Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.44e-06	5	106	3	GO:0030156
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	2.79e-05	2	106	2	GO:0140981
GeneOntologyMolecularFunction	forked DNA-dependent helicase activity	WRN BLM	2.79e-05	2	106	2	GO:0061749
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	2.79e-05	2	106	2	GO:0103002
GeneOntologyMolecularFunction	8-hydroxy-2'-deoxyguanosine DNA binding	WRN BLM	8.35e-05	3	106	2	GO:1905773
GeneOntologyMolecularFunction	telomeric G-quadruplex DNA binding	WRN BLM	8.35e-05	3	106	2	GO:0061849
GeneOntologyMolecularFunction	Y-form DNA binding	WRN BLM	1.66e-04	4	106	2	GO:0000403
GeneOntologyMolecularFunction	telomeric D-loop binding	WRN BLM	1.66e-04	4	106	2	GO:0061821
GeneOntologyMolecularFunction	D-loop DNA binding	WRN BLM	4.13e-04	6	106	2	GO:0062037
GeneOntologyMolecularFunction	four-way junction helicase activity	WRN BLM	4.13e-04	6	106	2	GO:0009378
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	5.76e-04	7	106	2	GO:0050051
GeneOntologyMolecularFunction	MutLalpha complex binding	WRN PCNA	5.76e-04	7	106	2	GO:0032405
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	5.76e-04	7	106	2	GO:0018685
GeneOntologyMolecularFunction	bubble DNA binding	WRN BLM	7.66e-04	8	106	2	GO:0000405
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	1.22e-03	10	106	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.22e-03	10	106	2	GO:0120250
GeneOntologyMolecularFunction	oxidized purine DNA binding	WRN BLM	1.22e-03	10	106	2	GO:0032357
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.22e-03	10	106	2	GO:0102033
GeneOntologyMolecularFunction	mismatch repair complex binding	WRN PCNA	1.49e-03	11	106	2	GO:0032404
GeneOntologyMolecularFunction	oxidized DNA binding	WRN BLM	1.49e-03	11	106	2	GO:0032356
GeneOntologyMolecularFunction	phosphatidylinositol binding	MYO1G ATG2B OBSCN SYT10 PASK ZFYVE26 ARHGAP33	1.49e-03	316	106	7	GO:0035091
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4A11 CYP4A22	2.10e-03	13	106	2	GO:0016713
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	ATG2B OBSCN ZFYVE26	2.11e-03	48	106	3	GO:0032266
GeneOntologyMolecularFunction	amyloid-beta binding	HSPG2 INSR APBA3 MAPK8IP2	2.14e-03	102	106	4	GO:0001540
GeneOntologyMolecularFunction	G-quadruplex DNA binding	WRN BLM	2.44e-03	14	106	2	GO:0051880
GeneOntologyMolecularFunction	peptidase activity	ADAMTS19 PRSS41 LONP2 KLK12 TMPRSS12 ERMP1 ADAM12 ADAM22 UNC5CL OTUD3	2.51e-03	654	106	10	GO:0008233
GeneOntologyMolecularFunction	arachidonate binding	CYP4A11 CYP4A22	2.80e-03	15	106	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4A11 CYP4A22	3.19e-03	16	106	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4A11 CYP4A22	3.19e-03	16	106	2	GO:0050543
GeneOntologyMolecularFunction	3'-5' DNA helicase activity	WRN BLM	3.19e-03	16	106	2	GO:0043138
GeneOntologyBiologicalProcess	telomere maintenance via semi-conservative replication	WRN BLM PCNA	9.94e-06	9	103	3	GO:0032201
Domain	SH3	OBSCN RIMBP3 GRAP2 RIMBP3C MYO15A RIMBP3B ARHGAP33 MAPK8IP2	2.61e-05	216	103	8	SM00326
Domain	SH3	OBSCN RIMBP3 GRAP2 RIMBP3C MYO15A RIMBP3B ARHGAP33 MAPK8IP2	2.61e-05	216	103	8	PS50002
Domain	SH3_domain	OBSCN RIMBP3 GRAP2 RIMBP3C MYO15A RIMBP3B ARHGAP33 MAPK8IP2	2.97e-05	220	103	8	IPR001452
Domain	RQC	WRN BLM	3.01e-05	2	103	2	SM00956
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B ARHGAP33 MAPK8IP2	7.10e-05	78	103	5	PF14604
Domain	-	WRN BLM	9.00e-05	3	103	2	1.10.150.80
Domain	HRDC	WRN BLM	9.00e-05	3	103	2	SM00341
Domain	RQC_domain	WRN BLM	9.00e-05	3	103	2	IPR018982
Domain	HRDC	WRN BLM	9.00e-05	3	103	2	PS50967
Domain	RQC	WRN BLM	9.00e-05	3	103	2	PF09382
Domain	HRDC	WRN BLM	9.00e-05	3	103	2	PF00570
Domain	SH3_2	RIMBP3 RIMBP3C MYO15A RIMBP3B ARHGAP33	1.13e-04	86	103	5	PF07653
Domain	SH3_2	RIMBP3 RIMBP3C MYO15A RIMBP3B ARHGAP33	1.13e-04	86	103	5	IPR011511
Domain	FN3	ROBO4 LRIT2 INSR OBSCN RIMBP3 RIMBP3C RIMBP3B	1.17e-04	199	103	7	PS50853
Domain	FN3_dom	ROBO4 LRIT2 INSR OBSCN RIMBP3 RIMBP3C RIMBP3B	1.59e-04	209	103	7	IPR003961
Domain	HRDC_dom	WRN BLM	1.79e-04	4	103	2	IPR002121
Domain	RecQ_Zn_bind	WRN BLM	1.79e-04	4	103	2	PF16124
Domain	RecQ_Zn-bd	WRN BLM	1.79e-04	4	103	2	IPR032284
Domain	Ank_2	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	1.89e-04	215	103	7	PF12796
Domain	P-loop_NTPase	MYO1G LONP2 DYNC2H1 KIF26B DHX38 WRN NLRC4 BLM NLRP10 NOD1 ASPM GTPBP3 MYO15A AGAP1	2.28e-04	848	103	14	IPR027417
Domain	NACHT	NLRC4 NLRP10 NOD1	2.66e-04	23	103	3	PS50837
Domain	NACHT_NTPase	NLRC4 NLRP10 NOD1	2.66e-04	23	103	3	IPR007111
Domain	-	A1BG ROBO4 HSPG2 LRIT2 INSR OBSCN TRIM3 RIMBP3 ICAM5 FCRLB RIMBP3C RIMBP3B	2.90e-04	663	103	12	2.60.40.10
Domain	HRDC-like	WRN BLM	2.98e-04	5	103	2	IPR010997
Domain	DNA_helicase_ATP-dep_RecQ	WRN BLM	2.98e-04	5	103	2	IPR004589
Domain	ADAM_Cys-rich	ADAMTS19 ADAM12 ADAM22	4.33e-04	27	103	3	IPR006586
Domain	ACR	ADAMTS19 ADAM12 ADAM22	4.33e-04	27	103	3	SM00608
Domain	-	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	4.49e-04	248	103	7	1.25.40.20
Domain	EGF-like_dom	TPO HSPG2 ADAM12 ADAM22 ITGBL1 NRXN2 SUSD1	4.60e-04	249	103	7	IPR000742
Domain	ANK	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	4.82e-04	251	103	7	SM00248
Domain	ANK_REPEAT	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	5.06e-04	253	103	7	PS50088
Domain	Ig-like_fold	A1BG ROBO4 HSPG2 LRIT2 INSR OBSCN TRIM3 RIMBP3 ICAM5 FCRLB RIMBP3C RIMBP3B	5.10e-04	706	103	12	IPR013783
Domain	Ankyrin_rpt-contain_dom	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	5.18e-04	254	103	7	IPR020683
Domain	ANK_REP_REGION	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	5.18e-04	254	103	7	PS50297
Domain	EGF_1	TPO HSPG2 ADAM12 ADAM22 ITGBL1 NRXN2 SUSD1	5.30e-04	255	103	7	PS00022
Domain	FN3	ROBO4 LRIT2 INSR OBSCN RIMBP3C RIMBP3B	5.62e-04	185	103	6	SM00060
Domain	Ankyrin_rpt	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	6.22e-04	262	103	7	IPR002110
Domain	EGF_2	TPO HSPG2 ADAM12 ADAM22 ITGBL1 NRXN2 SUSD1	6.65e-04	265	103	7	PS01186
Domain	Ig_2	A1BG HSPG2 ICAM5 FCRLB	7.09e-04	73	103	4	PF13895
Domain	PID	APBA3 RGS12 MAPK8IP2	7.19e-04	32	103	3	PS01179
Domain	Ribosomal_S5_D2-typ_fold	LONP2 IMPACT EXOSC7	8.61e-04	34	103	3	IPR020568
Domain	DEAH_ATP_HELICASE	DHX38 WRN BLM	1.19e-03	38	103	3	PS00690
Domain	Pep_M12B_propep	ADAMTS19 ADAM12 ADAM22	1.29e-03	39	103	3	PF01562
Domain	Peptidase_M12B_N	ADAMTS19 ADAM12 ADAM22	1.29e-03	39	103	3	IPR002870
Domain	PTB	APBA3 RGS12 MAPK8IP2	1.39e-03	40	103	3	SM00462
Domain	DISINTEGRIN_1	ADAMTS19 ADAM12 ADAM22	1.39e-03	40	103	3	PS00427
Domain	Reprolysin	ADAMTS19 ADAM12 ADAM22	1.39e-03	40	103	3	PF01421
Domain	ADAM_MEPRO	ADAMTS19 ADAM12 ADAM22	1.39e-03	40	103	3	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAM12 ADAM22	1.39e-03	40	103	3	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAM12 ADAM22	1.39e-03	40	103	3	IPR001590
Domain	PTB/PI_dom	APBA3 RGS12 MAPK8IP2	1.49e-03	41	103	3	IPR006020
Domain	Disintegrin_dom	ADAMTS19 ADAM12 ADAM22	1.49e-03	41	103	3	IPR001762
Domain	Ank	ANKK1 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	1.66e-03	228	103	6	PF00023
Domain	-	NLRC4 NLRP10 NOD1 UNC5CL	1.75e-03	93	103	4	1.10.533.10
Domain	EGF	TPO HSPG2 ADAM22 ITGBL1 NRXN2 SUSD1	1.93e-03	235	103	6	SM00181
Domain	IGc2	A1BG ROBO4 HSPG2 LRIT2 OBSCN ICAM5	1.93e-03	235	103	6	SM00408
Domain	EGF_3	TPO HSPG2 ADAM12 ADAM22 NRXN2 SUSD1	1.93e-03	235	103	6	PS50026
Domain	Ig_sub2	A1BG ROBO4 HSPG2 LRIT2 OBSCN ICAM5	1.93e-03	235	103	6	IPR003598
Domain	DEATH-like_dom	NLRC4 NLRP10 NOD1 UNC5CL	2.20e-03	99	103	4	IPR011029
Domain	-	LONP2 DYNC2H1 DHX38 WRN NLRC4 BLM NLRP10 NOD1 GTPBP3 MYO15A AGAP1	2.71e-03	746	103	11	3.40.50.300
Domain	EGF-like_CS	TPO HSPG2 ADAM12 ADAM22 NRXN2 SUSD1	3.25e-03	261	103	6	IPR013032
Domain	Disintegrin_CS	ADAM12 ADAM22	3.44e-03	16	103	2	IPR018358
Domain	Ig_I-set	ROBO4 HSPG2 LRIT2 OBSCN ICAM5	4.05e-03	190	103	5	IPR013098
Domain	I-set	ROBO4 HSPG2 LRIT2 OBSCN ICAM5	4.05e-03	190	103	5	PF07679
Domain	ADAM_CR	ADAM12 ADAM22	4.35e-03	18	103	2	PF08516
Domain	EGF_extracell	ADAM12 ADAM22 ITGBL1	4.44e-03	60	103	3	IPR013111
Domain	EGF_2	ADAM12 ADAM22 ITGBL1	4.44e-03	60	103	3	PF07974
Domain	-	ADAM12 ADAM22	5.36e-03	20	103	2	4.10.70.10
Pathway	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_C_STRAND_OF_THE_TELOMERE	WRN BLM PCNA	6.94e-05	18	64	3	MM14682
Pathway	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_C_STRAND_OF_THE_TELOMERE	WRN BLM PCNA	8.21e-05	19	64	3	M27029
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.16e-07	4	108	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	2.90e-07	5	108	3	17855024
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF536 IL16 BCL11A ZZEF1 SIRT5 PASK ZNF469 ZNF24 GRAP2 ASPM NUP188 PRDM16 ANKRD52 UNC80 ARHGAP33	1.93e-06	1116	108	15	31753913
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SZT2 SPG11 ERMP1 ZZEF1 NACAD PASK NRXN2 NUP188 EXOSC7 AGAP1	6.22e-06	529	108	10	14621295
Pubmed	Hereditary spastic paraplegia with mental impairment and thin corpus callosum in Tunisia: SPG11, SPG15, and further genetic heterogeneity.	SPG11 ZFYVE26	9.55e-06	2	108	2	18332254
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	9.55e-06	2	108	2	15611369
Pubmed	Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.	WRN BLM	9.55e-06	2	108	2	23253856
Pubmed	The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.	WRN BLM	9.55e-06	2	108	2	21736299
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	9.55e-06	2	108	2	23825080
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	9.55e-06	2	108	2	16691295
Pubmed	Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.	WRN BLM	9.55e-06	2	108	2	15367665
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	9.55e-06	2	108	2	3829886
Pubmed	The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.	WRN BLM	9.55e-06	2	108	2	17115688
Pubmed	Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.	WRN BLM	9.55e-06	2	108	2	11735402
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	9.55e-06	2	108	2	29277328
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	9.55e-06	2	108	2	21820496
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	9.55e-06	2	108	2	23641057
Pubmed	Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.	WRN BLM	9.55e-06	2	108	2	11919194
Pubmed	Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.	WRN BLM	9.55e-06	2	108	2	16412221
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	9.55e-06	2	108	2	20943934
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	9.55e-06	2	108	2	28912346
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	9.55e-06	2	108	2	24413902
Pubmed	The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres.	WRN BLM	9.55e-06	2	108	2	22989712
Pubmed	Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis.	WRN BLM	9.55e-06	2	108	2	18028256
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	9.55e-06	2	108	2	2766933
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	9.55e-06	2	108	2	8031839
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	9.55e-06	2	108	2	10860550
Pubmed	The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.	WRN BLM	9.55e-06	2	108	2	22272300
Pubmed	Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.	WRN PCNA	9.55e-06	2	108	2	12633936
Pubmed	Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.	WRN BLM	9.55e-06	2	108	2	10871376
Pubmed	Characterization of the human and mouse WRN 3'-->5' exonuclease.	WRN PCNA	9.55e-06	2	108	2	10871373
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	9.55e-06	2	108	2	17112342
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	9.55e-06	2	108	2	11320253
Pubmed	ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis.	SPG11 ZFYVE26	9.55e-06	2	108	2	30081747
Pubmed	The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.	WRN BLM	9.55e-06	2	108	2	11433031
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	9.55e-06	2	108	2	12464262
Pubmed	BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.	WRN BLM	9.55e-06	2	108	2	26195664
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	9.55e-06	2	108	2	30088983
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	9.55e-06	2	108	2	15066132
Pubmed	Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.	WRN BLM	9.55e-06	2	108	2	27238185
Pubmed	RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange.	WRN BLM	9.55e-06	2	108	2	15845538
Pubmed	Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia.	SPG11 ZFYVE26	9.55e-06	2	108	2	19917823
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	9.55e-06	2	108	2	19208908
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.03e-05	14	108	3	17662146
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SPG11 ERMP1 BCL11A ZNF469 UNC80	2.17e-05	107	108	5	11347906
Pubmed	Nuclear structure in normal and Bloom syndrome cells.	WRN BLM	2.86e-05	3	108	2	10779560
Pubmed	Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.	SPG11 ZFYVE26	2.86e-05	3	108	2	33618608
Pubmed	Delineation of WRN helicase function with EXO1 in the replicational stress response.	WRN BLM	2.86e-05	3	108	2	20447876
Pubmed	Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.	WRN BLM	2.86e-05	3	108	2	14688284
Pubmed	Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.	SPG11 ZFYVE26	2.86e-05	3	108	2	21545838
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	2.86e-05	3	108	2	2354437
Pubmed	Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.	SPG11 ZFYVE26	2.86e-05	3	108	2	23825025
Pubmed	Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.	SPG11 ZFYVE26	2.86e-05	3	108	2	25365221
Pubmed	Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases.	WRN BLM	2.86e-05	3	108	2	27407146
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	2.86e-05	3	108	2	8011168
Pubmed	Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.	WRN BLM	2.86e-05	3	108	2	17961633
Pubmed	Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1.	WRN BLM	2.86e-05	3	108	2	19734539
Pubmed	Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.	WRN BLM	2.86e-05	3	108	2	27612385
Pubmed	The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.	WRN BLM	2.86e-05	3	108	2	12080066
Pubmed	HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN.	WRN BLM	2.86e-05	3	108	2	33432007
Pubmed	Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.	WRN BLM	2.86e-05	3	108	2	19945966
Pubmed	POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.	WRN BLM	2.86e-05	3	108	2	16030011
Pubmed	A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.	WRN BLM	2.86e-05	3	108	2	19205873
Pubmed	DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.	WRN BLM	2.86e-05	3	108	2	25122754
Pubmed	DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.	WRN BLM	2.86e-05	3	108	2	25921537
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	2.86e-05	3	108	2	28270609
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	2.86e-05	3	108	2	1991046
Pubmed	Fibroblast growth factor homologous factors are intracellular signaling proteins.	FGF12 MAPK8IP2	2.86e-05	3	108	2	11378392
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	2.86e-05	3	108	2	19713718
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	2.86e-05	3	108	2	15313227
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	2.86e-05	3	108	2	37659685
Pubmed	Functional interaction of p53 and BLM DNA helicase in apoptosis.	WRN BLM	2.86e-05	3	108	2	11399766
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	2.86e-05	3	108	2	9271096
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 SETD1B SZT2 GRK6 OBSCN PFAS ZZEF1 RYR1 SAC3D1 ZFYVE26 NUP188 PRDM16 ARHGAP33	3.96e-05	1105	108	13	35748872
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	5.71e-05	4	108	2	8334987
Pubmed	An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.	BCL11A PRDM16	5.71e-05	4	108	2	25330008
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 CYP4A22	5.71e-05	4	108	2	1552159
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	5.71e-05	4	108	2	10049703
Pubmed	The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu Eye Study.	WRN BLM	5.71e-05	4	108	2	23322570
Pubmed	Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.	NLRC4 NOD1	5.71e-05	4	108	2	16648853
Pubmed	WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.	WRN PCNA	5.71e-05	4	108	2	14657243
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	DYNC2H1 OBSCN	5.71e-05	4	108	2	26147384
Pubmed	Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.	WRN BLM	5.71e-05	4	108	2	12181313
Pubmed	The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.	WRN BLM	5.71e-05	4	108	2	16326861
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	5.71e-05	4	108	2	22159897
Pubmed	WRN participates in translesion synthesis pathway through interaction with NBS1.	WRN PCNA	5.71e-05	4	108	2	20600238
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	5.71e-05	4	108	2	21161333
Pubmed	Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.	NLRC4 NLRP10	9.50e-05	5	108	2	23071280
Pubmed	RecQ helicase expression in patients with telomeropathies.	WRN BLM	9.50e-05	5	108	2	38874681
Pubmed	RecQ helicases: suppressors of tumorigenesis and premature aging.	WRN BLM	9.50e-05	5	108	2	12803543
Pubmed	Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.	CYP4A11 CYP4A22	9.50e-05	5	108	2	8363569
Pubmed	WRN interacts physically and functionally with the recombination mediator protein RAD52.	WRN PCNA	9.50e-05	5	108	2	12750383
Pubmed	PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.	IL16 PPP1R12C	9.50e-05	5	108	2	12923170
Pubmed	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	SPG11 ZFYVE26	9.50e-05	5	108	2	20613862
Pubmed	Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.	RYR1 PRDM16	9.50e-05	5	108	2	11818962
Pubmed	Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.	WRN BLM	9.50e-05	5	108	2	15965237
Pubmed	Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	9.50e-05	5	108	2	20427718
Pubmed	Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene.	KRT85 PCNA	9.50e-05	5	108	2	11296228
Pubmed	Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.	CYP4A11 CYP4A22	9.50e-05	5	108	2	7601480
Pubmed	Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.	WRN BLM	9.50e-05	5	108	2	18978339
GeneFamily	Ankyrin repeat domain containing	ANKK1 ANKRD65 NFKBIB ABTB1 ANKRD52 PPP1R12C AGAP1	4.96e-05	242	72	7	403
GeneFamily	NLR family	NLRC4 NLRP10 NOD1	1.31e-04	25	72	3	666
GeneFamily	RecQ like helicases	WRN BLM	1.55e-04	5	72	2	1049
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ROBO4 HSPG2 LRIT2 OBSCN	3.90e-03	161	72	4	593
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM12 ADAM22	5.15e-03	27	72	2	47
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	NLRC4 NOD1	6.33e-03	30	72	2	959
GeneFamily	Immunoglobulin like domain containing	A1BG HSPG2 ICAM5 FCRLB	7.36e-03	193	72	4	594
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B PRDM16	8.08e-03	34	72	2	487
GeneFamily	Cytochrome P450 family 4	CYP4A11 CYP4A22	9.03e-03	36	72	2	1003
Coexpression	GSE2405_S_AUREUS_VS_A_PHAGOCYTOPHILUM_NEUTROPHIL_DN	SZT2 GRK6 ATG2B WRN APBA3 ZZEF1 RGS12 ZFYVE26 NUP188	1.62e-07	200	109	9	M6208
Coexpression	GSE23321_CD8_STEM_CELL_MEMORY_VS_NAIVE_CD8_TCELL_DN	SPG11 ERMP1 ZZEF1 PASK ABTB1 SAC3D1 ZFYVE26	1.84e-05	196	109	7	M8441
Coexpression	GSE37534_UNTREATED_VS_ROSIGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP	KIF26B INSR IMPACT ZZEF1 SIRT5 SAC3D1 OTUD3	1.90e-05	197	109	7	M8983
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDR1 IL16 ADAM12 NRXN2 PDXP UNC80 MAPK8IP2	4.94e-07	193	109	7	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF26B INSR KLK12 ADAM12 MYO15A PPP1R12C	3.65e-06	168	109	6	de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 DCBLD1 BLM GRAP2 BFSP2 ARHGAP33	4.32e-06	173	109	6	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 DCBLD1 BLM GRAP2 BFSP2 ARHGAP33	4.32e-06	173	109	6	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	severe_influenza-Plasmablast\|World / disease group, cell group and cell class (v2)	HSPG2 ASPM FGF12 SPACA3 PCNA SHISA3	4.62e-06	175	109	6	e6d6c44510d5dc4eb0bae820125e42366f7a4e74
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDR1 IL16 ADAM12 NRXN2 PDXP UNC80	6.55e-06	186	109	6	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 KRT85 ADAM12 PLEKHB1 LDHD UNC80	6.96e-06	188	109	6	8385fd384fc55e3b17802bb6698eb93b2c16d7f2
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 KRT85 ADAM12 PLEKHB1 LDHD UNC80	6.96e-06	188	109	6	cb9d0b48e2fd9cc576132803273b9c0382900944
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DYNC2H1 KIF26B FHOD3 ADAM22 SUSD1 PRDM16	7.18e-06	189	109	6	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDR1 ADAM12 NRXN2 PDXP UNC80 MAPK8IP2	7.18e-06	189	109	6	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DYNC2H1 KIF26B FHOD3 ADAM22 SUSD1 PRDM16	7.40e-06	190	109	6	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ATG2B WRN GZF1 CLEC11A ASPM GTPBP3	7.40e-06	190	109	6	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLM PTX3 UNC5CL FGF12 ARHGAP33	7.61e-06	110	109	5	0b39f3c358715e6e7288d3e4a0f3e7c0e877333c
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATG2B WRN GZF1 CLEC11A ASPM GTPBP3	7.85e-06	192	109	6	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	INSR OBSCN FHOD3 EMC10 FGF12 PRDM16	8.09e-06	193	109	6	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO4 HSPG2 LINC02875 INSR DCBLD1 TRIM3	9.63e-06	199	109	6	d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO4 HSPG2 LINC02875 INSR DCBLD1 TRIM3	9.63e-06	199	109	6	cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TPO KIF26B SUSD1 BFSP2 PRDM16	3.09e-05	147	109	5	b66ccc710b3c04f6fc7fed69f3c892fc110e98fc
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADAM12 ZFPL1 BLM ASPM ANKRD52	3.19e-05	148	109	5	80470353e12599440f711b6e107730763376d04d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	INSR ADAM12 SYT10 NACAD CLEC11A	4.63e-05	160	109	5	778faada072e3abfa76a9a06fd4885fb63de7902
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS19 KIF26B PTX3 ICAM5 ANTKMT	4.91e-05	162	109	5	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN BCL11A NRXN2 BFSP2 ARHGAP33	5.68e-05	167	109	5	1248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN BCL11A NRXN2 BFSP2 ARHGAP33	5.68e-05	167	109	5	a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRK6 BCL11A BLM UNC5CL BFSP2	6.35e-05	171	109	5	a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRK6 BCL11A BLM UNC5CL BFSP2	6.35e-05	171	109	5	43d8fd9b9546e84a652564fe96b514b34b06262b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ADAM12 RGS12 RIMBP3 RIMBP3B	6.53e-05	172	109	5	35e961c88bfe79046533396912cedf00ca81db7b
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ADAM12 ZFPL1 BLM ASPM ANKRD52	6.71e-05	173	109	5	efb8072475000888efe088d00e870c56ffad4172
ToppCell	facs-Heart-RA-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL16 BCL11A GRAP2 BFSP2 ARHGAP33	6.71e-05	173	109	5	49030c2dd04b592655df1a667e2f90efb499e0a5
ToppCell	facs-Heart-RA-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL16 BCL11A GRAP2 BFSP2 ARHGAP33	6.71e-05	173	109	5	1cfbab6603f8baf8e238837bb72740c43a7dc0ec
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ADAM12 ZFPL1 BLM ASPM ANKRD52	6.89e-05	174	109	5	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	Healthy_Control-Myeloid-Mast\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	HSPG2 OBSCN ADAM12 SYT10 GRAP2	7.08e-05	175	109	5	ca187074adcc9b8bd0fa270e2ede1564c8e6c6cf
ToppCell	Healthy_Control-Myeloid-Mast-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	HSPG2 OBSCN ADAM12 SYT10 GRAP2	7.08e-05	175	109	5	eadbbcdf2aef4cee268bc70a7a2c4175d898953b
ToppCell	Influenza_Severe-Plasmablast\|Influenza_Severe / Disease group and Cell class	ANKRD65 HSPG2 BFSP2 SPACA3 SHISA3	7.08e-05	175	109	5	3f9b9793d3d1b7a9b97899272b6a0d37b05c11d1
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SZT2 PFAS RYR1 BLM PCNA	7.88e-05	179	109	5	9dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDR1 IL16 RYR1 PDXP UNC80	8.09e-05	180	109	5	6ac62bf1251978c8c12e715f7b73144fca619794
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF26B FHOD3 ADAM22 SUSD1 PRDM16	8.09e-05	180	109	5	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BLM ASPM SAC3D1 ARHGAP33 PCNA	8.30e-05	181	109	5	73b1b59810f60e3e39ca1d5073a5a0d4f5377e6e
ToppCell	facs-Aorta-Heart-3m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G IL16 BCL11A RYR1 FCRLB	8.52e-05	182	109	5	df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-SELL+_CD8_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL16 GRK6 PASK GRAP2 ANTKMT	8.97e-05	184	109	5	c80acd6a81a3633d72813a77223879d0be254f93
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKK1 CDR1 PKDCC SYT10 UNC5CL	8.97e-05	184	109	5	6b0c110d8930df99043c3b99cf4d873985126960
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKK1 CDR1 PKDCC SYT10 UNC5CL	8.97e-05	184	109	5	35928fc5f7bbf8c7b09181a2bd27e22dff42ec16
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 KRT85 ADAM12 PLEKHB1 LDHD	8.97e-05	184	109	5	a7399a72f065d68800e3e0b2031d9894e0cc0ba4
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KLK12 PLEKHB1 TMEM132D UNC80 MAPK8IP2	9.44e-05	186	109	5	c7983281a290201567b398e9ea6baddb96c692bb
ToppCell	3'_v3-blood-Myeloid_Dendritic-DC2\|blood / Manually curated celltypes from each tissue	ANKRD65 INSR BCL11A RGS12 SPACA3	9.68e-05	187	109	5	9f3db9f0e5de34aeabfe5984f675bc7a65435df7
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	OBSCN FHOD3 BCL11A FGF12 PRDM16	9.68e-05	187	109	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FHOD3 ADAM22 SUSD1 FGF12 PRDM16	9.68e-05	187	109	5	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 PKDCC TMEM132D ICAM5 PRDM16	9.93e-05	188	109	5	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	OBSCN FHOD3 BCL11A FGF12 PRDM16	9.93e-05	188	109	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	OBSCN FHOD3 BCL11A FGF12 PRDM16	1.02e-04	189	109	5	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KIF26B ADAM22 SUSD1 FGF12 PRDM16	1.02e-04	189	109	5	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDR1 PLEKHB1 ADAM22 NRXN2 FGF12	1.02e-04	189	109	5	fcc3713e8200d51074f709f3360fb36efb0a639f
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	A1BG OBSCN PASK CLEC11A GRAP2	1.12e-04	193	109	5	627d345baf1940218c61907305705298e473dbab
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ZNF536 KIF26B BLM ASPM PCNA	1.15e-04	194	109	5	590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell	3'-Pediatric_IBD-SmallIntestine-Neuronal-Glial_mature-Adult_Glia\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 TMEM74 PLEKHB1 SYT10 PRDM16	1.15e-04	194	109	5	d429bb5e422a07bd92f0dc48cd51528e8b7d9a72
ToppCell	3'-Pediatric_IBD-SmallIntestine-Neuronal\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 TMEM74 PLEKHB1 SYT10 PRDM16	1.15e-04	194	109	5	bffdf6db0bf3fb338e7bb0789ae7dcde1fce0094
ToppCell	3'-Pediatric_IBD-SmallIntestine-Neuronal-Glial_mature\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 TMEM74 PLEKHB1 SYT10 PRDM16	1.15e-04	194	109	5	408dfc7060095972a54ae37ae8105521df6fbbee
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	INSR OBSCN FHOD3 EMC10 FGF12	1.18e-04	195	109	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPO ROBO4 ANKRD65 HSPG2 INSR	1.21e-04	196	109	5	c5fe470f11ee4962bcfb30cddfd8c078af5b1222
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANKK1 ADAM12 ZNF469 FGF12 PRDM16	1.24e-04	197	109	5	1ffbbe44db0fd3ebd91ad16ab0b91153de5d7c6d
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF536 KLK12 FHOD3 SYT10 UNC80	1.27e-04	198	109	5	2591e08e3fbee86ac40f11becd8147d6d39fded6
ToppCell	lymphoid-T_cell-CD8+_Naive_T_cell\|lymphoid / Lineage, cell class and subclass	A1BG IL16 PASK GRAP2 ANTKMT	1.30e-04	199	109	5	22926327c93ede9f3408c99a0d56e373a33240ef
ToppCell	Sigmoid-T_cell-cycling_gd_T\|T_cell / Region, Cell class and subclass	ADAM12 NOD1 ASPM SAC3D1 ZFYVE26	1.33e-04	200	109	5	4e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCell	Sigmoid-(1)_T_cell-(18)_cycling_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	ADAM12 NOD1 ASPM ZFYVE26 ANKRD52	1.33e-04	200	109	5	6e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCell	Sigmoid-T_cell-cycling_gd_T\|Sigmoid / Region, Cell class and subclass	ADAM12 NOD1 ASPM ZFYVE26 ANKRD52	1.33e-04	200	109	5	9769185abae084ffac36420c749625e679b70ca8
Disease	Werner syndrome (implicated_via_orthology)	WRN BLM	1.18e-04	5	102	2	DOID:5688 (implicated_via_orthology)
Disease	X-14939 measurement	CYP4A11 CYP4A22	1.76e-04	6	102	2	EFO_0800747
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	6.38e-04	11	102	2	DOID:0110861 (biomarker_via_orthology)
Disease	creatinine measurement	KIF26B LINC02875 GRK6 WBP1L OBSCN RGS12 RYR1 NRXN2 APOL3 UNC80 SHISA3	6.60e-04	995	102	11	EFO_0004518
Disease	dodecanedioate measurement	CYP4A11 PGGT1B	7.64e-04	12	102	2	EFO_0021054
Disease	illegal drug consumption	WDR64 TMEM132D	9.00e-04	13	102	2	EFO_0005431
Disease	insulin metabolic clearance rate measurement, glucose homeostasis measurement	ZZEF1 PLEKHB1	1.05e-03	14	102	2	EFO_0006830, EFO_0006896
Disease	glycine measurement	GRK6 INSR ERMP1 UNC80	1.33e-03	137	102	4	EFO_0009767
Disease	Infiltrating duct carcinoma of female breast	ANKK1 GRK6	2.38e-03	21	102	2	C3165106
Disease	pyruvate measurement	ZNF536 BCL11A RGS12 ITGBL1 TMEM132D	2.42e-03	268	102	5	EFO_0010117
Disease	seminoma (is_marker_for)	INSR PCNA	2.61e-03	22	102	2	DOID:4440 (is_marker_for)
Disease	hematocrit	WBP1L DHX38 INSR PKDCC PFAS BCL11A SUSD1 EMC10 PRDM16 ANKRD52	2.64e-03	1011	102	10	EFO_0004348

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGHLARGLCVRERGE	CHRNA10	341	Q9GZZ6
EGDGRTALHLACRKG	AGAP1	766	Q9UPQ3
DGTARLLLDHGACVD	ANKK1	441	Q8NFD2
ALRQLDGELGHLCRG	GTPBP3	176	Q969Y2
VLQVHEGGGERHRCG	GZF1	396	Q9H116
RHDALDTRVRGDLGG	ADAM22	66	Q9P0K1
EAGRDDLLGLLHCEE	APBA3	106	O96018
RCREEIHSLLGDGAS	CYP4A11	346	Q02928
GRILCRGTHVYLGDD	ADAM12	611	O43184
GRTALHRGAVTGCED	ANKRD52	721	Q8NB46
LERDHGAVEDLGGCL	BFSP2	101	Q13515
EDLEAIGRCGFSGRH	CDR1	131	P51861
VLRGAAGHRGEFDAL	ERMP1	96	Q7Z2K6
RDFLSGEGDLSRHLG	ASPM	931	Q8IZT6
EGGAHSLKDVCDLRR	ATG2B	881	Q96BY7
DLGSGDGRIVLAAHR	ANTKMT	81	Q9BQD7
RCHLGRSGLRCEEGV	HSPG2	3911	P98160
GHLGRACQERDASGL	RIMBP3B	641	A6NNM3
GHLGRACQERDASGL	RIMBP3C	641	A6NJZ7
CDGLLGSLAREDHCG	ADAMTS19	766	Q8TE59
GAVLAGRDAVLRCEG	A1BG	411	P04217
DLGQGRRFRESCVGH	PASK	806	Q96RG2
LGGVCDQSDIRGHRR	LONP2	401	Q86WA8
FIRSLDHCGDLALEG	NLRC4	386	Q9NPP4
EGTSLRCGGVLIDHR	KLK12	41	Q9UKR0
LLEGEEHRLCEGVGS	KRT85	426	P78386
GRDAGGLEAREHLLH	LRIT2	451	A6NDA9
EVAGDILRHRGLADG	MYO15A	2246	Q9UKN7
DDDGGCSELSRHRVL	NLRP10	396	Q86W26
SGGRSRLHLIDLGSC	KIF26B	701	Q2KJY2
LRRCAGLGHDSEEDS	MAPK8IP2	526	Q13387
KRGHLAEAEGHRDTC	BCL11A	571	Q9H165
AGAGLCVAERRGHTA	NFKBIB	116	Q15653
SGEFARICRDLSHIG	PCNA	141	P12004
VHCARSDGGAVLALG	ICAM5	441	Q9UMF0
GDFVHCEESGRRVLV	TPO	751	P07202
SVAHLDGRLRCGDEI	IL16	391	Q14005
DALHRIGQVERGCDG	NRXN2	1081	Q9P2S2
GRDTLCSLGQVAHRG	NOD1	456	Q9Y239
REGHVEVAGCLLDRG	ANKRD65	311	E5RJM6
RSSHCQREEAGGRDG	INSR	1331	P06213
HGVQEDLRVDGRGCE	EXOSC7	16	Q15024
CEDDGETAAGGRLLH	IMPACT	236	Q9P2X3
CLFRALGDQLEGHSR	OTUD3	76	Q5T2D3
GREEACGHREIHALV	PRSS41	41	Q7RTY9
RDGDRHSLRQDGAVC	OBSCN	3401	Q5VST9
DGDRHSLRQDGARCE	OBSCN	3666	Q5VST9
GILRQRVFGCDLGEH	ARHGAP33	306	O14559
GCRDHDEFIINLIRG	DYNC2H1	2181	Q8NCM8
ESGRAGRDGEISHCL	BLM	976	P54132
RCREEIHGLLGDGAS	CYP4A22	346	Q5TCH4
LGRRALALHGTCTGE	LDHD	451	Q86WU2
EAGCRALNVSEHARG	LINC02875	96	Q86X59
VCSSGGGEHRGLDRR	FHOD3	346	Q2V2M9
RALANGIEEVHRGCT	APOL3	171	O95236
GGCRGHEVEDVDLEL	EMC10	166	Q5UCC4
EARGAALGGVVLRCD	FCRLB	206	Q6BAA4
RLQAEELGDGCGHLV	DCBLD1	31	Q8N8Z6
RLGCRGGSAREVKEH	GRK6	431	P43250
ERRGGSLDINDGHCG	GRAP2	231	O75791
DGLREARDLCQAHGL	SAC3D1	331	A6NKF1
GRCELARVLHDFGLD	SPACA3	91	Q8IXA5
SRCEEGFVTGGHVLR	RYR1	206	P21817
RRCEDLDGVVCGGHG	ITGBL1	366	O95965
AGRHDGRVERELTCL	PKD1L1	1901	Q8TDX9
EEIRETGGAESCHIR	PTX3	346	P26022
DGRSLCERHVLGVFS	FGF12	36	P61328
GSGEGERLDFLRDRH	PGGT1B	11	P53609
SLIREDGGPGTECRH	SZT2	1936	Q5T011
SGHDLGSCVREFGVR	PKDCC	171	Q504Y2
GVEDACRLLAEHGGG	PPP1R12C	271	Q9BZL4
HPGGERGDCVREDAR	TMEM132D	231	Q14C87
GHLGRACQERDASGL	RIMBP3	641	Q9UFD9
HTRRCAEDHEGGLLA	PRDM16	1171	Q9HAZ2
GGCTNDRRELEHPGI	SHISA3	76	A0PJX4
DDGIREHVTGCARSE	SETD1B	1736	Q9UPS6
EIGRAGRDGLQSSCH	WRN	851	Q14191
VGDRLETDILFGHRC	PDXP	236	Q96GD0
RGSHSLELRACELGN	ROBO4	661	Q8WZ75
GRLDIGVEHVSDCER	ABTB1	176	Q969K4
RAEREHGRLEGCLKG	CLEC11A	166	Q9Y240
RGFRALGDICGHVHE	PRY	131	O14603
LIGRLLDDGCVHEAS	SPG11	1881	Q96JI7
LRHCDDDGRTENGAL	ZNF24	186	P17028
GDAIGVRLNELCHGE	UNC80	1281	Q8N2C7
DILSGLCERHGINGA	RGS12	986	O14924
REGGRLHLCAETKDD	PLEKHB1	101	Q9UF11
IDECEVSGLCRHGGR	SUSD1	126	Q6UWL2
DRLLCSGHDVSDGGL	PFAS	901	O15067
LVFSAREVDHRGGCL	UNC5CL	101	Q8IV45
RDQRDGVCVLGLHLA	NUP188	1276	Q5SRE5
LRRRREGGAHAEDCG	TMPRSS12	51	Q86WS5
AHALRLREGQSRCDG	SCART1	431	Q4G0T1
GRGDRAHEEDAGVRC	SCART1	871	Q4G0T1
HRLEGTDLDCQVGGL	DHX38	11	Q92620
VCRTGLDAEGLGRDH	SYT10	466	Q6XYQ8
ERERCDGGLPGNTHL	ZNF469	2996	Q96JG9
EDGLHVGLDERRGSG	ZNF536	661	O15090
SDGCDTRIHGLRAVG	ZZEF1	366	O43149
GHLEGCGADLHKEIR	ZZEF1	1631	O43149
SARLGAHLDRCVIAG	TMEM74	221	Q96NL1
AGHRAIAECETRLGK	SIRT5	116	Q9NXA8
LHALDEAGAEVRCGG	TMEM271	331	A0A286YF58
EAGEQLSRDGFHRLC	WDR87	2536	Q6ZQQ6
HRTQGPGCDELLRDA	ZFYVE26	391	Q68DK2
GRHRRFTGDSGIEVC	WBP1L	241	Q9NX94
DTRDDDRTPGLHGDC	ZFPL1	216	O95159
LGVHRVMSRGEGDCD	TYW1B	156	Q6NUM6
GECRAGEHREHGTVL	TRIM3	136	O75382
DHLCRDDILLGDDGG	WDR64	221	B1ANS9
LAAHCQGEGRTLEVR	MYO1G	961	B0I1T2
CGPHGDARDSEAELR	NACAD	191	O15069