Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RGPD2 RANBP2 RGPD3	1.39e-05	20	151	4	GO:0061665
GeneOntologyMolecularFunction	complement component C3b binding	CFH CFHR1 CFHR5	8.87e-05	12	151	3	GO:0001851
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RGPD4 RGPD2 RANBP2 DENND4A PSD2 RASA1 ARHGAP23 MYCBP2 ASAP3 TBC1D10B TBC1D10A RGPD3 SERGEF	1.29e-04	507	151	13	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RGPD4 RGPD2 RANBP2 DENND4A PSD2 RASA1 ARHGAP23 MYCBP2 ASAP3 TBC1D10B TBC1D10A RGPD3 SERGEF	1.29e-04	507	151	13	GO:0030695
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD4 RGPD2 RANBP2 RGPD3	1.53e-04	36	151	4	GO:0019789
GeneOntologyMolecularFunction	GTPase activator activity	RGPD4 RGPD2 RANBP2 RASA1 ARHGAP23 ASAP3 TBC1D10B TBC1D10A RGPD3	2.80e-04	279	151	9	GO:0005096
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	RGPD4 RGPD2 RANBP2 RGPD3	5.52e-04	50	151	4	GO:0003755
GeneOntologyMolecularFunction	CoA-transferase activity	ACSM3 SUGCT	5.60e-04	5	151	2	GO:0008410
GeneOntologyMolecularFunction	cis-trans isomerase activity	RGPD4 RGPD2 RANBP2 RGPD3	6.90e-04	53	151	4	GO:0016859
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RGPD2 RANBP2 RGPD3	3.20e-07	9	149	4	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RGPD2 RANBP2 RGPD3	5.31e-07	10	149	4	GO:1903301
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD4 RGPD2 RANBP2 RGPD3	1.78e-06	13	149	4	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD4 RGPD2 RANBP2 RGPD3	2.47e-06	14	149	4	GO:1903299
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD4 RGPD2 RANBP2 RGPD3	1.16e-05	20	149	4	GO:0006607
GeneOntologyBiologicalProcess	intestinal epithelial cell differentiation	TMIGD1 C1GALT1 CBFA2T2 SPDEF	1.02e-04	34	149	4	GO:0060575
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RGPD2 RANBP2 RGPD3	1.70e-07	8	149	4	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RGPD2 RANBP2 RGPD3	5.04e-07	10	149	4	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RGPD2 RANBP2 RGPD3	2.35e-06	14	149	4	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RGPD2 RANBP2 RGPD3	7.02e-06	18	149	4	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RGPD2 RANBP2 RGPD3	1.10e-05	20	149	4	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RGPD2 RANBP2 RGPD3	1.35e-05	21	149	4	GO:0106068
GeneOntologyCellularComponent	transferase complex	RGPD4 CUL1 RGPD2 RANBP2 SPOPL PDSS1 PDHB KLHL40 SENP3 RB1CC1 DPM1 POLR3F CDK13 RGPD3 ANKIB1 SPOP TAF5L	5.19e-04	963	149	17	GO:1990234
MousePheno	abnormal morula morphology	RGPD4 RGPD2 RANBP2 CHERP RGPD3	2.76e-06	26	123	5	MP:0012058
MousePheno	elevated level of mitotic sister chromatid exchange	RGPD4 RGPD2 RANBP2 RGPD3	9.57e-06	16	123	4	MP:0003701
Domain	Ran_BP1	RGPD4 RGPD2 RANBP2 RGPD3	1.93e-06	12	151	4	PF00638
Domain	RANBD1	RGPD4 RGPD2 RANBP2 RGPD3	1.93e-06	12	151	4	PS50196
Domain	RanBD	RGPD4 RGPD2 RANBP2 RGPD3	2.77e-06	13	151	4	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD2 RANBP2 RGPD3	2.77e-06	13	151	4	IPR000156
Domain	Rab_bind	RGPD4 RGPD2 RGPD3	1.77e-05	7	151	3	PF16704
Domain	GCC2_Rab_bind	RGPD4 RGPD2 RGPD3	1.77e-05	7	151	3	IPR032023
Domain	-	RGPD4 RGPD2 RGPD3	5.96e-05	10	151	3	1.10.220.60
Domain	Grip	RGPD4 RGPD2 RGPD3	8.15e-05	11	151	3	SM00755
Domain	GRIP	RGPD4 RGPD2 RGPD3	8.15e-05	11	151	3	PF01465
Domain	MATH	SPOPL TRAF4 SPOP	1.08e-04	12	151	3	PS50144
Domain	GRIP_dom	RGPD4 RGPD2 RGPD3	1.08e-04	12	151	3	IPR000237
Domain	GRIP	RGPD4 RGPD2 RGPD3	1.08e-04	12	151	3	PS50913
Domain	MATH/TRAF_dom	SPOPL TRAF4 SPOP	1.08e-04	12	151	3	IPR002083
Domain	MATH	SPOPL TRAF4 SPOP	1.08e-04	12	151	3	SM00061
Domain	MATH	SPOPL TRAF4 SPOP	1.08e-04	12	151	3	PF00917
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH1 MDN1	1.77e-04	14	151	3	IPR011704
Domain	-	SPOPL TRAF4 SPOP	1.77e-04	14	151	3	2.60.210.10
Domain	AAA_5	DNAH3 DNAH1 MDN1	1.77e-04	14	151	3	PF07728
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFH CFHR1 CFHR5	9.09e-06	6	110	3	M47880
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD4 RGPD2 RANBP2 RGPD3	9.87e-06	18	110	4	MM1549
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RGPD4 RGPD2 RANBP2 RGPD3 FIP1L1	4.23e-05	50	110	5	MM14610
Pathway	REACTOME_SNRNP_ASSEMBLY	RGPD4 RGPD2 RANBP2 RGPD3 GEMIN4	8.70e-05	58	110	5	MM14736
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RGPD4 RGPD2 RANBP2 RGPD3	2.58e-04	40	110	4	MM14945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RGPD4 RGPD2 RANBP2 RGPD3	2.85e-04	41	110	4	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RGPD4 RGPD2 RANBP2 RGPD3	3.13e-04	42	110	4	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RGPD4 RGPD2 RANBP2 RGPD3	3.43e-04	43	110	4	MM14609
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	9037092
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	38838144
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	38657106
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	25187515
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	8603673
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	23818861
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	23536549
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD2 RANBP2 RGPD3	1.21e-08	7	152	4	20682751
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD2 RANBP2 RGPD3	2.42e-08	8	152	4	21670213
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD2 RANBP2 RGPD3	2.42e-08	8	152	4	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD2 RANBP2 RGPD3	2.42e-08	8	152	4	21310149
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD2 RANBP2 RGPD3	2.42e-08	8	152	4	22262462
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD2 RANBP2 RGPD3	2.42e-08	8	152	4	28745977
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD2 RANBP2 RGPD3	4.34e-08	9	152	4	18394993
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD2 RANBP2 RGPD3	4.34e-08	9	152	4	28100513
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD2 RANBP2 RGPD3	4.34e-08	9	152	4	17887960
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD2 RANBP2 RGPD3	4.34e-08	9	152	4	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD2 RANBP2 RGPD3	4.34e-08	9	152	4	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD2 RANBP2 RGPD3	4.34e-08	9	152	4	9733766
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD2 RANBP2 RGPD3	4.34e-08	9	152	4	28877029
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CFH DMXL2 FOXRED1 MYCBP2 PDHB TERF1 CIT DPM1 WDR59 RPH3A YARS1 SERGEF PKD1 ARID5B TOLLIP FIP1L1 PDZD8 CERCAM FUT8 MAP4K4 SNRNP200 SCAI	4.75e-08	1285	152	22	35914814
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RGPD2 RANBP2 RGPD3	7.22e-08	10	152	4	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD2 RANBP2 RGPD3	7.22e-08	10	152	4	16332688
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD2 RANBP2 RGPD3	7.22e-08	10	152	4	8857542
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD2 RANBP2 RGPD3	7.22e-08	10	152	4	21859863
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD2 RANBP2 RGPD3	1.13e-07	11	152	4	17069463
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD2 RANBP2 RGPD3	1.13e-07	11	152	4	35771867
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RGPD2 RANBP2 RGPD3	1.13e-07	11	152	4	34110283
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RGPD2 RANBP2 RGPD3	2.43e-07	13	152	4	31427429
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RANBP2 DMXL2 CHERP MYCBP2 PDHB FNBP4 RPSA CHD2 ADNP TERF1 TBC1D10B SEC11A GNL2 FIP1L1 TAF5L MAP4K4 AGRN SNRNP200 HSDL1	2.90e-07	1082	152	19	38697112
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD4 RGPD2 RANBP2 WWOX MYCBP2 RB1CC1 ADNP NEK1 RGPD3 ARID5B GEMIN4 TBL1X	3.48e-07	418	152	12	34709266
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 RGPD2 RANBP2 RGPD3	4.61e-07	15	152	4	14697343
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CUL1 ARMT1 RANBP2 DENND4A RPL35A MYCBP2 RO60 XRCC1 RB1CC1 DPM1 YARS1 PPP2R2A CCDC82 SEC11A GNL2 GEMIN4 SPOP ADI1 SNRNP200 HSDL1	9.00e-07	1284	152	20	17353931
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD4 RGPD2 RANBP2 DMXL2 MYCBP2 SENP3 SPECC1L ADNP GRM5 CIT RPH3A MDN1 RGPD3 EML1 MAP4K4 AGRN TBL1X	1.19e-06	963	152	17	28671696
Pubmed	Dimerization of complement factor H-related proteins modulates complement activation in vivo.	CFH CFHR1 CFHR5	1.62e-06	6	152	3	23487775
Pubmed	Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.	CFH CFHR1 CFHR5	1.62e-06	6	152	3	27196323
Pubmed	Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.	CFH CFHR1 CFHR5	1.62e-06	6	152	3	17438673
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ALKBH4 MYCBP2 RPSA CFAP43 MAPKAPK5 CIT CDC14B WDR59 TRAF4 MDN1 CDK13 PKD1 SORBS3 PDZD8 NLE1 POLL ATG9A AGRN	1.77e-06	1105	152	18	35748872
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CUL1 RANBP2 RPL35A ARHGAP23 MYCBP2 PDHB SENP3 RPSA CHD2 ADNP NCAPG2 DPM1 WDR59 MDN1 ANKIB1 GEMIN4 FIP1L1 NLE1 AGRN SNRNP200	2.00e-06	1353	152	20	29467282
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RGPD4 RGPD2 RANBP2 RGPD3	2.41e-06	22	152	4	27717094
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RANBP2 RPL35A SENP3 RPSA CHD2 SPECC1L XRCC1 CIT SYT7 MDN1 TBC1D10A CDK13 RGPD3 GNL2 GEMIN4 TOLLIP TFB2M TAF5L FUT8 AGRN RBFA	2.47e-06	1497	152	21	31527615
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RGPD4 CUL1 RGPD2 RANBP2 RPL35A MYCBP2 PDHB RPSA NCAPG2 DPM1 PPP2R2A MDN1 SEC11A RGPD3 GEMIN4 FIP1L1 TFB2M SNRNP200 HSDL1	2.67e-06	1257	152	19	37317656
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD2 RGPD3	2.83e-06	7	152	3	15710750
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CUL1 RANBP2 RPL35A CHERP SENP3 FNBP4 CHD2 XRCC1 ADNP TERF1 DPM1 MDN1 CDK13 RGPD3 ARID5B FIP1L1 TAF5L SNRNP200 TBL1X	4.06e-06	1294	152	19	30804502
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CUL1 RANBP2 DENND4A RPL35A CHERP PDHB RPSA RO60 ADNP DPM1 YARS1 PPP2R2A MDN1 SEC11A GNL2 GEMIN4 SCPEP1 TAF5L MAP4K4 SNRNP200	4.35e-06	1425	152	20	30948266
Pubmed	C3 Glomerulopathy	CFH CFHR1 CFHR5	4.51e-06	8	152	3	20301598
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RANBP2 RPL35A CHERP SENP3 FNBP4 RPSA SPECC1L DPM1 MDN1 CBFA2T2 GNL2 GEMIN4 FIP1L1 SPDEF SNRNP200	5.05e-06	847	152	15	35850772
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD4 RGPD2 RANBP2 DENND4A FOXRED1 ZNF789 KRT19 PDHB FAM47B CHD2 RNF17 ACSM3 MDN1 SUGCT CDK13 RGPD3 NLE1 SPDEF RBFA MYBPC2	5.19e-06	1442	152	20	35575683
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	RGPD4 RGPD2 RANBP2 MDN1 RGPD3 SNRNP200 TBL1X	5.27e-06	153	152	7	26365490
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DMXL2 DENND4A ARHGAP23 SENP3 NCAPG2 DPM1 FREM2 TBC1D10B CDK13 ANKIB1 MAP4K4 AGRN HSDL1	6.15e-06	650	152	13	38777146
Pubmed	Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.	CFH CFHR1 CFHR5	6.74e-06	9	152	3	20059470
Pubmed	FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.	CFH CFHR1 CFHR5	6.74e-06	9	152	3	28533443
Pubmed	CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable.	RB1CC1 ATG9A	1.90e-05	2	152	2	23402761
Pubmed	Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).	CFH CFHR5	1.90e-05	2	152	2	16299065
Pubmed	Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins.	TBC1D10B TBC1D10A	1.90e-05	2	152	2	31527750
Pubmed	The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.	RB1CC1 ATG9A	1.90e-05	2	152	2	21525242
Pubmed	TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells.	ANO1 PKD1	1.90e-05	2	152	2	32185407
Pubmed	Factor H and CFHR1 polymorphisms associated with atypical Haemolytic Uraemic Syndrome (aHUS) are differently expressed in Tunisian and in Caucasian populations.	CFH CFHR1	1.90e-05	2	152	2	22136554
Pubmed	Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.	CFH CFHR1	1.90e-05	2	152	2	18824548
Pubmed	A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death checkpoints to repress TNF cytotoxicity.	RB1CC1 ATG9A	1.90e-05	2	152	2	36892222
Pubmed	Anti-factor H autoantibody-associated hemolytic uremic syndrome: review of literature of the autoimmune form of HUS.	CFH CFHR1	1.90e-05	2	152	2	20865640
Pubmed	A synthetic protein as efficient multitarget regulator against complement over-activation.	CFH CFHR1	1.90e-05	2	152	2	35194132
Pubmed	Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome.	CFH CFHR1	1.90e-05	2	152	2	23243267
Pubmed	Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule.	CFH CFHR1	1.90e-05	2	152	2	1826708
Pubmed	Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells.	CFH CFHR1	1.90e-05	2	152	2	24280833
Pubmed	A novel hybrid CFHR1/CFH gene causes atypical hemolytic uremic syndrome.	CFH CFHR1	1.90e-05	2	152	2	23880784
Pubmed	Binding of the human complement regulators CFHR1 and factor H by streptococcal collagen-like protein 1 (Scl1) via their conserved C termini allows control of the complement cascade at multiple levels.	CFH CFHR1	1.90e-05	2	152	2	20855886
Pubmed	Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma.	CFH CFHR1	1.90e-05	2	152	2	23938460
Pubmed	CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome.	CFH CFHR1	1.90e-05	2	152	2	36755127
Pubmed	Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces.	CFH CFHR1	1.90e-05	2	152	2	33732239
Pubmed	The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells †.	TBC1D10B TBC1D10A	1.90e-05	2	152	2	34757852
Pubmed	A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.	SPOPL SPOP	1.90e-05	2	152	2	16740475
Pubmed	Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules.	CFH CFHR1	1.90e-05	2	152	2	15557185
Pubmed	Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome.	CFH CFHR1	1.90e-05	2	152	2	21677636
Pubmed	Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern.	SPOPL SPOP	1.90e-05	2	152	2	20399258
Pubmed	Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.	ANO1 PKD1	1.90e-05	2	152	2	32859916
Pubmed	Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.	CFHR1 CFHR5	1.90e-05	2	152	2	35392081
Pubmed	Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome.	CFH CFHR1	1.90e-05	2	152	2	22894814
Pubmed	Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy.	CFHR1 CFHR5	1.90e-05	2	152	2	28673452
Pubmed	A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.	CFHR1 CFHR5	1.90e-05	2	152	2	28729035
Pubmed	Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.	CFH CFHR1	1.90e-05	2	152	2	23873044
Pubmed	The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system.	MYCBP2 ROBO2	1.90e-05	2	152	2	23525682
Pubmed	The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease.	CFH CFHR1	1.90e-05	2	152	2	25659429
Pubmed	Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.	SPOPL SPOP	1.90e-05	2	152	2	16651542
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD4 RGPD2 RANBP2 RGPD3	2.31e-05	38	152	4	12791264
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	WWOX MYCBP2 SENP3 XRCC1 ATE1 NEK1 TBC1D10B PPP2R2A FIP1L1 FUT8 SCAI	2.45e-05	533	152	11	25544563
Pubmed	Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.	MYCBP2 CHD2 CIT TRAF4 CDK13	2.59e-05	79	152	5	29121065
Pubmed	Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.	RGPD4 RGPD2 RANBP2 RGPD3 ARID5B FIP1L1	2.98e-05	135	152	6	31077711
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	CUL1 FOXRED1 RPL35A MOSPD2 WWOX MYCBP2 PDSS1 PDHB COQ5 YARS1 MDN1 CDK13 GNL2 GEMIN4 SCO1 PDZD8 MTO1 HSDL1 RBFA	3.07e-05	1496	152	19	32877691
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	RGPD4 RGPD2 RANBP2 KRT19 PDHB RPSA YARS1 PPP2R2A CDK13 RGPD3 MAP4K4 SNRNP200	3.87e-05	665	152	12	30457570
Interaction	RGPD3 interactions	RGPD4 RGPD2 RANBP2 CIT RGPD3 SPOP	1.33e-06	47	151	6	int:RGPD3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFH CFHR1 RO60 CFHR5	1.17e-04	75	152	4	chr1q31
GeneFamily	WD repeat domain containing	DMXL2 CFAP43 WDR59 PPP2R2A NLE1 TAF5L EML1 TBL1X	1.45e-04	262	105	8	362
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RGPD2 RANBP2 TTC39C RGPD3	5.55e-04	115	105	5	769
GeneFamily	Complement system\|Sushi domain containing	CFH CFHR1 CFHR5	1.18e-03	36	105	3	492
GeneFamily	AAA ATPases\|Mitochondrial respiratory chain complex assembly factors	FOXRED1 COX18 SCO1	1.61e-03	40	105	3	645
GeneFamily	X-linked mental retardation\|RNA helicases	IFIH1 SNRNP200	1.78e-03	11	105	2	1168
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CUL1 RANBP2 DMXL2 RASA1 MYCBP2 SPECC1L RB1CC1 ADNP TERF1 TXNRD1 NEK1 PPP2R2A MDN1 CDK13 ARID5B SPOP FUT8 SLC23A2 TBL1X	5.28e-07	856	151	19	M4500
Coexpression	GSE17721_LPS_VS_PAM3CSK4_12H_BMDC_UP	PDSS1 FNBP4 COX18 TMCO4 ADPRH PPP2R2A ANKIB1 SPOP FUT8	2.54e-06	200	151	9	M3925
Coexpression	MARSON_BOUND_BY_FOXP3_UNSTIMULATED	RGPD4 TMIGD1 RGPD2 RANBP2 INPP1 CFAP43 TEC ARL15 TERF1 TBC1D10B PPP2R2A SUGCT TTLL6 SEC11A RGPD3 ARID5B TFB2M MTO1 NYAP1 MAP4K4 KCNAB3 TBL1X	4.23e-06	1277	151	22	MM1032
Coexpression	TABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING	RGPD4 RGPD2 RANBP2 TBC1D10A RGPD3	4.79e-06	43	151	5	MM3857
Coexpression	GSE27786_NKTCELL_VS_NEUTROPHIL_UP	CUL1 PDHB FNBP4 PPP2R2A MDN1 GNL2 ADI1 TBL1X	2.18e-05	200	151	8	M4868
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP	RGPD4 RGPD2 RANBP2 RGPD3	3.80e-05	33	151	4	MM477
Coexpression	FOSTER_TOLERANT_MACROPHAGE_DN	RGPD4 RGPD2 RANBP2 PDSS1 INPP1 FNBP4 WDR59 IFIH1 RGPD3 SLFN11 AGRN	4.65e-05	435	151	11	MM1221
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 KRT19 CFAP43 DNAH1 FREM2 P2RX6 TTLL6	1.56e-06	164	152	7	e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE GRM5 C8orf34 HRH1 CERCAM ALDH1A3 TBL1X	3.23e-06	183	152	7	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE ABCA4 GRM5 C8orf34 HRH1 ALDH1A3 TBL1X	3.23e-06	183	152	7	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	RGPD2 RANBP2 DENND4A FNBP4 CHD2 RB1CC1 TRAF4	4.28e-06	191	152	7	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CFH CFHR1 KRT19 BDKRB2 TRAF4 SPDEF ROBO2	5.42e-06	198	152	7	a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRHDE COX18 DNAH1 ACSBG1 TEC RBFA	5.44e-06	129	152	6	2f30b4897343586c9b49a1d2bec3007ec737085c
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial\|2m / Sample Type, Dataset, Time_group, and Cell type.	FOXS1 CFH IGFN1 ANO1 BDKRB2 ALDH1A3 CTSK	5.79e-06	200	152	7	3da9441c0f1e242f0d195de47ecd4c24dfdca232
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial-Proteoglycan-expressing_cell\|2m / Sample Type, Dataset, Time_group, and Cell type.	FOXS1 CFH IGFN1 ANO1 BDKRB2 ALDH1A3 CTSK	5.79e-06	200	152	7	eed2bafddcd041ef5fcc4d1d31edb8be4d83ce01
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 IQCH CFAP43 DNAH1 P2RX6 TTLL6	1.55e-05	155	152	6	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 IQCH CFAP43 DNAH1 P2RX6 TTLL6	1.55e-05	155	152	6	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-ectodermal/neuroectodermal-like_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	RPL35A KRT19 TMCO4 IFIH1 ACSM3 SLFN11	2.29e-05	166	152	6	d7e49416426a62801ea1062d7aaf55ea622ae118
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXRED1 IL18RAP CDC14B POLR3F HAVCR2 EBPL	2.45e-05	168	152	6	93b7138f17aa14a6398c9b4ea7237781a0e19a66
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXRED1 IL18RAP CDC14B POLR3F HAVCR2 EBPL	2.45e-05	168	152	6	e393553208617a023f1646169c892a87c95db3f5
Disease	C3 glomerulopathy	CFH CFHR1 CFHR5	9.75e-06	9	146	3	C4087273
Disease	hemopexin measurement	CFH CFHR1 CFHR5	1.90e-05	11	146	3	EFO_0008149
Disease	complement factor H-related protein 3 measurement	CFH CFHR1 WWOX CFHR5 NEK1 ARID5B MAP4K4	2.22e-05	169	146	7	EFO_0600056
Disease	CFHR5 DEFICIENCY	CFHR1 CFHR5	2.43e-05	2	146	2	C3553720
Disease	4-hydroxyphenylacetylglutamine measurement	DNAH3 ACSM3	7.27e-05	3	146	2	EFO_0800688
Disease	anaphase-promoting complex subunit 7 measurement	CFH CFHR1	7.27e-05	3	146	2	EFO_0801381
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR1	7.27e-05	3	146	2	C2749604
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR1	7.27e-05	3	146	2	235400
Disease	calnexin measurement	CFH CFHR1	7.27e-05	3	146	2	EFO_0801444
Disease	complement factor H-related protein 4A measurement	CFH CFHR1	7.27e-05	3	146	2	EFO_0600057
Disease	Hemolytic uremic syndrome, atypical, susceptibility to, 1	CFH CFHR1	7.27e-05	3	146	2	cv:C2749604
Disease	histone-lysine N-methyltransferase 2D measurement	CFH CFHR1	7.27e-05	3	146	2	EFO_0801683
Disease	age-related macular degeneration	CFH CFHR1 CFHR5 GRM5 SCPEP1	8.23e-05	89	146	5	EFO_0001365
Disease	Age-related macular degeneration	CFH CFHR1 ABCA4	9.17e-05	18	146	3	cv:C0242383
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR1	1.45e-04	4	146	2	EFO_0803292
Disease	kallikrein-5 measurement	CFH CFHR1	1.45e-04	4	146	2	EFO_0020515
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	1.45e-04	4	146	2	EFO_0020830
Disease	acidic leucine-rich nuclear phosphoprotein 32 family member A measurement	CFH RPSA	2.41e-04	5	146	2	EFO_0802250
Disease	semaphorin-6B measurement	CFH PDHB	2.41e-04	5	146	2	EFO_0021885
Disease	Membranoproliferative Glomerulonephritis, Type II	CFH CFHR1	3.60e-04	6	146	2	C0268743
Disease	complement C1s subcomponent measurement	CFH CFHR1	3.60e-04	6	146	2	EFO_0008091
Disease	Age related macular degeneration	CFH CFHR1 ABCA4	4.37e-04	30	146	3	C0242383
Disease	Tinnitus	ANO1 RB1CC1 C8orf34 ARID5B FIP1L1	4.83e-04	130	146	5	HP_0000360
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	CHD2 ROBO2	5.02e-04	7	146	2	DOID:0060475 (implicated_via_orthology)
Disease	keratinocyte differentiation-associated protein measurement	CFH RPSA	5.02e-04	7	146	2	EFO_0801743
Disease	heterogeneous nuclear ribonucleoproteins C1/C2 measurement	CFH RPSA	5.02e-04	7	146	2	EFO_0801675
Disease	Complement deficiency disease	CFH CFHR1 CFHR5	5.81e-04	33	146	3	C0272242
Disease	hepatitis A virus cellular receptor 2 measurement	CFH HAVCR2	6.68e-04	8	146	2	EFO_0008151
Disease	chitinase-3-like protein 2 measurement	CFH RPSA	6.68e-04	8	146	2	EFO_0801471
Disease	atypical hemolytic-uremic syndrome (is_implicated_in)	CFH CFHR1	6.68e-04	8	146	2	DOID:0080301 (is_implicated_in)
Disease	X-17676 measurement	DNAH3 ACSM3	6.68e-04	8	146	2	EFO_0800785
Disease	dihydroorotate measurement	ARL15 ACSBG1	8.56e-04	9	146	2	EFO_0800647
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR1	8.56e-04	9	146	2	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFHR1	8.56e-04	9	146	2	cv:C0019061
Disease	Oxidative Phosphorylation Deficiencies	FOXRED1 SCO1	8.56e-04	9	146	2	C0949856
Disease	Mitochondrial Respiratory Chain Deficiencies	FOXRED1 SCO1	8.56e-04	9	146	2	C0949857
Disease	Electron Transport Chain Deficiencies, Mitochondrial	FOXRED1 SCO1	8.56e-04	9	146	2	C0949855
Disease	Graves Disease	IFIH1 ARID5B	8.56e-04	9	146	2	C0018213
Disease	leukocyte immunoglobulin-like receptor subfamily A member 5 measurement	CFH CFHR1	8.56e-04	9	146	2	EFO_0801766
Disease	transcription factor IIIb 90 kda subunit measurement	CFH RPSA	1.07e-03	10	146	2	EFO_0020778
Disease	Diamond-Blackfan anemia (implicated_via_orthology)	RPL35A RPSA	1.07e-03	10	146	2	DOID:1339 (implicated_via_orthology)
Disease	Atypical Hemolytic Uremic Syndrome	CFH CFHR1	1.07e-03	10	146	2	C2931788
Disease	bone morphogenetic protein 7 measurement	CFH CDC14B	1.07e-03	10	146	2	EFO_0020187
Disease	transmembrane glycoprotein NMB measurement	CFH SEC11A	1.07e-03	10	146	2	EFO_0008303
Disease	complement factor H-related protein 5 measurement	CFH CFHR1 CFHR5	1.18e-03	42	146	3	EFO_0008098
Disease	PR domain zinc finger protein 1 measurement	CFH RPSA	1.30e-03	11	146	2	EFO_0801904
Disease	DNA repair protein RAD51 homolog 4 measurement	CFH ZNF789	1.30e-03	11	146	2	EFO_0801531
Disease	urinary uromodulin measurement	DNAH3 WWOX ACSM3 TOLLIP	1.34e-03	96	146	4	EFO_0005663
Disease	pulse pressure measurement	CFH IQCH SETD6 ANO1 CHD2 TEC ARL15 RPH3A SUGCT TTLL6 PKD1 HRH1 CERCAM EML1 TEC SCAI	1.50e-03	1392	146	16	EFO_0005763
Disease	esophageal cancer (is_implicated_in)	WWOX XRCC1	1.83e-03	13	146	2	DOID:5041 (is_implicated_in)
Disease	lung adenocarcinoma (is_implicated_in)	XRCC1 SPOP MAP4K4	1.85e-03	49	146	3	DOID:3910 (is_implicated_in)
Disease	complement factor H-related protein 4 measurement	CFH CFHR1 CFHR5	1.85e-03	49	146	3	EFO_0600091
Disease	hepatocellular carcinoma (is_implicated_in)	XRCC1 HAVCR2 CDK13 SPOP MAP4K4	2.11e-03	181	146	5	DOID:684 (is_implicated_in)
Disease	early cardiac repolarization measurement	MYCBP2 PDZD8	2.13e-03	14	146	2	EFO_0004885
Disease	glycerate measurement	SLC23A2 AGRN	2.45e-03	15	146	2	EFO_0021029
Disease	complement factor H-related protein 1 measurement	CFH CFHR1 CFHR5	2.72e-03	56	146	3	EFO_0600054
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	NEK1 PKD1	2.79e-03	16	146	2	DOID:0110861 (implicated_via_orthology)
Disease	abdominal fat cell number	TRHDE C1GALT1 TEC CBFA2T2 TEC	3.11e-03	198	146	5	EFO_0021534
Disease	atrophic macular degeneration, age-related macular degeneration, wet macular degeneration	CFH CFHR1 CFHR5	3.30e-03	60	146	3	EFO_0001365, EFO_0004683, EFO_1001492
Disease	cystathionine measurement	TEC TEC	3.93e-03	19	146	2	EFO_0010474
Disease	coagulation factor measurement	CFH CFHR5	4.36e-03	20	146	2	EFO_0004634
Disease	ST2 protein measurement	IL18RAP MAP4K4	4.80e-03	21	146	2	EFO_0010599

Protein segments in the cluster

Peptide	Gene	Start	Entry
ANYLIGQKEAKRWGT	SUGCT	256	Q9HAC7
RDKWKILNTRYGEAL	TRHDE	941	Q9UKU6
WEGRAPDSVDYRKKG	CTSK	111	P43235
PWKLSQSGRRKQDYG	ALKBH4	96	Q9NXW9
GDREQLKWKNSSYGK	ADNP	1021	Q9H2P0
GDLNYRKLTGDRKWE	ARMT1	366	Q9H993
GKRFRKKSWEVYQGV	BDKRB2	336	P30411
NGRDDGTLVYLKWKR	CFAP43	701	Q8NDM7
VGFLYKKSDGIRRVW	ASAP3	306	Q8TDY4
QLGWSKRDARLTYLK	COX18	136	Q8N8Q8
KELGGADNIRKYWSR	ARL15	81	Q9NXU5
TNKIKDRYWDSGPRA	ABCA4	581	P78363
LWKISERDKRPEGYN	PPP2R2A	121	P63151
AKWRKRERYGKIQEG	ALX3	206	O95076
NLWLEGDYFRQKLKG	CDC14B	366	O60729
WRYLKGKDLVARESL	AGRN	71	O00468
LRYFAGWADKIQGKT	ALDH1A3	141	P47895
KGTRRDFRSYDKPWQ	C8orf34	161	Q49A92
AREYGGSKRNALLKW	SPECC1L	1006	Q69YQ0
LKWKGAKLDQGEYER	ANKIB1	121	Q9P2G1
LRWTAKQKLYSRTGE	CFH	1181	P08603
GGKLRFQLYNWLEKE	DMXL2	2066	Q8TDJ6
YRWGDIKINIIGEKD	CBLL2	36	Q8N7E2
RYGETKEKDIDWGKR	CDK13	686	Q14004
QGWDRKYIVLEGSKV	CIT	1461	O14578
NGGVYGWDLKRKIIS	DPM1	151	O60762
GWDLKRKIISRGANF	DPM1	156	O60762
GDKWRALGYAKAINA	POLL	271	Q9UGP5
TDLGVLYDWKERLKQ	DENND4A	101	Q7Z401
YKRRKDKGLGGLVWQ	RBFA	251	Q8N0V3
KNDVTDGRAKYWLER	RANBP2	106	P49792
RYDKDVGQWKERGIG	RANBP2	2341	P49792
KGKRWKNLYFILEGS	RASA1	486	P20936
VLKESSRYGLEDWRK	IQCH	681	Q86VS3
WAGALVKDGKRLYEA	RB1CC1	516	Q8TDY2
RGLWKKYGDKRIIDT	PDHB	71	P11177
TRKEGWKRRHEDGYL	DAOA	56	P59103
KGNTLKEDWIAYISR	MAP4K4	121	O95819
WANKGGLIAYRSRKR	INPP1	366	P49441
WYKNGKLLSVERSNR	IL18RAP	191	O95256
GELEVKIRDWYQKQG	KRT19	106	P08727
KIGLSYRKGLAWARS	MDN1	4136	Q9NU22
YRKGLAWARSKNPQE	MDN1	4141	Q9NU22
GQSKRIWGELYKVID	GNL2	201	Q13823
WKRRGSSGETLRYKD	GRM5	866	P41594
WNGRGFTDKVDRLKL	MAPKAPK5	441	Q8IW41
NEAKWKREIYGRGLP	NEK1	461	Q96PY6
ETRYKESWSKLRDGG	NRAP	1026	Q86VF7
ESWSKLRDGGYKLRL	NRAP	1031	Q86VF7
AVWGLRAQIDRKLYK	MTO1	121	Q9Y2Z2
KQELLRGLWRKEGAF	FREM2	621	Q5SZK8
VIRGEKYDGRKADVW	BRSK2	186	Q8IWQ3
WKRRYNENTELRKTG	CBFA2T2	386	O43439
SSEILYRNKLGKWTR	PDZD8	681	Q8NEN9
RKLRDFKWAGDLGVN	FAM47B	461	Q8NA70
RKANSSVGKWQDRYG	FIP1L1	286	Q6UN15
LIASLWKEYGKADAR	EBPL	76	Q9BY08
KKWEGVLREIAYAAG	KLHL40	591	Q2TBA0
KDIGIWYNILRGIGK	ANO1	781	Q5XXA6
WGYRQLEIVGEKLSR	POMT1	486	Q9Y6A1
RYDKDVGQWKERGIG	RGPD3	1366	A6NKT7
GWYDRKIIGAFKNLV	DNAH1	2321	Q9P2D7
VRALWKKLGSNVGVY	HBQ1	11	P09105
FRRSKENGWIKEKYG	CCDC82	511	Q8N4S0
VRDKWDQYKGVGVAL	CHERP	876	Q8IWX8
YIKGLFLEGARWDRK	DNAH3	4016	Q8TD57
WILTRNYKALAKGTR	CHD2	731	O14647
FKLGWRDLKGLYEDI	PDSS1	96	Q5T2R2
EKKRWLGLARYDFSG	CERK	301	Q8TCT0
GRKLTWLYQLSKGEL	CUL1	576	Q13616
EWSLKAEYKRGGQRL	ATG9A	266	Q7Z3C6
LSVAYWLKKLESRRG	FOXRED1	76	Q96CU9
LKKWYRVIGLSGDTQ	IFIH1	381	Q9BYX4
VTGWGYRKLRDKIQN	F11	516	P03951
YGDLIALGFKRQDKW	ACSBG1	116	Q96GR2
LKWRNDGKLYAKTGD	CFHR5	521	Q9BXR6
DYQDLIDRGWRRSGK	ATE1	46	O95260
KQKALAQGYRAGLAW	COQ5	181	Q5HYK3
RDDRKPGKGSYWTLD	FOXS1	81	O43638
AVGLKTKEGRDQLYW	C1GALT1	131	Q9NS00
LGYLIERRKKGSNTW	IGFN1	776	Q86VF2
DRKLISWSGNYQKLR	EML1	481	O00423
LGSRADLIKQYGRWA	HSDL1	56	Q3SXM5
NTGLDYIKFTWKRLR	HRH1	381	P35367
RWTAKQKLYLRTGES	CFHR1	281	Q03591
AEKLSWDLIYLGRKQ	CERCAM	436	Q5T4B2
TGERKTDKDYLGQWL	SCO1	146	O75880
NWGYEKRNLARVPKL	CHGB	581	P05060
WALLAKKGYQERDLE	P2RX6	56	O15547
GRFKYEILVKTGWGR	PKD1	3116	P98161
WALQRKVLYGGRKAK	NYAP1	631	Q6ZVC0
GNILKSKGWRRSSYV	KCNAB3	141	O43448
WDGYSKGVNRKLGRT	FUT8	536	Q9BYC5
FWLERYAKRENGKPV	MOSPD2	131	Q8NHP6
RKSDGIYIINLKRTW	RPSA	41	P08865
LSRNDVIGKIYLSWK	SYT7	361	O43581
KYLASAGEDQRLKLW	TAF5L	481	O75529
RLKLWDLASGTLYKE	TAF5L	491	O75529
IKLWDGRTGKYLASL	NLE1	396	Q9NVX2
WSKAIFAGYKRGLRN	RPL35A	6	P18077
RYDKDVGQWKERGIG	RGPD4	1366	Q7Z3J3
QLGRKLETYEGWKLE	SERGEF	296	Q9UGK8
VILRDEKWGGNKTYT	YARS1	276	P54577
LGISAKGERLKHWYE	RPH3A	656	Q9Y2J0
KWKRYLLIGLATVGG	TMCO4	186	Q5TGY1
FGVVRLGKWRAQYKV	TEC	381	P42680
ADWREGALNGNYLKR	FNBP4	566	Q8N3X1
WKERGIGDIKILQNY	RGPD2	1366	P0DJD1
VNKGLYREATELWGK	SCPEP1	241	Q9HB40
RYWLNGDFRKGDVSL	HAVCR2	81	Q8TDQ0
GLLSNKEVYAKLSWR	SETD6	436	Q8TBK2
EDGDWYGKAKSITRR	SLFN11	676	Q7Z7L1
PSRGEKRALWKLAYD	TFB2M	196	Q9H5Q4
GGREESISKLIKLYW	SPATA16	296	Q9BXB7
DGVWLRLNDETIKKY	MYCBP2	2511	O75592
DAGNKGIWSRDIRYK	POLR3F	101	Q9H1D9
RALRKAIADWYNEKG	RO60	146	P10155
FEIKGGYARSKNWRL	SP140L	341	Q9H930
TEKWRNKTGLDIYEG	ACSM3	361	Q53FZ2
KWENYLKLRGILDGE	ADPRH	226	P54922
KLGGYETITARRQWK	ARID5B	361	Q14865
YKPILWRGLKARNSE	NCAPG2	331	Q86XI2
KFEDGIWYRAKVIGL	RNF17	736	Q9BXT8
KWNRKGNYILSAGVD	TBL1X	336	O60907
DKLRTKGYDGVKRWT	SENP3	431	Q9H4L4
KGYDGVKRWTKNVDI	SENP3	436	Q9H4L4
SLNWGYRVALREKKV	TXNRD1	261	Q16881
LWYREEGRVDLKSGN	TMIGD1	66	Q6UXZ0
VGYTWKGLRKSDNSR	SLC23A2	626	Q9UGH3
RRGWKKFYAVLKGTI	PSD2	536	Q9BQI7
VQGKDWGFKKFIRRD	SPOPL	126	Q6IQ16
VQGKDWGFKKFIRRD	SPOP	126	O43791
GRFIRWLNKEKGIFK	SPDEF	266	O95238
KKAGSGLRQWKRVYA	ARHGAP23	706	Q9P227
EEWGLLDLKQKSLYR	ZNF274	26	Q96GC6
KVEDKWYSLSGRQGD	TOLLIP	146	Q9H0E2
KRKRVAGDLPYGWEQ	WWOX	51	Q9NZC7
YGLKRWQIGEIASKI	SCAI	116	Q8N9R8
AQLKKWRETRGELQY	TBC1D10B	616	Q4KMP7
SKRRDKRWVKYEGIG	SORBS3	111	O60504
VRWKKDDADLPRGRY	ROBO2	256	Q9HCK4
LRSGVRKYGEGNWSK	TERF1	391	P54274
DDRGLYKQGQHWLEK	SEC11A	121	P67812
IWKIGSYGRRLQEAK	TRAF4	311	Q9BUZ4
DWGDLQTYSRSRKNK	TTLL6	156	Q8N841
KYKQRRLAGAEEWVG	SLC28A1	506	O00337
SNQRVDLYKWKDGSG	WDR59	81	Q6PJI9
EKWDIITRKGGERTY	SNRNP200	591	O75643
KALELGAKYRPDWTR	XRCC1	341	P18887
RLYGSNKKADRPFWI	TRMT10B	151	Q6PF06
ELSAYIKGGWILRKA	TTC39C	151	Q8N584
LRGRAWQYLSGGKVK	TBC1D10A	116	Q9BXI6
LKDRKGRCGKGYAWI	THEG	141	Q9P2T0
AQTRWKQGRYDEDGK	ZNF789	166	Q5FWF6
WGRKGLSEKLLAYVE	GEMIN4	506	P57678
LRRLGVLYWKLDADK	ADI1	31	Q9BV57
TGYLVERKKKGSQRW	MYBPC2	671	Q14324
KELFEQGLAKFGRRW	MYSM1	126	Q5VVJ2