Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondeaminase binding

HNRNPCL1 HNRNPC HNRNPCL2

1.19e-074633GO:1990827
GeneOntologyMolecularFunctiontelomerase RNA binding

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

1.08e-0625634GO:0070034
GeneOntologyMolecularFunctionDEAD/H-box RNA helicase binding

DROSHA SMAD1 SMAD5

2.48e-069633GO:0017151
GeneOntologyMolecularFunctionpoly(U) RNA binding

HNRNPCL1 ATXN1 HNRNPC HNRNPCL2

3.89e-0634634GO:0008266
GeneOntologyMolecularFunctionpoly-pyrimidine tract binding

HNRNPCL1 ATXN1 HNRNPC HNRNPCL2

6.81e-0639634GO:0008187
GeneOntologyMolecularFunctionN6-methyladenosine-containing RNA reader activity

HNRNPCL1 HNRNPC HNRNPCL2

1.33e-0515633GO:1990247
GeneOntologyMolecularFunctionprotein-RNA adaptor activity

HNRNPCL1 HNRNPC HNRNPCL2

5.78e-0524633GO:0140517
GeneOntologyMolecularFunctionbisphosphoglycerate mutase activity

PGAM4 PGAM1

5.85e-054632GO:0004082
GeneOntologyMolecularFunction2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

PGAM4 PGAM1

5.85e-054632GO:0046538
GeneOntologyMolecularFunctionphosphoglycerate mutase activity

PGAM4 PGAM1

5.85e-054632GO:0004619
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

FOXJ2 HOXA5 SOX3 HIVEP3 SOX15 MLXIPL MEF2B ZBTB7C E2F7 ZNF362 EP300 SMAD1 SMAD5

1.13e-0412446313GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

FOXJ2 HOXA5 SOX3 HIVEP3 SOX15 MLXIPL MEF2B ZBTB7C E2F7 ZNF362 EP300 SMAD1 SMAD5

1.40e-0412716313GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

FOXJ2 HOXA5 SOX3 HIVEP3 SOX15 MLXIPL MEF2B ZBTB7C E2F7 ZNF362 TAF1 EP300 SMAD1 SMAD5

1.45e-0414596314GO:0000977
GeneOntologyMolecularFunctionSMAD binding

DROSHA EP300 SMAD1 SMAD5

1.57e-0486634GO:0046332
GeneOntologyMolecularFunctionnuclear receptor binding

TRERF1 SMARCE1 TAF1 ARID1A EP300

3.09e-04187635GO:0016922
GeneOntologyMolecularFunctionacetyltransferase activity

LPCAT2 SMARCE1 TAF1 EP300

3.27e-04104634GO:0016407
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

FOXJ2 HOXA5 SOX3 SOX15 MLXIPL MEF2B SHOX SMAD1

3.63e-04560638GO:0001228
GeneOntologyMolecularFunctiontranscription coactivator activity

TRERF1 SMARCE1 BCL3 DCC ARID1A EP300

3.82e-04303636GO:0003713
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

FOXJ2 HOXA5 SOX3 SOX15 MLXIPL MEF2B SHOX SMAD1

3.90e-04566638GO:0001216
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

FOXJ2 HOXA5 SOX3 HIVEP3 SOX15 MLXIPL MEF2B ZBTB7C YLPM1 E2F7 SHOX SMAD1 SMAD5

3.92e-0414126313GO:0000981
GeneOntologyMolecularFunctionsingle-stranded RNA binding

HNRNPCL1 ATXN1 HNRNPC HNRNPCL2

4.19e-04111634GO:0003727
GeneOntologyMolecularFunctionprimary miRNA binding

DROSHA SMAD1

4.34e-0410632GO:0070878
GeneOntologyMolecularFunctionintramolecular phosphotransferase activity

PGAM4 PGAM1

5.29e-0411632GO:0016868
GeneOntologyMolecularFunctionI-SMAD binding

SMAD1 SMAD5

1.29e-0317632GO:0070411
GeneOntologyMolecularFunctiontranscription coregulator activity

TRERF1 SMARCE1 BCL3 DCC ARID1A MIDEAS EP300

1.91e-03562637GO:0003712
GeneOntologyMolecularFunctionN-acetyltransferase activity

SMARCE1 TAF1 EP300

1.92e-0378633GO:0008080
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

TRERF1 MLXIPL SMARCE1 TAF1 ARID1A EP300

1.99e-03417636GO:0061629
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

TRERF1 MLXIPL SMARCE1 TAF1 BCL3 ARID1A EP300

2.32e-03582637GO:0140297
GeneOntologyMolecularFunctiontranscription factor binding

TRERF1 MLXIPL PER3 SMARCE1 TAF1 BCL3 ARID1A EP300

2.44e-03753638GO:0008134
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

TRERF1 HNRNPCL1 SMARCE1 BCL3 DCC ARID1A MIDEAS HNRNPC EP300 HNRNPCL2

3.23e-0311606310GO:0030674
GeneOntologyMolecularFunctionnucleosome binding

SMARCE1 ARID1A HNRNPC

3.68e-0398633GO:0031491
GeneOntologyMolecularFunctionintramolecular transferase activity

PGAM4 PGAM1

3.77e-0329632GO:0016866
GeneOntologyMolecularFunctionN-acyltransferase activity

SMARCE1 TAF1 EP300

4.12e-03102633GO:0016410
GeneOntologyMolecularFunctionacetylation-dependent protein binding

TAF1 EP300

4.29e-0331632GO:0140033
GeneOntologyMolecularFunctionprotein domain specific binding

FZD7 HNRNPCL1 NF2 ATXN1 SHISA5 DENND1A HNRNPC HNRNPCL2

6.04e-03875638GO:0019904
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

LPCAT2 SMARCE1 TAF1 EP300

6.77e-03238634GO:0016747
GeneOntologyMolecularFunctionchromatin binding

SOX15 ATXN1 SMARCE1 TAF1 ARID1A HNRNPC EP300

8.47e-03739637GO:0003682
GeneOntologyMolecularFunctionmolecular adaptor activity

TRERF1 HNRNPCL1 SMARCE1 BCL3 DCC ARID1A MIDEAS HNRNPC EP300 HNRNPCL2

9.53e-0313566310GO:0060090
GeneOntologyMolecularFunctiontranscription coregulator binding

TRERF1 PER3 EP300

9.86e-03140633GO:0001221
GeneOntologyMolecularFunctionlipopolysaccharide binding

BPI DROSHA

1.01e-0248632GO:0001530
GeneOntologyMolecularFunctionhistone acetyltransferase activity

TAF1 EP300

1.13e-0251632GO:0004402
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

TRERF1 FOXJ2 HOXA5 SOX3 SOX15 MLXIPL WASL MEF2B PPP2R5D ZBTB7C ATXN1 E2F7 SHOX TAF1 BCL3 EP300 SMAD1 SMAD5

1.03e-0713906318GO:0045944
GeneOntologyBiologicalProcessnegative regulation of mRNA modification

HNRNPCL1 HNRNPC HNRNPCL2

5.40e-076633GO:0090367
GeneOntologyBiologicalProcessregulation of mRNA modification

HNRNPCL1 HNRNPC HNRNPCL2

9.42e-077633GO:0090365
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

TRERF1 SOX3 SOX15 MLXIPL PER3 ATXN1 YLPM1 E2F7 SMARCE1 TAF1 BCL3 ARID1A MIDEAS ZNF282 EP300 SMAD5

3.21e-0613996316GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

TRERF1 SOX3 SOX15 MLXIPL PER3 ATXN1 YLPM1 E2F7 SMARCE1 TAF1 BCL3 ARID1A MIDEAS ZNF282 EP300 SMAD5

3.65e-0614136316GO:1902679
GeneOntologyBiologicalProcessregulation of chromosome organization

HNRNPCL1 NAF1 YLPM1 SMARCE1 ARID1A HNRNPC HNRNPCL2

1.64e-05266637GO:0033044
GeneOntologyBiologicalProcessregulation of telomere maintenance

HNRNPCL1 NAF1 YLPM1 HNRNPC HNRNPCL2

2.36e-05112635GO:0032204
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomerase

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

3.39e-0560634GO:0032210
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomere lengthening

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

5.89e-0569634GO:1904356
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance via telomerase

HNRNPCL1 HNRNPC HNRNPCL2

5.95e-0525633GO:0032211
GeneOntologyBiologicalProcessmRNA modification

HNRNPCL1 HNRNPC HNRNPCL2

6.72e-0526633GO:0016556
GeneOntologyBiologicalProcesstelomere maintenance via telomerase

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

9.05e-0577634GO:0007004
GeneOntologyBiologicalProcess3'-UTR-mediated mRNA stabilization

HNRNPCL1 HNRNPC HNRNPCL2

1.15e-0431633GO:0070935
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

1.21e-0483634GO:0006278
GeneOntologyBiologicalProcessosteoblast fate commitment

SMAD1 SMAD5

1.37e-046632GO:0002051
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance via telomere lengthening

HNRNPCL1 HNRNPC HNRNPCL2

1.39e-0433633GO:1904357
GeneOntologyBiologicalProcessRNA stabilization

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

1.52e-0488634GO:0043489
GeneOntologyBiologicalProcesstelomere maintenance

HNRNPCL1 NAF1 YLPM1 HNRNPC HNRNPCL2

1.62e-04168635GO:0000723
GeneOntologyBiologicalProcesstelomere maintenance via telomere lengthening

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

1.66e-0490634GO:0010833
GeneOntologyBiologicalProcessnucleobase-containing compound catabolic process

PPP1R8 MLXIPL HNRNPCL1 NAF1 PGAM4 PGAM1 HNRNPC EP300 HNRNPCL2

2.50e-04696639GO:0034655
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

2.58e-04101634GO:1902369
GeneOntologyBiologicalProcessnegative regulation of catabolic process

USP30 HNRNPCL1 NAF1 TAF1 HNRNPC EP300 HNRNPCL2

2.78e-04418637GO:0009895
GeneOntologyBiologicalProcessregulation of G0 to G1 transition

SOX15 SMARCE1 ARID1A

2.86e-0442633GO:0070316
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance

HNRNPCL1 HNRNPC HNRNPCL2

2.86e-0442633GO:0032205
GeneOntologyBiologicalProcesssignal transduction by p53 class mediator

SHISA5 E2F7 TAF1 BCL3 EP300

2.94e-04191635GO:0072331
GeneOntologyBiologicalProcessregulation of DNA metabolic process

HNRNPCL1 NAF1 YLPM1 E2F7 SMARCE1 ARID1A HNRNPC HNRNPCL2

3.07e-04564638GO:0051052
GeneOntologyBiologicalProcessnegative regulation of DNA biosynthetic process

HNRNPCL1 HNRNPC HNRNPCL2

3.07e-0443633GO:2000279
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

SOX3 SOX15 MLXIPL PER3 ATXN1 YLPM1 E2F7 TAF1 ARID1A EP300 SMAD5

3.12e-0410536311GO:0000122
GeneOntologyBiologicalProcessG0 to G1 transition

SOX15 SMARCE1 ARID1A

3.29e-0444633GO:0045023
GeneOntologyBiologicalProcesstelomere organization

HNRNPCL1 NAF1 YLPM1 HNRNPC HNRNPCL2

3.55e-04199635GO:0032200
GeneOntologyBiologicalProcessglycolytic process

MLXIPL PGAM4 PGAM1 EP300

3.58e-04110634GO:0006096
GeneOntologyBiologicalProcessADP catabolic process

MLXIPL PGAM4 PGAM1 EP300

4.10e-04114634GO:0046032
GeneOntologyBiologicalProcesspurine nucleoside diphosphate catabolic process

MLXIPL PGAM4 PGAM1 EP300

4.53e-04117634GO:0009137
GeneOntologyBiologicalProcesspurine ribonucleoside diphosphate catabolic process

MLXIPL PGAM4 PGAM1 EP300

4.53e-04117634GO:0009181
GeneOntologyBiologicalProcessintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

SHISA5 BCL3 EP300

4.53e-0449633GO:0042771
GeneOntologyBiologicalProcesspyridine nucleotide catabolic process

MLXIPL PGAM4 PGAM1 EP300

4.82e-04119634GO:0019364
GeneOntologyBiologicalProcessADP metabolic process

MLXIPL PGAM4 PGAM1 EP300

4.98e-04120634GO:0046031
GeneOntologyBiologicalProcessribonucleoside diphosphate catabolic process

MLXIPL PGAM4 PGAM1 EP300

5.14e-04121634GO:0009191
GeneOntologyBiologicalProcesspyridine-containing compound catabolic process

MLXIPL PGAM4 PGAM1 EP300

5.47e-04123634GO:0072526
GeneOntologyBiologicalProcessformation of primary germ layer

FZD7 NF2 ARID1A SMAD1

5.64e-04124634GO:0001704
GeneOntologyBiologicalProcessnucleoside diphosphate catabolic process

MLXIPL PGAM4 PGAM1 EP300

5.64e-04124634GO:0009134
GeneOntologyBiologicalProcessstriated muscle tissue development

FZD7 SOX15 ARID1A EP300 SMAD1 SMAD5

6.78e-04349636GO:0014706
GeneOntologyBiologicalProcessglyceraldehyde-3-phosphate biosynthetic process

PGAM4 PGAM1

7.01e-0413632GO:0046166
GeneOntologyBiologicalProcesspurine nucleoside diphosphate metabolic process

MLXIPL PGAM4 PGAM1 EP300

7.13e-04132634GO:0009135
GeneOntologyBiologicalProcesspurine ribonucleoside diphosphate metabolic process

MLXIPL PGAM4 PGAM1 EP300

7.13e-04132634GO:0009179
GeneOntologyBiologicalProcessmyoblast differentiation

SOX15 SMARCE1 ARID1A MBNL3

7.97e-04136634GO:0045445
GeneOntologyBiologicalProcessregulation of DNA biosynthetic process

HNRNPCL1 NAF1 HNRNPC HNRNPCL2

8.42e-04138634GO:2000278
GeneOntologyBiologicalProcesspyruvate metabolic process

MLXIPL PGAM4 PGAM1 EP300

9.36e-04142634GO:0006090
GeneOntologyBiologicalProcessribonucleoside diphosphate metabolic process

MLXIPL PGAM4 PGAM1 EP300

9.61e-04143634GO:0009185
GeneOntologyBiologicalProcessT cell differentiation

FZD7 DROSHA SMARCE1 BCL3 ARID1A EP300

1.08e-03382636GO:0030217
GeneOntologyBiologicalProcessnucleoside diphosphate metabolic process

MLXIPL PGAM4 PGAM1 EP300

1.12e-03149634GO:0009132
GeneOntologyBiologicalProcessATP metabolic process

MLXIPL PGAM4 PGAM1 NDUFB7 EP300

1.13e-03257635GO:0046034
GeneOntologyBiologicalProcessmuscle structure development

FZD7 HIVEP3 SOX15 MEF2B SMARCE1 ARID1A EP300 MBNL3 SMAD1

1.13e-03858639GO:0061061
GeneOntologyBiologicalProcesscirculatory system development

FOXJ2 HOXA5 FZD7 JCAD COL8A1 MEF2B CNTRL E2F7 ARID1A EP300 SMAD1 SMAD5

1.24e-0314426312GO:0072359
GeneOntologyBiologicalProcesstrophoblast giant cell differentiation

SOX15 E2F7

1.52e-0319632GO:0060707
GeneOntologyBiologicalProcessmuscle tissue development

FZD7 HIVEP3 SOX15 ARID1A EP300 SMAD1 SMAD5

1.52e-03558637GO:0060537
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

FOXJ2 HOXA5 FZD7 JCAD COL8A1 NF2 E2F7 BCL3 ARID1A EP300 SMAD1 SMAD5

1.57e-0314836312GO:0048646
GeneOntologyCellularComponentnucleoplasmic periphery of the nuclear pore complex

HNRNPCL1 HNRNPC HNRNPCL2

5.18e-076633GO:1990826
GeneOntologyCellularComponentpronucleus

HNRNPCL1 TAF1 HNRNPC HNRNPCL2

1.45e-0628634GO:0045120
GeneOntologyCellularComponentnuclear protein-containing complex

TRERF1 PPP1R8 MLXIPL HNRNPCL1 SETD1B DROSHA E2F7 SMARCE1 TAF1 ARID1A MIDEAS HNRNPC HNRNPCL2 SMAD1 SMAD5

1.07e-0513776315GO:0140513
GeneOntologyCellularComponenttranscription regulator complex

TRERF1 SOX15 MLXIPL MEF2B E2F7 TAF1 MIDEAS EP300 SMAD1 SMAD5

1.08e-055966310GO:0005667
GeneOntologyCellularComponentchromatin

FOXJ2 HOXA5 SOX3 SOX15 MLXIPL MEF2B E2F7 SHOX SMARCE1 TAF1 ARID1A HNRNPC EP300 SMAD1 SMAD5

2.51e-0514806315GO:0000785
GeneOntologyCellularComponenttelomerase holoenzyme complex

HNRNPCL1 HNRNPC HNRNPCL2

5.72e-0525633GO:0005697
GeneOntologyCellularComponentheteromeric SMAD protein complex

SMAD1 SMAD5

2.47e-048632GO:0071144
GeneOntologyCellularComponentSMAD protein complex

SMAD1 SMAD5

3.96e-0410632GO:0071141
GeneOntologyCellularComponentbBAF complex

SMARCE1 ARID1A

3.96e-0410632GO:0140092
GeneOntologyCellularComponentnpBAF complex

SMARCE1 ARID1A

7.95e-0414632GO:0071564
GeneOntologyCellularComponentbrahma complex

SMARCE1 ARID1A

7.95e-0414632GO:0035060
GeneOntologyCellularComponentnBAF complex

SMARCE1 ARID1A

1.04e-0316632GO:0071565
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

MLXIPL E2F7 TAF1 SMAD1 SMAD5

1.37e-03272635GO:0090575
GeneOntologyCellularComponentcatalytic step 2 spliceosome

HNRNPCL1 HNRNPC HNRNPCL2

3.14e-0397633GO:0071013
GeneOntologyCellularComponentSWI/SNF complex

SMARCE1 ARID1A

3.68e-0330632GO:0016514
HumanPhenoHypoplastic fifth toenail

PPP2R5D SMARCE1 ARID1A

4.11e-0519193HP:0011937
HumanPhenoObesity

SOX3 MLXIPL NF2 SHOX SMARCE1 TAF1 DCC EP300

7.29e-05425198HP:0001513
HumanPhenoSleep abnormality

SOX3 MLXIPL PER3 NF2 ANXA11 SMARCE1 TAF1 HNRNPC EP300

1.21e-04596199HP:0002360
HumanPhenoDecreased circulating ACTH concentration

SOX3 NF2 SMARCE1

1.68e-0430193HP:0002920
HumanPhenoAbnormal prolactin level

SOX3 NF2 SMARCE1

1.68e-0430193HP:0040086
HumanPhenoThick eyebrow

SETD1B SMARCE1 TAF1 ARID1A EP300

1.95e-04154195HP:0000574
HumanPhenoIncreased body weight

SOX3 MLXIPL NF2 SHOX SMARCE1 TAF1 DCC EP300

2.04e-04491198HP:0004324
HumanPhenoAbnormal toenail morphology

PPP2R5D SHOX SMARCE1 TAF1 ARID1A

2.86e-04167195HP:0008388
HumanPhenoIntellectual disability, moderate

PPP2R5D SMARCE1 TAF1 ARID1A HNRNPC

3.28e-04172195HP:0002342
HumanPhenoPituitary hypothyroidism

SOX3 NF2 SMARCE1

3.42e-0438193HP:0008245
HumanPhenoHypogonadotropic hypogonadism

SOX3 NF2 RNF216 SMARCE1 DCC

3.94e-04179195HP:0000044
HumanPhenoSmall nail

MLXIPL PPP2R5D SHOX SMARCE1 ARID1A

4.37e-04183195HP:0001792
HumanPhenoMeningioma

NF2 SMARCE1 EP300

5.29e-0444193HP:0002858
HumanPhenoAbnormal circulating adrenocorticotropin concentration

SOX3 NF2 SMARCE1

5.29e-0444193HP:0011043
HumanPhenoAbnormal thalamus morphology

NF2 SMARCE1 DCC

6.85e-0448193HP:0010663
HumanPhenoAmenorrhea

SOX3 NF2 RNF216 SMARCE1 DCC

6.88e-04202195HP:0000141
HumanPhenoNeoplasm of the posterior pituitary

NF2 SMARCE1

7.11e-0411192HP:0011752
HumanPhenoFocal T2 hypointense thalamic lesion

NF2 SMARCE1

7.11e-0411192HP:0012691
HumanPhenoSpinal meningioma

NF2 SMARCE1

7.11e-0411192HP:0100010
HumanPhenoIntracranial meningioma

NF2 SMARCE1

7.11e-0411192HP:0100009
HumanPhenoAbnormal kinetic perimetry test

NF2 SMARCE1

7.11e-0411192HP:0030591
HumanPhenoSpinocerebellar tract degeneration

ATXN1 TDP1

7.11e-0411192HP:0002503
HumanPhenoAplastic/hypoplastic toenail

PPP2R5D SHOX SMARCE1 ARID1A

7.85e-04117194HP:0010624
HumanPhenoImpairment in personality functioning

MLXIPL PPP2R5D SETD1B PER3 NF2 ANXA11 RNF216 SMARCE1 TAF1 ARID1A EP300

8.48e-0411411911HP:0031466
HumanPhenoWeak extraocular muscles

NF2 SMARCE1

8.51e-0412192HP:0007715
HumanPhenoHypothalamic hypothyroidism

NF2 SMARCE1

8.51e-0412192HP:0008237
HumanPhenoHemifacial spasm

NF2 SMARCE1

8.51e-0412192HP:0010828
HumanPhenoAbnormal hypothalamus physiology

NF2 SMARCE1 DCC

9.16e-0453193HP:0012285
HumanPhenoHypoplastic fingernail

SHOX SMARCE1 ARID1A

9.16e-0453193HP:0001804
HumanPhenoDecreased pulmonary function

NF2 SMARCE1

1.00e-0313192HP:0005952
HumanPhenoProgressive pulmonary function impairment

NF2 SMARCE1

1.00e-0313192HP:0006520
HumanPhenoAbnormal fifth cranial nerve physiology

NF2 SMARCE1

1.00e-0313192HP:0031911
HumanPhenoChromosomal breakage induced by ionizing radiation

NF2 SMARCE1

1.00e-0313192HP:0010997
HumanPhenoAbnormality of the spinocerebellar tracts

ATXN1 TDP1

1.00e-0313192HP:0003133
HumanPhenoNeuralgia

NF2 SMARCE1

1.00e-0313192HP:0033345
HumanPhenoTrigeminal neuralgia

NF2 SMARCE1

1.00e-0313192HP:0100661
HumanPhenoAbnormal fifth cranial nerve morphology

NF2 SMARCE1

1.00e-0313192HP:0010824
HumanPhenoGaze-evoked nystagmus

SOX3 ATXN1 TDP1

1.02e-0355193HP:0000640
HumanPhenoAbnormal posterior pituitary morphogenesis

SOX3 NF2 SMARCE1

1.02e-0355193HP:0011751
HumanPhenoAbnormality of the sense of smell

SOX3 NF2 SMARCE1 DCC

1.07e-03127194HP:0004408
HumanPhenoThin upper lip vermilion

PPP2R5D SMARCE1 TAF1 ARID1A HNRNPC EP300

1.07e-03339196HP:0000219
HumanPhenoThin lips

PPP2R5D SMARCE1 TAF1 ARID1A HNRNPC EP300

1.07e-03339196HP:0000213
HumanPhenoLong eyelashes

SMARCE1 TAF1 ARID1A EP300

1.13e-03129194HP:0000527
HumanPhenoPrenatal growth deficiency

MLXIPL PPP2R5D SMARCE1 TAF1 ARID1A NDUFB7 HNRNPC EP300

1.14e-03631198HP:0001515
HumanPhenoIntrauterine growth retardation

MLXIPL PPP2R5D SMARCE1 TAF1 ARID1A NDUFB7 HNRNPC EP300

1.14e-03631198HP:0001511
HumanPhenoAbnormal central sensory function

NF2 SMARCE1

1.17e-0314192HP:0011730
HumanPhenoBrain stem compression

NF2 SMARCE1

1.17e-0314192HP:0002512
HumanPhenoIncreased sensitivity to ionizing radiation

NF2 SMARCE1

1.17e-0314192HP:0011133
HumanPhenoHypoplastic fifth fingernail

SMARCE1 ARID1A

1.17e-0314192HP:0008398
HumanPhenoEnlarged pituitary gland

NF2 SMARCE1

1.17e-0314192HP:0012505
HumanPhenoCerebellar malformation

MLXIPL ATXN1 SMARCE1 TAF1 TDP1 ARID1A EP300

1.27e-03487197HP:0002438
HumanPhenoSecondary growth hormone deficiency

NF2 SMARCE1

1.34e-0315192HP:0008240
HumanPhenoEar pain

NF2 SMARCE1

1.34e-0315192HP:0030766
HumanPhenoThick lower lip vermilion

MLXIPL SETD1B SMARCE1 ARID1A

1.38e-03136194HP:0000179
HumanPhenoUnsteady gait

PPP2R5D NF2 SMARCE1 DCC ARID1A EP300

1.41e-03357196HP:0002317
HumanPhenoHemiplegia/hemiparesis

SOX3 NF2 RNF216 SMARCE1 DCC

1.50e-03240195HP:0004374
HumanPhenoHeteronymous hemianopia

NF2 SMARCE1

1.53e-0316192HP:0030517
HumanPhenoBitemporal hemianopia

NF2 SMARCE1

1.53e-0316192HP:0030521
HumanPhenoSquare face

SETD1B EP300

1.53e-0316192HP:0000321
MousePhenoabnormal gastrulation

PPP1R8 WASL HNRNPCL1 NF2 YLPM1 ARID1A DENND1A HNRNPC EP300 HNRNPCL2 SMAD1 SMAD5

6.73e-084695012MP:0001695
MousePhenoabnormal developmental patterning

PPP1R8 WASL HNRNPCL1 NF2 YLPM1 ARID1A DENND1A HNRNPC EP300 HNRNPCL2 SMAD1 SMAD5

6.29e-075775012MP:0002084
MousePhenofailure to gastrulate

HNRNPCL1 NF2 YLPM1 ARID1A HNRNPC HNRNPCL2

3.92e-06119506MP:0001696
MousePhenoabsent heartbeat

WASL ARID1A DENND1A

9.37e-0525503MP:0004086
MousePhenoabnormal extraembryonic ectoderm morphology

PPP1R8 NF2 SMAD1

1.80e-0431503MP:0010736
DomainhnRNP_C

HNRNPCL1 HNRNPC HNRNPCL2

6.92e-076623IPR017347
DomainHMG_BOX_2

SOX3 SOX15 SMARCE1 TAF1

3.07e-0554624PS50118
DomainHMG_box_dom

SOX3 SOX15 MIA2 SMARCE1

6.40e-0565624IPR009071
DomainPhosphogly_mut1

PGAM4 PGAM1

6.48e-054622IPR005952
DomainDwarfin

SMAD1 SMAD5

3.00e-048622IPR013790
DomainDWB

SMAD1 SMAD5

3.00e-048622SM00524
DomainMH2

SMAD1 SMAD5

3.00e-048622PS51076
DomainMH1

SMAD1 SMAD5

3.00e-048622PS51075
Domain-

SMAD1 SMAD5

3.00e-0486223.90.520.10
DomainMAD_homology_MH1

SMAD1 SMAD5

3.00e-048622IPR013019
DomainMH2

SMAD1 SMAD5

3.00e-048622PF03166
DomainSMAD_dom_Dwarfin-type

SMAD1 SMAD5

3.00e-048622IPR001132
DomainPG/BPGM_mutase_AS

PGAM4 PGAM1

3.85e-049622IPR001345
DomainPGAM

PGAM4 PGAM1

4.80e-0410622SM00855
DomainPG_MUTASE

PGAM4 PGAM1

4.80e-0410622PS00175
DomainSMAD_FHA_domain

PPP1R8 SMAD1 SMAD5

6.86e-0452623IPR008984
DomainMAD_homology1_Dwarfin-type

SMAD1 SMAD5

7.00e-0412622IPR003619
DomainDWA

SMAD1 SMAD5

7.00e-0412622SM00523
DomainHis_Phos_1

PGAM4 PGAM1

7.00e-0412622PF00300
DomainHis_Pase_superF_clade-1

PGAM4 PGAM1

7.00e-0412622IPR013078
DomainMH1

SMAD1 SMAD5

7.00e-0412622PF03165
DomainHMG_box

SOX3 SOX15 SMARCE1

7.25e-0453623PF00505
DomainHMG

SOX3 SOX15 SMARCE1

7.66e-0454623SM00398
Domain-

SOX3 SOX15 SMARCE1

8.08e-04556231.10.30.10
DomainELM2

TRERF1 MIDEAS

8.26e-0413622PF01448
DomainELM2

TRERF1 MIDEAS

8.26e-0413622PS51156
DomainELM2_dom

TRERF1 MIDEAS

8.26e-0413622IPR000949
DomainELM2

TRERF1 MIDEAS

8.26e-0413622SM01189
DomainSMAD_dom-like

SMAD1 SMAD5

1.26e-0316622IPR017855
Domain-

SMAD1 SMAD5

1.26e-03166222.60.200.10
DomainHis_PPase_superfam

PGAM4 PGAM1

1.98e-0320622IPR029033
Domain-

PGAM4 PGAM1

1.98e-03206223.40.50.1240
DomainBromodomain_CS

TAF1 EP300

3.35e-0326622IPR018359
DomainSANT_dom

TRERF1 MIDEAS

3.35e-0326622IPR017884
DomainSANT

TRERF1 MIDEAS

3.88e-0328622PS51293
DomainRRM_1

HNRNPCL1 SETD1B HNRNPC HNRNPCL2

5.04e-03208624PF00076
DomainRRM

HNRNPCL1 SETD1B HNRNPC HNRNPCL2

5.84e-03217624SM00360
DomainMyb_DNA-binding

TRERF1 MIDEAS

6.01e-0335622PF00249
PathwayBIOCARTA_VDR_PATHWAY

SMARCE1 ARID1A EP300

4.79e-0522463MM1370
PathwayBIOCARTA_VDR_PATHWAY

SMARCE1 ARID1A EP300

6.27e-0524463M13404
PathwayREACTOME_RHOBTB2_GTPASE_CYCLE

HNRNPCL1 HNRNPC HNRNPCL2

7.11e-0525463MM15606
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

HNRNPCL1 HNRNPC HNRNPCL2

7.11e-0525463MM15608
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

HIVEP3 NUMBL EP300 SMAD1

1.44e-0482464MM15922
PathwayREACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN

SMARCE1 ARID1A EP300

1.81e-0434463MM15531
PathwayKEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY

SMAD1 SMAD5

2.16e-047462M47845
PathwayREACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS

MLXIPL PPP2R5D

2.16e-047462M26992
PathwayREACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN

SMARCE1 ARID1A EP300

2.34e-0437463M27797
PathwayREACTOME_RHOBTB_GTPASE_CYCLE

HNRNPCL1 HNRNPC HNRNPCL2

2.34e-0437463MM15683
PathwayKEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY

SMAD1 SMAD5

2.88e-048462M47847
PathwayKEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY

SMAD1 SMAD5

3.70e-049462M47844
PathwayKEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY

SMAD1 SMAD5

3.70e-049462M47822
PathwayBIOCARTA_HSWI_SNF_PATHWAY

SMARCE1 ARID1A

4.61e-0410462MM1532
PathwayPID_ALK2_PATHWAY

SMAD1 SMAD5

5.62e-0411462M203
PathwayKEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY

SMAD1 SMAD5

5.62e-0411462M47848
PathwayBIOCARTA_HSWI_SNF_PATHWAY

SMARCE1 ARID1A

6.73e-0412462M22006
PathwayWP_TGFBETA_SIGNALING_PATHWAY

EP300 SMAD1 SMAD5

6.80e-0453463MM15880
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

EP300 SMAD1 SMAD5

7.58e-0455463M39351
PathwayWP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION

SMAD1 SMAD5

7.94e-0413462M39378
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

HNRNPCL1 HNRNPC HNRNPCL2

8.85e-0458463MM15149
PathwayREACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING

WASL DCC

9.25e-0414462M889
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

EP300 SMAD1 SMAD5

9.30e-0459463M39886
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

SMARCE1 ARID1A EP300

1.23e-0365463M39682
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

SETD1B SMARCE1 ARID1A EP300

1.53e-03153464MM15522
Pubmed

A census of human transcription factors: function, expression and evolution.

TRERF1 FOXJ2 HOXA5 SOX3 HIVEP3 SOX15 MLXIPL E2F7 SHOX MIDEAS ZNF282 MBNL3 SMAD1 SMAD5

7.06e-10908631419274049
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TRERF1 FOXJ2 SOX3 HIVEP3 SOX15 PER3 ATXN1 SMARCE1 BCL3 ARID1A ZNF282 MBNL3 SMAD1

1.87e-09808631320412781
Pubmed

N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.

HNRNPCL1 HNRNPC HNRNPCL2

2.26e-08463336681355
Pubmed

The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells.

HNRNPCL1 HNRNPC HNRNPCL2

2.26e-08463323831410
Pubmed

hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability.

HNRNPCL1 HNRNPC HNRNPCL2

2.26e-08463310805751
Pubmed

hnRNPC induces isoform shifts in miR-21-5p leading to cancer development.

HNRNPCL1 HNRNPC HNRNPCL2

2.26e-08463335729324
Pubmed

A method to identify cDNAs based on localization of green fluorescent protein fusion products.

HNRNPCL1 YLPM1 HNRNPC HNRNPCL2

2.29e-081763410716735
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRERF1 ATXN1 YLPM1 SMARCE1 ZNF362 TAF1 ARID1A MIDEAS

3.01e-0826863833640491
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

FOXJ2 SETD1B PER3 NUMBL RNF216 R3HDM1 ARID1A EP300

4.58e-0828363818854154
Pubmed

Heterogeneous nuclear ribonucleoprotein C1 may control miR-30d levels in endometrial exosomes affecting early embryo implantation.

HNRNPCL1 HNRNPC HNRNPCL2

5.65e-08563329846695
Pubmed

Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene.

HNRNPCL1 HNRNPC HNRNPCL2

5.65e-0856339128719
Pubmed

Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism.

HNRNPCL1 HNRNPC HNRNPCL2

5.65e-08563325809670
Pubmed

Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease.

HNRNPCL1 HNRNPC HNRNPCL2

1.13e-07663326048669
Pubmed

Selective disruption of genes expressed in totipotent embryonal stem cells.

HNRNPCL1 HNRNPC HNRNPCL2

1.13e-0766331317320
Pubmed

Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.

HNRNPCL1 HNRNPC HNRNPCL2

1.13e-07663315687492
Pubmed

Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis.

HNRNPCL1 HNRNPC HNRNPCL2

1.13e-07663318363099
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

TRERF1 HNRNPCL1 SMARCE1 ARID1A HNRNPC HNRNPCL2

1.73e-0713563631077711
Pubmed

Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.

HNRNPCL1 HNRNPC HNRNPCL2

1.97e-07763325846207
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

JCAD WASL MIA2 NF2 DROSHA YLPM1 RNF216 SMARCE1 TAF1 R3HDM1 ARID1A NDUFB7 EP300

4.22e-071285631335914814
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

SMARCE1 ZNF362 ARID1A MIDEAS EP300

4.32e-078363528794006
Pubmed

Bone morphogenetic protein-2 stimulates Runx2 acetylation.

EP300 SMAD1 SMAD5

4.72e-07963316613856
Pubmed

Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization.

HNRNPCL1 HNRNPC HNRNPCL2

4.72e-07963310452948
Pubmed

Interaction between nucleosome assembly protein 1-like family members.

HNRNPCL1 HNRNPC HNRNPCL2

1.23e-061263321333655
Pubmed

The biogenesis of the coiled body during early mouse development.

HNRNPCL1 HNRNPC HNRNPCL2

1.23e-06126337768196
Pubmed

The DNA sequence and analysis of human chromosome 14.

MIA2 MAPK1IP1L YLPM1 TDP1 MIDEAS

1.83e-0611163512508121
Pubmed

Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.

NUMBL SMAD1 SMAD5

2.03e-061463322865640
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

MLXIPL HNRNPCL1 PER3 NF2 ARID1A HNRNPC HNRNPCL2

2.10e-0632663717015433
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

MLXIPL NUMBL DROSHA NAF1 RNF216 SMARCE1 R3HDM1 DENND1A HNRNPC SMAD1 SMAD5

2.36e-061038631126673895
Pubmed

SMAD proteins control DROSHA-mediated microRNA maturation.

DROSHA SMAD1 SMAD5

2.54e-061563318548003
Pubmed

BMP signaling dynamics in embryonic orofacial tissue.

SMAD1 SMAD5

3.23e-06263218446813
Pubmed

Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization.

SMAD1 SMAD5

3.23e-06263221723296
Pubmed

Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro.

SMAD1 SMAD5

3.23e-06263224297369
Pubmed

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.

SMAD1 SMAD5

3.23e-06263226711875
Pubmed

The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling.

SMAD1 SMAD5

3.23e-06263211451566
Pubmed

Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue.

PGAM4 PGAM1

3.23e-06263235521515
Pubmed

A single nucleotide polymorphism within the novel sex-linked testis-specific retrotransposed PGAM4 gene influences human male fertility.

PGAM4 PGAM1

3.23e-06263222590500
Pubmed

PGAM1 is Involved in Spermatogenic Dysfunction and Affects Cell Proliferation, Apoptosis, and Migration.

PGAM4 PGAM1

3.23e-06263225701843
Pubmed

Gene network of a phosphoglycerate mutase in muscle wasting in mice.

PGAM4 PGAM1

3.23e-06263225644094
Pubmed

PGAM1 knockdown is associated with busulfan‑induced hypospermatogenesis and spermatogenic cell apoptosis.

PGAM4 PGAM1

3.23e-06263230720109
Pubmed

BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.

SMAD1 SMAD5

3.23e-06263232210087
Pubmed

Phosphoglycerate Mutase 1 Promotes Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus by Facilitating the Phosphorylation of cAMP Response Element-Binding Protein.

PGAM4 PGAM1

3.23e-06263230460638
Pubmed

Brachymesomelic dysplasia with Peters anomaly of the eye results from disruptions of the X chromosome near the SHOX and SOX3 genes.

SOX3 SHOX

3.23e-06263217994562
Pubmed

T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.

PGAM4 PGAM1

3.23e-06263232709928
Pubmed

BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow.

SMAD1 SMAD5

3.23e-06263223387849
Pubmed

The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function.

WASL NF2

3.23e-06263215699051
Pubmed

A precise localization of a mouse gene encoding increased phosphoglycerate mutase activity (Pgam1e1) on chromosome 19.

PGAM4 PGAM1

3.23e-0626328829551
Pubmed

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

SMAD1 SMAD5

3.23e-0626328799132
Pubmed

Interaction network of human early embryonic transcription factors.

TRERF1 ATXN1 SMARCE1 TAF1 ARID1A MIDEAS EP300

3.42e-0635163738297188
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

HNRNPCL1 NF2 SMARCE1 DCC HNRNPC EP300 HNRNPCL2

4.27e-0636363714691545
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

FOXJ2 HOXA5 SOX3 MEF2B E2F7 SHOX ZNF282 SMAD5

6.19e-0654463828473536
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NF2 YLPM1 SMARCE1 TAF1 PATJ ARID1A MIDEAS EP300

6.62e-0654963838280479
Pubmed

Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina.

DCC SMAD1 SMAD5

7.36e-062163321273545
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

HNRNPCL1 ANXA11 YLPM1 SMARCE1 ZNF362 TAF1 ARID1A MIDEAS HNRNPC HNRNPCL2

7.88e-06954631036373674
Pubmed

Human transcription factor protein interaction networks.

TRERF1 HOXA5 SOX15 ATXN1 YLPM1 SMARCE1 TAF1 R3HDM1 ARID1A MIDEAS EP300 SMAD5

8.45e-061429631235140242
Pubmed

Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.

SMAD1 SMAD5

9.68e-06363210652350
Pubmed

Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.

PGAM4 PGAM1

9.68e-06363233914812
Pubmed

Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.

SMAD1 SMAD5

9.68e-06363230953749
Pubmed

BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity.

EP300 SMAD1

9.68e-06363220851880
Pubmed

Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.

SMAD1 SMAD5

9.68e-06363232720893
Pubmed

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.

SMAD1 SMAD5

9.68e-06363229376829
Pubmed

Molecular cloning and nucleotide sequence of murine 2,3-bisphosphoglycerate mutase cDNA.

PGAM4 PGAM1

9.68e-0636322847721
Pubmed

Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.

SMAD1 SMAD5

9.68e-06363221381028
Pubmed

Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.

SMAD1 SMAD5

9.68e-06363220371744
Pubmed

Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis.

PGAM4 PGAM1

9.68e-06363232634742
Pubmed

Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping.

PGAM4 PGAM1

9.68e-06363211250083
Pubmed

BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells.

SMAD1 SMAD5

9.68e-06363215246821
Pubmed

BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors.

SMAD1 SMAD5

9.68e-06363222964636
Pubmed

TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.

SMAD1 SMAD5

9.68e-06363225505291
Pubmed

Activation of Smad1-mediated transcription by p300/CBP.

EP300 SMAD1

9.68e-06363210673036
Pubmed

Fluoride promotes viability and differentiation of osteoblast-like Saos-2 cells via BMP/Smads signaling pathway.

SMAD1 SMAD5

9.68e-06363223918166
Pubmed

Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.

SMAD1 SMAD5

9.68e-06363224023003
Pubmed

Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.

SMAD1 SMAD5

9.68e-06363227848974
Pubmed

Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

SMAD1 SMAD5

9.68e-06363220522807
Pubmed

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains.

PGAM4 PGAM1

9.68e-06363224958256
Pubmed

PGAM1 deficiency ameliorates myocardial infarction remodeling by targeting TGF-β via the suppression of inflammation, apoptosis and fibrosis.

PGAM4 PGAM1

9.68e-06363233168191
Pubmed

Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.

SMAD1 SMAD5

9.68e-06363231127639
Pubmed

Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.

SMAD1 SMAD5

9.68e-06363222897816
Pubmed

The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice.

PGAM4 PGAM1

9.68e-06363237028703
Pubmed

TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.

SMAD1 SMAD5

9.68e-06363219096363
Pubmed

BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling.

SMAD1 SMAD5

9.68e-06363233463047
Pubmed

Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.

SMAD1 SMAD5

9.68e-06363221945631
Pubmed

Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins.

SMAD1 SMAD5

9.68e-06363214711801
Pubmed

Molecular Interaction Between Smurfl WW2 Domain and PPXY Motifs of Smadl, Smad5, and Smad6-Modeling and Analysis.

SMAD1 SMAD5

9.68e-06363222670624
Pubmed

Developmental activation of phosphoglycerate mutase-2 in the testis of the mouse.

PGAM4 PGAM1

9.68e-0636322824255
Pubmed

Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.

SMAD1 SMAD5

9.68e-06363230367512
Pubmed

A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.

TRERF1 EP300

9.68e-06363211349124
Pubmed

Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

PGAM4 PGAM1

9.68e-06363220847263
Pubmed

Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line.

SMAD1 SMAD5

9.68e-06363225165122
Pubmed

Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage.

SMAD1 SMAD5

9.68e-06363212649288
Pubmed

Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation.

SMAD1 SMAD5

9.68e-06363225880873
Pubmed

Two chromatin remodeling activities cooperate during activation of hormone responsive promoters.

SMARCE1 ARID1A

9.68e-06363219609353
Pubmed

Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.

SMAD1 SMAD5

9.68e-06363216247476
Pubmed

DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina.

DCC SMAD1 SMAD5

9.78e-062363320875817
Pubmed

Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.

COL8A1 SMAD1 SMAD5

9.78e-062363328190640
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TRERF1 JCAD MIA2 YLPM1 PATJ HNRNPC SMAD1

1.28e-0543063735044719
Pubmed

Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein.

HNRNPCL1 PGAM4 PGAM1 HNRNPC HNRNPCL2

1.43e-0516963523665500
Pubmed

Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.

HNRNPCL1 HNRNPC HNRNPCL2

1.43e-052663315890332
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

JCAD PPP2R5D NF2 R3HDM1 PATJ ARID1A DENND1A

1.62e-0544663724255178
Pubmed

Single-cell analysis identifies a key role for Hhip in murine coronal suture development.

COL8A1 SMAD1 SMAD5

1.80e-052863334880220
Pubmed

Msx1 is essential for proper rostral tip formation of the mouse mandible.

SMAD1 SMAD5

1.93e-05463236566565
InteractionSS18L1 interactions

USP30 MIA2 MAPK1IP1L NAF1 SMARCE1 ARID1A EP300 SMAD1

7.27e-1098638int:SS18L1
InteractionPDCD6 interactions

VPS37C MIA2 NF2 ATXN1 DROSHA MAPK1IP1L ANXA11 SMARCE1 ARID1A

1.38e-08204639int:PDCD6
InteractionPAX6 interactions

SOX3 ATXN1 SMARCE1 TAF1 PATJ ARID1A MIDEAS HNRNPC EP300 SMAD1 SMAD5

1.61e-083666311int:PAX6
InteractionYAP1 interactions

TRERF1 JCAD WASL HNRNPCL1 NF2 DROSHA YLPM1 SMARCE1 TAF1 PATJ ARID1A MIDEAS PGAM1 HNRNPC EP300 SMAD1 SMAD5

2.61e-0810956317int:YAP1
InteractionDDIT3 interactions

HOXA5 VPS37C MLXIPL SMARCE1 ARID1A EP300

2.02e-06120636int:DDIT3
InteractionTLE3 interactions

TRERF1 FOXJ2 SOX15 ATXN1 RNF216 ZNF362 ARID1A MIDEAS EP300

2.42e-06376639int:TLE3
InteractionKLF1 interactions

VPS37C SMARCE1 ARID1A EP300

5.30e-0637634int:KLF1
InteractionSMAD1 interactions

HOXA5 SMARCE1 TAF1 ARID1A EP300 SMAD1 SMAD5

1.06e-05243637int:SMAD1
InteractionCRX interactions

TRERF1 SOX3 VPS37C ATXN1 ARID1A MIDEAS EP300

1.41e-05254637int:CRX
InteractionSOX3 interactions

SOX3 NF2 ATXN1

2.30e-0518633int:SOX3
InteractionARID1A interactions

SOX15 ATXN1 SMARCE1 ARID1A HNRNPC EP300 SMAD1

2.41e-05276637int:ARID1A
InteractionMYOD1 interactions

MLXIPL SMARCE1 ARID1A MIDEAS EP300 SMAD1

3.17e-05194636int:MYOD1
InteractionSP7 interactions

TRERF1 ATXN1 YLPM1 SMARCE1 ARID1A MIDEAS EP300

4.45e-05304637int:SP7
InteractionHNRNPCL3 interactions

HNRNPCL1 HNRNPC HNRNPCL2

4.93e-0523633int:HNRNPCL3
InteractionPAX9 interactions

VPS37C ATXN1 ARID1A MIDEAS EP300

5.38e-05130635int:PAX9
InteractionERG interactions

ATXN1 SMARCE1 ARID1A MIDEAS HNRNPC EP300

6.89e-05223636int:ERG
InteractionMEN1 interactions

COL8A1 PPP2R5D SETD1B DROSHA YLPM1 SMARCE1 TAF1 ARID1A MIDEAS HNRNPC SMAD1 SMAD5

7.03e-0510296312int:MEN1
InteractionFAM168A interactions

VPS37C FAM168B ATXN1 NAF1 RNF216

8.19e-05142635int:FAM168A
InteractionSOX2 interactions

TRERF1 HOXA5 SOX3 COL8A1 PPP2R5D NF2 ATXN1 YLPM1 SMARCE1 ZNF362 ARID1A MIDEAS HNRNPC EP300

1.00e-0414226314int:SOX2
InteractionEYA4 interactions

FOXJ2 SOX15 MAPK1IP1L R3HDM1 MIDEAS EP300

1.11e-04243636int:EYA4
InteractionRAMAC interactions

VPS37C FAM168B MAPK1IP1L NAF1

1.26e-0482634int:RAMAC
InteractionHOXD13 interactions

FOXJ2 SOX15 SMAD1 SMAD5

1.26e-0482634int:HOXD13
InteractionARHGEF25 interactions

PGAM4 SMARCE1 PGAM1

1.35e-0432633int:ARHGEF25
InteractionTBP interactions

FOXJ2 NF2 NAF1 TAF1 BCL3 EP300

1.38e-04253636int:TBP
InteractionHDAC1 interactions

TRERF1 NF2 ATXN1 SMARCE1 TAF1 BCL3 ARID1A MIDEAS HNRNPC EP300 SMAD1 SMAD5

1.42e-0411086312int:HDAC1
InteractionTMC5 interactions

NUMBL EP300

1.43e-046632int:TMC5
InteractionFSBP interactions

HNRNPC HNRNPCL2

1.43e-046632int:FSBP
InteractionTRERF1 interactions

TRERF1 MIDEAS EP300

1.49e-0433633int:TRERF1
InteractionMOV10 interactions

SOX15 HNRNPCL1 NF2 RNF216 SMARCE1 TAF1 R3HDM1 TDP1 ARID1A HNRNPC EP300 MBNL3 HNRNPCL2

1.56e-0412976313int:MOV10
InteractionGSC interactions

ATXN1 MIDEAS EP300 SMAD1

1.59e-0487634int:GSC
InteractionDROSHA interactions

DROSHA YLPM1 HNRNPCL2 SMAD5

1.59e-0487634int:DROSHA
InteractionHSFY1 interactions

SOX15 ATXN1 E2F7

1.63e-0434633int:HSFY1
InteractionKMT2D interactions

SOX15 SETD1B TAF1 EP300 SMAD1

1.85e-04169635int:KMT2D
InteractionPRMT2 interactions

WASL SETD1B YLPM1 R3HDM1

1.89e-0491634int:PRMT2
InteractionEGR2 interactions

TRERF1 ATXN1 ARID1A MIDEAS EP300

1.96e-04171635int:EGR2
InteractionFOXI1 interactions

VPS37C FAM168B ARID1A EP300

1.97e-0492634int:FOXI1
InteractionGDF6 interactions

SMAD1 SMAD5

2.00e-047632int:GDF6
InteractionSOX17 interactions

HOXA5 SMARCE1 ARID1A MIDEAS

2.23e-0495634int:SOX17
InteractionDNTTIP1 interactions

TRERF1 FOXJ2 SOX15 MIDEAS

2.23e-0495634int:DNTTIP1
InteractionTEAD1 interactions

MEF2B ATXN1 ARID1A MIDEAS EP300

2.24e-04176635int:TEAD1
InteractionEMB interactions

PER3 LPCAT2 EP300

2.27e-0438633int:EMB
InteractionAR interactions

TRERF1 ATXN1 YLPM1 SMARCE1 ZNF362 TAF1 DCC ARID1A MIDEAS EP300 SMAD1

2.28e-049926311int:AR
InteractionWWP2 interactions

VPS37C NF2 DROSHA YLPM1 C3orf70 SMARCE1 PATJ ARID1A MIDEAS HNRNPC

2.58e-048406310int:WWP2
InteractionTHPO interactions

NUMBL EP300

2.66e-048632int:THPO
InteractionSMARCE1 interactions

ATXN1 SMARCE1 ARID1A HNRNPC EP300 SMAD1

2.72e-04287636int:SMARCE1
InteractionLHX3 interactions

ATXN1 TAF1 DCC ARID1A MIDEAS

2.82e-04185635int:LHX3
InteractionSMAD5 interactions

DROSHA EP300 SMAD1 SMAD5

2.82e-04101634int:SMAD5
InteractionACTL6A interactions

ATXN1 SMARCE1 ARID1A HNRNPC EP300 SMAD1

2.83e-04289636int:ACTL6A
InteractionGATA4 interactions

HOXA5 MLXIPL YLPM1 SMARCE1 ARID1A EP300 SMAD1

2.88e-04411637int:GATA4
InteractionNFIA interactions

SOX15 ATXN1 ARID1A MIDEAS EP300

3.04e-04188635int:NFIA
InteractionSNIP1 interactions

HOXA5 COL8A1 SMARCE1 ARID1A HNRNPC EP300 SMAD1

3.15e-04417637int:SNIP1
InteractionHNF1B interactions

SOX15 ATXN1 ARID1A MIDEAS EP300

3.19e-04190635int:HNF1B
InteractionQKI interactions

USP30 HNRNPCL1 ATXN1 HNRNPC HNRNPCL2

3.19e-04190635int:QKI
InteractionGLIS2 interactions

SOX3 FAM168B NF2 SHOX

3.39e-04106634int:GLIS2
InteractionEN1 interactions

ATXN1 DROSHA MIDEAS EP300

3.91e-04110634int:EN1
InteractionGATA2 interactions

ATXN1 SMARCE1 ARID1A MIDEAS EP300

3.94e-04199635int:GATA2
InteractionRARB interactions

SMARCE1 ARID1A EP300

4.02e-0446633int:RARB
InteractionPAX8 interactions

ATXN1 ARID1A MIDEAS EP300

4.04e-04111634int:PAX8
InteractionFEV interactions

ATXN1 TAF1 ARID1A MIDEAS EP300

4.32e-04203635int:FEV
InteractionTBR1 interactions

ATXN1 ARID1A MIDEAS EP300

4.33e-04113634int:TBR1
InteractionUPF1 interactions

HOXA5 SOX15 HNRNPCL1 ATXN1 CNTRL E2F7 HNRNPC EP300

4.36e-04581638int:UPF1
InteractionLDB1 interactions

SOX15 ATXN1 TAF1 EP300

4.62e-04115634int:LDB1
InteractionPRPF40A interactions

HOXA5 WASL ATXN1 YLPM1 SMARCE1 HNRNPC EP300

4.71e-04446637int:PRPF40A
InteractionTBXT interactions

ATXN1 ARID1A MIDEAS EP300

4.78e-04116634int:TBXT
InteractionKRTAP19-7 interactions

VPS37C COL8A1 MAPK1IP1L NAF1

4.94e-04117634int:KRTAP19-7
InteractionNFIC interactions

SOX3 SOX15 ATXN1 ARID1A MIDEAS

5.04e-04210635int:NFIC
InteractionRUNX1 interactions

VPS37C SMARCE1 ARID1A EP300 SMAD1 SMAD5

5.18e-04324636int:RUNX1
InteractionMAGEB18 interactions

MIA2 ATXN1

5.19e-0411632int:MAGEB18
InteractionCASD1 interactions

PGAM4 PGAM1

5.19e-0411632int:CASD1
InteractionCREBBP interactions

TRERF1 PPP1R8 ATXN1 CNTRL BCL3 ARID1A EP300 SMAD1

5.34e-04599638int:CREBBP
InteractionPAX7 interactions

ATXN1 ARID1A MIDEAS EP300

6.14e-04124634int:PAX7
InteractionCDC40 interactions

HNRNPCL1 HNRNPC EP300 HNRNPCL2

6.14e-04124634int:CDC40
InteractionCHD4 interactions

FOXJ2 MLXIPL ATXN1 YLPM1 SMARCE1 ARID1A PGAM1 HNRNPC EP300 HNRNPCL2

6.16e-049386310int:CHD4
InteractionZNF804A interactions

ATXN1 HNRNPC

6.22e-0412632int:ZNF804A
InteractionRUNX2 interactions

HIVEP3 EP300 SMAD1 SMAD5

6.52e-04126634int:RUNX2
InteractionNFIX interactions

SOX15 ATXN1 SMARCE1 ARID1A MIDEAS

7.17e-04227635int:NFIX
InteractionKLF3 interactions

ATXN1 TAF1 ARID1A MIDEAS EP300

7.31e-04228635int:KLF3
InteractionFOXC1 interactions

FOXJ2 SOX15 SMARCE1 ARID1A EP300

7.31e-04228635int:FOXC1
InteractionHNRNPC interactions

HNRNPCL1 PPP2R5D ATXN1 SMARCE1 ARID1A HNRNPC EP300 HNRNPCL2

7.74e-04634638int:HNRNPC
InteractionKSR1 interactions

NF2 TAF1 DENND1A HNRNPCL2

7.77e-04132634int:KSR1
InteractionCTR9 interactions

PPP2R5D ATXN1 NAF1 EP300 HNRNPCL2

8.06e-04233635int:CTR9
InteractionSMARCC2 interactions

ATXN1 YLPM1 SMARCE1 ARID1A HNRNPC EP300

8.12e-04353636int:SMARCC2
InteractionGAA interactions

VPS37C NUMBL ATXN1 EP300

8.45e-04135634int:GAA
GeneFamilyBisphosphoglycerate phosphatases

PGAM4 PGAM1

4.13e-0544821082
GeneFamilySMAD family

SMAD1 SMAD5

1.91e-048482750
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

TAF1 EP300

9.15e-0417482486
GeneFamilySRY-boxes

SOX3 SOX15

1.15e-0319482757
CoexpressionGSE40274_FOXP3_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

PPP2R5D IGSF9 ZNF362 BCL3 PATJ MBNL3

9.23e-06199646M9180
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PCED1A HIVEP3 NUMBL DCC ZNF282

3.76e-061636450ab043b68e8739adcedda01165a3758cd0d22728
DrugPramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A

NF2 CNTRL ZNF362 TAF1 ARID1A MBNL3 SMAD5

1.01e-061926376054_DN
DrugDelcorine; Down 200; 8.4uM; MCF7; HT_HG-U133A

COL8A1 PER3 NF2 ZNF362 BCL3 ZNF282 SMAD1

1.28e-061996376033_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A ZNF282 EP300 SMAD1

7.84e-061716366879_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B TAF1 BCL3 PATJ ARID1A SMAD1

8.10e-061726365903_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA

SETD1B BCL3 ARID1A ZNF282 EP300 SMAD1

8.94e-061756361014_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SETD1B NF2 BCL3 ARID1A EP300 SMAD1

9.54e-061776363227_DN
DrugAlprostadil [745-65-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A

SOX3 PER3 NF2 ANXA11 CNTRL PATJ

1.75e-051976367358_UP
DrugEtilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A

FZD7 PER3 NF2 ANXA11 BCL3 MBNL3

1.75e-051976367350_UP
DrugQuinic acid [86-68-0]; Down 200; 19.6uM; MCF7; HT_HG-U133A

COL8A1 MIA2 NF2 ATXN1 CNTRL ARID1A

1.80e-051986363540_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A ZNF282 SMAD1

8.89e-051636355594_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SETD1B NF2 BCL3 ARID1A SMAD1

9.15e-051646354388_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

9.42e-051656355625_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

HIVEP3 SETD1B BCL3 ARID1A SMAD1

9.97e-051676353979_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

BCL3 ARID1A ZNF282 EP300 SMAD1

1.03e-041686353868_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.05e-041696355231_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

SETD1B BCL3 ARID1A EP300 SMAD1

1.08e-041706351050_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.08e-041706357043_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA

SETD1B BCL3 ARID1A EP300 SMAD1

1.11e-041716351000_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA

SETD1B BCL3 ARID1A EP300 SMAD1

1.14e-041726351072_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SETD1B ARID1A ZNF282 EP300 SMAD1

1.18e-041736354237_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A ZNF282 SMAD1

1.21e-041746356579_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

PPP1R8 TAF1 ARID1A EP300 SMAD1

1.21e-041746355745_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A ZNF282 SMAD1

1.21e-041746353462_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.21e-041746351659_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.24e-041756355935_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA

SETD1B BCL3 ARID1A EP300 SMAD1

1.24e-041756351058_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

FOXJ2 SETD1B BCL3 ARID1A SMAD1

1.24e-041756356891_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

FOXJ2 SETD1B BCL3 ARID1A SMAD1

1.28e-041766356932_DN
Drugtrichostatin A ; Down 200; 1uM; MCF7; HT_HG-U133A_EA

PPP1R8 SETD1B BCL3 ARID1A SMAD1

1.31e-04177635873_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.31e-041776351645_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.31e-041776356434_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

PPP1R8 SETD1B ARID1A ZNF282 SMAD1

1.31e-041776355308_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

FOXJ2 SETD1B ARID1A EP300 SMAD1

1.31e-041776357047_DN
Drugpararosaniline base; Up 200; 10uM; MCF7; HT_HG-U133A_EA

VPS37C ATXN1 SMARCE1 PATJ SMAD5

1.31e-04177635893_UP
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

BCL3 PATJ ARID1A EP300 SMAD1

1.31e-041776357550_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.34e-041786354710_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SETD1B BCL3 ARID1A EP300 SMAD1

1.45e-041816356951_DN
Drug5-methoxypsoralen

SMAD1 SMAD5

1.57e-047632ctd:C022909
Drugbp G

BPI PGAM4 PGAM1

1.72e-0439633CID000448110
Drug2-propylpentanoic acid; Down 200; 10000uM; MCF7; HG-U133A

HIVEP3 PPP1R8 SETD1B BCL3 SMAD1

1.74e-04188635345_DN
Drugradicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A

FZD7 HIVEP3 ANXA11 CNTRL PATJ

1.82e-041906356979_UP
DrugAspartic acid, N-acetyl (R,S) [997-55-7]; Up 200; 22.8uM; MCF7; HT_HG-U133A

JCAD COL8A1 NF2 DCC SMAD1

1.96e-041936354125_UP
DrugHymecromone [90-33-5]; Down 200; 22.8uM; PC3; HT_HG-U133A

FZD7 PPP2R5D PER3 NF2 BCL3

1.96e-041936354623_DN
DrugSolasodine [126-17-0]; Down 200; 9.6uM; PC3; HT_HG-U133A

WASL YLPM1 TAF1 R3HDM1 SMAD5

1.96e-041936354305_DN
Drug5248896; Up 200; 11uM; MCF7; HT_HG-U133A_EA

HOXA5 WASL ATXN1 BCL3 PATJ

2.01e-04194635955_UP
DrugST021200; Up 200; 10uM; PC3; HT_HG-U133A

FZD7 JCAD PPP2R5D MIA2 YLPM1

2.06e-041956357559_UP
DrugAC1L18R8

HOXA5 NUMBL TAF1 EP300

2.06e-04105634CID000050261
DrugLDN 193189

SMAD1 SMAD5

2.09e-048632ctd:C554430
DrugMethacholine chloride [62-51-1]; Down 200; 20.4uM; MCF7; HT_HG-U133A

FOXJ2 ANXA11 TDP1 ZNF282 SMAD5

2.11e-041966356248_DN
DrugCotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A

SETD1B NF2 CNTRL RNF216 ARID1A

2.11e-041966351511_DN
DrugPivmecillinam hydrochloride [32887-03-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A

SOX3 COL8A1 TAF1 BCL3 MBNL3

2.11e-041966356014_DN
DrugEsculin Hydrate [531-75-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

COL8A1 NF2 BCL3 ARID1A SMAD1

2.11e-041966353390_DN
DrugRibostamycin sulfate salt [53797-35-6]; Down 200; 7.2uM; PC3; HT_HG-U133A

JCAD NF2 YLPM1 RNF216 EP300

2.11e-041966357123_DN
DrugPilocarpine nitrate [148-72-1]; Down 200; 14.8uM; MCF7; HT_HG-U133A

FZD7 PPP2R5D PER3 ANXA11 SMAD5

2.16e-041976355341_DN
DrugEthoxyquin [91-53-2]; Down 200; 18.4uM; HL60; HT_HG-U133A

HIVEP3 MIA2 NF2 ATXN1 R3HDM1

2.16e-041976352559_DN
DrugSuccinylsulfathiazole [116-43-8]; Down 200; 11.2uM; PC3; HT_HG-U133A

MIA2 NF2 CNTRL TAF1 PATJ

2.16e-041976354265_DN
DrugDimethadione [695-53-4]; Down 200; 31uM; MCF7; HT_HG-U133A

FZD7 COL8A1 CNTRL TAF1 PATJ

2.16e-041976355668_DN
DrugBudesonide [51333-22-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

COL8A1 PER3 NF2 YLPM1 TAF1

2.21e-041986355431_DN
DrugSparteine (-) [90-39-1]; Down 200; 17uM; PC3; HT_HG-U133A

FOXJ2 COL8A1 SETD1B NF2 PATJ

2.21e-041986354568_DN
DrugTriprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A

FZD7 PER3 NF2 CNTRL SMAD1

2.21e-041986357008_UP
Drugsulindac; Up 200; 100uM; MCF7; HG-U133A

HOXA5 MLXIPL WASL MIA2 NDUFB7

2.21e-04198635168_UP
DrugBenzonatate [104-31-4]; Up 200; 6.6uM; MCF7; HT_HG-U133A

FOXJ2 HIVEP3 COL8A1 PATJ SMAD5

2.26e-041996351679_UP
DrugNitrocaramiphen hydrochloride; Down 200; 10.8uM; HL60; HT_HG-U133A

HOXA5 HIVEP3 COL8A1 NF2 SMAD1

2.26e-041996353125_DN
DrugAscorbic acid [50-81-7]; Down 200; 22.4uM; MCF7; HT_HG-U133A

MIA2 NF2 PATJ ZNF282 MBNL3

2.26e-041996355407_DN
DrugCefoxitin sodium salt [33564-30-6]; Down 200; 8.8uM; MCF7; HT_HG-U133A

FZD7 CNTRL YLPM1 RNF216 MBNL3

2.31e-042006353477_DN
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

HIVEP3 SMAD1 SMAD5

2.37e-0613613DOID:0050787 (implicated_via_orthology)
DiseaseMENTAL RETARDATION, AUTOSOMAL DOMINANT 12

SMARCE1 ARID1A

4.19e-055612C3281201
Diseasemeningioma (is_implicated_in)

NF2 SMARCE1

6.27e-056612DOID:3565 (is_implicated_in)
DiseaseFamilial meningioma

NF2 SMARCE1

6.27e-056612C1333989
Diseasefamilial meningioma (is_implicated_in)

NF2 SMARCE1

6.27e-056612DOID:4586 (is_implicated_in)
DiseaseMENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO

NF2 SMARCE1

6.27e-056612607174
DiseaseFamilial meningioma

NF2 SMARCE1

6.27e-056612cv:C3551915
Diseasecholesteryl esters to total lipids in IDL percentage

MLXIPL BCL3 ARID1A

1.54e-0450613EFO_0022247
DiseaseWithdrawal Symptoms

PER3 SMAD1 SMAD5

2.39e-0458613C0087169
DiseaseDrug Withdrawal Symptoms

PER3 SMAD1 SMAD5

2.39e-0458613C0086189
DiseaseSubstance Withdrawal Syndrome

PER3 SMAD1 SMAD5

2.39e-0458613C0038587
DiseaseCoffin-Siris syndrome

SMARCE1 ARID1A

3.23e-0413612C0265338
DiseaseT-Cell Lymphoma

ARID1A EP300

4.95e-0416612C0079772
Diseasenervousness

YLPM1 DENND1A

4.95e-0416612NCIT_C74532
Diseasemyeloid white cell count

HIVEP3 PPP1R8 JCAD MLXIPL SETD1B BPI ATXN1 ZNF282

6.66e-04937618EFO_0007988
DiseaseMeningioma

NF2 SMARCE1

7.03e-0419612C0025286
Diseaseeosinophil percentage of leukocytes

TRERF1 HIVEP3 MLXIPL SMARCE1 BCL3 ZNF282 HNRNPC

8.56e-04746617EFO_0007991
DiseaseAdenocarcinoma of large intestine

TAF1 DCC EP300

1.05e-0396613C1319315
DiseaseAdenoid Cystic Carcinoma

SMARCE1 ARID1A EP300

1.18e-03100613C0010606
DiseaseKallmann Syndrome

SOX3 DCC

1.32e-0326612C0162809
Diseasefamilial hyperlipidemia

MLXIPL BCL3 ARID1A

1.39e-03106613MONDO_0001336
DiseaseColorectal cancer

DCC EP300

1.43e-0327612cv:C0346629
DiseaseCOLORECTAL CANCER

DCC EP300

1.43e-0327612114500
DiseaseNeoplasm of the large intestine

DCC EP300

1.43e-0327612cv:C0009404
Diseasemonocyte count

PCED1A HIVEP3 JCAD MLXIPL ZBTB7C BPI ATXN1 YLPM1 RNF216

1.49e-031320619EFO_0005091
DiseaseBilateral Wilms Tumor

DROSHA ARID1A

1.65e-0329612C2930471
Diseaseobsolete_red blood cell distribution width

MLXIPL SETD1B SHISA5 MAPK1IP1L YLPM1 R3HDM1 MIDEAS EP300 SMAD1

1.71e-031347619EFO_0005192
Diseasecolorectal cancer (is_implicated_in)

NF2 DCC EP300

2.04e-03121613DOID:9256 (is_implicated_in)
Diseaseneutrophil count

TRERF1 FOXJ2 HIVEP3 JCAD MLXIPL ATXN1 R3HDM1 ARID1A ZNF282

2.04e-031382619EFO_0004833

Protein segments in the cluster

PeptideGeneStartEntry
QPTPPNSMPPYLPRT

EP300

1876

Q09472
VPQGMALYAPPPPLP

CNTRL

1256

Q7Z7A1
PMVYGPPPPNFSIPF

CNTRL

1291

Q7Z7A1
PPPPNFSIPFIPMGV

CNTRL

1296

Q7Z7A1
AAYPPPPSMPPIGLD

ANXA11

26

P50995
NPQYPMFRAPPPLPP

PPP2R5D

516

Q14738
ASPAAAPPTLPPYFM

ATXN1

561

P54253
VFQPPLPPDSPRYCM

C3orf70

111

A6NLC5
LVPYVPPPLLPSMFY

DEXI

16

O95424
MPPALQPFPAPVGPF

NUMBL

456

Q9Y6R0
PYMYPALPPAAPGPL

MSANTD5

191

A0A3B3IT52
SGYIMTAAPPPHPPP

R3HDM1

581

Q15032
RQPPYGPSAPVPPMT

ARID1A

1551

O14497
PPPMSAIEPKVPYTP

DCC

1351

P43146
DGMYSFPARVPPPPP

HNRNPCL1

121

O60812
MYSYPARVPPPPPIA

HNRNPC

136

P07910
DGMYSFPARVPPPPP

HNRNPCL2

121

B2RXH8
PKMPPYPPTCAPNLD

JCAD

256

Q9P266
PPAAMVPSQAPYLVP

PER3

786

P56645
SSLPPPMPFPYPLPQ

PCED1A

316

Q9H1Q7
PSPAPPAQPQIYPWM

HOXA5

166

P20719
VPPPPMEPDHPFYSN

PGAM4

121

Q8N0Y7
APHLYPGPSPMYPIP

FOXJ2

521

Q9P0K8
AMPSPDVVYGALPPP

MEF2B

136

Q02080
EPDPLQMPTFPPDYG

NDUFB7

16

P17568
ATKPTYPPMNPIPAP

NF2

476

P35240
PPMVPRQASFFPPPV

LPCAT2

26

Q7L5N7
YAVPCPPGHFPPMSP

FZD7

511

O75084
PPLGPFPVLYSPAMP

E2F7

751

Q96AV8
NPPPFAPPVMEFPAA

BPI

266

P17213
PAVMPPTPPPQGEYL

COL8A1

571

P27658
PSIPANPPMAFNPYI

MBNL3

121

Q9NUK0
MAPYPFPPNPDMNPE

MIDEAS

306

Q6PJG2
FPQPPLNPFVPSMPA

DENND1A

826

Q8TEH3
PPGFPMAPPNFFLPS

BCL3

411

P20749
MAPPNFFLPSPSPPA

BCL3

416

P20749
VPPPPMEPDHPFYSN

PGAM1

121

P18669
GMPATVYPAPIPPPR

FAM168B

126

A1KXE4
PPPAPFAMRNVYPPR

MIA2

1351

Q96PC5
YPTPNMPFPELPRPY

MAPK1IP1L

116

Q8NDC0
PDFVPFPPPMPPSAQ

DROSHA

76

Q9NRR4
YAQPPSMSSPPPPPA

SOX3

281

P41225
PMPYPNLAPDVDLTP

PPP1R8

291

Q12972
MSKRPSYAPPPTPAP

SMARCE1

1

Q969G3
SYAPPPTPAPATQMP

SMARCE1

6

Q969G3
PMTPGPYTPQPPDLY

TAF1

1636

P21675
APYLMFPPPPFGLPI

SHOX

236

O15266
MPAAPYPMQYPPPYP

SHISA5

186

Q8N114
PLPKFDPSVPPPGYM

SETD1B

836

Q9UPS6
QMPPYAFAHPPFPLP

RNF216

796

Q9NWF9
LNMGPIPAPYVPPLP

RNF216

821

Q9NWF9
PPMPSNFPEPPSFSP

MLXIPL

311

Q9NP71
QLPADTPPPAYMPPD

SMAD5

216

Q99717
FQMPADTPPPAYLPP

SMAD1

216

Q15797
DTPPPAYLPPEDPMT

SMAD1

221

Q15797
YPTPPPYPFTPFMTV

C11orf53

176

Q8IXP5
PMATFPVPYDLPPEL

TDP1

566

Q9NUW8
PTPYNPPLAGAPMPL

SOX15

216

O60248
MAPPAYSLYTPEPPP

TMEM52

141

Q8NDY8
RQGTAPPPMKLPPPY

PATJ

1191

Q8NI35
YSMPPLPPSLFQAPP

HIVEP3

1176

Q5T1R4
PFRQPPSFLPMPYPT

HIVEP3

1216

Q5T1R4
YPAQVTAMPPETPLP

IGSF9

321

Q9P2J2
PMPPPPGPALSYQKQ

YLPM1

106

P49750
SYMPPSQSYMPPPQP

YLPM1

156

P49750
PPPPFPNDFFKDMFP

ZBTB7C

301

A1YPR0
NPYFWPPPPTMPSQL

ZNF362

21

Q5T0B9
SAPMPFPLPVVPDYS

USP30

416

Q70CQ3
RMYPPPPPALPSSAP

WASL

341

O00401
EEQPQPPLAMPPYPL

VPS37C

191

A5D8V6
PPLAMPPYPLPYSPS

VPS37C

196

A5D8V6
PMPFQFPPFPDRAPV

ZNF282

66

Q9UDV7
LFIPPPPSYNPNPAA

TRERF1

661

Q96PN7
NPIMPQYPFPLPVFD

NAF1

416

Q96HR8