Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptidase activity	USP11 PRSS56 F12 MYSM1 PIK3IP1 PHEX PRCP LPA KLK9 C1R PLAT MMP2 CTSB USP48 AGBL1	1.97e-05	654	128	15	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	USP11 PRSS56 F12 PIK3IP1 PHEX LPA KLK9 C1R PLAT MMP2 CTSB USP48	2.13e-05	430	128	12	GO:0004175
GeneOntologyMolecularFunction	serine-type peptidase activity	PRSS56 F12 PRCP LPA KLK9 C1R PLAT MMP2	5.75e-05	207	128	8	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	PRSS56 F12 PRCP LPA KLK9 C1R PLAT MMP2	6.80e-05	212	128	8	GO:0017171
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCAL1 INO80 ERCC6L2 HLTF	9.03e-05	37	128	4	GO:0140658
GeneOntologyMolecularFunction	serine-type endopeptidase activity	PRSS56 F12 LPA KLK9 C1R PLAT MMP2	2.27e-04	190	128	7	GO:0004252
GeneOntologyMolecularFunction	helicase activity	SMARCAL1 WRN ZNFX1 DDX10 ERCC6L2 HLTF	5.47e-04	158	128	6	GO:0004386
Domain	Kringle-like	F12 PIK3IP1 LPA PLAT MMP2	2.16e-06	32	125	5	IPR013806
Domain	Kringle_CS	F12 PIK3IP1 LPA PLAT	4.25e-06	17	125	4	IPR018056
Domain	KRINGLE_1	F12 PIK3IP1 LPA PLAT	4.25e-06	17	125	4	PS00021
Domain	KR	F12 PIK3IP1 LPA PLAT	4.25e-06	17	125	4	SM00130
Domain	Kringle	F12 PIK3IP1 LPA PLAT	4.25e-06	17	125	4	IPR000001
Domain	KRINGLE_2	F12 PIK3IP1 LPA PLAT	4.25e-06	17	125	4	PS50070
Domain	Kringle	F12 PIK3IP1 LPA PLAT	4.25e-06	17	125	4	PF00051
Domain	SNF2_N	SMARCAL1 INO80 ERCC6L2 HLTF	5.95e-05	32	125	4	IPR000330
Domain	SNF2_N	SMARCAL1 INO80 ERCC6L2 HLTF	5.95e-05	32	125	4	PF00176
Domain	TRYPSIN_HIS	PRSS56 F12 LPA KLK9 C1R PLAT	6.70e-05	103	125	6	IPR018114
Domain	TRYPSIN_SER	PRSS56 F12 LPA KLK9 C1R PLAT	7.87e-05	106	125	6	PS00135
Domain	Helicase_C	SMARCAL1 WRN INO80 DDX10 ERCC6L2 HLTF	8.29e-05	107	125	6	PF00271
Domain	TRYPSIN_HIS	PRSS56 F12 LPA KLK9 C1R PLAT	8.29e-05	107	125	6	PS00134
Domain	HELICc	SMARCAL1 WRN INO80 DDX10 ERCC6L2 HLTF	8.29e-05	107	125	6	SM00490
Domain	Helicase_C	SMARCAL1 WRN INO80 DDX10 ERCC6L2 HLTF	8.73e-05	108	125	6	IPR001650
Domain	HELICASE_CTER	SMARCAL1 WRN INO80 DDX10 ERCC6L2 HLTF	9.19e-05	109	125	6	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCAL1 WRN INO80 DDX10 ERCC6L2 HLTF	9.19e-05	109	125	6	PS51192
Domain	DEXDc	SMARCAL1 WRN INO80 DDX10 ERCC6L2 HLTF	9.19e-05	109	125	6	SM00487
Domain	Helicase_ATP-bd	SMARCAL1 WRN INO80 DDX10 ERCC6L2 HLTF	9.67e-05	110	125	6	IPR014001
Domain	Peptidase_S1A	PRSS56 F12 LPA KLK9 C1R PLAT	1.12e-04	113	125	6	IPR001314
Domain	TRYPSIN_DOM	PRSS56 F12 LPA KLK9 C1R PLAT	1.24e-04	115	125	6	PS50240
Domain	Tryp_SPc	PRSS56 F12 LPA KLK9 C1R PLAT	1.36e-04	117	125	6	SM00020
Domain	Trypsin_dom	PRSS56 F12 LPA KLK9 C1R PLAT	1.63e-04	121	125	6	IPR001254
Domain	Trypsin	PRSS56 F12 LPA KLK9 C1R PLAT	1.63e-04	121	125	6	PF00089
Domain	Peptidase_S1_PA	PRSS56 F12 LPA KLK9 C1R PLAT	1.79e-04	123	125	6	IPR009003
Domain	FN1_2	F12 PLAT	2.64e-04	4	125	2	PS51091
Domain	fn1	F12 PLAT	2.64e-04	4	125	2	PF00039
Domain	Fibronectin_type1	F12 PLAT	2.64e-04	4	125	2	IPR000083
Domain	FN1	F12 PLAT	2.64e-04	4	125	2	SM00058
Domain	FN1_1	F12 PLAT	2.64e-04	4	125	2	PS01253
Domain	TRYPSIN_SER	PRSS56 F12 KLK9 C1R PLAT	3.46e-04	90	125	5	IPR033116
Domain	Sushi	CSMD2 CR1L C1R CSMD1	4.04e-04	52	125	4	PF00084
Domain	CCP	CSMD2 CR1L C1R CSMD1	4.67e-04	54	125	4	SM00032
Domain	SUSHI	CSMD2 CR1L C1R CSMD1	5.37e-04	56	125	4	PS50923
Domain	Sushi_SCR_CCP_dom	CSMD2 CR1L C1R CSMD1	5.74e-04	57	125	4	IPR000436
Domain	GS_dom	ACVR1C BMPR1B	9.13e-04	7	125	2	IPR003605
Domain	PKD	PKD1 SORCS2	9.13e-04	7	125	2	PF00801
Domain	GS	ACVR1C BMPR1B	9.13e-04	7	125	2	PS51256
Domain	DUSP	USP11 USP48	9.13e-04	7	125	2	PS51283
Domain	TGF_beta_GS	ACVR1C BMPR1B	9.13e-04	7	125	2	PF08515
Domain	GS	ACVR1C BMPR1B	9.13e-04	7	125	2	SM00467
Domain	-	USP11 USP48	9.13e-04	7	125	2	3.30.2230.10
Domain	Pept_C19_DUSP	USP11 USP48	9.13e-04	7	125	2	IPR006615
Domain	-	ABCC3 DNAH10 SMARCAL1 WRN ZNFX1 LRRK1 INO80 TEP1 DDX10 ERCC6L2 HLTF NLRP13 AGAP3	1.48e-03	746	125	13	3.40.50.300
Domain	PKD/Chitinase_dom	PKD1 SORCS2	1.55e-03	9	125	2	IPR022409
Domain	PKD	PKD1 SORCS2	1.55e-03	9	125	2	SM00089
Domain	P-loop_NTPase	ABCC3 DNAH10 SMARCAL1 WRN ZNFX1 LRRK1 INO80 TEP1 DDX10 MYH14 ERCC6L2 HLTF NLRP13 AGAP3	1.62e-03	848	125	14	IPR027417
Domain	Pkinase_Tyr	EPHB6 ACVR1C MST1R BMPR1B MAP3K11	1.76e-03	129	125	5	PF07714
Domain	Activin_recp	ACVR1C BMPR1B	1.93e-03	10	125	2	PF01064
Domain	Activin_recp	ACVR1C BMPR1B	1.93e-03	10	125	2	IPR000472
Domain	PKD	PKD1 SORCS2	2.35e-03	11	125	2	PS50093
Domain	PKD_dom	PKD1 SORCS2	2.35e-03	11	125	2	IPR000601
Domain	-	PKD1 SORCS2	2.35e-03	11	125	2	2.60.40.670
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB6 ACVR1C MST1R BMPR1B MAP3K11	2.36e-03	138	125	5	IPR001245
Domain	TGFB_receptor	ACVR1C BMPR1B	2.81e-03	12	125	2	IPR000333
Domain	MIRO-like	LRRK1 AGAP3	3.30e-03	13	125	2	IPR013684
Domain	OLF	ADGRL1 OLFML3	3.30e-03	13	125	2	PF02191
Domain	Roc	LRRK1 AGAP3	3.30e-03	13	125	2	PF08477
Domain	OLF	ADGRL1 OLFML3	3.30e-03	13	125	2	PS51132
Domain	-	F12 MMP2	3.30e-03	13	125	2	2.10.10.10
Domain	Olfac-like_dom	ADGRL1 OLFML3	3.30e-03	13	125	2	IPR003112
Domain	OLF	ADGRL1 OLFML3	3.30e-03	13	125	2	SM00284
Domain	FN_type2_col-bd	F12 MMP2	3.84e-03	14	125	2	IPR000562
Domain	FN2_2	F12 MMP2	3.84e-03	14	125	2	PS51092
Domain	FN2_1	F12 MMP2	3.84e-03	14	125	2	PS00023
Domain	uDENN	DENND1C SBF1	3.84e-03	14	125	2	SM00800
Domain	fn2	F12 MMP2	3.84e-03	14	125	2	PF00040
Domain	FN2	F12 MMP2	3.84e-03	14	125	2	SM00059
Domain	CUB	CSMD2 C1R CSMD1	4.31e-03	49	125	3	PF00431
Domain	uDENN	DENND1C SBF1	4.41e-03	15	125	2	PF03456
Domain	CUB	CSMD2 C1R CSMD1	4.56e-03	50	125	3	SM00042
Domain	DENN	DENND1C SBF1	5.01e-03	16	125	2	SM00799
Domain	DENN	DENND1C SBF1	5.01e-03	16	125	2	PF02141
Domain	dDENN	DENND1C SBF1	5.01e-03	16	125	2	PF03455
Domain	UDENN	DENND1C SBF1	5.01e-03	16	125	2	PS50946
Domain	DDENN	DENND1C SBF1	5.01e-03	16	125	2	PS50947
Domain	dDENN	DENND1C SBF1	5.01e-03	16	125	2	SM00801
Domain	dDENN_dom	DENND1C SBF1	5.01e-03	16	125	2	IPR005112
Domain	uDENN_dom	DENND1C SBF1	5.01e-03	16	125	2	IPR005113
Domain	DENN	DENND1C SBF1	5.01e-03	16	125	2	PS50211
Domain	DENN_dom	DENND1C SBF1	5.01e-03	16	125	2	IPR001194
Domain	EGF	HYAL4 F12 FCGBP LRP5 C1R PLAT	5.04e-03	235	125	6	SM00181
Domain	-	CSMD2 C1R CSMD1	5.09e-03	52	125	3	2.60.120.290
Domain	CUB	CSMD2 C1R CSMD1	5.37e-03	53	125	3	PS01180
Domain	Prot_kinase_dom	EPHB6 VRK3 SIK1 LRRK1 ACVR1C MST1R PHKG2 BMPR1B MAP3K11	5.64e-03	489	125	9	IPR000719
Domain	PROTEIN_KINASE_DOM	EPHB6 VRK3 SIK1 LRRK1 ACVR1C MST1R PHKG2 BMPR1B MAP3K11	5.94e-03	493	125	9	PS50011
Domain	CUB_dom	CSMD2 C1R CSMD1	6.58e-03	57	125	3	IPR000859
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ABCC3 METTL3 TEP1 LRP5 PLAT MMP2 CTSB ICA1L AGAP3	1.24e-07	214	130	9	22199357
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 LONRF1 ADGRL1 LRRK1 INO80 TEP1 BABAM2 ANO8 MST1R SBF1 PKD1 MAP3K11 LRP5 UBE3C IL17RD ADAT1 ARAP1 AGAP3	1.70e-07	1105	130	18	35748872
Pubmed	Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.	SMARCAL1 BRCA2 HLTF	5.08e-07	5	130	3	29053959
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	SMARCAL1 WRN BRCA2 HLTF	1.06e-06	21	130	4	27723720
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	AMN WRN PKD1 ROBO1 CPLANE1 ICA1L	2.17e-06	100	130	6	25807483
Pubmed	New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.	SATB2 CASR PHEX	6.01e-06	10	130	3	22527485
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EPHB6 USP11 LONRF1 HCN1 ZNFX1 NCAPH2 SEC31A MYH14 PKD1 CCDC15 MAP3K11 ROBO1 TMEM131 CTSB RECK DNMT1 AGAP3	6.38e-06	1285	130	17	35914814
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF444 ADGRL1 ZMIZ1 TEP1 BABAM2 ANO8 BMPR1B GPR158 MYH14 FAM120C LRP5 NUMB UBE3C CSMD1 ICA1L RECK ARAP1 AGAP3	1.14e-05	1489	130	18	28611215
Pubmed	Expression of RECK and matrix metalloproteinase-2 in ameloblastoma.	MMP2 RECK	1.39e-05	2	130	2	19995435
Pubmed	WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer.	WRN BRCA2	1.39e-05	2	130	2	35751457
Pubmed	A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease.	METTL3 PKD1	1.39e-05	2	130	2	33852874
Pubmed	Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.	CSMD2 CSMD1	1.39e-05	2	130	2	24408017
Pubmed	RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2.	METTL3 MMP2	1.39e-05	2	130	2	30762711
Pubmed	WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.	WRN BRCA2	1.39e-05	2	130	2	34772932
Pubmed	A genetic association study of CSMD1 and CSMD2 with cognitive function.	CSMD2 CSMD1	1.39e-05	2	130	2	27890662
Pubmed	BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.	USP11 BRCA2	1.39e-05	2	130	2	15314155
Pubmed	The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.	CSMD2 CSMD1	1.39e-05	2	130	2	21439553
Pubmed	[Clinicopathological significance of expressions of RECK and MMP-2 in esophageal squamous carcinoma].	MMP2 RECK	1.39e-05	2	130	2	20510080
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	VRK3 BAZ2B WRN INO80 THOC3 BCOR MYSM1 DDX10 HLTF USP48 DNMT1	1.90e-05	608	130	11	36089195
Pubmed	Genome-wide association of body fat distribution in African ancestry populations suggests new loci.	SATB2 BABAM2 CSMD1	2.76e-05	16	130	3	23966867
Pubmed	RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.	SMARCAL1 WRN HLTF	2.76e-05	16	130	3	26474068
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ABCC3 ZNF444 SATB2 SMARCAL1 ATG14 ZNFX1 BCOR CSMD2 BABAM2 IL17RD CTSB	2.94e-05	638	130	11	31182584
Pubmed	BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC.	BRCA2 MYH14	4.15e-05	3	130	2	24448238
Pubmed	Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.	LPA PLAT	4.15e-05	3	130	2	16818777
Pubmed	Identification of two new members of the CSMD gene family.	CSMD2 CSMD1	4.15e-05	3	130	2	12906867
Pubmed	Restoring multidrug resistance-associated protein 3 attenuates cell proliferation in the polycystic kidney.	ABCC3 PKD1	4.15e-05	3	130	2	25143454
Pubmed	Cathepsin B in osteoblasts.	PLAT CTSB	4.15e-05	3	130	2	12726991
Pubmed	Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease.	SMARCAL1 HLTF	4.15e-05	3	130	2	32971328
Pubmed	Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation.	LPA PLAT	4.15e-05	3	130	2	17717150
Pubmed	METTL3-Mediated RNA m6A Modification Regulates the Angiogenic Behaviors of Retinal Endothelial Cells by Methylating MMP2 and TIE2.	METTL3 MMP2	4.15e-05	3	130	2	37819742
Pubmed	Expression of matrix metalloproteinases-2, -9 and reversion-inducing cysteine-rich protein with Kazal motifs in gingiva in periodontal health and disease.	MMP2 RECK	4.15e-05	3	130	2	28043014
Pubmed	Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression.	MMP2 CTSB	4.15e-05	3	130	2	17442971
Pubmed	Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes.	LPA PLAT	4.15e-05	3	130	2	10559390
Pubmed	Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.	LPA PLAT	4.15e-05	3	130	2	24196407
Pubmed	Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.	SMARCAL1 HLTF	4.15e-05	3	130	2	28954549
Pubmed	Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior.	LPA PLAT	4.15e-05	3	130	2	12524546
Pubmed	Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.	CDH23 PKD1	4.15e-05	3	130	2	21865467
Pubmed	Antineoplastic activity of Newcastle disease virus strain D90 in oral squamous cell carcinoma.	MMP2 RECK	4.15e-05	3	130	2	25877754
Pubmed	Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.	LPA PLAT	4.15e-05	3	130	2	24612416
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP5 PLAT	4.15e-05	3	130	2	23925701
Pubmed	Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.	LPA PLAT	4.15e-05	3	130	2	15630096
Pubmed	Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.	LPA PLAT	4.15e-05	3	130	2	16330749
Pubmed	Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex.	SATB2 ROBO1	4.15e-05	3	130	2	22661412
Pubmed	RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin.	MMP2 RECK	4.15e-05	3	130	2	19022775
Pubmed	Skin wound healing in MMP2-deficient and MMP2 / plasminogen double-deficient mice.	LPA MMP2	4.15e-05	3	130	2	20163454
Pubmed	Gene expression profiling of peripheral blood in patients with abdominal aortic aneurysm.	LPA LRP5	4.15e-05	3	130	2	19233690
Pubmed	The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.	LPA PLAT	4.15e-05	3	130	2	14988509
Pubmed	Comparison of expression of cathepsins B and L and MMP2 in endothelial cells and in capillary sprouting in collagen gel.	MMP2 CTSB	4.15e-05	3	130	2	15255544
Pubmed	An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus.	LPA PLAT	4.15e-05	3	130	2	8987777
Pubmed	The hippocampal laminin matrix is dynamic and critical for neuronal survival.	LPA PLAT	4.15e-05	3	130	2	12857855
Pubmed	Identification and characterization of SMARCAL1 protein complexes.	SMARCAL1 WRN	4.15e-05	3	130	2	23671665
Pubmed	Tissue plasminogen activator promotes axonal outgrowth on CNS myelin after conditioned injury.	LPA PLAT	4.15e-05	3	130	2	19220707
Pubmed	Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer.	MMP2 RECK	4.15e-05	3	130	2	18425389
Pubmed	Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior.	LPA PLAT	4.15e-05	3	130	2	15522965
Pubmed	Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.	ABCC3 FCGBP CTSB PARP12	5.89e-05	56	130	4	20706999
Pubmed	Primary Cilia Deficiency Induces Intracranial Aneurysm.	PKD1 MMP2	8.28e-05	4	130	2	28800037
Pubmed	Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.	LPA PLAT	8.28e-05	4	130	2	19210287
Pubmed	Plasminogen activator induction facilitates recovery of respiratory function following spinal cord injury.	LPA PLAT	8.28e-05	4	130	2	18042398
Pubmed	Tissue plasminogen activator and plasminogen are critical for osmotic homeostasis by regulating vasopressin secretion.	LPA PLAT	8.28e-05	4	130	2	20175210
Pubmed	Development of secondary palate requires strict regulation of ECM remodeling: sequential distribution of RECK, MMP-2, MMP-3, and MMP-9.	MMP2 RECK	8.28e-05	4	130	2	20165883
Pubmed	Circular RNA CircSATB2 facilitates osteosarcoma progression through regulating the miR-661/FUS-mediated mRNA of ZNFX1.	SATB2 ZNFX1	8.28e-05	4	130	2	37984605
Pubmed	Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells.	PLAT MMP2	8.28e-05	4	130	2	26881424
Pubmed	Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.	LPA PLAT	8.28e-05	4	130	2	28270519
Pubmed	The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors.	MMP2 RECK	8.28e-05	4	130	2	16007210
Pubmed	Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush.	LPA PLAT	8.28e-05	4	130	2	11404420
Pubmed	Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.	LPA PLAT	8.28e-05	4	130	2	19286661
Pubmed	Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice.	LPA PLAT	8.28e-05	4	130	2	21931850
Pubmed	Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.	LPA PLAT	8.28e-05	4	130	2	12070304
Pubmed	Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.	LPA PLAT	8.28e-05	4	130	2	15486301
Pubmed	Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice.	LPA PLAT	8.28e-05	4	130	2	17301181
Pubmed	Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.	LPA PLAT	8.28e-05	4	130	2	16763560
Pubmed	Plasmin is essential in preventing periodontitis in mice.	LPA PLAT	8.28e-05	4	130	2	21704601
Pubmed	Insulin-like growth factor-binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin.	LPA PLAT	8.28e-05	4	130	2	16505491
Pubmed	The effects of the plasminogen pathway on scar tissue formation.	LPA PLAT	8.28e-05	4	130	2	14709993
Pubmed	Key role of tissue plasminogen activator in neurovascular coupling.	LPA PLAT	8.28e-05	4	130	2	18195371
Pubmed	RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata.	MMP2 RECK	8.28e-05	4	130	2	32661216
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	LAMB4 USP11 WRN THOC3 BABAM2 DDX10 P3H1 HLTF MMP2 CTSB USP48 ZMYM6 DNMT1	1.05e-04	1005	130	13	19615732
Pubmed	Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.	SATB2 INO80 BRCA2	1.11e-04	25	130	3	32737294
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	SATB2 NDUFA4 INO80 ZMIZ1 BCOR PRCP P3H1 HLTF	1.28e-04	396	130	8	26687479
Pubmed	c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells.	PLAT MMP2	1.38e-04	5	130	2	17382917
Pubmed	Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.	LPA PLAT	1.38e-04	5	130	2	17596135
Pubmed	Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis.	LPA PLAT	1.38e-04	5	130	2	11557572
Pubmed	Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.	LPA PLAT	1.38e-04	5	130	2	27283026
Pubmed	Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice.	LPA PLAT	1.38e-04	5	130	2	11306532
Pubmed	Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization.	LPA PLAT	1.38e-04	5	130	2	12657615
Pubmed	Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.	FANCE BRCA2	1.38e-04	5	130	2	15199141
Pubmed	The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection.	LPA PLAT	1.38e-04	5	130	2	12875972
Pubmed	Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.	FANCE BRCA2	1.38e-04	5	130	2	19704162
Pubmed	Evaluation of Lineage/Site-specific Nuclear Immunohistochemical Markers SATB2, Cyclin D1, SALL4, and BCOR in High-grade Endometrial Carcinomas.	SATB2 BCOR	1.38e-04	5	130	2	36731037
Pubmed	The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.	LPA PLAT	1.38e-04	5	130	2	11818362
Pubmed	The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.	LPA PLAT	1.38e-04	5	130	2	10880388
Pubmed	Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.	MMP2 RECK	1.38e-04	5	130	2	24095877
Pubmed	Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain.	LPA PLAT	1.38e-04	5	130	2	18628488
Pubmed	Nicotine treatment induces expression of matrix metalloproteinases in human osteoblastic Saos-2 cells.	PLAT MMP2	1.38e-04	5	130	2	17151781
Pubmed	MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.	LPA MMP2	1.38e-04	5	130	2	16147977
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	HCN1 ADGRL1 NDUFA4 ADCYAP1R1 GPR158 NUMB ROBO1 AGAP3	1.49e-04	405	130	8	38187761
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	METTL3 VRK3 WRN NOL10 INO80 THOC3 BCOR POLR1G BABAM2 DDX10 SBF1 CEBPZ FAM120C HLTF NUMB AGAP3	1.53e-04	1497	130	16	31527615
Pubmed	The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo.	USP11 LYPLA2 POLR1G	1.92e-04	30	130	3	24803591
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	PRAMEF22 ZMIZ1 ACVR1C TEP1 BMPR1B BRCA2 LRP5 DNMT1	2.03e-04	424	130	8	21731673
Pubmed	BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks.	SMARCAL1 BRCA2	2.06e-04	6	130	2	38554279
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD2 CR1L C1R CSMD1	1.36e-04	57	83	4	1179
GeneFamily	Type 1 receptor serine/threonine kinases	ACVR1C BMPR1B	4.31e-04	7	83	2	345
Coexpression	HALLMARK_COAGULATION	PDGFB USP11 F12 C1R PLAT MMP2 CTSB	5.93e-06	138	130	7	M5946
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RHCG SLC6A19 ZNF469 MTUS1 MMP2	6.37e-06	89	130	5	9e7041ab9409028007fefe53db6d1048eafae93b
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RHCG SLC6A19 ZNF469 MTUS1 MMP2	6.37e-06	89	130	5	436e1229ee28517c11dfe0a5d1cdad3477419e00
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RHCG SLC6A19 ZNF469 MTUS1 MMP2	6.37e-06	89	130	5	e7abf4af18d63c9384d25365a827e85a9adee964
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RHCG SLC6A19 ZNF469 MTUS1 MMP2	6.37e-06	89	130	5	4e5f4c0404968422703c248488e6b2ee8737dc00
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 ADCYAP1R1 SSC5D SORCS2 MMP2 CSMD1	1.80e-05	186	130	6	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	OLFML3 SSC5D SORCS2 C1R MMP2 IL17RD	1.97e-05	189	130	6	eccf3d49354a67c94f1ed7c15a98a48a5e8e2ed0
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	OLFML3 SSC5D SORCS2 C1R MMP2 IL17RD	1.97e-05	189	130	6	40764f461b8aa1d3a2c5a30590b7fb9307d47d09
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	CDH23 BMPR1B PRCP ROBO1 C1R PLAT	2.02e-05	190	130	6	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ADCYAP1R1 SSC5D SORCS2 C1R MMP2 IL17RD	2.09e-05	191	130	6	5271198116343c07202649889057e5774d7fdde3
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 ADCYAP1R1 MST1R SSC5D PLAT MMP2	2.15e-05	192	130	6	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 ADCYAP1R1 MST1R SSC5D PLAT MMP2	2.15e-05	192	130	6	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 ADCYAP1R1 MST1R SSC5D PLAT MMP2	2.15e-05	192	130	6	ac1477433704573f95111eee6263b93668d2845e
ToppCell	IPF-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	CDH23 BMPR1B PRCP ROBO1 C1R PLAT	2.28e-05	194	130	6	e8a9005963704286bcc50785bda8d7d63ec001b1
ToppCell	mild-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IRF4 LRRK1 WDFY4 PHEX BRCA2 LRP5	2.48e-05	197	130	6	0cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CDH23 IRF4 WDFY4 PHEX BRCA2 LRP5	2.48e-05	197	130	6	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NDUFA4 PIK3IP1 OSBPL6 C1R PLAT MMP2	2.55e-05	198	130	6	4a4566f86c9365a41b4cfd1609eac09bd73b3f34
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDGFB SIGLEC8 CDH23 ZNFX1 WDFY4 OLFML3	2.63e-05	199	130	6	b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BAZ2B NDUFA4 OLFML3 MTUS1 ROBO1 MMP2	2.63e-05	199	130	6	da016849b804fbf80edbfa8f8f56c9df8bbf2d51
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	OLFML3 SSC5D P3H1 ROBO1 C1R MMP2	2.70e-05	200	130	6	082e718c1da3f4fdd33a001d15ad3ddb2be985c7
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	OLFML3 SSC5D P3H1 ROBO1 C1R MMP2	2.70e-05	200	130	6	731e55070a7ff315091855bd88cda30e5a7e1a98
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CSMD2 OLFML3 KCNT2 MTUS1 C1R MMP2	2.70e-05	200	130	6	29054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BAZ2B NDUFA4 OLFML3 ROBO1 C1R MMP2	2.70e-05	200	130	6	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SLC6A19 SEMA4G FANCE P3H1 KLK9	5.88e-05	141	130	5	7ae8ead02e5aeb4106c4a30c08a7a061da3a5d6a
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THOC3 ANO8 MST1R PHF21B PARP12	6.72e-05	145	130	5	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDGFB ADGRL1 OIP5 IRF4 ZNF469	9.21e-05	155	130	5	d76a0f99ec35560d18820f9c92b69364ef2250e3
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PDGFB PIK3IP1 KCNT2 GPR158 ROBO1	9.21e-05	155	130	5	1882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	HCN1 CSMD2 GPR158 CSMD1 AGBL1	1.04e-04	159	130	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 RHCG CR1L BMPR1B SORCS2	1.10e-04	161	130	5	176a4a72bb4892932da3c834d1fea5e211847f92
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AMN SIK1 IRF4 WDFY4 ZNF469	1.27e-04	166	130	5	c8a7d94ed762e5e045ab5f74eef691ddc5f74993
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	PDGFB IRF4 WDFY4 PHEX LRP5	1.31e-04	167	130	5	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH23 ATG14 SBF1 MTUS1 UBE3C	1.31e-04	167	130	5	528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH23 ATG14 SBF1 MTUS1 UBE3C	1.31e-04	167	130	5	a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	OIP5 IRF4 WDFY4 PHEX LRP5	1.34e-04	168	130	5	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 RHCG AMN CR1L BMPR1B	1.38e-04	169	130	5	4b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 RHCG AMN CR1L BMPR1B	1.38e-04	169	130	5	a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCell	systemic_lupus_erythematosus-treated-Hematopoietic\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	EPHB6 SIGLEC8 PIK3IP1 MMP2 ICA1L	1.42e-04	170	130	5	9a18756e6721980d4b6c37bb52ddfe93ca79c5ab
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	IRF4 POLR1G WDFY4 PHEX LRP5	1.42e-04	170	130	5	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IRF4 LRRK1 WDFY4 PHEX RTN4RL2	1.46e-04	171	130	5	af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SATB2 OLFML3 KCNT2 C1R MMP2	1.50e-04	172	130	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB2 SEMA4G BRCA2 MTUS1 PHF21B	1.54e-04	173	130	5	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FCGBP FAM120C CTSB DNMT1	1.54e-04	173	130	5	1f725ff16e28636b20ef26f3fa9be8b47c89378d
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDH23 SIK1 IRF4 PHEX KCNC3	1.58e-04	174	130	5	4120656e6d6cf5435a248326b5fdbdc7b22137af
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	OLFML3 SSC5D FCGBP CFAP161 CTSB	1.58e-04	174	130	5	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	NS-moderate-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IRF4 WDFY4 BRCA2 MAP3K11 ZMYM6	1.71e-04	177	130	5	de1ffe3df76100d46ca158bdd2fea2ebbd4656b4
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)\|343B / Donor, Lineage, Cell class and subclass (all cells)	OLFML3 KCNT2 ROBO1 MMP2 RECK	1.71e-04	177	130	5	e55d21d4d61a069b9bbe0e7595fbfb7cfbacfd87
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	OLFML3 KCNT2 ROBO1 MMP2 RECK	1.71e-04	177	130	5	43ba6f12c2fb32698a420bf799d46ac1b558f146
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SATB2 OLFML3 SSC5D OCSTAMP	1.71e-04	177	130	5	4a697866ed542d3201714234cee03451adf1dcc9
ToppCell	PBMC-Severe-cDC_11\|Severe / Compartment, Disease Groups and Clusters	WDFY4 F12 SEMA4G SSC5D BMPR1B	1.76e-04	178	130	5	0667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK1 KCNT2 SORCS2 C1R PARP12	1.81e-04	179	130	5	c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK1 KCNT2 SORCS2 C1R PARP12	1.85e-04	180	130	5	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	wk_20-22-Hematologic-Myeloid-pDC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CDH23 SIK1 IRF4 LRRK1 WDFY4	1.90e-04	181	130	5	60607c5ff6d5b1cb416adc034491dca31c41e988
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RDH5 FBXO39 AGBL1	2.00e-04	39	130	3	66fe368f1dfe665c661cf9baf854d12eb28c25b8
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RDH5 FBXO39 AGBL1	2.00e-04	39	130	3	d5b0bcdfb27c881049178079c48deb587a0b2fda
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OLFML3 GPR158 SORCS2 C1R MMP2	2.00e-04	183	130	5	269afec240a756eec3bbae5f30ec784281af3433
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	OLFML3 SSC5D ZNF469 ROBO1 MMP2	2.05e-04	184	130	5	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 SSC5D KCNT2 ROBO1 MMP2	2.05e-04	184	130	5	3bffadb0cb2e0d825bdb6cfc5d23f5436cbc3efd
ToppCell	droplet-Kidney-nan-21m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 SSC5D KCNT2 ROBO1 MMP2	2.10e-04	185	130	5	33cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCell	343B-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	HEATR5A SSC5D P3H1 SORCS2 AGAP3	2.10e-04	185	130	5	1b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 SSC5D KCNT2 ROBO1 MMP2	2.10e-04	185	130	5	9954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCell	343B-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	HEATR5A SSC5D P3H1 SORCS2 AGAP3	2.10e-04	185	130	5	02cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CDH23 OLFML3 SSC5D ROBO1 MMP2	2.10e-04	185	130	5	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 ADCYAP1R1 SSC5D SORCS2 MMP2	2.10e-04	185	130	5	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML3 ADCYAP1R1 SSC5D SORCS2 MMP2	2.10e-04	185	130	5	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 HCN1 ATG14 FANCE JRK	2.16e-04	186	130	5	aa88d9573a237b2b8e6025fee31f69fbce824497
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRL1 OLFML3 PHEX PLAT MMP2	2.16e-04	186	130	5	4e983de6d2515082f9e555f4f949cec84281c140
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BMPR1B MTUS1 MYH14 SORCS2 AGBL1	2.16e-04	186	130	5	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	F12 BMPR1B KCNC3 GPR158 CSMD1	2.16e-04	186	130	5	18fd311252299d6d30ddb32002ed069056108206
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____podocyte-3\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 DNAH10 MST1R FCGBP ROBO1	2.16e-04	186	130	5	29c79b5a29907d4f3f87ad2ca04840c0f15b7d4e
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 HCN1 ATG14 FANCE JRK	2.16e-04	186	130	5	ecc5acd111a6ee50d59544d1bdd7ed94e2812aae
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 AMN SLC6A19 OSBPL6 CSMD1	2.16e-04	186	130	5	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MST1R KCNT2 SORCS2 ROBO1 MMP2	2.21e-04	187	130	5	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCC3 SATB2 AMN SEMA4G MYH14	2.21e-04	187	130	5	1909b65ba23d598e396f77eecae562bb59bf5d5d
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDGFB SIGLEC8 OLFML3 FCGBP CTSB	2.21e-04	187	130	5	2a7226adb4d15b92936603bdf05421c50b21f003
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCYAP1R1 SSC5D KCNT2 SORCS2 MMP2	2.21e-04	187	130	5	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CSMD2 ROBO1 C1R PLAT MMP2	2.27e-04	188	130	5	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	Mesenchymal_cells-Osteoblasts\|World / Lineage and Cell class	SATB2 PHEX ZNF469 P3H1 MMP2	2.27e-04	188	130	5	89f7f5a51be7e046a63e2413f86c521ae4b6718f
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	SSC5D KCNT2 ROBO1 MMP2 PHF21B	2.32e-04	189	130	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCC3 SATB2 AMN SEMA4G MYH14	2.32e-04	189	130	5	8478f433495dabe813146a1f6b00098db8ce775a
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG GPR158 IL17RD AGBL1	2.36e-04	103	130	4	3f4e4600c8a9af3534479ca19905c3d31c4c55bb
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SIGLEC8 SIK1 OLFML3 FCGBP CTSB	2.38e-04	190	130	5	4498705c5c1c7ba88a26fd2f412cf1aadd0f572a
ToppCell	myeloid-pDC\|World / Lineage and Cell class	CDH23 IRF4 WDFY4 PHEX CTSB	2.38e-04	190	130	5	88c42779ce2f817d28e672d83f3f1158581edf73
ToppCell	356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NDUFA4 OLFML3 FCGBP CTSB DNMT1	2.38e-04	190	130	5	d541e076137cf7334bdb0ed69db2f9a27c668c65
ToppCell	Monocytes-Tissue-resident_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PDGFB SIGLEC8 OLFML3 FCGBP MMP2	2.38e-04	190	130	5	07215e8f292cb54c670037aaf28393cddbe5548c
ToppCell	background-Cholangiocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	EPHB6 ABCC3 SLC6A19 CASR CSMD1	2.44e-04	191	130	5	99aa8d685767a72bef9f05e7cc8913126a048c39
ToppCell	Control-B_naive-4\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ABCC3 SSC5D FCGBP ICA1L	2.45e-04	104	130	4	5f72aa686b0fb83d401621e1b9d9c69e56105570
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCC3 PHEX ROBO1 C1R MMP2	2.50e-04	192	130	5	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HEATR5A MTUS1 ICA1L ARAP1 PARP12	2.50e-04	192	130	5	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OLFML3 SSC5D KCNT2 C1R MMP2	2.50e-04	192	130	5	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	Monocytes-Tissue-resident_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	PDGFB SIGLEC8 OLFML3 FCGBP MMP2	2.56e-04	193	130	5	198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Goblet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AMN GMNC BMPR1B FCGBP MYH14	2.56e-04	193	130	5	71bf8fb5314b79cb30f4eb9c8459b21f10cd6d35
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AMN GMNC BMPR1B FCGBP MYH14	2.56e-04	193	130	5	b05e110b13d35d34294357c8e1c4fd23bf4b6c92
ToppCell	VE-pDC-\|VE / Condition, Cell_class and T cell subcluster	CDH23 IRF4 LRRK1 WDFY4 PHEX	2.56e-04	193	130	5	583724de588fcde3aeda056138c522dc0225a387
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	WRN IRF4 WDFY4 DDX10 USP48	2.56e-04	193	130	5	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	VE-pDC\|VE / Condition, Cell_class and T cell subcluster	CDH23 IRF4 LRRK1 WDFY4 PHEX	2.56e-04	193	130	5	bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D KCNT2 ROBO1 C1R MMP2	2.62e-04	194	130	5	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCC3 SATB2 AMN SEMA4G MYH14	2.62e-04	194	130	5	07d8e38cbc2c7f0564c14f7c365f345f901b73b2
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AMN CDH23 IRF4 WDFY4 PHEX	2.62e-04	194	130	5	3f9e4a8e5699bc379e8a0d337e0daef09632e71c
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RDH5 LRRK1 WDFY4 SSC5D BRCA2	2.62e-04	194	130	5	5a048bd2af30975fdc57ff40bc49aa5811c830d8
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D KCNT2 ROBO1 C1R MMP2	2.62e-04	194	130	5	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IRF4 LRRK1 FCGBP PRCP DNMT1	2.62e-04	194	130	5	e56c6e5c9b7d287ae94566b561e21cec2055f83d
Computational	Genes in the cancer module 107.	F12 C1R PLAT MMP2 CTSB	1.03e-04	79	64	5	MODULE_107
Computational	Genes in the cancer module 172.	F12 C1R PLAT MMP2 CTSB	2.57e-04	96	64	5	MODULE_172
Disease	Thromboembolism	F12 LPA PLAT	1.44e-05	12	121	3	C0040038
Disease	Osteosarcoma	WRN BCOR MST1R MMP2	4.19e-05	47	121	4	C0029463
Disease	heart valve disease (is_marker_for)	LRP5 MMP2	4.99e-05	3	121	2	DOID:4079 (is_marker_for)
Disease	Bone marrow hypocellularity	MYSM1 FANCE BRCA2	5.25e-05	18	121	3	C1855710
Disease	Glioblastoma Multiforme	EPHB6 SIK1 MMP2 CTSB RECK	9.67e-05	111	121	5	C1621958
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	PKD1 LRP5	9.95e-05	4	121	2	DOID:898 (is_implicated_in)
Disease	Pancytopenia	MYSM1 FANCE BRCA2	1.63e-04	26	121	3	C0030312
Disease	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1	HCN1 SIK1	2.47e-04	6	121	2	C3463992
Disease	Disorder of eye	MKKS RDH5 CDH23 BCOR LRP5 CPLANE1	2.48e-04	212	121	6	C0015397
Disease	polycystic liver disease (implicated_via_orthology)	PKD1 LRP5	3.46e-04	7	121	2	DOID:0050770 (implicated_via_orthology)
Disease	infertility (implicated_via_orthology)	METTL3 BRCA2	3.46e-04	7	121	2	DOID:5223 (implicated_via_orthology)
Disease	liver cirrhosis (biomarker_via_orthology)	PDGFB MMP2 DNMT1	3.67e-04	34	121	3	DOID:5082 (biomarker_via_orthology)
Disease	Hodgkins lymphoma	POLR1G FCGBP CPLANE1 RTN4RL2	3.68e-04	82	121	4	EFO_0000183
Disease	X-linked infantile spasms	HCN1 SIK1	4.59e-04	8	121	2	C4552072
Disease	leukocyte immunoglobulin-like receptor subfamily B member 4 measurement	CDH23 CTSB	4.59e-04	8	121	2	EFO_0801768
Disease	glucagon-like peptide-1 measurement	CSMD1 AGBL1	7.35e-04	10	121	2	EFO_0008465
Disease	myocardial infarction (is_implicated_in)	WRN F12 LPA PLAT	7.50e-04	99	121	4	DOID:5844 (is_implicated_in)
Disease	Malignant neoplasm of kidney	BCOR BRCA2 HLTF	8.42e-04	45	121	3	C0740457
Disease	intracranial aneurysm (is_implicated_in)	PKD1 MMP2	1.07e-03	12	121	2	DOID:10941 (is_implicated_in)
Disease	Dental enamel hypoplasia	ZMIZ1 MYH14	1.07e-03	12	121	2	EFO_1001304
Disease	cholestasis (biomarker_via_orthology)	ABCC3 PDGFB MMP2	1.08e-03	49	121	3	DOID:13580 (biomarker_via_orthology)
Disease	triglyceride measurement, intermediate density lipoprotein measurement	DNAH10 BRCA2 LPA CTSB	1.15e-03	111	121	4	EFO_0004530, EFO_0008595
Disease	Diverticular Bleeding	BMPR1B GPR158	1.26e-03	13	121	2	C4505353
Disease	intracranial aneurysm (biomarker_via_orthology)	MMP2 CTSB	1.26e-03	13	121	2	DOID:10941 (biomarker_via_orthology)
Disease	Diverticular Diseases	BMPR1B GPR158	1.26e-03	13	121	2	C4317009
Disease	X-24588 measurement	ABCC3 NUMB	1.26e-03	13	121	2	EFO_0800898
Disease	Connective Tissue Diseases	ZNF469 PKD1	1.26e-03	13	121	2	C0009782
Disease	cancer	EPHB6 SATB2 SMARCAL1 IRF4 POLR1G BRCA2 JRK	1.34e-03	400	121	7	MONDO_0004992
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD1 LRP5	1.47e-03	14	121	2	DOID:898 (implicated_via_orthology)
Disease	Fanconi anemia	FANCE BRCA2	1.47e-03	14	121	2	cv:C0015625
Disease	intracranial aneurysm (is_marker_for)	MMP2 CTSB	1.47e-03	14	121	2	DOID:10941 (is_marker_for)
Disease	Myopia	PRSS56 RDH5	1.69e-03	15	121	2	C0027092
Disease	diastolic blood pressure, body mass index	ROBO1 SAYSD1	1.93e-03	16	121	2	EFO_0004340, EFO_0006336
Disease	cardiac troponin T measurement	HCN1 CDH23 CASR NOL10 TMEM131	2.13e-03	219	121	5	EFO_0005043
Disease	hypertrophic cardiomyopathy (is_marker_for)	MMP2 DNMT1	2.18e-03	17	121	2	DOID:11984 (is_marker_for)
Disease	type 2 diabetes mellitus (is_marker_for)	F12 PLAT MMP2 CTSB	2.42e-03	136	121	4	DOID:9352 (is_marker_for)
Disease	response to methotrexate, juvenile idiopathic arthritis	ZMIZ1 CSMD1	2.72e-03	19	121	2	EFO_0002609, GO_0031427
Disease	kidney failure (biomarker_via_orthology)	RHCG PHEX	2.72e-03	19	121	2	DOID:1074 (biomarker_via_orthology)
Disease	Meningioma	PDGFB WRN	2.72e-03	19	121	2	C0025286
Disease	synophrys measurement	IRF4 ERCC6L2 LRP5	2.78e-03	68	121	3	EFO_0007906
Disease	rheumatoid arthritis (is_marker_for)	PDGFB LPA DNMT1	2.89e-03	69	121	3	DOID:7148 (is_marker_for)
Disease	diverticular disease	BABAM2 BMPR1B GPR158 ROBO1 ICA1L	2.94e-03	236	121	5	EFO_0009959
Disease	atherosclerosis (biomarker_via_orthology)	CASR MMP2	3.02e-03	20	121	2	DOID:1936 (biomarker_via_orthology)
Disease	Deep Vein Thrombosis	LPA PLAT	3.33e-03	21	121	2	C0149871
Disease	Venous Thrombosis	LPA PLAT	3.33e-03	21	121	2	C0042487
Disease	progranulin measurement	CDH23 ADGRL1	3.65e-03	22	121	2	EFO_0004625
Disease	Nasopharyngeal carcinoma	MST1R MMP2	3.65e-03	22	121	2	C2931822
Disease	Amphetamine-Related Disorders	PLAT CSMD1 USP48	3.66e-03	75	121	3	C0236733
Disease	Amphetamine Abuse	PLAT CSMD1 USP48	3.66e-03	75	121	3	C0236807
Disease	Amphetamine Addiction	PLAT CSMD1 USP48	3.66e-03	75	121	3	C0236804
Disease	axial length measurement	PRSS56 RDH5 ZNF469	3.95e-03	77	121	3	EFO_0005318
Disease	Craniofacial Abnormalities	SATB2 PHEX BMPR1B MMP2	3.96e-03	156	121	4	C0376634

Protein segments in the cluster

Peptide	Gene	Start	Entry
CIDCDAPNPDWASLN	AGAP3	641	Q96P47
PFIVTSILWDNCNAP	ERVK13-1	61	Q9NX77
PASFDAREQWPQCPT	CTSB	81	P07858
NRFFWQPDPPTCIAA	CSMD1	1436	Q96PZ7
ECEPNFQWSRALPSC	CSMD2	906	Q7Z408
DPAARQFNTLIPWCL	DNMT1	1486	P26358
LGTDWENLPSPRFCD	ATG14	431	Q6ZNE5
ASFQCLPALGLWNPR	ADGRL1	511	O94910
NRQWFSLLPRTPCDD	BAZ2B	1556	Q9UIF8
EPQDWTCRLRQPAFG	CASR	671	P41180
RPSIPNQWQSCEALR	ACVR1C	441	Q8NER5
AEAQPWICAALLQPL	AMN	216	Q9BXJ7
NCWQAAFPDPQLRLE	CFAP161	191	Q6P656
LDSCFSLPNIPRWQP	DENND1C	591	Q8IV53
PSFPNRWSSDECLRQ	BMPR1B	451	O00238
ALDWAIPQQRSSSCP	BCOR	531	Q6W2J9
RLPVANPQACENWLR	C1R	611	P00736
DGANPVWLDPFCRNL	CDH23	3126	Q9H251
DEPWPLQDNASNCLR	AGBL1	581	Q96MI9
LEFEDQPCCPVFRNW	ADAT1	151	Q9BUB4
QCGQLQRLFPWLSPE	ANO8	826	Q9HCE9
LPPDVQRVDAAFNWS	MMP2	561	P08253
PSLEFLRLNANPWAC	RTN4RL2	251	Q86UN3
PQDPLWQCFLESSQS	RECK	256	O95980
QWDTPCPRENAEAAF	OLFML3	311	Q9NRN5
RTQCAADFPWELDPD	P3H1	76	Q32P28
CNHPELFERQETWSP	INO80	816	Q9ULG1
PDLTPCFQNSLLAWV	ABCC3	26	O15438
QADSPCVANWPDLLS	MKKS	481	Q9NPJ1
DLLLQPDNLACKPFW	IL17RD	186	Q8NFM7
WDGPLALCNDRPNKL	IRF4	336	Q15306
LPFVWKPNDNLNCAG	MTUS1	136	Q9ULD2
VSRNNLKVFPDPWAC	LRRK1	411	Q38SD2
FQQPLTSRAEVCPWE	GPR158	1161	Q5T848
REENLQAAPNGPAWC	LONRF1	716	Q17RB8
FWQDLDQPRAIALDP	LRP5	146	O75197
NPPGLLALLDEECWF	MYH14	546	Q7Z406
IDRTNANFLVWPPCV	PDGFB	111	P01127
ADETGLFWRCLPNPT	JRK	186	O75564
EPFSAFCWDQPLAAL	LENG9	121	Q96B70
ELIQPQDQSCWAFLP	FBXO39	6	Q8N4B4
AASAPIWQFEDLVPC	PRCP	201	P42785
SDDCFQQWGVRPRPS	PRCP	391	P42785
LWFLRNLNDPDFNPV	MARCHF6	451	O60337
GFWCQPASQLPRDQL	MSLNL	61	Q96KJ4
WPSLRNLFVPVFLNC	KCNT2	156	Q6UVM3
PAPRWCSFLDNLTEE	NOL10	346	Q9BSC4
DQTSPAPGLRCLNWL	PIK3IP1	36	Q96FE7
APCPDTSNINLWNIL	OSBPL6	561	Q9BZF3
FERCEGSQPWNLTPR	PHKG2	291	P15735
GDSSADRLFPPQWIC	METTL3	361	Q86U44
SCPELFRIFNPDQVW	ADCYAP1R1	76	P41586
ACLTFWEPAEPSQQE	SBF1	81	O95248
CQLLFQNDPWLLPEI	PARP12	141	Q9H0J9
LLQDFPPDCWVSLNE	HCN1	321	O60741
SPNPLLRCAAAESWA	HEATR5A	861	Q86XA9
NLASWNPSNPECLLL	BABAM2	101	Q9NXR7
DSLCPNLIDNGSWPA	BRCA2	551	P51587
PDNLCPFWNKRDDVL	CPLANE1	521	Q9H799
WDCQLALSLPARFQD	FCGBP	591	Q9Y6R7
FSDQCNVPEWLPFAR	CR1L	31	Q2VPA4
ALFANDACGQPVPWE	FAM120C	831	Q9NX05
NRSVCLECPEFQIPW	FASTKD1	666	Q53R41
KPFIAAWNAPTDQCL	HYAL4	46	Q2M3T9
RCSDAEWTAFVPPNV	LPA	1016	P08519
FLAWQSLQPADRLSC	BRF2	231	Q9HAW0
SCWLPLHRAFPQAAN	LYPLA2	146	O95372
AEECRPNSQPWQAGL	KLK9	26	Q9UKQ9
APWRPAADLQDNACR	LAMB4	316	A4D0S4
FPAVNWVLQFDCPED	DDX10	381	Q13206
AQQDLAPDPDAWLRA	FANCE	121	Q9HB96
DPAWNPAAEDQCFDR	HLTF	931	Q14527
LFDPTWNPANDLQAI	ERCC6L2	611	Q5T890
WFNLFADLDPLSNPD	ICA1L	456	Q8NDH6
RFPLCIDPQQQALNW	DNAH10	3431	Q8IVF4
ADCWAQDPHRRPDFA	MAP3K11	356	Q16584
RNPLFCGAENTSLWE	CEBPZ	701	Q03701
AFSLESCQNWLPGEP	PKD1	486	P98161
CRELLAWDPPQELQA	PRSS56	346	P0CW18
SCPSLPDQNNIWIRD	MEIS3P1	91	A6NDR6
CPVDPFEAQWAALEN	NUMB	611	P49757
LPSWLQPERCAVFQC	OIP5	66	O43482
CRNPDNDIRPWCFVL	F12	266	P00748
FNSFQEPLPWSDCPL	SLC6A19	141	Q695T7
FNIPTLCDPANLQWF	TCAIM	386	Q8N3R3
NFPLPDLCSWEEAQL	GMNC	66	A6NCL1
DFPCLDSPQAWLSAI	EPHB6	946	O15197
PTEQLEFNFCLWGRP	PRAMEF22	466	A3QJZ6
LALFNPDVCWDRNNP	NDUFA4	36	O00483
AFLRWLPSLSPDCIN	SMARCAL1	496	Q9NZC9
SANFWFNPLSPPDDC	SORCS2	726	Q96PQ0
ELWLIQAPADFAPEC	POLR1G	41	O15446
NPSPENRTLWENLCT	SATB2	526	Q9UPW6
LVCAVNSNPPARLSW	SIGLEC8	281	Q9NYZ4
DCELQSSLQWPLFFP	SIK1B	406	A0A0B4J2F2
DCELQSSLQWPLFFP	SIK1	406	P57059
ALAPLQAAWDAFSQP	OCSTAMP	26	Q9BR26
GNEWFRCPEALFQPC	POTEI	951	P0CG38
DFLWPAPNEEQVTCL	WRN	526	Q14191
NETALRFCPARPWGQ	SSC5D	376	A1L4H1
TLQACWARLPPATQA	RDH5	221	Q92781
WNILPKCQDQDFLPR	CCDC15	551	Q0P6D6
ADCGAPQPDWASINL	ARAP1	551	Q96P48
SRFPQLNEWCPFAEL	NCAPH2	526	Q6IBW4
LNEWCPFAELVAGQP	NCAPH2	531	Q6IBW4
ALPADTQAWVCSRQP	ZNF444	71	Q8N0Y2
WILSAAHCFQERFPP	PLAT	351	P00750
LLPCDQPSNLARALW	SEMA4G	581	Q9NTN9
NSNCLLSEPPSWRAQ	TEP1	146	Q99973
NPLFLTARANEDPCW	PHF21B	331	Q96EK2
TCAEALPRPNWELAL	TMEM131	1106	Q92545
QQSWLDLQELFPCPV	TRIM75	41	A6NK02
SVDQLCWHPSNPDLF	THOC3	101	Q96J01
QDPAWRAPEFLQTLA	WDFY4	1811	Q6ZS81
FRFACDGWISNNPIP	PHEX	81	P78562
AWLPDISCFNPDELI	TSTD2	146	Q5T7W7
GFLPWTNCLPNTEDI	VRK3	386	Q8IV63
QCEATGNPQPAIFWR	ROBO1	371	Q9Y6N7
AIPLPSCWDQSFLTN	SAYSD1	86	Q9NPB0
LRLPFWGQPSDENCF	RHCG	416	Q9UBD6
DCRNRRPPWSNDNFQ	ZNFX1	111	Q9P2E3
FCVNALAARDPIWAA	ZNF862	201	O60290
QLLACSPAWAPLEEA	ZNF469	2136	Q96JG9
CFPPEQDLRSGNLWI	ZMYM6	1201	O95789
CFDIQWCPRNPAVLS	SEC31A	306	O94979
PNLFQDKNRPCLSNW	USP48	721	Q86UV5
QQCWEADPAVRPTFR	MST1R	1321	Q04912
FLLDNCLGTSQWPPR	USP11	696	P51784
LDWCGDPRAFQRPFE	ZMIZ1	36	Q9ULJ6
DTRRNFCPPNHWLSE	UBE3C	616	Q15386
PSFLPDLNANAAAWI	KCNC3	741	Q14003
PWANLRAADPLNLSF	NLRP13	56	Q86W25
WTPSCLRGRADPNLN	MYSM1	196	Q5VVJ2