Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentextracellular matrix

THBS3 HMCN2 COMP ADAMTS7 LAMA5 LRRN2 ALB ADAMTSL4

5.47e-04656608GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

THBS3 HMCN2 COMP ADAMTS7 LAMA5 LRRN2 ALB ADAMTSL4

5.58e-04658608GO:0030312
MousePhenoabnormal vascular wound healing

COMP ADAMTS7 IRS1 IL1R1 MAP3K1

3.51e-0673455MP:0004883
DomainNBPF_dom

NBPF9 NBPF11 NBPF14 NBPF1

2.19e-0811554IPR010630
DomainNBPF

NBPF9 NBPF11 NBPF14 NBPF1

2.19e-0811554PS51316
DomainDUF1220

NBPF9 NBPF11 NBPF14 NBPF1

2.19e-0811554PF06758
DomainDUF1220

NBPF9 NBPF11 NBPF1

2.00e-069553SM01148
DomainThbs/COMP_coiled-coil

THBS3 COMP

2.55e-053552IPR024665
DomainCOMP

THBS3 COMP

2.55e-053552PF11598
DomainTSP_3

THBS3 COMP

8.47e-055552PF02412
DomainTSP3

THBS3 COMP

8.47e-055552PS51234
DomainTSP_CTER

THBS3 COMP

8.47e-055552PS51236
Domain-

THBS3 COMP

8.47e-0555524.10.1080.10
DomainThrombospondin_C

THBS3 COMP

8.47e-055552IPR008859
DomainTSP_C

THBS3 COMP

8.47e-055552PF05735
DomainThrombospondin_3_rpt

THBS3 COMP

8.47e-055552IPR017897
DomainThrombospondin_3-like_rpt

THBS3 COMP

8.47e-055552IPR003367
DomainTSP_type-3_rpt

THBS3 COMP

8.47e-055552IPR028974
DomainGrowth_fac_rcpt_

THBS3 HMCN2 IGFBP3 COMP LAMA5

9.47e-05156555IPR009030
DomainConA-like_dom

BTN3A3 BTN2A2 THBS3 COMP LAMA5

4.57e-04219555IPR013320
DomainPLAC

ADAMTS7 ADAMTSL4

1.41e-0319552PS50900
DomainPLAC

ADAMTS7 ADAMTSL4

1.41e-0319552IPR010909
DomainIG

BTN3A3 BTN2A2 HMCN2 MCAM LRRN2 IL1R1

1.44e-03421556SM00409
DomainIg_sub

BTN3A3 BTN2A2 HMCN2 MCAM LRRN2 IL1R1

1.44e-03421556IPR003599
DomainADAM_spacer1

ADAMTS7 ADAMTSL4

2.07e-0323552IPR010294
DomainADAM_spacer1

ADAMTS7 ADAMTSL4

2.07e-0323552PF05986
DomainEGF_CA

THBS3 HMCN2 COMP

2.08e-0386553PF07645
Domain-

THBS3 COMP LAMA5

2.76e-03955532.60.120.200
DomainEGF_Ca-bd_CS

THBS3 HMCN2 COMP

2.93e-0397553IPR018097
DomainEGF_CA

THBS3 HMCN2 COMP

3.10e-0399553PS01187
DomainIG_LIKE

BTN3A3 BTN2A2 HMCN2 MCAM LRRN2 IL1R1

3.12e-03491556PS50835
DomainIg-like_dom

BTN3A3 BTN2A2 HMCN2 MCAM LRRN2 IL1R1

3.51e-03503556IPR007110
DomainCadherin

PCDH15 PCDHA12 RET

4.50e-03113553PF00028
DomainCADHERIN_2

PCDH15 PCDHA12 RET

4.61e-03114553PS50268
Domain-

PCDH15 PCDHA12 RET

4.61e-031145532.60.40.60
DomainCA

PCDH15 PCDHA12 RET

4.73e-03115553SM00112
DomainCadherin-like

PCDH15 PCDHA12 RET

4.84e-03116553IPR015919
DomainCadherin

PCDH15 PCDHA12 RET

5.08e-03118553IPR002126
DomainEGF_CA

THBS3 HMCN2 COMP

5.57e-03122553SM00179
DomainEGF-like_Ca-bd_dom

THBS3 HMCN2 COMP

5.83e-03124553IPR001881
DomainEGF-like_dom

THBS3 HMCN2 COMP LAMA5

6.18e-03249554IPR000742
DomainC2-set_2

BTN2A2 MCAM

6.49e-0341552PF08205
DomainCD80_C2-set

BTN2A2 MCAM

6.49e-0341552IPR013162
DomainEGF_1

THBS3 HMCN2 COMP LAMA5

6.71e-03255554PS00022
DomainPRY

BTN3A3 BTN2A2

6.80e-0342552PF13765
DomainEGF-like_CS

THBS3 HMCN2 COMP LAMA5

7.27e-03261554IPR013032
DomainEGF_2

THBS3 HMCN2 COMP LAMA5

7.67e-03265554PS01186
DomainPRY

BTN3A3 BTN2A2

8.81e-0348552SM00589
DomainPRY

BTN3A3 BTN2A2

8.81e-0348552IPR006574
Pubmed

A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.

NBPF8 NBPF19 NBPF12 NBPF9 NBPF10 NBPF11 NBPF14 NBPF20 NBPF1

2.45e-202161916079250
Pubmed

Evolutionary history and genome organization of DUF1220 protein domains.

NBPF8 NBPF12 NBPF9 NBPF14 NBPF1

3.51e-121061522973535
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

NBPF8 NBPF12 NBPF9 NBPF10 NBPF11 NBPF14 NBPF1

2.06e-0817061723314748
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

NBPF8 NBPF12 SH3PXD2A NBPF9 APC2 NBPF10 NBPF11 NBPF14 NBPF1

2.71e-0751361925798074
Pubmed

Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.

NBPF11 NBPF1

3.03e-0626127700633
Pubmed

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice.

HMGCR UBIAD1

3.03e-06261230785396
Pubmed

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration.

COMP ADAMTS7

3.03e-06261238528617
Pubmed

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.

HMGCR UBIAD1

3.03e-06261225742604
Pubmed

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with aortic aneurysm.

COMP ADAMTS7

3.03e-06261228849199
Pubmed

Structure and evolution of the extended B7 family.

BTN3A3 BTN2A2

3.03e-06261210354554
Pubmed

ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.

COMP ADAMTS7

3.03e-06261216585064
Pubmed

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion.

COMP ADAMTS7

3.03e-06261230720083
Pubmed

Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase.

HMGCR UBIAD1

3.03e-06261231323021
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DGCR2 DNAJC14 ADAMTS7 CTC1 KCNG1 LAMA5 IRS1 PRAG1 DUS1L NBPF1 WDR24

3.09e-061105611135748872
Pubmed

MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression.

IRS1 MAP3K1

9.07e-06361212458213
Pubmed

Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.

THBS3 COMP

9.07e-06361233910854
Pubmed

Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development.

SLC30A8 IRS1

9.07e-06361228072873
Pubmed

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.

COMP ADAMTS7

9.07e-06361225712208
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NBPF19 NBPF9 APC2 RET NBPF14 NBPF20 MAP3K1

1.03e-0543061735044719
Pubmed

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.

TCF20 SLC30A8 IRS1

1.46e-052761320490451
Pubmed

Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90.

SPINT2 ADAMTSL4

1.81e-05461216364318
Pubmed

No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk.

IGFBP3 IRS1

1.81e-05461218615538
Pubmed

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.

COMP ADAMTS7

1.81e-05461218485748
Pubmed

Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States.

IGFBP3 IRS1

1.81e-05461217051426
Pubmed

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.

CD14 IL1R1

1.81e-05461223708119
Pubmed

Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.

IGFBP3 IRS1

1.81e-05461215247132
Pubmed

The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes.

HMGCR UBIAD1

1.81e-05461223169578
Pubmed

Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels.

IGFBP3 IRS1

1.81e-05461218398029
Pubmed

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.

THBS3 COMP

3.02e-05561230622267
Pubmed

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice.

HMGCR ALB

3.02e-0556127798939
Pubmed

Insulin-like growth factor pathway polymorphisms associated with body size in Hispanic and non-Hispanic white women.

IGFBP3 IRS1

3.02e-05561216030120
Pubmed

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.

ALB EPAS1

3.02e-05561230352047
Pubmed

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.

THBS3 COMP

3.02e-05561218467703
Pubmed

IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.

IGFBP3 IRS1

3.02e-05561217044098
Pubmed

Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.

NBPF11 NBPF1

3.02e-05561220096688
Pubmed

Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.

TRAF3IP2 IL1R1

4.52e-05661229101209
Pubmed

BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.

BTN3A3 BTN2A2

4.52e-05661220208008
Pubmed

Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer.

IGFBP3 IRS1

4.52e-05661216448675
Pubmed

PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).

IGFBP3 IRS1

4.52e-05661216489531
Pubmed

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.

ALB EPAS1

4.52e-05661226853750
Pubmed

Leptin is better than any other biological parameter for monitoring the efficacy of renutrition in hospitalized malnourished elderly patients.

IGFBP3 ALB

4.52e-05661221521316
Pubmed

Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions.

IGFBP3 IRS1

6.32e-05761218059035
Pubmed

Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.

IL1R1 MAP3K1

6.32e-05761216286467
Pubmed

Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.

TRAF3IP2 IL1R1

6.32e-05761225014791
Pubmed

[A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer].

IGFBP3 IRS1

6.32e-05761220540360
Pubmed

The cluster of BTN genes in the extended major histocompatibility complex.

BTN3A3 BTN2A2

6.32e-05761211170752
Pubmed

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.

COMP CD14 BGLAP

6.46e-054461321308778
Pubmed

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

SLC30A8 IRS1

8.42e-05861219734900
Pubmed

Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.

THBS3 COMP

8.42e-05861224460873
Pubmed

A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.

CD14 IL1R1

1.08e-04961225362351
Pubmed

Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.

COMP BGLAP

1.08e-04961231199918
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

HMCN2 COMP MCAM LAMA5

1.29e-0414661427068509
Pubmed

Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies.

TCF20 SLC30A8

1.35e-041061219082521
Pubmed

The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent.

CD14 IL1R1

1.35e-041061216081822
Pubmed

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.

IGFBP3 IRS1

1.35e-041061220416304
Pubmed

Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.

IGFBP3 IRS1

1.35e-041061219124510
Pubmed

Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

TCF20 SLC30A8

1.35e-041061220509872
Pubmed

Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.

IGFBP3 IRS1

1.35e-041061221852217
Pubmed

Genetic mapping of the tumor-associated mucin 1 gene on mouse chromosome 3.

THBS3 BGLAP

1.35e-04106127626896
Pubmed

Common type 2 diabetes risk gene variants associate with gestational diabetes.

TCF20 SLC30A8

2.33e-041361218984664
Pubmed

Lineage-specific gene duplication and loss in human and great ape evolution.

NBPF19 NBPF9 NBPF20

2.48e-046961315252450
Pubmed

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.

PCDH15 TRIOBP

2.72e-041461226754646
Pubmed

The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.

MAP3K8 LAMA5

2.72e-04146129151674
Pubmed

MAP3Ks as central regulators of cell fate during development.

MAP3K8 MAP3K1

3.13e-041561218855897
Pubmed

MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.

CD14 IL1R1

3.13e-041561217339472
Pubmed

Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.

SLC30A8 IRS1 HMGCR

3.17e-047561320571754
Pubmed

Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity.

COMP BGLAP

3.57e-041661237683603
Pubmed

The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development.

COMP BGLAP

3.57e-041661235140200
Pubmed

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.

IRS1 MAP3K1

4.05e-041761223754948
Pubmed

A 1.1-Mb transcript map of the hereditary hemochromatosis locus.

BTN3A3 BTN2A2

4.55e-04186129149941
Pubmed

Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses.

CD14 BGLAP

5.08e-041961216705022
Pubmed

PTEN identified as important risk factor of chronic obstructive pulmonary disease.

IGFBP3 CD14 IRS1 HMGCR RET

5.08e-0437461519625176
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

IGFBP3 CD14 IRS1 HMGCR RET

5.53e-0438161518676680
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

IGFBP3 CD14 IRS1 HMGCR RET

5.59e-0438261519170196
Pubmed

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

IGFBP3 IRS1 IL1R1 MAP3K1 BGLAP

5.66e-0438361519453261
Pubmed

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

TCF20 SLC30A8

6.22e-042161218591388
Pubmed

Underlying genetic models of inheritance in established type 2 diabetes associations.

TCF20 SLC30A8

6.22e-042161219602701
Pubmed

A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice.

COMP EPAS1

6.22e-042161225340332
Pubmed

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.

COMP HMGCR

6.83e-042261225147951
Pubmed

Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling.

RET EPAS1

6.83e-042261225587709
Pubmed

Integrative predictive model of coronary artery calcification in atherosclerosis.

IGFBP3 CD14 HMGCR IL1R1

7.12e-0422961419948975
Pubmed

Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study.

TCF20 SLC30A8

7.48e-042361219720844
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

IGFBP3 CD14 IRS1 HMGCR RET

8.65e-0442161519692168
Pubmed

Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.

IGFBP3 IRS1

8.84e-042561218992263
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

IGFBP3 COMP ADAMTS7 ADAMTSL4

9.57e-0424861424006456
Pubmed

Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism.

SLC30A8 IRS1

1.03e-032761220384434
Pubmed

WFS1 Spectrum Disorder

SLC30A8 IRS1

1.11e-032861220301750
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

DGCR2 THBS3 HSPH1 MCAM LAMA5 NBPF26 HMGCR UBIAD1

1.15e-03120161835696571
Pubmed

Obesity and diabetes genetic variants associated with gestational weight gain.

TCF20 SLC30A8

1.19e-032961220816152
Pubmed

Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.

DGCR2 RET

1.28e-03306129405660
Pubmed

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.

IGFBP3 CD14 IL1R1

1.40e-0312561319019335
Pubmed

Genome-wide association study of lung function decline in adults with and without asthma.

PCDH15 DEUP1

1.45e-033261222424883
Pubmed

Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.

IGFBP3 CD14 IL1R1

1.50e-0312861318818748
Pubmed

Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.

IGFBP3 CD14 IL1R1

1.50e-0312861319527514
Pubmed

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

COMP BGLAP

1.54e-033361212414734
Pubmed

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

SLC30A8 IRS1

1.64e-033461220581827
Pubmed

Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

IGFBP3 IRS1

1.73e-033561218992148
InteractionNEK4 interactions

NBPF8 NBPF12 SH3PXD2A NBPF9 APC2 NBPF10 PCDHA12 NBPF11 NBPF14 NBPF1

8.95e-065826110int:NEK4
InteractionDIP2A interactions

THBS3 SPINT2 MCAM RET ADAMTSL4

1.06e-0596615int:DIP2A
InteractionADAM12 interactions

NBPF19 IGFBP3 SH3PXD2A ADAMTSL4

2.85e-0558614int:ADAM12
Cytoband1q21.1

NBPF8 NBPF9 NBPF10 NBPF11 NBPF14

2.32e-08626251q21.1
CytobandEnsembl 112 genes in cytogenetic band chr1q21

NBPF19 NBPF12 NBPF9 NBPF10 NBPF11 NBPF14 ADAMTSL4 NBPF20

7.49e-08404628chr1q21
CytobandEnsembl 112 genes in cytogenetic band chr1p11

NBPF8 NBPF26

3.71e-0421622chr1p11
GeneFamilyNeuroblastoma breakpoint family

NBPF8 NBPF19 NBPF12 NBPF9 NBPF10 NBPF26 NBPF11 NBPF14 NBPF20 NBPF1

3.48e-21234510662
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTN3A3 BTN2A2

6.23e-0415452458
GeneFamilyCadherin related

PCDH15 RET

8.04e-041745224
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K8 MAP3K1

1.61e-0324452654
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

BTN2A2 MCAM

4.45e-0340452592
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HMCN2 LRRN2 IL1R1

7.48e-03161453593
GeneFamilyAdenosine receptors|V-set domain containing

BTN3A3 BTN2A2 MCAM

7.74e-03163453590
GeneFamilyImmunoglobulin like domain containing

HMCN2 MCAM IL1R1

1.22e-02193453594
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS3 HMCN2 IGFBP3 COMP LAMA5 BGLAP

5.51e-06191616MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS3 HMCN2 IGFBP3 COMP LAMA5 BGLAP

6.39e-06196616M3008
CoexpressionSCHEIDEREIT_IKK_INTERACTING_PROTEINS

TRAF3IP2 MAP3K8 IRS1 EPAS1

7.14e-0653614M6303
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL

THBS3 SPINT2 KLF13 MAP3K8 ZNF174 NBPF9 LAMA5 NBPF26 IL1R1 ADAMTSL4 NBPF20

1.12e-059556111M45680
CoexpressionGSE27241_CTRL_VS_DIGOXIN_TREATED_CD4_TCELL_IN_TH17_POLARIZING_CONDITIONS_UP

KLF13 MAP3K8 MCAM PRDM15 ADAMTSL4

3.81e-05162615M8243
CoexpressionNABA_CORE_MATRISOME

THBS3 HMCN2 IGFBP3 COMP LAMA5 BGLAP

3.90e-05270616MM17057
CoexpressionNABA_CORE_MATRISOME

THBS3 HMCN2 IGFBP3 COMP LAMA5 BGLAP

4.32e-05275616M5884
CoexpressionGSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN

DGCR2 BTN3A3 TCF20 NBPF10 PPIP5K1

9.64e-05197615M3465
CoexpressionGSE21670_IL6_VS_TGFB_AND_IL6_TREATED_STAT3_KO_CD4_TCELL_DN

SPINT2 ADAMTS7 PPIP5K1 UBIAD1 PRDM15

1.01e-04199615M7451
ToppCellCOPD-Myeloid-cMonocyte|COPD / Disease state, Lineage and Cell class

NBPF19 CD14 MAP3K8 NBPF10 NBPF26 NBPF14

2.57e-07189626d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCellCOPD-Myeloid-cMonocyte|Myeloid / Disease state, Lineage and Cell class

NBPF19 CD14 MAP3K8 NBPF26 IL1R1 NBPF14

2.57e-071896266294691231c7d38707323cf31578a107d3b2c622
ToppCellControl-B_intermediate-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NBPF12 NBPF10 NBPF11 PRAG1 NBPF1

1.75e-06144625984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NBPF12 NBPF10 NBPF11 PRAG1 NBPF1

3.62e-06167625948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF473 ZNF174 IL1R1 NBPF14 EPAS1

4.42e-0617462558300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

HMCN2 COMP SH3PXD2A CDC42EP5 IRS1

5.80e-061846250b336489c10e8c3c957795dd845454f03404382b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NBPF19 IGFBP3 NBPF10 RET NBPF14

5.80e-06184625658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3PXD2A SLC30A8 HMGCR RET IL1R1

7.14e-061926255b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellNS-critical-d_16-33-Epithelial-Secretory|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

IGFBP3 SH3PXD2A CDC42EP5 IRS1 EPAS1

8.08e-06197625a72047b7428c0d4aaf016c1ac23dc30919260fd8
ToppCellEndothelial_cells-Endothelial-A|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id

IGFBP3 MCAM LAMA5 IL1R1 EPAS1

8.49e-061996252a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

NBPF19 NBPF10 NBPF26 PRAG1 NBPF14

8.70e-0620062547791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1|Neuronal / cells hierarchy compared to all cells using T-Statistic

NBPF19 NBPF10 NBPF26 PRAG1 NBPF14

8.70e-06200625f75d95376a340d467c4392b872b2a2dbdd184556
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

NBPF19 NBPF10 NBPF26 PRAG1 NBPF14

8.70e-06200625fae26560ba3b0b638b6bcf92f05330824b31d21b
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_2|343B / Donor, Lineage, Cell class and subclass (all cells)

CD14 HSPH1 ADAMTSL4 MAP3K1

6.47e-0515562484221a285277292f7225eb69508c887541abeed1
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NBPF19 NBPF10 NBPF26 HMGCR

6.47e-051556245fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCellSevere-B_naive-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TCF20 NBPF10 PRAG1 NBPF1

7.14e-051596242881b054bbeb479221ee3c38bbd9b0815b123579
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

HMCN2 COMP SH3PXD2A DEUP1

8.05e-051646249b4a6007abae992db871d9f6f731d5af724de30d
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRAF3IP2 KCNG1 SH3PXD2A IRS1

9.46e-0517162423b3120706bb9c20b9214fe3760c6d7a84f1e749
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF473 ZNF174 NBPF14 EPAS1

9.90e-05173624efb8072475000888efe088d00e870c56ffad4172
ToppCelldroplet-Heart-4Chambers-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPINT2 KCNG1 PCDHA12 EPAS1

9.90e-051736249a04271c51fae34f547db3206f9ff5857686e45c
ToppCell10x5'v1-week_17-19-Lymphocytic_NK-T_NK-ILC_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MAP3K8 TOGARAM2 IL1R1 EPAS1

1.13e-04179624d18a520568cf4b031972d3dd7d4d4bd073ac1fea
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NBPF19 NBPF9 NBPF10 NBPF26

1.15e-04180624b234668bf181522807470e396792e1b54890b719
ToppCellCOVID-19_Convalescent|World / Disease condition and Cell class

NBPF19 NBPF26 NBPF14 NBPF20

1.18e-04181624a62115a8da486fc61225901c72b1ec70bcaf4c36
ToppCellCOPD-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

NBPF19 MAP3K8 NBPF26 NBPF14

1.25e-04184624ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

IGFBP3 MCAM IRS1 PRAG1

1.34e-04187624387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THBS3 TRIOBP RET ADAMTSL4

1.36e-04188624aa516273cdde53c8c0295f06830972388f890c97
ToppCelldroplet-Fat-SCAT-30m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP3 MCAM LAMA5 EPAS1

1.36e-041886245cf060bb8adaefa9964187195d67993c1248ef47
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCAM LAMA5 EPAS1 DEUP1

1.36e-04188624405efea75233ecf70f7d19b630230798d817b7f2
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3PXD2A SLC30A8 HMGCR IL1R1

1.36e-04188624a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCelldroplet-Fat-SCAT-30m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP3 MCAM LAMA5 EPAS1

1.36e-04188624449f9602df3c83b2110eb479a00d428d1b55b423
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

IGFBP3 MCAM IRS1 PRAG1

1.39e-041896240abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IGFBP3 MAP3K8 RET IL1R1

1.42e-041906241121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IGFBP3 MAP3K8 RET IL1R1

1.42e-04190624048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellfacs-Heart-LA-24m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPINT2 COMP MCAM EPAS1

1.42e-04190624911b93c4c828ef2d867b91a5eced2dc12a1baf27
ToppCellNS-critical-d_16-33-Epithelial-Secretory-diff|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.48e-0419262402b11233b4da2d85b96498b3c6e22e3a31b3d049
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPINT2 COMP HSPH1 CDC42EP5

1.51e-04193624d0a5f212f8e8a13dbbe3e41df92548ef82eef70b
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NBPF19 HMCN2 MAP3K8 IL1R1

1.51e-04193624b93f6af5999ad207fef5edc2bd900c7c6342f626
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN2 IGFBP3 CDC42EP5 EPAS1

1.51e-04193624cc355b2ed6510619cad969ae074126d7c8db784d
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGFBP3 COMP MCAM IRS1

1.51e-041936245de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPINT2 IGFBP3 CDC42EP5 IL1R1

1.54e-04194624855d6acfcf323868ba98b213f06186ad4793d4ed
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPINT2 IGFBP3 CDC42EP5 IL1R1

1.54e-04194624dc531cf9089f2c956621d70d49a2b8219b4b45c1
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPINT2 IGFBP3 CDC42EP5 IL1R1

1.54e-0419462429a7770bdbea6081a9ed64a997cd92a1cbf4af58
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPINT2 IGFBP3 CDC42EP5 IL1R1

1.54e-04194624ca051088f880154ae2fd3f0ab3cef5a8dba8c371
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

IGFBP3 IRS1 IL1R1 PRAG1

1.57e-04195624c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3PXD2A SLC30A8 HMGCR RET

1.57e-04195624bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell343B-Myeloid-Monocyte-CD14+_Monocyte|343B / Donor, Lineage, Cell class and subclass (all cells)

NBPF19 CD14 MAP3K8 HSPH1

1.57e-04195624b5ee368c97113432fc8fe742654cd538558f327c
ToppCell343B-Endothelial_cells-Endothelial-D|343B / Donor, Lineage, Cell class and subclass (all cells)

IGFBP3 MCAM IL1R1 EPAS1

1.60e-0419662499953fe0a40e242f6945150345fc0a08ed95f8f9
ToppCellFibroblasts-DKK3+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

THBS3 HMCN2 COMP LRRN2

1.60e-0419662424d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCellCOVID-mDC2|COVID / Condition, Cell_class and T cell subcluster

BTN2A2 SPINT2 MAP3K8 IL1R1

1.60e-04196624bb13926bb664be917017edb0ce7f184abe31744b
ToppCellCOVID-mDC2-|COVID / Condition, Cell_class and T cell subcluster

BTN2A2 SPINT2 MAP3K8 IL1R1

1.60e-041966246d02a4c5c19be7e036150cf945585cf5a773bc87
ToppCell343B-Endothelial_cells-Endothelial-D-|343B / Donor, Lineage, Cell class and subclass (all cells)

IGFBP3 MCAM IL1R1 EPAS1

1.60e-041966245edffdc4c1ff35d9ee0e5c1bed0dc0c90b76ea00
ToppCellCOPD-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

CD14 PCDH15 MCAM EPAS1

1.63e-0419762430dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCelldroplet-Heart-HEART|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP3 KLF13 SH3PXD2A IRS1

1.63e-041976249654472f1d4c9a6caadf1ff61a84902d171e9eb4
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGFBP3 ADAMTS7 LAMA5 IL1R1

1.63e-041976241da8ba5bbab232add6e43ad78b15c2339d0c2bc3
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGFBP3 LAMA5 IL1R1 EPAS1

1.63e-04197624d9e196c8b4a6ede4733946dbdba3331534954beb
ToppCelldroplet-Heart-HEART-1m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP3 KLF13 SH3PXD2A IRS1

1.63e-041976241ec3c05a5d4163df2cf0d168e28a3f1d35364da2
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPINT2 IGFBP3 LAMA5 EPAS1

1.66e-041986249718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell21-Trachea-Epithelial-Club-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

IGFBP3 MAP3K8 CDC42EP5 EPAS1

1.66e-04198624e735d82e5151c98b5724c543f8ad633c8ed824d2
ToppCellnormal_Lung-Endothelial_cells-Stalk-like_ECs|normal_Lung / Location, Cell class and cell subclass

IGFBP3 MCAM IL1R1 EPAS1

1.66e-041986242a251d13c2488d15ca9b11e643c1d17d428b6ef0
ToppCellBL-critical-LOC-Epithelial-Secretory_LYPD2|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.66e-04198624484d16aaa601a1e11b871b0475dd01a2de1a29ce
ToppCellNS-critical-LOC-Epithelial-Secretory_LYPD2|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.66e-041986244a481e1edb80b950c823ed926842cd5132cfb27f
ToppCellNS-moderate-d_07-13-Epithelial-Secretory-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.66e-04198624361f3062f73a0add16dd6fbe927698416515879f
ToppCellnucseq-Immune-Immune_Myeloid-iMON-iMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NBPF19 CD14 MAP3K8 NBPF14

1.66e-04198624e6dad9dea8cbd368b1b127572212cc913b909ffe
ToppCell21-Trachea-Epithelial-Basal_cell|Trachea / Age, Tissue, Lineage and Cell class

SPINT2 IGFBP3 LAMA5 EPAS1

1.66e-041986246ed75b53030028be915a90c0bca4d12e471914a5
ToppCellnucseq-Immune-Immune_Myeloid-iMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NBPF19 CD14 MAP3K8 NBPF14

1.66e-04198624bf5806424be33790f78f1c160398046a8725e469
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

IGFBP3 MCAM LAMA5 EPAS1

1.69e-04199624523e01f6a0abd9820697572e042a381aae8932dc
ToppCellBronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SH3PXD2A PCDHA12 IRS1 RET

1.69e-04199624a13f4b8a039304e685464cc8879659824cad5a3e
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGFBP3 MCAM LAMA5 EPAS1

1.69e-041996240d0d5cb821db16514192ad536849a8a04e22e637
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGFBP3 MCAM EPAS1 BGLAP

1.69e-04199624bd43a84e84d8acb8e1008b98a235cc5bd5f43586
ToppCellmLN-ILC-ILC|mLN / Region, Cell class and subclass

MAP3K8 MCAM IL1R1 EPAS1

1.69e-04199624ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCellmLN-ILC|mLN / Region, Cell class and subclass

MAP3K8 MCAM IL1R1 EPAS1

1.69e-04199624d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCellmLN-(3)_ILC|mLN / shred on region, Cell_type, and subtype

MAP3K8 MCAM IL1R1 EPAS1

1.69e-0419962400e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCellmLN-(3)_ILC-(30)_ILC|mLN / shred on region, Cell_type, and subtype

MAP3K8 MCAM IL1R1 EPAS1

1.69e-0419962433ac6d77099076df01299be429f4ba96f2f34cc1
ToppCellNS-moderate-d_16-33-Epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.69e-04199624aa2b51940115c22768c0d7493b4b60d41df3f376
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGFBP3 MCAM LAMA5 EPAS1

1.69e-04199624dfd60380a29f99e187050933ee5252ec11c68a32
ToppCellwk_20-22-Mesenchymal-Fibroblast-Adventitial_fibro|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

THBS3 HMCN2 IGFBP3 ADAMTSL4

1.69e-04199624ab0589c068c24aa989bdca083504fbad0c15221d
ToppCellmoderate-Epithelial-Secretory-diff|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.73e-042006246f29ef9dcf126c5c19386f6aa9a20c38a2c8ccc8
ToppCellmoderate-Epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.73e-04200624095783c9b75113ae350c2d5fb1195d71b41fa695
ToppCellNS-moderate-d_07-13-Epithelial|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.73e-0420062485940b4bf7971b872469dea8b8d7a45bdeb2a909
ToppCellTransplant_Alveoli_and_parenchyma-Endothelial-Endothelial|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

IGFBP3 MCAM IL1R1 EPAS1

1.73e-042006242ae62c428728c1d9d4471d4be24bd6ab074fa22c
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPINT2 SH3PXD2A LAMA5 EPAS1

1.73e-0420062497f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellLPS_IL1RA|World / Treatment groups by lineage, cell group, cell type

IGFBP3 CD14 HMGCR EPAS1

1.73e-04200624a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGFBP3 MCAM IL1R1 EPAS1

1.73e-04200624a1f5684fe3815642159dd201b7ecc39f09bee1e8
ToppCellNS-critical-d_07-13-Epithelial-Secretory-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.73e-042006246a76c8e3d937a9c54eb81cab23b8a898f9600de1
ToppCellNS-moderate-d_16-33-Epithelial-Secretory-diff|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.73e-042006248f179b5768fd504af6dd6f6749a0bed7b689e77f
ToppCellNS-critical-d_0-4-Epithelial-Secretory-diff|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.73e-04200624047e00f31ca744f82d61cac0e4e66563381f214b
ToppCellcritical-Epithelial-Secretory-diff|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPINT2 IGFBP3 CDC42EP5 EPAS1

1.73e-04200624407465404c5818bd2cd9d489bfbf29c3a55429d4
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MCAM LAMA5 IL1R1 EPAS1

1.73e-04200624a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCellSepsis-ICU-SEP-Myeloid-cDC2|ICU-SEP / Disease, condition lineage and cell class

TRAF3IP2 BTN2A2 SH3PXD2A NBPF1

1.73e-0420062409d5c3a3d2b42b15c769dc2bc14b6c0d5cc38f91
DrugPesticides

NBPF8 NBPF12 NBPF9 NBPF10 IRS1 ALB NBPF11 NBPF14 NBPF20 NBPF1

5.42e-121505910ctd:D010575
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

BTN2A2 THBS3 ZNF473 SH3PXD2A IRS1 EPAS1

1.20e-051975962702_DN
DrugLY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

THBS3 IGFBP3 ZNF473 ZNF174 LAMA5 MAP3K1

1.23e-05198596996_DN
DrugIopromide [73334-07-3]; Down 200; 5uM; MCF7; HT_HG-U133A

DGCR2 BTN2A2 IGFBP3 CTC1 ZNF174 TRIOBP

1.27e-051995963481_DN
Drugexenatide

SLC30A8 ALB BGLAP

1.56e-0519593ctd:C074031
Drugiodine

DGCR2 SPINT2 IGFBP3 ALB RET

1.82e-05125595CID000000807
Diseasehippocampus volume change measurement, age at assessment

DGCR2 KCNG1 PCDH15

2.05e-0529543EFO_0008007, EFO_0021492
Diseaseosteoporosis (is_marker_for)

IGFBP3 BGLAP

4.91e-056542DOID:11476 (is_marker_for)
Diseaseobstructive jaundice (biomarker_via_orthology)

CD14 ALB

1.47e-0410542DOID:13603 (biomarker_via_orthology)
Diseasecystic fibrosis (is_marker_for)

IGFBP3 CD14 BGLAP

2.03e-0462543DOID:1485 (is_marker_for)
Diseasewhite matter hyperintensity measurement

KLF13 SH3PXD2A PRAG1 PRDM15 MAP3K1

2.28e-04302545EFO_0005665
Diseasetype 2 diabetes mellitus (is_implicated_in)

IGFBP3 SLC30A8 IRS1 HMGCR

2.75e-04171544DOID:9352 (is_implicated_in)
Diseasebiliary atresia (is_marker_for)

SPINT2 CD14

2.95e-0414542DOID:13608 (is_marker_for)
Diseasetype 1 diabetes mellitus (is_marker_for)

IGFBP3 CD14 BGLAP

3.16e-0472543DOID:9744 (is_marker_for)
Diseasepolycystic kidney disease (biomarker_via_orthology)

EPAS1 BGLAP

5.51e-0419542DOID:0080322 (biomarker_via_orthology)
Diseaseend stage renal disease (implicated_via_orthology)

IRS1 HMGCR

6.12e-0420542DOID:783 (implicated_via_orthology)
Diseaseimpotence (biomarker_via_orthology)

IGFBP3 MCAM

7.42e-0422542DOID:1875 (biomarker_via_orthology)
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

RET EPAS1

8.11e-0423542C1708353
DiseaseBrain Diseases

CTC1 ALB

9.60e-0425542C0006111
Diseaseserum alanine aminotransferase measurement

SPINT2 KLF13 ADAMTS7 LAMA5 IL1R1 PRAG1 MAP3K1

9.96e-04869547EFO_0004735
Diseasemethionine measurement

CD14 PCDH15

1.04e-0326542EFO_0009771
DiseaseNephrotic Syndrome

LAMA5 ALB

1.12e-0327542C0027726
DiseaseEncephalopathies

CTC1 ALB

1.12e-0327542C0085584
DiseaseTYPE 2 DIABETES MELLITUS

SLC30A8 IRS1

1.21e-0328542125853
Diseasepneumonia (is_marker_for)

CD14 ALB

1.21e-0328542DOID:552 (is_marker_for)
DiseaseType 2 diabetes mellitus

SLC30A8 IRS1

1.21e-0328542cv:C0011860
Diseasehearing threshold measurement

ACTR5 LRRN2

1.21e-0328542EFO_0007618
Diseaseantipsychotic drug use measurement

ZNF473 KLF13

1.29e-0329542EFO_0007792
DiseaseMyopathy

HMGCR ALB

1.38e-0330542C0026848

Protein segments in the cluster

PeptideGeneStartEntry
CPEERLLAENPQSTP

EPAS1

546

Q99814
DDNPNLPRLVRPEVD

ALB

131

P02768
PEQPDPRALQCAAFN

ADAMTSL4

381

Q6UY14
SVQRAEEPRDLPDNP

BTN3A3

361

O00478
DNDPNRDEVPRAQLP

CXorf49;

396

A8MYA2
LEPPRLQRFQCGELP

CTC1

1171

Q2NKJ3
VPNEKDNCPLVRNPD

COMP

321

P49747
GVPDSRDNCRLVPNP

COMP

476

P49747
PEDRPLIVQFCANDP

DUS1L

71

Q6P1R4
QDPGPEPRLQFRAVC

ACTR5

51

Q9H9F9
IPRLICDPDPNCEIN

DEUP1

206

Q05D60
PEPQLRACELVQPNR

CDAN1

1206

Q8IWY9
RPDDQQRKCSEQPCP

ADAMTS7

866

Q9UKP4
RQRATPDAPPADLQD

DNAJC14

631

Q6Y2X3
NFDDNPLLRPPVEIC

LRRD1

726

A4D1F6
IELPREPRPNEECLQ

HMGCR

436

P04035
QEVRLDCEADGQPPP

HMCN2

3241

Q8NDA2
EPQSTLCAEPPDLQR

LRRN2

391

O75325
CLNQRPPENPDTDKN

HSPH1

516

Q92598
EALNPPREDQPRCQS

MAP3K8

386

P41279
RSPRPCLNIEDDPDI

FAM214A

846

Q32MH5
LRPQDEPRQGCQPED

KCNG1

46

Q9UIX4
RQDNSLPRPCPTEQL

LAMA5

1066

O15230
VRCPSQLQPAPREEE

IRS1

921

P35568
EDQGPPCPRLSRELL

NBPF1

1031

Q3BBV0
PLEPRREVCELNPDC

BGLAP

66

P02818
AIDQDRNIQPPSDRP

PCDH15

306

Q96QU1
QPRPSRLDLDLPGCQ

APC2

961

O95996
RLDLDLPGCQAEPPA

APC2

966

O95996
PEDLEQTQQRPLCPR

CEFIP

1211

Q711Q0
CNRLNRAPQPDELPE

CD14

306

P08571
GTQPPQARCRPNADL

CDC42EP5

126

Q6NZY7
TEPLRPELRCNPGQF

DGCR2

21

P98153
LNQQAPAPAPAERRE

KLF13

71

Q9Y2Y9
QRVPDNPERFDSQPC

BTN2A2

356

Q8WVV5
ANEIDVRPCPLNPNE

IL1R1

36

P14778
LQLSREDCLNPPSEP

PCDHA12

776

Q9UN75
GLRCQPSPDEARPLQ

IGFBP3

91

P17936
DRVEIRCLADGNPPP

MCAM

266

P43121
LRCLELQPQDRPPSR

MAP3K1

1486

Q13233
PPCLAQEGRYPRLEN

FOXL3

211

A0A1W2PRP0
PEPRALLNNEEPSQL

TOGARAM2

51

Q6ZUX3
DQGPPCPRLSRELLE

NBPF8

726

Q3BBV2
DQGPPCPRLSRELLE

NBPF9

761

P0DPF3
EGEENQNPPCPRLSR

NBPF9

851

P0DPF3
QNPPCPRLSRELLDE

NBPF9

856

P0DPF3
DQGPPCPRLSRELLE

NBPF10

761

Q6P3W6
EGEEDQNPPCPRLSR

NBPF10

851

Q6P3W6
QNPPCPRLSRELLDE

NBPF10

856

Q6P3W6
GEEDQNPPCPRLSRE

NBPF10

1096

Q6P3W6
EEDQNPPCPRLSREL

NBPF10

1341

Q6P3W6
EDQNPPCPRLSRELL

NBPF10

1586

Q6P3W6
EDQGPPCPRLSRELL

NBPF10

1736

Q6P3W6
DQNPPCPRLSRELLD

NBPF10

1831

Q6P3W6
DQGPPCPRLSRELLE

NBPF10

1981

Q6P3W6
EGEEDQNPPCPRLSR

NBPF10

2071

Q6P3W6
QNPPCPRLSRELLDE

NBPF10

2076

Q6P3W6
GEEDQNPPCPRLSRE

NBPF10

2316

Q6P3W6
EEDQNPPCPRLSREL

NBPF10

2561

Q6P3W6
EEDQGPPCPRLSREL

NBPF10

2711

Q6P3W6
EDQNPPCPRLSRELL

NBPF10

2806

Q6P3W6
EDQGPPCPRLSRELL

NBPF10

2956

Q6P3W6
DQNPPCPRLSRELLD

NBPF10

3051

Q6P3W6
EGEEDQNPPCPRLSR

NBPF10

3291

Q6P3W6
QNPPCPRLSRELLDE

NBPF10

3296

Q6P3W6
GEEDQNPPCPRLSRE

NBPF10

3536

Q6P3W6
EEDQNPPCPRLNGVL

NBPF10

3706

Q6P3W6
DQGPPCPRLSRELLE

NBPF11

761

Q86T75
EDQGPPCPRLSRELL

NBPF12

1031

Q5TAG4
DQNPPCPRLSRELLA

NBPF12

1126

Q5TAG4
DQGPPCPRLSRELLE

NBPF12

1276

Q5TAG4
DQGPPCPRLSRELLE

NBPF14

421

Q5TI25
EGEEDQNPPCPRLSR

NBPF14

511

Q5TI25
QNPPCPRLSRELLDE

NBPF14

516

Q5TI25
GEEDQNPPCPRLSRE

NBPF19

581

A0A087WUL8
EEDQNPPCPRLSREL

NBPF19

826

A0A087WUL8
EDQNPPCPRLSRELL

NBPF19

1071

A0A087WUL8
EDQDPPCPRLSRELV

NBPF19

1221

A0A087WUL8
DQNPPCPRLSRELLD

NBPF19

1316

A0A087WUL8
DQDPPCPRLSRELVE

NBPF19

1466

A0A087WUL8
EGEEDQNPPCPRLSR

NBPF19

1556

A0A087WUL8
QNPPCPRLSRELLDE

NBPF19

1561

A0A087WUL8
GEEDQNPPCPRLSRE

NBPF19

1801

A0A087WUL8
EEDQNPPCPRLSREL

NBPF19

2046

A0A087WUL8
EEDQGPPCPRLSREL

NBPF19

2196

A0A087WUL8
EDQNPPCPRLSRELL

NBPF19

2291

A0A087WUL8
EDQGPPCPRLSRELL

NBPF19

2441

A0A087WUL8
DQNPPCPRLSRELLD

NBPF19

2536

A0A087WUL8
DQGPPCPRLSRELLE

NBPF19

2686

A0A087WUL8
EGEEDQNPPCPRLSR

NBPF19

2776

A0A087WUL8
QNPPCPRLSRELLDE

NBPF19

2781

A0A087WUL8
GEEDQNPPCPRLSRE

NBPF19

3021

A0A087WUL8
EEDQNPPCPRLSREL

NBPF19

3266

A0A087WUL8
EEDQGPPCPRLSREL

NBPF19

3416

A0A087WUL8
EDQNPPCPRLSRELL

NBPF19

3511

A0A087WUL8
EDQGPPCPRLSRELL

NBPF19

3661

A0A087WUL8
DQGPPCPRLSRELLE

NBPF20

146

P0DPF2
EGEEDQNPPCPRLSR

NBPF20

236

P0DPF2
QNPPCPRLSRELLDE

NBPF20

241

P0DPF2
GEEDQNPPCPRLSRE

NBPF20

481

P0DPF2
EEDQNPPCPRLSREL

NBPF20

726

P0DPF2
EEDQGPPCPRLSREL

NBPF20

876

P0DPF2
EDQNPPCPRLSRELL

NBPF20

971

P0DPF2
EDQGPPCPRLSRELL

NBPF20

1121

P0DPF2
DQNPPCPRLSRELLD

NBPF20

1216

P0DPF2
DQGPPCPRLSRELLE

NBPF20

1366

P0DPF2
GEEDQNPPCPRLSRE

NBPF20

1701

P0DPF2
EEDQNPPCPRLSREL

NBPF20

1946

P0DPF2
EEDQGPPCPRLSREL

NBPF20

2096

P0DPF2
EDQNPPCPRLSRELL

NBPF20

2191

P0DPF2
EDQGPPCPRLSRELL

NBPF20

2341

P0DPF2
DQNPPCPRLSRELLD

NBPF20

2436

P0DPF2
DQGPPCPRLSRELLE

NBPF20

2586

P0DPF2
EGEEDQNPPCPRLSR

NBPF20

2676

P0DPF2
QNPPCPRLSRELLDE

NBPF20

2681

P0DPF2
GEEDQNPPCPRLSRE

NBPF20

2921

P0DPF2
EEDQNPPCPRLSREL

NBPF20

3166

P0DPF2
EEDQGPPCPRLSREL

NBPF20

3316

P0DPF2
EDQNPPCPRLSRELL

NBPF20

3411

P0DPF2
EDQGPPCPRLSRELL

NBPF20

3561

P0DPF2
DQNPPCPRLSRELLD

NBPF20

3656

P0DPF2
DQGPPCPRLSRELLE

NBPF20

3806

P0DPF2
EGEEDQNPPCPRLSR

NBPF20

3896

P0DPF2
QNPPCPRLSRELLDE

NBPF20

3901

P0DPF2
EEDQNPPCPRLSREL

NBPF20

4386

P0DPF2
EEDQGPPCPRLSREL

NBPF20

4461

P0DPF2
EDQNPPCPRLSRELL

NBPF20

4556

P0DPF2
EDQGPPCPRLSRELL

NBPF20

4631

P0DPF2
EDQGPPCPRLSRELL

NBPF20

4781

P0DPF2
DQNPPCPRLSRELLD

NBPF20

4876

P0DPF2
DQGPPCPRLSRELLE

NBPF20

5026

P0DPF2
QEVEEDQNPPCPRLS

NBPF26

341

B4DH59
DQNPPCPRLSRELLD

NBPF26

346

B4DH59
DQGPPCPRLSRELLE

NBPF26

721

B4DH59
RDRADPQQLPEAVPA

PRDM15

366

P57071
ENPRTPCVQQDDPRA

TRIOBP

376

Q9H2D6
ESLECPAELRPQVPQ

TRAF3IP2

366

O43734
PVNKDQCPRERPEEL

SLC30A8

31

Q8IWU4
QELPDFQPQTPRRDL

ZNF174

156

Q15697
PPPKDNNLSCALRRN

SH3PXD2A

986

Q5TCZ1
LRCFRQQENPPLPLG

SPINT2

181

O43291
NEPPRLNASPAAREE

TCF20

566

Q9UGU0
PLGNDCPEQDRLPQR

UBIAD1

26

Q9Y5Z9
DNCPKVPNPLQTDRD

THBS3

576

P49746
PPRPENCRLEDEGVN

PRAG1

61

Q86YV5
EETPLVDCNNAPLPR

RET

1036

P07949
ELLQEPCGQRDSPPD

SH2D4B

411

Q5SQS7
EDPECVLPQEAFPLR

WDR24

561

Q96S15
NRDPARPEECNLIEG

PPIP5K1

166

Q6PFW1
LDNCQDLFLLDPPRP

ZNF473

36

Q8WTR7