Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.66e-06	5	111	3	GO:0030156
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A13	9.15e-05	3	111	2	GO:0008389
GeneOntologyMolecularFunction	actinin binding	MAGI1 RELA CSRP3 ALMS1	9.44e-05	43	111	4	GO:0042805
GeneOntologyCellularComponent	manchette	RIMBP3 CFAP221 RIMBP3C RIMBP3B	1.45e-05	28	112	4	GO:0002177
GeneOntologyCellularComponent	microtubule	CYP2A6 CYP2A13 WHAMM NCKAP5 BOD1L2 ZNF804A TRIP10 CEP170 TPX2 CDK5RAP2 KIF4B	1.38e-04	533	112	11	GO:0005874
MousePheno	ectopic manchette	IQCN RIMBP3 RIMBP3C RIMBP3B	8.12e-06	19	98	4	MP:0009377
MousePheno	abnormal sperm nucleus morphology	HIPK4 KMT2E RIMBP3 CCDC87 RIMBP3C RIMBP3B	1.28e-05	74	98	6	MP:0009232
MousePheno	detached acrosome	HIPK4 KMT2E RIMBP3 RIMBP3C RIMBP3B	1.34e-05	44	98	5	MP:0009231
MousePheno	impaired fertilization	HIPK4 KDM3B IQCN KMT2E RIMBP3 CCDC87 RIMBP3C ADAM2 RIMBP3B	1.39e-05	206	98	9	MP:0000242
MousePheno	abnormal acrosome morphology	HIPK4 SOX30 IQCN KMT2E RIMBP3 CCDC87 RIMBP3C RIMBP3B	1.55e-05	159	98	8	MP:0008898
MousePheno	abnormal fertilization	HIPK4 KDM3B IQCN KMT2E RIMBP3 CCDC87 RIMBP3C ADAM2 RIMBP3B	2.44e-05	221	98	9	MP:0005410
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.33e-07	4	113	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	3.32e-07	5	113	3	17855024
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	BMP2K MAML1 KDM3B RELA HRNR ARL15 ARFIP1 RYR2 SNAP29 UBR5 PHACTR4 CDK5RAP2 ALB	1.54e-06	777	113	13	35844135
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	U2SURP HRNR CEP170 ALMS1 UBR5 ALB TRIM37	2.49e-06	184	113	7	32908313
Pubmed	Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.	CYP2A6 CYP2A13 ALB	2.77e-06	9	113	3	3917435
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	JCAD BMP2K MAML1 ELP6 RELA LYAR RIMBP3 ALMS1 UBR5 KIAA1217 PHACTR4 MAP4K4 TRIM37	4.27e-06	853	113	13	28718761
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MAML1 KDM3B SRGAP2 CEP170 TDRD3 SETD2 ARID1B ALMS1 ASB6 TPX2 CHD6 MAP4K4	4.98e-06	733	113	12	34672954
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	U2SURP KDM3B ARID1B TADA1 EPC1 TPX2	5.27e-06	134	113	6	25452129
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SCFD2 JCAD MAML1 KDM3B RYR2 RNF123 ARID1B CDK5RAP2 HFM1 CHD6 ATP2B3	7.79e-06	638	113	11	31182584
Pubmed	Homeodomain-interacting protein kinase HIPK4 regulates phosphorylation of manchette protein RIMBP3 during spermiogenesis.	HIPK4 RIMBP3	1.05e-05	2	113	2	35931115
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	1.05e-05	2	113	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	1.05e-05	2	113	2	21395539
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	1.05e-05	2	113	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	1.05e-05	2	113	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	1.05e-05	2	113	2	8395817
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	1.05e-05	2	113	2	25804444
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	1.05e-05	2	113	2	1520280
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	1.05e-05	2	113	2	23917075
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	1.05e-05	2	113	2	27902773
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	1.05e-05	2	113	2	30154104
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	1.05e-05	2	113	2	21418183
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	1.05e-05	2	113	2	19923441
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	1.05e-05	2	113	2	12499123
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	1.05e-05	2	113	2	22497566
Pubmed	Evidence for diverse roles of protein kinase-C in the inhibition of gene expression by insulin: the tyrosine aminotransferase, albumin, and phosphoenolpyruvate carboxykinase genes.	ALB PCK1	1.05e-05	2	113	2	7988415
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	1.05e-05	2	113	2	26363552
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	1.05e-05	2	113	2	2712571
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	1.05e-05	2	113	2	22696418
Pubmed	Two pools of IRE1α in cardiac and skeletal muscle cells.	ERN1 RYR2	1.05e-05	2	113	2	31051095
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	1.05e-05	2	113	2	30222954
Pubmed	An actin-WHAMM interaction linking SETD2 and autophagy.	WHAMM SETD2	1.05e-05	2	113	2	33036756
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	1.05e-05	2	113	2	7543189
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	1.05e-05	2	113	2	2372744
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	1.05e-05	2	113	2	21473878
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	1.05e-05	2	113	2	7581481
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	1.05e-05	2	113	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	1.05e-05	2	113	2	6309775
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	1.05e-05	2	113	2	22262919
Pubmed	Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5.	UBR5 PCK1	1.05e-05	2	113	2	30552140
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	1.05e-05	2	113	2	25635819
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	1.05e-05	2	113	2	566237
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	1.05e-05	2	113	2	8611142
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	1.05e-05	2	113	2	665441
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	1.05e-05	2	113	2	24104196
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PMS1 U2SURP KDM3B SRGAP2 ARFIP1 SNAP29 CEP170 TDRD3 SETD2 ALMS1 TKT KIAA1217 TPX2	1.12e-05	934	113	13	33916271
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.18e-05	14	113	3	17662146
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KDM3B ELP6 SNAP29 CEP170 SETD2 ARID1B ALMS1 PHACTR4 TPX2 MAP4K4	1.28e-05	549	113	10	38280479
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	MAGI1 JCAD SRGAP2 CEP170 ARID1B ALMS1 UBR5 MAP4K4 TRIM37	1.59e-05	446	113	9	24255178
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	JCAD ACO1 USP25 WHAMM NCKAP5 SRGAP2 EDIL3 RNF123 CCDC15 CHD6 EIF2AK1 MAP4K4 ST18 TRIM37 NR1D2	1.83e-05	1285	113	15	35914814
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	LYAR ALMS1 CCDC15 CDK5RAP2 TRIM37	2.05e-05	101	113	5	24613305
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ZNF180 TOPBP1 MAML1 RIMBP3 TDRD3 SETD2 ALMS1 UBR5 KIAA1217 TRIM37	2.31e-05	588	113	10	38580884
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	SCFD2 U2SURP TOPBP1 EDIL3 SNAP29 CEP170 FBXO38 ARID1B UBR5 TKT TPX2 CCDC15 CDK5RAP2 KIF4B	2.36e-05	1155	113	14	20360068
Pubmed	Murine inner cell mass-derived lineages depend on Sall4 function.	SALL3 SALL4 EDIL3	2.63e-05	18	113	3	17060609
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HIP1R SRGAP2 TRAPPC8 ARFIP1 TRIP10 AKAP11	3.10e-05	183	113	6	31932471
Pubmed	Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon.	ALB PCK1	3.13e-05	3	113	2	22013018
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	3.13e-05	3	113	2	18068688
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A13	3.13e-05	3	113	2	31645370
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	3.13e-05	3	113	2	3219345
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	3.13e-05	3	113	2	7849402
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	3.13e-05	3	113	2	20840855
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A13	3.13e-05	3	113	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A13	3.13e-05	3	113	2	8188299
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A13	3.13e-05	3	113	2	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A13	3.13e-05	3	113	2	2703500
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	3.13e-05	3	113	2	1973143
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A13	3.13e-05	3	113	2	22217847
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2A13	3.13e-05	3	113	2	21252290
Pubmed	Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.	CYP2A6 CYP2A13	3.13e-05	3	113	2	17466327
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A13	3.13e-05	3	113	2	22890016
Pubmed	A novel mouse model expressing human forms for complement receptors CR1 and CR2.	CR2 EDIL3	3.13e-05	3	113	2	32907542
Pubmed	Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation.	RELA PCK1	3.13e-05	3	113	2	21406501
Pubmed	The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins.	CEP170 CDK5RAP2	3.13e-05	3	113	2	29054927
Pubmed	Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.	CYP2A6 CYP2A13	3.13e-05	3	113	2	23073733
Pubmed	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.	CYP2A6 CYP2A13	3.13e-05	3	113	2	18602936
Pubmed	Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.	CARD9 TRIM62	3.13e-05	3	113	2	29073062
Pubmed	Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.	CARD9 IL23R	3.13e-05	3	113	2	24068945
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A13	3.13e-05	3	113	2	3346244
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A13	3.13e-05	3	113	2	2733794
Pubmed	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	CYP2A6 CYP2A13	3.13e-05	3	113	2	22552773
Pubmed	Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.	PMS1 HFM1	3.13e-05	3	113	2	28051769
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A13	3.13e-05	3	113	2	8484736
Pubmed	Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.	CYP2A6 CYP2A13	3.13e-05	3	113	2	11106424
Pubmed	Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.	CYP2A6 CYP2A13	3.13e-05	3	113	2	17303623
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A13	3.13e-05	3	113	2	1417950
Pubmed	Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.	CARD9 TRIM62	3.13e-05	3	113	2	27779380
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A13	3.13e-05	3	113	2	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A13	3.13e-05	3	113	2	32987105
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A13	3.13e-05	3	113	2	2765478
Pubmed	Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.	CYP2A6 CYP2A13	3.13e-05	3	113	2	25478736
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A13	3.13e-05	3	113	2	2415518
Pubmed	Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells.	RELA CDK5RAP2	3.13e-05	3	113	2	15184881
Pubmed	High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.	CYP2A6 CYP2A13	3.13e-05	3	113	2	32877213
Pubmed	Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.	CYP2A6 CYP2A13	3.13e-05	3	113	2	24191237
Pubmed	Structure of the human UBR5 E3 ubiquitin ligase.	UBR5 PCK1	3.13e-05	3	113	2	37040767
Pubmed	The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.	U2SURP TRIP10 ARID1B ALB	3.17e-05	55	113	4	35945219
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	PMS1 JCAD EED RBM12B HRNR SETD2 UBR5 TPX2 CHD6 ALB EIF2AK1	3.62e-05	754	113	11	35906200
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ACO1 PCDH12 KMT2E CSRP3 CEP170 ARID1B ALMS1 TKT CDK5RAP2	3.71e-05	497	113	9	23414517
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	U2SURP HIP1R HRNR ARFIP1 KIF4B ALB MAP4K4	4.15e-05	284	113	7	29459677
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	HRNR LYAR KIAA1217 TPX2 CCDC15	4.33e-05	118	113	5	30979931
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ROGDI ZNF180 CEP170 ALMS1 TRIM37	4.69e-05	120	113	5	31413325
Cytoband	22q11.21	SNAP29 RIMBP3 RIMBP3C RIMBP3B	1.70e-04	111	113	4	22q11.21
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	ZDHHC2 MAGI1 EED RBM12B USP25 NCKAP5 LYAR KMT2E TADA1 ALMS1 UBR5 TPX2 CHD6	2.80e-05	654	108	13	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	PMS1 RELCH SALL4 TEX14 TRAPPC8 LYAR TDRD1 ZC3H6 ALMS1 UBR5 HFM1 AKAP11 TRIM37 NR1D2	6.21e-05	810	108	14	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	RELCH TEX14 TDRD1 ZC3H6 AKAP11	7.36e-05	85	108	5	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k1_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	ZDHHC2 MAGI1 RELCH ZNF180 NCKAP5 LYAR SNAP29 TDRD3 SETD2 ALMS1 UBR5 EPC1 TPX2 CCDC15	8.16e-05	831	108	14	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
Drug	menthofuran	CYP2A6 CYP2A13 ALB	2.17e-06	6	110	3	ctd:C054487
Drug	heme As	CYP2A6 ACO1 SUOX ALB EIF2AK1 NR1D2	2.88e-06	82	110	6	CID006323354
Drug	Scarlet 3R	CYP2A6 SLC12A3 TRIM37	1.28e-05	10	110	3	CID005359780
Drug	propargyl ether	CYP2A6 CYP2A13	2.31e-05	2	110	2	ctd:C531209
Drug	Hempa	CYP2A6 CYP2A13	2.31e-05	2	110	2	ctd:D006492
Drug	nicotine imine	CYP2A6 CYP2A13	2.31e-05	2	110	2	ctd:C034629
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	2.31e-05	2	110	2	ctd:C008615
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	2.31e-05	2	110	2	ctd:C036676
Drug	Organoselenium Compounds	CYP2A6 CYP2A13 RELA MMP25 MAPK15	2.43e-05	71	110	5	ctd:D016566
Disease	Hepatic Insufficiency	RELA ALB	4.79e-04	9	109	2	C1306571
Disease	age at onset, multiple sclerosis	NCKAP5 BOD1L2	5.97e-04	10	109	2	EFO_0004847, MONDO_0005301
Disease	Epilepsy	ERN1 PCDH12 ARID1B ALB	7.28e-04	109	109	4	C0014544
Disease	Ankylosing spondylitis	CARD9 IL23R	7.28e-04	11	109	2	C0038013
Disease	lung adenocarcinoma (is_implicated_in)	SETD2 UBR5 MAP4K4	7.98e-04	49	109	3	DOID:3910 (is_implicated_in)
Disease	Adenocarcinoma of lung (disorder)	CYP2A13 ERN1 CSRP3 ALB EIF2AK1	1.03e-03	206	109	5	C0152013
Disease	Hepatomegaly	RELA ALB TRIM37	1.06e-03	54	109	3	C0019209
Disease	focal segmental glomerulosclerosis	CCDC7 ALMS1	1.57e-03	16	109	2	EFO_0004236
Disease	Diabetic Angiopathies	RELA ALB	1.57e-03	16	109	2	C0011875
Disease	Microangiopathy, Diabetic	RELA ALB	1.57e-03	16	109	2	C0025945
Disease	Ulcerative Colitis	RELA CARD9 IL23R	1.66e-03	63	109	3	C0009324
Disease	cognitive function measurement, self reported educational attainment	ZNF804A ARID1B ALMS1 SUOX TRIM37 NR1D2	2.08e-03	355	109	6	EFO_0004784, EFO_0008354
Disease	emphysema pattern measurement	JCAD CYP2A6	2.22e-03	19	109	2	EFO_0005850
Disease	autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis	SUOX CARD9 IL23R	2.24e-03	70	109	3	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ERN1 RELA ZNF804A SETD2	2.25e-03	148	109	4	C0279702
Disease	PR interval	MAGI1 NCKAP5 RYR2 CCDC7 HFM1 CHD6 TESC	2.46e-03	495	109	7	EFO_0004462
Disease	Nephritis, Tubulointerstitial	SLC12A3 ALB	2.71e-03	21	109	2	C0041349
Disease	Craniofacial Abnormalities	SALL3 SALL4 FGF3 TRIM37	2.72e-03	156	109	4	C0376634
Disease	Epilepsy, Cryptogenic	ERN1 ARID1B ALB	3.51e-03	82	109	3	C0086237
Disease	Awakening Epilepsy	ERN1 ARID1B ALB	3.51e-03	82	109	3	C0751111
Disease	Aura	ERN1 ARID1B ALB	3.51e-03	82	109	3	C0236018
Disease	Nephritis, Interstitial	SLC12A3 ALB	3.54e-03	24	109	2	C0027707
Disease	lung non-small cell carcinoma (is_marker_for)	SOX30 KDM3B UBR5 ALB	3.62e-03	169	109	4	DOID:3908 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TLPNHPNFRLKSSEN	TDRD1	46	Q9BXT4
NRFLNKQAPQTIHLP	ACO1	731	P21399
PQLPNEEKSLESHRA	CEP170	646	Q5SW79
VPRENHESEKPALNN	EPC1	811	Q9H2F5
FLQHKDDNPNLPRLV	ALB	126	P02768
PFLILANHQDKPAAR	ARL15	136	Q9NXU5
PDKEPNENLILRHQD	CCDC7	746	Q96M83
KVEHNQRTLDPNSPR	CYP2A6	251	P11509
LHNQPRLDPFFKQQA	ADAM2	371	Q99965
SQVVDPKLNHIFRPQ	BOD1L2	121	Q8IYS8
PFIRDNLLKTIPNHQ	COQ3	126	Q9NZJ6
QHREKPSIFHQQALP	ALMS1	1146	Q8TCU4
NSHFTEEQNPPRDLK	ALMS1	2751	Q8TCU4
PRDANTLPKIEQSQH	ARFIP1	281	P53367
PKEFKESLHNNPANR	CACNG3	296	O60359
ELPKSLQPSSQNHRF	AKAP11	1506	Q9UKA4
KPNHEDLNLIQQERP	ARID1B	731	Q8NFD5
NSQKLQLPENFDIHP	ASB6	336	Q9NWX5
QAQKEPHPLQFLREA	ELP6	96	Q0PNE2
REPPAELSLSHKNNQ	CCDC87	96	Q9NVE4
PQQEKNEKNLPQHRF	BMP2K	871	Q9NSY1
NEKNLPQHRFPAAGL	BMP2K	876	Q9NSY1
PKQPFAALHQEQVLR	CARD9	461	Q9H257
NSSIEFHPKPQQQRD	ATP2B3	6	Q16720
EIHNLQNKFRDLSPP	CDK5RAP2	1226	Q96SN8
QLDNFKHPQRDFRQP	RBM12B	536	Q8IXT5
PKLFDLRDQHADPQT	RASAL1	481	O95294
KFDAQGHLRAINPEN	PCK1	316	P35558
KPPRQRDALQQDLHA	RAB44	581	Q7Z6P3
RKDLLFQKSPQNHRP	RIMBP3B	1286	A6NNM3
RKDLLFQKSPQNHRP	RIMBP3C	1286	A6NJZ7
QLAALSPRQPHRQDK	IQCN	1101	Q9H0B3
LDINDHQPRFPKGEQ	PCDH12	126	Q9NPG4
PNRKLSPAFHQALLS	RELCH	481	Q9P260
EQEKQQFQRHLTRPP	MAML1	656	Q92585
HPAQAQLQSPEKLRD	MMP25	46	Q9NPA2
EQLLKHPFIRDQPNE	MAP4K4	281	O95819
LNQRFQKGSPDHELQ	MAGI1	116	Q96QZ7
NKTFHPVPNLRNLDL	LRRTM4	126	Q86VH4
QKELAHSQPAVQPRL	MFHAS1	396	Q9Y4C4
HLDRQRPDQPKASSQ	GPR179	1971	Q6PRD1
KENNFAPLPARHIRT	HIPK4	101	Q8NE63
HESPRAAKNVPRQNS	MAPK15	401	Q8TD08
FDDPRLRHFKLAQPQ	JCAD	426	Q9P266
RRQKQSPDNLEPSHV	FGF3	211	P11487
LPNNNHPDKFLQLDV	MINAR2	6	P59773
FHQILKNPNDPDTVD	HRNR	41	Q86YZ3
ENHENLFLQPPKLSR	KDM3B	616	Q7LBC6
LNTNNLLFKPPVESH	KMT2E	321	Q8IZD2
PEPFLAAHQDLNDKR	LRRC37B	111	Q96QE4
NAINELKFHPRDPNL	EED	191	O75530
KLNHRPSEPELNLNS	PHACTR4	551	Q8IZ21
AHGQLVRDLDFNPNK	EIPR1	226	Q53HC9
QLPHKREFSEENPAQ	INSL5	66	Q9Y5Q6
VIVHFQERKPQNLSP	HFM1	1361	A2PYH4
HEFSNPPNVRNKVRI	FBXO38	1031	Q6PIJ6
NFDNDTHRKNVIDPP	EDIL3	436	O43854
AQKPSVAPRQDHQLD	HIP1R	1041	O75146
PQHQEAAAARKFAPQ	GBX2	116	P52951
KLNPAANHRLRNDFP	GDE1	136	Q9NZC3
RQLLTKPQHQFVRPD	CR2	476	P20023
KVEHNQRTLDPNSPR	CYP2A13	251	Q16696
RDLKPRNIFLHGPDQ	EIF2AK1	441	Q9BQI3
LERFPNNLPKHRENV	ERN1	376	O75460
NNLPKHRENVIPADS	ERN1	381	O75460
PENKFNHTLAEPILR	CHD6	2421	Q8TD26
LSLLPDDQSQKHRSP	CENPJ	191	Q9HC77
LDSGNNPRLQKHPNF	IL23R	516	Q5VWK5
DKNPDNPRAAELFHQ	DNAJC17	41	Q9NVM6
VNKEQDQRPLHPVAN	LYAR	146	Q9NX58
SRQKHLPNDTLLSPD	KIF4B	1001	Q2VIQ3
EHLGLQFQQSPKPAR	CSRP3	86	P50461
PQQEKNEKSLPQHRF	BMP2KL	126	Q5H9B9
THRLKELPSQLFDPN	SALL3	1026	Q9BXA9
RHPQVKANPQLFAEF	SALL4	431	Q9UJQ4
LSKRLPQFLQVPSNH	RYR2	1251	Q92736
FVQDHRPQFLIENPK	PMS1	581	P54277
LAKEQLPQRQHPEAA	FAM181A	171	Q8N9Y4
EPFNNASPHLLKNLV	CFAP221	16	Q4G0U5
HEQTALPAQEQLRPK	NR1D2	216	Q14995
LHALQPNSTKNFRPA	ROGDI	206	Q9GZN7
RTQKSRDLSPPDNHL	TRIM37	446	O94972
VKDNNHLRHPPRNDT	TDRD3	311	Q9H7E2
PRQKEQPEHSEAFQA	TEX14	1036	Q8IWB6
RQKFDHRFQPQNPLS	TADA1	106	Q96BN2
NQLKIEPRNRHSPVA	NCKAP5	1596	O14513
RKDLLFQKSPQNHRP	RIMBP3	1286	Q9UFD9
QASHPNLRKLDDTDP	SNAP29	161	O95721
RPKEARHANVNPNED	KIAA1217	1351	Q5T5P2
HQNLGFRAPVKDDQP	WHAMM	671	Q8TF30
PQDVHLLNSARPDKR	SCFD2	181	Q8WU76
HRPALAKANPAANNA	SOX30	351	O94993
QIFNNKHSPRPEKRE	ST18	351	O60284
DSPHQNLSRPLLENK	U2SURP	66	O15042
SRDQHVLPKDQNILP	CCDC15	511	Q0P6D6
FSHLPPEQQRKRLQQ	TRIP10	391	Q15642
EQLHRRFKQLSGDQP	TESC	26	Q96BS2
VQQLHSLRNSFKLPP	PLEK2	111	Q9NYT0
QKNFDPRLHRLPNTE	ZC3H6	966	P61129
QDPRNPHNDRFVLSK	TKT	61	P29401
RKPLNFQNLPEHLDQ	RNF123	56	Q5XPI4
LHTQLLKDPEPAFQR	SRGAP2	996	O75044
AQDLPRNQKEHRNLP	USP25	206	Q9UHP3
LPDINQNPRAEHTKR	SLC12A3	896	P55017
KQIDNRLPELSHPQS	SETD2	1151	Q9BYW2
NPKISHNEQQRIPFE	ZNF180	311	Q9UJW8
EVKDGLPNNFRAHPL	TRAPPC8	286	Q9Y2L5
VRHPALKVNSQRPFN	SUOX	181	P51687
KNLENHQFPAKPLRE	ZDHHC2	316	Q9UIJ5
LHKAQPAERFFDPNQ	ZNF674	186	Q2M3X9
HPIFDNRAPNTAELK	RELA	181	Q04206
DIQNLEDSPFQKPLH	TOPBP1	1176	Q92547
NLHPQPLQDSPKRFD	TRIM62	321	Q9BVG3
KPPFDLNQLNHGSRL	ZFYVE26	2091	Q68DK2
ADQPHLLQPNARKED	UBR5	2051	O95071
RNKLSFHPNNLLPSE	ZNF804A	876	Q7Z570
PLAQQVEDFHKRTPN	TPX2	326	Q9ULW0