Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC25A12 SLC25A13 SLC22A15 SLC19A3	3.22e-06	33	62	4	GO:0072349
GeneOntologyMolecularFunction	aspartate:glutamate, proton antiporter activity	SLC25A12 SLC25A13	9.49e-06	2	62	2	GO:0000515
GeneOntologyMolecularFunction	3-sulfino-L-alanine: proton, glutamate antiporter activity	SLC25A12 SLC25A13	9.49e-06	2	62	2	GO:0000514
GeneOntologyMolecularFunction	transporter activity	NIPAL4 SLC16A13 ABCB7 SLC25A12 SLC12A1 SLC25A13 SLC22A15 SLC19A3 COX15 TOMM20 SLC16A11 TIMM29 KCNG3 AQP2	3.16e-05	1289	62	14	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	NIPAL4 SLC16A13 ABCB7 SLC25A12 SLC12A1 SLC25A13 SLC22A15 SLC19A3 COX15 TOMM20 SLC16A11 KCNG3 AQP2	5.53e-05	1180	62	13	GO:0022857
GeneOntologyMolecularFunction	amino acid:monoatomic cation antiporter activity	SLC25A12 SLC25A13	9.43e-05	5	62	2	GO:0140848
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC16A13 ABCB7 SLC25A12 SLC12A1 SLC25A13 COX15 TOMM20 SLC16A11	1.09e-04	477	62	8	GO:0022804
GeneOntologyMolecularFunction	ethanol binding	ADH1A ADH1B	1.41e-04	6	62	2	GO:0035276
GeneOntologyMolecularFunction	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	PFAS CPS1	4.20e-04	10	62	2	GO:0016884
GeneOntologyMolecularFunction	L-aspartate transmembrane transporter activity	SLC25A12 SLC25A13	4.20e-04	10	62	2	GO:0015183
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC16A13 SLC25A12 SLC25A13 SLC19A3 SLC16A11	4.57e-04	207	62	5	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC16A13 SLC25A12 SLC25A13 SLC19A3 SLC16A11	4.67e-04	208	62	5	GO:0005342
GeneOntologyMolecularFunction	sulfur amino acid transmembrane transporter activity	SLC25A12 SLC25A13	5.12e-04	11	62	2	GO:0000099
GeneOntologyMolecularFunction	ligase activity, forming carbon-nitrogen bonds	PFAS CPS1 PPCS	5.98e-04	53	62	3	GO:0016879
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	SLC25A12 SLC25A13 SLC19A3	9.02e-04	61	62	3	GO:1901682
GeneOntologyMolecularFunction	C4-dicarboxylate transmembrane transporter activity	SLC25A12 SLC25A13	9.70e-04	15	62	2	GO:0015556
GeneOntologyMolecularFunction	L-glutamate transmembrane transporter activity	SLC25A12 SLC25A13	9.70e-04	15	62	2	GO:0005313
GeneOntologyMolecularFunction	NAD binding	ALDH5A1 ADH1A ADH1B	1.52e-03	73	62	3	GO:0051287
GeneOntologyMolecularFunction	acidic amino acid transmembrane transporter activity	SLC25A12 SLC25A13	1.74e-03	20	62	2	GO:0015172
GeneOntologyMolecularFunction	integrin binding	ICAM5 ITGA3 ITGA4 ITGA5	2.14e-03	175	62	4	GO:0005178
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC16A13 SLC25A12 SLC25A13 SLC19A3 SLC16A11	2.15e-03	293	62	5	GO:0008514
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC16A13 SLC25A12 SLC12A1 SLC25A13 SLC16A11	2.25e-03	296	62	5	GO:0015291
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	ADH1A ADH1B	2.51e-03	24	62	2	GO:0004745
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	ADH1A ADH1B	2.94e-03	26	62	2	GO:0004022
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	ADH1A ADH1B	3.90e-03	30	62	2	GO:0018455
GeneOntologyMolecularFunction	dicarboxylic acid transmembrane transporter activity	SLC25A12 SLC25A13	4.16e-03	31	62	2	GO:0005310
GeneOntologyMolecularFunction	fibronectin binding	ITGA3 ITGA4	6.21e-03	38	62	2	GO:0001968
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	ADRA2C TAAR9	7.20e-03	41	62	2	GO:0008227
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC25A12 SLC25A13	7.20e-03	41	62	2	GO:0015175
GeneOntologyMolecularFunction	protein transporter activity	TOMM20 TIMM29	7.54e-03	42	62	2	GO:0140318
GeneOntologyBiologicalProcess	acetaldehyde biosynthetic process	ADH1A ADH1B	2.66e-05	3	62	2	GO:0046186
GeneOntologyBiologicalProcess	L-amino acid metabolic process	SLC25A12 SLC25A13 PFAS CPS1 ALDH5A1 KYAT1	3.76e-05	208	62	6	GO:0170033
GeneOntologyBiologicalProcess	acetaldehyde metabolic process	ADH1A ADH1B	8.84e-05	5	62	2	GO:0006117
GeneOntologyBiologicalProcess	malate-aspartate shuttle	SLC25A12 SLC25A13	8.84e-05	5	62	2	GO:0043490
GeneOntologyBiologicalProcess	glutamine family amino acid metabolic process	SLC25A12 PFAS CPS1 ALDH5A1	9.86e-05	80	62	4	GO:0009064
GeneOntologyBiologicalProcess	alpha-amino acid metabolic process	SLC25A12 SLC25A13 PFAS CPS1 ALDH5A1 KYAT1	1.06e-04	251	62	6	GO:1901605
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	SLC25A12 ASAH2 SLC25A13 PFAS CPS1 ALDH5A1 ADPGK ALOX12B KYAT1 ADH1A ADH1B	2.32e-04	1035	62	11	GO:0019752
GeneOntologyBiologicalProcess	proteinogenic amino acid metabolic process	SLC25A12 SLC25A13 PFAS CPS1 ALDH5A1	2.35e-04	185	62	5	GO:0170039
GeneOntologyBiologicalProcess	oxoacid metabolic process	SLC25A12 ASAH2 SLC25A13 PFAS CPS1 ALDH5A1 ADPGK ALOX12B KYAT1 ADH1A ADH1B	2.81e-04	1058	62	11	GO:0043436
GeneOntologyBiologicalProcess	mitochondrial transmembrane transport	ABCB7 SLC25A12 SLC25A13 TOMM20	2.92e-04	106	62	4	GO:1990542
GeneOntologyBiologicalProcess	organic acid metabolic process	SLC25A12 ASAH2 SLC25A13 PFAS CPS1 ALDH5A1 ADPGK ALOX12B KYAT1 ADH1A ADH1B	2.95e-04	1064	62	11	GO:0006082
GeneOntologyBiologicalProcess	mitochondrial transport	ABCB7 SLC25A12 SLC25A13 TOMM20 TIMM29	3.77e-04	205	62	5	GO:0006839
GeneOntologyBiologicalProcess	peptide modification	LANCL3 PGLYRP2	3.94e-04	10	62	2	GO:0031179
GeneOntologyBiologicalProcess	amino acid metabolic process	SLC25A12 SLC25A13 PFAS CPS1 ALDH5A1 KYAT1	4.79e-04	332	62	6	GO:0006520
GeneOntologyBiologicalProcess	L-aspartate transmembrane transport	SLC25A12 SLC25A13	4.80e-04	11	62	2	GO:0070778
GeneOntologyCellularComponent	integrin complex	ITGA3 ITGA4 ITGA5	1.22e-04	32	63	3	GO:0008305
Domain	Integrin_alpha_C_CS	ITGA3 ITGA4 ITGA5	1.89e-05	16	62	3	IPR018184
Domain	Integrin_alpha-2	ITGA3 ITGA4 ITGA5	2.74e-05	18	62	3	IPR013649
Domain	Integrin_alpha2	ITGA3 ITGA4 ITGA5	2.74e-05	18	62	3	PF08441
Domain	Integrin_alpha	ITGA3 ITGA4 ITGA5	2.74e-05	18	62	3	IPR000413
Domain	INTEGRIN_ALPHA	ITGA3 ITGA4 ITGA5	2.74e-05	18	62	3	PS00242
Domain	Int_alpha_beta-p	ITGA3 ITGA4 ITGA5	3.25e-05	19	62	3	IPR013519
Domain	Int_alpha	ITGA3 ITGA4 ITGA5	3.25e-05	19	62	3	SM00191
Domain	FG_GAP	ITGA3 ITGA4 ITGA5	5.13e-05	22	62	3	PS51470
Domain	FG-GAP	ITGA3 ITGA4 ITGA5	6.71e-05	24	62	3	PF01839
Domain	FG-GAP	ITGA3 ITGA4 ITGA5	6.71e-05	24	62	3	IPR013517
Domain	Integrin_dom	ITGA3 ITGA4 ITGA5	7.61e-05	25	62	3	IPR032695
Domain	MFS_dom	SLC16A13 MFSD6 SLC22A15 SLC19A3 SLC16A11	8.22e-05	134	62	5	IPR020846
Domain	GATASE	PFAS CPS1	1.61e-04	6	62	2	IPR017926
Domain	Ribokinase-like	RBKS ADPGK	1.61e-04	6	62	2	IPR029056
Domain	-	RBKS ADPGK	1.61e-04	6	62	2	3.40.1190.20
Domain	GATASE_TYPE_1	PFAS CPS1	1.61e-04	6	62	2	PS51273
Domain	ADH_Zn_CS	ADH1A ADH1B	3.00e-04	8	62	2	IPR002328
Domain	ADH_ZINC	ADH1A ADH1B	3.00e-04	8	62	2	PS00059
Domain	MFS	SLC16A13 MFSD6 SLC22A15 SLC16A11	4.56e-04	108	62	4	PS50850
Domain	-	PFAS CPS1	4.80e-04	10	62	2	3.40.50.880
Domain	Integrin_alpha	ITGA4 ITGA5	5.85e-04	11	62	2	PF00357
Domain	Class_I_gatase-like	PFAS CPS1	7.00e-04	12	62	2	IPR029062
Domain	SOLCAR	SLC25A12 SLC25A13 SLC25A34	7.25e-04	53	62	3	PS50920
Domain	-	SLC25A12 SLC25A13 SLC25A34	7.25e-04	53	62	3	1.50.40.10
Domain	Mitochondrial_sb/sol_carrier	SLC25A12 SLC25A13 SLC25A34	7.25e-04	53	62	3	IPR018108
Domain	Mito_carr	SLC25A12 SLC25A13 SLC25A34	7.25e-04	53	62	3	PF00153
Domain	Mt_carrier_dom	SLC25A12 SLC25A13 SLC25A34	7.25e-04	53	62	3	IPR023395
Domain	ADH_N	ADH1A ADH1B	1.26e-03	16	62	2	PF08240
Domain	PKS_ER	ADH1A ADH1B	1.26e-03	16	62	2	SM00829
Domain	PKS_ER	ADH1A ADH1B	1.26e-03	16	62	2	IPR020843
Domain	ADH_N	ADH1A ADH1B	1.26e-03	16	62	2	IPR013154
Domain	-	ADH1A ADH1B	1.60e-03	18	62	2	3.90.180.10
Domain	ADH_zinc_N	ADH1A ADH1B	1.79e-03	19	62	2	PF00107
Domain	ADH_SF_Zn-type	ADH1A ADH1B	1.79e-03	19	62	2	IPR002085
Domain	ADH_C	ADH1A ADH1B	1.79e-03	19	62	2	IPR013149
Domain	MFS_1	SLC16A13 MFSD6 SLC16A11	2.14e-03	77	62	3	PF07690
Domain	MFS	SLC16A13 MFSD6 SLC16A11	2.14e-03	77	62	3	IPR011701
Domain	GroES-like	ADH1A ADH1B	2.85e-03	24	62	2	IPR011032
Domain	Aden_trnslctor	SLC25A12 SLC25A13	3.88e-03	28	62	2	IPR002113
Domain	Mit_carrier	SLC25A12 SLC25A13	5.04e-03	32	62	2	IPR002067
Pathway	PID_ARF6_TRAFFICKING_PATHWAY	PLD2 ITGA3 ITGA4 ITGA5	2.64e-05	49	50	4	M67
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY	ITGA3 ITGA4 ITGA5	7.07e-05	23	50	3	M47537
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY	ITGA3 ITGA4 ITGA5	7.07e-05	23	50	3	M47720
Pathway	WP_UREA_CYCLE_AND_ASSOCIATED_PATHWAYS	SLC25A12 SLC25A13 CPS1	8.06e-05	24	50	3	M39850
Pathway	PID_INTEGRIN_CS_PATHWAY	ITGA3 ITGA4 ITGA5	1.03e-04	26	50	3	M47
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY	ITGA3 ITGA4 ITGA5	1.03e-04	26	50	3	M47719
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	ITGA3 ITGA4 ITGA5	1.29e-04	28	50	3	M47655
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	ICAM5 ITGA3 ITGA4 ITGA5	1.49e-04	76	50	4	MM14867
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY	ITGA3 ITGA4 ITGA5	1.59e-04	30	50	3	M47724
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	ITGA3 ITGA4 ITGA5	1.59e-04	30	50	3	M47718
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	ICAM5 ITGA3 ITGA4 ITGA5	2.29e-04	85	50	4	M16441
Pathway	REACTOME_ABACAVIR_ADME	ADH1A ADH1B	3.41e-04	8	50	2	MM14869
Pathway	REACTOME_MALATE_ASPARTATE_SHUTTLE	SLC25A12 SLC25A13	4.37e-04	9	50	2	M48269
Pathway	WP_UREA_CYCLE_AND_RELATED_DISEASES	SLC25A13 CPS1	4.37e-04	9	50	2	M39833
Pathway	REACTOME_MALATE_ASPARTATE_SHUTTLE	SLC25A12 SLC25A13	4.37e-04	9	50	2	MM17242
Pathway	WP_FATTY_ACID_OMEGAOXIDATION	ADH1A ADH1B	5.45e-04	10	50	2	MM15833
Pathway	REACTOME_ASPARTATE_AND_ASPARAGINE_METABOLISM	SLC25A12 SLC25A13	6.64e-04	11	50	2	M27836
Pathway	REACTOME_ETHANOL_OXIDATION	ADH1A ADH1B	6.64e-04	11	50	2	MM15405
Pathway	REACTOME_ETHANOL_OXIDATION	ADH1A ADH1B	7.95e-04	12	50	2	M14663
Pathway	REACTOME_ASPARTATE_AND_ASPARAGINE_METABOLISM	SLC25A12 SLC25A13	7.95e-04	12	50	2	MM15556
Pathway	WP_FATTY_ACID_OMEGAOXIDATION	ADH1A ADH1B	1.26e-03	15	50	2	M39717
Pathway	REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT	SLC25A12 SLC25A13 TOMM20	1.57e-03	65	50	3	M590
Pathway	PID_INTEGRIN1_PATHWAY	ITGA3 ITGA4 ITGA5	1.64e-03	66	50	3	M18
Pubmed	The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.	ITGA3 ITGA4 ITGA5	2.37e-08	4	64	3	3033641
Pubmed	The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.	ITGA3 ITGA4 ITGA5	1.18e-07	6	64	3	3546305
Pubmed	Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte.	ITGA3 ITGA4 ITGA5	3.31e-07	8	64	3	7691492
Pubmed	Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.	ITGA3 ITGA4 ITGA5	4.95e-07	9	64	3	1693624
Pubmed	Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels.	ITGA3 ITGA4 ITGA5	1.68e-06	13	64	3	20563599
Pubmed	Integrin requirement for hippocampal synaptic plasticity and spatial memory.	ITGA3 ITGA4 ITGA5	3.27e-06	16	64	3	12904471
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	ABCB7 SLC25A12 ASAH2 SLC25A13 CPS1 ALDH5A1 MUTYH	3.27e-06	343	64	7	28130547
Pubmed	Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.	SLC25A12 SLC25A13	3.33e-06	2	64	2	25410934
Pubmed	TMT-Based Quantitative Proteomic Analysis Identification of Integrin Alpha 3 and Integrin Alpha 5 as Novel Biomarkers in Pathogenesis of Acute Aortic Dissection.	ITGA3 ITGA5	3.33e-06	2	64	2	32851057
Pubmed	Characterization of integrin expression in islets isolated from hamster, canine, porcine, and human pancreas.	ITGA3 ITGA5	3.33e-06	2	64	2	10082751
Pubmed	Aqp2-expressing cells give rise to renal intercalated cells.	DOT1L AQP2	3.33e-06	2	64	2	23308014
Pubmed	The alpha4beta1 and alpha5beta1 integrins mediate engraftment of granulocyte-colony-stimulating factor-mobilized human hematopoietic progenitor cells.	ITGA4 ITGA5	3.33e-06	2	64	2	15987366
Pubmed	Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation.	ITGA4 ITGA5	3.33e-06	2	64	2	22644786
Pubmed	Exogenous aralar/slc25a12 can replace citrin/slc25a13 as malate aspartate shuttle component in liver.	SLC25A12 SLC25A13	3.33e-06	2	64	2	36967723
Pubmed	AGC1/2, the mitochondrial aspartate-glutamate carriers.	SLC25A12 SLC25A13	3.33e-06	2	64	2	27132995
Pubmed	Increased binding and defective migration across fibronectin of cycling hematopoietic progenitor cells.	ITGA4 ITGA5	3.33e-06	2	64	2	11877275
Pubmed	Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.	SLC25A12 SLC25A13	3.33e-06	2	64	2	12084073
Pubmed	Distribution of alpha3, alpha5 and alpha(v) integrin subunits in mature and immature human oocytes.	ITGA3 ITGA5	3.33e-06	2	64	2	9809676
Pubmed	The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.	SLC25A12 SLC25A13	3.33e-06	2	64	2	10369257
Pubmed	Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle.	SLC25A12 SLC25A13	3.33e-06	2	64	2	17213189
Pubmed	Abnormal urinary excretion of NKCC2 and AQP2 in response to hypertonic saline in chronic kidney disease: an intervention study in patients with chronic kidney disease and healthy controls.	SLC12A1 AQP2	3.33e-06	2	64	2	24970686
Pubmed	Down regulation of ITGA4 and ITGA5 genes after formation of 3D spherules by human Wharton's jelly stem cells (hWJSCs).	ITGA4 ITGA5	3.33e-06	2	64	2	29411210
Pubmed	IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses.	ITGA3 ITGA4 ITGA5	6.63e-06	20	64	3	22687584
Pubmed	Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains.	ITGA3 ITGA5	9.99e-06	3	64	2	14596610
Pubmed	Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family.	ICAM5 APLP2	9.99e-06	3	64	2	9244438
Pubmed	Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family.	ADH1A ADH1B	9.99e-06	3	64	2	10424757
Pubmed	Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase.	ADH1A ADH1B	9.99e-06	3	64	2	11960985
Pubmed	Tissue-specific genetic variation in the level of mouse alcohol dehydrogenase is controlled transcriptionally in kidney and posttranscriptionally in liver.	ADH1A ADH1B	9.99e-06	3	64	2	2474823
Pubmed	Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization.	ADH1A ADH1B	9.99e-06	3	64	2	2737681
Pubmed	Regulation of human class I alcohol dehydrogenases by bile acids.	ADH1A ADH1B	9.99e-06	3	64	2	23772048
Pubmed	A negative regulatory element upstream from the mouse Adh-1 gene can down-regulate a heterologous promoter.	ADH1A ADH1B	9.99e-06	3	64	2	8163197
Pubmed	ALDH expression characterizes G1-phase proliferating beta cells during pregnancy.	ADH1A ADH1B	9.99e-06	3	64	2	24787690
Pubmed	Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer: Models for Global and Disease-Free Survival.	ITGA3 ITGA5	9.99e-06	3	64	2	26674523
Pubmed	An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene.	SLC25A12 ITGA4	9.99e-06	3	64	2	18348195
Pubmed	The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.	ADH1A ADH1B	9.99e-06	3	64	2	2347582
Pubmed	VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells through induction of VLA-4 expression.	ITGA4 ITGA5	9.99e-06	3	64	2	19460753
Pubmed	Androgen induction of alcohol dehydrogenase in mouse kidney. Studies with a cDNA probe confirmed by nucleotide sequence analysis.	ADH1A ADH1B	9.99e-06	3	64	2	3011597
Pubmed	Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation.	ITGA4 ITGA5	9.99e-06	3	64	2	17472576
Pubmed	Alcohol dehydrogenase isozymes in the mouse: genetic regulation, allelic variation among inbred strains and sex differences of liver and kidney A2 isozyme activity.	ADH1A ADH1B	9.99e-06	3	64	2	6756216
Pubmed	Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms.	ADH1A ADH1B	9.99e-06	3	64	2	17326332
Pubmed	The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome.	ADH1A ADH1B	9.99e-06	3	64	2	7748347
Pubmed	Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis inhibitor against septic acute kidney injury.	ADH1A ADH1B	9.99e-06	3	64	2	37806378
Pubmed	Structure and function of a long alternating purine-pyrimidine sequence in the mouse alcohol dehydrogenase Adh-1 gene.	ADH1A ADH1B	9.99e-06	3	64	2	7840644
Pubmed	Requirement of alpha(4)beta(1) and alpha(5)beta(1) integrin expression in bone-marrow-derived progenitor cells in preventing endotoxin-induced lung vascular injury and edema in mice.	ITGA4 ITGA5	9.99e-06	3	64	2	19839056
Pubmed	Genetics of human alcohol and aldehyde dehydrogenases.	ADH1A ADH1B	9.99e-06	3	64	2	3006456
Pubmed	Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice.	ADH1A ADH1B	9.99e-06	3	64	2	9145544
Pubmed	Structure of the mouse Adh-1 gene and identification of a deletion in a long alternating purine-pyrimidine sequence in the first intron of strains expressing low alcohol dehydrogenase activity.	ADH1A ADH1B	9.99e-06	3	64	2	3428612
Pubmed	Genetic and developmental regulation of mouse liver alcohol dehydrogenase.	ADH1A ADH1B	9.99e-06	3	64	2	6816803
Pubmed	Functional differences between integrin alpha4 and integrins alpha5/alphav in modulating the motility of human oral squamous carcinoma cells in response to the V region and heparin-binding domain of fibronectin.	ITGA4 ITGA5	9.99e-06	3	64	2	15051489
Pubmed	Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.	DOT1L AQP2	9.99e-06	3	64	2	23326416
Pubmed	Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.	ADH1A ADH1B	9.99e-06	3	64	2	15670660
Pubmed	Identification of countercurrent tubule-vessel arrangements in the early development of mouse kidney based on immunohistochemistry and computer-assisted 3D visualization.	SLC12A1 AQP2	9.99e-06	3	64	2	39137214
Pubmed	In vivo roles of integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for alpha 5, alpha v, and alpha 4 integrins.	ITGA4 ITGA5	9.99e-06	3	64	2	11035110
Pubmed	Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice.	ITGA4 ITGA5	9.99e-06	3	64	2	19144663
Pubmed	Deletion of the prorenin receptor in the ureteric bud in mice inhibits Dot1/H3K79 pathway.	DOT1L AQP2	9.99e-06	3	64	2	38287105
Pubmed	Ten kilobases of 5'-flanking region confers proper regulation of the mouse alcohol dehydrogenase-1 (Adh-1) gene in kidney and adrenal of transgenic mice.	ADH1A ADH1B	9.99e-06	3	64	2	8973327
Pubmed	The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.	ADH1A ADH1B	9.99e-06	3	64	2	15554233
Pubmed	ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.	ADH1A ADH1B	9.99e-06	3	64	2	35354963
Pubmed	Purification and characterization of mouse alcohol dehydrogenase from two inbred strains that differ in total liver enzyme activity.	ADH1A ADH1B	9.99e-06	3	64	2	6370228
Pubmed	Stage and tissue-specific expression of the alcohol dehydrogenase 1 (Adh-1) gene during mouse development.	ADH1A ADH1B	9.99e-06	3	64	2	8018987
Pubmed	NAGS, CPS1, and SLC25A13 (Citrin) at the Crossroads of Arginine and Pyrimidines Metabolism in Tumor Cells.	SLC25A13 CPS1	9.99e-06	3	64	2	37047726
Pubmed	Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.	ADH1A ADH1B	9.99e-06	3	64	2	33586683
Pubmed	Expression and Prognostic Analyses of ITGA3, ITGA5, and ITGA6 in Head and Neck Squamous Cell Carcinoma.	ITGA3 ITGA5	9.99e-06	3	64	2	33099569
Pubmed	Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase.	ADH1A ADH1B	9.99e-06	3	64	2	3157987
Pubmed	Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box.	ADH1A ADH1B	9.99e-06	3	64	2	2169444
Pubmed	A novel negative element in the promoter of the mouse alcohol dehydrogenase gene Adh-1.	ADH1A ADH1B	9.99e-06	3	64	2	8486690
Pubmed	Stage-specific functional roles of integrins in murine erythropoiesis.	ITGA4 ITGA5	9.99e-06	3	64	2	24463276
Pubmed	Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.	ADH1A ADH1B	9.99e-06	3	64	2	2935875
Pubmed	Individual susceptibility and alcohol effects:biochemical and genetic aspects.	ADH1A ADH1B	9.99e-06	3	64	2	16801720
Pubmed	Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.	ITGA3 ITGA4 ITGA5	1.03e-05	23	64	3	23152823
Pubmed	Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.	SLC12A1 DOT1L AQP2	1.03e-05	23	64	3	33315499
Pubmed	Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.	ABCB7 SLC25A12 COX15 TOMM20 TIMM29 CPS1 MUTYH	1.10e-05	413	64	7	27499296
Pubmed	HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis.	SLC12A1 PKHD1 AQP2	1.33e-05	25	64	3	29158444
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA3 ITGA4 ITGA5	1.68e-05	27	64	3	31541017
Pubmed	Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia.	SLC25A12 SLC25A13	2.00e-05	4	64	2	14701727
Pubmed	Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes.	ADH1A ADH1B	2.00e-05	4	64	2	11893554
Pubmed	Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation.	ITGA3 ITGA5	2.00e-05	4	64	2	20052668
Pubmed	Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.	ITGA3 ITGA4	2.00e-05	4	64	2	10852818
Pubmed	Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.	ADH1A ADH1B	2.00e-05	4	64	2	29663519
Pubmed	Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid.	ADH1A ADH1B	2.00e-05	4	64	2	12851412
Pubmed	Reappraising the role of α5 integrin and the microenvironmental support in stress erythropoiesis.	ITGA4 ITGA5	2.00e-05	4	64	2	31887343
Pubmed	Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.	SLC25A12 SLC25A13	2.00e-05	4	64	2	11566871
Pubmed	ADH1 and ADH4 alcohol/retinol dehydrogenases in the developing adrenal blastema provide evidence for embryonic retinoid endocrine function.	ADH1A ADH1B	2.00e-05	4	64	2	9733106
Pubmed	Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury.	ADH1A ADH1B	2.00e-05	4	64	2	36224745
Pubmed	Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins.	ITGA4 ITGA5	2.00e-05	4	64	2	8930896
Pubmed	Retinoic acid and alcohol/retinol dehydrogenase in the mouse adrenal gland: a potential endocrine source of retinoic acid during development.	ADH1A ADH1B	2.00e-05	4	64	2	9202249
Pubmed	Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB.	ITGA3 ITGA5	2.00e-05	4	64	2	18464290
Pubmed	Genetic regulation of gene-specific mRNA by ethanol in vivo and its possible role in ethanol preference in a cross with RI lines in mice.	ADH1A ADH1B	2.00e-05	4	64	2	8813054
Pubmed	Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation.	ADH1A ADH1B	2.00e-05	4	64	2	12081471
Pubmed	An immunohistochemical study of beta1 integrin molecules (VLA-4, VLA-5, VLA-6) in all endometrial compartments of fertile and infertile women in Ahwaz-Iran.	ITGA4 ITGA5	2.00e-05	4	64	2	19579970
Pubmed	Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions.	ITGA3 ITGA5	2.00e-05	4	64	2	20382852
Pubmed	Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells.	ADH1A ADH1B	2.00e-05	4	64	2	19618839
Pubmed	Mouse mitochondrial aldehyde dehydrogenase isozymes: purification and molecular properties.	ADH1A ADH1B	2.00e-05	4	64	2	3996732
Pubmed	Ameloblastoma and adenomatoid odontogenic tumor: the role of alpha2beta1, alpha3beta1, and alpha5beta1 integrins in local invasiveness and architectural characteristics.	ITGA3 ITGA5	2.00e-05	4	64	2	17498594
Pubmed	Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex.	ADH1A ADH1B	2.00e-05	4	64	2	9241435
Pubmed	Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.	ADH1A ADH1B	2.00e-05	4	64	2	10880953
Pubmed	Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.	ADH1A ADH1B	2.00e-05	4	64	2	12631290
Pubmed	Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3.	ADH1A ADH1B	2.00e-05	4	64	2	2893758
Pubmed	The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.	ITGA4 ITGA5	2.00e-05	4	64	2	19454674
Pubmed	The expression of epidermal lipoxygenases and transglutaminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic pathway essential for skin barrier homeostasis.	NIPAL4 ALOX12B	2.00e-05	4	64	2	22622417
Cytoband	17p13.1	SLC16A13 PFAS SLC16A11 CHD3 PLD2 ALOX12B	1.85e-08	118	65	6	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	SLC16A13 PFAS SLC16A11 CHD3 PLD2 ALOX12B	9.97e-06	346	65	6	chr17p13
Cytoband	4q23	ADH1A ADH1B	3.69e-04	20	65	2	4q23
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ICAM5 PLPPR3 PGLYRP2 TIMM29 DOT1L GIPC3	9.30e-04	797	65	6	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr4q23	ADH1A ADH1B	1.27e-03	37	65	2	chr4q23
Cytoband	19p13.3	PLPPR3 DOT1L GIPC3	4.69e-03	237	65	3	19p13.3
GeneFamily	Solute carriers	SLC16A13 SLC25A12 SLC12A1 SLC25A13 SLC25A34 SLC22A15 SLC19A3 SLC16A11	5.14e-06	395	45	8	752
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA3 ITGA4 ITGA5	1.15e-05	18	45	3	1160
GeneFamily	Alcohol dehydrogenases	ADH1A ADH1B	1.68e-04	8	45	2	397
Coexpression	MOOTHA_HUMAN_MITODB_6_2002	IVNS1ABP ABCB7 SLC25A12 SLC25A13 COX15 TOMM20 CPS1 MUTYH	1.13e-05	432	65	8	M9433
ToppCell	HSPCs-LMPPs\|World / Lineage and Cell class	ZFP36L2 PLPPR3 SLC16A11 PGLYRP2 BEND4	7.14e-06	183	65	5	e401f06843528a75693ce455bbeff2a98b8c24e5
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP LANCL3 SLC25A12 SLC12A1 NDRG2	7.14e-06	183	65	5	03c7e69136d5a3b9c5b2c91733e9b1c791f45c49
Drug	N-methylformamide	ITGA3 ITGA4 ITGA5 PPCS KYAT1	1.08e-06	66	63	5	CID000031254
Drug	Chlormerodrin	SLC12A1 ALDH5A1	7.54e-06	2	63	2	DB00534
Disease	common bile duct disease (implicated_via_orthology)	SLC25A12 SLC25A13	4.34e-06	2	62	2	DOID:4137 (implicated_via_orthology)
Disease	citrullinemia (implicated_via_orthology)	SLC25A12 SLC25A13	1.30e-05	3	62	2	DOID:9273 (implicated_via_orthology)
Disease	intrahepatic cholestasis (implicated_via_orthology)	SLC25A12 SLC25A13	2.60e-05	4	62	2	DOID:1852 (implicated_via_orthology)
Disease	alcohol consumption measurement	MFSD6 PKHD1 RBKS BEND4 ITGA4 CPS1 KCNG3 SDK1 NUP160 ADH1A ADH1B	4.96e-05	1242	62	11	EFO_0007878
Disease	retinitis pigmentosa	ITGA4 TMEM271	6.48e-05	6	62	2	MONDO_0019200
Disease	Congenital ichthyosis of skin	NIPAL4 ALOX12B	2.36e-04	11	62	2	cv:C0020758
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	NIPAL4 ALOX12B	2.36e-04	11	62	2	C0079154
Disease	idiopathic scoliosis (implicated_via_orthology)	MBTPS1 KIF6	5.11e-04	16	62	2	DOID:0060250 (implicated_via_orthology)
Disease	Astrocytosis	ITGA4 ITGA5	5.79e-04	17	62	2	C3887640
Disease	Gliosis	ITGA4 ITGA5	5.79e-04	17	62	2	C0017639
Disease	alcohol use disorder measurement, alcohol dependence	PKHD1 ADH1B	1.16e-03	24	62	2	EFO_0009458, MONDO_0007079

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSAYAGFLALAVGCV	ADPGK	6	Q9BRR6
AAFYVAAQLLGAVAG	AQP2	86	P41181
GFSTGYGSAVNVAKV	ADH1A	176	P07327
GFSTGYGSAVNVAKV	ADH1B	176	P00325
YSAGAVAGLAAVVGF	ADRA2C	46	P18825
SFAAVVRYGPGAAAA	BEND4	131	Q6ZU67
VAALVGFLYDTGALG	ARMC5	391	Q96C12
ALGLTITDNGAGYAF	GIPC3	121	Q8TF64
GFSYAGSVAISGALA	DOT1L	936	Q8TEK3
SGAASVVLNVGGARY	KCNG3	6	Q8TAE7
GAGDSFVGALAFYLA	RBKS	266	Q9H477
AGYIEALAANAGTGF	APLP2	31	Q06481
VAAAAFAINGLSYGL	SLC16A11	41	Q8NCK7
GYTGANVRVAVFDTG	MBTPS1	206	Q14703
IATVGNTIYAVGGFD	IVNS1ABP	601	Q9Y6Y0
ALGYSFAAGTIDGVG	ASAH2	451	Q9NR71
GAALLAAGAGLAFYV	ICAM5	846	Q9UMF0
QVLEGSQVGAYFGSA	ITGA3	296	P26006
RGFGVAIVGNYTAAL	PGLYRP2	476	Q96PD5
GGAFIVGAASSYEGS	CES4A	141	Q5XG92
GYSQADVGIAVGALF	POU5F2	141	Q8N7G0
VAGSVLAGYNGTIFA	KIF6	81	Q6ZMV9
TRAAFLLGGAGVYAV	LANCL3	116	Q6ZV70
GVLVNYFGAAATFRG	MFSD6	591	Q6ZSS7
GATSAEAFLAAGYGV	PPCS	66	Q9HAB8
FGYAVAATDVNGDGL	ITGA5	326	P08648
SVAGEVVFNTGLGGY	CPS1	66	P31327
GEAAGAAADGIAAYS	GOLGA8K	521	D6RF30
YGAAFSAAPVGALAA	CHD3	1931	Q12873
FGRDFATGAVGQYTV	ALOX12B	41	O75342
EGRVFVYINSGSGAV	ITGA4	336	P13612
FVLTGAAGDKVYGAA	DENND4B	261	O75064
LSGAFVAGLDAGLVY	COX15	276	Q7KZN9
SIGGLFFAVGIAQYA	SLC22A15	201	Q8IZD6
AAYNGAGLGVFSRAV	SDK1	846	Q7Z5N4
AIATFGGAVAAFAVG	SLC19A3	321	Q9BZV2
GGAVAAFAVGYVKVN	SLC19A3	326	Q9BZV2
AFANTEGGYLFIGVD	SLFN13	236	Q68D06
SFAYAAGAGQLRAAV	CNTNAP3B	656	Q96NU0
IAIANAADVGLAGYF	ALDH5A1	456	P51649
AVYVGLLGGAAACFT	TIMM29	61	Q9BSF4
GLGAAAAAGEFAFAY	TMEM121B	301	Q9BXQ6
YAVLGFGAVLAAFGN	TAAR9	36	Q96RI9
AVAGALGAFVGSPAY	SLC25A34	111	Q6PIV7
NFSTIIGVGVGAGAY	NDRG2	136	Q9UN36
ASSAGVYFGPAAAVA	NKX6-2	86	Q9C056
VTVGGYGALFTAFQA	KYAT1	96	Q16773
EAAAAAAAAGVLYGG	MEX3C	176	Q5U5Q3
SAIATNGFVRGGGAY	SLC12A1	231	Q13621
GVGRYTAGAIASIAF	MUTYH	211	Q9UIF7
AAATRVVYDGGVFLG	PKHD1	876	P08F94
NAVAGAVKYSESAGG	NUP160	71	Q12769
AVLIGYGVSRAGAAF	ABCB7	191	O75027
TLGSVAGAVGATAVY	SLC25A12	331	O75746
AESAYRFGLGSVAGA	SLC25A13	326	Q9UJS0
ALVALAVAYGFTSGA	SLC16A13	306	Q7RTY0
AAAAAYGRSPVVGFD	TLE4	411	Q04727
VDVYAGFLIGAGIAA	PLPPR3	261	Q6T4P5
VAFVGGFSYADVLGS	PFAS	1111	O15067
ATGATRAVDGGFGYL	NIPAL4	86	Q0D2K0
YALIGTAVGVAISAG	TMEM273	36	Q5T292
AAAAAAALLYGTGGA	ZFP36L2	326	P47974
GAAAGAFYSGLLLAA	TMEM271	46	A0A286YF58
GAGYFAAVADAILRA	PLD2	341	O14939
SAIAAGVCGALFIGY	TOMM20	6	Q15388
VTFAVSFYLVAGAGG	TMEM127	171	O75204
SFYLVAGAGGASILA	TMEM127	176	O75204