Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of nuclear lamina

LMNA LMNB1

5.83e-0521532GO:0160123
GeneOntologyCellularComponentcytoplasmic region

SPAST DNAH10 CNTRL IQSEC2 DNAH2 GRIK2 GCK CFAP54 DNAH17 RIMS2 CCDC40

8.06e-0536015511GO:0099568
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD8 RGPD1 MAD1L1

3.01e-04181553GO:0044615
GeneOntologyCellularComponentHULC complex

UBE2A UBE2B

3.25e-0441552GO:0033503
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

KRT5 SPAST DNAH10 FBF1 DNAH2 GCK TEK CHMP2A FAM83H KRT75 LMNA LMNB1 MAP1LC3C TTLL11 DNAH17 TMOD1 CEP295

3.77e-0489915517GO:0099513
GeneOntologyCellularComponentnuclear inclusion body

RAD18 RGPD8 RGPD1

4.15e-04201553GO:0042405
GeneOntologyCellularComponentXY body

RAD18 UBE2A UBE2B

6.35e-04231553GO:0001741
GeneOntologyCellularComponentspindle

SPAST FBF1 CNTRL CHMP2A SPDL1 YEATS2 FRY MAD1L1 CEP295 ATM MAPKBP1

7.98e-0447115511GO:0005819
GeneOntologyCellularComponentlamin filament

LMNA LMNB1

8.04e-0461552GO:0005638
GeneOntologyCellularComponentaxonemal dynein complex

DNAH10 DNAH2 DNAH17

8.16e-04251553GO:0005858
GeneOntologyCellularComponentspindle pole

SPAST FBF1 CNTRL SPDL1 FRY MAD1L1 MAPKBP1

8.61e-042051557GO:0000922
GeneOntologyCellularComponentintracellular protein-containing complex

UBR2 SUPT3H PDE3B RAD18 FBF1 CNTRL LARS1 PSMC3 FAM98B ITPR1 YEATS2 UBE2A UBE2B MEGF8 ANAPC1 SYVN1 ZSWIM4

9.03e-0497215517GO:0140535
GeneOntologyCellularComponentnuclear pore

RGPD8 RGPD1 CHMP2A MAD1L1 RGPD5

9.39e-041011555GO:0005643
GeneOntologyCellularComponentnuclear envelope

DPY19L3 SPAST RGPD8 SYNE1 RGPD1 CHMP2A ITPR1 PARP6 LMNA LMNB1 MAD1L1 RGPD5

9.80e-0456015512GO:0005635
GeneOntologyCellularComponentsupramolecular fiber

KRT5 SPAST DNAH10 SYNE1 FBF1 DNAH2 GCK TEK CHMP2A FAM83H KRT75 LMNA LMNB1 MAP1LC3C TTLL11 DNAH17 TMOD1 CEP295 RPL7

1.19e-03117915519GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

KRT5 SPAST DNAH10 SYNE1 FBF1 DNAH2 GCK TEK CHMP2A FAM83H KRT75 LMNA LMNB1 MAP1LC3C TTLL11 DNAH17 TMOD1 CEP295 RPL7

1.28e-03118715519GO:0099081
GeneOntologyCellularComponentmicrotubule organizing center

RAD18 RAPGEF6 SPAST FBF1 CNTRL UBR4 TSGA10 SPAG9 TEK SPDL1 FRY TTLL11 MAD1L1 CEP295 ATM CROCC

1.34e-0391915516GO:0005815
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD8 RGPD1

1.49e-0381552GO:1990723
GeneOntologyCellularComponentcentrosome

RAD18 RAPGEF6 SPAST FBF1 CNTRL UBR4 SPAG9 TEK SPDL1 FRY MAD1L1 CEP295 ATM CROCC

1.81e-0377015514GO:0005813
GeneOntologyCellularComponentubiquitin conjugating enzyme complex

UBE2A UBE2B

1.90e-0391552GO:0031371
GeneOntologyCellularComponentpostsynaptic density

TANC2 INSYN1 IQSEC2 GRIK2 ITPR1 LIN7B IQSEC1 PLEKHA5 PLCB4 RPL7

2.02e-0345115510GO:0014069
GeneOntologyCellularComponentinner dynein arm

DNAH10 DNAH2

2.36e-03101552GO:0036156
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD8 RGPD1

2.36e-03101552GO:0044614
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

SPAST DNAH10 CNTRL DNAH2 GRIK2 CFAP54 DNAH17 CCDC40

2.57e-033171558GO:0032838
MousePhenooligozoospermia

UBR2 RAPGEF6 DNAH10 DNAH2 SPAG9 CFAP54 LIPE UBE2B LMNA BRDT CBFA2T2 DNAH17 ICA1L ZMYM3

5.78e-0638412114MP:0002687
MousePhenoabnormal chromosome morphology

SPAST RGPD8 RGPD1 ORC1 UBE2B LMNA MAD1L1 ATM

1.34e-051261218MP:0003702
MousePhenoabnormal sperm number

UBR2 RAPGEF6 SPAST DNAH10 DNAH2 TSGA10 SPAG9 CFAP54 LIPE UBE2B LMNA BRDT CBFA2T2 DNAH17 ATM ICA1L ZMYM3

2.59e-0562412117MP:0002673
MousePhenoabnormal cell nucleus morphology

SPAST RGPD8 RGPD1 ORC1 UBE2B LMNA LMNB1 MAD1L1 ATM

3.11e-051841219MP:0003111
MousePhenodecreased male germ cell number

UBR2 RAD18 RAPGEF6 SPAST DNAH10 DNAH2 SPAG9 CFAP54 LIPE UBE2B LMNA BRDT CBFA2T2 DNAH17 ATM ICA1L ZMYM3

3.57e-0564012117MP:0004901
MousePhenodecreased germ cell number

UBR2 RAD18 RAPGEF6 SPAST DNAH10 DNAH2 SPAG9 CFAP54 LIPE UBE2B LMNA BRDT CBFA2T2 DNAH17 ATM ICA1L ZMYM3

8.59e-0568712117MP:0002209
MousePhenoabnormal chromosome number

SPAST RGPD8 RGPD1 ORC1 LMNA MAD1L1

9.93e-05861216MP:0004023
MousePhenodystrophic muscle

B4GAT1 DTNA SYNE1 LMNA

1.59e-04321214MP:0000752
MousePhenoaneuploidy

SPAST RGPD8 RGPD1 LMNA MAD1L1

1.81e-04611215MP:0004024
DomainChemokine_XCL1/XCL2

XCL2 XCL1

6.32e-0521492IPR008105
DomainKCC1

SLC12A6 SLC12A4

6.32e-0521492IPR000622
DomainGrip

RGPD8 RGPD1 RGPD5

7.83e-05111493SM00755
DomainGRIP

RGPD8 RGPD1 RGPD5

7.83e-05111493PF01465
DomainRan_BP1

RGPD8 RGPD1 RGPD5

1.04e-04121493PF00638
DomainRANBD1

RGPD8 RGPD1 RGPD5

1.04e-04121493PS50196
DomainGRIP_dom

RGPD8 RGPD1 RGPD5

1.04e-04121493IPR000237
DomainGRIP

RGPD8 RGPD1 RGPD5

1.04e-04121493PS50913
DomainRanBD

RGPD8 RGPD1 RGPD5

1.34e-04131493SM00160
DomainRan_bind_dom

RGPD8 RGPD1 RGPD5

1.34e-04131493IPR000156
DomainPDZ

RAPGEF6 APBA2 LIN7B PTPN4 RIMS2 PDZRN3 PDZD4

1.38e-041411497PF00595
DomainAAA

SPAST DNAH10 DNAH2 PSMC3 ATAD2 ABCA9 ORC1

1.58e-041441497SM00382
DomainAAA+_ATPase

SPAST DNAH10 DNAH2 PSMC3 ATAD2 ABCA9 ORC1

1.58e-041441497IPR003593
DomainPDZ

RAPGEF6 APBA2 LIN7B PTPN4 RIMS2 PDZRN3 PDZD4

1.87e-041481497SM00228
DomainIQSEC_PH

IQSEC2 IQSEC1

1.89e-0431492IPR033742
DomainIQ_SEC7_PH

IQSEC2 IQSEC1

1.89e-0431492PF16453
Domain-

RAPGEF6 APBA2 LIN7B PTPN4 RIMS2 PDZRN3 PDZD4

2.03e-0415014972.30.42.10
DomainPDZ

RAPGEF6 APBA2 LIN7B PTPN4 RIMS2 PDZRN3 PDZD4

2.11e-041511497PS50106
DomainPDZ

RAPGEF6 APBA2 LIN7B PTPN4 RIMS2 PDZRN3 PDZD4

2.20e-041521497IPR001478
DomainTRPM_tetra

TRPM6 TRPM1

3.75e-0441492PF16519
DomainTRPM_tetra

TRPM6 TRPM1

3.75e-0441492IPR032415
DomainKCL_cotranspt

SLC12A6 SLC12A4

3.75e-0441492IPR000076
DomainTPR-like_helical_dom

TANC2 RGPD8 ST7 GPS1 RGPD1 PRPF6 CFAP54 RGPD5

5.73e-042331498IPR011990
Domain-

LMNA LMNB1

6.22e-04514922.60.40.1260
DomainLamin_tail_dom

LMNA LMNB1

6.22e-0451492IPR001322
DomainLTD

LMNA LMNB1

6.22e-0451492PF00932
DomainPH_dom-like

ARHGAP42 RGPD8 IQSEC2 RGPD1 APBA2 PTPN4 IQSEC1 PLEKHA5 PLCB4 VASP RGPD5

6.30e-0442614911IPR011993
DomainAAA

SPAST PSMC3 ATAD2 ORC1

7.82e-04521494PF00004
DomainATPase_AAA_core

SPAST PSMC3 ATAD2 ORC1

9.03e-04541494IPR003959
Domain-

ARHGAP42 RGPD8 IQSEC2 RGPD1 APBA2 PTPN4 IQSEC1 PLEKHA5 PLCB4 VASP

1.19e-03391149102.30.29.30
DomainRab_bind

RGPD8 RGPD1

1.29e-0371492PF16704
DomainZnF_UBR1

UBR2 UBR4

1.29e-0371492SM00396
DomainSLC12A_fam

SLC12A6 SLC12A4

1.29e-0371492IPR004842
DomainGCC2_Rab_bind

RGPD8 RGPD1

1.29e-0371492IPR032023
DomainZF_UBR

UBR2 UBR4

1.29e-0371492PS51157
Domainzf-UBR

UBR2 UBR4

1.29e-0371492PF02207
DomainZnf_UBR

UBR2 UBR4

1.29e-0371492IPR003126
Domain-

TANC2 RGPD8 ST7 GPS1 RGPD1 PRPF6 CFAP54

1.38e-0320714971.25.40.10
DomainATPase_AAA_CS

SPAST PSMC3 ATAD2

1.56e-03291493IPR003960
DomainIntermediate_filament_CS

KRT5 KRT75 LMNA LMNB1

1.61e-03631494IPR018039
DomainSLC12_C

SLC12A6 SLC12A4

1.72e-0381492IPR018491
DomainDHC_N1

DNAH10 DNAH2

1.72e-0381492PF08385
DomainSLC12

SLC12A6 SLC12A4

1.72e-0381492PF03522
DomainDynein_heavy_dom-1

DNAH10 DNAH2

1.72e-0381492IPR013594
DomainTPR_REGION

TANC2 RGPD8 DNAH10 DNAH2 RGPD1 RGPD5

2.11e-031651496PS50293
DomainTPR

TANC2 RGPD8 DNAH10 DNAH2 RGPD1 RGPD5

2.11e-031651496PS50005
DomainAAA

SPAST PSMC3 ATAD2

2.48e-03341493PS00674
DomainIQ

IQSEC2 IQCF6 IQSEC1 CAMTA1

2.50e-03711494PF00612
DomainFilament

KRT5 KRT75 LMNA LMNB1

2.50e-03711494SM01391
DomainIF

KRT5 KRT75 LMNA LMNB1

2.63e-03721494PS00226
DomainCENP-B_N

TIGD1 TIGD6

2.73e-03101492PF04218
Domain-

RGPD8 RGPD1

2.73e-031014921.10.220.60
DomainFilament

KRT5 KRT75 LMNA LMNB1

2.76e-03731494PF00038
DomainIF

KRT5 KRT75 LMNA LMNB1

3.20e-03761494IPR001664
DomainFYVE_2

RPH3AL RIMS2

3.32e-03111492PF02318
DomainHTH_Psq

TIGD1 TIGD6

3.96e-03121492IPR007889
DomainHTH_PSQ

TIGD1 TIGD6

3.96e-03121492PS50960
DomainRABBD

RPH3AL RIMS2

3.96e-03121492PS50916
DomainCENPB

TIGD1 TIGD6

3.96e-03121492SM00674
DomainRab_BD

RPH3AL RIMS2

3.96e-03121492IPR010911
DomainDDE_1

TIGD1 TIGD6

3.96e-03121492PF03184
DomainDDE_SF_endonuclease_dom

TIGD1 TIGD6

3.96e-03121492IPR004875
DomainHTH_CENPB

TIGD1 TIGD6

4.65e-03131492PS51253
DomainHTH_Tnp_Tc5

TIGD1 TIGD6

4.65e-03131492PF03221
DomainHTH_CenpB_DNA-bd_dom

TIGD1 TIGD6

4.65e-03131492IPR006600
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH2

5.40e-03141492IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH2

5.40e-03141492IPR024743
DomainDynein_heavy_dom-2

DNAH10 DNAH2

5.40e-03141492IPR013602
DomainDHC_N2

DNAH10 DNAH2

5.40e-03141492PF08393
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH2

5.40e-03141492IPR011704
DomainMT

DNAH10 DNAH2

5.40e-03141492PF12777
DomainAAA_8

DNAH10 DNAH2

5.40e-03141492PF12780
DomainAAA_5

DNAH10 DNAH2

5.40e-03141492PF07728
DomainTPR_1

RGPD8 RGPD1 PRPF6 RGPD5

5.85e-03901494IPR001440
DomainTPR_1

RGPD8 RGPD1 PRPF6 RGPD5

5.85e-03901494PF00515
DomainIQ_motif_EF-hand-BS

IQSEC2 IQCF6 IQSEC1 CAMTA1

5.85e-03901494IPR000048
DomainDHC_fam

DNAH10 DNAH2

6.20e-03151492IPR026983
DomainDynein_heavy

DNAH10 DNAH2

6.20e-03151492PF03028
Domain-

IQSEC2 IQSEC1

6.20e-031514921.10.1000.11
DomainDynein_heavy_dom

DNAH10 DNAH2

6.20e-03151492IPR004273
DomainSec7

IQSEC2 IQSEC1

6.20e-03151492PF01369
DomainSec7_alpha_orthog

IQSEC2 IQSEC1

6.20e-03151492IPR023394
DomainIQ

IQSEC2 IQCF6 IQSEC1 CAMTA1

6.56e-03931494PS50096
DomainSEC7

IQSEC2 IQSEC1

7.05e-03161492PS50190
DomainSec7

IQSEC2 IQSEC1

7.05e-03161492SM00222
DomainSec7_dom

IQSEC2 IQSEC1

7.05e-03161492IPR000904
DomainTPR-contain_dom

TANC2 RGPD8 RGPD1 PRPF6 RGPD5

7.09e-031501495IPR013026
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

SPAST RGPD8 RGPD1 PSMC3 CHMP2A SPDL1 LMNA LMNB1 ANAPC1 MAD1L1

3.32e-0523412110MM14898
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SLC12A6 KRT5 RGPD8 DTNA SYNE1 FBF1 CNTRL UBR4 GPS1 DNAH2 RGPD1 PRPF6 FAM98B ESF1 PPP1CB KRT75 LMNA SLC12A4 LMNB1 GLUD1 SMARCA1 CEP295 ATM RIMS2 IMMT RGPD5

1.47e-0914421562635575683
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCAPD3 RAD18 PDE4C RAPGEF6 SPAG9 CHD7 ATAD2 TFAP4 ESF1 PPP1CB YEATS2 LMNA ANAPC1 CBFA2T2 MAD1L1 IQSEC1 ATM ZMYM3

1.42e-087741561815302935
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SLC12A6 UBR2 PDE3B RPH3AL DTNA ST7 ANXA6 UVSSA GRIK2 TFAP4 PPP1CB FBXO16 YEATS2 PTPN4 CBFA2T2 TTLL11 MAD1L1 PLCB4 TSC22D4 CAMTA1 CROCC ZSWIM4 CLEC16A ICA1L

5.66e-0814891562428611215
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RAD18 RGPD8 SYNE1 GPS1 RGPD1 SPAG9 PRPF6 NRIP3 GTF3C5 FAM83H ITPR1 PPP1CB ORC1 PHKA2 ACAD8 LMNB1 ANAPC1 MAD1L1 ATM ZMYM3 RGPD5

5.70e-0811551562120360068
Pubmed

The human RAD18 gene product interacts with HHR6A and HHR6B.

RAD18 UBE2A UBE2B

8.85e-083156310908344
Pubmed

Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells.

RAD18 UBE2A UBE2B

8.85e-083156312509447
Pubmed

UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4.

UBR4 UBE2A UBE2B

8.85e-083156338182926
Pubmed

Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.

RAD18 UBE2A UBE2B

8.85e-083156310884424
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

RAD18 CCDC137 MRS2 DTNA GPS1 LARS1 APBA2 PSMC3 MRPS16 FAM98B MCM10 GTF3C5 MRPL17 LMNA LMNB1 ANAPC1 BTBD7 TTLL11 SMARCA1 TMOD1 IMMT RPL7

1.47e-0713351562229229926
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

LRSAM1 UBR4 LARS1 PSMC3 PRPF6 CHD7 MCM10 ATAD2 GTF3C5 ESF1 FAM83H PPP1CB BUD23 ORC1 LMNA LMNB1 SMARCA1 IQSEC1 PLEKHA5 IMMT RPL7 ZMYM3

1.85e-0713531562229467282
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ANXA6 UBR4 PSMC3 SPAG9 PRPF6 CHD7 ATAD2 ESF1 PPP1CB LMNA ANAPC1 ATM IMMT RPL7 ZMYM3

2.85e-076531561522586326
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBR2 SYNE1 YEATS2 MEGF8 ACOT11 BTBD7 CAMTA1 MAPKBP1 SYVN1 CROCC CLEC16A ZMYM3

3.47e-074071561212693553
Pubmed

ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.

RAD18 UBE2A UBE2B

3.53e-074156312776193
Pubmed

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.

UBR2 RAD18 UBR4 UBE2A UBE2B

3.65e-0733156525582440
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RAPGEF6 RGPD8 UBR4 RGPD1 ZDBF2 CHD7 GTF3C5 SPDL1 YEATS2 ANAPC1 PLEKHA5 ZMYM3

4.60e-074181561234709266
Pubmed

Human transcription factor protein interaction networks.

SOX6 SUPT3H RAD18 DNAH10 MRS2 DTNA UBR4 LARS1 RGPD1 PSMC3 MRPS16 SPAG9 CHD7 TFAP4 BUD23 MRPL17 YEATS2 RBM12 GLUD1 SMARCA1 IMMT ZMYM3

4.66e-0714291562235140242
Pubmed

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination.

RAD18 UBE2A UBE2B

8.79e-075156315359278
Pubmed

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.

RAD18 UBE2A UBE2B

8.79e-075156318363965
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

TANC2 NCAPD3 ANXA6 FBF1 UBR4 DNAH2 RGPD1 ZDBF2 CHD7 GTF3C5 ESF1 YEATS2 MEGF8 CEP295

1.24e-066381561431182584
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TRPM6 NCAPD3 DNAH10 SYNE1 ANXA6 UBR4 LARS1 PSMC3 PRPF6 ATAD2 GTF3C5 ESF1 SPDL1 LMNA LMNB1 ANAPC1 GLUD1 SMARCA1 ATM IMMT RPL7

1.74e-0614251562130948266
Pubmed

Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.

RAD18 UBE2A UBE2B

1.75e-066156315383616
Pubmed

NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.

RAD18 UBE2A UBE2B

1.75e-066156321884979
Pubmed

Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.

RAD18 UBE2A UBE2B

1.75e-066156321858012
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

TANC2 SLC12A6 KRT5 SYNE1 IQSEC2 LARS1 PSMC3 FAM98B NDUFB7 JMY PPP1CB LMNA GLUD1 IQSEC1 SLC17A7 TMOD1 PLEKHA5 TSC22D4 CROCC IMMT RPL7

1.86e-0614311562137142655
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

TANC2 DTNA SPAG9 ITPR1 PARP6 CAMTA1 RIMS2

1.92e-06128156730995482
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD8 RGPD1 RGPD5

3.06e-067156315710750
Pubmed

Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.

UBR2 UBE2A UBE2B

3.06e-067156321816346
Pubmed

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.

RAD18 UBE2A UBE2B

3.06e-067156315657431
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

DTNA LRSAM1 PSMC3 MEGF8 CBFA2T2 MAD1L1 PLEKHA5 TSC22D4 MAPKBP1 SYVN1 IMMT ITPRIPL1 PDZD4

3.99e-066081561316713569
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

NCAPD3 RAD18 CHMP2A ESF1 PHKA2 LMNA ANAPC1 MAD1L1

5.22e-06210156816565220
Pubmed

Defining the membrane proteome of NK cells.

KRT5 NCAPD3 PDE3B ANXA6 CNTRL UBR4 PSMC3 PRPF6 CHMP2A ITPR1 CSGALNACT2 LMNB1 IQSEC1 PLEKHA5 SYVN1 IMMT RPL7 ITPRIPL1

5.54e-0611681561819946888
Pubmed

Protein phosphatase 1γ isoforms linked interactions in the brain.

B4GAT1 INSYN1 ZDBF2 ACAD8 RPL7

5.91e-0657156523080069
Pubmed

Autophagy mediates degradation of nuclear lamina.

LMNA LMNB1 MAP1LC3C

7.29e-069156326524528
Pubmed

Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.

SYNE1 LMNA LMNB1

1.04e-0510156328533284
Pubmed

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex.

MYF5 PDE3B LIPE

1.04e-0510156324196706
Pubmed

Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain.

ITPR1 SLC17A7 PLCB4

1.04e-0510156315579147
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

TANC2 RGPD8 RGPD1 LMNA LMNB1 IQSEC1 RIMS2 RPL7

1.05e-05231156816452087
Pubmed

Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.

XCL2 XCL1

2.00e-05215628849694
Pubmed

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

SLC12A6 SLC12A4

2.00e-052156234031912
Pubmed

Breast carcinoma with brain metastases: clinical analysis and immunoprofile on tissue microarrays.

KRT5 KRT75

2.00e-052156221427063
Pubmed

Effects of lamin A/C, lamin B1, and viral US3 kinase activity on viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane.

LMNA LMNB1

2.00e-052156218524819
Pubmed

The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.

UBE2A UBE2B

2.00e-052156215169909
Pubmed

Cell nuclei spin in the absence of lamin b1.

LMNA LMNB1

2.00e-052156217488709
Pubmed

Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy.

LMNA LMNB1

2.00e-052156211792809
Pubmed

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.

UBE2A UBE2B

2.00e-052156212556476
Pubmed

The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.

UVSSA ATM

2.00e-052156235254895
Pubmed

Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes.

LMNA LMNB1

2.00e-05215629367621
Pubmed

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.

UBE2A UBE2B

2.00e-05215621717990
Pubmed

Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31.

UBE2A UBE2B

2.00e-05215621559696
Pubmed

The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids.

UBR2 UBE2B

2.00e-052156220537150
Pubmed

Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells.

RAD18 UBE2B

2.00e-052156222547805
Pubmed

Decreased lamin A and B1 expression results in nuclear enlargement in serous ovarian carcinoma, whereas lamin A-expressing tumor cells metastasize to lymph nodes.

LMNA LMNB1

2.00e-052156237229920
Pubmed

Symmetry and asymmetry of the RING-RING dimer of Rad18.

RAD18 UBE2B

2.00e-052156221549715
Pubmed

Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C.

SYNE1 LMNA

2.00e-052156211801724
Pubmed

Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity.

XCL2 XCL1

2.00e-05215629834111
Pubmed

The NMR structure of the class I human ubiquitin-conjugating enzyme 2b.

UBE2A UBE2B

2.00e-052156211885984
Pubmed

T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production.

XCL2 XCL1

2.00e-052156222528127
Pubmed

Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.

XCL2 XCL1

2.00e-052156225497737
Pubmed

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.

XCL2 XCL1

2.00e-052156219097989
Pubmed

RAD18 and associated proteins are immobilized in nuclear foci in human cells entering S-phase with ultraviolet light-induced damage.

RAD18 UBE2A

2.00e-052156218926833
Pubmed

Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.

RIPK1 LMNA

2.00e-052156238538837
Pubmed

Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.

SLC12A6 SLC12A4

2.00e-052156231835175
Pubmed

Molecular characterization of epithelioid haemangioendotheliomas identifies novel WWTR1-CAMTA1 fusion variants.

WWTR1 CAMTA1

2.00e-052156225817592
Pubmed

The differential expression of lamin epitopes during mouse spermatogenesis.

LMNA LMNB1

2.00e-05215627680212
Pubmed

Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization.

UBE2A UBE2B

2.00e-052156231683936
Pubmed

Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo.

XCL2 XCL1

2.00e-05215629029087
Pubmed

Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.

LMNA LMNB1

2.00e-052156225343989
Pubmed

The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation.

XCL2 XCL1

2.00e-052156231413355
Pubmed

The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A.

LMNA LMNB1

2.00e-052156225807068
Pubmed

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.

LMNA LMNB1

2.00e-052156219141474
Pubmed

Thoracic epithelioid malignant vascular tumors: a clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions.

WWTR1 CAMTA1

2.00e-052156225353289
Pubmed

RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.

UBE2A UBE2B

2.00e-052156228806395
Pubmed

Beta-strand-mediated dimeric formation of the Ig-like domains of human lamin A/C and B1.

LMNA LMNB1

2.00e-052156233706103
Pubmed

Loss of RAD6B induces degeneration of the cochlea in mice.

UBR2 UBE2B

2.00e-052156232868078
Pubmed

Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination.

RAD18 UBE2A

2.00e-052156215509568
Pubmed

Adenovirus-mediated intratumoral lymphotactin gene transfer potentiates the antibody-targeted superantigen therapy of cancer.

XCL2 XCL1

2.00e-052156212226740
Pubmed

Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins.

LMNA LMNB1

2.00e-05215623453101
Pubmed

Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy.

SYNE1 LMNA

2.00e-052156221156181
Pubmed

Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice.

XCL2 XCL1

2.00e-052156224778093
Pubmed

Protein-protein interactions between human nuclear lamins expressed in yeast.

LMNA LMNB1

2.00e-05215627628545
Pubmed

Molecular cloning and functional characterization of human lymphotactin.

XCL2 XCL1

2.00e-05215627602097
Pubmed

A direct role of SRY and SOX proteins in pre-mRNA splicing.

SOX6 SRY

2.00e-052156211818535
Pubmed

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.

SLC12A6 SLC12A4

2.00e-052156217510708
Pubmed

Monomeric solution structure of the prototypical 'C' chemokine lymphotactin.

XCL2 XCL1

2.00e-052156211601972
Pubmed

ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint.

MAD1L1 ATM

2.00e-052156224728176
Pubmed

Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins.

LMNA LMNB1

2.00e-052156224523288
Pubmed

Molecular cloning of a novel C or gamma type chemokine, SCM-1.

XCL2 XCL1

2.00e-05215627875320
Pubmed

In-vitro activation of cytotoxic T lymphocytes by fusion of mouse hepatocellular carcinoma cells and lymphotactin gene-modified dendritic cells.

XCL2 XCL1

2.00e-052156217990361
Pubmed

Monoclonality of multifocal epithelioid hemangioendothelioma of the liver by analysis of WWTR1-CAMTA1 breakpoints.

WWTR1 CAMTA1

2.00e-052156222429593
Pubmed

The Bfp60 surface adhesin is an extracellular matrix and plasminogen protein interacting in Bacteroides fragilis.

LMNA PLG

2.00e-052156223850366
Pubmed

DCM associated LMNA mutations cause distortions in lamina structure and assembly.

LMNA LMNB1

2.00e-052156228844980
Pubmed

Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia.

XCL2 XCL1

2.00e-05215628757601
Pubmed

Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins.

LMNA LMNB1

2.00e-052156233570570
Pubmed

RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis.

TFEB RIPK1

2.00e-052156225908842
Pubmed

A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells.

XCL2 XCL1

2.00e-052156230542351
Pubmed

The role of cytokeratin 5/6 as an adjunct diagnostic tool in breast core needle biopsies.

KRT5 KRT75

2.00e-052156218499686
Pubmed

A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites.

WWTR1 CAMTA1

2.00e-052156221584898
Pubmed

Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein.

XCL2 XCL1

2.00e-052156214734774
Pubmed

β-Amyloid induces nuclear protease-mediated lamin fragmentation independent of caspase activation.

LMNA LMNB1

2.00e-052156226876308
Pubmed

Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin.

XCL2 XCL1

2.00e-052156211181058
Cytoband17q25.3

CCDC137 GPS1 DNAH17 CCDC40

4.05e-04101156417q25.3
Cytoband6q16.3

GRIK2 HACE1

4.07e-04915626q16.3
GeneFamilyPDZ domain containing

RAPGEF6 APBA2 LIN7B PTPN4 RIMS2 PDZRN3 PDZD4

3.76e-0515210971220
GeneFamilyLamins

LMNA LMNB1

1.08e-0431092612
GeneFamilyDyneins, axonemal

DNAH10 DNAH2 DNAH17

1.36e-04171093536
GeneFamilyAAA ATPases

SPAST PSMC3 ATAD2 ORC1

2.92e-04531094413
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR2 UBR4

7.42e-0471092785
GeneFamilyHelix-turn-helix CENPB type domain containing

TIGD1 TIGD6

2.69e-03131092533
CoexpressionAtlasfacebase_RNAseq_e10.5_NeuroEpith_central_2500_K4

SOX6 RAD18 SPAST DTNA CNTRL TSGA10 APLP1 GRIK2 ZDBF2 SPAG9 CHD7 FAM98B ESF1 SPDL1 LIN7B FBXO16 ORC1 PTPN4 CFAP54 RBM12 CEP295 PLCB4 ATM CAMTA1 CCDC40

1.25e-05137015125facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
ToppCellASK440-Immune-NK_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

SYNE1 ANXA6 APBA2 PTPN4 XCL2 XCL1 ITPRIPL1 PDZD4

3.16e-071861568ce8e63057a99afa0a9cbf27ae7f9a70c0e972b6d
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAH2 TSGA10 CFAP54 PLEKHA5 CROCC ICA1L CCDC40

4.18e-071931568ea345d34440b25f65358a53dc72831998d1c3620
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

TANC2 PDE3B DTNA SLC24A3 CSGALNACT2 PLEKHA5 PLCB4 PDZRN3

4.88e-071971568f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellControl-NK|World / Disease group and Cell class

TANC2 IQSEC2 ACOT11 XCL2 XCL1 PDZD4 RGPD5

7.41e-071431567fe08adc9472dfd4242497d6c614d0490713261da
ToppCell367C-Lymphocytic-ILC-ILC-2|367C / Donor, Lineage, Cell class and subclass (all cells)

CNTRL APBA2 PTPN4 XCL2 XCL1 CLEC16A ITPRIPL1

2.65e-0617315670451450605521fecb27a958628870d268adfb023
ToppCellHealthy_donor-NK_CD56bright|World / disease group, cell group and cell class (v2)

SYNE1 APBA2 PTPN4 LMNA XCL2 ATM XCL1

4.58e-0618815678ee359199c61c3b5b498ac35148390db5cc1a836
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D|343B / Donor, Lineage, Cell class and subclass (all cells)

ANXA6 APBA2 PTPN4 XCL2 ATM XCL1 PDZD4

5.08e-0619115672bd4ba4aaa0f4885079516156b409df527ab22f4
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3B RPH3AL APLP1 ZDBF2 ITPR1 SMARCA1 RIMS2

5.08e-061911567657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 B4GALT6 PTPN4 LMNB1 XCL2 XCL1 VASP

5.44e-061931567b53ffef20f918b7d1e9d3924562691d13245e2dd
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 SYNE1 DNAH2 TSGA10 CFAP54 CFAP99 CCDC40

5.63e-0619415674a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellCOVID-19_Severe-CD8+_Tem|COVID-19_Severe / disease group, cell group and cell class

SYNE1 ANXA6 APBA2 PTPN4 XCL2 ATM PDZD4

6.02e-0619615671bc1ec3351319c5d2daa0808cf161a7327e1758e
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 ANXA6 OR4D1 PTPN4 FRY ATM PDZD4

6.43e-06198156788bb764b21ca50e56f6c536a2d61d35afd8c3f36
ToppCellSevere_COVID-19-T/NK-CD8+_T|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PDE3B SYNE1 ANXA6 APBA2 PTPN4 XCL2 XCL1

6.43e-061981567584f0dc6f22bb13956a5f6950698599e382907e9
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANXA6 MCM10 ATAD2 ORC1 LMNB1 XCL2 XCL1

6.43e-0619815674909a97c62702704a0327b9a2cd73f048c8afeb6
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 APBA2 PTPN4 XCL2 ATM XCL1 PDZD4

6.43e-06198156758d805e827299292750b09c6283fdbe406b75f79
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH10 SYNE1 CNTRL DNAH2 TSGA10 CFAP54 CCDC40

6.43e-061981567ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PDE3B SYNE1 ANXA6 APBA2 PTPN4 XCL2 XCL1

6.43e-0619815672eb80255bacddbf778b1c9eec09f74b4cdb09b36
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3B SYNE1 ANXA6 APBA2 PTPN4 XCL2 XCL1

6.43e-061981567ec99da4e269c4cd982a395cdac0e4487ab14ec39
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3B SYNE1 ANXA6 APBA2 PTPN4 XCL2 XCL1

6.43e-06198156706fdf8554148d11c0a946a7fd200edd9fa7e1965
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYNE1 TEK ABCA9 FRY IQSEC1 PLCB4 PDZRN3

6.87e-062001567032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX6 SLC24A3 GRIK2 TEK FRY PLCB4 RIMS2

6.87e-062001567f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX6 SLC24A3 GRIK2 TEK FRY PLCB4 RIMS2

6.87e-062001567cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYNE1 TEK ABCA9 FRY IQSEC1 PLCB4 PDZRN3

6.87e-06200156768fce28690246895fd33354b30960ebcc31aa4cc
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX6 SLC24A3 GRIK2 TEK FRY PLCB4 RIMS2

6.87e-062001567c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYNE1 TEK ABCA9 FRY IQSEC1 PLCB4 PDZRN3

6.87e-062001567376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX6 SLC24A3 GRIK2 TEK FRY PLCB4 RIMS2

6.87e-0620015674fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYNE1 TEK ABCA9 FRY IQSEC1 PLCB4 PDZRN3

6.87e-0620015677fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-NK|Int-URO / Disease, condition lineage and cell class

SYNE1 ANXA6 APBA2 PTPN4 XCL2 ATM XCL1

6.87e-0620015673ae0f3dc4f6c9e0315155de80967134b2c1b3364
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX6 SLC24A3 GRIK2 TEK FRY PLCB4 RIMS2

6.87e-062001567310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYNE1 TEK ABCA9 FRY IQSEC1 PLCB4 PDZRN3

6.87e-062001567878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYNE1 TEK ABCA9 FRY IQSEC1 PLCB4 PDZRN3

6.87e-0620015677136936d05ab344a560cf159684c881063b5430d
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ARHGAP42 SYNE1 ANXA6 ITPR1 LURAP1L LMNA TMOD1

6.87e-06200156777631c471cc5d453a749784f838cfa6408caf09b
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX6 SLC24A3 GRIK2 TEK FRY PLCB4 RIMS2

6.87e-062001567961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell356C-Myeloid-Mast_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 SLC24A3 CFAP54 LMNA TMOD1 ZSWIM4

1.39e-0514815661668d8a9e680da335362744f36b05446c499347e
ToppCell356C-Myeloid-Mast_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 SLC24A3 CFAP54 LMNA TMOD1 ZSWIM4

1.39e-05148156618511ba10765eda937c5a710626361f7e6b9b321
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRSAM1 SLC26A9 SLC24A3 GRIK2 PLA2G4E PDZD4

1.50e-05150156647ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV5/7_gdT|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SUPT3H PDE3B RAPGEF6 PTPN4 XCL2 XCL1

2.74e-05167156618e336faa2d2429ab49d1c6ae9bbf9923d74aa8d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 MCM10 TEK ATAD2 ORC1 LMNB1

2.74e-051671566bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

PDE3B RAPGEF6 SYNE1 JMY LMNA ATM

3.13e-0517115662e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

B4GAT1 PARP6 PHKA2 ZSWIM4 CLEC16A CCDC40

3.34e-051731566090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRPM6 TFEB MYF5 ST7 FAM83H ATM

3.56e-051751566711ace94fa9a763c6ae48171a690953f25deebe4
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_bright-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYNE1 ANXA6 PTPN4 XCL2 ATM XCL1

4.30e-0518115669c4f9abb9335da2b07644bca8faff1baa1bb9f5b
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NCAPD3 ATAD2 ORC1 LMNB1 XCL2 XCL1

4.30e-051811566e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPM6 SOX6 ARHGAP42 GRIK2 BRDT PLCB4

4.57e-051831566351d575339038bd4a66f408da518c567444208e8
ToppCellCOVID-19_Convalescent-Lymphoid_T/NK-CD8+_T_naive|COVID-19_Convalescent / Disease group, lineage and cell class

PDE3B RAPGEF6 APBA2 ATM ICA1L RPL7

4.71e-0518415660299cd30a3ea8e861a9d529043c204048ae21d29
ToppCellILEUM-inflamed-(1)_T_cell-(1)_CD8_Trm|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PDE3B APBA2 XCL2 ZSWIM4 XCL1 RGPD5

4.71e-051841566cef3ee2a4a0af961aa3b4c92150d423e841ae8c1
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3B RAPGEF6 APBA2 ATM ICA1L RPL7

4.86e-051851566863a3d44c1f115942d7a2a2b63a92fe5fc768814
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B APBA2 ATAD2 JMY ATM RGPD5

4.86e-051851566847257d232b9993cad50c814fd4ffeef52385295
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH2 TSGA10 ZDBF2 CFAP54 RBM12

4.86e-05185156605bc89a566b0db90ae06506e067190a4739a0974
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3B RAPGEF6 APBA2 ATM ICA1L RPL7

4.86e-05185156627dbfcd40ec832d5cf757331d8af3b5176ae90fb
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ARHGAP42 SLC24A3 CHD7 TEK OLIG1

4.86e-0518515662e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ARHGAP42 SLC24A3 CHD7 TEK OLIG1

4.86e-0518515667aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

DNAH10 DNAH2 TSGA10 CFAP54 CFAP99 CCDC40

4.86e-05185156630f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PDE3B RAPGEF6 APBA2 ATM ICA1L RPL7

4.86e-0518515661c23891e4d75f99296d1304af7a9d6c3cb28d04c
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3B RAPGEF6 APBA2 ATM ICA1L RPL7

4.86e-051851566ca8e921a6b45cd39474b9f86c95e7be023585c5d
ToppCellNS-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KRT5 WWTR1 ESF1 LMNA SLC17A7 PLEKHA5

5.00e-051861566c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3B RAPGEF6 ANXA6 PTPN4 TRPM1 XCL1

5.00e-0518615664dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3B RAPGEF6 ANXA6 PTPN4 TRPM1 XCL1

5.00e-051861566e23e1246914e230369a716d0d666b98383bf8512
ToppCellCOVID-19_Mild-Neu_4|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

TANC2 RAD18 CNTRL LARS1 ATAD2 PLEKHA5

5.16e-051871566714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ARHGAP42 SLC24A3 CHD7 TEK OLIG1

5.16e-051871566daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCellCerebellum-Neuronal|Cerebellum / BrainAtlas - Mouse McCarroll V32

INSYN1 ZDBF2 NRIP3 LIN7B TTLL11 PDZD4

5.16e-05187156661b9d6eb131a674598aa8409d7fa909c8765442d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 PDE3B GRIK2 MCM10 ATAD2 LMNB1

5.16e-051871566057569c9437219ecc396aa6e673b1178a2273837
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ARHGAP42 SLC24A3 CHD7 TEK OLIG1

5.16e-0518715665b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

DTNA SLC24A3 ITPR1 FRY PLCB4 PDZRN3

5.31e-05188156634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellNS-critical-d_0-4-Lymphoid-CTL|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SUPT3H PDE3B PTPN4 XCL2 ATM XCL1

5.47e-051891566fb7572fb4c7c43886d57a025decad076f32a14c4
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CytoT_GZMK+-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYNE1 ANXA6 PTPN4 XCL2 ATM XCL1

5.47e-051891566f1129eb122bbc051457c5545f1a267beb988b0f2
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CytoT_GZMK+|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYNE1 ANXA6 PTPN4 XCL2 ATM XCL1

5.47e-0518915660b012ee301419fa9ccc387c3ff66c2344b349a97
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE3B SYNE1 ANXA6 APBA2 PTPN4 ATM

5.63e-051901566d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellSevere-Lymphoid-T-NK|Severe / Condition, Lineage, Cell class and cell subclass

SUPT3H APBA2 ATAD2 PTPN4 XCL2 XCL1

5.63e-05190156660642de433f84fa2cecd796c3a1a4aab9219d3db
ToppCellASK428-Immune-NK_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

APBA2 PTPN4 XCL2 TSC22D4 XCL1 PDZD4

5.63e-051901566d649f7e17c4227787465dfc02037f791ff85378b
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

NCAPD3 RAD18 ATAD2 LMNB1 MAD1L1 CEP295

5.63e-051901566d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellfacs-Pancreas-Endocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3B APLP1 ZDBF2 ITPR1 SMARCA1 RIMS2

5.80e-051911566b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

NCAPD3 MCM10 ATAD2 ORC1 LMNB1 ITPRIPL1

5.80e-051911566bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellcritical-Lymphoid-CTL|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SUPT3H PDE3B APBA2 PTPN4 XCL2 XCL1

5.97e-0519215668c83050c1578d43ca0398ff920f30ea63f092a83
ToppCell343B-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PDE3B UBE2B RBM12 SLC12A4 CEP295 ICA1L

5.97e-051921566445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

PDE3B SYNE1 PTPN4 XCL2 ATM XCL1

6.14e-051931566995781d87a919c0380750878bafe584342bb83ad
ToppCellControl-Lymphocyte-T_NK|Control / Disease, Lineage and Cell Type

SUPT3H SYNE1 PTPN4 XCL2 ATM XCL1

6.14e-051931566eb8b8f6e52fd140fbacf3d6776458c6fc355e120
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH10 SYNE1 DNAH2 TSGA10 CFAP54 CCDC40

6.14e-051931566ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellInt-URO-Lymphocyte-T_NK-NK|Int-URO / Disease, Lineage and Cell Type

SYNE1 APBA2 PTPN4 XCL2 ATM XCL1

6.14e-0519315665c7942f630fc69374df34ee3602ad973b6ced17a
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 MCM10 PTPN4 XCL2 XCL1 PDZD4

6.32e-0519415668bfd7c5be518b81b17913139bcb3ebea01f48dd5
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TANC2 RPH3AL ST7 SYNE1 SLC26A9 WWTR1

6.32e-05194156697534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 MCM10 PTPN4 XCL2 XCL1 PDZD4

6.32e-051941566f0707601883b234ed477c7704ca9a88efaefc3fd
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

ARHGAP42 DNAH10 SYNE1 CFAP54 PLEKHA5 PLCB4

6.50e-051951566fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYNE1 ANXA6 PTPN4 XCL2 ATM XCL1

6.50e-051951566609732e83ab7fc3ba7dace66f5a17e46557fd6d1
ToppCellproximal-Hematologic-Natural_Killer_T-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TIGD1 APBA2 ZDBF2 TFAP4 XCL2 XCL1

6.50e-0519515664d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCell343B-Lymphocytic-NK_cells|343B / Donor, Lineage, Cell class and subclass (all cells)

ANXA6 APBA2 PTPN4 XCL2 ATM XCL1

6.50e-05195156633a460624a65ba033452c74d143089e0bfac8f3d
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

NCAPD3 PDE3B MCM10 ATAD2 LMNB1 ITPRIPL1

6.50e-0519515667e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

ARHGAP42 DNAH10 SYNE1 CFAP54 PLEKHA5 PLCB4

6.50e-051951566eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellfacs-Skin-nan-18m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LETM2 INSYN1 ANXA6 LMNA IQSEC1 PDZRN3

6.50e-051951566ba7cb80deb872c9184769f0dd57855c3c6a432bf
ToppCellproximal-3-Hematologic-Natural_Killer_T|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TIGD1 APBA2 ZDBF2 TFAP4 XCL2 XCL1

6.50e-05195156693093545bb23d2619ace029a52cffa1f673a0c2a
ToppCellproximal-Hematologic-Natural_Killer_T|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TIGD1 APBA2 ZDBF2 TFAP4 XCL2 XCL1

6.50e-0519515663944e4800f5d904d4efa401ce8913ec0e0781211
ToppCellLAM-Lymphoid-NK|LAM / Condition, Lineage and Cell class

ANXA6 APBA2 PTPN4 XCL2 ATM XCL1

6.50e-051951566229374c72acef32b0e915379bdf3c82f351940e2
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 APBA2 PTPN4 XCL2 ATM PDZD4

6.69e-0519615660f3c7fd450aaa1f866b8558692534c0ea2a34e75
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SYNE1 APBA2 PTPN4 XCL2 ATM PDZD4

6.69e-0519615664e1f8828413896ab8a4ec92a89d6789e8e37e05a
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC2 MYF5 ANXA6 ZDBF2 LMNA RPL7

6.69e-05196156697ac47daf5bb07fa5dda3976e1ae402750f959b5
ToppCellsevere_influenza-CD8+_Tem|World / disease group, cell group and cell class (v2)

SYNE1 ANXA6 APBA2 PTPN4 XCL2 PDZD4

6.69e-05196156640fb254abcab2e65affc5d6037e71893a031d264
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B SYNE1 APBA2 PTPN4 ATM RGPD5

6.69e-051961566c4e7133c609bcbc48c4947ea0aa1a7d9d7251b04
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCAPD3 MCM10 ATAD2 MRPL17 ORC1 LMNB1

6.69e-051961566de70cc301a8cbaedb0a5ea4a6442dcdaa477822d
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SUPT3H SYNE1 APBA2 PTPN4 XCL2 XCL1

6.88e-05197156648311c7d85ffabf59fd1685c31c18b3e84a145b5
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SOX6 DTNA FRY TMOD1 PLCB4 PDZRN3

6.88e-051971566bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
DrugPhenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

TANC2 SPAST B4GAT1 DTNA ST7 GTF3C5 RBM12 LMNA LMNB1 BTBD7

7.09e-07189155105248_DN
Drug(+) -Levobunolol hydrochloride [47141-41-3]; Down 200; 12.2uM; MCF7; HT_HG-U133A

DTNA ST7 CNTRL IQSEC2 TSGA10 APLP1 NPFFR1 LIN7B UBE2B CBFA2T2

1.04e-06197155103355_DN
Drugsu-w

PRPF6 LIPE IMMT

3.06e-0651553CID000447612
DrugApigenin [520-36-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A

UBR2 SPAST ABHD3 WWTR1 UBE2B RBM12 LMNB1 MAD1L1 PDZRN3

5.87e-0618815593257_DN
DrugRibavirin [36791-04-5]; Down 200; 16.4uM; MCF7; HT_HG-U133A

PDE3B DTNA IQSEC2 NPFFR1 TFAP4 LMNA MEGF8 DNAH17 ATM

8.57e-0619715596018_DN
DrugNadide [53-84-9]; Down 200; 6uM; MCF7; HT_HG-U133A

CNTRL APBA2 SLC24A3 TFAP4 BTBD7 DNAH17 TMOD1 TSC22D4 RIMS2

8.57e-0619715596091_DN
DrugTheophylline monohydrate [5967-84-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A

SLC12A6 DTNA ST7 CNTRL IQSEC2 APLP1 B4GALT6 CBFA2T2 ATM

8.93e-0619815593326_DN
DrugHymecromone [90-33-5]; Down 200; 22.8uM; MCF7; HT_HG-U133A

RPH3AL CNTRL APLP1 NPFFR1 TIGD6 LMNA BTBD7 TMOD1 TSC22D4

8.93e-0619815595684_DN
DrugClebopride maleate [84370-95-6]; Up 200; 8.2uM; MCF7; HT_HG-U133A

PDE3B RPH3AL DTNA CNTRL SLC24A3 ITPR1 ACOT11 SMARCA1 TMOD1

9.30e-0619915595412_UP
Diseasesurvival time

MCM10 XCL2 XCL1

1.04e-0591493EFO_0000714
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 LMNA LMNB1

2.68e-05121493DOID:11726 (implicated_via_orthology)
Diseaseautosomal recessive Emery-Dreifuss muscular dystrophy 3 (implicated_via_orthology)

LMNA LMNB1

7.57e-0531492DOID:0070248 (implicated_via_orthology)
Diseasecongenital muscular dystrophy due to LMNA mutation (implicated_via_orthology)

LMNA LMNB1

7.57e-0531492DOID:0110640 (implicated_via_orthology)
Diseasefamilial partial lipodystrophy type 2 (implicated_via_orthology)

LMNA LMNB1

7.57e-0531492DOID:0070202 (implicated_via_orthology)
Diseaseautosomal dominant Emery-Dreifuss muscular dystrophy 2 (implicated_via_orthology)

LMNA LMNB1

7.57e-0531492DOID:0070247 (implicated_via_orthology)
Diseaselymphotactin measurement

XCL2 XCL1

1.51e-0441492EFO_0008214
Diseasedilated cardiomyopathy 1A (implicated_via_orthology)

LMNA LMNB1

1.51e-0441492DOID:0110425 (implicated_via_orthology)
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 LMNA

1.51e-0441492cv:CN293514
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 LMNA

2.51e-0451492C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 LMNA

2.51e-0451492C0410190
DiseaseFamilial partial lipodystrophy

LIPE LMNA

2.51e-0451492cv:C0271694
DiseaseEpithelioid hemangioendothelioma

WWTR1 CAMTA1

2.51e-0451492C0206732
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 LMNA

3.75e-0461492cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 LMNA

3.75e-0461492C0410189
Diseasecongenital muscular dystrophy (implicated_via_orthology)

LMNA LMNB1

3.75e-0461492DOID:0050557 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

CHD7 ITPR1 UBE2A UBE2B

4.18e-04691494DOID:1682 (implicated_via_orthology)
DiseaseFamilial Partial Lipodystrophy, Type 3

LIPE LMNA

5.23e-0471492C1720861
DiseaseFamilial Partial Lipodystrophy, Type 2

LIPE LMNA

5.23e-0471492C1720860
DiseaseFamilial Partial Lipodystrophy, Type 1

LIPE LMNA

5.23e-0471492C1720859
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 LMNA

5.23e-0471492C0751337
DiseaseFamilial hyperinsulinism

GCK GLUD1

6.95e-0481492cv:C3888018
DiseaseFamilial partial lipodystrophy

LIPE LMNA

6.95e-0481492C0271694
Diseasehypoglycemia (is_implicated_in)

GCK GLUD1

6.95e-0481492DOID:9993 (is_implicated_in)
Diseaseprogeria (implicated_via_orthology)

LMNA LMNB1

6.95e-0481492DOID:3911 (implicated_via_orthology)
Diseasenon-alcoholic fatty liver disease (implicated_via_orthology)

UBR2 UBE2A UBE2B

7.97e-04361493DOID:0080208 (implicated_via_orthology)
Diseaseneurodegenerative disease (implicated_via_orthology)

UBR2 WWTR1 GRIK2 SLC17A7 CLEC16A

8.67e-041451495DOID:1289 (implicated_via_orthology)
Diseasenephronophthisis (implicated_via_orthology)

CNTRL WWTR1

8.91e-0491492DOID:12712 (implicated_via_orthology)
Diseaseheart disease (implicated_via_orthology)

SOX6 WWTR1 LIPE

9.35e-04381493DOID:114 (implicated_via_orthology)
DiseaseInherited neuropathies

SPAST ITPR1 ATM

1.09e-03401493C0598589
DiseaseCongenital small ears

CHD7 ORC1 PLCB4

1.17e-03411493C0152423
DiseaseNeurodevelopmental Disorders

TANC2 SPAST IQSEC2 ITPR1

1.29e-03931494C1535926
DiseaseSepsis, mortality

GTF3C5 MAD1L1

1.35e-03111492EFO_0004352, HP_0100806
Diseasehyperinsulinism (is_implicated_in)

GCK GLUD1

1.62e-03121492DOID:2018 (is_implicated_in)
DiseaseBell's palsy

SUPT3H GRIK2 XCL2 CEP295

1.81e-031021494EFO_0007167
Diseasepsychosis

SLC24A3 FAM98B

2.21e-03141492EFO_0005407
DiseaseLeft ventricular noncompaction

DTNA LMNA

2.21e-03141492C1960469
Diseaseplasminogen activator inhibitor 1 measurement

UBR4 MAD1L1 PLG

2.59e-03541493EFO_0004792
Diseasesyndromic intellectual disability (implicated_via_orthology)

UBE2A UBE2B

2.90e-03161492DOID:0050888 (implicated_via_orthology)
Diseaseprimary autosomal recessive microcephaly (is_implicated_in)

NCAPD3 LMNB1

2.90e-03161492DOID:0070296 (is_implicated_in)
DiseaseMonogenic diabetes

GCK LMNA

2.90e-03161492C3888631
Diseasetriacylglycerol 48:1 measurement

SPAG9 LMNA

3.28e-03171492EFO_0010404
Diseaseuterine fibroid

RAD18 SYNE1 DNAH2 ITPR1 ATM

3.47e-031991495EFO_0000731
Diseasecolorectal health

RAD18 ST7 GRIK2 MAD1L1 HACE1

3.62e-032011495EFO_0008460
DiseaseFEV/FEC ratio

ARHGAP42 SLC26A9 SLC24A3 WWTR1 TFAP4 FAM83H ITPR1 PTPN4 UBE2A BRDT ANAPC1 TMOD1 CLEC16A PDZRN3

3.82e-03122814914EFO_0004713
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

DNAH10 GCK JMY BUD23 PLG

4.01e-032061495EFO_0004612, EFO_0020947
Diseaseneck circumference

ANKRD33 PDZRN3

4.09e-03191492EFO_0011043
Diseasecortical surface area change measurement, age at assessment

SPAG9 CFAP99

4.09e-03191492EFO_0008007, EFO_0021503
Diseasesensorineural hearing loss (implicated_via_orthology)

PSMC3 DNAH17

4.09e-03191492DOID:10003 (implicated_via_orthology)
DiseaseFetal Growth Retardation

ORC1 GLUD1

4.53e-03201492C0015934
DiseaseAdenocarcinoma of prostate

MAD1L1 ATM

4.53e-03201492C0007112
Diseaseunipolar depression, mood disorder

SOX6 DPY19L3 MAD1L1 CAMTA1

4.83e-031341494EFO_0003761, EFO_0004247
Diseasemuscular dystrophy (implicated_via_orthology)

LMNA LMNB1

4.99e-03211492DOID:9884 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
MAENRKSSIIIRMRD

PLGLB1

76

Q02325
RLREIMRSRQEMKNP

CCDC137

66

Q6PK04
YVRNSRMIDIQTRMA

BUD23

26

O43709
MEIGRSAEMQQRIRS

CFAP54

1401

Q96N23
RMSILERLEQMERRM

CAMTA1

976

Q9Y6Y1
LERRQMEISDAMRTL

CNTRL

2146

Q7Z7A1
DMATRLVAARLMVRN

ACAD8

321

Q9UKU7
EIRRARRMPMNKNEL

B4GAT1

261

O43505
RRREAMVGTIDMTLQ

BRDT

921

Q58F21
IQMERMRTVNAMAVR

ABCA9

1261

Q8IUA7
LRAKMDLEERRMRQI

APLP1

311

P51693
MQRLAMDLRMLSREL

ABHD3

1

Q8WU67
KMEHSVAAERRRMRL

ACOT11

171

Q8WXI4
IVVLMARRRMPRSAS

APBA2

466

Q99767
MCVLRMTRARRSQVE

ATAD2

1291

Q6PL18
MMSIRQRREIRATEV

DPY19L3

1

Q6ZPD9
RQQMRQEALMKTDRR

CHD7

1926

Q9P2D1
KRRNLMEMVAQLRES

CHD7

2416

Q9P2D1
MDAVRIMAKDLVRTR

CHMP2A

56

O43633
RIMVSRSELDMLDIR

ANXA6

276

P08133
KTEMQNMIELSRRRF

RBM12

76

Q9NTZ6
TFEALKRNRMLMIQR

RBM12

356

Q9NTZ6
KRNRMLMIQRYVEVS

RBM12

361

Q9NTZ6
KEQRRRREFMMQSRL

PDZRN3

986

Q9UPQ7
RDQRGLTALMKAAMR

ANKRD33

196

Q7Z3H0
RMRLEASKLNESVMV

RAD18

311

Q9NS91
RMLMRREQVLKVCAN

RGPD5

1096

Q99666
RMLMRREQVLKVCAN

RGPD8

1096

O14715
ERERIRQRMKMVIGQ

INSYN1

21

Q2T9L4
LDIVRTMRDQRAMMI

PTPN4

881

P29074
NRMRESRSEDVMRIT

GCK

391

P35557
KRFTRVEMARVLMER

SPAG9

501

O60271
IAMDQAIRRLGRREM

ANAPC1

1791

Q9H1A4
EQMAKLMLQRAERRL

CFAP99

386

D6REC4
ASRRRARVVHMLVMV

NPFFR1

261

Q9GZQ6
IYTLRNQEMKSAMRR

OR4D11

286

Q8NGI4
KFLQETMTEMARRNR

LETM2

231

Q2VYF4
TMDRRKAATMRERRR

MYF5

81

P13349
EMLRRVDAENRLQTM

LMNA

186

P02545
MEARFEKMRSARRRQ

LIN7B

181

Q9HAP6
LTRRMREAEDMVQKV

MAD1L1

431

Q9Y6D9
RELAMLRRQQIKISM

JMY

391

Q8N9B5
FQTLIQMMRSERDRM

ITPR1

1361

Q14643
RRRDVASAMQQMLTE

LRSAM1

381

Q6UWE0
MSENRMSRRIVLSNM

IQSEC1

161

Q6DN90
MSRRIVLSNMRMQFS

IQSEC1

166

Q6DN90
ESRMSRRIILSNMRM

IQSEC2

376

Q5JU85
RRIILSNMRMQFSFE

IQSEC2

381

Q5JU85
ISEMNRMIQRLRAEI

KRT5

386

P13647
VNSAREELMESRMRI

LMNB1

286

P20700
MSSKQEIMSDQRFRR

ESF1

1

Q9H501
TRREMQSVVQLIMTR

ESF1

206

Q9H501
MVEKTRRSMAVLRRC

CBFA2T2

361

O43439
IRAREQRKRREFMMQ

PDZD4

686

Q76G19
QRKRREFMMQSRLEC

PDZD4

691

Q76G19
MRRDERDAKAMRSLQ

PDE3B

1

Q13370
SAKQRLSLRRMVIDM

PDE4C

481

Q08493
FQRRAKAMMLRAAVL

GPS1

446

Q13098
MERAMEQLNRLTRSL

HACE1

1

Q8IYU2
EQRRHLQEMTKMASR

MEGF8

2681

Q7Z7M0
ITVRNNRIIMRMEYL

MRS2

126

Q9HD23
VRDAMENEMRTQLRR

IMMT

471

Q16891
KQRMLEMRRRKSEEI

MCM10

566

Q7L590
SLRNKDVTRALRSMM

OR2T34

296

Q8NGX1
DVTRALRSMMQSRMN

OR2T34

301

Q8NGX1
SLRNKDVTRALRSMM

OR2T3

296

Q8NH03
DVTRALRSMMQSRMN

OR2T3

301

Q8NH03
MRLMKEVRGRNQTEV

OR5AP2

1

Q8NGF4
NSRERKRMQDLNLAM

OLIG1

111

Q8TAK6
RTEIRMARMARKAGN

RPL7

66

P18124
RSMQAKMLEQRRRLA

IQCF6

21

A8MYZ5
KTRLSMASRMLINER

SLC24A3

341

Q9HC58
VMRMKEFERERRLLQ

NDUFB7

96

P17568
DSRISMLRMDRPSRQ

RIMS2

411

Q9UQ26
MLRMDRPSRQRSISE

RIMS2

416

Q9UQ26
SPDLQSMEQIRRIMR

PPP1CB

176

P62140
TVRVIRMKNVRQADM

PLA2G4E

71

Q3MJ16
MDLPERIMMNRVSSR

ORC1

656

Q13415
SRQLEKRMSEEMRLL

ITPRIPL1

41

Q6GPH6
IRARRKTARMLMIVL

HCRTR2

296

O43614
QRTMLAVVDYMRRQK

ATM

1906

Q13315
LQEMSEKMRSLQERR

CSGALNACT2

86

Q8N6G5
RRQMKMLDSENTRLG

CROCC

1286

Q5TZA2
MERLRELQRASILDM

FBF1

691

Q8TES7
MSVLRRMMRVSNRSL

B4GALT6

1

Q9UBX8
ERMNILTNEMRRSLK

DNAH17

4236

Q9UFH2
RSARQIMRTAMKYNL

GLUD1

516

P00367
KMIRAMELAVARRET

CCDC40

956

Q4G0X9
RRRMLMKRLDVTVQS

FAM98B

221

Q52LJ0
MVEQTDLVRLRMVRM

BTBD7

591

Q9P203
RQEMVNLRATDVRLM

LURAP1L

101

Q8IV03
RLSSEMTISMRQRLA

MAPKBP1

731

O60336
TMAERRQLFAEMRAQ

DTNA

11

Q9Y4J8
RMSALQESRRELMVQ

DTNA

531

Q9Y4J8
ELNMEIRDMIRRAQS

FRY

2981

Q5TBA9
DRTRLRKAQSMMSRR

FBXO16

271

Q8IX29
RRMIRSAQQVVAVVM

FAM83H

141

Q6ZRV2
MVEELRMSLKCQRRL

GRIK2

861

Q13002
LMTINRMEQARTEYR

ICA1L

146

Q8NDH6
ARIRMSARQKQIMEI

CEP295

501

Q9C0D2
MTAVLNEMRRTNRLI

DNAH10

1641

Q8IVF4
LREDVVLMRALRDMN

DNAH10

2026

Q8IVF4
IRLDRMMEDALRLNV

DNAH2

826

Q9P225
QRSQMLRHMRLSKTE

SLC12A6

996

Q9UHW9
ERSGINRLRSEMKQM

PHKA2

996

P46019
NRLRSEMKQMTRRFS

PHKA2

1001

P46019
MLDDSVMLARRLRNL

LIPE

996

Q05469
IYTLRNQDMKAAMRR

OR4D1

286

Q15615
MTQFLSIIRSRMVLR

MAP1LC3C

66

Q9BXW4
RLQKALDSVMSIREM

PARP6

381

Q2NL67
RMLMRRDQVLKVCAN

RGPD1

1081

P0DJD0
RTMMLLAQMRRISLF

IFNA6

36

P05013
LVERLETMRRNVMGN

RPH3AL

76

Q9UNE2
DMREAASLRQQRRMK

NRIP3

16

Q9NQ35
PMMITNAERLRRKRA

MRPS16

101

Q9Y3D3
DAIMSRRAIRNMNTL

SYVN1

261

Q86TM6
AVRRVVAAMNRMDQK

UVSSA

681

Q2YD98
MASRIGLRMQLMREQ

TFEB

1

P19484
MQVDARMKRAERRIL

TIGD6

266

Q17RP2
RMISKEIRQVVRMTS

RAPGEF6

1041

Q8TEU7
TDTIRKEFRTRMVMN

PLCB4

731

Q15147
RLQKMGESSLRNFRM

SMARCA1

706

P28370
RNICAMSMERRLKIE

SYNE1

7981

Q8NF91
PLSRRKAVDMRLRME

TSC22D4

231

Q9Y3Q8
RMRPTQQRRSLFMKT

SLC26A9

576

Q7LBE3
STRQEVERLMQRMKS

ARHGAP42

241

A6NI28
RKIGQARNTLMDMRL

PRPF6

241

O94906
DNCDSIIRRLMKMNR

LARS1

1091

Q9P2J5
LQRKRTQQDRRMEME

IQCA1L

221

A6NCM1
VEDRRAAMERQLISM

SPDL1

261

Q96EA4
ENLSMFLIKRRDMTR

TANC2

746

Q9HCD6
RSRRIMSTTNVRKLM

SLC17A7

366

Q9P2U7
CERARRLQAKMMTNL

SPAST

171

Q9UBP0
ARRLGRTREAVKMMR

ST7

306

Q9NRC1
MAENRKSSIIIRMRD

PLG

76

P00747
LEEAKMMNRLRHSRV

RIPK1

61

Q13546
QRSQMLRQMRLTKTE

SLC12A4

931

Q9UP95
KQLMRSRRQEMRQFF

SOX6

711

P35712
CVMAMLRRRIRDEKT

NCAPD3

541

P42695
GRIQARRMKMQRIAA

CLEC16A

811

Q2KHT3
VRSMDRKSNTRNNMI

XCL1

81

P47992
VRSMDRKSNTRNNMI

XCL2

81

Q9UBD3
MVRKITLSRAVRTMQ

TTLL11

281

Q8NHH1
ERSHQIERMMSRIFR

TMPRSS11F

86

Q6ZWK6
RMERAERQTRIMDSA

SUPT3H

166

O75486
RGRAAMIQVLSREEM

TRPM6

1761

Q9BX84
PMNTRMIRKRNSLIA

TIGD1

66

Q96MW7
AMMNNNDLVRKRRLA

TMOD1

331

P28289
ARARIMQIHSRKMNV

PSMC3

361

P17980
MSTPARRRLMRDFKR

UBE2A

1

P49459
QRERMMTRLANKLRG

ZDBF2

2336

Q9HCK1
VRGEAIRIRTMKMRQ

TEK

106

Q02763
IRIRTMKMRQQASFL

TEK

111

Q02763
RIRVTSERVENMSMR

TRPM1

1181

Q7Z4N2
AQEEITRLRREMMKS

TSGA10

71

Q9BZW7
SRDQRRKMALENPRM

SRY

71

Q05066
RKMALENPRMRNSEI

SRY

76

Q05066
ELRDTMSLMIRQTIR

GTF3C5

446

Q9Y5Q8
TRPRMTVEEQMERIR

PLEKHA5

896

Q9HAU0
EIARLRREKIMAQMS

UBR2

1036

Q8IWV8
MREEVRQLMCLLTRD

UBR4

3921

Q5T4S7
RSVRMMLEEQVRSLE

TFAP4

166

Q01664
MSTPARRRLMRDFKR

UBE2B

1

P63146
RSMLESMLNRILAVR

ZMYM3

1341

Q14202
QRLIEARRMMDKLRA

YEATS2

66

Q9ULM3
ARRMMDKLRACIVAN

YEATS2

71

Q9ULM3
RMLQIPNRSLDRAKM

MRPL17

106

Q9NRX2
RIRMRQEELMRQEAA

WWTR1

246

Q9GZV5
LMSTMRNQARLKVLR

ATP6V1E2

71

Q96A05
EMNAMLARRRKATQV

VASP

266

P50552
LRSMFSKVREMLRMR

ZSWIM4

281

Q9H7M6
EISEMNRMIQRLRAE

KRT75

366

O95678