Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

8.63e-085423GO:0030156
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

2.22e-0528413GO:0002177
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

1.13e-0519333MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

1.55e-0521333MP:0008893
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B

1.49e-0444333MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B

1.59e-0445333MP:0009376
MousePhenoabnormal heart ventricle wall thickness

ELOA MED1 CBL SCMH1 CDK13

1.77e-04227335MP:0020135
MousePhenodelayed brain development

ELOA CDK13

2.93e-0411332MP:0001889
MousePhenothin ventricular wall

ELOA MED1 SCMH1 CDK13

2.98e-04138334MP:0000280
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

3.05e-0456333MP:0009237
MousePhenoabnormal liver development

ELOA MED1 CDK13

3.39e-0458333MP:0000596
DomainUBA-like

USP25 TAB2 CBL

3.73e-0464413IPR009060
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B

6.66e-0478413PF14604
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

8.85e-0486413IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

8.85e-0486413PF07653
DomainZF_RING_1

NHLRC1 CBL DTX1 MSL2

3.71e-03291414PS00518
DomainZF_RING_2

NHLRC1 CBL DTX1 MSL2

4.04e-03298414PS50089
DomainZnf_RING

NHLRC1 CBL DTX1 MSL2

5.55e-03326414IPR001841
DomainFN3

RIMBP3 RIMBP3C RIMBP3B

9.43e-03199413PS50853
DomainSAM_1

SCMH1 PPFIA4

9.77e-0368412PF00536
DomainFN3_dom

RIMBP3 RIMBP3C RIMBP3B

1.08e-02209413IPR003961
DomainSH3

RIMBP3 RIMBP3C RIMBP3B

1.18e-02216413PS50002
DomainSH3

RIMBP3 RIMBP3C RIMBP3B

1.18e-02216413SM00326
DomainSH3_domain

RIMBP3 RIMBP3C RIMBP3B

1.24e-02220413IPR001452
DomainEF-hand_7

DGKB PPP2R3A

1.50e-0285412PF13499
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

9.24e-09447319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

2.31e-08547317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

8.33e-071447317662146
Pubmed

TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.

MKI67 TAB2

1.79e-06247212556483
Pubmed

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13.

MKI67 CDK13

2.67e-05647231440507
Pubmed

Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis.

MKI67 CDK13

7.99e-051047238511331
Pubmed

Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region.

TAB2 TM9SF2

1.61e-041447212433684
Pubmed

Cell-fate transition and determination analysis of mouse male germ cells throughout development.

MKI67 ZXDC

1.61e-041447234824237
Pubmed

The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.

MKI67 RPL18

1.86e-041547232299058
Pubmed

Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.

MKI67 ELOA

2.40e-041747217170753
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

PPP2R3A CPLANE1 SPTY2D1 OR10AD1 RPL18

2.85e-0443147533660365
Pubmed

Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.

ELOA MED1

3.01e-041947219766566
Pubmed

TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb.

MKI67 SEMA7A

3.01e-041947237686246
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

CAB39 ELOA CPOX MED1 CLSPN CDK13 RPL18 MSL2

3.67e-04132747832694731
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

MKI67 ELOA CDK13 SPTY2D1 RPL18

4.80e-0448347536912080
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

MKI67 ELOA MED1 CDK13 SPTY2D1 RPL18

5.31e-0475947635915203
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

MKI67 MED1 CBL CDK13 RPL18

5.77e-0450347516964243
Pubmed

Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice.

MKI67 SEMA7A

6.61e-042847235666215
Pubmed

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.

MKI67 DGKB

6.61e-042847238324473
Pubmed

Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.

MKI67 SCMH1

7.59e-043047237158107
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

RIMBP3 TAB2 PPP2R3A MLXIP CPLANE1 MTUS1

9.75e-0485347628718761
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

MKI67 SEMA7A DTX1 PPFIA4

1.02e-0332947417474147
Pubmed

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

ELOA MTUS1 CDK13

1.09e-0314947322664934
Pubmed

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.

MKI67 PPFIA4

1.22e-033847238346162
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

2.06e-0411147322q11.21
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRK1 CPLANE1 MTUS1 MSL2

2.95e-05168474d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCelldroplet-Spleen-SPLEEN-30m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MKI67 CPOX CLSPN MTUS1

3.24e-0517247402cc4a9fb7902c572cee37ba828749db4913ee87
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MKI67 NHLRC1 LRRK1 CLSPN

3.31e-0517347420889aa85e36ad3bafdb91b91e43964493c949f9
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RCSD1 LRRK1 ZBBX GABRA5

3.31e-051734745aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MKI67 NHLRC1 LRRK1 CLSPN

3.31e-0517347446e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MKI67 CLSPN SEMA7A RPL18

3.95e-051814749fce5eee75684a7ecac6996e26e9215bc95098b2
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MKI67 CLSPN SEMA7A RPL18

3.95e-05181474ad97e802e934738ddece675232a72308db2da256
ToppCell10x5'-bone_marrow-Lymphocytic_B-Pre-B|bone_marrow / Manually curated celltypes from each tissue

RCSD1 LRRK1 SCMH1 DTX1

4.03e-05182474a5fd392178c2f533e265d2e3ce63b90c2553e4c1
ToppCell343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MKI67 CLSPN SEMA7A SCMH1

4.12e-05183474f03d87b556a3d50360d4eb6126b3466fe7266677
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RCSD1 CDK13 DTX1 SETBP1

4.77e-05190474a7498fe55b7810c482291db782dc5282675d246a
ToppCell10x5'v1-week_12-13-Lymphocytic_B-B_lineage-pro_B_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RCSD1 MLXIP SCMH1 DTX1

4.87e-05191474054fa0493b00149313c243d39cf39a264044f074
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAB39 RCSD1 TM9SF2 CDK13

4.97e-051924741ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-pro_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

RCSD1 MLXIP CDK13 DTX1

5.17e-05194474f64da5f62e29253d60b9546edf734ba5c17daae1
ToppCellNS-critical-LOC-Lymphoid-B_cell|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RCSD1 SEMA7A SETBP1 RPL18

5.27e-051954741c0d8dbe8490c35903061469e395b218416b1aa2
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-pro_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

RCSD1 MLXIP SCMH1 CDK13

5.27e-05195474dc84a910b6f6eb9994cd683aa4fd813a82198e5f
ToppCell10x3'2.3-week_17-19-Lymphocytic_B|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RCSD1 MLXIP CDK13 DTX1

5.60e-051984745f465cf5c7493e32d9afe9e9d05757d0a95acc33
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RCSD1 MLXIP CDK13 DTX1

5.60e-0519847477ce3fe1ab161c0faf8987e73a64ab61294b9255
DiseaseMyelomonocytic leukemia

CBL SETBP1

2.07e-055432C0027019
DiseaseParoxysmal atrial fibrillation

DGKB PPP2R3A SCMH1 PPFIA4

7.90e-05156434C0235480
DiseasePersistent atrial fibrillation

DGKB PPP2R3A SCMH1 PPFIA4

7.90e-05156434C2585653
Diseasefamilial atrial fibrillation

DGKB PPP2R3A SCMH1 PPFIA4

7.90e-05156434C3468561
DiseaseAtrial Fibrillation

DGKB PPP2R3A SCMH1 PPFIA4

8.71e-05160434C0004238
Diseaseatrial fibrillation

DGKB TAB2 PPP2R3A SCMH1 PPFIA4

1.99e-04371435EFO_0000275
DiseaseJuvenile Myelomonocytic Leukemia

CBL SETBP1

3.49e-0419432C0349639
Diseasecongestive heart failure (is_implicated_in)

SLC9A1 CBL

7.11e-0427432DOID:6000 (is_implicated_in)
Diseasehyperthyroidism (biomarker_via_orthology)

CAB39 SLC9A1

7.65e-0428432DOID:7998 (biomarker_via_orthology)
Diseasevaline measurement

PPP2R3A MLXIP

1.56e-0340432EFO_0009792
Diseasesystemic lupus erythematosus (is_marker_for)

MKI67 TAB2

2.15e-0347432DOID:9074 (is_marker_for)
Diseasehair morphology measurement

CPOX MLXIP

2.83e-0354432EFO_0007821
Diseaseblood urea nitrogen measurement

GON4L PPP2R3A MLXIP SETBP1

4.18e-03452434EFO_0004741
DiseaseMYELODYSPLASTIC SYNDROME

CBL SETBP1

4.32e-0367432C3463824

Protein segments in the cluster

PeptideGeneStartEntry
SKHGPGHETPMTIPE

ACSBG2

41

Q5FVE4
FTFHLMSKPTPEKPE

ERICH6B

426

Q5W0A0
KSVPGITSTPHPMDH

AKAP2

11

Q9Y2D5
GIISMSHHAKPKPGV

GVQW3

156

Q3ZCU0
PKSPGLKAMVSPFHS

RCSD1

106

Q6JBY9
MPFPFGKSHKSPADI

CAB39

1

Q9Y376
TSAGSFTPHPKPNKM

CCDC180

1341

Q9P1Z9
GPESTHPLPAKMHNY

CDK13

1446

Q14004
HMGTSKSPAPGFIHL

RIMBP3B

1316

A6NNM3
HMGTSKSPAPGFIHL

RIMBP3C

1316

A6NJZ7
MNPHSTHGPDKDKPF

OR10AD1

261

Q8NGE0
TGFPPVHPLMHLAAK

NMS

86

Q5H8A3
AHVHLMKTPPKGPSR

MTUS1

851

Q9ULD2
PSKPGLDTHGMRHPT

LRRK1

996

Q38SD2
APPKKIMPEAHSHYL

PPFIA4

1161

O75335
AHSGPMRPLPKKHVE

FAM157A

11

C9JC47
SPSKSKDPAHVPMLA

FAM205A

1031

Q6ZU69
HITMDAEKHPPSKDP

FAM221B

11

A6H8Z2
AHSGPMRPLPKKHVE

FAM157C

11

P0CG43
THPHLPTHPMMSKET

GOLGA6L1

41

Q8N7Z2
AFTTGKMSHPPNIPK

GABRA5

376

P31644
TPSAGKAMHTPKPAV

MKI67

1531

P46013
LIPPTTGFMKHTPTK

ODF3

31

Q96PU9
EKIPSHHFMPGSPTK

MSL2

436

Q9HCI7
FPEHATHLKKCPTPM

PPP2R3A

451

Q06190
TQPPGKMEFHLIPHS

DTX1

481

Q86Y01
KMEFHLIPHSLPGFP

DTX1

486

Q86Y01
HFMVSSPHREHPPKK

MLXIP

81

Q9HAP2
AHSGPMRPLPKKHVE

FAM157B

11

P0CG42
KGMIEAFSHPGHTTP

CPLANE1

1966

Q9H799
KIKPAPYPMGSSHAS

ELOA

721

Q14241
KASPCMKPAPVIHHP

GON4L

1126

Q3T8J9
FPHSSPMVKSKPALL

DGKB

91

Q9Y6T7
HHLSPHPPGTVDKKM

CBL

41

P22681
MGVSSVIHPKNPHAP

CPOX

241

P36551
EFPVPKPMVTHGLSH

NHLRC1

351

Q6VVB1
HHTPPPVSSMAGNTK

MED1

626

Q15648
VSMGPAFIHHHPPKS

TAB2

426

Q9NYJ8
HMGTSKSPAPGFIHL

RIMBP3

1316

Q9UFD9
SGDRHPSSKGMPLPH

SPTY2D1

246

Q68D10
HKEPPSPSHNFFKMG

SCMH1

156

Q96GD3
KRGPSFMTSPSPKHL

CLSPN

1306

Q9HAW4
KIKEGKMSPPHFHAS

ZXDC

746

Q2QGD7
HFGKAPGTPHSHTKP

RPL18

151

Q07020
SMEIKSFHEPPKLPS

USP25

1016

Q9UHP3
HSVTDHGMKPRKAFP

SLC9A1

76

P19634
VEPMGPLKTPLFHSK

SEMA7A

391

O75326
KHTHIDKPDCSGPPM

TM9SF2

241

Q99805
MFQSSGVQHHPPEPK

STARD7

111

Q9NQZ5
PPPQFHTNSHVKMSG

SETBP1

1091

Q9Y6X0
KMLPDTFPHPHETTG

ZBBX

336

A8MT70