Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine binding

CHRNA5 CHRNB4

3.64e-0413442GO:0042166
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine phosphatase activity

PTPRB PTPRH

6.32e-0417442GO:0005001
GeneOntologyMolecularFunctiontransmembrane receptor protein phosphatase activity

PTPRB PTPRH

6.32e-0417442GO:0019198
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRNA5 CHRNB4

6.32e-0417442GO:0022848
GeneOntologyMolecularFunctioncadherin binding

MACF1 PTPRB PTPRH SPTBN1 MPP7

8.64e-04339445GO:0045296
GeneOntologyMolecularFunctionankyrin binding

SPTBN4 SPTBN1

1.17e-0323442GO:0030506
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRNA5 CHRNB4

1.17e-0323442GO:0015464
GeneOntologyMolecularFunctionactin filament binding

SPTBN4 SPTBN5 MACF1 SPTBN1

1.55e-03227444GO:0051015
GeneOntologyBiologicalProcessextracellular transport

DNAI1 RFX3 WWP2 DNAH11

1.01e-0562454GO:0006858
GeneOntologyCellularComponentspectrin

SPTBN4 SPTBN5 SPTBN1

7.76e-079453GO:0008091
GeneOntologyCellularComponentacetylcholine-gated channel complex

CHRNA5 CHRNB4

6.78e-0418452GO:0005892
GeneOntologyCellularComponentendolysosome membrane

RNF167 TPCN2

8.40e-0420452GO:0036020
GeneOntologyCellularComponentspecific granule membrane

PTPRB RAB44 CHRNB4

9.92e-0491453GO:0035579
GeneOntologyCellularComponentcholinergic synapse

CHRNA5 CHRNB4

1.02e-0322452GO:0098981
GeneOntologyCellularComponentcortical actin cytoskeleton

SPTBN4 SPTBN5 SPTBN1

1.06e-0393453GO:0030864
GeneOntologyCellularComponentcell cortex

SPTBN4 SPTBN5 MACF1 SPTBN1 MPP7

1.17e-03371455GO:0005938
DomainActinin_actin-bd_CS

SPTBN4 SPTBN5 MACF1 SPTBN1

1.90e-0723424IPR001589
DomainACTININ_2

SPTBN4 SPTBN5 MACF1 SPTBN1

1.90e-0723424PS00020
DomainACTININ_1

SPTBN4 SPTBN5 MACF1 SPTBN1

1.90e-0723424PS00019
DomainSpectrin

SPTBN4 SPTBN5 MACF1 SPTBN1

1.90e-0723424PF00435
DomainSpectrin_repeat

SPTBN4 SPTBN5 MACF1 SPTBN1

5.04e-0729424IPR002017
DomainSpectrin/alpha-actinin

SPTBN4 SPTBN5 MACF1 SPTBN1

7.59e-0732424IPR018159
DomainSPEC

SPTBN4 SPTBN5 MACF1 SPTBN1

7.59e-0732424SM00150
DomainPH_dom-spectrin-type

SPTBN4 SPTBN5 SPTBN1

8.80e-079423IPR001605
DomainCH

SPTBN4 SPTBN5 MACF1 SPTBN1

1.35e-0565424SM00033
DomainCH

SPTBN4 SPTBN5 MACF1 SPTBN1

1.82e-0570424PF00307
Domain-

SPTBN4 SPTBN5 MACF1 SPTBN1

1.92e-05714241.10.418.10
DomainCH

SPTBN4 SPTBN5 MACF1 SPTBN1

2.15e-0573424PS50021
DomainCH-domain

SPTBN4 SPTBN5 MACF1 SPTBN1

2.39e-0575424IPR001715
DomainSpectrin_bsu

SPTBN4 SPTBN1

2.95e-054422IPR016343
DomainNicotinic_acetylcholine_rcpt

CHRNA5 CHRNB4

5.81e-0416422IPR002394
DomainZnf_RING-CH

RNF167 LTN1

6.57e-0417422IPR011016
DomainRINGv

RNF167 LTN1

6.57e-0417422SM00744
DomainAcetylcholine_rcpt_TM

CHRNA5 CHRNB4

1.21e-0323422IPR027361
Domain-

CHRNA5 CHRNB4

1.21e-03234221.20.120.370
DomainPH

SPTBN4 SPTBN5 ITSN1 SPTBN1

1.71e-03229424PF00169
DomainPTPc

PTPRB PTPRH

2.96e-0336422SM00194
DomainPH

SPTBN4 SPTBN5 ITSN1 SPTBN1

3.45e-03278424SM00233
DomainTYR_PHOSPHATASE_PTP

PTPRB PTPRH

3.47e-0339422PS50055
DomainPH_DOMAIN

SPTBN4 SPTBN5 ITSN1 SPTBN1

3.49e-03279424PS50003
DomainPH_domain

SPTBN4 SPTBN5 ITSN1 SPTBN1

3.54e-03280424IPR001849
DomainPTPase_domain

PTPRB PTPRH

3.83e-0341422IPR000242
DomainY_phosphatase

PTPRB PTPRH

3.83e-0341422PF00102
DomainNeurotransmitter_ion_chnl_CS

CHRNA5 CHRNB4

4.60e-0345422IPR018000
DomainRING

PEX12 RNF167 ATRX LTN1

4.79e-03305424SM00184
DomainNeur_chan_memb

CHRNA5 CHRNB4

4.80e-0346422PF02932
DomainNeur_chan_LBD

CHRNA5 CHRNB4

5.01e-0347422PF02931
DomainNeur_channel

CHRNA5 CHRNB4

5.01e-0347422IPR006201
DomainNeur_chan_lig-bd

CHRNA5 CHRNB4

5.01e-0347422IPR006202
DomainNEUROTR_ION_CHANNEL

CHRNA5 CHRNB4

5.01e-0347422PS00236
DomainNeurotrans-gated_channel_TM

CHRNA5 CHRNB4

5.01e-0347422IPR006029
Domain-

CHRNA5 CHRNB4

5.01e-03474222.70.170.10
DomainZnF_C3H1

PAN3 PARP12

5.22e-0348422SM00356
DomainZnf_RING

PEX12 RNF167 ATRX LTN1

6.05e-03326424IPR001841
Domainzf-RING_2

RNF167 LTN1

6.10e-0352422PF13639
DomainZnf_CCCH

PAN3 PARP12

7.54e-0358422IPR000571
DomainZF_C3H1

PAN3 PARP12

7.54e-0358422PS50103
Domain-

SPTBN4 SPTBN5 ITSN1 SPTBN1

1.13e-023914242.30.29.30
DomainTyr_Pase_AS

PTPRB PTPRH

1.17e-0273422IPR016130
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN4 SPTBN5 SPTBN1

1.39e-0610333MM15112
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN4 SPTBN5 SPTBN1

5.02e-0531333M877
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTBN4 SPTBN5 SPTBN1

9.32e-0538333MM14969
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA5 CHRNB4

1.89e-049332M27597
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA5 CHRNB4

1.89e-049332MM15313
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA5 CHRNB4

2.88e-0411332M883
PathwayREACTOME_RHOQ_GTPASE_CYCLE

WWP2 ITSN1 MPP7

3.30e-0458333MM15602
PathwayREACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA5 CHRNB4

3.46e-0412332M48008
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA5 CHRNB4

3.46e-0412332MM15312
PathwayREACTOME_RHOQ_GTPASE_CYCLE

WWP2 ITSN1 MPP7

3.47e-0459333M41812
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTBN4 SPTBN5 SPTBN1

4.22e-0463333M11187
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA5 CHRNB4

4.75e-0414332M757
PathwayREACTOME_L1CAM_INTERACTIONS

SPTBN4 SPTBN5 SPTBN1

5.28e-0468333MM14968
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA5 CHRNB4

5.47e-0415332MM14704
PathwayBIOCARTA_SPRY_PATHWAY

PTPRB EGF

6.25e-0416332MM1500
PathwayBIOCARTA_SPRY_PATHWAY

PTPRB EGF

7.07e-0417332M1389
PathwayREACTOME_SIGNALING_BY_NOTCH3

EGF WWP2

8.86e-0419332MM15594
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

EGF WWP2

1.54e-0325332M27879
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTBN4 SPTBN5 SPTBN1

1.71e-03102333M27648
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAI1 DNAH11

1.80e-0327332M47755
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTBN4 SPTBN5 SPTBN1

2.13e-03110333MM15350
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN4 SPTBN5 SPTBN1

6.99e-071348318796539
Pubmed

Increased severity of experimental colitis in alpha 5 nicotinic acetylcholine receptor subunit-deficient mice.

CHRNA5 CHRNB4

1.87e-06248215973160
Pubmed

Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice.

CHRNA5 CHRNB4

1.87e-06248235595472
Pubmed

Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures.

CHRNA5 CHRNB4

1.87e-06248214996991
Pubmed

Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.

CHRNA5 CHRNB4

1.87e-06248221555077
Pubmed

Nicotinic acetylcholine receptor α7 and β4 subunits contribute nicotine-induced apoptosis in periodontal ligament stem cells.

CHRNA5 CHRNB4

1.87e-06248222382680
Pubmed

alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors.

CHRNA5 CHRNB4

1.87e-0624829655874
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN4 SPTBN5 SPTBN1

1.98e-061848312119179
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTBN4 SPTBN5 SPTBN1

5.55e-06254838493579
Pubmed

Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population.

CHRNA5 CHRNB4

5.59e-06348223844051
Pubmed

Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.

CHRNA5 CHRNB4

5.59e-06348225471942
Pubmed

A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.

SPTBN4 SPTBN1

5.59e-06348211294830
Pubmed

In search of causal variants: refining disease association signals using cross-population contrasts.

CHRNA5 CHRNB4

5.59e-06348218759969
Pubmed

An association study on the CHRNA5/A3/B4 gene cluster, smoking and psoriasis vulgaris.

CHRNA5 CHRNB4

5.59e-06348225297392
Pubmed

The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.

CHRNA5 CHRNB4

5.59e-06348218163978
Pubmed

Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.

CHRNA5 CHRNB4

5.59e-06348222459873
Pubmed

CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

CHRNA5 CHRNB4

5.59e-06348223692359
Pubmed

Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.

CHRNA5 CHRNB4

5.59e-06348219671882
Pubmed

Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.

CHRNA5 CHRNB4

5.59e-06348222101982
Pubmed

Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.

CHRNA5 CHRNB4

5.59e-06348230453884
Pubmed

Variants in nicotinic receptors and risk for nicotine dependence.

CHRNA5 CHRNB4

5.59e-06348218519524
Pubmed

The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.

CHRNA5 CHRNB4

5.59e-06348222382757
Pubmed

The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.

CHRNA5 CHRNB4

5.59e-06348224750073
Pubmed

Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking.

CHRNA5 CHRNB4

5.59e-06348226010901
Pubmed

Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study.

CHRNA5 CHRNB4

5.59e-06348223458267
Pubmed

Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study.

CHRNA5 CHRNB4

5.59e-06348221646606
Pubmed

Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling.

CHRNA5 CHRNB4

5.59e-06348224647947
Pubmed

Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

CHRNA5 CHRNB4

5.59e-06348219859904
Pubmed

Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice.

CHRNA5 CHRNB4

5.59e-06348238902419
Pubmed

Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15.

CHRNA5 CHRNB4

5.59e-06348219628476
Pubmed

The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.

CHRNA5 CHRNB4

5.59e-06348220685379
Pubmed

Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes.

CHRNA5 CHRNB4

5.59e-06348222336398
Pubmed

Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes.

CHRNA5 CHRNB4

5.59e-06348218996504
Pubmed

Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.

CHRNA5 CHRNB4

5.59e-06348222042234
Pubmed

Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.

CHRNA5 CHRNB4

5.59e-06348226942719
Pubmed

Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior.

CHRNA5 CHRNB4

5.59e-06348222024278
Pubmed

Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility.

CHRNA5 CHRNB4

5.59e-06348220631687
Pubmed

Pleiotropic effects of Chr15q25 nicotinic gene cluster and the relationship between smoking, cognition and ADHD.

CHRNA5 CHRNB4

5.59e-06348227302872
Pubmed

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

CHRNA5 CHRNB4

5.59e-06348219429911
Pubmed

An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease.

CHRNA5 CHRNB4

5.59e-06348221228559
Pubmed

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight.

CHRNA5 CHRNB4

5.59e-06348222956269
Pubmed

Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.

CHRNA5 CHRNB4

5.59e-06348220808433
Pubmed

Role of genetic variants in the CHRNA5-CHRNA3-CHRNB4 cluster in nicotine dependence risk: importance of gene-environment interplay.

CHRNA5 CHRNB4

5.59e-06348219696770
Pubmed

A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

CHRNA5 CHRNB4

5.59e-06348218618000
Pubmed

The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.

CHRNA5 CHRNB4

5.59e-06348227758088
Pubmed

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.

CHRNA5 CHRNB4

5.59e-06348225293386
Pubmed

Hidden function of neuronal nicotinic acetylcholine receptor beta2 subunits in ganglionic transmission: comparison to alpha5 and beta4 subunits.

CHRNA5 CHRNB4

5.59e-06348215694199
Pubmed

Molecular mechanisms underlying behaviors related to nicotine addiction.

CHRNA5 CHRNB4

5.59e-06348223143843
Pubmed

The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review.

CHRNA5 CHRNB4

5.59e-06348233578531
Pubmed

Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

CHRNA5 CHRNB4

5.59e-06348222241830
Pubmed

Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

CHRNA5 CHRNB4

5.59e-06348220418889
Pubmed

Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach.

CHRNA5 CHRNB4

5.59e-06348211606319
Pubmed

Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population.

CHRNA5 CHRNB4

5.59e-06348221248747
Pubmed

Smoking status, snus use, and variation at the CHRNA5-CHRNA3-CHRNB4 locus in relation to obesity: the GLACIER study.

CHRNA5 CHRNB4

5.59e-06348223729684
Pubmed

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.

CHRNA5 CHRNB4

5.59e-06348218414406
Pubmed

Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers.

CHRNA5 CHRNB4

5.59e-06348226689306
Pubmed

Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

CHRNA5 CHRNB4

5.59e-06348220886544
Pubmed

Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice.

CHRNA5 CHRNB4

5.59e-06348220496163
Pubmed

Role of CHRNA5-A3 genetic Locus variants and developing drug for chronic obstructive pulmonary disease.

CHRNA5 CHRNB4

5.59e-06348223061658
Pubmed

Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits.

CHRNA5 CHRNB4

5.59e-0634821572664
Pubmed

Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966.

CHRNA5 CHRNB4

5.59e-06348223029550
Pubmed

Nicotinic receptor gene variants influence susceptibility to heavy smoking.

CHRNA5 CHRNB4

5.59e-06348219029397
Pubmed

β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.

SPTBN4 SPTBN1

5.59e-06348232425157
Pubmed

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

CHRNA5 CHRNB4

5.59e-06348219706762
Pubmed

The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion.

CHRNA5 CHRNB4

5.59e-06348230891952
Pubmed

Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.

CHRNA5 CHRNB4

5.59e-06348225474695
Pubmed

Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice.

CHRNA5 CHRNB4

5.59e-06348225384568
Pubmed

Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.

CHRNA5 CHRNB4

5.59e-06348220485328
Pubmed

Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.

CHRNA5 CHRNB4

1.12e-05448221747048
Pubmed

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

CHRNA5 CHRNB4

1.12e-05448218385739
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAI1 DNAH11

1.12e-05448218492703
Pubmed

NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas.

CHRNA5 CHRNB4

1.12e-05448224719457
Pubmed

Subunit composition of α5-containing nicotinic receptors in the rodent habenula.

CHRNA5 CHRNB4

1.12e-05448222380605
Pubmed

Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.

CHRNA5 CHRNB4

1.12e-05448225072098
Pubmed

Three types of cilia including a novel 9+4 axoneme on the notochordal plate of the rabbit embryo.

RFX3 DNAH11

1.12e-05448217061268
Pubmed

Genetic variability of smoking persistence in African Americans.

CHRNA5 CHRNB4

1.12e-05448221436384
Pubmed

Low ethanol concentration alters CHRNA5 RNA levels during early human development.

CHRNA5 CHRNB4

1.86e-05548220438829
Pubmed

Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.

CHRNA5 CHRNB4

1.86e-05548220377613
Pubmed

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

CHRNA5 CHRNB4

1.86e-05548218385738
Pubmed

Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin.

PTPRB PTPRH

1.86e-05548228926625
Pubmed

Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study.

CHRNA5 CHRNB4

1.86e-05548220554942
Pubmed

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

DNAI1 DNAH11

1.86e-05548222499950
Pubmed

Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.

CHRNA5 CHRNB4

1.86e-0554829193799
Pubmed

Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.

CHRNA5 CHRNB4

1.86e-05548218780872
Pubmed

Nicotinic acetylcholine receptors: from structure to brain function.

CHRNA5 CHRNB4

1.86e-05548212783266
Pubmed

Single-channel properties of α3β4, α3β4α5 and α3β4β2 nicotinic acetylcholine receptors in mice lacking specific nicotinic acetylcholine receptor subunits.

CHRNA5 CHRNB4

2.79e-05648223613527
Pubmed

Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans.

CHRNA5 CHRNB4

2.79e-05648220587604
Pubmed

Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task.

CHRNA5 CHRNB4

2.79e-05648215922075
Pubmed

The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites.

PTPRB PTPRH

2.79e-05648226063811
Pubmed

Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse.

CHRNA5 CHRNB4

2.79e-0564822004777
Pubmed

TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.

CHRNA5 CHRNB4

2.79e-05648221168125
Pubmed

α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion.

CHRNA5 CHRNB4

2.79e-05648221485013
Pubmed

RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.

RFX3 DNAH11

3.90e-05748222233545
Pubmed

Distribution of neuronal nicotinic acetylcholine receptor gene restriction fragment length polymorphisms in inbred and partially inbred mice.

CHRNA5 CHRNB4

3.90e-0574828563774
Pubmed

Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

CHRNA5 CHRNB4

3.90e-0574829009220
Pubmed

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.

DNAI1 DNAH11

3.90e-05748233139725
Pubmed

Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.

CHRNA5 CHRNB4

3.90e-0574821505988
Pubmed

Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

CHRNA5 CHRNB4

5.19e-05848227344019
Pubmed

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

CHRNA5 CHRNB4

6.67e-0594828906617
Pubmed

Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.

CHRNA5 CHRNB4

6.67e-05948219228980
Cytoband15q24

CHRNA5 CHRNB4

2.22e-042148215q24
CytobandEnsembl 112 genes in cytogenetic band chr15q15

SPTBN5 PPP1R14D STRC

5.01e-04147483chr15q15
CytobandXq21.1

ATRX BRWD3

5.54e-0433482Xq21.1
Cytoband12q13.12

FAM186B FAM186A

7.35e-043848212q13.12
Cytoband15q11.2

GOLGA6L2 GOLGA6L1 GOLGA6L22

7.90e-0417248315q11.2
CytobandEnsembl 112 genes in cytogenetic band chr15q11

GOLGA6L2 GOLGA6L1 GOLGA6L22

1.54e-03217483chr15q11
Cytoband4q25

ELOVL6 EGF

2.27e-03674824q25
CytobandEnsembl 112 genes in cytogenetic band chr4q25

ELOVL6 EGF

4.13e-0391482chr4q25
CytobandEnsembl 112 genes in cytogenetic band chrXq21

ATRX BRWD3

9.90e-03143482chrXq21
GeneFamilyEF-hand domain containing|Spectrins

SPTBN4 SPTBN5 SPTBN1

1.75e-0773231113
GeneFamilyCholinergic receptors nicotinic subunits

CHRNA5 CHRNB4

3.59e-0416322173
GeneFamilyDyneins, axonemal

DNAI1 DNAH11

4.06e-0417322536
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRB PTPRH

6.24e-0421322813
GeneFamilyX-linked mental retardation|Angiotensin receptors

ATRX BRWD3

3.95e-0353322103
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN4 ITSN1 SPTBN1

5.67e-03206323682
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

MACF1 PTPRB PAN3 RFX3 SPTBN1

4.66e-06137475M39241
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TTC39B MACF1 TEX11 USP9Y RFX3

2.03e-061934859337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

TTC39B MACF1 PTPRB MRC2 SPTBN1

2.30e-06198485ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellPND01-03-samps|World / Age Group, Lineage, Cell class and subclass

PTPRB PAN3 TEX11 SPTBN1

2.72e-051614841973b112d8d67aacc02751797d0148e7b53bfa66
ToppCellCiliated_cells-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DNAI1 FMO2 RFX3 DNAH11

4.58e-0518448407c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Alveolar_Mac|normal_Pleural_Fluid / Location, Cell class and cell subclass

GLA MRC2 ITSN1 CC2D2B

4.77e-051864843314def702fe6a5056d0dadbb3a587c5d1a16412
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 PTPRB ATRX SPTBN1

5.18e-05190484d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO2 MRC2 SNX7 ITSN1

5.18e-05190484990ac07f4b0a22041daac7502f74fafd6d258cba
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO2 MRC2 SNX7 ITSN1

5.18e-05190484fc9bbe5e6e0ec3cfa47bf479d8b09a0fc53169cc
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO2 MRC2 SNX7 ITSN1

5.18e-0519048439ecdf8815e235771132684dfc1aff1917e20965
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39B ATRX BRWD3 SPTBN1

5.29e-0519148460c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39B ATRX BRWD3 SPTBN1

5.29e-0519148409db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39B ATRX BRWD3 SPTBN1

5.29e-05191484973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

DNAI1 MACF1 SPTBN1 DNAH11

5.85e-051964846d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

DNAI1 MACF1 SPTBN1 DNAH11

5.85e-05196484af4cdc61830685a888a1209826c23bcf54a43084
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TTC39B MACF1 TEX11 RFX3

5.97e-0519748457ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TTC39B MACF1 USP9Y ATRX

6.20e-05199484f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_Myelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SPTBN5 PEX12 GADD45GIP1 CHRNB4

6.20e-051994844e4bdcd2e8b518156d5ebd294804180acaa3566b
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MACF1 PTPRB ATRX SPTBN1

6.33e-05200484dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MACF1 PTPRB ATRX SPTBN1

6.33e-05200484a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MAB21L3 FAM186B CHRNA5

9.51e-058248301a4d47d9e0dee68a5277ed1534338cec80f75d1
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MAB21L3 FAM186B CHRNA5

9.51e-0582483c1489097c291f413f3cfa5e26f8182ec872328fd
ToppCellRA-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

GPRC6A STRC FAM186A

2.59e-041154830a37816898eaa18ae49d4d936e1a760f089e0ceb
ToppCellControl-Epithelial_alveolar-Mes-Like|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FMO2 RAB44 CHRNA5

2.65e-04116483df7609503782d8d7e4f31ed2a626916e5474d5bc
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Intermediate|GW19 / Sample Type, Dataset, Time_group, and Cell type.

TTC39B PEX12 TPCN2

2.93e-04120483eb5b88c47dd4a6f9b55ace24f19d4e81d4ed31e1
ToppCellControl-Epithelial_alveolar-Mes-Like-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FMO2 RAB44 CHRNA5

3.46e-04127483556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF167 RAB44 MPP7

3.96e-04133483f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF167 RAB44 MPP7

3.96e-04133483292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCell21-Trachea-Immune-Immune|Trachea / Age, Tissue, Lineage and Cell class

MAB21L3 PTPRH CHRNA5

4.05e-041344834f0465324cc5b443ebadb68aef63be79b74f6ff9
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAI1 PTPRB FAM186B

4.32e-04137483b831d917f5073ccff158662adb281d34f023126a
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAI1 PTPRB FAM186B

4.32e-04137483cf3e928d9a7a7349840bb87475a42a07f65b94f0
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAI1 PTPRB FAM186B

4.32e-041374835d82d6c7eef4ec7a7fae60e37fb956488314987e
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe-9|TCGA-Kidney / Sample_Type by Project: Shred V9

SPTBN4 FAM184B GPRC6A

4.51e-04139483a93b861906d7f01ff715084f99152ec83529f8b3
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe|TCGA-Kidney / Sample_Type by Project: Shred V9

SPTBN4 FAM184B GPRC6A

4.60e-04140483bc5bed94c33129391ca35791febb55cc4cdff989
ToppCellLPS-antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GLA ELOVL6 RAB44

5.00e-04144483013223bb2f31eb5bebdbd0908b797d28b96c6f7b
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FMO2 PTPRB BMP15

5.52e-04149483d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC39B MRPL19 ATRX

5.96e-041534835ac4b97d35c1029a5fc625239f92e35136c4d832
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 PEX12 ITSN1

6.19e-041554839b26ade19488511c72b64335011d2dcd81e8f167
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 PEX12 ITSN1

6.19e-04155483cd2f3ad4f131588325a667b6724e530d821fbe30
ToppCellfacs-Skin-nan-24m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEX11 USP9Y FAM186B

6.19e-04155483fa2776d258e0420b2895de1008e292ad7725dac0
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 PEX12 ITSN1

6.19e-041554834246709e27703b94529369abbed5763e4002e79d
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRB SPTBN1 CCDC7

6.19e-041554838fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellAdult-Immune-enucleated_erythrocyte|Adult / Lineage, Cell type, age group and donor

PEX12 RAB44 CHRNA5

6.19e-04155483e2d07ee4348d2c1d3552a8d0337ea42777c31f9c
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

DNAI1 FAM186B DNAH11

6.31e-0415648310d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellControl-Epithelial_airway|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAI1 FMO2 DNAH11

6.54e-0415848335aee1c3b92169e73569331022833cb44ab7e7e8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TTC39B FAM184B MPP7

6.79e-041604831e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCelldroplet-Lung-30m-Hematologic-myeloid-neutrophil|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TTC39B RNF167 RAB44

7.04e-041624839c9a63adb692651ea5a52cc77b02c5ce11d0ccea
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39B RNF167 RAB44

7.04e-04162483dddf7a3901ae59e3494d8a6740db0fa15cc96d47
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

MACF1 USP9Y SPTBN1

7.04e-04162483b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCelldroplet-Lung-30m-Hematologic-myeloid-neutrophil-neutrophil|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TTC39B RNF167 RAB44

7.04e-041624831d29983b22f963b34e72cfd1eec328d2d7c4932f
ToppCelldroplet-Lung-LUNG-30m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39B RNF167 RAB44

7.04e-041624832a4e09545e9874519f0f56e81065104987d81cd6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN5 FMO2 PTPRB

7.16e-041634831feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

MACF1 FMO2 MRC2

7.16e-04163483f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRH WWP2 PARP12

7.82e-0416848303896466698a79f7f1ad862cb7e05585260e2a5a
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

PTPRB RAB44 GOLGA6L1

7.95e-04169483337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Basophil|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTBN4 GLA RAB44

7.95e-04169483b23d0aaa2da333b9c69a7aee862d5a5d2a1bf79b
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

PTPRB RAB44 GOLGA6L1

7.95e-04169483605cc2638271803cf1d972ab3fa8f13f89666376
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 RFX3 DNAH11

7.95e-04169483fba841664939c771881ba97f14ef1df6635c04ff
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTBN4 GLA RAB44

7.95e-0416948383d1bcf33872b01ea9614f608a3e4ab30df25c7e
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 RFX3 DNAH11

7.95e-0416948314aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MACF1 FMO2 PTPRB

8.09e-041704837fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCellCiliated_cells-A-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

FMO2 RFX3 DNAH11

8.09e-041704838b7ef1464ea589886b575ebad5447b085cbdcdba
ToppCell368C-Lymphocytic-ILC|368C / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 MPP7 CCDC7

8.23e-041714833b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell368C-Lymphocytic-ILC-ILC-2|368C / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 MPP7 CCDC7

8.23e-04171483fd01076574dcc82bfd4a1538812500543b16794f
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FMO2 MRC2 GOLGA6L1

8.23e-041714836a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FMO2 MRC2 GOLGA6L1

8.23e-041714839be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCelldroplet-Lung-nan-21m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAB21L3 EGF ZNF471

8.23e-04171483159ce6d5513008532dd7785b915b3fe7440cc4b2
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue-5|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

DNAI1 FMO2 BMP15

8.37e-041724836b8a8d3b97c10b9d092307eed3cacbd2745df185
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 PAN3 ATRX

8.51e-04173483869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 RFX3 DNAH11

8.51e-04173483c3762655caa79ac4879876f470d32578a3c93b01
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPRC6A MPP7 PARP12

8.51e-041734838ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 PAN3 ATRX

8.51e-041734830672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TTC39B FAM184B MPP7

8.51e-041734830bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 PAN3 ATRX

8.51e-04173483870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAM184B MAB21L3 MPP7

8.80e-041754831d8da48236549c01381f777ce5b2937f9f86acc2
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MACF1 FMO2 PTPRB

8.80e-04175483282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLA RFX3 DNAH11

8.94e-041764833766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 FMO2 MRC2

8.94e-04176483cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TTC39B FAM184B MPP7

8.94e-04176483c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLA RFX3 DNAH11

8.94e-04176483aa1bada2175d8370fc71939a607407155259d195
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO2 PTPRB SPTBN1

9.09e-04177483ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO2 PTPRB SPTBN1

9.09e-04177483f471f7747d6e8db7546899019af9508f48a14f89
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO2 PTPRB SPTBN1

9.09e-04177483cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

SPTBN5 PTPRB SPTBN1

9.09e-04177483f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B ATRX DNAH11

9.09e-04177483426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO2 PTPRB ATRX

9.24e-0417848301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPRB EGF MPP7

9.39e-04179483abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPRB EGF MPP7

9.39e-041794830b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FMO2 PTPRB SPTBN1

9.39e-041794838f9e538c822940785130297712b75131812a4603
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PTPRB CHRNA5 SPTBN1

9.39e-04179483754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 RFX3 DNAH11

9.39e-041794835e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MACF1 PTPRB SPTBN1

9.54e-04180483493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 PTPRB SPTBN1

9.54e-04180483423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellMatrixFB-Fibroblast-A|MatrixFB / shred on cell class and cell subclass (v4)

MACF1 FMO2 MRC2

9.54e-04180483adc64ad6033af705dd7b9163a83e20ef5c59f6eb
ToppCell368C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 ELOVL6 CCDC7

9.54e-04180483eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 GOLGA6L22 DNAH11

9.54e-041804831f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell368C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 ELOVL6 CCDC7

9.54e-04180483ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 PTPRB SPTBN1

9.54e-04180483dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|(2)_5-FU / Stress and Cell class

MRC2 SNX7 WWP2

9.70e-0418148356ae86072858c156681507aecd1bc6cb0a3372d2
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 ATRX SPTBN1

9.85e-041824831710eab3037a87609d21838be2d2d29c3bc36651
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 ATRX SPTBN1

9.85e-04182483f8c73baaaca145e2efc48f10f636feb79c8fc779
ComputationalGenes in the cancer module 67.

SPTBN4 USP9Y ZNF471 CCDC7 DNAH11

2.66e-04227285MODULE_67
DrugADPribulose

SPTBN4 SPTBN5 SPTBN1

2.32e-0613473CID000197570
DrugPRODAN

SPTBN4 SPTBN5 SPTBN1

3.69e-0615473CID000028127
Diseaselung small cell carcinoma (is_marker_for)

ATRX CHRNA5 CHRNB4

1.83e-0616453DOID:5409 (is_marker_for)
Diseasecocaine abuse (is_implicated_in)

CHRNA5 CHRNB4

2.27e-062452DOID:809 (is_implicated_in)
Diseaselung adenocarcinoma (is_marker_for)

PTPRB ATRX CHRNA5 CHRNB4

8.73e-0685454DOID:3910 (is_marker_for)
DiseaseKartagener syndrome (is_implicated_in)

DNAI1 DNAH11

1.36e-054452DOID:0050144 (is_implicated_in)
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTBN4 SPTBN1

1.36e-054452DOID:0050882 (implicated_via_orthology)
Diseaselung squamous cell carcinoma (is_marker_for)

ATRX CHRNA5 CHRNB4

2.28e-0536453DOID:3907 (is_marker_for)
Diseasevisceral heterotaxy (implicated_via_orthology)

DNAI1 RFX3 DNAH11

2.48e-0537453DOID:0050545 (implicated_via_orthology)
Diseaselung adenocarcinoma (is_implicated_in)

EGF CHRNA5 CHRNB4

5.81e-0549453DOID:3910 (is_implicated_in)
Diseaselung non-small cell carcinoma (is_implicated_in)

PTPRB EGF CHRNA5 CHRNB4

6.05e-05139454DOID:3908 (is_implicated_in)
DiseaseKartagener syndrome (implicated_via_orthology)

DNAI1 DNAH11

2.05e-0414452DOID:0050144 (implicated_via_orthology)
DiseaseBronchiectasis

DNAI1 DNAH11

5.15e-0422452C0006267
Diseaseglioblastoma (is_implicated_in)

PTPRB EGF

6.14e-0424452DOID:3068 (is_implicated_in)
Diseaselung squamous cell carcinoma (is_implicated_in)

CHRNA5 CHRNB4

6.14e-0424452DOID:3907 (is_implicated_in)
DiseaseDrug habituation

FAM184B CHRNA5 MPP7

7.26e-04115453C0013170
DiseaseSubstance-Related Disorders

FAM184B CHRNA5 MPP7

7.26e-04115453C0236969
DiseaseDrug abuse

FAM184B CHRNA5 MPP7

7.26e-04115453C0013146
DiseaseDrug Use Disorders

FAM184B CHRNA5 MPP7

7.26e-04115453C0013222
DiseaseDrug Dependence

FAM184B CHRNA5 MPP7

7.26e-04115453C1510472
DiseaseSubstance Dependence

FAM184B CHRNA5 MPP7

7.26e-04115453C0038580
DiseaseSubstance Use Disorders

FAM184B CHRNA5 MPP7

7.26e-04115453C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

FAM184B CHRNA5 MPP7

7.26e-04115453C0029231
DiseasePrescription Drug Abuse

FAM184B CHRNA5 MPP7

7.26e-04115453C4316881
DiseaseSubstance abuse problem

FAM184B CHRNA5 MPP7

7.45e-04116453C0740858
DiseaseMental Retardation, X-Linked

ATRX BRWD3

8.99e-0429452C1136249
DiseasePrimary ciliary dyskinesia

DNAI1 DNAH11

1.39e-0336452cv:C0008780

Protein segments in the cluster

PeptideGeneStartEntry
REQIMTTNVWLKQEW

CHRNB4

71

P30926
SLFKWFQWQVNQMEE

CCDC7

156

Q96M83
KWAQQVLQRLQMFWS

DNAH11

636

Q96DT5
WQYQQQEWKSIVLDM

BRWD3

391

Q6RI45
SWNQQVTQMALWAIM

GLA

276

P06280
WQVKWQKDDMDQNLN

DNAI1

436

Q9UI46
QLWLEEEEMWQQRQK

FAM186B

491

Q8IYM0
IPWLMNEQKLFEWAN

CC2D2B

661

Q6DHV5
QMEIWQLWGQLRQEE

RAB44

166

Q7Z6P3
VAVQQWRNWMLQLST

LTN1

1671

O94822
FWKMVWEQNVHNIVM

PTPRB

1786

P23467
MQQSVSQALWQWQEK

FAM184B

236

Q9ULE4
WKEMDITQLVQQRFW

BMP15

181

O95972
DIQGLNMKQIWWAVA

CSNKA2IP

566

A0A1B0GTH6
ILQIMSQDDATWWQA

MPP7

261

Q5T2T1
EMNNAWENLNKTWKE

MACF1

2216

O94854
WIGLNDLKLQMNFEW

MRC2

441

Q9UBG0
WNRLNQQQEEKMWRQ

GOLGA6L1

291

Q8N7Z2
QEENMWEQEEKEWQQ

GOLGA6L2

476

Q8N9W4
WNRLNQQQEEKMWRQ

GOLGA6L22

241

H0YM25
QQWLEVEQFMKSLWQ

MAB21L3

111

Q8N8X9
ALWEVYQWQKGQMQK

PARP12

536

Q9H0J9
IEMNINKMWIASDNW

GPRC6A

291

Q5T6X5
NMVWWNRVTENNLQT

PAN3

271

Q58A45
QFNENEAIQWMQENW

ELOVL6

16

Q9H5J4
QLMTTNVWLKQEWID

CHRNA5

91

P30532
ALNWMNEFEKWQEGL

ATRX

1631

P46100
MAINWINEEVIWSNQ

EGF

121

P01133
KNDVITVLEQQDMWW

ITSN1

936

Q15811
AVKWMIEQQMNRWFN

FMO2

251

Q99518
MIVNWQQQQRENWEK

GADD45GIP1

131

Q8TAE8
EQQSQKQWQEEEMWK

FAM186A

876

A6NE01
LQRWLEMEQWVDAQV

PPP1R14D

66

Q9NXH3
LEQWAAWLDNVMMQA

RFX3

566

P48380
NMVWNSEEIQQQIWI

RNF167

121

Q9H6Y7
VNMAWEGWFLVQQLR

PEX12

166

O00623
KADWERWKQNMQNDI

SNX7

331

Q9UNH6
PWSEQQAQFLWKKMQ

STRC

1161

Q7RTU9
LQEWKQDVAELMQWM

SPTBN5

1316

Q9NRC6
CELWIDEKEQWLNNM

SPTBN1

861

Q01082
EQQMKEAQKWNQPWL

MRPL19

251

P49406
IQWFWQVVKEMDNEK

WWP2

776

O00308
ELMWINVFQQNWMQA

TTC39B

436

Q5VTQ0
DIQIEEMAVNLWNWA

TEX11

66

Q8IYF3
WEWLQQMLEVHQFAQ

SPTBN4

2041

Q9H254
WLTAERMAEWIQQNN

USP9Y

381

O00507
IDFSQEEWQWMNPAQ

ZNF471

21

Q9BX82
LQNETQTKNSVMLWW

PTPRH

571

Q9HD43
LWNLMVVNNWQVFLD

TPCN2

646

Q8NHX9