Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	DCPS RC3H1 DHX9 CNOT6 CNOT6L TNKS1BP1 CNOT2	1.29e-06	65	175	7	GO:0000288
GeneOntologyBiologicalProcess	positive regulation of cytoplasmic mRNA processing body assembly	CNOT6 CNOT6L CNOT2	1.18e-05	6	175	3	GO:0010606
GeneOntologyBiologicalProcess	regulation of cytoplasmic mRNA processing body assembly	CNOT6 CNOT6L CNOT2	3.26e-05	8	175	3	GO:0010603
GeneOntologyBiologicalProcess	P-body assembly	RC3H1 CNOT6 CNOT6L CNOT2	3.91e-05	23	175	4	GO:0033962
GeneOntologyCellularComponent	CCR4-NOT complex	CNOT6 CNOT6L TNKS1BP1 CNOT2	8.54e-06	16	178	4	GO:0030014
Domain	Leu-rich_rpt	NLRP11 FMOD VASN NTRK1 LRSAM1 LRRC49 TLR7 CPN2 LRRC58 NLRP2 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 NLRC5 LRRD1 PHLPP2 GP1BA	7.09e-13	271	171	20	IPR001611
Domain	-	NLRP11 FMOD VASN NTRK1 LRSAM1 LRRC49 TLR7 CPN2 LRRC58 NLRP2 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 NLRC5 FBXO33 LRRD1 PHLPP2 GP1BA	1.88e-12	321	171	21	3.80.10.10
Domain	L_dom-like	NLRP11 FMOD VASN NTRK1 LRSAM1 LRRC49 TLR7 CPN2 LRRC58 NLRP2 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 NLRC5 FBXO33 LRRD1 PHLPP2 GP1BA	2.84e-12	328	171	21	IPR032675
Domain	LRR_8	FMOD VASN NTRK1 LRSAM1 TLR7 CPN2 LRRC58 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 LRRD1 PHLPP2 GP1BA	4.36e-12	171	171	16	PF13855
Domain	LRR	FMOD VASN LRSAM1 LRRC49 TLR7 CPN2 LRRC58 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 NLRC5 LRRD1 PHLPP2 GP1BA	4.67e-12	201	171	17	PS51450
Domain	LRR_TYP	FMOD VASN LRSAM1 LRRC49 TLR7 CPN2 LRRC58 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 LRRD1 PHLPP2 GP1BA	7.40e-12	177	171	16	SM00369
Domain	Leu-rich_rpt_typical-subtyp	FMOD VASN LRSAM1 LRRC49 TLR7 CPN2 LRRC58 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 LRRD1 PHLPP2 GP1BA	7.40e-12	177	171	16	IPR003591
Domain	LRR_1	FMOD VASN LRSAM1 LRRC49 TLR7 CPN2 LRRC58 OMG CNOT6 LRRN3 CNOT6L TLR3 LRRC1 NLRC5 LRRD1 PHLPP2	1.84e-10	219	171	16	PF00560
Domain	LRRNT	FMOD VASN TLR7 CPN2 OMG LRRN3 TLR3 GP1BA	3.27e-06	98	171	8	IPR000372
Domain	LRRNT	FMOD VASN TLR7 CPN2 OMG LRRN3 TLR3 GP1BA	3.27e-06	98	171	8	SM00013
Domain	LRRNT	FMOD VASN CPN2 OMG LRRN3 GP1BA	8.67e-06	53	171	6	PF01462
Domain	LRRCT	VASN TLR7 CPN2 LRRN3 TLR3	1.00e-05	32	171	5	PF01463
Domain	Cys-rich_flank_reg_C	VASN NTRK1 TLR7 CPN2 LRRN3 TLR3 GP1BA	1.88e-05	90	171	7	IPR000483
Domain	LRRCT	VASN NTRK1 TLR7 CPN2 LRRN3 TLR3 GP1BA	1.88e-05	90	171	7	SM00082
Domain	KELK	CDC42BPA CDC42BPB	8.33e-05	2	171	2	IPR031597
Domain	KELK	CDC42BPA CDC42BPB	8.33e-05	2	171	2	PF15796
Domain	Sp1_fam	SP1 SP2 SP3	8.63e-05	10	171	3	IPR030450
Domain	Ig-like_fold	EPHB3 HSPG2 SEMA4B MYCBP2 VASN NTRK1 CCDC141 RIMBP3 HAVCR2 LRRN3 HMCN2 PTPRK SIGLEC6 NFKB2 PKHD1 RIMBP3B IL7R CDON	8.69e-05	706	171	18	IPR013783
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.56e-04	12	171	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.56e-04	12	171	3	IPR027970
Domain	PBD	WASL CDC42BPA CDC42BPB	3.87e-04	16	171	3	SM00285
Domain	-	EPHB3 HSPG2 MYCBP2 VASN NTRK1 CCDC141 RIMBP3 HAVCR2 LRRN3 PTPRK SIGLEC6 NFKB2 PKHD1 RIMBP3B IL7R CDON	4.01e-04	663	171	16	2.60.40.10
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPA CDC42BPB	4.94e-04	4	171	2	IPR014930
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPA CDC42BPB	4.94e-04	4	171	2	PD011252
Domain	DMPK_coil	CDC42BPA CDC42BPB	4.94e-04	4	171	2	PF08826
Domain	FN3	EPHB3 VASN RIMBP3 LRRN3 PTPRK RIMBP3B IL7R CDON	5.04e-04	199	171	8	PS50853
Domain	FN3_dom	EPHB3 VASN RIMBP3 LRRN3 PTPRK RIMBP3B IL7R CDON	6.96e-04	209	171	8	IPR003961
Domain	CRIB	WASL CDC42BPA CDC42BPB	7.67e-04	20	171	3	PS50108
Domain	CRIB_dom	WASL CDC42BPA CDC42BPB	8.88e-04	21	171	3	IPR000095
Domain	FG_GAP	ITGA10 ITGA5 ITFG1	1.02e-03	22	171	3	PS51470
Domain	NACHT	NLRP11 NLRP2 NLRC5	1.17e-03	23	171	3	PS50837
Domain	NACHT_NTPase	NLRP11 NLRP2 NLRC5	1.17e-03	23	171	3	IPR007111
Domain	Ubiquilin	UBQLNL UBQLN1	1.22e-03	6	171	2	IPR015496
Domain	FG-GAP	ITGA10 ITGA5 ITFG1	1.32e-03	24	171	3	PF01839
Domain	FG-GAP	ITGA10 ITGA5 ITFG1	1.32e-03	24	171	3	IPR013517
Domain	Keratin_2_head	KRT1 KRT78 KRT77	1.32e-03	24	171	3	IPR032444
Domain	Keratin_2_head	KRT1 KRT78 KRT77	1.32e-03	24	171	3	PF16208
Domain	HR1_rho-bd	CDC42BPA TBC1D4 KRT77	1.50e-03	25	171	3	IPR011072
Domain	LRR_6	NLRP11 NLRP2 TLR3 NLRC5	1.61e-03	55	171	4	PF13516
Domain	Keratin_II	KRT1 KRT78 KRT77	1.68e-03	26	171	3	IPR003054
Domain	RNA_pol_II-bd	CHERP RPRD2	1.70e-03	7	171	2	IPR006903
Domain	CTD_bind	CHERP RPRD2	1.70e-03	7	171	2	PF04818
Domain	Plakophilin/d_Catenin	ARVCF PKP2	1.70e-03	7	171	2	IPR028435
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN	CNOT6 CNOT6L TNKS1BP1 CNOT2	1.44e-05	18	121	4	MM15336
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN	CNOT6 CNOT6L TNKS1BP1 CNOT2	2.76e-05	21	121	4	M27634
Pathway	REACTOME_DEADENYLATION_OF_MRNA	CNOT6 CNOT6L TNKS1BP1 CNOT2	4.80e-05	24	121	4	MM15090
Pathway	REACTOME_DEADENYLATION_OF_MRNA	CNOT6 CNOT6L TNKS1BP1 CNOT2	5.68e-05	25	121	4	M13492
Pathway	REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	DCPS CNOT6 CNOT6L TNKS1BP1 CNOT2	9.69e-05	54	121	5	MM15089
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	SP1 NCOA6 CHD9 MED1 SEC24B	1.06e-04	55	121	5	M27001
Pathway	REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	DCPS CNOT6 CNOT6L TNKS1BP1 CNOT2	1.15e-04	56	121	5	M839
Pathway	REACTOME_M_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_MATERNALLY_STORED_FACTORS	CNOT6 CNOT6L TNKS1BP1 CNOT2	1.74e-04	33	121	4	M48026
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES	CNOT6 CNOT6L TNKS1BP1 CNOT2	1.96e-04	34	121	4	MM15325
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	ITGA10 GP1BA COL1A2	3.18e-04	16	121	3	M9450
Pathway	REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1	DHX9 NFKB2 TLR3	3.84e-04	17	121	3	M583
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	SP1 NCOA6 CHD9 MED1	4.49e-04	42	121	4	M27172
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	NCOA6 CHD9 MED1	4.58e-04	18	121	3	M26942
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 SEMA4B NCOA6 CDC42BPA EP400 MYCBP2 TMEM94 MTMR8 HECTD4 NSD1 ITGA5 ZNF236 CDC42BPB WDR59 RYR1 SBNO2 URB1 KMT2D ARVCF CLN3 NFKB2 NLRC5 ZFYVE26 TNKS1BP1 MBD5 BRAT1 ABCC10	2.05e-11	1105	179	27	35748872
Pubmed	RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.	RC3H1 CNOT6 CNOT6L TNKS1BP1 CNOT2 RAVER1	6.24e-10	20	179	6	34887419
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	TPR KRT1 WASL CAD CDC42BPA MYCBP2 CDC42BPB DHX9 URB1 KRT77 PKHD1	9.14e-09	202	179	11	24639526
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	1.01e-08	6	179	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	1.01e-08	6	179	4	25930072
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	CNOT6 CNOT6L TNKS1BP1 CNOT2 RAVER1	8.38e-08	22	179	5	18377426
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCOA6 CDC42BPA EP400 KIF16B HECTD4 E2F3 PCDHA3 WDR43 CNOT6 ZNF532 SEMA5B RPRD2 TNKS1BP1 MINDY1 NIN	1.17e-07	529	179	15	14621295
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR SP1 NCOA6 RNF169 EP400 MYCBP2 NELFB POU2F1 MED1 INTS3 DHX9 KMT2D TBC1D4 CLN3 PURB TNKS1BP1 CLUH RAVER1	1.20e-07	774	179	18	15302935
Pubmed	Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix.	SP1 CAD POU2F1	1.34e-07	3	179	3	9525610
Pubmed	Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.	SP1 SP2 SP3	1.34e-07	3	179	3	25793500
Pubmed	Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.	CNOT6 CNOT6L TNKS1BP1 CNOT2	3.25e-07	12	179	4	17452450
Pubmed	Human Ccr4-Not complexes contain variable deadenylase subunits.	CNOT6 CNOT6L TNKS1BP1 CNOT2	3.25e-07	12	179	4	19558367
Pubmed	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.	CNOT6 CNOT6L TNKS1BP1 CNOT2	3.25e-07	12	179	4	31320642
Pubmed	Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.	SP1 SP2 SP3	5.34e-07	4	179	3	27889927
Pubmed	Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.	SP1 SP2 SP3	1.33e-06	5	179	3	10547281
Pubmed	Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.	SP1 SP3 POU2F1	1.33e-06	5	179	3	16061936
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	UBQLNL BAZ2B TOPAZ1 DISC1 PPFIA2 COQ8B NELFB OMG RYR1 DHX9 URB1 TBC1D4 TLR3 PKHD1 GP1BA COL1A2	1.50e-06	736	179	16	29676528
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 SP2 SEMA4B RNF169 TCAF1 BAZ2B RC3H1 NELFB CDC42BPB WDR59 N4BP2 DISP3 MBD5	1.88e-06	493	179	13	15368895
Pubmed	Differential intranuclear organization of transcription factors Sp1 and Sp3.	SP1 SP2 SP3	2.65e-06	6	179	3	15987735
Pubmed	Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.	SP1 SP2 SP3	2.65e-06	6	179	3	16201967
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	NLRP11 TPR NCOA6 CAD CDC42BPA NSD1 DHX9 KMT2D FAM186A	3.81e-06	234	179	9	36243803
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOA6 EP400 NSD1 POU2F1 MED1 KMT2D	4.64e-06	83	179	6	28794006
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	6.65e-06	24	179	4	32212159
Pubmed	In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.	SP1 POU2F1 NFKB2	7.37e-06	8	179	3	7690421
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RNF169 CAD CDC42BPA MYCBP2 MTMR8 ITGA5 CDC42BPB KMT2D TBC1D4 PTPRK ARVCF SEC24B LRRC1 FBXO33 PHLPP2 COL1A2 RAVER1 NIN	8.86e-06	1049	179	18	27880917
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 POU6F2 CDC42BPA MYCBP2 PPFIA2 FRMPD1 HECTD4 CHD9 E2F3 ZNF236 INTS3 CDC42BPB SBNO2 ITFG1 HIPK3 TBC1D4 ZNF532 LRRC1 NLRC5 RPRD2 MBD5 RAVER1	9.18e-06	1489	179	22	28611215
Pubmed	Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development.	CNOT6 CNOT6L CNOT2	1.10e-05	9	179	3	21741365
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TPR SP1 RNF169 CAD NELFB MED1 WDR43 TBC1D4 RPRD2 TNKS1BP1 BRAT1 RAVER1	1.29e-05	503	179	12	16964243
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	KRT78 SPEF2 CHD9 RYR1 TBC1D4 TLR3 PKHD1 POLQ	1.33e-05	208	179	8	33230847
Pubmed	Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators.	SP1 SP3 PURB	1.57e-05	10	179	3	15282343
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WASL CAD CHERP MED1 DHX9 TBC1D4 RPRD2	1.60e-05	154	179	7	16055720
Pubmed	Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.	LRSAM1 NFKB2 SEC24B TNKS1BP1	2.18e-05	32	179	4	19542561
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PRUNE2 NCOA6 MYCBP2 CDC42BPB URB1 RPRD2 TNKS1BP1 NIN	2.34e-05	225	179	8	12168954
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	KRT1 WASL DISC1 PPFIA2 KIF16B PDE4DIP	2.47e-05	111	179	6	22558309
Pubmed	The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression.	SP1 POU2F1	2.63e-05	2	179	2	8668525
Pubmed	Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure.	SP1 SP3	2.63e-05	2	179	2	10825178
Pubmed	Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).	CHERP RYR1	2.63e-05	2	179	2	21454501
Pubmed	HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.	SP1 SP3	2.63e-05	2	179	2	31299490
Pubmed	Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells.	TLR7 TLR3	2.63e-05	2	179	2	19887600
Pubmed	Type I IFN-mediated synergistic activation of mouse and human DC subsets by TLR agonists.	TLR7 TLR3	2.63e-05	2	179	2	26255864
Pubmed	TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.	TPR NTRK1	2.63e-05	2	179	2	1532241
Pubmed	Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.	SP1 SP3	2.63e-05	2	179	2	25538045
Pubmed	TLR3\TLR7 as Differentially Expressed Markers Among Viral, Nonviral, and Autoimmune Diseases in Egyptian Patients.	TLR7 TLR3	2.63e-05	2	179	2	34342515
Pubmed	Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma.	TLR7 TLR3	2.63e-05	2	179	2	37133342
Pubmed	Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.	TLR7 TLR3	2.63e-05	2	179	2	34161582
Pubmed	Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines.	TLR7 TLR3	2.63e-05	2	179	2	20309865
Pubmed	Cloning and chromosomal localization of human Cdc42-binding protein kinase beta.	CDC42BPA CDC42BPB	2.63e-05	2	179	2	10198171
Pubmed	CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.	CNOT6 CNOT6L	2.63e-05	2	179	2	34788619
Pubmed	Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.	SP1 SP3	2.63e-05	2	179	2	31164147
Pubmed	Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus.	SP1 SP3	2.63e-05	2	179	2	17681019
Pubmed	Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice.	SP1 SP3	2.63e-05	2	179	2	37735515
Pubmed	Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells.	SP1 SP3	2.63e-05	2	179	2	26807725
Pubmed	Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide.	SP1 SP3	2.63e-05	2	179	2	15951564
Pubmed	Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study.	TLR7 TLR3	2.63e-05	2	179	2	35063671
Pubmed	Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice.	TLR7 TLR3	2.63e-05	2	179	2	26581984
Pubmed	Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.	SP1 SP3	2.63e-05	2	179	2	22464952
Pubmed	Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3.	SP1 SP3	2.63e-05	2	179	2	8845379
Pubmed	TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.	TLR7 TLR3	2.63e-05	2	179	2	16105838
Pubmed	Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.	CDC42BPA CDC42BPB	2.63e-05	2	179	2	18263588
Pubmed	Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers.	TLR7 TLR3	2.63e-05	2	179	2	30906301
Pubmed	Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo.	TLR7 TLR3	2.63e-05	2	179	2	16537810
Pubmed	Association of TLR3 gene 1377C/T (rs3775290) and TLR7 gene C/G (rs3853839) polymorphism with hand, foot, and mouth disease caused by human enterovirus 71 infection susceptibility and severity in the Chinese Han population: A meta-analysis of case-control studies.	TLR7 TLR3	2.63e-05	2	179	2	35801751
Pubmed	Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.	SP1 SP3	2.63e-05	2	179	2	21248046
Pubmed	Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.	SP2 SP3	2.63e-05	2	179	2	1341900
Pubmed	Sp1 and Sp3 activate transcription of the human dopamine transporter gene.	SP1 SP3	2.63e-05	2	179	2	15816870
Pubmed	Sp family transcription factors regulate expression of rat D2 dopamine receptor gene.	SP1 SP3	2.63e-05	2	179	2	9628590
Pubmed	The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells.	SP1 SP3	2.63e-05	2	179	2	14608051
Pubmed	Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium.	SP1 SP3	2.63e-05	2	179	2	9329821
Pubmed	Plasmacytoid dendritic cells regulate colitis-associated tumorigenesis by controlling myeloid-derived suppressor cell infiltration.	TLR7 TLR3	2.63e-05	2	179	2	32810576
Pubmed	Tim-3 suppression combined with TLR3 activation enhances antiviral immune response in patients with chronic HCV infection.	HAVCR2 TLR3	2.63e-05	2	179	2	27329385
Pubmed	O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1.	SP1 POU2F1	2.63e-05	2	179	2	19070619
Pubmed	Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.	SP1 SP3	2.63e-05	2	179	2	14766015
Pubmed	U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.	TLR7 TLR3	2.63e-05	2	179	2	16368889
Pubmed	Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.	LRP10 IL7R	2.63e-05	2	179	2	38956225
Pubmed	Upregulation of TLR7 and TLR3 gene expression in the lung of respiratory syncytial virus infected mice.	TLR7 TLR3	2.63e-05	2	179	2	19445181
Pubmed	RNA receptors, TLR3 and TLR7, are potentially associated with SLE clinical features.	TLR7 TLR3	2.63e-05	2	179	2	33650302
Pubmed	The DISC1 promoter: characterization and regulation by FOXP2.	FOXP2 DISC1	2.63e-05	2	179	2	22434823
Pubmed	An Sp1/Sp3 binding polymorphism confers methylation protection.	SP1 SP3	2.63e-05	2	179	2	18725933
Pubmed	Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands.	TLR7 TLR3	2.63e-05	2	179	2	23019335
Pubmed	Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts.	TLR7 TLR3	2.63e-05	2	179	2	27586271
Pubmed	Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells.	SP1 SP3	2.63e-05	2	179	2	19437621
Pubmed	The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.	CNOT6 CNOT6L	2.63e-05	2	179	2	21233283
Pubmed	Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.	TLR7 TLR3	2.63e-05	2	179	2	27046485
Pubmed	Transcriptional control of human CD2AP expression: the role of Sp1 and Sp3.	SP1 SP3	2.63e-05	2	179	2	21604172
Pubmed	Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3.	TLR7 TLR3	2.63e-05	2	179	2	25539593
Pubmed	Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production.	TLR7 TLR3	2.63e-05	2	179	2	27084119
Pubmed	Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.	NCOA6 MED1	2.63e-05	2	179	2	16828057
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TPR NCOA6 CAD EP400 MYCBP2 NSD1 MED1 KMT2D SEC24B CIZ1 RPRD2 TNKS1BP1	3.03e-05	549	179	12	38280479
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SP3 RNF169 CAD UBQLN1 CDC42BPA EP400 NSD1 URB2 MED1 CDC42BPB TRIP4 WDR43 CNOT6 URB1 CNOT6L ACAD11 AP1G1 PURB SEC24B CIZ1 CNOT2	3.19e-05	1497	179	21	31527615
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	NCOA6 KMT2D N4BP2	3.69e-05	13	179	3	17761849
Pubmed	No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.	DISC1 ARVCF STX7	4.68e-05	14	179	3	18198266
Pubmed	Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues.	PGC GRK1 GUCY2D	4.68e-05	14	179	3	37033230
Pubmed	Integral and associated lysosomal membrane proteins.	VASN CLN3 TLR3 ZFYVE26 STX7 ABCC10	5.05e-05	126	179	6	17897319
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	CNOT6 CNOT6L CNOT2	5.83e-05	15	179	3	21981923
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	TPR DCPS BAZ2B URB2 INTS3 WDR43 DHX9 URB1 RPRD2	7.26e-05	340	179	9	29478914
Pubmed	Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts.	SP1 SP3	7.88e-05	3	179	2	18417714
Pubmed	Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.	SP1 SP3	7.88e-05	3	179	2	14701757
Pubmed	Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.	SP1 SP3	7.88e-05	3	179	2	15118068
Pubmed	Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors.	SP1 SP3	7.88e-05	3	179	2	17317039
Pubmed	In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.	SP1 SP3	7.88e-05	3	179	2	11850421
Interaction	CNOT6L interactions	VASN RC3H1 LRSAM1 CNOT6 CNOT6L N4BP2 TLR3 TNKS1BP1 CNOT2 RAVER1	8.17e-09	93	175	10	int:CNOT6L
Interaction	TOP3B interactions	HSPG2 SEMA4B NCOA6 CAD CDC42BPA EP400 MYCBP2 TMEM94 MTMR8 HECTD4 NSD1 ITGA5 ZNF236 CDC42BPB WDR59 RYR1 SBNO2 DHX9 URB1 KMT2D CNOT6L ARVCF CLN3 NFKB2 SEC24B PKP2 NLRC5 ZFYVE26 TNKS1BP1 MBD5 BRAT1 CNOT2 ABCC10	3.93e-07	1470	175	33	int:TOP3B
Interaction	CNOT9 interactions	VASN NTRK1 RC3H1 PCDHA3 CNOT6 CNOT6L N4BP2 RPRD2 TNKS1BP1 CNOT2 RAVER1	5.84e-06	231	175	11	int:CNOT9
Interaction	GADD45B interactions	CNOT6 CNOT6L TNKS1BP1 CNOT2 RAVER1	1.23e-05	35	175	5	int:GADD45B
Interaction	PABPN1L interactions	CNOT6 CNOT6L TNKS1BP1 CNOT2 RAVER1	1.86e-05	38	175	5	int:PABPN1L
Interaction	LGR4 interactions	TPR KRT1 CAD CDC42BPA MYCBP2 CDC42BPB DHX9 HAVCR2 URB1 KRT77 PKHD1	1.91e-05	262	175	11	int:LGR4
Interaction	NANOS1 interactions	CNOT6 CNOT6L TNKS1BP1 CNOT2	2.39e-05	20	175	4	int:NANOS1
Interaction	CNOT7 interactions	RC3H1 CNOT6 CNOT6L N4BP2 PURB TNKS1BP1 CNOT2 RAVER1	3.11e-05	140	175	8	int:CNOT7
Interaction	TOB1 interactions	CNOT6 CNOT6L TNKS1BP1 CNOT2 RAVER1	3.85e-05	44	175	5	int:TOB1
Interaction	SCGN interactions	CNOT6 CNOT6L TNKS1BP1 STX7 CNOT2 RAVER1	4.82e-05	75	175	6	int:SCGN
Interaction	GPC5 interactions	HSPG2 DCPS POU2F1	5.20e-05	9	175	3	int:GPC5
Interaction	NANOS2 interactions	CNOT6 CNOT6L TNKS1BP1 CNOT2	7.07e-05	26	175	4	int:NANOS2
Interaction	FANCD2OS interactions	CNOT6 CNOT6L TNKS1BP1 CNOT2	7.07e-05	26	175	4	int:FANCD2OS
Interaction	RELA interactions	SP1 NCOA6 SP3 POU6F2 UBQLN1 SPATA31A3 NTRK1 NSD1 POU2F1 TRIP4 DHX9 KMT2D AP1G1 NFKB2	9.02e-05	485	175	14	int:RELA
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP1 SP2 SP3	2.33e-05	9	120	3	755
GeneFamily	CCR4-NOT transcription complex	CNOT6 CNOT6L CNOT2	4.53e-05	11	120	3	1023
GeneFamily	Ubiquilin family	UBQLNL UBQLN1	4.31e-04	5	120	2	783
GeneFamily	Ataxins\|Trinucleotide repeat containing	EP400 FOXP2 KMT2D	5.89e-04	25	120	3	775
GeneFamily	NLR family	NLRP11 NLRP2 NLRC5	5.89e-04	25	120	3	666
GeneFamily	Keratins, type II	KRT1 KRT78 KRT77	7.42e-04	27	120	3	609
GeneFamily	Immunoglobulin like domain containing	HSPG2 NTRK1 CCDC141 HMCN2 PTPRK CDON	1.83e-03	193	120	6	594
GeneFamily	CD molecules\|Toll like receptors	TLR7 TLR3	1.90e-03	10	120	2	948
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2B MBD5	2.31e-03	11	120	2	1025
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARVCF PKP2 ARMC6	2.90e-03	43	120	3	409
GeneFamily	Fibronectin type III domain containing	EPHB3 LRRN3 PTPRK IL7R CDON	4.29e-03	160	120	5	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 LRRN3 HMCN2 SIGLEC6 CDON	4.41e-03	161	120	5	593
GeneFamily	BPI fold containing	BPIFA4P BPIFB3	4.93e-03	16	120	2	456
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA10 ITGA5	6.24e-03	18	120	2	1160
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA4B SEMA5B	7.68e-03	20	120	2	736
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	SP1 CHERP RC3H1 HECTD4 POU2F1 INTS3 RPRD2 MBD5	3.79e-07	166	179	8	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|Liver / Manually curated celltypes from each tissue	KRT1 TOP6BL CDC42BPB LRRN3 ACAD11 MINDY1 IL7R	5.00e-06	166	179	7	9afa33b5ad27dc33576be592f9b22d8161366838
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MYCBP2 NSD1 NFKBIZ CHD9 DHX9 NIN	9.12e-06	182	179	7	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA PPFIA2 DCX OTOGL PKHD1 DISP3 DNAH9	9.80e-06	184	179	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD TRARG1 VASN ITGA10 KCNE4 OTOGL COL1A2	9.80e-06	184	179	7	89ae8bf1a6c2d355d279d23a5e24a08d9ec2334e
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MYCBP2 NSD1 NFKBIZ CHD9 DHX9 IL7R	9.80e-06	184	179	7	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA PPFIA2 DCX OTOGL PKHD1 DISP3 DNAH9	9.80e-06	184	179	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA PPFIA2 DCX OTOGL PKHD1 DISP3 DNAH9	9.80e-06	184	179	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD TRARG1 VASN ITGA10 KCNE4 OTOGL COL1A2	9.80e-06	184	179	7	34c84ac9a32eaf96f45b79485119cad65905817d
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MYCBP2 NSD1 NFKBIZ CHD9 DHX9 NIN	1.01e-05	185	179	7	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TPR SP1 SP3 KIF16B HEATR5A MED1 CNOT6	1.05e-05	186	179	7	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	PTBP3 POU2F1 DCX LRRN3 TLE2 PDE4DIP COL1A2	1.21e-05	190	179	7	842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	POU2F1 HEATR5A MED1 LRRC58 CNOT6 PTPRK N4BP2	1.34e-05	193	179	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PCW_07-8.5\|World / Celltypes from embryonic and fetal-stage human lung	PPFIA2 E2F3 PLAG1 CSKMT ZNF669 CDON NIN	1.38e-05	194	179	7	5759c83308df017f1faae248e9b85388e25254f0
ToppCell	BL-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MARCHF10 SPEF2 LRRC49 STMND1 OMG DNAH9 CFAP46	1.43e-05	195	179	7	07a6bcef6af93ed87df455dee624037cb75e011a
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PRUNE2 FMOD ITGA10 LRRN3 HMCN2 PTPRK COL1A2	1.48e-05	196	179	7	24d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MARCHF10 TLR7 GRK1 SEMA5B OTOGL DISP3	3.01e-05	148	179	6	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	droplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRSAM1 COQ8B KCNE4 TBC1D4 LRRC1 BRAT1	3.50e-05	152	179	6	0fda8980b10ce16179dea92301db74d728f41794
ToppCell	10x5'-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	KRT1 HSPG2 CDC42BPA NTRK1 SLC2A10 KISS1	4.82e-05	161	179	6	15ba7e69699558353cfeecdcf1dbc2e147379ed6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFKBIZ DHX9 TBC1D4 CNOT6L TLE2 IL7R	4.99e-05	162	179	6	80317c4253bf8e897782e562f29835f181c65b98
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TOP6BL ALG1L2 STARD9 CSKMT POLQ MINDY1	5.52e-05	165	179	6	76abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 FOXP2 HECTD4 PTPRK ZNF532 ARMC6	5.71e-05	166	179	6	89e2b8453180983533faccb4275867861876d7ee
ToppCell	droplet-Lung-LUNG-30m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OMG CNOT6 NFE2L3 HAVCR2 TBC1D4 PLAG1	6.11e-05	168	179	6	0e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPEF2 FRMPD1 STMND1 CPN2 DNAH9 CFAP46	6.11e-05	168	179	6	fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPEF2 FRMPD1 STMND1 CPN2 DNAH9 CFAP46	6.11e-05	168	179	6	7edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC13A2 LACTBL1 TBC1D4 TRPV4 POLQ BRAT1	6.52e-05	170	179	6	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5_RORB_LINC01202\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	POU6F2 FOXP2 LRRN3 PTPRK OTOGL SIGLEC6	6.52e-05	170	179	6	87cac555f16b6c2ef3d1b3a00f992d8bf2237b50
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9\|TCGA-Bladder / Sample_Type by Project: Shred V9	SEMA4B PTPRK AP1G1 SERPINB3 LRRC1 TNKS1BP1	6.73e-05	171	179	6	adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FOXP2 SLC46A1 TLR7 RYR1 HAVCR2 CFAP46	6.95e-05	172	179	6	9befd44bce43eb5dc1fe3d2e44608f442cf74a47
ToppCell	droplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 HAVCR2 GPR83 TBC1D4 TLR3 LRRC1	7.41e-05	174	179	6	2afa5eea54b67c549c5058ece98296eee3829c11
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	TTLL5 HECTD4 CCDC141 NFE2L3 TBC1D4 PLAG1	8.40e-05	178	179	6	829ea00c022a78d1861aa3ec53503272976775d9
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 HSPG2 MARCHF10 ITGA5 GDF3 HMCN2	8.67e-05	179	179	6	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	KRT1 HSPG2 CDC42BPA NTRK1 SLC2A10 SIGLEC6	8.94e-05	180	179	6	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	3'_v3-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	KRT1 HSPG2 CDC42BPA NTRK1 SLC2A10 SIGLEC6	9.21e-05	181	179	6	30ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCell	Pericytes-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	PRUNE2 VASN LRRN3 KCNE4 SEMA5B COL1A2	9.21e-05	181	179	6	ff445a8e56522e57e27405184d123cf905caf8cc
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TTLL5 HECTD4 CCDC141 NFE2L3 TBC1D4 PLAG1	9.21e-05	181	179	6	9275531e896e118cee043ed94fd31a0070d9581c
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	MARCHF10 SPEF2 STMND1 TRPV4 DNAH9 CFAP46	9.49e-05	182	179	6	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MYCBP2 NSD1 CHD9 DHX9 IL7R	9.49e-05	182	179	6	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MYCBP2 NSD1 CHD9 DHX9 IL7R	9.49e-05	182	179	6	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BAZ2B TOPAZ1 PPFIA2 OTOGL FAM186A PKHD1	1.07e-04	186	179	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILC2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	KRT1 NTRK1 NFKBIZ CCDC141 PKP2 IL7R	1.10e-04	187	179	6	dd5183d2c620b2a87253a9783b70c5df2c36c570
ToppCell	21-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.10e-04	187	179	6	1a2178a195d078d1963947b327c6d0d4f2f48341
ToppCell	Ciliated_cells-B-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.10e-04	187	179	6	bc1f33f332ac939c2425f510173430ca2ba0c3ee
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-F_(Ciliated)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.13e-04	188	179	6	5ba5cbb403518026e9040379fb5d99339ea977d8
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.17e-04	189	179	6	dc440015949a768188c67661b6be63b1ead1a0f0
ToppCell	Epithelial_cells-Ciliated_cells-A\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.20e-04	190	179	6	549d813a8f23b175875e53347928941f143e236c
ToppCell	Ciliated_cells-B\|World / lung cells shred on cell class, cell subclass, sample id	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.20e-04	190	179	6	7031fbedc13be1a00f6333ad6d51849c3739c2e6
ToppCell	Ciliated_cells-A\|World / lung cells shred on cell class, cell subclass, sample id	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.20e-04	190	179	6	cd87731aaa7d252424f79cfce9f7931457f17bdf
ToppCell	Epithelial_cells-Ciliated_cells-B\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.20e-04	190	179	6	426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCell	ASK428-Epithelial-Ciliated\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.24e-04	191	179	6	0c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-3\|TCGA-Ovary / Sample_Type by Project: Shred V9	ITGA5 SBNO2 HAVCR2 KCNE4 IL7R COL1A2	1.24e-04	191	179	6	80d30d8eedb4c70b58440646325bc04c5700803e
ToppCell	control-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KRT1 HSPG2 TCAF1 NTRK1 SIGLEC6 ZFYVE26	1.24e-04	191	179	6	afebdc59a1f884ce3f2f5fe040e16b0e95e4e7c5
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 FMOD NTRK1 KCNE4 CDON COL1A2	1.27e-04	192	179	6	c3707243c5590d852c9f28429c96f50a1fa6b0dc
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 FMOD NTRK1 KCNE4 CDON COL1A2	1.27e-04	192	179	6	f9fb24457999dc9e751a099d7f995543b9330ad4
ToppCell	ASK428-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.27e-04	192	179	6	356ebddd03aec341b79890977edb8ff0804999a1
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	MARCHF10 FOXP2 SPEF2 STMND1 DNAH9 CFAP46	1.27e-04	192	179	6	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B CHD9 TLR7 TLR3 IL7R COL1A2	1.31e-04	193	179	6	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.31e-04	193	179	6	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B CHD9 TLR7 TLR3 IL7R COL1A2	1.31e-04	193	179	6	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	CCDC141 LRRN3 TBC1D4 PTPRK PLAG1 IL7R	1.31e-04	193	179	6	627d345baf1940218c61907305705298e473dbab
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B CHD9 TLR7 TLR3 IL7R COL1A2	1.31e-04	193	179	6	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B CHD9 TLR7 TLR3 IL7R COL1A2	1.31e-04	193	179	6	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	3'_v3-Lung-Mast\|Lung / Manually curated celltypes from each tissue	KRT1 HSPG2 NTRK1 NFKBIZ NFE2L3 SIGLEC6	1.35e-04	194	179	6	5e6eb81ddc9d5e22c1297734689f476d5a05bff6
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MARCHF10 SPEF2 LRRC49 STMND1 DNAH9 CFAP46	1.35e-04	194	179	6	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-J_(Lipofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	NFKBIZ NFE2L3 NFKB2 PKP2 CDON GP1BA	1.35e-04	194	179	6	784b15119c91ace33d34bfb3d68c182566a3e9a8
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CHD9 DHX9 ARVCF N4BP2 IL7R	1.35e-04	194	179	6	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	MARCHF10 FOXP2 SPEF2 STMND1 DNAH9 CFAP46	1.35e-04	194	179	6	958e648138676d46698090b4046cb484083ae449
ToppCell	3'_v3-Lung-Mast-Mast_cells\|Lung / Manually curated celltypes from each tissue	KRT1 HSPG2 NTRK1 NFKBIZ NFE2L3 SIGLEC6	1.35e-04	194	179	6	7b7f1714c4a9d9519c4d0e460cb87f2eb82392dd
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NFE2L3 KCNE4 SEMA5B NFKB2 PKP2 GP1BA	1.35e-04	194	179	6	c45e9d09b5cd6973de6c3f1713b3bf36fa4bfe57
ToppCell	COVID-19-Epithelial-Ciliated_cells\|COVID-19 / Condition, Lineage and Cell class	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.35e-04	194	179	6	43be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	FOXP2 SPEF2 STMND1 PTPRK DNAH9 CFAP46	1.38e-04	195	179	6	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FOXP2 NFKBIZ CHD9 TOP6BL HMCN2 COL1A2	1.38e-04	195	179	6	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.42e-04	196	179	6	686a5a0ddb00929842c1c98445c59edfcc9a8a04
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.42e-04	196	179	6	67aefc480714e4b8c9ae53c036efdc07ec6f94af
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.42e-04	196	179	6	ca56311edc6788e032e7635fa69b1e07035202b5
ToppCell	Severe_COVID-19-Epithelial-Ciliated\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.42e-04	196	179	6	1cdef976a754c90d18b6149d367bd64e6e99b0a9
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.42e-04	196	179	6	69f5081e06d84ec1d9695762df801a9d0df1984b
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MARCHF10 SPEF2 LRRC49 STMND1 DNAH9 CFAP46	1.46e-04	197	179	6	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHB3 FOXP2 SLC13A2 CCDC141 ACSL5 CDON	1.46e-04	197	179	6	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PTBP3 SEMA4B FOXP2 TOP6BL PKHD1	1.46e-04	197	179	6	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / Treatment groups by lineage, cell group, cell type	HSPG2 DISC1 RC3H1 CDC42BPB RYR1 POLQ	1.46e-04	197	179	6	038fd92750257d43d5e980fd06d77742b543f11a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FMOD NTRK1 ITGA10 ITIH2 PKP2 COL1A2	1.55e-04	199	179	6	dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell	356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NFKBIZ NFE2L3 NFKB2 PKP2 CDON GP1BA	1.55e-04	199	179	6	f4fdf94c561dca35bb17766d908c5030655f43eb
ToppCell	Sepsis-Leuk-UTI-Myeloid-tDC\|Leuk-UTI / Disease, condition lineage and cell class	DCPS ACAD11 SIGLEC6 TLR3 SERPINF2 POLQ	1.55e-04	199	179	6	a2f154b15087803958a656d2a41b6d83fd37b32f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FMOD NTRK1 ITGA10 ITIH2 PKP2 COL1A2	1.55e-04	199	179	6	c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 NFKBIZ TOP6BL SLC9A2 PKHD1 TRPV4	1.55e-04	199	179	6	3cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCell	356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NFKBIZ NFE2L3 NFKB2 PKP2 CDON GP1BA	1.55e-04	199	179	6	c0fe99ed906d0eb99cccdab9a1fa32c17b3542e7
ToppCell	Biopsy_Control_(H.)-Epithelial-Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.59e-04	200	179	6	9ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.59e-04	200	179	6	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.59e-04	200	179	6	31d75c26055177d656df1fbb10b764cebd61e122
ToppCell	Biopsy_Other_PF-Epithelial-Ciliated\|Biopsy_Other_PF / Sample group, Lineage and Cell type	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.59e-04	200	179	6	721371698bce8890853fb6b6b01a2c20293b39e9
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MARCHF10 SPEF2 STMND1 TRPV4 DNAH9 CFAP46	1.59e-04	200	179	6	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	DISC1 NFKBIZ ITGA5 NFKB2 ACSL5 COL1A2	1.59e-04	200	179	6	25f4c051c2e869481f33c22ad54de97efac444ad
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MARCHF10 SPEF2 STMND1 OMG DNAH9 CFAP46	1.59e-04	200	179	6	e1dce91c6c531bb212002a14705e496d77ad3490
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBQLN1 CDC42BPA LRRC58 OMG ITFG1 LRP10	1.59e-04	200	179	6	f0c338877e39226a90c4effe12f6501d33542a73
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MARCHF10 SPEF2 STMND1 TRPV4 DNAH9 CFAP46	1.59e-04	200	179	6	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	DISC1 NFKBIZ ITGA5 NFKB2 ACSL5 COL1A2	1.59e-04	200	179	6	da45a85a4667965b24ba824af871157af5b4cd19
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU6F2 ITGA5 CCDC141 NFE2L3 LRRC1	1.87e-04	131	179	5	80630812f8894b9358d36dc2dd03fea7ee870502
Drug	Loxapine succinate [27833-64-3]; Up 200; 9uM; PC3; HT_HG-U133A	SP1 HSPG2 WASL DISC1 WDR59 HIPK3 URB1 TLE2 NFKB2 PDE4DIP	1.74e-06	189	171	10	6694_UP
Disease	neutrophil count	PRUNE2 SP1 CDC42BPA DCPS MYCBP2 NTRK1 RC3H1 HECTD4 NSD1 POU2F1 CHD9 PCDHA3 NHLRC2 PGC SBNO2 RRAGC LRP10 ARVCF FAM186A NLRC5 RPRD2	5.39e-05	1382	171	21	EFO_0004833
Disease	Lymphohistiocytosis, Hemophagocytic	RC3H1 HAVCR2	9.98e-05	3	171	2	C0024291
Disease	interleukin-7 receptor subunit alpha measurement	SPEF2 IL7R	1.99e-04	4	171	2	EFO_0020508
Disease	creatinine measurement	SLC7A13 PPFIA2 NSD1 CHD9 E2F3 MED1 RYR1 SBNO2 SLC9A2 NFE2L1 PKHD1 TRPV4 MBD5 MINDY1 ABCC10	7.15e-04	995	171	15	EFO_0004518
Disease	Hereditary Motor and Sensory Neuropathy Type I	LRSAM1 TRPV4	9.14e-04	8	171	2	C0751036
Disease	Roussy-Levy Syndrome (disorder)	LRSAM1 TRPV4	9.14e-04	8	171	2	C0205713
Disease	Charcot-Marie-Tooth Disease, Type Ib	LRSAM1 TRPV4	9.14e-04	8	171	2	C0270912
Disease	Charcot-Marie-Tooth Disease, Type Ia (disorder)	LRSAM1 TRPV4	9.14e-04	8	171	2	C0270911
Disease	nasal disorder	SPEF2 FBXO33 IL7R	1.09e-03	35	171	3	MONDO_0002436
Disease	Russell-Silver syndrome	FOXP2 PLAG1	1.46e-03	10	171	2	C0175693
Disease	Malignant neoplasm of breast	NCOA6 FRMPD1 MTMR8 KIF16B POU2F1 SLC2A10 SLC9A2 KMT2D ZNF532 SEMA5B OTOGL N4BP2 NLRC5 ZFYVE26 DNAH9	1.53e-03	1074	171	15	C0006142
Disease	cerebral cavernous malformation (implicated_via_orthology)	CDC42BPA CDC42BPB	1.77e-03	11	171	2	DOID:0060669 (implicated_via_orthology)
Disease	guanosine diphosphate measurement	BAZ2B TBC1D4	1.77e-03	11	171	2	EFO_0010494
Disease	atopic dermatitis (implicated_via_orthology)	WASL NFKBIZ	1.77e-03	11	171	2	DOID:3310 (implicated_via_orthology)
Disease	intracranial aneurysm (is_implicated_in)	KMT2D COL1A2	2.12e-03	12	171	2	DOID:10941 (is_implicated_in)
Disease	Charcot-Marie-Tooth Disease	LRSAM1 TRPV4	2.12e-03	12	171	2	C0007959
Disease	colon carcinoma (is_marker_for)	KMT2D TLR3	2.50e-03	13	171	2	DOID:1520 (is_marker_for)
Disease	Hereditary Motor and Sensory-Neuropathy Type II	LRSAM1 TRPV4	2.50e-03	13	171	2	C0270914
Disease	Lymphoma, Follicular, Grade 2	RRAGC KMT2D	3.34e-03	15	171	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	RRAGC KMT2D	3.34e-03	15	171	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	RRAGC KMT2D	3.34e-03	15	171	2	C1956130
Disease	Lymphoma, Large-Cell, Follicular	RRAGC KMT2D	3.34e-03	15	171	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	RRAGC KMT2D	3.34e-03	15	171	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	RRAGC KMT2D	3.34e-03	15	171	2	C0079758
Disease	waist circumference	SUPT20HL1 DISC1 HECTD4 KCNE4 PTPRK N4BP2 PKHD1 FBXO33	3.68e-03	429	171	8	EFO_0004342
Disease	Spondyloepiphyseal Dysplasia	HSPG2 TRPV4	3.80e-03	16	171	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	HSPG2 TRPV4	3.80e-03	16	171	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	HSPG2 TRPV4	3.80e-03	16	171	2	C4551479
Disease	autism spectrum disorder (is_implicated_in)	FOXP2 MBD5	3.80e-03	16	171	2	DOID:0060041 (is_implicated_in)
Disease	Schwartz-Jampel Syndrome	HSPG2 TRPV4	3.80e-03	16	171	2	C0036391
Disease	Melnick-Needles Syndrome	HSPG2 TRPV4	3.80e-03	16	171	2	C0025237
Disease	major depressive disorder (is_implicated_in)	FOXP2 DISC1	4.29e-03	17	171	2	DOID:1470 (is_implicated_in)
Disease	Van Buchem disease	HSPG2 TRPV4	4.29e-03	17	171	2	C0432272
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR7 TLR3	4.29e-03	17	171	2	DOID:8677 (biomarker_via_orthology)
Disease	Osteochondrodysplasias	HSPG2 TRPV4	5.35e-03	19	171	2	C0029422
Disease	Dyschondroplasias	HSPG2 TRPV4	5.35e-03	19	171	2	C0013366

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGQEAPAALSELLQQ	URB2	1076	Q14146
TAGQPLQLQGSVLQI	EP400	1646	Q96L91
LSQGTGPQELVTQAL	BRAT1	436	Q6PJG6
NSLVGEPILQNVLGS	BPIFB3	41	P59826
FLQQQLQALPEGSVL	DISP3	1146	Q9P2K9
QTLKLSNNALSGLPQ	CPN2	196	P22792
QLVLQEQSPGSQASL	ARVCF	66	O00192
LSQLGLQELFQAPDL	SERPINF2	351	P08697
FEQLTLDGQNLPSLV	ALG1L2	86	C9J202
PNLSVLQEGLLNIGD	BAZ2B	1116	Q9UIF8
LQSLNALSVLTDGQP	ARMC6	156	Q6NXE6
QGLLSLQDLQNVNTP	CFAP46	1851	Q8IYW2
QLLTGSPELQLQFSN	DCPS	96	Q96C86
PLVGQLSLGQLQEVS	DISC1	506	Q9NRI5
ANIVQPLAETGLQLS	ACAD11	341	Q709F0
LLAQGNQIALLDSPT	KIF16B	386	Q96L93
ALQNNLLSPLLTGTE	NFE2L1	291	Q14494
VPNGSALTQENISLL	RC3H1	1086	Q5TC82
LQLLNNLGPSASLQL	RAVER1	331	Q8IY67
LNQLPSVTLDAVLQG	NSD1	1056	Q96L73
GQPLVVLQGNNIILE	HSPG2	1026	P98160
FQGLTIPQGSSLVLQ	RIMBP3B	1546	A6NNM3
ALSPQFTGILQLLQS	INTS3	281	Q68E01
PTSQANDLLDLLGGN	AP1G1	621	O43747
LSPLQLQSLQQALDG	OTOA	1091	Q7RTW8
QLLQSSQQGVPASLG	ABCC10	1476	Q5T3U5
QGLSLQELVLSGNPL	NTRK1	136	P04629
NPSALLGSIIQILNN	OR10D4P	261	Q8NGN7
LANFALVLQGPLTTQ	SLC46A1	31	Q96NT5
LLENAPNGTLVVTVN	PCDHA3	251	Q9Y5H8
VPNNALEGLENLTAL	FMOD	191	Q06828
DLGIQNLGQTVSLAP	KCNE4	31	Q8WWG9
QENGLSSLPSEIQLL	LRRD1	196	A4D1F6
PNDNSVLGNLRSLLQ	LRP10	516	Q7Z4F1
PNQSLVSLLGDQRES	NFKBIZ	336	Q9BYH8
EANNLGLLDPNSVSL	ITIH2	401	P19823
SDLNLQQVSPLFGTI	GUCY2D	336	Q02846
LLLEAISQTNPGSQF	MTMR8	221	Q96EF0
NQLTALPDDLGQLTA	LRSAM1	91	Q6UWE0
VGLPLTGLNTQTQQL	NLRP11	951	P59045
LGLVLFQQLTGQPNV	SLC2A10	236	O95528
LSQSLEQGPSLQLEA	HMCN2	3456	Q8NDA2
QPLLSSLSNLAEQLQ	C1orf109	36	Q9NX04
LDNNIPGNSTLITAV	FBXO33	286	Q7Z6M2
QLTLAQLGLDLGPNS	GDF3	121	Q9NR23
GIQEVTINQSLLQPL	KRT1	151	P04264
QGLLLPLLQEAQAAS	CSKMT	61	A8MUP2
ENNQISLTLSGPLQG	FAM205A	121	Q6ZU69
NPGLINNASSGLLQA	FOXP2	626	O15409
FQLLSSQPENSLEGI	NFE2L3	266	Q9Y4A8
EQFQTENGVLLPSLQ	NELFB	31	Q8WX92
QQLESLGLLAPGEQS	KISS1	36	Q15726
GPLGLTDLELAQQLQ	MINDY1	406	Q8N5J2
GGIQEVTINQNLLTP	KRT78	81	Q8N1N4
PLDSGLNNALQGLSV	LRRC49	391	Q8IUZ0
QQLQEQLPLIVGSAT	EPHB3	551	P54753
LQSGILTLNPVAQGQ	IL7R	421	P16871
NQSLVTLDLGQNPLG	NLRP2	981	Q9NX02
LLSIQGDGQPLNLVN	CDC42BPB	1396	Q9Y5S2
LSKEQINSQTPGNLL	HECTD4	3281	Q9Y4D8
LANNLLPTSQLQSGK	GPR83	396	Q9NYM4
ISQTQGLPGEQLLNV	HIPK3	411	Q9H422
LLNDLQPLQNELSLG	OOSP4A	41	A0A2R8YFL7
ILFSQPLQITDTQQG	NHLRC2	701	Q8NBF2
QTLSLGGNQLQSIPA	LRRC58	146	Q96CX6
GGNQLQSIPAEIENL	LRRC58	151	Q96CX6
NDISLQSLPENIGNL	LRRC1	136	Q9BTT6
QLLPGLGALQSLNLS	NLRC5	1026	Q86WI3
QLPQLSLLQLSQTGL	NLRC5	1161	Q86WI3
LSSLGSLENPQENVV	MVB12A	56	Q96EY5
GLTLTPAQQQLLLQQ	POU2F1	111	P14859
LSQLLDNSGAPNVTI	NCOA6	1491	Q14686
ELINQGPSSISQGVL	ITGA5	831	P08648
LLEQGLETQNPTQVG	COG5	246	Q9UP83
SLNNQIETLLTPEGS	COL1A2	1141	P08123
IQPTLGANGVILDNQ	CHD9	2411	Q3L8U1
LNALITTLGPELQGN	HEATR5A	1001	Q86XA9
NNPLGLASAEQQGLI	LACTBL1	116	A8MY62
LQLAESQPNLLEIGS	CCDC141	41	Q6ZP82
IQLLSQSPDGVLDLN	E2F3	191	O00716
SIIQQLQSPALGLGQ	CHERP	276	Q8IWX8
PGLNNVSQGDTLELQ	FRMPD1	1031	Q5SYB0
LQLSQDGLQLTPASS	POLQ	1806	O75417
LPSGNLQILNVSLED	CDON	171	Q4KMG0
DLTRSLSDNINLPQG	DCX	86	O43602
QPVLPLLDLNNQSVG	ACSL5	36	Q9ULC5
PGIAQSIQSDVQNLL	COQ8B	241	Q96D53
LANNNLTELPAGLLN	GP1BA	171	P07359
DLLLNPQGNLSLVDS	MARCHF10	561	Q8NA82
QNLLNILQPSAGEGD	MBD5	936	Q9P267
LVGQQSLLTLQGTLQ	ITGA10	526	O75578
DLLDILSNGTAPQQV	DNAH9	1611	Q9NYC9
ALGITLTLQQAQQLG	FAM186A	1226	A6NE01
IQDGLFQPLLQATLA	GRK1	141	Q15835
FQTQLPSLGAGLLQS	SEC24B	811	O95487
LQGLSSLLQSVTGNP	RPRD2	536	Q5VT52
TLTGTAPNLVLQGQI	SLC13A2	236	Q13183
TENLLPGRELLLQTN	RYR1	621	P21817
QLQTLGLKGNPLTQD	CNOT6	121	Q9ULM6
NTGPDNNLDVVISLL	DHX9	981	Q08211
NPILTSLLQITGNGG	MED1	601	Q15648
LQSGQTIALPAQGLI	PURB	166	Q96QR8
QLNSALPQDIESLTG	PPFIA2	76	O75334
NGISLTLPQTIGQIF	OTOGL	201	Q3ZCN5
QLNANSIIGDGPIIL	PTPRK	311	Q15262
QFLLLGISESPEQQQ	OR1D4	11	P47884
LEPTLNLLGVQFDQN	SPEF2	66	Q9C093
PTLENLLNIFISNSG	RRAGC	241	Q9HB90
LSLLGSAQVPQQGVQ	SUPT20HL1	701	Q3ZLR7
PNINLSLDQSEGSIL	PRUNE2	2806	Q8WUY3
NEPTLNLGNGIALLV	TOP6BL	161	Q8N6T0
GNLLLNPFGISITSQ	TCAF1	381	Q9Y4C2
PVNLTGLDLSQNNLS	LRRN3	91	Q9H3W5
APVLQQTLLQDNLLG	NIN	46	Q8N4C6
FQGLTIPQGSSLVLQ	RIMBP3	1546	Q9UFD9
EIQRTLNQLGTPQDS	STX7	31	O15400
LPTANLTNIQGLVAA	POU6F2	141	P78424
ITPQLLTNAQGQIIA	POU6F2	371	P78424
ETQTLGSLPDINLTQ	HAVCR2	161	Q8TDQ0
LGQILGETPQNLSRD	SPATA31A7	671	Q8IWB4
IFSSGQPVQNLLLDT	SEMA4B	491	Q9NPR2
LSQQDLNQLVLSQPG	SATL1	491	Q86VE3
LQNTSSLPVLEGQAL	SIGLEC6	256	O43699
PNIGRQSQLEALDSL	SBNO2	1096	Q9Y2G9
LEALEGNLPLQIQSN	MYCBP2	2221	O75592
LQLLNVEIQNFGSPL	PKHD1	2986	P08F94
ASNPIIGVLLSTQNN	RNF169	321	Q8NCN4
QIPLQVGAQNLSLSV	STARD9	4196	Q9P2P6
VPLQGLANNVLSGQT	SP1	236	P08047
PLNNEGSLNLLGLET	CDC42BPA	1491	Q5VT25
NLIPEGNIGSNTTLV	SERPINB3	161	P29508
GVLQLLAASAPILQN	URB1	1051	O60287
LAASAPILQNIGQLG	URB1	1056	O60287
IVDLSNNSLTQILPG	OMG	171	P23515
NNSLTQILPGTLINL	OMG	176	P23515
QSDILQTPDGGQLLL	ABHD1	91	Q96SE0
GLTQAGLSPQQTLLS	CLN3	201	Q13286
EQTLELIGTNINGNP	C12orf29	191	Q8N999
QPLLNLQGTNSASLL	CIZ1	66	Q9ULV3
QLNVINGILFIPLSQ	CLUH	1236	O75153
QLQTLGLKGNPLSQD	CNOT6L	126	Q96LI5
DLTTLGLNLNSPENL	CNOT2	381	Q9NZN8
QDLQDPANTIGLGSL	PLAG1	461	Q6DJT9
LGQILGETPQNLSRD	SPATA31A3	671	Q5VYP0
NLNLLPQGAQATSEL	ZNF532	526	Q9HCE3
ALSQGEIPSSLQLVN	nan	96	Q6ZQY7
IDLGLNNLNTLPASV	TLR3	591	O15455
LGVEEINNSTALLPN	TAS1R1	81	Q7RTX1
NSIQNLPSLTFIING	PGC	311	P20142
DLPSQIGNLLNLQTL	PHLPP2	336	Q6ZVD8
PEELGNLQQLSSLGI	PHLPP2	361	Q6ZVD8
LGQILGETPQNLSRD	SPATA31A1	671	Q5TZJ5
LGQILGETPQNLSRD	SPATA31A5	671	Q5VU36
GLLQQPLLSKDQSGS	SLC9A2	761	Q9UBY0
SDGLSPLQLSGQLNS	TMEM94	1046	Q12767
GQNLLLTNLQTIQGI	TPR	811	P12270
ETSQSLQIDLGPLQS	TPR	1911	P12270
LQIDLGPLQSDQQTT	TPR	1916	P12270
NLTISGLSPTQIQLQ	SP2	471	Q02086
SSQIQIIPGSNQTLL	SP3	201	Q02447
IQQGLQTLATEAPGL	UBQLN1	466	Q9UMX0
SLAALPQGQGSQLAL	TNKS1BP1	446	Q9C0C2
LASQEGQLPLLFNTL	SLC7A13	316	Q8TCU3
FSQLALDPSGNQLIV	SEMA5B	126	Q9P283
ALLAGQVLEQVQSSP	UBQLNL	296	Q8IYU4
GQPVLENLSQSIQLS	TLR7	936	Q9NYK1
GNSVLLVTNLNPDLI	PTBP3	356	O95758
SVQLGPGQLSLFNLL	TBC1D4	981	O60343
LLINPNIATVQTSQG	CAD	431	P27708
PGLQLLDLSQNQIAS	VASN	76	Q6EMK4
LDLSQNQIASLPSGV	VASN	81	Q6EMK4
GLPQTLQQEFSLINV	WDR59	386	Q6PJI9
PLNLSGRQEDTILNT	TOPAZ1	1036	Q8N9V7
DQNLLQPGLVGQAIL	ZNF236	1321	Q9UL36
DPSILQQTLQQGNLL	ZNF236	1391	Q9UL36
TLNITSQGQQFPALL	ZNF236	1586	Q9UL36
SDLVTNGLINKPQSL	STMND1	86	H3BQB6
TLSGPLDLEQNSQGL	TRARG1	46	Q8IXB3
ETIQAIANGTLNQPL	TRIP4	351	Q15650
NVGSLLLTPQENESL	WASL	16	O00401
IFGITNESNQPQILL	ITFG1	171	Q8TB96
NESNQPQILLGGNLS	ITFG1	176	Q8TB96
PEQIASVGLLSSNIQ	ZNF419	111	Q96HQ0
GELNSLIGQQLQPLS	TLE2	116	Q04725
VGNPFVLLQQSSSQL	ZFYVE26	1181	Q68DK2
VLGQQILGQLDSSSL	PKP2	16	Q99959
NLSNGRNDTIPVLLD	TRPV4	201	Q9HBA0
AEGQLNGLQSSLNPA	TTLL5	1251	Q6EMB2
SQIPNLDLNENISTG	ZNF669	171	Q96BR6
DLQTNSFPVLLTQGL	WDR43	456	Q15061
QVNTSTGTNNLEPLL	KRT77	201	Q7Z794
GLLNQSRTLLSPQQQ	KMT2D	3976	O14686
GVSSQLLNDLTQGLL	BPIFA4P	26	Q86YQ2
ENLENSGSTLSLNPL	N4BP2	201	Q86UW6
GTSPAQQQVALLDLQ	PDE4DIP	331	Q5VU43
PGLSLGDTALQNLEQ	NFKB2	766	Q00653