Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	zinc ion binding	TRIM43B USP44 PRKCB TRIM43 RBSN TRIM68 MYO9B TRIM38 UBR7 ZNF330 POLR3A	1.46e-07	891	34	11	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	TRIM43B USP44 PRKCB TRIM43 RBSN TRIM68 MYO9B TRIM38 UBR7 ZNF330 POLR3A	2.56e-06	1189	34	11	GO:0046914
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRIM43B TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	1.24e-05	473	34	7	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRIM43B TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	2.06e-05	512	34	7	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRIM43B TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	2.64e-05	532	34	7	GO:0016755
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM43B TRIM43 TRIM68 TRIM38 UBR7 RING1	3.47e-05	372	34	6	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM43B TRIM43 TRIM68 TRIM38 UBR7 RING1	5.06e-05	398	34	6	GO:0061659
GeneOntologyMolecularFunction	acyltransferase activity	TRIM43B TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	2.78e-04	775	34	7	GO:0016746
GeneOntologyMolecularFunction	nuclear androgen receptor binding	PRKCB TRIM68	1.44e-03	33	34	2	GO:0050681
GeneOntologyBiologicalProcess	protein ubiquitination	TRIM43B USP44 FBXO38 TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	3.54e-06	811	33	9	GO:0016567
GeneOntologyBiologicalProcess	post-translational protein modification	TRIM43B USP44 FBXO38 PRKCB TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	4.34e-06	1074	33	10	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	TRIM43B USP44 FBXO38 TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	7.74e-06	893	33	9	GO:0032446
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	TRIM43B USP44 FBXO38 TRIM43 TRIM68 BIRC6 TRIM38 UBR7 RING1	2.06e-05	1009	33	9	GO:0070647
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	PRKCB GNA11	1.91e-04	13	33	2	GO:0007207
HumanPheno	Aplasia/hypoplasia involving bones of the lower limbs	FBXO38 COL6A1 GNA11 UBR7 KDM4B POLR3A	1.50e-05	474	8	6	HP:0006493
Domain	-	TRIM43B USP44 TRIM43 RBSN SPIRE2 TRIM68 TRIM38 UBR7 KDM4B RING1	4.56e-09	449	34	10	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TRIM43B USP44 TRIM43 RBSN SPIRE2 TRIM68 TRIM38 UBR7 KDM4B RING1	5.63e-09	459	34	10	IPR013083
Domain	BBOX	TRIM43B TRIM43 TRIM68 TRIM38	7.28e-06	69	34	4	SM00336
Domain	Butyrophylin	TRIM43B TRIM43 TRIM68 TRIM38	7.71e-06	70	34	4	IPR003879
Domain	-	TRIM43B TRIM43 TRIM68 TRIM38	8.16e-06	71	34	4	4.10.45.10
Domain	Znf_RING_CS	TRIM43B TRIM43 TRIM68 TRIM38 RING1	1.08e-05	163	34	5	IPR017907
Domain	ZF_BBOX	TRIM43B TRIM43 TRIM68 TRIM38	1.31e-05	80	34	4	PS50119
Domain	Znf_B-box	TRIM43B TRIM43 TRIM68 TRIM38	1.38e-05	81	34	4	IPR000315
Domain	SPRY	TRIM43B TRIM43 TRIM68 TRIM38	1.83e-05	87	34	4	SM00449
Domain	SPRY	TRIM43B TRIM43 TRIM68 TRIM38	2.49e-05	94	34	4	PF00622
Domain	SPRY_dom	TRIM43B TRIM43 TRIM68 TRIM38	2.49e-05	94	34	4	IPR003877
Domain	B30.2/SPRY	TRIM43B TRIM43 TRIM68 TRIM38	2.59e-05	95	34	4	IPR001870
Domain	B302_SPRY	TRIM43B TRIM43 TRIM68 TRIM38	2.59e-05	95	34	4	PS50188
Domain	Znf_FYVE_PHD	RBSN SPIRE2 UBR7 KDM4B	1.42e-04	147	34	4	IPR011011
Domain	ZF_RING_1	TRIM43B TRIM43 TRIM68 TRIM38 RING1	1.70e-04	291	34	5	PS00518
Domain	ZF_RING_2	TRIM43B TRIM43 TRIM68 TRIM38 RING1	1.90e-04	298	34	5	PS50089
Domain	RING	TRIM43B TRIM43 TRIM68 TRIM38 RING1	2.12e-04	305	34	5	SM00184
Domain	Znf_RING	TRIM43B TRIM43 TRIM68 TRIM38 RING1	2.88e-04	326	34	5	IPR001841
Domain	zf-B_box	TRIM43 TRIM68 TRIM38	3.02e-04	72	34	3	PF00643
Domain	ConA-like_dom	TRIM43B TRIM43 TRIM68 TRIM38	6.47e-04	219	34	4	IPR013320
Domain	zf-C3HC4	TRIM43 TRIM68 TRIM38 RING1	6.93e-04	223	34	4	PF00097
Domain	PRY	TRIM68 TRIM38	2.65e-03	42	34	2	PF13765
Domain	PRY	TRIM68 TRIM38	3.44e-03	48	34	2	SM00589
Domain	PRY	TRIM68 TRIM38	3.44e-03	48	34	2	IPR006574
Domain	C1_1	PRKCB MYO9B	4.82e-03	57	34	2	PF00130
Domain	ZF_DAG_PE_1	PRKCB MYO9B	6.04e-03	64	34	2	PS00479
Domain	ZF_DAG_PE_2	PRKCB MYO9B	6.04e-03	64	34	2	PS50081
Domain	C1	PRKCB MYO9B	6.23e-03	65	34	2	SM00109
Domain	PE/DAG-bd	PRKCB MYO9B	6.41e-03	66	34	2	IPR002219
Domain	HEAT_REPEAT	UTP20 COPG1	7.19e-03	70	34	2	PS50077
Domain	-	UTP20 COPG1 INSC	7.56e-03	222	34	3	1.25.10.10
Domain	PHD	UBR7 KDM4B	1.14e-02	89	34	2	SM00249
Domain	Znf_PHD	UBR7 KDM4B	1.19e-02	91	34	2	IPR001965
Domain	ARM-like	UTP20 COPG1 INSC	1.28e-02	270	34	3	IPR011989
Domain	ZF_PHD_2	UBR7 KDM4B	1.29e-02	95	34	2	PS50016
Domain	ZF_PHD_1	UBR7 KDM4B	1.32e-02	96	34	2	PS01359
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	PRKCB GNA11	1.51e-04	11	24	2	M47637
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCB GNA11	1.81e-04	12	24	2	M47649
Pathway	KEGG_LONG_TERM_DEPRESSION	PRKCB GNA11 PLA2G2F	2.20e-04	70	24	3	M8232
Pubmed	Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.	PRKCB GNA11	1.39e-05	6	34	2	21190563
Pubmed	Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry.	PRKCB GNA11	2.59e-05	8	34	2	18632858
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM43B TRIM43	9.66e-05	15	34	2	19703589
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	UTP20 DDX49 COPG1 DNAH7	9.89e-05	248	34	4	27926873
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	TRIM43 TRIM68 TRIM38	2.11e-04	118	34	3	19690564
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	COL6A1 ADAM10	2.74e-04	25	34	2	17170699
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UTP20 DDX49 COPG1 BIRC6 MYO9B POLR3A RING1	2.84e-04	1353	34	7	29467282
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	COPG1 BIRC6 MYO9B	3.41e-04	139	34	3	25476789
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	RBSN TRIM68 BIRC6 KDM4B RING1	5.92e-04	709	34	5	22988430
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TRIM43B PRKCB UTP20 COPG1 BIRC6	7.01e-04	736	34	5	29676528
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KDM4B RING1	8.55e-04	44	34	2	24183668
Cytoband	2q11.1	TRIM43B TRIM43	1.99e-04	28	34	2	2q11.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	GNA11 DDX49 MYO9B KDM4B	2.76e-03	797	34	4	chr19p13
Cytoband	1q44	OR2AK2 ZNF695	3.04e-03	110	34	2	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2AK2 ZNF695	4.08e-03	128	34	2	chr1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr2q11	TRIM43B TRIM43	5.77e-03	153	34	2	chr2q11
Cytoband	19p13.3	GNA11 KDM4B	1.34e-02	237	34	2	19p13.3
Cytoband	6p21.3	TRIM38 RING1	1.48e-02	250	34	2	6p21.3
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM43B TRIM43 TRIM68 TRIM38	9.79e-06	95	26	4	59
GeneFamily	Ring finger proteins	TRIM43B TRIM43 TRIM68 TRIM38 RING1	3.97e-05	275	26	5	58
Disease	triacylglycerol 54:5 measurement	PRKCB MMS22L	5.20e-04	32	31	2	EFO_0010423
Disease	health study participation	MMS22L BIRC6 KDM4B	1.11e-03	195	31	3	EFO_0010130
Disease	mean arterial pressure	GNA11 MMS22L MYO9B KDM4B	1.77e-03	499	31	4	EFO_0006340
Disease	interleukin 18 measurement	TMEM174 BIRC6	2.90e-03	76	31	2	EFO_0004581
Disease	body surface area	COL6A1 C12orf60 COPG1 MYO9B	4.41e-03	643	31	4	EFO_0022196
Disease	urinary uromodulin measurement	FBXO38 MYO9B	4.58e-03	96	31	2	EFO_0005663
Disease	status epilepticus (biomarker_via_orthology)	PRKCB ADAM10	4.96e-03	100	31	2	DOID:1824 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MVLKKAVDSLLCSMC	BIRC6	3536	Q9NR09
KELCHVCCMKKMDPS	ADAM10	591	O14672
LCGSIMCKKCMELIS	RBSN	181	Q9H1K0
MSKKICCLMVACAWA	OR2AK2	151	Q8NG84
LSMLEMVKTCCCDKQ	MMS22L	456	Q6ZRQ5
QCTCRKDMVKISMDV	KDM4B	306	O94953
KCDTCMMNVHKRCVM	PRKCB	131	P05771
LNKTECDKQTCMCDK	PLA2G2F	101	Q9BZM2
CDKQTCMCDKNMVLC	PLA2G2F	106	Q9BZM2
CMCDKNMVLCLMNQT	PLA2G2F	111	Q9BZM2
LSETMCTSCMCVKDQ	GPR52	331	Q9Y2T5
MCMECLSRKLKEAVT	FBXO38	51	Q6PIJ6
ILDIIMKMCSCCECK	COL6A1	596	P12109
MMACCLSDEVKESKR	GNA11	6	P29992
KDCSMIKLVDIQIMC	DNAH7	2076	Q8WXX0
KCYRVMDLICEKCMK	ANKMY2	196	Q8IV38
DLKLMTECECMCVLQ	INSC	81	Q1MX18
NTCKTCQILCMMLRK	DDX49	256	Q9Y6V7
ACTFSCMMKFTVKDC	COPG1	721	Q9Y678
CLDMLKNTMTTKECL	RING1	51	Q06587
CLMTINDDSATCKKM	UTP20	2331	O75691
STKKMMEEATCSICL	TRIM38	6	O00635
KMFCDMDKSLLCLLC	TRIM43	101	Q96BQ3
QMICKTCCHIMLSQE	POLR3A	106	O14802
AMSIKILCCADCLMG	RXFP2	451	Q8WXD0
NKVCKTMVICCWMAA	OR6C68	136	A6NDL8
IQKESLCSKVAMAMC	C12orf60	81	Q5U649
KMFCKEDVLIMCEAC	TRIM68	106	Q6AZZ1
CKECGNVSCMSLIMT	ZNF695	186	Q8IW36
CKRAVCTSCSIKMKM	SPIRE2	591	Q8WWL2
CKFKMLSCQLCKESE	TMEM174	91	Q8WUU8
SKLCTCQDCMKMYGD	UBR7	311	Q8N806
KMFCDMDKSLLCLLC	TRIM43B	101	A6NCK2
ICAQCGKTKCMMKSS	ZNF330	66	Q9Y3S2
KLSMCTMDEVCKAQA	USP44	656	Q9H0E7
MDKALLCSVCKMTCH	MYO9B	1656	Q13459