G6PC2

1.33e-045128219096518
Pubmed

Local and cis effects of the H element on expression of odorant receptor genes in mouse.

OR10G3 OR10G2

1.33e-045128217662950
Pubmed

Polycystin channels and kidney disease.

PKDREJ PKD1

1.33e-045128211698076
Pubmed

Genetic study of pancreatic proteinase and alpha-amylase in mice (Mus musculus).

CTRB2 CTRB1

1.33e-04512824461036
Pubmed

Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways.

NOX4 SIRT1

1.33e-045128225116588
Pubmed

Inactivation of muscle chloride channel by transposon insertion in myotonic mice.

MET CLCN1

1.33e-04512821659665
Pubmed

Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1.

CTRB2 CTRB1

1.33e-04512821820020
Pubmed

USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.

GART RPS27 RPS27L WDR6

1.57e-0473128430224337
Pubmed

Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.

DUSP4 DUSP8 DUSP10

1.84e-0430128317699753
Pubmed

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

SKP2 SIRT1

2.00e-046128221841822
Pubmed

Batten's disease: clues to neuronal protein catabolism in lysosomes.

CLN8 CLN3

2.00e-046128210740217
Pubmed

Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.

MET PKD1

2.00e-046128220852388
Pubmed

Intronic delay is essential for oscillatory expression in the segmentation clock.

DUSP4 LFNG

2.00e-046128221300886
Pubmed

Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.

CTRB2 CTRB1

2.00e-046128223814066
Pubmed

Dystroglycan is a scaffold for extracellular axon guidance decisions.

CELSR1 CELSR3

2.00e-046128230758284
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

DIP2B NECAB2 DUSP4 TMC6 EDC4 MKS1 STARD6 USP42 IL1R2 PIK3CG MROH7 CC2D2A PYCR2 PLXNA2

2.01e-0412421281430973865
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

NPC1 RHBDD2 MCM2 DARS1 RPS27 RPS27L FAT1 NEO1 SCAP WDR6 FAR1 PYCR2

2.14e-049521281238569033
Pubmed

Hereditary Dystonia Overview

NPC1 CLN8 CLN3 D2HGDH

2.45e-0482128420301334
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

HK1 EP400 MKS1 RPS27L PSME4 PKD1 KCNMA1 CC2D2A FAR1

2.52e-04564128921565611
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

DIP2B DUSP4 DUSP6 MCM2 TNS2 DUSP15 SIRT1 WDR6 DUSP10 FAR1 PYCR2 SUFU

2.64e-049741281228675297
Pubmed

Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.

CELSR1 CELSR3

2.79e-047128217937400
Pubmed

A module of negative feedback regulators defines growth factor signaling.

DUSP4 DUSP6

2.79e-047128217322878
Pubmed

Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis.

DUSP4 LFNG

2.79e-047128218579680
Pubmed

Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis.

DUSP4 LFNG

2.79e-047128221632822
Pubmed

A complex oscillating network of signaling genes underlies the mouse segmentation clock.

HSPG2 DUSP6 LFNG

3.45e-0437128317095659
Pubmed

Case-control genome-wide association study of attention-deficit/hyperactivity disorder.

HK1 HKDC1

3.71e-048128220732627
Pubmed

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins.

CLN8 CLN3

3.71e-048128219941651
Pubmed

Netrins and neogenin promote myotube formation.

NEO1 CDON

3.71e-048128215520228
Pubmed

A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.

DUSP6 DUSP10

3.71e-048128211359773
Pubmed

Expression and functional role of hepatocyte growth factor and its receptor (c-met) during fetal mouse testis development.

MET HSD3B2

3.71e-048128217170214
Pubmed

Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.

RNF123 PKD1

3.71e-048128225907116
Pubmed

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

RPS27 PKDREJ RPS27L MET GNB2 ATP2A3

3.85e-04256128624189400
Pubmed

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.

GART RNF123 KCNMA1 MFSD3

4.13e-0494128425201988
Pubmed

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.

MKS1 MET CELSR1 PKD1

4.30e-0495128420843830
Pubmed

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.

CTRB2 CLPS CTRB1

4.69e-0441128323676500
Pubmed

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.

DUSP6 DUSP8

4.76e-049128230964448
Pubmed

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.

MET PIK3CG

4.76e-049128210871282
Pubmed

A growing family of dual specificity phosphatases with low molecular masses.

DUSP8 DUSP15

4.76e-049128211432789
Pubmed

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.

RPS27 RPS27L

4.76e-049128225144937
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

NSD2 DUSP4 DUSP6 DUSP8 TNS2 RPS27L NUDT5 KCNMA1 USP12 DUSP10 PYCR2 SUFU

5.12e-0410491281227880917
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

HK1 EP400 INTS7 MCM2 PRDM2

5.15e-04177128526206133
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

PSME4 PKD1 CC2D2A SUFU

5.22e-04100128425807483
InteractionTOP3B interactions

NPC1 HSPG2 POC1A EP400 NSD2 EMID1 TMC6 DARS1 EDC4 LYST FAT1 CELSR1 SCAP PSME4 CELSR3 PCNX4 CLN3 PKD1 HELZ2 DISP2 DEPDC5 SUFU ATP2A3 D2HGDH

3.20e-06147011724int:TOP3B
Cytoband15q22.3-q23

IGDCC3 NEO1

4.61e-054128215q22.3-q23
GeneFamilyMAP kinase phosphatases

DUSP4 DUSP6 DUSP8 DUSP10

2.02e-0711924895
GeneFamilyOlfactory receptors, family 10

OR10H4 OR10G6 OR10G3 OR10G2 OR10W1 OR10K2

1.05e-0666926157
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3

7.66e-053922913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3

7.66e-0539221189
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 IGDCC3 IGSF10 NEO1 LRFN5 CDON

1.72e-04161926593
GeneFamilyTLC domain containing

CLN8 TLCD4

1.12e-03109221374
GeneFamilyWD repeat domain containing

POC1A LYST SCAP WDR6 TLE6 GNB2

2.20e-03262926362
CoexpressionGSE12198_NK_VS_NK_ACT_EXPANSION_SYSTEM_DERIVED_NK_CELL_DN

INTS7 HKDC1 MCM2 LFNG ANKRD44 NUDT5 PYCR2 HERC4

4.04e-062001208M7065
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZYG11A CELSR1 CLPS TLE6 CTRB1 NR1I3

9.96e-061731266c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZYG11A CELSR1 CLPS TLE6 CTRB1 NR1I3

9.96e-061731266f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCellfacs-Tongue-nan-18m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRPL52 RPS27 RPS27L CLPS GNB2 CTRB1

1.60e-051881266a2fda11bba33ddefa48f93dd635e254d1a081218
ToppCellfacs-Tongue-nan-18m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRPL52 RPS27 RPS27L CLPS GNB2 CTRB1

1.60e-0518812661b3f71de4631403938a9dc85a02af2feea0b919f
ToppCell3'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HKDC1 MCM2 LFNG HELZ2 C12orf76 MUC2

1.65e-0518912667dad62bd50c197838058e89abd0ee387de3e83cd
ToppCellMS-Treg-exh_CD4|MS / Condition, Cell_class and T cell subcluster

DIP2B DUSP4 GART DEPDC5 ATP2A3 KIF1C

1.80e-051921266c6722bf142c84ccedd99c1a3344085aecb4cbab4
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 GPAM STARD6 IGSF10 FAT1 CDON

1.85e-05193126664edc1d6fb0fe117767d494cf4a5723bf8be2804
ToppCellfacs-Tongue-nan-18m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRPL52 RPS27 RPS27L CLPS GNB2 CTRB1

1.85e-05193126645361266b5c6e9b229ef80ef692f01b48e5b38ed
ToppCellBAL-Severe-Myeloid-MoAM-MoAM5-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DUSP4 DUSP6 RPS27 RPS27L IL1R2 KCNMA1

1.91e-051941266c53478057674d70b79df8a3f476d15dea1925753
ToppCellBAL-Severe-Myeloid-MoAM-MoAM5|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DUSP4 DUSP6 RPS27 RPS27L IL1R2 KCNMA1

1.91e-0519412662ab3f75b795a0ee4fe0f8eeba33093fcc77935f5
ToppCellBAL-Severe-Myeloid-MoAM-MoAM5-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DUSP4 DUSP6 RPS27 RPS27L IL1R2 KCNMA1

1.91e-0519412668805c90e4284a81a6c8078f2d2417ae77b4e5c63
ToppCellBAL-Severe-Myeloid-MoAM-MoAM5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DUSP4 DUSP6 RPS27 RPS27L IL1R2 KCNMA1

1.91e-05194126686d52467b05a0018517377c9c441245501f71d91
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMID1 PLPPR4 DISP2 G6PC2 PYCR2 ATP2A3

1.96e-051951266bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellTCGA-Thryoid-Primary_Tumor|TCGA-Thryoid / Sample_Type by Project: Shred V9

DUSP4 DUSP6 TMC6 RHBDD2 RPS27L MET

1.96e-0519512667cdee2ae90edf15e4cbcf70797b8caf1f037b0ef
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma|TCGA-Thryoid / Sample_Type by Project: Shred V9

DUSP4 DUSP6 TMC6 RHBDD2 RPS27L MET

1.96e-051951266b61b8c931bd0ca3678486653ae1d7e9915c696c7
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL1R2 KCNMA1 B4GALNT2 DISP2 MUC2 ATP2A3

2.02e-051961266847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell343B-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 NSD2 DUSP4 LYST LFNG MET

2.08e-051971266ec92d60f802c9d4bdf9877bed5c0a91a5a5ed5d0
ToppCell343B-Endothelial_cells-Endothelial-A_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 NSD2 DUSP4 LYST LFNG MET

2.08e-0519712667bec9c1bc8851064eb229324493b47a31201c83c
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

SKP2 FAT1 CELSR1 USP42 ATP13A3 CDON

2.20e-051991266358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellfacs-MAT-Fat-18m-Epithelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS11 HKDC1 B4GALNT2 HSD3B2 NR1I3

5.60e-05144126565ffd8a1620b178d995fe8c913871f0b376b896f
ToppCellfacs-MAT-Fat-18m-Epithelial-epithelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS11 HKDC1 B4GALNT2 HSD3B2 NR1I3

5.60e-051441265fd852095dcd716ac53b0fd25d83e6f454b2ae794
ToppCellmetastatic_Brain-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

LILRA1 RPS27 LFNG IL1R2 PYCR2

5.60e-0514412656f1158c85e1d50ef6f2c67abdb2dc855a9786b9a
ToppCellfacs-MAT-Fat-18m-Epithelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS11 HKDC1 B4GALNT2 HSD3B2 NR1I3

5.60e-051441265e4e148007c772cd163a34fb172e05184f7352a2b
ComputationalGrowth suppressors.

DUSP4 DUSP6 DUSP8

6.05e-0513663MODULE_407
ComputationalGenes in the cancer module 173.

DUSP4 DUSP6 DUSP8

1.17e-0416663MODULE_173
Drugfluorescein dilaurate

DUSP4 CTRB2 CLPS CTRB1

8.57e-07141264CID000081743
DrugBOCPheONP

CTRB2 CTRB1

3.04e-0521262CID000111308
DrugMPM-06

CTRB2 CTRB1

3.04e-0521262CID000161546
DrugNSC-374899

CTRB2 CTRB1

3.04e-0521262CID000435726
Drugmethylbenzenebutanoate

CTRB2 CTRB1

3.04e-0521262CID000281254
DrugAsp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu

CTRB2 CTRB1

3.04e-0521262CID004418081
Drugc189

CTRB2 CTRB1

3.04e-0521262CID000248048
Drugdansyl-D-arginine methyl ester

CTRB2 CTRB1

3.04e-0521262CID000191369
Drugmethyl 6-phenylhexanoate

CTRB2 CTRB1

3.04e-0521262CID011820300
Drug5-aminotetrazole

CTRB2 CTRB1

3.04e-0521262CID000020467
Drug2-bromoisobutyric acid

CTRB2 CTRB1

3.04e-0521262CID000074924
Drugp-toluamidine

CTRB2 CTRB1

3.04e-0521262CID000122753
DrugN-acetyl-alpha-azaphenylalanine phenyl ester

CTRB2 CTRB1

3.04e-0521262CID000191275
Drugisobutyl sulfide

CTRB2 CTRB1

3.04e-0521262CID000011607
Drugdiisopropyl

CTRB2 F11 CLPS CTRB1

4.59e-05361264CID000006589
Drugepicholesterol

NPC1 HSPG2 LRP12 GPAM LYST F11 STARD6 SCAP KCNMA1 HSD3B2 G6PC2 ATP2A3 NR1I3

5.30e-0563612613CID000000304
DrugN-acetylbenzotriazole

CTRB2 CTRB1

9.08e-0531262CID000087784
Drugphotophor

CTRB2 CTRB1

9.08e-0531262CID000014780
Drugdibutyl iodomethaneboronate

CTRB2 CTRB1

9.08e-0531262CID000098591
Drugzinc;dipicolinate

CTRB2 CTRB1

9.08e-0531262CID004309911
Drug2-oxobut-3-ynoate

CTRB2 CTRB1

9.08e-0531262CID000171547
DrugAFMeq

CTRB2 CTRB1

9.08e-0531262CID000194069
DrugBz-Cti-otbu

CTRB2 CTRB1

9.08e-0531262CID006452691
Drugn-(2-oxoethyl)benzamide

CTRB2 CTRB1

9.08e-0531262CID000188995
DrugAC1L49DM

CTRB2 CTRB1

9.08e-0531262CID000152933
Drugc140

CTRB2 CTRB1

9.08e-0531262CID002783250
DrugBenzamidomethaneboronic acid

CTRB2 CTRB1

9.08e-0531262CID000127677
Drugphenyl hippurate

CTRB2 CTRB1

9.08e-0531262CID000076323
DrugFK-386

CTRB2 CTRB1

9.08e-0531262CID000135044
DrugFK-375

CTRB2 CTRB1

9.08e-0531262CID000135042
Drugcarbostyril-124

CTRB2 CTRB1

9.08e-0531262CID000088277
DrugN-trifluoroacetyl-4-fluorophenylalanine

CTRB2 CTRB1

9.08e-0531262CID000328214
DrugC18 4

CTRB2 CTRB1

9.08e-0531262CID000077248
Drugtaraxastane

CTRB2 CTRB1

9.08e-0531262CID006429404
DrugPhe-phe-ome

CTRB2 CTRB1

9.08e-0531262CID000151728
Drugphenylethaneboronic acid

CTRB2 CTRB1

9.08e-0531262CID000065389
Drug3-amino-2-pyridone

CTRB2 CTRB1

9.08e-0531262CID000322353
DrugASA-BMPA

CTRB2 CTRB1

9.08e-0531262CID003035649
Drugp-nitrophenyl benzoate

CTRB2 CTRB1

9.08e-0531262CID000070396
DrugZ-Phe-OMe

CTRB2 CTRB1

9.08e-0531262CID003082435
Drug3-methylcoumarin

CTRB2 CTRB1

9.08e-0531262CID000017130
Drug2-propyl methylphosphonochloridate

CTRB2 CTRB1

9.08e-0531262CID000102124
DrugFK-316

CTRB2 CTRB1

9.08e-0531262CID000133688
DrugAC1L19T8

CTRB2 CTRB1

9.08e-0531262CID000000694
DrugMarinostatin D

CTRB2 CTRB1

9.08e-0531262CID000132206
Drug1FD7

CTRB2 CTRB1

9.08e-0531262CID000445579
DrugGlt-leu-phe-nh-meq

CTRB2 CTRB1

9.08e-0531262CID000194914
DrugAC1L4Z4F

CTRB2 CTRB1

9.08e-0531262CID000194913
DrugGlt-Phe-NH-FMeq

CTRB2 CTRB1

9.08e-0531262CID000194912
Drugdiacetyl trimer

CTRB2 CTRB1

9.08e-0531262CID000193527
DrugFK-448

CTRB2 CTRB1

9.08e-0531262CID006917869
DrugAc-Phe-OMe

CTRB2 CTRB1

9.08e-0531262CID000097805
Drugthiobenzyl N-heptafluorobutyrylanthranilate

CTRB2 CTRB1

9.08e-0531262CID000133906
DrugAC1L2TMY

HK1 CTRB2 CTRB1

1.06e-04171263CID000102826
DrugHesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A

LRP12 LYST CELSR3 DUSP10 KIF3C ATP2A3 HERC4

1.09e-0419512675313_UP
DrugProglumide [6620-60-6]; Down 200; 12uM; MCF7; HT_HG-U133A

LRP12 DUSP4 MET PSME4 KIF3C HERC4 CDON

1.09e-0419512673972_DN
Drug5286656; Up 200; 50uM; MCF7; HT_HG-U133A_EA

DUSP6 CELSR3 IL1R2 KCNMA1 DEPDC5 DUSP10 KIF3C

1.09e-041951267889_UP
DrugDipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

TMC6 EDC4 SKP2 PRDM2 MKS1 CELSR1 KIF3C

1.12e-0419612677124_DN
DrugY-27632; Down 200; 3uM; MCF7; HT_HG-U133A_EA

CLN8 INTS7 GART PRDM2 FOXRED2 PCNX4 HERC4

1.12e-041961267832_DN
DrugQuinic acid [86-68-0]; Up 200; 19.6uM; MCF7; HT_HG-U133A

LRP12 DUSP6 TMC6 TNS2 DEPDC5 MUC2 ATP2A3

1.16e-0419712673540_UP
DrugThalidomide [50-35-1]; Down 200; 15.4uM; PC3; HT_HG-U133A

LRP12 NSD2 GART MET PSME4 CLN3 ATP13A3

1.16e-0419712672095_DN
DrugNitrarine dihydrochloride [20069-05-0]; Down 200; 10.6uM; PC3; HT_HG-U133A

CLN8 NSD2 TMC6 DUSP10 ATP13A3 HERC4 PLXNA2

1.16e-0419712673683_DN
DrugChlorhexidine [55-56-1]; Down 200; 8uM; PC3; HT_HG-U133A

GART TNS2 PRDM2 MET PSME4 PLPPR4 PLXNA2

1.19e-0419812676302_DN
DrugAjmalicine hydrochloride [4373-34-6]; Up 200; 10.2uM; HL60; HG-U133A

LRP12 DUSP4 TMC6 MKS1 RNF123 PIK3CG CLPS

1.19e-0419812671748_UP
DrugNomifensine maleate [32795-47-4]; Down 200; 11.2uM; PC3; HT_HG-U133A

CLN8 HSPG2 GART SKP2 PRDM2 MET KIF3C

1.19e-0419812672062_DN
DrugPHA-00851261E [724719-49-7]; Up 200; 10uM; PC3; HT_HG-U133A

FOXRED2 PSME4 G6PC2 MUC2 ATP2A3 PLXNA2 KIF1C

1.27e-0420012673773_UP
DrugAC1L3U1M

NPC1 GPAM CDON

1.50e-04191263CID000122133
DrugAC1L3JHX

CTRB2 PKDREJ PRDM2 CLN3 PKD1 CTRB1

1.64e-041461266CID000090206
DrugBenzoyl-dl-leucine

CTRB2 CTRB1

1.81e-0441262CID000294887
DrugAcafcek

CTRB2 CTRB1

1.81e-0441262CID000197677
DrugB-1,3-od

CTRB2 CTRB1

1.81e-0441262CID011971053
Drugdehydromerodesmosine

CTRB2 CTRB1

1.81e-0441262CID006443540
Drugalpha-amyrin palmitate

CTRB2 CTRB1

1.81e-0441262CID000185477
Drugpoly-THIQ

CTRB2 CTRB1

1.81e-0441262CID006453487
DrugN-(4-carboxycyclohexylmethyl)-maleimide

CTRB2 CTRB1

1.81e-0441262CID011548799
DrugG2505_sigma

CTRB2 CTRB1

1.81e-0441262CID000111098
Drugp-fluorobenzenesulfonyl chloride

CTRB2 CTRB1

1.81e-0441262CID000009588
DrugBSSDA

CTRB2 CTRB1

1.81e-0441262CID003081106
DrugAC1L2HV6

CTRB2 CTRB1

1.81e-0441262CID000047328
DrugAC1L4X1Z

CTRB2 CTRB1

1.81e-0441262CID000193815
DrugNSC-676827

CTRB2 CTRB1

1.81e-0441262CID000385555
Drug6-amino-1,2-benzopyrone

CTRB2 CTRB1

1.81e-0441262CID000046152
Drugnitrophenylethanol

CTRB2 CTRB1

1.81e-0441262CID000097851
Drug3-Cl

CTRB2 F11 CTRB1

2.05e-04211263CID000012313
DrugN-carbobenzoxy-l-alanine

CTRB2 CTRB1 SUFU

2.36e-04221263CID000070832
DrugAc-Trp-OEt

CTRB2 CTRB1

3.01e-0451262CID000304749
Drugapne

CTRB2 CTRB1

3.01e-0451262CID000098192
Drug7-chloro-4-nitrobenzofuran

CTRB2 CTRB1

3.01e-0451262CID000130782
DrugZ-Phe-Leu

CTRB2 CTRB1

3.01e-0451262CID000333351
Drug5'-FSBAzA

CTRB2 CTRB1

3.01e-0451262CID000130430
DrugAC1L3F57

CTRB2 CTRB1

3.01e-0451262CID000139565
Drugtrichlorosilane

HK1 CDON

3.01e-0451262CID000140487
Drug3,5-dimethylpyrazole-1-carboxamidine

CTRB2 CTRB1

3.01e-0451262CID000097525
DrugMaap-borov

CTRB2 CTRB1

3.01e-0451262CID005486914
Drug2-amino-4,6-dichlorotriazine

CTRB2 CTRB1

3.01e-0451262CID000013615
DrugAC1O52A0

CTRB2 CTRB1

3.01e-0451262CID006475891
Drugallysine aldol

CTRB2 CTRB1

3.01e-0451262CID000191270
Diseasepancreatitis (biomarker_via_orthology)

DUSP6 CTRB2 MET DUSP10 CTRB1

5.06e-07391195DOID:4989 (biomarker_via_orthology)
Diseaselevel of chymotrypsinogen B2 in blood serum

CTRB2 CTRB1

1.61e-0521192OBA_2041192
DiseaseGastrointestinal Stromal Sarcoma

NPC1 CC2D2A SUFU CDON

3.92e-05471194C3179349
Diseasechymotrypsinogen B measurement

CTRB2 CTRB1

4.83e-0531192EFO_0801477
DiseaseGastrointestinal Stromal Tumors

NPC1 CC2D2A SUFU CDON

5.02e-05501194C0238198
DiseaseJuvenile neuronal ceroid lipofuscinosis

CLN8 CLN3

9.63e-0541192cv:CN293564
DiseaseCongenital myotonia

HSPG2 CLCN1

9.63e-0541192cv:CN295225
DiseasePolycystic Kidney - body part

MKS1 PKD1

1.60e-0451192C1567435
Diseasetumor necrosis factor ligand superfamily member 6, soluble form measurement

RNF123 CELSR3

3.34e-0471192EFO_0020797
DiseaseHbA1c measurement

DIP2B HK1 TMC6 CTRB2 HKDC1 RNF123 OR4S1 G6PC2 CTRB1 KIF1C

4.18e-0467511910EFO_0004541
DiseaseMeckel syndrome (implicated_via_orthology)

MKS1 CC2D2A

4.44e-0481192DOID:0050778 (implicated_via_orthology)
Diseasethioredoxin domain-containing protein 12 measurement

RNF123 SCAP CELSR3

5.26e-04391193EFO_0008298
DiseaseNeuronal ceroid lipofuscinosis

CLN8 CLN3

5.70e-0491192cv:C0027877
Diseaseretinitis pigmentosa (is_implicated_in)

HK1 HKDC1 CC2D2A

6.10e-04411193DOID:10584 (is_implicated_in)
DiseaseChildhood Medulloblastoma

SKP2 PIK3CG SUFU

7.02e-04431193C0278510
DiseaseMelanotic medulloblastoma

SKP2 PIK3CG SUFU

7.02e-04431193C1275668
DiseaseMedullomyoblastoma

SKP2 PIK3CG SUFU

7.02e-04431193C0205833
DiseaseDesmoplastic Medulloblastoma

SKP2 PIK3CG SUFU

7.02e-04431193C0751291
DiseaseAdult Medulloblastoma

SKP2 PIK3CG SUFU

7.02e-04431193C0278876
DiseaseMeckel-Gruber syndrome

MKS1 CC2D2A

7.11e-04101192cv:C0265215
Diseasetrypsin-2 measurement

CTRB2 CTRB1

8.66e-04111192EFO_0008305
Diseasenon-alcoholic fatty liver disease

HK1 GPAM MET PLPPR4 KCNMA1

8.75e-041821195EFO_0003095
DiseaseStreptozotocin Diabetes

HK1 GPAM SIRT1 ATP2A3

9.76e-041081194C0038433
DiseaseDiabetes Mellitus, Experimental

HK1 GPAM SIRT1 ATP2A3

9.76e-041081194C0011853
DiseaseAlloxan Diabetes

HK1 GPAM SIRT1 ATP2A3

9.76e-041081194C0002152
DiseaseMedulloblastoma

SKP2 PIK3CG SUFU

1.09e-03501193C0025149
Diseaseneuronal ceroid lipofuscinosis (implicated_via_orthology)

CLN3 ATP13A3

1.42e-03141192DOID:14503 (implicated_via_orthology)
Diseasethalamus volume change measurement

FAT1 LRFN5

1.42e-03141192EFO_0021496
DiseaseObesity

NPC1 SIRT1 MKS1 KCNMA1 NR1I3

1.48e-032051195C0028754
DiseaseMeckel-Gruber syndrome

MKS1 CC2D2A

1.64e-03151192C0265215
Diseasepre-malignant neoplasm (biomarker_via_orthology)

SUFU MUC2

2.11e-03171192DOID:0060071 (biomarker_via_orthology)
Diseasecholangiocarcinoma (is_marker_for)

MET IL1R2 MUC2

2.23e-03641193DOID:4947 (is_marker_for)
DiseaseMeckel syndrome type 1

MKS1 CC2D2A

2.37e-03181192C3714506
DiseaseMetabolic Syndrome X

SIRT1 NR1I3

3.22e-03211192C0524620
Diseasechronic widespread pain

DIP2B CDON

3.86e-03231192EFO_0010099

Protein segments in the cluster

PeptideGeneStartEntry
VTAAHCGVRTSDVVV

CTRB2

71

Q6GPI1
IFCAILSTHSRTTGI

EP400

1966

Q96L91
TACIIDVFGVTHRES

HSD3B2

81

P26439
CVVTSGVVNFFLAHT

B4GALNT2

466

Q8NHY0
RHTLFCGTTVIQTRF

ATP13A3

356

Q9H7F0
QVIVHCLAGISRSAT

DUSP8

241

Q13202
SDGIHSVTAFCTLRV

CELSR1

1181

Q9NYQ6
RFLTCQGVSSLLQVH

DNHD1

2191

Q96M86
TCRTVPFSQTITHEG

CER1

161

O95813
GTATLNQTIDICRHF

FBN3

401

Q75N90
IRSHTSFGALCQRTA

DISP2

316

A7MBM2
FGRQLSHAISVICVA

ATP2A3

256

Q93084
RSELVNVCVHSVFSL

MROH7

501

Q68CQ1
IQASRGQTVTFTCVA

HSPG2

416

P98160
SHFCSRTPVETVNIS

DRD5

376

P21918
THPVLSFGIQVVSRC

EDC4

456

Q6P2E9
AHGVRVLTNITVSCQ

INTS7

361

Q9NVH2
NRAVSTCYSHITIVV

OR4M2B

236

A0A0X1KG70
SLTATRVVGCIQFTT

LRFN5

496

Q96NI6
HLNQLIRTSGVVTSC

MCM2

301

P49736
GAAVEICHIVLNTTF

NR1I3

196

Q14994
NCSHEVTVVLFSRTF

DEPDC5

211

O75140
VFRSSTQVHVTVIGG

FAT1

2471

Q14517
VRSVHFCSDGQSFVT

POC1A

106

Q8NBT0
TGNILIVVSIHTETC

OR10W1

31

Q8NGF6
VCIDTHTLGLFVAVN

OR4C12

186

Q96R67
IIDSTNIIFHCAATV

FAR1

101

Q8WVX9
IFHCVASNIASIRIS

IGDCC3

206

Q8IVU1
LTVVSSSGQIRVHFC

LRP12

341

Q9Y561
LARHTGNVVITNCSA

LFNG

156

Q8NES3
VVCGHITLESVSNFL

KCNMA1

411

Q12791
IHCQAGVSRSATIVI

DUSP10

406

Q9Y6W6
SHAIFIITVECSERG

KIF3C

216

O14782
LHSVSVCIGFTRAFR

PCNX4

471

Q63HM2
RFAASISQCVSLAVH

PLXNA2

551

O75051
RRKAVSTCGSHVITV

OR4S1

231

Q8NGB4
LSNCTIHIVTVTING

NUDT5

136

Q9UKK9
SFETCRTINGIHSNI

MUC2

1141

Q02817
VTEIACGRQHTSAFV

HERC4

296

Q5GLZ8
GTVVSEGQHVTLQCR

KIR3DL3

36

Q8N743
IASNSIICTAHFTAR

NSD2

806

O96028
AVSTTFGSRVNVAIC

DIP2B

1311

Q9P265
FTIVFTQRCHDQLTG

KIF1C

221

O43896
HDNIICGITSVAFSR

GNB2

266

P62879
FHCIETLVTTGANVN

ANKRD44

451

Q8N8A2
RRAFSTCGAHVTVVT

OR10G3

236

Q8NGC4
TIVGSITNTNFGICH

CLPS

91

P04118
QVHQCSVLFVATGLS

FOXRED2

171

Q8IWF2
VQHVCTIVSFRSANL

HK1

371

P19367
FSGIHLLRCFIASVT

GTPBP8

266

Q8N3Z3
CLQHFLGGLVTTVTF

MFSD3

326

Q96ES6
SIEGVRHVFSRACTI

PRPF39

401

Q86UA1
SRTFHITCGVTICIF

NOX4

101

Q9NPH5
LQSVCHTVVVQGVSA

GRIN3A

181

Q8TCU5
TTIVFHLTFCGSNVI

OR10H4

161

Q8NGA5
ITACSSGLVFVRVTT

NPC1

361

O15118
AGFLNSVVHTVLTFC

OR5V1

151

Q9UGF6
RSIVTRTGAAFQLHC

IGSF10

2536

Q6WRI0
PFVEVSFQRTVCHTT

CC2D2A

1101

Q9P2K1
VITDIHVGSRINYSC

CR1L

426

Q2VPA4
CLVHCFAGISRSTTI

DUSP15

81

Q9H1R2
QIVSLGATVHFTCDV

CDON

321

Q4KMG0
CSQGLVSNVVFTSHT

DNAAF9

881

Q5TEA3
QVVHFILFTSVSGEC

F11

6

P03951
QISVCISRVFIATHF

G6PC2

161

Q9NQR9
LSSTCVQILSGVHNI

LYST

566

Q99698
EVHGSFTCSITVQLS

DHDH

221

Q9UQ10
SHTLIQLERCFTATG

KHDC1L

51

Q5JSQ8
VTRTISCHVQNGTYL

EMID1

41

Q96A84
VTVTDGLHSVTAQCV

CELSR3

1246

Q9NYQ7
QFRVVVLSTVHTCQS

HELZ2

866

Q9BYK8
FSAIRSQHSGVDICI

DHRS11

81

Q6UWP2
VHCLAGISRSVTVTV

DUSP6

291

Q16828
VLVHCQAGISRSATI

DUSP4

276

Q13115
CLFTLQGHSGAITTV

SCAP

1111

Q12770
FSLCGHRLIIFTQSV

SACS

1676

Q9NZJ4
VTAAHCGVRTSDVVV

CTRB1

71

P17538
VLSFHSVSGILVCQA

D2HGDH

156

Q8N465
LVSTVCNFGVVRTLT

LRRC43

581

Q8N309
TTHNIPQTFTTAIRC

PRDM2

1321

Q13029
NTTVRGCPTVTHNFT

PKD1

1336

P98161
RAFSTCGSHLIVVTV

OR10G2

241

Q8NGC3
RNAFSTCAAHLTVVI

OR10G6

256

Q8NH81
CGFTVAQIITSLVFH

OR10K2

151

Q6IF99
TRIIRFCSINSGLHS

MET

276

P08581
TVLFTGVRRLHCSVA

MRPL52

6

Q86TS9
VQHVCTIVSFRSANL

HKDC1

371

Q2TB90
VTLHCVSQVAFGSFI

LILRA1

141

O75019
VFSHAQTVVLCVGCS

RPS27L

46

Q71UM5
FVQLRGTVSTSDVHC

PKDREJ

1251

Q9NTG1
AIQLLGNCVTITHTS

GPAM

536

Q9HCL2
VIIAVFCTRRTTSHQ

NEO1

1121

Q92859
VLRGTSSCVVVHNQY

SHOC1

786

Q5VXU9
IQRIIQCHGSFATAS

SIRT1

356

Q96EB6
VQARHIVVSCAAGVT

PYCR2

86

Q96C36
LTGDHTISFVSCIIQ

OR6T1

86

Q8NGN1
CASHLTVVVIIYGSS

OR6T1

241

Q8NGN1
TSQAVFRLQSGICHL

DARS1

191

P14868
RAFFTCASHLTVVTV

OR6B3

236

Q8NGW1
CVVHNTLSFQTLRTT

IL1R2

326

P27930
TFICHTITQSFAVGS

STARD6

91

P59095
HSVGTSLCGVVFASI

CLN3

146

Q13286
LGVFVVCHQLSSSLN

CLN8

36

Q9UBY8
LGQASRFIHTTVCSA

C12orf76

46

Q8N812
STAVICFELTGQIAH

CLCN1

541

P35523
ANNCIFIVIHRSTTS

PIK3CG

216

P48736
SVIEVSTLHGILSQC

SKP2

191

Q13309
VHVFGLCSTALITDI

PLPPR4

181

Q7Z2D5
DRHTQATTLVCQIFG

USP42

221

Q9H9J4
ETTGTVTFRLHCLQQ

MKS1

481

Q9NXB0
ERTVGTVRHCFFTVI

RHBDD2

91

Q6NTF9
IGHSNFGTIRSTTCV

RNF123

116

Q5XPI4
RVCAGTATFHLLQAV

SERINC4

121

A6NH21
TFLQIVGVCTEELHS

SUFU

196

Q9UMX1
VEQNTSITHCLRGFS

USP12

206

O75317
SRVVSTCHSLVVGIF

TLCD4

51

Q96MV1
ALTAVCNHISSVRAV

WDR6

766

Q9NNW5
HQLTATLSCVIGVAR

PSME4

451

Q14997
ALETGVTVTGCTVHF

GART

931

P22102
ITETGRQVTLACHQT

TRBV10-1

31

A0A0K0K1A3
RVGSTSGIHAITVFC

TMC6

371

Q7Z403
TGLRILSVFNVCFHT

ZYG11A

181

Q6WRX3
VFSHAQTVVLCVGCS

RPS27

46

P42677
TDRTLVFRVQFHTCT

TNS2

376

Q63HR2
GSVTRDSIFRLHVSC

ZP4

271

Q12836
ATAISSFTRHVFTCG

TLE6

291

Q9H808
HSLDVIGFLLVCVTT

UGT2A2

496

P0DTE5
TQVVCTAFSSHILVV

PSMG3

21

Q9BT73
RGTTGVRNCFHITAV

NECAB2

311

Q7Z6G3