Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-21 ERVK-9 ERVK-19 ERVK-25 ERVK-24 ERVK-8

6.78e-08371987GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-21 ERVK-9 ERVK-19 ERVK-25 ERVK-24 ERVK-8

8.25e-08381987GO:0070001
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN8A ATP1A1

1.70e-07141985GO:0031402
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN8A ATP1A1

5.06e-06261985GO:0031420
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

TRPM4 SCN1A SCN2A SCN3A SCN8A GRIK1 SLC6A5 SLC4A10 SLC5A8 ATP1A1

8.28e-0617119810GO:0015081
GeneOntologyMolecularFunctionsodium channel activity

TRPM4 SCN1A SCN2A SCN3A SCN8A GRIK1

1.23e-05521986GO:0005272
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-6 EPPK1 RPLP0 RPLP0P6 OBSCN ERVK-21 ERVK-9 NEB PNPLA1 ERVK-19 SRPX ERVK-25 ERVK-24 IMPG2 ANK3 CILP PCLO LAMA4 LAMA5 ARPC1B ERVK-8 MACF1 EPB41L2

2.69e-0589119823GO:0005198
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPM4 RYR2 ITPR3 SCN1A SCN2A SCN3A SCN8A CACNA1E HTR1B GRIK1 SLC6A5 SLC4A10 SLC5A8 ATP1A1 CACNA2D3

6.56e-0546519815GO:0046873
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN8A

1.18e-04261984GO:0005248
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ERVK-6 ENPP2 LYPLA2 INPP5D TATDN2 PNPLA1 PNPLA6 AGO3 FIG4 PTPRS PLA2G6 SMPD3 PLCZ1 CILP RPP30 NDST2 PTPRU SND1 ERVK-8 ATP1A1

1.60e-0480719820GO:0016788
GeneOntologyMolecularFunctionlysophospholipase activity

ENPP2 LYPLA2 PNPLA6 PLA2G6

1.83e-04291984GO:0004622
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPM4 RYR2 ITPR3 GRIK1

2.39e-04311984GO:0099604
GeneOntologyMolecularFunctioncalcium channel activity

TRPM4 RYR2 ITPR3 CACNA1E HTR1B GRIK1 CACNA2D3

3.06e-041291987GO:0005262
GeneOntologyMolecularFunctionlipase activity

ENPP2 LYPLA2 PNPLA1 PNPLA6 PLA2G6 SMPD3 PLCZ1

4.60e-041381987GO:0016298
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 AGO3 RPP30 ERVK-8

4.79e-04371984GO:0016891
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPM4 RYR2 ITPR3 SCN1A SCN2A SCN3A SCN8A CACNA1E HTR1B GRIK1 CACNA2D3

6.55e-0434319811GO:0005261
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPM4 RYR2 ITPR3 CACNA1E HTR1B GRIK1 CACNA2D3

7.86e-041511987GO:0015085
GeneOntologyMolecularFunctionphospholipase activity

ENPP2 LYPLA2 PNPLA6 PLA2G6 SMPD3 PLCZ1

9.68e-041141986GO:0004620
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 AGO3 RPP30 ERVK-8

1.11e-03461984GO:0016893
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 AGO3 RPP30 SND1 ERVK-8

1.13e-03791985GO:0004521
GeneOntologyMolecularFunctionendopeptidase activity

PCSK5 ERVK-6 ERVK-21 ERVK-9 ADAMTS15 ERVK-19 ERVK-25 ERVK-24 MMEL1 ERVK-8 SENP2 CTRL

1.26e-0343019812GO:0004175
GeneOntologyMolecularFunctionphosphatidylinositol binding

SNX3 OBSCN ITPR3 SNX30 ARAP1 ARAP2 TECPR1 PLCZ1 APBA1 PITPNM1

1.27e-0331619810GO:0035091
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate binding

SNX3 OBSCN TECPR1 PLCZ1

1.30e-03481984GO:0032266
GeneOntologyMolecularFunctionphosphatidylinositol-5-phosphate binding

SNX3 OBSCN PLCZ1

1.47e-03231983GO:0010314
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TRPM4 RYR2 ITPR3 SCN1A SCN2A SCN3A SCN8A CACNA1E HTR1B GRIK1 SLC6A5 SLC4A10 SLC5A8 ATP1A1 CACNA2D3

1.52e-0362719815GO:0022890
GeneOntologyBiologicalProcessmembrane depolarization during action potential

TRPM4 SCN1A SCN2A SCN3A SCN8A ANK3

1.11e-06361986GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential

TRPM4 RYR2 SCN1A SCN2A SCN3A SCN8A ANK3 ATP1A1

1.91e-06871988GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

TRPM4 RYR2 SCN1A SCN2A SCN3A SCN8A ATP1A1

2.13e-06621987GO:0086002
GeneOntologyBiologicalProcesssodium ion transport

TRPM4 PER1 ADRB2 SCN1A SCN2A SCN3A SCN8A ANK3 GRIK1 SLC6A5 SLC4A10 SLC5A8 ATP1A1

2.73e-0627519813GO:0006814
GeneOntologyBiologicalProcessbehavioral response to pain

SCN3A CACNA1E NTRK1 GRIK1 MTOR

1.26e-05321985GO:0048266
GeneOntologyBiologicalProcesstransmission of nerve impulse

NFASC SCN1A SCN2A SCN3A SCN8A CACNA1E ANK3 MTOR

1.27e-051121988GO:0019226
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-6 ERVK-21 ERVK-9 ADAMTS15 ERVK-19 CDON ERVK-8

1.77e-05851987GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-6 ERVK-21 ERVK-9 ADAMTS15 ERVK-19 CDON ERVK-8

1.77e-05851987GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-6 ERVK-21 ERVK-9 ADAMTS15 ERVK-19 CDON ERVK-8

2.39e-05891987GO:0006949
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN3A SCN8A ANK3 MTOR

3.13e-05631986GO:0019228
GeneOntologyBiologicalProcesscardiac muscle cell contraction

TRPM4 RYR2 SCN1A SCN2A SCN3A SCN8A ATP1A1

3.19e-05931987GO:0086003
GeneOntologyBiologicalProcesssodium ion transmembrane transport

TRPM4 SCN1A SCN2A SCN3A SCN8A ANK3 GRIK1 SLC6A5 SLC4A10 ATP1A1

3.43e-0520819810GO:0035725
GeneOntologyBiologicalProcesspolysaccharide biosynthetic process

NFKB1 UGP2 C1QTNF2 SMPD3 NDST2 MTOR

9.07e-05761986GO:0000271
GeneOntologyBiologicalProcessresponse to pain

SCN3A CACNA1E NTRK1 GRIK1 MTOR

1.27e-04511985GO:0048265
GeneOntologyBiologicalProcessaction potential

TRPM4 RYR2 SCN1A SCN2A SCN3A SCN8A ANK3 MTOR ATP1A1

1.46e-042011989GO:0001508
GeneOntologyBiologicalProcessmembrane depolarization

TRPM4 SCN1A SCN2A SCN3A SCN8A ANK3 GRIK1

1.69e-041211987GO:0051899
GeneOntologyBiologicalProcesscardiac muscle contraction

TRPM4 RYR2 SCN1A SCN2A SCN3A SCN8A MTOR ATP1A1

2.16e-041671988GO:0060048
GeneOntologyBiologicalProcesspolysaccharide metabolic process

PCDH12 NFKB1 UGP2 C1QTNF2 SMPD3 NDST2 MTOR

2.18e-041261987GO:0005976
GeneOntologyBiologicalProcessactin-mediated cell contraction

TRPM4 RYR2 SCN1A SCN2A SCN3A SCN8A ATP1A1

2.29e-041271987GO:0070252
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission, glutamatergic

PLA2G6 HTR1B GRIK1

2.32e-04131983GO:0051967
GeneOntologyBiologicalProcessstriated muscle contraction

TRPM4 RYR2 ADRB2 SCN1A SCN2A SCN3A SCN8A MTOR ATP1A1

2.58e-042171989GO:0006941
GeneOntologyCellularComponentsodium channel complex

TRPM4 SCN1A SCN2A SCN3A SCN8A GRIK1

2.42e-07291956GO:0034706
GeneOntologyCellularComponentnode of Ranvier

NFASC SCN1A SCN2A SCN8A ANK3

9.28e-07201955GO:0033268
GeneOntologyCellularComponentaxon initial segment

NFASC SCN1A SCN2A SCN8A ANK3

6.64e-06291955GO:0043194
GeneOntologyCellularComponentpresynaptic membrane

PTPRS SCN1A SCN2A SCN8A CACNA1E IL31RA HTR1B APBA1 GRIK1 SNCAIP SLC6A5 CACNA2D3

1.20e-0527719512GO:0042734
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN8A

1.59e-05171954GO:0001518
GeneOntologyCellularComponentsomatodendritic compartment

PCSK5 TRPM4 RPLP0 NFASC PTK7 ITPR3 AURKA ADRB2 PTPRS SCN1A SCN3A SCN8A DYNC1H1 CACNA1E DIP2B RAP1GAP HTR1B ANK3 NTRK1 PCLO APBA1 GRIK1 GRM5 SNCAIP MTOR SLC4A10 SKOR1

2.97e-05122819527GO:0036477
GeneOntologyCellularComponentneuronal cell body

PCSK5 TRPM4 PTK7 ITPR3 AURKA ADRB2 PTPRS SCN1A SCN3A SCN8A DYNC1H1 CACNA1E DIP2B RAP1GAP NTRK1 PCLO GRIK1 SNCAIP MTOR SLC4A10 SKOR1

3.72e-0583519521GO:0043025
GeneOntologyCellularComponentcell body

PCSK5 TRPM4 PTK7 ITPR3 AURKA ADRB2 PTPRS SCN1A SCN3A SCN8A DYNC1H1 CACNA1E DIP2B RAP1GAP NTRK1 PCLO GRIK1 PITPNM1 SNCAIP MTOR SLC4A10 SKOR1

5.90e-0592919522GO:0044297
GeneOntologyCellularComponentaxon

NFASC PTK7 AURKA ADRB2 PTPRS SCN1A SCN2A SCN3A SCN8A DYNC1H1 DYNC1I1 DIP2B RAP1GAP IL31RA HTR1B ANK3 NTRK1 PCLO GRIK1 SLC4A10 ATP1A1

9.36e-0589119521GO:0030424
GeneOntologyCellularComponentsynaptic membrane

ADRB2 PTPRS SCN1A SCN2A SCN8A CACNA1E IL31RA HTR1B ANK3 APBA1 GRIK1 GRM5 SNCAIP SLC6A5 AKAP1 CACNA2D3

1.21e-0458319516GO:0097060
GeneOntologyCellularComponentcell-cell contact zone

OBSCN SCN1A SCN2A TJP2 ANK3 ATP1A1

2.51e-04941956GO:0044291
GeneOntologyCellularComponentmitochondrial electron transfer flavoprotein complex

ETFA ETFDH

2.58e-0431952GO:0017133
GeneOntologyCellularComponentelectron transfer flavoprotein complex

ETFA ETFDH

2.58e-0431952GO:0045251
GeneOntologyCellularComponentcation channel complex

TRPM4 RYR2 SCN1A SCN2A SCN3A SCN8A CACNA1E GRIK1 CACNA2D3

3.76e-042351959GO:0034703
GeneOntologyCellularComponentintercalated disc

OBSCN SCN1A SCN2A ANK3 ATP1A1

4.34e-04681955GO:0014704
GeneOntologyCellularComponentcell-cell junction

EPPK1 PDLIM7 OBSCN FRS2 NFASC PCDH12 PTK7 SCN1A SCN2A TJP2 ANK3 PTPRU LLGL2 PAK2 ATP1A1

4.53e-0459119515GO:0005911
GeneOntologyCellularComponentparanode region of axon

NFASC SCN2A ANK3

4.94e-04171953GO:0033270
GeneOntologyCellularComponentZ disc

PDLIM7 OBSCN NEB RYR2 SCN1A SCN8A ANK3

5.49e-041511957GO:0030018
GeneOntologyCellularComponentanchoring junction

EPPK1 RPLP0 CDHR2 PDLIM7 OBSCN FRS2 NFASC PCDH12 ITGB8 PTK7 SCN1A SCN2A TJP2 ANK3 PTPRU ARPC1B LLGL2 PAK2 ATP1A1 EPB41L2

8.29e-0497619520GO:0070161
GeneOntologyCellularComponentpostsynaptic specialization

RPLP0 AURKA PTPRS SCN8A ANK3 PCLO GRIK1 GRM5 INSYN2A PAK2 MACF1 ATP1A1 AKAP1

9.20e-0450319513GO:0099572
GeneOntologyCellularComponentI band

PDLIM7 OBSCN NEB RYR2 SCN1A SCN8A ANK3

9.61e-041661957GO:0031674
GeneOntologyCellularComponentpostsynaptic density

RPLP0 AURKA PTPRS SCN8A ANK3 PCLO GRIK1 GRM5 INSYN2A PAK2 MACF1 ATP1A1

1.13e-0345119512GO:0014069
GeneOntologyCellularComponentGolgi stack

PCSK5 LYPLA2 YIPF1 SMPD3 ARAP1 ST3GAL2 PITPNM1

1.14e-031711957GO:0005795
GeneOntologyCellularComponentdendrite

PCSK5 RPLP0 NFASC ITPR3 ADRB2 SCN8A DIP2B RAP1GAP HTR1B ANK3 NTRK1 PCLO APBA1 GRIK1 GRM5 MTOR SLC4A10 SKOR1

1.16e-0385819518GO:0030425
GeneOntologyCellularComponentdendritic tree

PCSK5 RPLP0 NFASC ITPR3 ADRB2 SCN8A DIP2B RAP1GAP HTR1B ANK3 NTRK1 PCLO APBA1 GRIK1 GRM5 MTOR SLC4A10 SKOR1

1.20e-0386019518GO:0097447
GeneOntologyCellularComponentmain axon

NFASC SCN1A SCN2A SCN8A ANK3

1.48e-03891955GO:0044304
GeneOntologyCellularComponentlate endosome membrane

HLA-DQB1 YIPF1 FIG4 BAIAP3 NTRK1 VPS41 LAMP3

1.49e-031791957GO:0031902
GeneOntologyCellularComponentGolgi cisterna

PCSK5 YIPF1 SMPD3 ARAP1 ST3GAL2 PITPNM1

1.69e-031351956GO:0031985
GeneOntologyCellularComponentasymmetric synapse

RPLP0 AURKA PTPRS SCN8A ANK3 PCLO GRIK1 GRM5 INSYN2A PAK2 MACF1 ATP1A1

1.80e-0347719512GO:0032279
GeneOntologyCellularComponentsarcolemma

OBSCN RYR2 ADRB2 SCN1A SCN2A ANK3 ATP1A1

2.09e-031901957GO:0042383
GeneOntologyCellularComponentpronucleus

EZH2 AURKA PLCZ1

2.21e-03281953GO:0045120
HumanPhenoSudden unexpected death in epilepsy

WWOX FIG4 SCN1A SCN8A SHQ1

1.17e-0710725HP:0033258
HumanPhenoHypertonia

WWOX HLA-DQB1 NADK2 NFASC DAO PCDH12 EZH2 PRDM8 PNPLA6 FIG4 SCN1A SCN2A SCN3A SCN8A UGP2 PLA2G6 ASCC3 DYNC1H1 CDON CACNA1E ANK3 PCLO B3GALNT2 NSD1 TWNK CP SHQ1 SNCAIP VPS41 SLC6A5 SLC4A10 MACF1

2.87e-0511517232HP:0001276
HumanPhenoSpasticity

WWOX HLA-DQB1 NADK2 NFASC DAO PCDH12 EZH2 PRDM8 PNPLA6 FIG4 SCN1A SCN2A SCN3A SCN8A UGP2 PLA2G6 ASCC3 DYNC1H1 CDON CACNA1E ANK3 PCLO B3GALNT2 NSD1 TWNK CP SHQ1 SNCAIP VPS41 SLC6A5 SLC4A10 MACF1

2.87e-0511517232HP:0001257
HumanPhenoAggressive behavior

WWOX MANBA NFASC FIG4 SCN1A SCN2A SCN3A SCN8A PLA2G6 CDON FAT4 ANK3 NTRK1 NSD1 SHQ1 SLC4A10 DCHS1 ATP1A1 RAI1

6.39e-055167219HP:0000718
HumanPhenoAbnormal aggressive, impulsive or violent behavior

WWOX MANBA NFASC FIG4 SCN1A SCN2A SCN3A SCN8A PLA2G6 CDON FAT4 ANK3 NTRK1 NSD1 SHQ1 SLC4A10 DCHS1 ATP1A1 RAI1

6.39e-055167219HP:0006919
HumanPhenoPachygyria

ETFA ETFDH FIG4 SCN2A DYNC1H1 FAT4 B3GALNT2 MTOR DCHS1 MACF1

8.26e-051637210HP:0001302
MousePhenoabnormal nervous system electrophysiology

PER1 NFASC RYR2 FIG4 SCN1A NFKB1 SCN2A SCN8A DHTKD1 BAIAP3 ANK3 GRIK1 GRM5 GPR139 SENP2 RAI1

9.85e-0732915816MP:0002272
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN8A

1.50e-0761894PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN8A

1.50e-0761894IPR024583
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN8A

2.03e-06101894IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN8A

2.03e-06101894IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN8A

2.03e-06101894PF06512
DomainIon_trans_dom

TRPM4 RYR2 ITPR3 SCN1A SCN2A SCN3A SCN8A CACNA1E

2.09e-051141898IPR005821
DomainIon_trans

TRPM4 RYR2 ITPR3 SCN1A SCN2A SCN3A SCN8A CACNA1E

2.09e-051141898PF00520
DomainPatatin

PNPLA1 PNPLA6 PLA2G6

8.19e-0591893PF01734
DomainPNPLA

PNPLA1 PNPLA6 PLA2G6

8.19e-0591893PS51635
DomainPatatin/PLipase_A2-rel

PNPLA1 PNPLA6 PLA2G6

8.19e-0591893IPR002641
DomainIQ

OBSCN SCN1A SCN2A SCN3A SCN8A LRRIQ3

1.72e-04811896SM00015
DomainChannel_four-helix_dom

SCN1A SCN2A SCN3A SCN8A CACNA1E

2.75e-04571895IPR027359
Domain-

SCN1A SCN2A SCN3A SCN8A CACNA1E

2.75e-045718951.20.120.350
DomainIQ_motif_EF-hand-BS

OBSCN SCN1A SCN2A SCN3A SCN8A LRRIQ3

3.05e-04901896IPR000048
DomainIQ

OBSCN SCN1A SCN2A SCN3A SCN8A LRRIQ3

3.65e-04931896PS50096
PathwayWP_DRAVET_SYNDROME

SCN1A NFKB1 SCN2A SCN3A SCN8A MTOR

4.58e-07281536M45519
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

NFASC SCN1A SCN2A SCN3A SCN8A ANK3

8.72e-07311536M877
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

NEB SCN1A SCN2A SCN3A C5

6.13e-12520151679748
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 TRPM4 EPPK1 OBSCN PER1 TBC1D9 ITPR3 SNX30 PNPLA6 PTPRS UCKL1 SCN8A PLA2G6 DYNC1H1 ARAP1 DIRAS1 NSD1 LAMA5 TWNK THADA LLGL2 GAREM2 SND1 MTOR TTLL4 SENP2 RAI1

3.05e-1011052012735748872
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A SCN8A

1.08e-094201417537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A SCN8A

1.08e-094201435031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A SCN8A

1.08e-094201429578003
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A SCN8A ANK3

4.70e-0912201530175250
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-21 ERVK-9 ERVK-19 ERVK-8

4.70e-0912201514557543
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

NEB SCN1A SCN2A SCN3A

5.39e-09520148812438
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN8A

1.61e-086201423652591
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RPLP0 NFASC PIK3R4 FARSA PNPLA6 PTPRS PURB SCN2A UGP2 TJP2 USP4 HSPA4 DYNC1H1 DYNC1I1 RAP1GAP ANK3 HSPA4L PCLO GRM5 ARPC1B PITPNM1 SND1 KIAA1217 SLC4A10 MACF1 ATP1A1 EPB41L2 CACNA2D3

1.82e-0814312012837142655
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A SCN8A

1.33e-079201415746173
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN8A

1.33e-079201416382098
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

1.90e-073201312610651
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

1.90e-073201318784617
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

1.90e-073201328518218
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

1.90e-073201323859570
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

1.90e-073201317544618
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

1.90e-073201332845893
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

1.90e-073201317928448
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

1.90e-073201314973256
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

ANO9 WWOX OBSCN MAP3K3 AURKA MEST ANLN PURB NFRKB TJP2 BAIAP3 P4HA2 ANK3 RCCD1 NSD1 ST3GAL2 TMEFF1 RASSF1 TTLL4 CSTF2 MACF1 LRRC71

3.76e-0710842012211544199
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN8A

7.43e-0713201415123669
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

7.57e-074201335801810
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

7.57e-074201321156207
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

7.57e-07420138974318
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-21 ERVK-9 ERVK-19 ERVK-25 ERVK-24 ERVK-8

1.30e-0694201721542922
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A HTR1B

1.41e-061520149726281
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

EPPK1 RPLP0 ITPR3 TJP2 NOC4L ASCC3 HSPA4 DYNC1H1 DCAF13 NSD1 SND1 MTOR MACF1 ATP1A1 EPB41L2 RAI1

1.48e-066532011622586326
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

1.89e-065201324337656
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN8A

1.89e-065201317724025
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-21 ERVK-19

1.89e-065201312629516
Pubmed

Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.

SCN3A HSPA4 DYNC1H1 MACF1

2.43e-0617201420395553
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 SNX3 MCMBP PATZ1 MAP3K3 PIK3R4 ANLN TJP2 ARAP2 DIP2B RAP1GAP IKBKE MTOR KIAA1217 MACF1 MPHOSPH9 AKAP1 EPB41L2

3.03e-068612011836931259
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-25 ERVK-24

3.11e-0618201418664271
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

PATZ1 NFASC FARSA AGO3 PTPRS PURB DYNC1H1 CACNA1E DIP2B ANK3 NSD1 GRM5 MTOR KIAA1217 DCHS1 PAK2 MACF1 EPB41L2 RAI1

3.68e-069632011928671696
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-9 ERVK-19

3.76e-066201315063128
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

WWOX RPLP0 FRS2 AURKA FARSA ASCC3 HSPA4 DYNC1H1 ANK3 HSPA4L SND1 PAK2 MACF1 MPHOSPH9 ATP1A1 EPB41L2

4.15e-067082011639231216
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TRPM4 WWOX OBSCN NFASC PTK6 PTK7 SNX30 PNPLA6 PTPRS UCKL1 PLA2G6 BAIAP3 ARAP1 DIP2B ANK3 B3GALNT2 GRIK1 RLF THADA KIAA1217 VPS41 GPR137B MACF1 RAI1

6.08e-0614892012428611215
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

DYNC1H1 DYNC1I1 CACNA1E ANK3 PCLO GRM5 PITPNM1 MTOR MACF1 EPB41L2

6.16e-062812011028706196
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A SCN8A

6.54e-067201325818041
Pubmed

PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.

MEST ARAP1 ARAP2

6.54e-067201320978237
Pubmed

Functional proteomics mapping of a human signaling pathway.

RPLP0 PDLIM7 BCAT1 RYR2 ASCC3 DYNC1H1 ANK3 LAMA4 LAMA5 TWNK RLF RNF123 VPS41 MACF1

9.98e-065912011415231748
Pubmed

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.

PNPLA1 PNPLA6 PLA2G6

1.56e-059201319029121
Pubmed

E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.

MCMBP INPP5D HSPA4 PAK2

1.99e-0528201430277474
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-21 ERVK-19

2.21e-0510201312970426
Pubmed

Characterization of the human patatin-like phospholipase family.

PNPLA1 PNPLA6 PLA2G6

2.21e-0510201316799181
Pubmed

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

ITPR3 IL31RA ERO1B NTRK1 THADA SLC5A8

2.48e-0599201619730683
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MCMBP OBSCN FRS2 NFASC SCN3A SCN8A ADAMTS15 DYNC1H1 DNAH3 FAT4 PCLO RNF123 CSTF2 EPB41L2 RAI1

2.78e-057362011529676528
Pubmed

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

FAT4 ANK3 PCLO

3.03e-0511201320351715
Pubmed

The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy.

NFKB1 MTOR

3.32e-052201233860440
Pubmed

Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.

NFKB1 IKBKE

3.32e-052201216299251
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

3.32e-052201237901435
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

3.32e-052201219694741
Pubmed

NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.

MAP3K3 NFKB1

3.32e-052201215047705
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

3.32e-052201215760941
Pubmed

Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes.

LAMA4 LAMA5

3.32e-052201218523231
Pubmed

Translation of Tudor-SN, a novel terminal oligo-pyrimidine (TOP) mRNA, is regulated by the mTORC1 pathway in cardiomyocytes.

SND1 MTOR

3.32e-052201233054526
Pubmed

Screening of integrin-binding peptides from the laminin α4 and α5 chain G domain peptide library.

LAMA4 LAMA5

3.32e-052201222391228
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

3.32e-052201223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

3.32e-052201227153334
Pubmed

Gene expression profiling of LPS-stimulated murine macrophages and role of the NF-kappaB and PI3K/mTOR signaling pathways.

NFKB1 MTOR

3.32e-052201217405917
Pubmed

Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.

RYR2 ITPR3

3.32e-052201218586264
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

3.32e-052201231943325
Pubmed

Peptides derived from the human laminin alpha4 and alpha5 chains exhibit antimicrobial activity.

LAMA4 LAMA5

3.32e-052201220433883
Pubmed

RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma.

AURKA MTOR

3.32e-052201225183163
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

3.32e-052201227690330
Pubmed

Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.

TET2 EZH2

3.32e-052201226773568
Pubmed

S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation.

EZH2 NFKB1

3.32e-052201226506125
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

3.32e-052201218601978
Pubmed

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.

LAMA4 LAMA5

3.32e-052201231343575
Pubmed

The NSD1 and EZH2 overgrowth genes, similarities and differences.

EZH2 NSD1

3.32e-052201223592277
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

3.32e-052201230693367
Pubmed

The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1.

DYNC1H1 DYNC1I1

3.32e-052201227210554
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

3.32e-052201229649454
Pubmed

Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance.

TET2 EZH2

3.32e-052201221339759
Pubmed

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.

ITPR3 GRM5

3.32e-052201222539775
Pubmed

An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.

PER1 PCLO

3.32e-052201211285225
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

3.32e-05220129060628
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

3.32e-052201233096315
Pubmed

New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A.

AURKA RASSF1

3.32e-052201230944388
Pubmed

Early events in node of Ranvier formation during myelination and remyelination in the PNS.

NFASC SCN2A

3.32e-052201216652168
Pubmed

Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.

LAMA4 LAMA5

3.32e-052201219396173
Pubmed

Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.

RYR2 ITPR3

3.32e-052201224285081
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

3.32e-052201217805013
Pubmed

NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants.

MANBA NFKB1

3.32e-052201230528300
Pubmed

Mapping of the gene coding for the muscle protein nebulin (Neb) to the proximal region of mouse chromosome 2.

NEB C5

3.32e-05220121683831
Pubmed

[Relationship between Pi-Wei damp-heat syndrome with expressions of nuclear factor-kappaB mRNA and heat shock protein 70 mRNA in patients with chronic gastritis].

NFKB1 HSPA4

3.32e-052201220353025
Pubmed

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma.

WWOX MTOR

3.32e-052201224008736
Pubmed

NF-κB1/IKKε Gene Expression and Clinical Activity in Patients With Rheumatoid Arthritis.

NFKB1 IKBKE

3.32e-052201229069487
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

3.32e-052201237665666
Pubmed

Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes.

SCN2A ANK3

3.32e-052201212036953
Pubmed

Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology.

NADK2 PLA2G6

3.32e-052201235796562
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

3.32e-052201217881658
Pubmed

Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.

NFASC ANK3

3.32e-052201229963618
Pubmed

Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.

SCN8A ANK3

3.32e-052201225874799
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

3.32e-052201220346423
Pubmed

Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function.

BCAT1 MTOR

3.32e-052201228235484
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

3.32e-052201226410685
Pubmed

Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B.

NFKB1 MTOR

3.32e-052201220299603
Pubmed

Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway.

SRPX MTOR

3.32e-052201221983129
InteractionCEACAM8 interactions

PCSK5 MANBA PTK7 PTPRS FAT4 SDK2 ERO1B LAMA5 CACNA2D3

1.93e-061191909int:CEACAM8
InteractionKCTD13 interactions

RPLP0 NFASC PIK3R4 FARSA ADRB2 PNPLA6 PTPRS PURB SCN2A UGP2 TJP2 USP4 SRPX HSPA4 DYNC1H1 DYNC1I1 RAP1GAP ANK3 HSPA4L PCLO TWNK GRM5 ARPC1B PITPNM1 SND1 KIAA1217 SLC4A10 MACF1 ATP1A1 EPB41L2 CACNA2D3

6.79e-06139419031int:KCTD13
InteractionEPM2A interactions

MCMBP PIK3R4 PRDM8 ANKMY2 HSPA4 HSPA4L

1.28e-05551906int:EPM2A
InteractionCCT3 interactions

ETFA ETFDH EZH2 MAP3K3 PTK6 PIK3R4 PNPLA1 AGO3 ANLN FNDC11 P4HA2 DCAF13 ANK3 NTRK1 RNF123 IKBKE ATP1A1 EPB41L2

1.75e-0560419018int:CCT3
InteractionCCT2 interactions

WWOX TATDN2 EZH2 PTK6 PIK3R4 PNPLA1 ANLN FNDC11 HSPA4 DYNC1I1 P4HA2 DCAF13 RCCD1 NTRK1 IKBKE MACF1 SENP2 ATP1A1 AKAP1

1.86e-0566619019int:CCT2
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN8A

3.22e-07913141203
GeneFamilyPatatin like phospholipase domain containing

PNPLA1 PNPLA6 PLA2G6

4.30e-05101313466
GeneFamilyFibronectin type III domain containing

OBSCN NFASC PTPRS CDON SDK2 IL31RA PTPRU

1.66e-041601317555
GeneFamilyCadherin related

CDHR2 FAT4 DCHS1

2.35e-0417131324
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

OBSCN NFASC PTK7 PTPRS CDON SDK2

1.14e-031611316593
GeneFamilyEF-hand domain containing|Plakins

EPPK1 MACF1

1.42e-0381312939
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

EZH2 PRDM8 NSD1

1.89e-03341313487
GeneFamilyAnkyrin repeat domain containing

NFKB1 ANKMY2 PLA2G6 ARAP1 ARAP2 ANK3 SNCAIP

1.93e-032421317403
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

BAIAP3 CCDC33 PCLO

2.23e-03361313823
GeneFamilyLaminin subunits

LAMA4 LAMA5

3.28e-03121312626
GeneFamilyDyneins, cytoplasmic

DYNC1H1 DYNC1I1

3.86e-03131312538
CoexpressionGSE32986_GMCSF_AND_CURDLAN_LOWDOSE_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_UP

INPP5D TBC1D9 GPR180 AURKA AGO3 UGP2 NDST2 NSD1 VPS41 MPHOSPH9

2.27e-0619919210M8639
CoexpressionGSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP

PDLIM7 HLA-DQB1 NFKB1 ERO1B GRIK1 CGGBP1 TTLL4 LAMP3 ATP1A1

1.45e-051951929M9527
CoexpressionGSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP

PDLIM7 PTK7 ITPR3 GPR180 SNX30 UCKL1 ANKMY2 DIRAS1 MPHOSPH9

1.78e-052001929M3526
CoexpressionGSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_MAC_UP

PCSK5 NFKB1 HSPA4 DYNC1I1 P4HA2 PCLO GRIK1 SLC6A5 GPR137B

1.78e-052001929M5247
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

TATDN2 NFASC NEB RYR2 TBC1D9 PRDM8 SCN1A SCN2A SCN3A SCN8A SMPD3 CDON CACNA1E DIP2B ANK3 PCLO APBA1 LAMA5 GRIK1 GRM5 INSYN2A RAI1

2.19e-05110619222M39071
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

BCAT1 SCN1A C5 ANK3 CP PTPRU IKBKE LAMP3 ATP1A1 AKAP1

1.68e-08197194101a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR2 SCN1A SCN2A SCN3A SCN8A DYNC1I1 PCLO GRM5 SLC4A10 CACNA2D3

1.77e-0819819410c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 SNX30 C5 ANK3 CP LAMP3 ATP1A1 AKAP1 CACNA2D3

9.65e-081791949fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN NEB RYR2 SORCS1 MELTF OTOGL SCN2A FAT4 PCLO

1.22e-0718419492cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN NEB RYR2 SORCS1 MELTF OTOGL SCN2A FAT4 PCLO

1.22e-0718419492b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN NEB RYR2 SORCS1 MELTF OTOGL SCN2A FAT4 PCLO

1.22e-071841949ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR2 SCN1A SCN2A SCN3A SCN8A DYNC1I1 PCLO GRM5 SLC4A10

2.27e-0719819496d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR2 SCN1A SCN2A SCN8A DYNC1I1 PCLO GRM5 SLC4A10 CACNA2D3

2.27e-0719819498ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR2 SCN1A SCN2A SCN3A SCN8A DYNC1I1 PCLO GRM5 SLC4A10

2.27e-0719819494ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR2 SCN2A SCN3A SCN8A DYNC1I1 ANK3 PCLO GRM5 SLC4A10

2.27e-0719819490ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

BCAT1 SNX30 C5 RAP1GAP ANK3 CP LAMP3 ATP1A1 AKAP1

2.48e-072001949e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

RYR2 SCN2A SCN3A SCN8A DYNC1I1 ANK3 PCLO GRM5 SLC4A10

2.48e-07200194948d801219bc771d6c7e151dc88ca4c179988de85
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 PTK7 PLCZ1 FAT4 SDK2 LAMA4 IKBKE KIAA1217

9.94e-071741948912a9e892b29d945666fc37c986009c97c668ac8
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGB8 PTK6 NKTR ANK3 KIAA1217 MACF1 SLC5A8 RAI1

1.23e-0617919486e965e424eebef50f0202cff75f458be395cfca1
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 SNX30 C5 ANK3 CP LAMP3 AKAP1 CACNA2D3

1.51e-061841948ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 SNX30 C5 ANK3 CP LAMP3 AKAP1 CACNA2D3

1.64e-061861948e83718fabb057100835d3357df407f283d23fe16
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 SNX30 C5 ANK3 CP LAMP3 AKAP1 CACNA2D3

1.78e-0618819484bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 SCEL C5 ANK3 CP LLGL2 LAMP3 CACNA2D3

1.78e-06188194843a0508d2524a5b310e89e9422843dcaab999bc3
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

RYR2 SCN2A SCN3A ANK3 PCLO GRM5 ATP1A1 CACNA2D3

1.92e-0619019486e92c78799f34b31d098854503c796edb0dc7f80
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM8 C1QTNF2 SRPX SMPD3 CDON CILP LAMA4 CP

2.08e-061921948d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NFASC PTPRS SRPX DYNC1I1 CDON LAMA4 CP EPB41L2

2.33e-0619519483c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR2 SCN2A SCN3A SCN8A DYNC1I1 PCLO GRM5 SLC4A10

2.42e-061961948676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellAT2_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

BCAT1 SCEL PTK7 ITPR3 RAP1GAP LAMP3 SLC5A8 ATP1A1

2.51e-06197194842e49a8ce3118db6c2fd620d70c480b75143c828
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BCAT1 SCN1A C5 ANK3 CP LAMP3 ATP1A1 AKAP1

2.51e-0619719481485933986921ff45669d9b7501c8d17050b3e97
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

ENPP2 ITGB8 RYR2 PTK7 FAT4 SDK2 ANK3 MACF1

2.51e-061971948f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BCAT1 C5 P4HA2 ANK3 CP LAMP3 ATP1A1 AKAP1

2.61e-061981948285f729140b1df029c24f6ca1d2438470ac51794
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

BCAT1 C5 RAP1GAP ANK3 CP LAMP3 ATP1A1 AKAP1

2.61e-061981948aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PCSK5 PDLIM7 PTK7 SORCS1 C1QTNF2 FAT4 LAMA4 SNCAIP

2.71e-06199194838cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SCEL ITPR3 SNX30 SCN1A RAP1GAP ANK3 LAMP3 SLC5A8

2.71e-061991948a38a981cffa61c8444a980916de7414e689a1b63
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MEST ADAMTS15 C1QTNF2 SRPX CDON FAT4 CILP LAMA4

2.71e-06199194895d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

RPLP0 RYR2 SORCS1 PRDM8 ANLN SCN2A ANK3 PCLO

2.71e-0619919481b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

RPLP0 RYR2 SORCS1 PRDM8 ANLN SCN2A ANK3 PCLO

2.71e-0619919484bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

NFASC RYR2 PTPRS FAT4 SDK2 LAMA4 MACF1 EPB41L2

2.81e-062001948aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

NFASC RYR2 PTPRS FAT4 SDK2 LAMA4 MACF1 EPB41L2

2.81e-062001948a510deaada669e690329183e18df02870bd204b3
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS1 SCN1A SCN2A SCN3A GRIK1 GRM5 KIAA1217 SLC4A10

2.81e-062001948961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ITGB8 TJP2 ANK3 PCLO LAMA5 LLGL2 KIAA1217 ATP1A1

2.81e-06200194897f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS1 SCN1A SCN2A SCN3A GRIK1 GRM5 KIAA1217 SLC4A10

2.81e-062001948f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS1 SCN1A SCN2A SCN3A GRIK1 GRM5 KIAA1217 SLC4A10

2.81e-062001948cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS1 SCN1A SCN2A SCN3A GRIK1 GRM5 KIAA1217 SLC4A10

2.81e-062001948c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS1 SCN1A SCN2A SCN3A GRIK1 GRM5 KIAA1217 SLC4A10

2.81e-0620019484fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS1 SCN1A SCN2A SCN3A GRIK1 GRM5 KIAA1217 SLC4A10

2.81e-062001948310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NFASC RYR2 PTPRS FAT4 SDK2 LAMA4 MACF1 EPB41L2

2.81e-062001948dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SNX3 HLA-DQB1 INPP5D SMPD3 ST3GAL2 LAMP3 GPR137B

8.46e-06166194763dc58864268b4e7779e4c45155022556fc634f9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DAO SORCS1 NLRP8 CACNA1E DNAH3 SDK2 SLC4A10

8.80e-0616719473edb0570e583bb527165bcd8a4c25a042054043b
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|myeloid / Lineage, cell class and subclass

ENPP2 PTK7 PTPRS SRPX SMPD3 INSYN2A SNCAIP

1.33e-051781947f75591988bbbeba073b66329a3437cb9b02f7648
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 PTK7 SORCS1 SDK2 IL31RA PTPRU KIAA1217

1.38e-0517919477954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 C5 ANK3 CP LAMP3 AKAP1 CACNA2D3

1.43e-051801947b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

CDHR2 SORCS1 DMGDH CACNA1E HSPA4L PCLO SLC5A8

1.48e-0518119476980ea624151da32b7f537f263e40fcb87a02e81
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 C5 P4HA2 ANK3 LAMP3 AKAP1 CACNA2D3

1.54e-051821947d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 C5 ANK3 CP LAMP3 AKAP1 CACNA2D3

1.54e-05182194717ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 C5 ANK3 CP LAMP3 AKAP1 CACNA2D3

1.59e-051831947e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 C5 ANK3 CP LAMP3 AKAP1 CACNA2D3

1.65e-051841947d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MELTF PTPRS ADAMTS15 SRPX CDON CILP CACNA2D3

1.71e-0518519479faa35ceb89ccd2979072286f063687c9f846ce3
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 C5 CDON ANK3 CP LAMP3 CACNA2D3

1.71e-0518519470d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 ENPP2 ETFDH ADRB2 PNPLA1 SRPX CP

1.71e-051851947b57dae20c21f984edd2acee4344d86f033108ebf
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

PCSK5 PDLIM7 ENPP2 TJP2 C1QTNF2 DYNC1I1 CACNA2D3

1.71e-051851947427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 ENPP2 ETFDH ADRB2 PNPLA1 SRPX CP

1.71e-051851947d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 SCEL C5 SDK2 CP LLGL2 CACNA2D3

1.77e-0518619474e94158db52df41d71e67b02b9895a358eebee0f
ToppCellLPS-antiTNF-Epithelial_alveolar|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 C5 ANK3 CP LLGL2 LAMP3 CACNA2D3

1.83e-051871947201ff693e4756ee3e44762885b3a303a77eb535b
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCAT1 SCEL C5 SDK2 CP LLGL2 CACNA2D3

1.83e-05187194758d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 CDHR2 ENPP2 SORCS1 HSPA4 HSPA4L SLC5A8

1.83e-051871947acd305475f3609800af0d7bc68d83ef41228080b
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FCHO1 SORCS1 OTOGL SMPD3 CDON LAMA5 CACNA2D3

1.83e-0518719478e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ITPR3 SNX30 SCN1A RAP1GAP ANK3 LAMP3 ATP1A1

1.83e-0518719475df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SORCS1 SCN2A SCN3A SCN8A SMPD3 BAIAP3 PCLO

1.89e-051881947c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

NFKB1 NKTR DYNC1H1 ARAP2 ERO1B RLF MACF1

1.89e-051881947ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCelldroplet-Liver-nan-3m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PATZ1 INPP5D CCL24 RBM45 APBA1 ST3GAL2

1.99e-05127194639fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 ENPP2 SORCS1 DYNC1I1 LAMA4 FREM3 CACNA2D3

2.03e-051901947c7bd087f36321cec61b98657433b4d19d135791f
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

HLA-DQB1 ENPP2 PTK7 PTPRS SRPX SMPD3 SDK2

2.03e-051901947dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 ENPP2 SORCS1 DYNC1I1 LAMA4 FREM3 CACNA2D3

2.03e-051901947834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellsevere-unassigned|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NFASC NEB EZH2 TJP2 CACNA1E KRBOX4

2.09e-051281946bef9cf0078fa8498d63f0723f1fa4a3c92405e10
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic|lymph-node_spleen / Manually curated celltypes from each tissue

HLA-DQB1 ENPP2 PTPRS SRPX SMPD3 INSYN2A LAMP3

2.10e-051911947c3ff4342e0eea1e1f071b1fbca14a6dd4df0c696
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTK7 SCN3A ADAMTS15 C1QTNF2 SRPX LAMA4 CP

2.10e-051911947ce80f65bd24b1c4d2152bf45248449e7a1a97e56
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 ENPP2 SORCS1 DYNC1I1 LAMA4 FREM3 CACNA2D3

2.10e-0519119479d3fa8d8138700640cc7927521c7635299df697d
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 ENPP2 SORCS1 DYNC1I1 LAMA4 FREM3 CACNA2D3

2.10e-051911947d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCN3A ADAMTS15 C1QTNF2 SRPX LAMA4 CP MACF1

2.10e-051911947094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCelldroplet-Lung-1m-Mesenchymal|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTK7 SCN3A ADAMTS15 C1QTNF2 SRPX LAMA4 CP

2.17e-05192194701433bd4794b8bcc51fe4249124a0f4289b9d6e2
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM8 C1QTNF2 SRPX SMPD3 CDON CILP CP

2.17e-051921947853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITPR3 SNX30 SCN1A RAP1GAP ANK3 PCLO LAMP3

2.17e-051921947cc9911e182a289779a2612bc213daae5607689e7
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

SNX30 SCN1A RAP1GAP ANK3 PCLO LAMP3 SLC5A8

2.17e-05192194706013a07e3a873b1d1c0451643c528593ac32a9c
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM8 C1QTNF2 SRPX SMPD3 CDON CILP CP

2.17e-05192194749281626ecad0456fdbded2378b7028d7b589686
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 SCN1A SCN2A SCN8A CACNA1E PCLO GRM5

2.24e-0519319478689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 ENPP2 SORCS1 DYNC1I1 LAMA4 FREM3 CACNA2D3

2.24e-0519319472b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 SCN1A SCN2A SCN8A CACNA1E PCLO GRM5

2.24e-051931947be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANO9 ITGB8 NKTR ARAP2 ANK3 SNCAIP MACF1

2.24e-0519319479337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NFASC RYR2 PTPRS ADAMTS15 SDK2 LAMA4 MACF1

2.24e-051931947b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 SCN1A SCN2A SCN8A CACNA1E PCLO GRM5

2.24e-0519319470c652ebe22ce5d2927599dd97ef1920547858395
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 ENPP2 SORCS1 DYNC1I1 LAMA4 FREM3 CACNA2D3

2.24e-05193194790cfc34c2d0d7c70f071703d35db1d6037961481
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

PURB SCN2A SCN8A DYNC1I1 DIRAS1 PCLO GRM5

2.32e-0519419478aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGB8 DMGDH ANK3 PCLO LLGL2 ATP1A1 CACNA2D3

2.32e-05194194793c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRS SRPX DYNC1I1 CDON LAMA4 CP EPB41L2

2.32e-051941947c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ENPP2 PTK7 MEST DYNC1I1 FAT4 LAMA4 MACF1

2.40e-0519519471cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WWOX ITGB8 ANK3 PCLO LLGL2 ATP1A1 CACNA2D3

2.40e-0519519476477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKTR ASCC3 DYNC1H1 ERO1B PCLO NSD1 MACF1

2.40e-0519519473e519cffa6144a62b06124642a14c9ff39b76554
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ENPP2 MEST DYNC1I1 FAT4 LAMA4 MACF1 EPB41L2

2.48e-0519619471450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BCAT1 SCEL C5 ANK3 CP LLGL2 ATP1A1

2.56e-0519719473d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDLIM7 NFASC RYR2 OTOGL HTR1B LAMA4 CACNA2D3

2.56e-051971947ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

ITGB8 RYR2 SORCS1 CILP LAMA4 IKBKE MACF1

2.64e-0519819470c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BCAT1 SCEL PLA2G6 CP PTPRU FREM3 LLGL2

2.64e-051981947b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BCAT1 SCEL C5 CP LLGL2 LAMP3 ATP1A1

2.64e-051981947f006d68e6c51923be7772eea118546a5762e8a5e
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BCAT1 SCEL C5 CP LLGL2 LAMP3 ATP1A1

2.64e-05198194750852713c017217c79777c95857097103bcf2fbe
DrugSodium

TRPM4 ADRB2 SCN2A SCN3A SCN8A CACNA1E CP SLC5A8 ATP1A1

4.17e-08841949ctd:D012964
Drugcholine

ENPP2 ETFDH BCAT1 PTPRS PLA2G6 SMPD3 DMGDH PLCZ1 HTR1B NTRK1 GRIK1 LCT RASSF1 ATP1A1

6.93e-0732019414CID000000305
DrugR 478

RYR2 ITPR3 HSPA4 AKAP1

1.61e-06111944CID000084223
DrugAC1L1DXE

RYR2 ITPR3 PNPLA6 NFKB1 CACNA1E HTR1B ANK3 NTRK1 NDST2 GRIK1 MMEL1 MTOR CACNA2D3

1.88e-0629919413CID000002548
DrugNSC7524

ENPP2 RYR2 ITPR3 SCN2A SCN3A CACNA1E HTR1B GRIK1 ATP1A1 CACNA2D3

3.85e-0618219410CID000005657
DrugPhensuximide [86-34-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A

TRPM4 PDLIM7 PNPLA6 PLA2G6 SRPX DNAH3 NDST2 ST3GAL2 IKBKE MACF1

6.78e-06194194103521_DN
Druglamotrigine

RYR2 ITPR3 MEST SCN2A SCN3A CACNA1E GRIK1 CACNA2D3

6.96e-061161948CID000003878
DrugGlycopyrrolate [596-51-0]; Down 200; 10uM; PC3; HT_HG-U133A

MCMBP MAN2C1 MANBA PER1 SCEL PTK6 SCN8A CDON NSD1 VPS41

7.76e-06197194107386_DN
DrugDoxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A

PDLIM7 PATZ1 PTK6 ARAP1 ANK3 ST3GAL2 PTPRU RLF SND1 IKBKE

7.76e-06197194101473_DN
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN8A

1.20e-0561943ctd:C475726
Druggabapentin

BCAT1 RYR2 ITPR3 MEST SCN3A CACNA1E GRIK1 GRM5 CACNA2D3

1.52e-051691949CID000003446
DiseaseIntellectual Disability

SNX3 PCDH12 SCN1A SCN3A SCN8A UGP2 ASCC3 DYNC1H1 CACNA1E NSD1 MTOR SLC4A10 MACF1 ATP1A1 RAI1

2.21e-0744718915C3714756
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN8A

3.32e-07101894DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN8A

3.32e-07101894DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN8A

7.75e-07121894DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

WWOX NFASC SCN1A SCN2A SCN3A SCN8A DYNC1H1 CACNA1E ATP1A1

1.15e-061631899DOID:1826 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A HTR1B

1.09e-05221894DOID:2030 (implicated_via_orthology)
DiseaseBipolar Disorder

DAO ADRB2 SCN2A SCN8A PLA2G6 HSPA4 HTR1B ANK3 NTRK1 PCLO GRIK1 GRM5 ATP1A1

1.37e-0547718913C0005586
DiseaseMalignant neoplasm of breast

MAN2C1 WWOX PDLIM7 OBSCN PER1 EZH2 SORCS1 PIK3R4 GPR180 AURKA OTOGL NLRP8 RAP1GAP VPS72 RCCD1 B3GALNT2 LLGL2 MTOR SLC6A5 MACF1

2.04e-05107418920C0006142
Diseasesmoking status measurement, chronic obstructive pulmonary disease

TET2 HLA-DQB1 ITGB8 SMPD3 HSPA4 FREM3

2.24e-05881896EFO_0000341, EFO_0006527
DiseaseHbA1c measurement

TET2 HLA-DQB1 ETFA ETFDH FIG4 USP4 ARAP1 DIP2B FREM3 RNF123 THADA SND1 MACF1 HACL1 RAI1

3.26e-0567518915EFO_0004541
DiseaseProfound Mental Retardation

SCN1A SCN8A ASCC3 DYNC1H1 NSD1 SLC4A10 RAI1

3.31e-051391897C0020796
DiseaseMental Retardation, Psychosocial

SCN1A SCN8A ASCC3 DYNC1H1 NSD1 SLC4A10 RAI1

3.31e-051391897C0025363
DiseaseMental deficiency

SCN1A SCN8A ASCC3 DYNC1H1 NSD1 SLC4A10 RAI1

3.31e-051391897C0917816
DiseaseVan Maldergem Wetzburger Verloes syndrome

FAT4 DCHS1

4.08e-0521892C1832390
DiseaseVan Maldergem syndrome

FAT4 DCHS1

4.08e-0521892cv:C1832390
DiseaseDown syndrome (biomarker_via_orthology)

RPLP0 RPLP0P6

4.08e-0521892DOID:14250 (biomarker_via_orthology)
DiseasePeriventricular gray matter heterotopia

FAT4 DCHS1

4.08e-0521892C1849173
Diseasecocaine use

SCN1A HSPA4 GRIK1

4.11e-05111893C3496069
Diseaseneurodegenerative disease (implicated_via_orthology)

PNPLA6 FIG4 NFKB1 PLA2G6 DYNC1H1 FAT4 GRIK1

4.34e-051451897DOID:1289 (implicated_via_orthology)
Diseaseunipolar depression, bipolar disorder

PURB ASCC3 CACNA1E FAT4 ANK3 PCLO GRM5

6.90e-051561897EFO_0003761, MONDO_0004985
Diseasebody surface area

PCSK5 ENPP2 PER1 ITGB8 MAP3K3 PDILT PLA2G6 P4HA2 NSD1 GPR139 MTOR MACF1 SENP2 EPB41L2

7.46e-0564318914EFO_0022196
Diseaseperceived unattractiveness to mosquitos measurement

HLA-DQB1 INPP5D P4HA2 LAMA5 GPR137B

1.01e-04721895EFO_0008380
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

1.22e-0431892cv:C5575231
Diseasemultiple acyl-CoA dehydrogenase deficiency (implicated_via_orthology)

ETFA ETFDH

1.22e-0431892DOID:0060358 (implicated_via_orthology)
DiseaseGlutaric Aciduria IIB

ETFA ETFDH

1.22e-0431892C1856403
DiseaseGlutaric Aciduria IIC

ETFA ETFDH

1.22e-0431892C1856405
DiseaseGlutaric Aciduria IIA

ETFA ETFDH

1.22e-0431892C1856401
Diseasemultiple acyl-CoA dehydrogenase deficiency (is_implicated_in)

ETFA ETFDH

1.22e-0431892DOID:0060358 (is_implicated_in)
DiseaseMultiple Acyl Coenzyme A Dehydrogenase Deficiency

ETFA ETFDH

1.22e-0431892C0268596
DiseaseMULTIPLE ACYL-CoA DEHYDROGENASE DEFICIENCY

ETFA ETFDH

1.22e-0431892231680
DiseaseHeterotopia, Periventricular, Autosomal Recessive

FAT4 DCHS1

1.22e-0431892C1842563
DiseaseMultiple acyl-CoA dehydrogenase deficiency

ETFA ETFDH

1.22e-0431892cv:C0268596
DiseaseThyroid carcinoma

ENPP2 PTGES2 RAP1GAP MTOR

1.81e-04441894C0549473
DiseaseSchizophrenia

HLA-DQB1 NFASC DAO PLA2G6 ANK3 NTRK1 CP GRIK1 GRM5 PITPNM1 MTOR ERVK-8 SLC6A5 PAK2 CTRL RAI1

1.93e-0488318916C0036341
Diseaseprimary biliary cirrhosis

TET2 MANBA HLA-DQB1 ITGB8 NFKB1 MMEL1

2.23e-041331896EFO_1001486
Diseasecreatinine measurement

TET2 MANBA OBSCN NEB PRDM8 NFKB1 PDILT PLA2G6 ASCC3 DMGDH P4HA2 VPS72 NSD1 LAMA5 RNF123 SND1 SENP2

2.43e-0499518917EFO_0004518
Diseasetropical spastic paraparesis (is_implicated_in)

HLA-DQB1 NFKB1

2.43e-0441892DOID:321 (is_implicated_in)
Diseaseneuroticism measurement, cognitive function measurement

TET2 FCHO1 SCN2A USP4 ASCC3 CACNA1E PCLO PTPRU GRM5 KIAA1217 MPHOSPH9 RAI1

3.11e-0456618912EFO_0007660, EFO_0008354
DiseaseNeurodevelopmental Disorders

PTK7 SCN1A SCN2A SCN8A CACNA2D3

3.37e-04931895C1535926
Diseasevital capacity

PCSK5 TET2 WWOX ENPP2 PER1 ITGB8 RYR2 MELTF ADRB2 ADAMTS15 DYNC1I1 DIP2B PCLO LCT TMEFF1 LLGL2 SENP2 EPB41L2 CACNA2D3

3.93e-04123618919EFO_0004312
DiseaseWeaver syndrome

EZH2 NSD1

4.03e-0451892C0265210
Diseasemigraine disorder, HOMA-B

ETFA ETFDH

4.03e-0451892EFO_0004469, MONDO_0005277
Diseasechronic myelomonocytic leukemia (is_implicated_in)

TET2 EZH2

4.03e-0451892DOID:0080188 (is_implicated_in)
Diseaseupper face morphology measurement

HLA-DQB1 ENPP2 ERO1B GPR137B MACF1

4.09e-04971895EFO_0010949
Diseasechronic obstructive pulmonary disease

TET2 WWOX HLA-DQB1 FRS2 ITGB8 ADRB2 SMPD3 HSPA4 ARAP2 HTR1B FREM3 MPHOSPH9 CACNA2D3

5.25e-0468818913EFO_0000341
Diseaseosteoarthritis, knee

EPPK1 ITPR3 DYNC1I1 VPS72 KIAA1217 MPHOSPH9

5.60e-041581896EFO_0004616
Diseasehemoglobin A1 measurement

TET2 ETFA ETFDH MELTF FARSA USP4 ARAP1 ARPC1B THADA PAK2 MACF1

5.63e-0452018911EFO_0007629
Diseaseforced expiratory volume

TET2 WWOX HLA-DQB1 ENPP2 FRS2 ITGB8 RYR2 ADRB2 FIG4 HSPA4 CDON DMGDH LLGL2 CACNA2D3

5.98e-0478918914EFO_0004314
Diseaseparoxysmal nocturnal hemoglobinuria (is_implicated_in)

HLA-DQB1 C5

6.02e-0461892DOID:0060284 (is_implicated_in)
Diseasedisease of metabolism (is_implicated_in)

ADRB2 TJP2

6.02e-0461892DOID:0014667 (is_implicated_in)
DiseasePrimary Myelofibrosis

TET2 EZH2

6.02e-0461892C0001815
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

6.02e-0461892C0220669
DiseaseLeukemia, Myelomonocytic, Chronic

TET2 EZH2

6.02e-0461892C0023480
Diseasetotal blood protein measurement

HLA-DQB1 NFKB1 USP4 ASCC3 ARAP1 IMPG2 DNAH3 SND1 IKBKE MACF1

6.76e-0444918910EFO_0004536
Diseasehippocampal volume

EPPK1 ETFA ETFDH RYR2 PURB ARAP2 KIAA1217 SLC4A10

6.93e-042971898EFO_0005035
DiseaseEpilepsy

PCDH12 SCN1A SCN2A SCN8A SLC4A10

6.97e-041091895C0014544
Diseaseglucose measurement

TET2 ETFA ETFDH ITPR3 ADRB2 ARAP1 RCCD1 THADA CACNA2D3

8.13e-043801899EFO_0004468
DiseaseHematopoetic Myelodysplasia

TET2 EZH2 SMPD3

8.36e-04291893C2713368
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

8.39e-0471892C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

8.39e-0471892C0751057
Diseasemyelodysplastic syndrome (is_implicated_in)

TET2 EZH2 ARPC1B

9.24e-04301893DOID:0050908 (is_implicated_in)
Diseasebasophil count, eosinophil count

INPP5D ITGB8 ADRB2 NFKB1 CCL24 P4HA2 PAK2

9.65e-042411897EFO_0004842, EFO_0005090
DiseaseMajor Depressive Disorder

CCL24 HTR1B PCLO FREM3 GRM5 IKBKE MTOR

1.01e-032431897C1269683
Diseasemyasthenia gravis (is_implicated_in)

HLA-DQB1 ADRB2

1.11e-0381892DOID:437 (is_implicated_in)
Diseasereticulocyte count

PATZ1 INPP5D FBXL18 PURB NFKB1 NFRKB PLA2G6 USP4 BAIAP3 HSPA4 RAP1GAP LAMA4 ARPC1B TRIM10 THADA RASSF1

1.19e-03104518916EFO_0007986
Diseasesmoking cessation

ENPP2 PTK6 ITPR3 SCN2A ARAP2 CACNA1E ANK3 KIAA1217

1.24e-033251898EFO_0004319
DiseaseTremor, Neonatal

ADRB2 SCN8A

1.43e-0391892C0235843
DiseaseFebrile Convulsions

SCN1A SCN2A

1.43e-0391892C0009952
DiseaseTremor, Perioral

ADRB2 SCN8A

1.43e-0391892C0235078
DiseaseNerve Tremors

ADRB2 SCN8A

1.43e-0391892C0235083
DiseaseTremor, Limb

ADRB2 SCN8A

1.43e-0391892C0235081
DiseaseTremor, Muscle

ADRB2 SCN8A

1.43e-0391892C0235082
DiseaseSenile Tremor

ADRB2 SCN8A

1.43e-0391892C0149840
DiseasePill Rolling Tremor

ADRB2 SCN8A

1.43e-0391892C0751564
DiseaseTremor, Semirhythmic

ADRB2 SCN8A

1.43e-0391892C0751565
DiseaseAction Tremor

ADRB2 SCN8A

1.43e-0391892C0234376
DiseasePassive Tremor

ADRB2 SCN8A

1.43e-0391892C0234377
DiseaseStatic Tremor

ADRB2 SCN8A

1.43e-0391892C0234378
DiseaseResting Tremor

ADRB2 SCN8A

1.43e-0391892C0234379
DiseaseIntermittent Tremor

ADRB2 SCN8A

1.43e-0391892C0234372
DiseaseFine Tremor

ADRB2 SCN8A

1.43e-0391892C0234373
DiseaseCoarse Tremor

ADRB2 SCN8A

1.43e-0391892C0234374
DiseaseMassive Tremor

ADRB2 SCN8A

1.43e-0391892C0234375
DiseasePersistent Tremor

ADRB2 SCN8A

1.43e-0391892C0234370
DiseaseContinuous Tremor

ADRB2 SCN8A

1.43e-0391892C0234371
DiseaseDarkness Tremor

ADRB2 SCN8A

1.43e-0391892C0234381
DiseaseInvoluntary Quiver

ADRB2 SCN8A

1.43e-0391892C1527384
Diseaseadult respiratory distress syndrome (implicated_via_orthology)

C5 HSPA4

1.43e-0391892DOID:11394 (implicated_via_orthology)
DiseaseSaturnine Tremor

ADRB2 SCN8A

1.43e-0391892C0040827
DiseaseDisorder of fatty acid metabolism

ETFA ETFDH

1.43e-0391892cv:C0268634
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A

1.43e-0391892C3502809
DiseaseAlzheimer disease, fasting blood glucose measurement

ETFA ETFDH

1.43e-0391892EFO_0004465, MONDO_0004975
Diseaseallergic disease

MANBA HLA-DQB1 INPP5D ITGB8 ITPR3 NFKB1 IKBKE

1.43e-032581897MONDO_0005271
Diseaseeosinophil count

TET2 WWOX PATZ1 HLA-DQB1 INPP5D ITGB8 ITPR3 MELTF ADRB2 NFKB1 CCL24 HSPA4 DIP2B DNAH3 DIRAS1 THADA IKBKE PAK2 MPHOSPH9 RAI1

1.45e-03148818920EFO_0004842
DiseaseThyroid Gland Follicular Adenoma

ENPP2 PTGES2 RAP1GAP

1.46e-03351893C0151468
DiseaseUnipolar Depression

CCL24 HTR1B PCLO FREM3 GRM5 IKBKE MTOR

1.46e-032591897C0041696
Diseasepeak expiratory flow

TET2 WWOX HLA-DQB1 ADRB2 FIG4 DMGDH ANK3 FREM3 THADA CACNA2D3

1.47e-0349818910EFO_0009718
DiseaseAutistic Disorder

PER1 DAO ADRB2 HTR1B NSD1 CP SND1

1.53e-032611897C0004352
DiseaseManic

SCN2A HSPA4 ANK3 NTRK1

1.61e-03781894C0338831
Diseasesusceptibility to scarlet fever measurement

MANBA HLA-DQB1 NFKB1 SDK2

1.68e-03791894EFO_0008409

Protein segments in the cluster

PeptideGeneStartEntry
VSRFYRAPEIIIGKS

PRPF4B

851

Q13523
VRAPAVYTRVSKFST

CTRL

241

P40313
ITDAVEYSAKRTPKR

HTR1B

151

P28222
EYVAEKLPSRFIESA

AKAP1

261

Q92667
VIAVDRYFAITSPFK

ADRB2

126

P07550
FFVSKRIPENRVVSY

CCL24

36

O00175
QTLETRDRKPFYTVD

ERVK-19

356

O71037
QTLETRDRKPFYTVD

ERVK-8

356

Q902F8
TLETRDRKPFYTVDL

ERVK-9

356

Q9UKH3
ETYKRISRVEFTFPD

AURKA

336

O14965
YRSAVRATLPVFDKE

BCAT1

121

P54687
QLYATVVRKSSFIPR

CCDC33

361

Q8N5R6
SRRLEKTEPYFIGIF

CACNA1E

121

Q15878
TEAIERVRKAKAPTY

BAIAP3

181

O94812
CRIFSAYIKEVEERP

ARPC1B

166

O15143
LRALSKVAPYFERSI

ERO1B

311

Q86YB8
PLTITYVREKVIDFS

GRIK1

531

P39086
LVDVYAIEKSTAFPR

FAT4

1706

Q6V0I7
EVPTAKFQELRYSVA

COMMD5

191

Q9GZQ3
DRTVKQSFEIITPYR

ARAP2

641

Q8WZ64
KTALYVTPLDRVTEF

CGGBP1

16

Q9UFW8
KSTRFKPTRIIFYRD

AGO3

656

Q9H9G7
VIAFTSEFIPRVVYK

ANO9

616

A1A5B4
SPEEVVRATRLAFEY

DHTKD1

401

Q96HY7
PVVSFRLVYDRETGK

CSTF2

41

P33240
FTTTTKEGYDRRPVD

CCDC90B

36

Q9GZT6
IRIFPVDKSRSREVY

DCAF13

306

Q9NV06
KRFVSIPRYVETLVV

ADAMTS15

211

Q8TE58
DTTSLDRPRRVEYFV

RCCD1

336

A6NED2
SPFVRVEKRDAFTTI

RAI1

1596

Q7Z5J4
VISKYTPESVLRERF

RBM45

31

Q8IUH3
FSKRQYPEVEIFRTL

NSD1

1936

Q96L73
SVRRRTSFYLPKDAV

RASSF1

201

Q9NS23
RRVFKTEVATVYAPA

INSYN2A

246

Q6ZSG2
KTDSFVPRNSYVRLR

ITPR3

376

Q14573
AIPFVIEKAVRSSIY

HACL1

146

Q9UJ83
DIKVYADRFTPLTTT

DAO

31

P14920
NAPVFEKSRYEVSTR

PCDH12

456

Q9NPG4
QYTDSTFRVPVERKA

CP

786

P00450
FIRERATIEETYSKA

FCHO1

36

O14526
VFTRASYRVTVPEDT

DCHS1

2601

Q96JQ0
FSAVFTKYPESLVRV

PNPLA6

301

Q8IY17
PESILYRKFTTESDV

NTRK1

696

P04629
ETVSEEKRIYRVPVF

OGFOD2

131

Q6N063
RSPSRDKAVAVFYTI

OR2AK2

281

Q8NG84
FIIYRDTPVVKSSSR

GRM5

601

P41594
AFKVREFSITDVVPY

HSPA4

386

P34932
YKLSTVRVFLTDTDP

LLGL2

461

Q6P1M3
TDYVVRPSTGEEKRV

NFRKB

506

Q6P4R8
PVSSDLKYTLRFRTV

IL31RA

151

Q8NI17
VFVRYISSLFPTRAE

NLRP8

426

Q86W28
FRPSRVVVVAKTTRY

NADK2

66

Q4G0N4
YRSQRFKETERPSIK

ANLN

676

Q9NQW6
RERYAKIVEIPFNST

ATP1A1

471

P05023
AVKVFNTTSYLRPRE

IKBKE

36

Q14164
VDFLPREVVSYSKET

DYNC1I1

156

O14576
AFSVAVTKSYPRERL

C1QTNF2

151

Q9BXJ5
YIKVRPAELEQFEST

EPB41L2

456

O43491
VYEFRVKESSIIAPA

EZH2

466

Q15910
FRLTPYVTKIRVSDG

PER1

316

O15534
KSEFVDDITTRREPY

PCLO

1496

Q9Y6V0
TNEFPKVERFRYSRV

PCSK5

606

Q92824
YIRIFSTVLRIPSAE

OR14J1

216

Q9UGF5
RTFPIDKSVSVFYTV

OR4A47

261

Q6IF82
YIRPVTTFSEDKVFA

OR4P4

256

Q8NGL7
ESIKTVYRGRIAVFS

DIP2B

836

Q9P265
EYTAKIRTLAETERF

MPHOSPH9

951

Q99550
VYLNSSSKRVIFPRV

PNPLA1

261

Q8N8W4
LPSFTEEEKRFIRAT

LCT

1186

P09848
SLESKYVFFRPTIQV

LRRC71

116

Q8N4P6
LIVQDKESVFSPRRY

LAMP3

246

Q9UQV4
TDDTLKRFSVRYLRP

TWNK

186

Q96RR1
TVERSTLKREFYITF

GPR180

346

Q86V85
YSPLLREFTKATNVR

LAMA5

246

O15230
VEVKFARTPVTSTYL

NPEPPSL1

231

A6NEC2
SYRPEFAIQSIKTDV

MMEL1

726

Q495T6
VDRLAASFIPTTYEK

SMPD3

31

Q9NY59
KRVLALSVETDYTFP

RPLP0

246

P05388
AERYAPDKTSTVLTR

PDLIM7

231

Q9NR12
VSRPDSKEVRYLEFS

MACF1

3196

Q9UPN3
PVYDTTIRTGRALKE

MACF1

6606

Q9UPN3
AFLIRVSEKPSADYV

PTK6

101

Q13882
RTFDPTTSYVVEDLK

PTPRS

571

Q13332
LVKTETLAEYVVRTF

PTPRU

1016

Q92729
VRDPKTGVLTVASYR

P4HA2

366

O15460
VEYSPSRIREFIISE

PPP4R3C

391

Q6ZMV5
RPSSTYSLERDKVAA

OR9G4

276

Q8NGQ1
SVDFRLRVSEPKVVF

OBSCN

876

Q5VST9
AYTSRIVVRLESFPE

PATZ1

121

Q9HBE1
SVCTRAVTYRREKPE

ITGB8

736

P26012
KFTVQRTDPVSRYRF

NFASC

991

O94856
RPDHTKSIYTRSVID

PAK2

186

Q13177
RFVKGTFRDTYIPTI

DIRAS1

26

O95057
RFDSDVEVYRAVTPL

HLA-DQB1

71

P01920
PVTEDRFGILTEKYR

ETFDH

141

Q16134
SYRSRLQFSTPKEEV

CDHR2

1046

Q9BYE9
FLPSITRKRRYVASV

KLHL12

311

Q53G59
TKTIYRDAVENFLPT

DNAH3

2251

Q8TD57
TLETRDRKPFYTVDL

ERVK-24

246

P61566
QTLETRDRKPFYTVD

ERVK-25

356

P61570
QTLETRDRKPFYTID

ERVK-6

356

Q69384
TEYPAFVSERTIKET

CACNA2D3

971

Q8IZS8
PVYVTLIARRSSKFA

FIG4

266

Q92562
FTIKRAETSTLVYEP

FNDC11

281

Q9BVV2
KIEYSRRRDCTPTVF

FRS2

406

Q8WU20
EDRVVSVSFRVLYPI

B3GALNT2

141

Q8NCR0
TLRVVPEGVKRESYS

C5

926

P01031
EVRSLEPGSTYKFRV

CDON

781

Q4KMG0
RKFTRDTDKTPQSIY

CFAP107

36

Q8N1D5
VRASPLFYESRITLK

IDI2-AS1

96

Q9NZ38
AIEEVKTRTIRSPYT

APBA1

356

Q02410
ITKDFPQYFAVVSRI

ANK3

1126

Q12955
IIRESIRKFPYCEAT

ANKMY2

266

Q8IV38
TKTLARFIPEVAVAY

BPIFB6

291

Q8NFQ5
TLETRDRKPFYTVDL

ERVK-21

356

P61565
KTETEFYRRSRSEIV

MANBA

631

O00462
RLATTPVRVDEFKYQ

DMGDH

136

Q9UI17
RTTLERVEKFVSPLY

MAN2C1

11

Q9NTJ4
LRSVVTPARVQFKTY

LYPLA2

191

O95372
PFAISLIESVRTYER

DYNC1H1

776

Q14204
YLSTEFDSVRQRLPK

KRBOX4

131

Q5JUW0
QTLETRDRKPFYTID

HERVK_113

356

Q902F9
YPARTRKVIVSVYIT

GPR139

141

Q6DWJ6
KPESVYLFRITAQTR

SDK2

1366

Q58EX2
SAKRIERVYFEISES

RYR2

4141

Q92736
EFLELYRKTLPRSTV

MEST

291

Q5EB52
RREPTVSSFYVKRAE

NOC4L

221

Q9BVI4
LDFFRKTSRSYPEIL

ENPP2

836

Q13822
RVSEVKPSYRNAITV

PURB

246

Q96QR8
RIIAFSRPVKYEDVE

MAP3K3

56

Q99759
TVYTRRDVLPLGKFT

MCMBP

376

Q9BTE3
SFSIEEIQAAVPYRK

OTOGL

1356

Q3ZCN5
PTRYELIVDKSRVGS

LAMA4

1321

Q16363
SVAVRSEFKVYLPRV

MTOR

441

P42345
RVFKYFRVTEVDIPS

PDILT

321

Q8N807
RARLYDVVAVFPKTE

RPP30

96

P78346
FPTTKVTILADRYDE

FREM3

1996

P0C091
TTLVVYFFRVRNPTK

GPR137B

306

O60478
VREPVRYFSSVEEVA

GAREM2

96

Q75VX8
GISDYPKIRVTVTRD

SENP2

126

Q9HC62
YVSAFRPVVKDTESI

SKOR1

591

P84550
KRVLALSVETDYTFP

RPLP0P6

246

Q8NHW5
RTYPSSREASVDEKR

TRMT44

506

Q8IYL2
PAAEFVKTVEFTRLR

THADA

1891

Q6YHU6
DKTVPERSSFYDRRV

TATDN2

261

Q93075
ATVRAVPVGEKTTYR

MELTF

676

P08582
TPVKYFSIDRVFRNE

FARSA

346

Q9Y285
IVTSISDEFPKYLRT

SLC6A5

586

Q9Y345
LKTDAASRPYADVRV

NKTR

156

P30414
KFITRIYPKATRADS

PLCZ1

401

Q86YW0
PKYFLLEQSTTVRER

IQCA1L

121

A6NCM1
IAIKSPDTFVRTIYA

ETFA

136

P13804
SRVRELKQTLFTPSY

FBXL18

171

Q96ME1
KSTDKRTVPYIFRVD

PRDM8

61

Q9NQV8
SSPYFTEDRKRELIQ

EPPK1

1801

P58107
LYKVSVTARDDVPFF

RAP1GAP

331

P47736
EEITFAPTYRFERLT

INPP5D

636

Q92835
FAYSTATIPKDRETR

KIAA1217

546

Q5T5P2
PISRTDEIRKNTYRT

KIAA1217

1651

Q5T5P2
IRFTYAPVKSFLRVD

ST3GAL2

236

Q16842
TIAIRVPYARVSEFD

SHQ1

16

Q6PI26
IADVYSKFRPVKRVS

SNCAIP

66

Q9Y6H5
KERSASYKPVFVTEI

SND1

676

Q7KZF4
AAVTVEDLIKPYFRS

SLC5A8

361

Q8N695
EVNPVRRAEIKFSSY

PTGES2

131

Q9H7Z7
EKYFVSPTLFRVIRL

SCN3A

1611

Q9NY46
PFRVKEVAVADYTSS

PLA2G6

21

O60733
LDDKPTVVYTISNFR

IMPG2

341

Q9BZV3
FYEKRRLLIVSTPTA

SRPX

336

P78539
EKYFVSPTLFRVIRL

SCN1A

1626

P35498
KEVDRRSFDLTTPYR

ARAP1

491

Q96P48
KTRRYVDFPITDVLQ

ASCC3

1671

Q8N3C0
AATIKAEFVRAETPY

CILP

296

O75339
KEPVSRSIFDYALRS

PIK3R4

721

Q99570
RTRYTCPFVEKFSIE

PITPNM1

96

O00562
FTKVQDYLRRFESIP

UGP2

436

Q16851
SVSTKFPAYERVLLR

TJP2

711

Q9UDY2
ECVTLPVYFRERKSR

USP4

576

Q13107
PEFRKVSIAATIIYA

YIPF1

156

Q9Y548
EFTEKYVVPRTRLAS

MKRN2OS

176

H3BPM6
YLRPVVVLERSKFST

RLF

1881

Q13129
YRITTKSTRVEFDLP

SNX30

111

Q5VWJ9
KSTRVEFDLPEYSVR

SNX30

116

Q5VWJ9
AFKVREFSITDLVPY

HSPA4L

386

O95757
FRDRLGTVYEKFITP

HSPA4L

631

O95757
RSVVFFYIKSPLRVE

RNF123

431

Q5XPI4
VNERDVPKATISRYS

SCEL

76

O95171
ETKHSFALYTPERTR

TECPR1

676

Q7Z6L1
YFPTKVRSIVSDFAV

SLC4A10

751

Q6U841
PEVDIFRLIRTSYEK

TBC1D9

766

Q6ZT07
EKYFVSPTLFRVIRL

SCN2A

1616

Q99250
ARTEPVVLVFVESAY

NDST2

81

P52849
KRTTYLDPRLAFTVD

WWOX

81

Q9NZC7
IEKYFVSPTLFRVIR

SCN8A

1606

Q9UQD0
VSYEPITTTLRRKQE

SCN8A

1881

Q9UQD0
FTTYEIRVKTNLPIF

SNX3

46

O60493
FYIVSPRDVVVAKER

VPS41

346

P49754
EPIYTFTASFTRKVI

TRIM10

451

Q9UDY6
YAFPRVRIITTAVDK

UCKL1

496

Q9NWZ5
EKTDFSILYVVPSRQ

TMEFF1

311

Q8IYR6
TDIPYATARAFKIIR

VPS72

306

Q15906
DTKTIAVYEEFRSLR

SORCS1

966

Q8WY21
TIYFGTRDERVEKLP

TTLL4

586

Q14679
EPTYLRFIKSLAERT

TET2

1961

Q6N021
FITFKVEPERTTVYQ

PTK7

591

Q13308
PLIYTRLITFRKSEE

TRPM4

701

Q8TD43
DTSFRISVFKLPIYT

LRRIQ3

346

A6PVS8
DTIYRQRPETLKFTS

NEB

3416

P20929
SFTRRLEPVVSDAIY

NFKB1

226

P19838