Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	6.18e-28	114	114	22	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	4.53e-27	124	114	22	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	4.68e-26	137	114	22	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	1.05e-22	192	114	22	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	PCSK5 USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 AGBL5 USP17L18 USP17L17 FURIN USP17L6P USP17L3 USP12 USP17L22 CPVL USP17L15 USP17L8 USP17L13	3.46e-15	654	114	26	GO:0008233
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	1.04e-25	125	113	21	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	2.39e-24	144	113	21	GO:0070646
GeneOntologyBiologicalProcess	post-translational protein modification	UBR1 USP17L21 USP17L4 RNF152 USP17L2 USP17L12 USP17L1 TRIM42 USP17L20 USP17L11 KLHL40 USP17L24 USP17L5 USP17L10 USP46 USP17L19 AGBL5 USP17L18 USP17L17 USP17L6P USP17L3 USP12 MED23 USP17L22 USP17L15 USP17L8 USP17L13	1.84e-11	1074	113	27	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	UBR1 USP17L21 USP17L4 RNF152 USP17L2 USP17L12 USP17L1 TRIM42 USP17L20 USP17L11 KLHL40 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 MED23 USP17L22 USP17L15 USP17L8 USP17L13	2.73e-11	1009	113	26	GO:0070647
GeneOntologyBiologicalProcess	dense core granule docking	UNC13B UNC13A	2.98e-05	2	113	2	GO:0061790
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 PANX2 ATP10A USP17L18 USP17L17 FURIN USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	9.16e-06	1293	117	21	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 PANX2 ATP10A USP17L18 USP17L17 FURIN USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	9.83e-06	1299	117	21	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 PANX2 ATP10A USP17L18 USP17L17 FURIN USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.36e-05	1327	117	21	GO:0042175
GeneOntologyCellularComponent	basement membrane	FRAS1 VTN PAPLN NTN4 ENTPD1	6.21e-04	122	117	5	GO:0005604
MousePheno	increased trophectoderm apoptosis	USP17L2 USP17L15 USP17L13	8.48e-06	8	76	3	MP:0012119
Domain	HABP4_PAI-RBP1	USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L13	3.08e-27	16	111	13	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L13	3.08e-27	16	111	13	IPR006861
Domain	UCH	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L8 USP17L13	6.80e-27	71	111	19	PF00443
Domain	USP_2	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L8 USP17L13	6.80e-27	71	111	19	PS00973
Domain	USP_3	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L8 USP17L13	9.19e-27	72	111	19	PS50235
Domain	USP_dom	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L8 USP17L13	9.19e-27	72	111	19	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L8 USP17L13	9.19e-27	72	111	19	IPR001394
Domain	USP_CS	USP17L21 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L8 USP17L13	1.10e-25	66	111	18	IPR018200
Domain	USP_1	USP17L21 USP17L4 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP46 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L8 USP17L13	3.64e-25	70	111	18	PS00972
Domain	Unc-13	UNC13B UNC13A	1.05e-04	3	111	2	IPR027080
Domain	Furin_repeat	PCSK5 FRAS1 FURIN	1.56e-04	18	111	3	IPR006212
Domain	FU	PCSK5 FRAS1 FURIN	1.56e-04	18	111	3	SM00261
Domain	Munc13_dom-2	UNC13B UNC13A	3.46e-04	5	111	2	IPR014772
Domain	Membr_traf_MHD	UNC13B UNC13A	3.46e-04	5	111	2	PF10540
Domain	MHD2	UNC13B UNC13A	3.46e-04	5	111	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B UNC13A	3.46e-04	5	111	2	IPR019558
Domain	DUF1041	UNC13B UNC13A	3.46e-04	5	111	2	SM01145
Domain	Peptidase_S8_Asp-AS	PCSK5 FURIN	5.17e-04	6	111	2	IPR023827
Domain	DUF1041	UNC13B UNC13A	7.21e-04	7	111	2	PF06292
Domain	Munc13_1	UNC13B UNC13A	7.21e-04	7	111	2	IPR014770
Domain	PrprotnconvertsP	PCSK5 FURIN	7.21e-04	7	111	2	IPR002884
Domain	CAPS_dom	UNC13B UNC13A	7.21e-04	7	111	2	IPR010439
Domain	TLV_coat	ERVV-2 ERVV-1	7.21e-04	7	111	2	PF00429
Domain	MHD1	UNC13B UNC13A	7.21e-04	7	111	2	PS51258
Domain	P_proprotein	PCSK5 FURIN	7.21e-04	7	111	2	PF01483
Domain	S8_pro-domain	PCSK5 FURIN	7.21e-04	7	111	2	IPR032815
Domain	-	PCSK5 FURIN	7.21e-04	7	111	2	3.30.70.850
Domain	S8_pro-domain	PCSK5 FURIN	7.21e-04	7	111	2	PF16470
Domain	AP_complex_ssu	AP2S1 AP1S2	7.21e-04	7	111	2	IPR016635
Domain	TLV/ENV_coat_polyprotein	ERVV-2 ERVV-1	9.57e-04	8	111	2	IPR018154
Domain	Peptidase_S8_His-AS	PCSK5 FURIN	1.23e-03	9	111	2	IPR022398
Domain	CLAT_ADAPTOR_S	AP2S1 AP1S2	1.23e-03	9	111	2	PS00989
Domain	Peptidase_S8_Ser-AS	PCSK5 FURIN	1.23e-03	9	111	2	IPR023828
Domain	VWC	FRAS1 JAG1 BMPER	1.48e-03	38	111	3	SM00214
Domain	Peptidase_S8_subtilisin-rel	PCSK5 FURIN	1.53e-03	10	111	2	IPR015500
Domain	SUBTILASE_ASP	PCSK5 FURIN	1.53e-03	10	111	2	PS00136
Domain	SUBTILASE_HIS	PCSK5 FURIN	1.53e-03	10	111	2	PS00137
Domain	SUBTILASE_SER	PCSK5 FURIN	1.53e-03	10	111	2	PS00138
Domain	-	PCSK5 FURIN	1.86e-03	11	111	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK5 FURIN	1.86e-03	11	111	2	IPR000209
Domain	Peptidase_S8	PCSK5 FURIN	1.86e-03	11	111	2	PF00082
Domain	VWF_dom	FRAS1 JAG1 BMPER	1.98e-03	42	111	3	IPR001007
Domain	Clathrin_sm-chain_CS	AP2S1 AP1S2	2.22e-03	12	111	2	IPR000804
Domain	Growth_fac_rcpt_	PCSK5 FRAS1 NTN4 FURIN JAG1	2.40e-03	156	111	5	IPR009030
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH9	3.04e-03	14	111	2	IPR024317
Domain	PLAC	PCSK5 PAPLN	3.04e-03	14	111	2	PF08686
Domain	Dynein_heavy_dom-2	DNAH12 DNAH9	3.04e-03	14	111	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH9	3.04e-03	14	111	2	PF08393
Domain	AAA_8	DNAH12 DNAH9	3.04e-03	14	111	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH9	3.04e-03	14	111	2	IPR011704
Domain	AAA_5	DNAH12 DNAH9	3.04e-03	14	111	2	PF07728
Domain	DHC_fam	DNAH12 DNAH9	3.49e-03	15	111	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH9	3.49e-03	15	111	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH9	3.49e-03	15	111	2	PF03028
Domain	AP_mu_sigma_su	AP2S1 AP1S2	3.98e-03	16	111	2	IPR022775
Domain	Clat_adaptor_s	AP2S1 AP1S2	3.98e-03	16	111	2	PF01217
Domain	Propept_inh	PCSK5 FURIN	4.49e-03	17	111	2	IPR009020
Domain	VWC_out	FRAS1 JAG1	5.60e-03	19	111	2	SM00215
Domain	PLAC	PCSK5 PAPLN	5.60e-03	19	111	2	PS50900
Domain	PLAC	PCSK5 PAPLN	5.60e-03	19	111	2	IPR010909
Domain	GPCR_Rhodpsn_7TM	OR8J3 UTS2R GPR21 OR13C8 GPR52 OR8J1 APLNR MTNR1B OR4C46 OR4C13	6.59e-03	670	111	10	IPR017452
Domain	C1	UNC13B KMT2C UNC13A	6.83e-03	65	111	3	SM00109
Domain	7tm_1	OR8J3 UTS2R GPR21 OR13C8 GPR52 OR8J1 APLNR MTNR1B OR4C46 OR4C13	7.07e-03	677	111	10	PF00001
Domain	PE/DAG-bd	UNC13B KMT2C UNC13A	7.12e-03	66	111	3	IPR002219
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	7.64e-29	45	90	18	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	8.06e-18	191	90	19	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	1.27e-16	221	90	19	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	2.99e-15	262	90	19	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	3.35e-14	299	90	19	M27574
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 CSF2RB USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.02e-13	318	90	19	MM15278
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L4 RNF152 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 MDGA2 USP17L10 USP17L19 AGBL5 USP17L18 USP17L17 FURIN TEX101 USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	1.17e-05	1475	90	24	M19806
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L4 RNF152 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 FURIN TEX101 USP17L6P USP17L3 USP12 USP17L22 USP17L15 USP17L8 USP17L13	4.54e-05	1389	90	22	MM15307
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.41e-42	21	119	18	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.41e-42	21	119	18	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.41e-42	21	119	18	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.41e-42	21	119	18	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.41e-42	21	119	18	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.41e-42	21	119	18	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	7.75e-42	22	119	18	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.42e-40	24	119	18	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.05e-40	25	119	18	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.64e-39	26	119	18	35816173
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.45e-39	33	119	19	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	20403174
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	14699124
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	11941478
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.55e-39	34	119	19	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.21e-38	35	119	19	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.21e-38	35	119	19	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.56e-38	36	119	19	20147298
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	3.60e-38	29	119	18	32527007
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.24e-38	37	119	19	20228808
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.77e-32	50	119	18	31806660
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	5.46e-16	10	119	7	24207026
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 LCA5L ZNF521 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 AP1S2 USP17L22 CPVL USP17L15 USP17L8 USP17L13	1.33e-15	674	119	22	37196079
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	3.58e-15	12	119	7	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	1.54e-14	14	119	7	11793228
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	2.24e-13	19	119	7	28067227
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L4 USP17L2 USP17L1 USP46 USP17L6P USP17L3 USP12 USP17L15 USP17L8	1.00e-11	81	119	9	12838346
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L19 USP17L18 NTN4 USP17L17	8.46e-09	119	119	8	28625976
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L2 USP17L15 USP17L13	1.56e-07	4	119	3	22984479
Pubmed	Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.	UNC13B UNC13A	1.16e-05	2	119	2	12070347
Pubmed	Regulation of insulin exocytosis by Munc13-1.	UNC13B UNC13A	1.16e-05	2	119	2	12871971
Pubmed	Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.	UNC13B UNC13A	1.16e-05	2	119	2	17561838
Pubmed	Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.	UNC13B UNC13A	1.16e-05	2	119	2	23070049
Pubmed	Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.	UNC13B UNC13A	1.16e-05	2	119	2	28489077
Pubmed	Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.	UNC13B UNC13A	1.16e-05	2	119	2	10440375
Pubmed	Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.	UNC13B UNC13A	1.16e-05	2	119	2	22066784
Pubmed	Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.	UNC13B UNC13A	1.16e-05	2	119	2	32187536
Pubmed	In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.	PCSK5 FURIN	1.16e-05	2	119	2	34149625
Pubmed	Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.	UNC13B UNC13A	1.16e-05	2	119	2	28772123
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	1.16e-05	2	119	2	18826608
Pubmed	Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.	UNC13B UNC13A	1.16e-05	2	119	2	17267576
Pubmed	Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.	UNC13B UNC13A	1.16e-05	2	119	2	22814762
Pubmed	Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.	PCSK5 FURIN	1.16e-05	2	119	2	10888676
Pubmed	Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans.	CMIP MTNR1B	1.16e-05	2	119	2	29691896
Pubmed	Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.	UNC13B UNC13A	1.16e-05	2	119	2	28426965
Pubmed	A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.	UNC13B UNC13A	1.16e-05	2	119	2	35613050
Pubmed	Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.	UNC13B UNC13A	1.16e-05	2	119	2	23770256
Pubmed	Membrane bridging by Munc13-1 is crucial for neurotransmitter release.	UNC13B UNC13A	1.16e-05	2	119	2	30816091
Pubmed	A common molecular basis for membrane docking and functional priming of synaptic vesicles.	UNC13B UNC13A	1.16e-05	2	119	2	19558619
Pubmed	Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.	UNC13B UNC13A	1.16e-05	2	119	2	18701688
Pubmed	Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.	UNC13B UNC13A	1.16e-05	2	119	2	31851910
Pubmed	The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.	USP46 USP12	1.16e-05	2	119	2	25855980
Pubmed	Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.	UNC13B UNC13A	1.16e-05	2	119	2	11832228
Pubmed	Munc13 controls the location and efficiency of dense-core vesicle release in neurons.	UNC13B UNC13A	1.16e-05	2	119	2	23229896
Pubmed	Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.	UNC13B UNC13A	1.16e-05	2	119	2	11792326
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	1.16e-05	2	119	2	23555306
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L4 USP17L1 USP17L3 USP17L8	2.26e-05	48	119	4	16421571
Pubmed	Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.	UNC13B UNC13A	3.47e-05	3	119	2	37343100
Pubmed	In vivo evidence that furin from hepatocytes inactivates PCSK9.	PCSK5 FURIN	3.47e-05	3	119	2	21147780
Pubmed	The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.	PCSK5 FURIN	3.47e-05	3	119	2	16912035
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13B UNC13A	3.47e-05	3	119	2	23658173
Pubmed	Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.	PCSK5 FURIN	3.47e-05	3	119	2	8670066
Pubmed	Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.	UNC13B UNC13A	3.47e-05	3	119	2	17639022
Pubmed	Thrombin activation of protein C requires prior processing by a liver proprotein convertase.	PCSK5 FURIN	3.47e-05	3	119	2	28468828
Pubmed	Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.	PCSK5 FURIN	3.47e-05	3	119	2	11723118
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13B UNC13A	3.47e-05	3	119	2	33105896
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13B UNC13A	3.47e-05	3	119	2	22966208
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13B UNC13A	3.47e-05	3	119	2	15988013
Pubmed	Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1.	ZEB1 JAG1	3.47e-05	3	119	2	33046710
Pubmed	Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.	UNC13B UNC13A	6.93e-05	4	119	2	10488064
Pubmed	CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.	PCSK5 FURIN	6.93e-05	4	119	2	16829522
Pubmed	Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.	PCSK5 FURIN	6.93e-05	4	119	2	8615794
Pubmed	Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.	PCSK5 FURIN	6.93e-05	4	119	2	23686857
Pubmed	Neurotrophin secretion: current facts and future prospects.	PCSK5 FURIN	6.93e-05	4	119	2	12787574
Pubmed	A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.	USP46 USP12	6.93e-05	4	119	2	27650958
Pubmed	WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc.	USP46 USP12	6.93e-05	4	119	2	39432777
Pubmed	AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.	AP2S1 AP1S2	6.93e-05	4	119	2	2040623
Pubmed	The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.	USP46 USP12	6.93e-05	4	119	2	33844468
Pubmed	Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.	UNC13B UNC13A	6.93e-05	4	119	2	19996097
Pubmed	Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.	UNC13B UNC13A	6.93e-05	4	119	2	15123597
Pubmed	ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.	UNC13B UNC13A	6.93e-05	4	119	2	28264913
Pubmed	Proprotein convertase furin regulates osteocalcin and bone endocrine function.	PCSK5 FURIN	6.93e-05	4	119	2	28972540
Pubmed	The proprotein convertases furin and PACE4 play a significant role in tumor progression.	PCSK5 FURIN	6.93e-05	4	119	2	10900462
Pubmed	Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.	PCSK5 FURIN	6.93e-05	4	119	2	18245819
Pubmed	E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication.	USP46 USP12	6.93e-05	4	119	2	24850727
Pubmed	Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.	PCSK5 FURIN	6.93e-05	4	119	2	9521771
Pubmed	Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.	PCSK5 FURIN	6.93e-05	4	119	2	15911696
Pubmed	WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.	USP46 USP12	6.93e-05	4	119	2	30466959
Pubmed	An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.	UNC13B UNC13A	1.15e-04	5	119	2	34706221
Pubmed	UAF1 is a subunit of multiple deubiquitinating enzyme complexes.	USP46 USP12	1.15e-04	5	119	2	19075014
Pubmed	WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.	USP46 USP12	1.15e-04	5	119	2	20147737
Pubmed	A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.	UNC13B UNC13A	1.15e-04	5	119	2	32755572
Cytoband	4p16.1	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	3.01e-24	79	119	15	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	3.04e-17	222	119	15	chr4p16
Cytoband	8p23.1	USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.34e-05	154	119	5	8p23.1
Cytoband	18q11.2	TMEM241 ABHD3 ZNF521	2.53e-04	47	119	3	18q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	3.75e-04	234	119	5	chr8p23
Cytoband	Ensembl 112 genes in cytogenetic band chr18q11	TMEM241 ABHD3 ZNF521	1.44e-03	85	119	3	chr18q11
Cytoband	3p14.3	DNAH12 ARHGEF3	2.76e-03	30	119	2	3p14.3
GeneFamily	UNC13 homologs	UNC13B UNC13A	1.04e-04	4	76	2	836
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK5 FURIN	6.16e-04	9	76	2	973
GeneFamily	Olfactory receptors, family 8	OR8J2 OR8J3 OR8J1	1.14e-03	49	76	3	155
GeneFamily	Ubiquitin specific peptidases	USP17L2 USP46 USP12	1.69e-03	56	76	3	366
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZEB1 TSHZ1	1.77e-03	15	76	2	529
GeneFamily	Dyneins, axonemal	DNAH12 DNAH9	2.28e-03	17	76	2	536
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZEB1 ZNF560 ZNF813 ZNF521 ZNF519 ZNF441 ZFX RLF TSHZ1	3.09e-03	718	76	9	28
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	9.11e-26	86	114	18	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.55e-23	112	114	18	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 FHL2 USP17L22 USP17L15 USP17L8 USP17L13	3.48e-22	160	114	19	MM1155
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	UBR1 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 HSPBAP1 USP17L11 USP17L5 USP17L10 USP17L19 ITGAL USP17L18 SLC26A8 LRP10 USP17L17 USP17L6P USP17L3 TSHZ1 FHL2 USP17L22 USP17L15 USP17L8 USP17L13	4.56e-12	1072	114	25	MM1031
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 INPP5B USP17L5 USP17L10 USP17L19 USP17L18 SIDT2 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.82e-12	647	114	20	MM981
Coexpression	BRUINS_UVC_RESPONSE_LATE	TCTN3 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 CMIP USP17L17 PPIL3 USP17L6P USP17L3 USP12 BMPER USP17L22 USP17L15 USP17L8 USP17L13	1.66e-09	1198	114	23	MM1062
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 INPP5B USP17L5 USP17L10 USP17L19 USP17L18 SIDT2 USP17L17 USP17L6P USP17L3 FHL2 USP17L22 USP17L15 USP17L8 USP17L13	6.68e-08	1226	114	21	MM979
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRAS1 RNF152 GPR21 MEI1 ATP10A FHL2	5.54e-06	179	110	6	820289f14ecf165758529c236bb220bb1a744f02
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRAS1 RNF152 GPR21 MEI1 ATP10A FHL2	5.54e-06	179	110	6	e5f781d35449628a7f356d71e26231dd63482eec
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	TMEM241 CRACR2A MEI1 FANCA ENTPD1 MED23	5.72e-06	180	110	6	551b8de8d933d11bcd3897aeb2fd033355f958e2
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TMEM241 CRACR2A FANCA TBC1D4 ENTPD1 MED23	6.29e-06	183	110	6	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 RNF152 NTN4 ENTPD1 TSHZ1 FHL2	9.04e-06	195	110	6	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 RNF152 NTN4 ENTPD1 TSHZ1 FHL2	9.04e-06	195	110	6	a486a7acea0e91048cc48afa0dbd3926d30bc217
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_ACKR1+_endothelial_cells\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ATP10A TBC1D4 CSF2RB ENTPD1 APLNR CPVL	9.58e-06	197	110	6	143607d195c8aa2b94d995af0b2ef38582565611
ToppCell	Bronchial_Biopsy-Endothelial-Endothelial\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	ZEB1 ZNF521 CSF2RB ENTPD1 APLNR AP1S2	9.86e-06	198	110	6	d4a4e5c358d26d09ff27541ce49d0db75c1cd08e
ToppCell	Bronchial_Biopsy-Endothelial\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	ZEB1 ZNF521 CSF2RB ENTPD1 APLNR AP1S2	9.86e-06	198	110	6	ec80b05b8a1800c341b5741bf3e57213308398a7
Drug	CV-1	PCSK5 FANCA AP2S1 FURIN SCNN1B BMPER CPVL THAP12	3.93e-06	213	98	8	CID000130105
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	9.31e-35	46	113	19	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 KMT2C USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	7.74e-33	69	113	20	DOID:1682 (implicated_via_orthology)
Disease	cold shock domain-containing protein E1 measurement	VTN ARHGEF3	4.35e-05	3	113	2	EFO_0802416
Disease	intersectin-1 measurement	VTN ARHGEF3	4.35e-05	3	113	2	EFO_0801733
Disease	calcium-binding and coiled-coil domain-containing protein 2 measurement	VTN ARHGEF3	8.68e-05	4	113	2	EFO_0802356
Disease	MAGUK p55 subfamily member 7 measurement	VTN ARHGEF3	8.68e-05	4	113	2	EFO_0802724
Disease	lysozyme-like protein 2 measurement	VTN ARHGEF3	1.44e-04	5	113	2	EFO_0801779
Disease	n-acetylserotonin O-methyltransferase-like protein measurement	VTN ARHGEF3	2.16e-04	6	113	2	EFO_0801818
Disease	thioredoxin domain-containing protein 5 measurement	UTS2R ARHGEF3	2.16e-04	6	113	2	EFO_0802128
Disease	ribonucleoside-diphosphate reductase subunit M2 B measurement	VTN ARHGEF3	3.01e-04	7	113	2	EFO_0802022
Disease	dynein light chain roadblock-type 1 measurement	VTN ARHGEF3	4.01e-04	8	113	2	EFO_0008114
Disease	CXCL1 measurement	VTN CRACR2A	5.14e-04	9	113	2	EFO_0010777
Disease	non-receptor tyrosine-protein kinase TYK2 measurement	VTN ARHGEF3	6.41e-04	10	113	2	EFO_0008251
Disease	f-box/LRR-repeat protein 4 measurement	PCIF1 ARHGEF3	6.41e-04	10	113	2	EFO_0802538
Disease	renal fibrosis (implicated_via_orthology)	GPR21 GPR52	1.90e-03	17	113	2	DOID:0050855 (implicated_via_orthology)
Disease	urate measurement, bone density	FRAS1 PLB1 CRACR2A FANCA RANBP17 SLC26A8 CSF2RB DNAH9	2.67e-03	619	113	8	EFO_0003923, EFO_0004531

Protein segments in the cluster

Peptide	Gene	Start	Entry
KACLNSTYEYIFNNC	UNC13A	1001	Q9UPW8
CYPFSYSDCQELLNQ	AGBL5	156	Q8NDL9
PCLSSYDSYCSNQVA	ARHGEF3	206	Q9NR81
NVYCCFRSSTYVQVL	CTC1	981	Q2NKJ3
CLAAIYSCYEEFINS	CMIP	331	Q8IY22
LFNYYLTTCLQSSVN	ABHD3	266	Q8WU67
IYAICSDYAFLNQAT	BIVM	66	Q86UB2
LATENNLIFYECSAY	CRACR2A	676	Q9BSW2
TSFYFYNCSSLNQTC	ERVV-2	111	B6SEH9
FFTVALIYNASCATC	ATP10A	1241	O60312
YFCICVDVNDNNLAY	AP2S1	66	P53680
CYENDYPSLSSQNTC	RAD51AP2	326	Q09MP3
SSCCTSLDYIVTYLF	RANBP17	931	Q9H2T7
FPYCTCISYVNSCLN	APLNR	291	P35414
CISYVNSCLNPFLYA	APLNR	296	P35414
YASLYFCCAIEDQDN	AP1S2	61	P56377
SCAPQYYLDFSTNTC	FRAS1	941	Q86XX4
VFCSNNCFILYSSTA	KMT2C	4236	Q8NEZ4
ATACYLPADRCNYQT	LRP10	371	Q7Z4F1
KSNFQSYSCVRCNYT	IL17RB	91	Q9NRM6
SYSCVRCNYTEAFQT	IL17RB	96	Q9NRM6
TISCLQSEDFATYYC	IGKV1D-8	96	A0A087WSZ0
VTSYLLAYFNSCLNA	MTNR1B	291	P49286
QNVTGCSNYYNFLRC	CPVL	306	Q9H3G5
TSFYFYNCSSLNQTC	ERVV-1	111	B6SEH8
SCKYGYFLNEETNSC	PCSK5	706	Q92824
VISSLCCSNFVYFYT	SLC25A17	71	O43808
CCSNFVYFYTFNSLK	SLC25A17	76	O43808
LAYLSFIDACYSSVN	OR4C46	61	A6NHA9
RTSESDCYCYNQNSQ	NEMP2	46	A6NFY4
LLCNAYSTNSECFTL	MED23	476	Q9ULK4
HFTYNLYCNICRSLF	DNAH12	2326	Q6ZR08
LSSQYDYSEDFLCDC	LCA5L	61	O95447
ACYAALFCLSASIIY	MYADM	106	Q96S97
YDPAANECYCASLSN	KLHL40	331	Q2TBA0
LAYLSFIDACYSSVN	OR4C13	61	Q8NGP0
ELFNTSYCPYSQCAF	ENTPD1	331	P49961
VSYCSSNIINHFYCD	OR8J3	166	Q8NGG0
AISNSFCNCVIYSLS	GPR52	306	Q9Y2T5
FCNCVIYSLSNSVFR	GPR52	311	Q9Y2T5
YANYSCIASVRNVCN	MDGA2	211	Q7Z553
SFCSNSQVAFRDACY	PKD1L2	26	Q7Z442
CSNFLYYMCLNLLSA	MEI1	626	Q5TIA1
YPQAIYTLCSSCALN	THAP12	351	O43422
PSCYEDYQNTSSFDC	PCF11	1476	O94913
VSYCSSNIINHFYCD	OR8J2	166	Q8NGG1
SLYDCCINSLLQYFQ	NPC1L1	481	Q9UHC9
VSYCSSNIINHFYCD	OR8J1	166	Q8NGP2
SSCFECTHYQSFLEY	COMT	236	P21964
NCCYLNAAVSAFFDR	HSPBAP1	321	Q96EW2
QTLRCYNDYTSHITC	CSF2RB	31	P32927
NCYCESFLAYTRACQ	BMPER	596	Q8N8U9
LNCYFRQYCSAFPDT	PCIF1	516	Q9H4Z3
AQYSCFSSATTSICY	COLCA2	91	A8K830
DSCNCDGYTNSIYTL	FURIN	301	P09958
SLYSTYCQACSAAEE	FANCA	616	O15360
QLLCTDCYSNEYSSK	FHL2	86	Q14192
LCFSCSSQRNRSNYY	CLDN2	181	P57739
STYHNCLECSGNYTA	INPP5B	901	P32019
SCLQSEDFATYYCQQ	IGKV1-8	96	A0A0C4DH67
LEQFSEKFYCSCYST	SPAM1	426	P38567
CFANICDAQFLYSYE	DNAH9	1821	Q9NYC9
NSFCNCVIYSLSNSV	GPR21	296	Q99679
LAYSALCNTAATLSY	DNAJC22	196	Q8N4W6
YAVTDFLTYNCLTND	DHX34	1041	Q14147
FLTYNCLTNDTDLYS	DHX34	1046	Q14147
DYNTTYSIQACLRSC	SCNN1B	376	P51168
CTYYATQKQNEFTCA	PANX2	246	Q96RD6
TSYESCNITSYDNLF	INVS	241	Q9Y283
TKCTSDSYYQDNCAN	JAG1	946	P78504
FFLCNLSFLDVCYTS	OR13C8	61	Q8NGS7
EYCTYVVCNATNSSL	SYDE2	336	Q5VT97
QTYSLVCDAYCSLFN	PARS2	221	Q7L3T8
DCLPSICFYTFLNAY	TAF5	456	Q15542
TASSNLNCYYYESRC	TRIM42	81	Q8IWZ5
DINASAYSAYACLAI	SIDT2	601	Q8NBJ9
QDSLLECQICFNYYS	RNF152	6	Q8N8N0
TTCGQNATELYCFYS	NTN4	51	Q9HB63
FQCCSSITFVNVYYL	SLC26A8	556	Q96RN1
SRTCDQNTYLSGLCY	ITGAL	116	P20701
DLCDYCTDSNLYSAA	PLB1	861	Q6P1J6
GNTCYENASLQCLTY	USP17L3	86	A6NCW0
SFCENYNEYCTLTQD	RNASE13	91	Q5GAN3
QCGKAFSCSCYTQLY	ZNF441	256	Q8N8Z8
ECYNLCSQYLTTSHN	ZNF519	96	Q8TB69
GNTCYENASLQCLTY	USP17L4	86	A6NCW7
LNYCRSFCQTLLQYA	RLF	71	Q13129
QLCGNEYYSSFCCAS	PAPLN	1251	O95428
EYYSSFCCASCSRFQ	PAPLN	1256	O95428
ENFLALCASNYYNGC	PPIL3	26	Q9H2H8
STYYICESCDKQFTS	ZNF521	691	Q96K83
GNTCYVNASLQCLTY	USP17L18	86	D6R9N7
NTCYCNSVLQALYFC	USP12	46	O75317
GNTCYVNASLQCLTY	USP17L5	86	A8MUK1
IVTSYSNYCEDSFCN	TEX101	101	Q9BY14
SYSSDFRQIFCQACL	UBR1	326	Q8IWV7
GNTCYVNASLQCLTY	USP17L21	86	D6R901
GNTCYVNASLQCLTY	USP17L13	86	C9JLJ4
TTLYQQDYDFCTAIC	TSPAN31	136	Q12999
GNTCYVNASLQCLTY	USP17L19	86	D6RCP7
ACLNSTYEYIFNNCH	UNC13B	926	O14795
GNTCYENASLQCLTY	USP17L1	86	Q7RTZ2
SQYICYVFQCASESL	TBC1D4	411	O60343
YRCNECGKTFSQTYS	ZNF813	271	Q6ZN06
NEDNFSCSLCSYTFA	ZEB1	196	P37275
SCSLCSYTFAYRTQL	ZEB1	201	P37275
TFCTCYLASYLTNKY	TMEM241	11	Q24JQ0
GNTCYVNASLQCLTY	USP17L12	86	C9JPN9
VNYLTTCLTYGNSCA	UTS2R	296	Q9UKP6
GNTCYCNSVLQALYF	USP46	41	P62068
GNTCYVNASLQCLTY	USP17L24	86	Q0WX57
VYQCEYCEYSTTDAS	ZFX	746	P17010
GNTCYLNASLQCLTY	USP17L8	86	P0C7I0
GNTCYVNASLQCLTY	USP17L6P	86	Q6QN14
NVCFSSSQYSICFTL	EFTUD2	306	Q15029
CTLDSALNAASYYNF	TCTN3	266	Q6NUS6
GNTCYVNASLQCLTY	USP17L22	86	D6RA61
GNTCYVNASLQCLTY	USP17L15	86	C9J2P7
GNTCYVNASLQCLTY	USP17L17	86	D6RBQ6
DELCSYYQSCCTDYT	VTN	41	P04004
GNTCYVNASLQCLTY	USP17L23	86	D6RBM5
FCNDCASQFRTASTY	TSHZ1	971	Q6ZSZ6
GNTCYENASLQCLTY	USP17L2	86	Q6R6M4
GNTCYVNASLQCLTY	USP17L20	86	D6RJB6
MAYCLTNCYQYSVTF	ZNF560	1	Q96MR9
GNTCYVNASLQCLTY	USP17L10	86	C9JJH3
GNTCYVNASLQCLTY	USP17L11	86	C9JVI0