Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of extracellular matrix constituent secretion

CPB2 TNFRSF1B NOTCH1

3.37e-0610643GO:0003330
GeneOntologyBiologicalProcessregulation of extracellular matrix organization

EFEMP2 LRP1 CPB2 TNFRSF1B NOTCH1

6.27e-0684645GO:1903053
GeneOntologyBiologicalProcessextracellular matrix constituent secretion

CPB2 TNFRSF1B NOTCH1

1.26e-0515643GO:0070278
GeneOntologyBiologicalProcessglial cell-neuron signaling

WNT1 TNFRSF1B

5.66e-054642GO:0150098
GeneOntologyBiologicalProcessnegative regulation of extracellular matrix constituent secretion

TNFRSF1B NOTCH1

5.66e-054642GO:0003332
GeneOntologyBiologicalProcessnegative regulation of cell-substrate adhesion

FBLN1 WNT1 LRP1 NOTCH1

8.24e-0574644GO:0010812
GeneOntologyBiologicalProcesstissue morphogenesis

SPRY1 FLNA TRIM28 WNT1 EFEMP2 SCNN1G LRP5 LY6E RNF207 NOTCH1

9.75e-057506410GO:0048729
GeneOntologyBiologicalProcessapoptotic process involved in morphogenesis

LRP5 TNFRSF1B NOTCH1

1.33e-0432643GO:0060561
GeneOntologyBiologicalProcessregulation of cell-substrate adhesion

FLNA FBLN1 WNT1 EFEMP2 LRP1 NOTCH1

1.36e-04254646GO:0010810
GeneOntologyBiologicalProcessresponse to glucose

PCSK1 PDE3B PDE8B LRP1 LRP5 CPB2

1.54e-04260646GO:0009749
GeneOntologyBiologicalProcesspositive regulation of osteoblast differentiation

BMPR1B FBN2 LRP5 SUCO

1.62e-0488644GO:0045669
GeneOntologyBiologicalProcessextracellular matrix organization

FBLN1 EFEMP2 LRP1 CPB2 TNFRSF1B MMP17 NOTCH1

1.64e-04377647GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

FBLN1 EFEMP2 LRP1 CPB2 TNFRSF1B MMP17 NOTCH1

1.66e-04378647GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

FBLN1 EFEMP2 LRP1 CPB2 TNFRSF1B MMP17 NOTCH1

1.69e-04379647GO:0045229
GeneOntologyBiologicalProcessresponse to hexose

PCSK1 PDE3B PDE8B LRP1 LRP5 CPB2

1.71e-04265646GO:0009746
GeneOntologyBiologicalProcessregulation of insulin secretion involved in cellular response to glucose stimulus

PDE3B PDE8B LRP1 LRP5

1.92e-0492644GO:0061178
GeneOntologyBiologicalProcessresponse to monosaccharide

PCSK1 PDE3B PDE8B LRP1 LRP5 CPB2

1.97e-04272646GO:0034284
GeneOntologyBiologicalProcesspositive regulation of apoptotic process involved in morphogenesis

TNFRSF1B NOTCH1

1.97e-047642GO:1902339
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

SPRY1 BMPR1B FBN2 WNT1 LRP1 ITGB6

2.13e-04276646GO:0007179
GeneOntologyBiologicalProcessregulation of establishment of protein localization

PCSK1 FLNA VPS11 PDE3B TRIM28 PDE8B LRP1 LRP5 GDI1

2.23e-04674649GO:0070201
GeneOntologyBiologicalProcesspositive regulation of apoptotic process involved in development

TNFRSF1B NOTCH1

2.62e-048642GO:1904747
GeneOntologyBiologicalProcessregulation of membrane repolarization during cardiac muscle cell action potential

FLNA RNF207

2.62e-048642GO:1905031
GeneOntologyBiologicalProcesscell-substrate adhesion

FLNA FBLN1 WNT1 EFEMP2 LRP1 ITGB6 NOTCH1

2.73e-04410647GO:0031589
GeneOntologyBiologicalProcessaorta morphogenesis

EFEMP2 LRP1 NOTCH1

2.79e-0441643GO:0035909
GeneOntologyBiologicalProcessinsulin secretion involved in cellular response to glucose stimulus

PDE3B PDE8B LRP1 LRP5

2.85e-04102644GO:0035773
GeneOntologyBiologicalProcessregulation of osteoblast differentiation

BMPR1B FBN2 LRP5 SUCO NOTCH1

3.24e-04192645GO:0045667
GeneOntologyBiologicalProcessresponse to carbohydrate

PCSK1 PDE3B PDE8B LRP1 LRP5 CPB2

3.39e-04301646GO:0009743
GeneOntologyBiologicalProcesscellular response to glucose stimulus

PDE3B PDE8B LRP1 LRP5 CPB2

3.56e-04196645GO:0071333
GeneOntologyBiologicalProcesscellular response to hexose stimulus

PDE3B PDE8B LRP1 LRP5 CPB2

3.82e-04199645GO:0071331
GeneOntologyBiologicalProcesscellular response to monosaccharide stimulus

PDE3B PDE8B LRP1 LRP5 CPB2

4.00e-04201645GO:0071326
GeneOntologyBiologicalProcessapoptotic process involved in development

LRP5 TNFRSF1B NOTCH1

4.19e-0447643GO:1902742
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

SPRY1 BMPR1B FBN2 WNT1 LRP1 ITGB6 NOTCH1

4.47e-04445647GO:0141091
GeneOntologyBiologicalProcessanimal organ morphogenesis

SPRY1 FLNA BMPR1B FBN2 WNT1 EFEMP2 LRP5 CPB2 LY6E RNF207 ITGB6 NOTCH1

4.65e-0412696412GO:0009887
GeneOntologyBiologicalProcessregulation of protein localization

PCSK1 FLNA VPS11 PDE3B CELSR2 TRIM28 PDE8B TMEM59 LRP1 LRP5 GDI1

4.70e-0410876411GO:0032880
GeneOntologyBiologicalProcessregulation of membrane repolarization during action potential

FLNA RNF207

5.12e-0411642GO:0098903
GeneOntologyBiologicalProcessregulation of cell adhesion

SELE FLNA FBLN1 CXCR3 PDE3B CELSR2 WNT1 EFEMP2 LRP1 NOTCH1

5.34e-049276410GO:0030155
GeneOntologyBiologicalProcesscellular response to carbohydrate stimulus

PDE3B PDE8B LRP1 LRP5 CPB2

5.43e-04215645GO:0071322
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

SPRY1 FBN2 WNT1 LRP1 NOTCH1

5.79e-04218645GO:0090101
GeneOntologyBiologicalProcessintracellular glucose homeostasis

PDE3B PDE8B LRP1 LRP5 CPB2

5.79e-04218645GO:0001678
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

SPRY1 BMPR1B FBN2 WNT1 LRP1 ITGB6

6.05e-04336646GO:0071560
GeneOntologyBiologicalProcessglucose homeostasis

PDE3B FBN2 PDE8B LRP1 LRP5 CPB2

6.24e-04338646GO:0042593
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

SPRY1 FLNA TRIM28 WNT1 SCNN1G LRP5 RNF207 NOTCH1

6.33e-04619648GO:0002009
GeneOntologyBiologicalProcesscarbohydrate homeostasis

PDE3B FBN2 PDE8B LRP1 LRP5 CPB2

6.34e-04339646GO:0033500
GeneOntologyBiologicalProcesscilium organization

FSIP2 FLNA CELSR2 SSX2IP LCA5L WDR90 NOTCH1

6.66e-04476647GO:0044782
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

SPRY1 BMPR1B FBN2 WNT1 LRP1 ITGB6

6.74e-04343646GO:0071559
GeneOntologyBiologicalProcessregionalization

SPRY1 BMPR1B CELSR2 WNT1 LRP5 RNF207 NOTCH1

6.83e-04478647GO:0003002
GeneOntologyBiologicalProcessorganelle assembly

FSIP2 FLNA VPS11 CELSR2 SSX2IP PRICKLE2 WDR90 SRPX MAP10 NOTCH1 KNL1

6.90e-0411386411GO:0070925
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

SPRY1 BMPR1B FBN2 WNT1 LRP1 ITGB6 NOTCH1

7.17e-04482647GO:0007178
GeneOntologyBiologicalProcessnegative regulation of transforming growth factor beta receptor signaling pathway

SPRY1 FBN2 WNT1 LRP1

8.93e-04138644GO:0030512
GeneOntologyBiologicalProcessvascular associated smooth muscle cell development

EFEMP2 NOTCH1

9.70e-0415642GO:0097084
GeneOntologyBiologicalProcessregulation of apoptotic process involved in morphogenesis

TNFRSF1B NOTCH1

9.70e-0415642GO:1902337
GeneOntologyBiologicalProcessregeneration

FLNA WNT1 LRP1 CPB2 NOTCH1

1.11e-03252645GO:0031099
GeneOntologyBiologicalProcessregulation of cellular localization

PCSK1 FLNA VPS11 PDE3B CELSR2 TRIM28 PDE8B TMEM59 LRP1 LRP5 GDI1

1.16e-0312126411GO:0060341
GeneOntologyBiologicalProcesspattern specification process

SPRY1 BMPR1B CELSR2 WNT1 LRP5 RNF207 NOTCH1

1.19e-03526647GO:0007389
GeneOntologyBiologicalProcesssecretion

PCSK1 VPS11 PDE3B CELSR2 PDE8B LRP1 LRP5 CPB2 TNFRSF1B LY6E NOTCH1

1.23e-0312216411GO:0046903
GeneOntologyBiologicalProcessregulation of apoptotic process involved in development

TNFRSF1B NOTCH1

1.25e-0317642GO:1904748
GeneOntologyBiologicalProcessnegative regulation of insulin secretion involved in cellular response to glucose stimulus

PDE3B PDE8B

1.25e-0317642GO:0061179
GeneOntologyBiologicalProcesspositive regulation of axon regeneration

FLNA LRP1

1.25e-0317642GO:0048680
GeneOntologyBiologicalProcessblood coagulation, fibrin clot formation

FLNA FBLN1

1.25e-0317642GO:0072378
GeneOntologyCellularComponentelastic fiber

FBLN1 EFEMP2

9.46e-055652GO:0071953
GeneOntologyCellularComponentreceptor complex

FLNA BMPR1B LRP1 GPR156 LRP5 TNFRSF1B ITGB6 NOTCH1

4.25e-04581658GO:0043235
GeneOntologyCellularComponentperinuclear region of cytoplasm

SELE PCSK1 USP2 FLNA TRPC4AP PDE8B LRP1 TNFRSF1B RNF207 MOB2

5.80e-049346510GO:0048471
GeneOntologyCellularComponentmicrofibril

FBN2 EFEMP2

7.26e-0413652GO:0001527
HumanPhenoAbnormal metatarsal ossification

FLNA LRP5

1.62e-052212HP:0008371
DomainEGF_3

SELE FBLN1 CNTNAP5 FBN2 CELSR2 ADAM18 EFEMP2 DNER LRP1 LRP5 ADGRE5 NOTCH1

2.19e-112356412PS50026
DomainEGF-like_dom

SELE FBLN1 CNTNAP5 FBN2 CELSR2 ADAM18 EFEMP2 DNER LRP1 LRP5 ADGRE5 NOTCH1

4.30e-112496412IPR000742
DomainEGF_1

SELE FBLN1 CNTNAP5 FBN2 CELSR2 ADAM18 EFEMP2 DNER LRP1 LRP5 ITGB6 NOTCH1

5.67e-112556412PS00022
DomainEGF_2

SELE FBLN1 CNTNAP5 FBN2 CELSR2 ADAM18 EFEMP2 DNER LRP1 LRP5 ITGB6 NOTCH1

8.86e-112656412PS01186
DomainEGF-like_Ca-bd_dom

FBLN1 FBN2 CELSR2 EFEMP2 DNER LRP1 LRP5 ADGRE5 NOTCH1

3.78e-10124649IPR001881
DomainEGF

SELE FBLN1 CNTNAP5 FBN2 CELSR2 EFEMP2 DNER LRP1 LRP5 ADGRE5 NOTCH1

4.10e-102356411SM00181
DomainEGF-like_CS

SELE FBLN1 FBN2 CELSR2 ADAM18 EFEMP2 DNER LRP1 LRP5 ITGB6 NOTCH1

1.24e-092616411IPR013032
DomainEGF_CA

FBLN1 FBN2 EFEMP2 DNER LRP1 LRP5 ADGRE5 NOTCH1

1.62e-0999648PS01187
DomainASX_HYDROXYL

FBLN1 FBN2 CELSR2 EFEMP2 DNER LRP1 ADGRE5 NOTCH1

1.76e-09100648PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN1 FBN2 CELSR2 EFEMP2 DNER LRP1 ADGRE5 NOTCH1

2.80e-09106648IPR000152
DomainEGF_CA

FBLN1 FBN2 CELSR2 EFEMP2 DNER LRP1 ADGRE5 NOTCH1

8.57e-09122648SM00179
DomainEGF_Ca-bd_CS

FBLN1 FBN2 EFEMP2 DNER LRP1 ADGRE5 NOTCH1

3.99e-0897647IPR018097
DomainGrowth_fac_rcpt_

FBLN1 FBN2 CELSR2 EFEMP2 DNER LRP1 ADGRE5 NOTCH1

5.89e-08156648IPR009030
DomainEGF_CA

FBLN1 FBN2 EFEMP2 LRP1 ADGRE5 NOTCH1

4.83e-0786646PF07645
DomaincEGF

FBLN1 FBN2 EFEMP2 LRP1

1.77e-0626644IPR026823
DomaincEGF

FBLN1 FBN2 EFEMP2 LRP1

1.77e-0626644PF12662
DomainhEGF

FBN2 CELSR2 DNER NOTCH1

2.41e-0628644PF12661
DomainEGF

SELE CELSR2 DNER LRP1 LRP5 NOTCH1

4.55e-06126646PF00008
DomainEGF_extracell

ADAM18 DNER ITGB6 NOTCH1

5.29e-0560644IPR013111
DomainEGF_2

ADAM18 DNER ITGB6 NOTCH1

5.29e-0560644PF07974
DomainLdl_recept_b

LRP1 LRP5

1.02e-0314642PF00058
DomainLDLRB

LRP1 LRP5

1.02e-0314642PS51120
DomainLY

LRP1 LRP5

1.18e-0315642SM00135
DomainLDLR_classB_rpt

LRP1 LRP5

1.18e-0315642IPR000033
DomainPropept_inh

PCSK1 CPB2

1.52e-0317642IPR009020
Domain-

PCSK1 CNTNAP5 SUCO

2.01e-03736432.60.120.260
DomainPDEase_I

PDE3B PDE8B

2.33e-0321642PF00233
DomainPDEASE_I

PDE3B PDE8B

2.33e-0321642PS00126
DomainPDEase_CS

PDE3B PDE8B

2.33e-0321642IPR023174
Domain-

PDE3B PDE8B

2.55e-03226421.10.1300.10
DomainPDEase_catalytic_dom

PDE3B PDE8B

2.79e-0323642IPR002073
DomainHDc

PDE3B PDE8B

3.04e-0324642SM00471
DomainHD/PDEase_dom

PDE3B PDE8B

3.04e-0324642IPR003607
DomainTNFR

CELSR2 TNFRSF1B

3.56e-0326642SM00208
DomainGalactose-bd-like

PCSK1 CNTNAP5 SUCO

4.12e-0394643IPR008979
DomainTNFR/NGFR_Cys_rich_reg

CELSR2 TNFRSF1B

5.70e-0333642IPR001368
DomainGPS

CELSR2 ADGRE5

6.04e-0334642SM00303
DomainGPS

CELSR2 ADGRE5

6.39e-0335642PF01825
DomainGPS

CELSR2 ADGRE5

6.76e-0336642PS50221
DomainGPS

CELSR2 ADGRE5

7.13e-0337642IPR000203
Domainzf-C3HC4

VPS11 TRIM28 MARCHF8 RNF207

7.19e-03223644PF00097
DomainLAM_G_DOMAIN

CNTNAP5 CELSR2

7.51e-0338642PS50025
DomainKeratin_B2_2

KRTAP10-10 KRTAP10-9

7.89e-0339642PF13885
Domain-

LRP1 LRP5

7.89e-03396422.120.10.30
DomainLDLR_class-A_CS

LRP1 LRP5

8.29e-0340642IPR023415
DomainKeratin_B2

KRTAP10-10 KRTAP10-9

8.29e-0340642PF01500
DomainLaminin_G_2

CNTNAP5 CELSR2

8.29e-0340642PF02210
DomainLamG

CNTNAP5 CELSR2

9.97e-0344642SM00282
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN1 FBN2 EFEMP2 ITGB6

7.19e-0637484M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN1 FBN2 EFEMP2 ITGB6

1.45e-0544484M26969
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN2 EFEMP2 ITGB6

1.71e-0432483MM14854
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN2 EFEMP2 ITGB6

3.11e-0439483MM14601
Pubmed

Heritable Thoracic Aortic Disease Overview

FLNA FBN2 EFEMP2 NOTCH1

3.12e-073066420301299
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FBLN1 FBN2 CELSR2 TRIM28 DIPK1A TMEM59 DNER LRP1 LRP5 ADGRE5 SUCO NOTCH1

2.39e-061201661235696571
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

SPRY1 FBLN1 EFEMP2 LRP1 NOTCH1

3.13e-0611866521078624
Pubmed

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.

WNT1 NOTCH1

3.55e-06266216501043
Pubmed

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis.

WNT1 LRP5

3.55e-06266216973609
Pubmed

NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

PRAG1 NOTCH1

3.55e-06266225038227
Pubmed

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.

CELSR2 WNT1 PRICKLE2 LRP5

6.90e-066466424431302
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN2 LRP1 MED13L MUC5AC

1.04e-057166433541421
Pubmed

MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways.

MUC5AC NOTCH1

1.06e-05366221622856
Pubmed

Regulation of intestinal cancer stem cells.

WNT1 NOTCH1

1.06e-05366222546285
Pubmed

Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells.

WNT1 NOTCH1

1.06e-05366226735577
Pubmed

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor.

WNT1 LRP5

1.06e-05366211956231
Pubmed

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand.

WNT1 LRP5

1.06e-05366230404864
Pubmed

Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway.

WNT1 NOTCH1

1.06e-05366222954590
Pubmed

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development.

FBLN1 FBN2 TNFRSF1B NOTCH1

1.10e-057266437702066
Pubmed

Primary cilia in murine palatal rugae development.

CELSR2 WNT1 NOTCH1

1.12e-052366331226309
Pubmed

Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice.

FBLN1 EFEMP2

2.12e-05466226711913
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

LRP1 LRP5

2.12e-0546627775583
Pubmed

Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.

WNT1 LRP5

2.12e-05466222696217
Pubmed

The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells.

FLNA LRP1

2.12e-05466227522265
Pubmed

Tripartite motif-containing 28 bridges endothelial inflammation and angiogenic activity by retaining expression of TNFR-1 and -2 and VEGFR2 in endothelial cells.

TRIM28 TNFRSF1B

2.12e-05466228159803
Pubmed

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

WNT1 LRP5

2.12e-05466211336703
Pubmed

Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection.

WNT1 NOTCH1

2.12e-05466222710872
Pubmed

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.

WNT1 LRP5

2.12e-05466215064719
Pubmed

Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner.

SELE LRP1

2.12e-05466215591119
Pubmed

Arachidonic acid potentiates hypoxia-induced VEGF expression in mouse embryonic stem cells: involvement of Notch, Wnt, and HIF-1alpha.

WNT1 NOTCH1

2.12e-05466219339510
Pubmed

The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury.

LRP1 TNFRSF1B

2.12e-05466217065459
Pubmed

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

WNT1 LRP5

3.53e-05566211448771
Pubmed

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

USP2 SCNN1G

3.53e-05566221478478
Pubmed

Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications.

WNT1 NOTCH1

3.53e-05566222123293
Pubmed

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways.

WNT1 NOTCH1

3.53e-05566226592459
Pubmed

LDL-receptor-related proteins in Wnt signal transduction.

WNT1 LRP5

3.53e-05566211029007
Pubmed

Deubiquitinase USP10 regulates Notch signaling in the endothelium.

USP2 NOTCH1

3.53e-05566230975888
Pubmed

A mouse model of lethal synergism between influenza virus and Haemophilus influenzae.

CXCR3 TNFRSF1B

3.53e-05566220042666
Pubmed

Chimeric analysis of Notch2 function: a role for Notch2 in the development of the roof plate of the mouse brain.

WNT1 NOTCH1

3.53e-05566212242712
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN2 EFEMP2

3.53e-05566217255108
Pubmed

Deubiquitylation regulates activation and proteolytic cleavage of ENaC.

USP2 SCNN1G

3.53e-05566218701608
Pubmed

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.

WNT1 LRP5

3.53e-05566212121999
Pubmed

The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.

LRP1 MMP17

5.29e-05666214645246
Pubmed

The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus.

CXCR3 TNFRSF1B

5.29e-05666227663205
Pubmed

Molecular evolution of the fibulins: implications on the functionality of the elastic fibulins.

FBLN1 EFEMP2

5.29e-05666220595023
Pubmed

Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.

CELSR2 PRICKLE2

7.40e-05766217937400
Pubmed

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.

SELE FLNA

7.40e-0576628609175
Pubmed

DNER acts as a neuron-specific Notch ligand during Bergmann glial development.

DNER NOTCH1

7.40e-05766215965470
Pubmed

ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy.

LRP1 CPB2

9.86e-05866220381197
Pubmed

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

WNT1 LRP5

9.86e-05866215035989
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

CELSR2 WNT1 PRICKLE2

9.97e-054766333141892
Pubmed

Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).

FLNA FBLN1 FBN2 SRPX TNFRSF1B

1.09e-0424766539238192
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBLN1 FBN2

1.27e-04966212122015
Pubmed

Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins.

SPRY1 WNT1

1.27e-04966217537797
Pubmed

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.

TMEM59 NOTCH1

1.27e-04966215574878
Pubmed

Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.

FLNA ITGB6

1.27e-04966211807098
Pubmed

An LDL-receptor-related protein mediates Wnt signalling in mice.

WNT1 LRP5

1.27e-04966211029008
Pubmed

New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.

SPRY1 WNT1

1.27e-04966215790971
Pubmed

Functional proteomics mapping of a human signaling pathway.

FLNA FBLN1 FBN2 ZFYVE16 LRP1 LRP5 KNL1

1.29e-0459166715231748
Pubmed

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.

WNT1 LRP5

1.58e-041066215143170
Pubmed

Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development.

WNT1 NOTCH1

1.58e-041066221147849
Pubmed

Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.

TNFRSF1B NOTCH1

1.58e-041066234519339
Pubmed

Genome-wide association analysis identifies susceptibility loci for migraine without aura.

LRP1 MMP17

1.58e-041066222683712
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

CXCR3 DRICH1 JCHAIN DNER ADGRE5 TNFRSF1B LY6E ITGB6

1.64e-0482466820237496
Pubmed

Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons.

BMPR1B WNT1

1.93e-041166221394823
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP5

1.93e-041166224639464
Pubmed

Endofin acts as a Smad anchor for receptor activation in BMP signaling.

BMPR1B ZFYVE16

1.93e-041166217356069
Pubmed

Sequential actions of BMP receptors control neural precursor cell production and fate.

BMPR1B WNT1

1.93e-041166211511541
Pubmed

Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.

KRTAP10-10 KRTAP10-9

1.93e-041166214962103
Pubmed

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

TNFRSF1B NOTCH1

1.93e-041166226491108
Pubmed

Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum.

SPRY1 WNT1

1.93e-041166219968985
Pubmed

Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer.

SPRY1 WNT1

2.31e-041266216530751
Pubmed

The importance of Wnt signalling for neurodegeneration in Parkinson's disease.

WNT1 LRP5

2.31e-041266222988876
Pubmed

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

MUC5AC NOTCH1

2.31e-041266219369400
Pubmed

Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.

WNT1 LRP5

2.31e-041266227864382
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FLNA CELSR2 TRIM28 LRP5 WDR90 MED13L MMP17 PRAG1 NOTCH1

2.33e-04110566935748872
Pubmed

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

CELSR2 PRICKLE2

2.73e-041366226989192
Pubmed

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.

WNT1 LRP1

2.73e-041366216207730
Pubmed

KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.

TNFRSF1B NOTCH1

3.18e-041466225401743
Pubmed

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.

WNT1 NOTCH1

3.18e-041466210090727
Pubmed

Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.

LRP1 ADGRE5

3.18e-041466219299737
Pubmed

Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

FLNA GDI1

3.18e-04146628733135
Pubmed

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.

MUC5AC NOTCH1

3.18e-041466222797898
Pubmed

BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.

BMPR1B NOTCH1

3.67e-041566216324690
Pubmed

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.

MED13L NOTCH1

3.67e-041566231285543
Pubmed

The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.

TRIM28 NOTCH1

3.67e-041566226522984
Pubmed

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

SELE SCNN1G

4.18e-041666210391210
Pubmed

Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.

SPRY1 WNT1

4.18e-041666221925158
Pubmed

A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.

KRTAP10-10 KRTAP10-9

4.18e-041666215028290
Pubmed

Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.

SPRY1 WNT1

4.18e-041666218216176
Pubmed

Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.

LRP5 NOTCH1

4.18e-041666219154719
Pubmed

Fgfr1-dependent boundary cells between developing mid- and hindbrain.

SPRY1 WNT1

4.18e-041666215680361
Pubmed

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.

SPRY1 WNT1

4.74e-041766216571630
Pubmed

Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

ZNF19 ZNF154

4.74e-04176627557990
Pubmed

Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.

SPRY1 WNT1

4.74e-041766226443994
Pubmed

A threshold requirement for Gbx2 levels in hindbrain development.

SPRY1 WNT1

4.74e-041766216651541
Pubmed

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.

SPRY1 WNT1

5.32e-041866212682014
Pubmed

Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.

BMPR1B WNT1

5.32e-041866231869353
Pubmed

Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6.

USP2 VPS11

5.32e-041866212140190
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

CNTNAP5 ZNF804B DNER PRICKLE2

5.68e-0419966423382691
Pubmed

Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway.

MUC5AC NOTCH1

5.94e-041966227122169
Pubmed

The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.

WNT1 NOTCH1

5.94e-041966220627076
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

FBLN1 FBN2 EFEMP2

5.97e-048666328327460
Pubmed

Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.

BMPR1B TRIM28 NOTCH1

7.04e-049166321194568
InteractionZNF417 interactions

SPRY1 ZNF19 ZNF165 TRIM28 SSX2IP KRTAP10-9 ZNF774

1.87e-06178667int:ZNF417
InteractionZNF587 interactions

TRIM28 KRTAP10-10 EFEMP2 SSX2IP KRTAP10-9 ZNF774

5.28e-06135666int:ZNF587
InteractionLCE1C interactions

SPRY1 FBLN1 KRTAP10-10 EFEMP2 KRTAP10-9

5.32e-0677665int:LCE1C
InteractionZNF699 interactions

TRIM28 EFEMP2 KRTAP10-9

1.19e-0514663int:ZNF699
InteractionCSNK1A1L interactions

LRP5 ZDBF2 TNFRSF1B FAM170A

3.90e-0558664int:CSNK1A1L
InteractionCACNA1A interactions

SPRY1 FBLN1 EFEMP2 LRP1 NOTCH1

5.18e-05123665int:CACNA1A
InteractionLCE3C interactions

SPRY1 KRTAP10-10 EFEMP2 KRTAP10-9

6.89e-0567664int:LCE3C
InteractionLCE1E interactions

SPRY1 KRTAP10-10 EFEMP2 KRTAP10-9

7.30e-0568664int:LCE1E
InteractionFAM124B interactions

EFEMP2 SSX2IP KRTAP10-9 ZNF774

9.63e-0573664int:FAM124B
InteractionIGFL3 interactions

FBLN1 FBN2 LRP5 NOTCH1

1.07e-0475664int:IGFL3
InteractionLCE3A interactions

SPRY1 FBLN1 EFEMP2 KRTAP10-9

1.13e-0476664int:LCE3A
InteractionTRIM42 interactions

CERK FBLN1 EFEMP2 SSX2IP KRTAP10-9

1.28e-04149665int:TRIM42
InteractionZNF774 interactions

ZNF165 EFEMP2 KRTAP10-9 ZNF774

1.31e-0479664int:ZNF774
InteractionZNF837 interactions

SPRY1 ZNF165 EFEMP2 KRTAP10-9

1.31e-0479664int:ZNF837
InteractionDKK1 interactions

FBLN1 WNT1 LRP5

1.55e-0432663int:DKK1
InteractionHOXA1 interactions

SPRY1 FBLN1 KRTAP10-10 EFEMP2 KRTAP10-9 ZNF774 NOTCH1

1.61e-04356667int:HOXA1
InteractionLCE1A interactions

SPRY1 FBLN1 EFEMP2 KRTAP10-9

1.66e-0484664int:LCE1A
InteractionKAT5 interactions

FLNA TRIM28 SSX2IP LRP1 GPR156 KRTAP10-9 NOTCH1

1.67e-04358667int:KAT5
InteractionLCE1B interactions

SPRY1 FBLN1 KRTAP10-10 KRTAP10-9

1.74e-0485664int:LCE1B
InteractionLCE2C interactions

SPRY1 KRTAP10-10 EFEMP2 KRTAP10-9

1.99e-0488664int:LCE2C
InteractionCREB5 interactions

SPRY1 FBLN1 KRTAP10-10 EFEMP2 KRTAP10-9

2.01e-04164665int:CREB5
InteractionLCE1F interactions

SPRY1 FBLN1 KRTAP10-10 KRTAP10-9

2.36e-0492664int:LCE1F
GeneFamilyFibulins

FBLN1 EFEMP2

1.68e-048452556
GeneFamilyADAM metallopeptidase domain containing|CD molecules

SELE CXCR3 BMPR1B LRP1 ADGRE5 TNFRSF1B

4.09e-04394456471
GeneFamilyLow density lipoprotein receptors

LRP1 LRP5

4.64e-0413452634
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TRPC4AP ZFYVE16 TRIM28 KNL1

1.05e-03181454694
GeneFamilyPhosphodiesterases

PDE3B PDE8B

1.61e-0324452681
GeneFamilyRing finger proteins

VPS11 TRIM28 MARCHF8 RNF207

4.78e-0327545458
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SELE SRPX

8.86e-03574521179
CoexpressionGSE29949_MICROGLIA_BRAIN_VS_CD8_NEG_DC_SPLEEN_UP

FLNA VPS11 CXCR3 CELSR2 ZNF165 TNFRSF1B

9.84e-06195666M8421
CoexpressionCUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.17e-05117665M39300
CoexpressionDESCARTES_FETAL_THYMUS_STROMAL_CELLS

FBLN1 FBN2 LRP1 ZDBF2 SRPX

2.51e-05137665M40313
CoexpressionLIU_PROSTATE_CANCER_DN

FLNA CERK CELSR2 EFEMP2 SSX2IP PRICKLE2 SRPX ITGB6

3.27e-05493668M19391
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRY1 FBLN1 EFEMP2 DNER LRP1 SRPX LY6E

1.56e-08194667e2db75f4de114631b8bda4e188f84446545538b7
ToppCellMild/Remission-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA CXCR3 ADGRE5 TNFRSF1B PRAG1 KNL1

3.20e-071846663d4864605c812862cf8926e02370eea3b8ccf32f
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B MANSC1 TMEM59 SCNN1G LY6E MUC5AC

4.49e-071956662a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCellBLOOD--(2)_B_cell-(2)_Memory_B_cells|(2)_B_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FLNA CXCR3 JCHAIN ADGRE5 TNFRSF1B LY6E

4.49e-07195666c25391931659881d4104b06cf07cb44efa635e39
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B PDE8B TMEM59 SCNN1G LY6E MUC5AC

4.49e-07195666576142b4e75457c0973051bccc4163bd624496af
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B PDE8B TMEM59 SCNN1G LY6E MUC5AC

4.49e-071956668f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRY1 FBLN1 DNER PRICKLE2 LRP1 SRPX

4.77e-07197666ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

SPRY1 FBN2 PDE8B LRP1 SRPX MMP17

5.21e-07200666bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B CELSR2 LRP5 TNFRSF1B LY6E

4.13e-061616653f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE PCSK1 IQSEC3 PDE8B SSX2IP

6.55e-061776657c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE PCSK1 IQSEC3 PDE8B SSX2IP

6.55e-06177665e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBLN1 EFEMP2 DNER LRP1 SRPX

7.50e-06182665e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN1 DNER PRICKLE2 LRP1 SRPX

7.50e-061826653dfa9187e9d2bab1d199079d29209c4648220ada
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBN2 EFEMP2 LRP1 SRPX

8.12e-06185665785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBN2 EFEMP2 LRP1 SRPX

8.12e-0618566597a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBN2 EFEMP2 LRP1 SRPX

8.34e-0618666594d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell15-Trachea-Epithelial-Secretory_progenitor|Trachea / Age, Tissue, Lineage and Cell class

FLNA BMPR1B EFEMP2 SCNN1G LRP5

8.55e-06187665be9fce9e74b2f170a2067f1b31d802912a578329
ToppCelldroplet-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 ADAM18 WNT1 EFEMP2 SRPX

9.24e-061906652abeb013bb83c578e67dcb985ba44ca63134950b
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 ADAM18 WNT1 EFEMP2 SRPX

9.48e-06191665d1205aab0937f2becfcd239610e9b78fb8a0c886
ToppCell(7)_Epithelial_cells-(7)_Epithelial-G_(Club-Clara_cells)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

BMPR1B PDE8B SCNN1G LY6E MUC5AC

9.72e-06192665c7c232545fad8ad327ab94bd0def8dc5daacd03d
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

BMPR1B PDE8B SCNN1G LY6E MUC5AC

9.97e-061936658ede7038a222c7e7ecaf7e86520823cf606cbee7
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

BMPR1B PDE8B SCNN1G LY6E MUC5AC

9.97e-061936650e7d7adfaa7191e34038fcda6677561ae13934eb
ToppCellBLOOD--(1)_T_cell-(1)_Activated_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FLNA CXCR3 TNFRSF1B NOTCH1 KNL1

1.02e-051946656a0cbb9d5c5c4effb02dff654c6c3b184026875c
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN1 DNER PRICKLE2 LRP1 SRPX

1.05e-05195665fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCell(2)_5-FU-(3)_LEPR+_perivascular_cells|(2)_5-FU / Stress and Cell class

SPRY1 FLNA DIPK1A EFEMP2 LRP1

1.07e-05196665cc0a172de71d9a1a882c9e78652dae70e007d012
ToppCellMild/Remission-B_intermediate-6|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA CXCR3 TNFRSF1B PRAG1 KNL1

1.10e-051976655370dda4a25e3a53d6fe2c887b7dabd7a58462b4
ToppCell(2)_5-FU-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

SPRY1 FLNA EFEMP2 LRP1 PRAG1

1.10e-05197665434ae0231972acba12d06279908cf407e70511ac
ToppCell5'-Adult-Appendix-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN1 DNER PRICKLE2 LRP1 SRPX

1.10e-05197665b11a5d909942a4299cbc0b27332b1a3f66f3bccd
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B PDE8B TMEM59 SCNN1G MUC5AC

1.10e-05197665ff19e4c45715752a04541ad6a0cdf5454c9daaa2
ToppCell11.5-Airway-Mesenchymal-Mesenchyme_SERPINF1-high|Airway / Age, Tissue, Lineage and Cell class

FBLN1 FBN2 DNER SRPX RNF207

1.10e-051976659a053a32ff9c3a85ef9a3382453acd619cc48546
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD8|GI_large-bowel / Manually curated celltypes from each tissue

SPRY1 FLNA CXCR3 ADGRE5 LY6E

1.13e-051986659a1488d7e80a15a278f044fac09a4bcafa6800fe
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

FLNA LRP1 TNFRSF1B LY6E MED13L

1.13e-0519866561ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B PDE8B TMEM59 SCNN1G MUC5AC

1.13e-05198665778fee7020c82d11ff3984a8e482a23e5d58165f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B PDE8B TMEM59 SCNN1G MUC5AC

1.13e-051986657896f9fb89822e8628fe0b90a489c4760c7b876c
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBN2 EFEMP2 LRP1 SRPX

1.13e-05198665524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell368C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 LRP1 SRPX LY6E

1.16e-051996658766796041965a1ba40ad7abdbc244bf1418c209
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN1 FBN2 EFEMP2 LRP1 SRPX

1.16e-0519966584545ced0c792bc77980a50d65e484eab648d47e
ToppCell368C-Fibroblasts-Fibroblast-D-|368C / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.16e-051996655a425e7d11c5911ff5855c27a7f058a7ed7abbb0
ToppCellwk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FBLN1 FBN2 EFEMP2 DNER SRPX

1.16e-051996658de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCell368C-Fibroblasts-Fibroblast-D|368C / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.16e-0519966566545eb7f65e450b742628fd431956e13330a0d3
ToppCellLPS_only-Mesenchymal_fibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.16e-05199665211c3a08f2d484ab7a3368006767289088f0d957
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts|LPS_only / Treatment groups by lineage, cell group, cell type

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.16e-051996651a0add79f4e34078b3475eb11c85a4234bda197c
ToppCell(5)_Fibroblast-D|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PCSK1 FBLN1 EFEMP2 LRP1 SRPX

1.16e-051996653f415620ad8b8d8c6871e1353e13f87b281fcc0e
ToppCell368C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 LRP1 SRPX LY6E

1.16e-05199665d39b40d84c72bdde756b805063317ecfad3784f8
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.18e-05200665ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCell390C-Fibroblasts-Fibroblast-H-|390C / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.18e-05200665ec7d6a08e34bcad5b3bbff56ebef96ae17e4cefd
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPRY1 FLNA FBN2 PDE8B MMP17

1.18e-05200665b5b5a32925f225610fe25a021a742d6397162863
ToppCell390C-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 LRP1 SRPX LY6E

1.18e-05200665019340e8b4b4944a49e14fdec7ce2954cbb8ba2e
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPRY1 FBN2 PDE8B SRPX MMP17

1.18e-05200665d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SPRY1 FBN2 PDE8B SRPX MMP17

1.18e-052006654e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCell390C-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 LRP1 SRPX LY6E

1.18e-05200665b6f21f5cc137eddf6ba90e81cae791b57d88d9d7
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte|Control_saline / Treatment groups by lineage, cell group, cell type

SPRY1 FLNA LRP1 SRPX MMP17

1.18e-05200665cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCell390C-Fibroblasts-Fibroblast-H|390C / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 FBLN1 EFEMP2 LRP1 SRPX

1.18e-05200665671e731977c58a0c44c36b56422085d93d999aad
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SELE SSX2IP SCNN1G RNF207

2.02e-05108664d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

BMPR1B FBN2 GPR156 CPB2

5.89e-05142664e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCell367C-Fibroblasts-Fibroblast-D-|367C / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 EFEMP2 LRP1 SRPX

8.07e-05154664dd3d34f065820e706515a13619f19a5b12734c8e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BMPR1B CNTNAP5 SCNN1G ZNF774

8.07e-05154664ce4b1e878cd88065fbfd2df18caf19703fec37d8
ToppCell367C-Fibroblasts-Fibroblast-D|367C / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 EFEMP2 LRP1 SRPX

8.07e-051546644bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCellfacs-Lung-EPCAM-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM18 FAM170A MAP10 ZNF3

8.27e-051556640e942609d3e060f1e589fee5997fc6299f3d18bc
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSIP2 SMPDL3B JCHAIN TMEM59

8.69e-0515766463502d0fd5972d71cdbe13bde167592c70acec32
ToppCellfacs-Marrow-B-cells-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B DNER LRP1 TNFRSF1B

8.69e-051576640966e347f8d32b13f8a3b3afba3f64637c69cdf9
ToppCellfacs-Marrow-B-cells-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B DNER LRP1 TNFRSF1B

8.69e-051576646ebfedd91d62c6d4aa8f046657a899a279f82ba2
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

FBLN1 CXCR3 JCHAIN LRP5

9.35e-0516066461f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

FBLN1 CXCR3 JCHAIN LRP5

9.35e-0516066434b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCellsevere-Myeloid-pDC|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CXCR3 JCHAIN LRP5 SRPX

9.58e-051616649e8e8ac11f7fb8c8697357c21034b613f191db2b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 PDE3B LRP1 SRPX

9.58e-05161664a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellBasal_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

BMPR1B MARCHF8 SSX2IP SCNN1G

1.03e-04164664b15a26130a1ea1b370b6e3be21f02a0d6aaf6b3c
ToppCelldroplet-Kidney-nan-24m-Myeloid-macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA SMPDL3B LRP1 TNFRSF1B

1.03e-04164664d0b6c29e61d15f4dbe4c1f6e5ed3e10f41f820ab
ToppCelldroplet-Kidney-nan-24m-Myeloid|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA SMPDL3B LRP1 TNFRSF1B

1.03e-04164664718cc64b7ef7d03d095be4b2b54c449154da568c
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA SMPDL3B LRP1 TNFRSF1B

1.05e-0416566411227bff52eed30b80937fdb1968d0b8e6d30365
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA SMPDL3B LRP1 TNFRSF1B

1.05e-04165664036f9749048e5e50769cc3210339bf4da469215d
ToppCelldroplet-Spleen-nan-18m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 SMPDL3B LRP1 TNFRSF1B

1.08e-04166664e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCell10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-NK_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

IQSEC3 CNTNAP5 ZDBF2 MAP10

1.08e-04166664b041010038a570ad929812f35514cb54e4f68f66
ToppCell3'-Adult-LargeIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELE PCSK1 CXCR3 JCHAIN

1.08e-04166664b64ab3d13b76bba3c305ebbfc96f983cd6ca30c9
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B CNTNAP5 PDE8B SCNN1G

1.08e-041666649e98e6070055bfc780becee52d77830e06b6d854
ToppCelldroplet-Spleen-nan-18m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 SMPDL3B LRP1 TNFRSF1B

1.08e-041666643ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCelldroplet-Spleen-nan-18m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 SMPDL3B LRP1 TNFRSF1B

1.08e-04166664f751cbd01d4978ded7755874ab60504f6291afd7
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B PDE8B TMEM59 MUC5AC

1.10e-0416766431633899aae852873a4887e72c621474b0a51a33
ToppCelldroplet-Kidney-nan-24m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA SMPDL3B LRP1 TNFRSF1B

1.10e-041676642ee1660be117e20f24557522345572d11cbee813
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B DIPK1A LRP1 TNFRSF1B

1.13e-04168664f45dbcd7753117a3e41e1412bce2100d52fa7fd0
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA SMPDL3B LRP1 TNFRSF1B

1.13e-04168664c0aef5947b1d7e2c81a7481c509feda1687fcd7f
ToppCellcontrol-Myeloid-pDC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

JCHAIN SSX2IP LRP5 MAP10

1.13e-04168664affc39c7568b7df4b36af6f5b0e3702a18b6268c
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B LRP1 LRP5 TNFRSF1B

1.13e-04168664f3b7a7df54988de77dcc7066e2fc1feb9c280b13
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA SMPDL3B LRP1 TNFRSF1B

1.13e-04168664c861f80aa12caf54a94d93e38539ff41dc5227a6
ToppCelldroplet-Spleen-nan-3m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B DNER LRP1 TNFRSF1B

1.15e-0416966491cfff1ad559cc327c6bb71c98aa29f0b3642568
ToppCelldroplet-Spleen-nan-3m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B DNER LRP1 TNFRSF1B

1.15e-041696648e5e513090e86ca29fb61dfd388014774c506914
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA SMPDL3B LRP1 TNFRSF1B

1.15e-04169664b059304543876f514d5c7214f1f0a2da00f10a67
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA SMPDL3B LRP1 TNFRSF1B

1.15e-04169664945f737984c4de70a4e9c214053b005358053dd5
ToppCelldroplet-Spleen-nan-3m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B DNER LRP1 TNFRSF1B

1.15e-04169664972618e684321060c7af2429f853a6d639e8aae8
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CXCR3 ZNF154 ZNF165 JCHAIN

1.18e-04170664db0ec8b7ecbb4db108fc35c564df4b740f65cc8f
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CXCR3 ZNF154 ZNF165 JCHAIN

1.18e-0417066488f6804e973863245ca1c7e5e6656d4a8b824da9
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B LRP1 LRP5 TNFRSF1B

1.18e-041706647cb7ad9ab064b6ea452545d145e5b1d4090cd4c1
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK1 DNER CPB2 ZDBF2

1.18e-04170664941d637cf76918ee4b0a1833abd1a42593cb8b1a
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPDL3B LRP1 LRP5 TNFRSF1B

1.18e-04170664db7cee7e518debb2cbe9eeae05d47e14b69cb8e3
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CXCR3 ZNF154 ZNF165 JCHAIN

1.18e-04170664dad3aaf7d9f7bafdbddee51610f03f2359e587ae
ToppCellfacs-BAT-Fat-18m-Myeloid-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA SMPDL3B LRP1 TNFRSF1B

1.24e-0417266436fe66a8c0aecee7a19269be23210c0ed7abb155
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK1 CXCR3 SSX2IP CPB2

1.26e-0417366415a77f6aac968b7a1afea4f60aedbb95b9d0f765
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR1B PDE8B TMEM59 MUC5AC

1.26e-041736643aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

BMPR1B PDE8B SCNN1G MUC5AC

1.26e-04173664464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCellwk_08-11-Mesenchymal-Fibroblast-Airway_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SSX2IP LRP1 GPR156 SRPX

1.26e-04173664b23b408acc29a667cce104429afef1a6cf2720a5
ComputationalPlacenta genes.

FLNA VPS11 FBLN1 TRPC4AP FBN2 SMPDL3B LRP1 ADGRE5 SRPX TNFRSF1B

1.06e-054634310MODULE_38
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FLNA FBN2 EFEMP2 NOTCH1

5.11e-0653634C4707243
Diseaseosteoporosis (is_implicated_in)

WNT1 LRP5 TNFRSF1B

4.00e-0531633DOID:11476 (is_implicated_in)
Diseaseendometrial cancer (is_marker_for)

EFEMP2 TNFRSF1B NOTCH1

5.78e-0535633DOID:1380 (is_marker_for)
Diseaseretinal vasculature measurement

USP2 ZNF804B DNER MED13L PRAG1 KNL1 ZNF3

1.15e-04517637EFO_0010554
Diseaseurate measurement, bone density

FSIP2 FBLN1 PDE3B CNTNAP5 MANSC1 DNER ITGB6

3.46e-04619637EFO_0003923, EFO_0004531
Diseaseextrinsic allergic alveolitis (is_marker_for)

CXCR3 TNFRSF1B

4.02e-0414632DOID:841 (is_marker_for)
DiseaseVan Buchem disease

FLNA LRP5

5.98e-0417632C0432272
DiseaseLung diseases

EFEMP2 SCNN1G ADGRE5

6.30e-0478633C0024115
Diseaseosteochondrodysplasia (is_implicated_in)

FLNA BMPR1B

7.49e-0419632DOID:2256 (is_implicated_in)
DiseaseHIV-1 infection, Susceptibility to viral and mycobacterial infections

ADAM18 GPR156

9.18e-0421632EFO_0000180, Orphanet_391311
Diseasee-selectin measurement

SELE CELSR2

1.01e-0322632EFO_0004575
Diseaseeosinophil count

FLNA PDE8B DIPK1A EFEMP2 TNFRSF1B MMP17 GDI1 MUC5AC ITGB6 NOTCH1

1.15e-0314886310EFO_0004842
Diseaseobesity (implicated_via_orthology)

PCSK1 WNT1 MED13L NOTCH1

1.17e-03215634DOID:9970 (implicated_via_orthology)
Diseasechronic obstructive pulmonary disease (is_marker_for)

CXCR3 TNFRSF1B MUC5AC

1.19e-0397633DOID:3083 (is_marker_for)
DiseaseIgA glomerulonephritis (is_implicated_in)

SELE TNFRSF1B

1.88e-0330632DOID:2986 (is_implicated_in)
DiseaseL-Selectin measurement

SELE GPR156

2.00e-0331632EFO_0008202

Protein segments in the cluster

PeptideGeneStartEntry
SYDYGENESDSCCTS

CXCR3

26

P49682
SQEGCYSGCSLSYTN

SSX2IP

591

Q9Y2D8
PECDFTEYCNGTSSN

ADAM18

456

Q9Y3Q7
TEYCNGTSSNCVPDT

ADAM18

461

Q9Y3Q7
DSSTVCFNTVGSYSC

ADGRE5

221

P48960
SYCSNDWDSYSCSCD

CELSR2

1806

Q9HCU4
DSVNNICSTDGYCFT

BMPR1B

41

O00238
YSTISEFCTGETCQT

MOB2

71

Q70IA6
NGANCTDCVDSYTCT

NOTCH1

956

P46531
SPCYSEDFCTSEDTS

MAP10

706

Q9P2G4
DSSNEDQYRCTCGFS

MED13L

1151

Q71F56
FDECSVYGTCSQLCT

LRP1

151

Q07954
NSVSYSAGVCDEACS

SMPDL3B

396

Q92485
TPCSTDVCDSDYSAS

LRP5

1541

O75197
SAKDSYSDEQFSCCS

FSIP2

1966

Q5CZC0
GEYCNCTTSTDSCVS

ITGB6

571

P18564
YVSTSESDGTDCCSG

PDE3B

586

Q13370
SCSNPDESYGCLSSN

PDE3B

791

Q13370
HCCSSAEAETQTCYT

PDE8B

96

O95263
YGICHSDTNSSCCTE

MARCHF8

266

Q5T0T0
ALCYTAACTNTSCSG

SELE

136

P16581
YTSTQEDCINSCCST

MANSC1

56

Q9H8J5
CSCGSLSSQYDYSED

LCA5L

56

O95447
SHATAVCGSSDNYSC

KNL1

1316

Q8NG31
ASSSVAYSTQTCFCN

MUC5AC

4771

P98088
QALSCYTSSSSDSCG

IQSEC3

1116

Q9UPP2
SSVVCVCNATYCDSF

GBA

51

P04062
EYDWCSTCSSSSESD

PRICKLE2

771

Q7Z3G6
SSCGTGYELTEDNSC

FBLN1

246

P23142
EEGASSSSCSETYCG

CPB2

266

Q96IY4
FSSATTSICYCASCE

COLCA2

96

A8K830
SCTDNQDGTCSVSYL

FLNA

1911

P21333
TDCVCYSTVGTSDAE

CERK

241

Q8TCT0
CSDQDNYCVTVSASA

LY6E

41

Q16553
PYCEICFQSSSDSSD

GPR156

761

Q8NFN8
SEDSYSCCQQSSCQP

KRTAP10-9

156

P60411
ACQSGYTSSCTTPCY

KRTAP10-10

61

P60014
SCSYDATTHFETTCN

GDI1

401

P31150
SNICDEDSATETCYT

JCHAIN

111

P01591
TGECSNTVGSYFCVC

FBN2

331

P35556
QCTNSEGSYECSCSE

FBN2

1256

P35556
CSDIDECSYSSYLCQ

EFEMP2

241

O95967
SSSSSSDGYLCICNE

DNER

111

Q8NFT8
EATFSCTCEEQYVGT

DNER

331

Q8NFT8
DCVYGTDCRTSCDQS

DIPK1A

336

Q5T7M9
LCSNDTSDCATYTFS

SCNN1G

206

P51170
CSQSWTTFYCNCSDT

CNTNAP5

561

Q8WYK1
NCSDTSYTGATCHNS

CNTNAP5

571

Q8WYK1
GGCYRFDSSSCSSED

DRICH1

136

Q6PGQ1
SEQDVETTYFCNTCG

RNF207

106

Q6ZRF8
DSTCLENSSCISFSY

TRPC4AP

746

Q8TEL6
QSRSEDGYEVCSCTS

MMP17

551

Q9ULZ9
SSDGDNYGATCEFSC

SRPX

276

P78539
CESACTEAYSQSDEQ

TMEM59

96

Q9BXS4
SSCSQGSLAQYSCAD

WDR90

801

Q96KV7
IYCDSNSQISCTGSS

ZNF804B

826

A4D1E1
CFESYSESDADCPTC

VPS11

846

Q9H270
YECSDCGKTFSCSSA

ZNF3

256

P17036
YCTECGNSFTSSSEF

ZNF19

246

P17023
YRCNDCGESFSQSSD

ZNF774

291

Q6NX45
QGVGEVTSTSEYCSC

FAM170A

46

A1A519
VDNYGSSCSETSFDC

ZDBF2

571

Q9HCK1
DEGDSYSDNPCSCSQ

SPRY1

236

O43609
SQSEESYFCGISACT

SUCO

1171

Q9UBS9
CDSGDAIYYCATCSE

PRAG1

1001

Q86YV5
RSCSEGSIESCTCDY

WNT1

141

P04628
YECSECGRAFSQSSN

ZNF165

456

P49910
SDTVCDSCEDSTYTQ

TNFRSF1B

71

P20333
YECSECGKSFSQNSS

ZNF154

301

Q13106
SSLTCTDCGYCSTVF

USP2

421

O75604
ECVNSCASSETSYGT

ZFYVE16

61

Q7Z3T8
QCCTSCEDNAPATSY

TRIM28

151

Q13263
NCDCDGYTDSIYTIS

PCSK1

316

P29120