Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesion molecule binding	COL3A1 H1-10 ABCF3 SPTAN1 CKAP5 LRRC59 FNBP1L ITGA9 NRXN3 AHNAK MACF1 PKN2	2.99e-05	599	96	12	GO:0050839
GeneOntologyMolecularFunction	cadherin binding	H1-10 ABCF3 SPTAN1 CKAP5 LRRC59 FNBP1L AHNAK MACF1 PKN2	3.73e-05	339	96	9	GO:0045296
GeneOntologyMolecularFunction	RNA-dependent RNA polymerase activity	POLR2A TERT	6.84e-05	3	96	2	GO:0003968
GeneOntologyMolecularFunction	sphingolipid floppase activity	ABCA1 ABCA2	1.36e-04	4	96	2	GO:0046623
GeneOntologyMolecularFunction	chromatin binding	H1-10 BCAS3 POLR2A CBX4 SBNO2 PARP1 PYGO2 GLYR1 TTC21B WDR13 VCX DNMT1	2.19e-04	739	96	12	GO:0003682
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	SYNJ2 FIG4	3.39e-04	6	96	2	GO:0043813
HumanPheno	Congenital hip dislocation	COL3A1 MYL2 RYR1 IARS2 KMT2D FIG4	1.56e-05	84	34	6	HP:0001374
HumanPheno	Delirium	RYR1 FIG4 DNMT1	3.16e-05	10	34	3	HP:0031258
HumanPheno	Cerebral cortical atrophy	MYO7A MAPT SPTAN1 LRRK2 PDZD7 TRRAP TERT LUZP1 IARS2 KMT2D	5.52e-05	346	34	10	HP:0002120
HumanPheno	Abnormal brainstem morphology	COL3A1 PCLO SPTAN1 LAMA2 TRRAP TERT RYR1 FIG4 MACF1 DNMT1	6.39e-05	352	34	10	HP:0002363
HumanPheno	Atrophy/Degeneration affecting the central nervous system	COL3A1 MYO7A MAPT BCAS3 PCLO SPTAN1 LRRK2 LAMA2 PDZD7 TRRAP TERT PHGDH LUZP1 FRMD4A IARS2 KMT2D FIG4 MACF1 FGF14 DNMT1	6.48e-05	1347	34	20	HP:0007367
HumanPheno	Hallucinations	MYO7A MAPT LRRK2 PDZD7 TRRAP FIG4 DNMT1	6.96e-05	160	34	7	HP:0000738
HumanPheno	Abnormal cerebral cortex morphology	COL3A1 MYO7A MAPT SPTAN1 LRRK2 LAMA2 PDZD7 TRRAP TERT PHGDH LUZP1 IARS2 KMT2D FIG4 MACF1	7.63e-05	801	34	15	HP:0002538
HumanPheno	Atrophy/Degeneration affecting the brainstem	PCLO SPTAN1 TRRAP DNMT1	1.28e-04	40	34	4	HP:0007366
HumanPheno	Frog-leg posture	POLR2A RYR1	1.29e-04	3	34	2	HP:0031139
HumanPheno	Cerebral hypoplasia	MYO7A MAPT BCAS3 PCLO SPTAN1 LRRK2 PDZD7 TRRAP TERT PHGDH LUZP1 IARS2 KMT2D FIG4 DNMT1	1.41e-04	844	34	15	HP:0006872
Domain	VCX_VCY	VCX2 VCX3A VCX3B VCX	3.85e-09	5	100	4	PF15231
Domain	VCX/VCY1	VCX2 VCX3A VCX3B VCX	3.85e-09	5	100	4	IPR026653
Domain	SH3	MPP2 MYO7A SPTAN1 FNBP1L SAMSN1 MACF1 FYB1	1.62e-04	216	100	7	PS50002
Domain	SH3_domain	MPP2 MYO7A SPTAN1 FNBP1L SAMSN1 MACF1 FYB1	1.81e-04	220	100	7	IPR001452
Domain	Syja_N	SYNJ2 FIG4	2.81e-04	5	100	2	PF02383
Domain	SAC	SYNJ2 FIG4	2.81e-04	5	100	2	PS50275
Domain	SAC_dom	SYNJ2 FIG4	2.81e-04	5	100	2	IPR002013
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	TRRAP TERT KMT2D PYGO2	8.59e-06	26	72	4	MM14793
Pathway	BIOCARTA_PDZS_PATHWAY	PCLO SPTAN1 NRXN3	9.87e-05	18	72	3	M22001
Pubmed	A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.	VCX2 VCX3A VCX3B VCX	6.97e-11	4	102	4	10903929
Pubmed	A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.	VCX2 VCX3A VCY VCX	3.48e-10	5	102	4	10607842
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ABCF3 MAPT BCAS3 SPTAN1 CKAP5 YTHDC2 LRRC59 FNBP1L LUZP1 SYNJ2 RBM19 AHNAK OTUD4 MACF1 PKN2	3.38e-09	724	102	15	36232890
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	H1-10 EME1 ARID4A MAPT SPTAN1 POLR2A CKAP5 YTHDC2 TRRAP KMT2D OTUD4 DYNC1LI1 UTP20 PKN2 DNMT1	8.25e-09	774	102	15	15302935
Pubmed	Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.	VCX2 VCX3A VCX3B	2.45e-08	3	102	3	18076704
Pubmed	Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.	MAPT LRRK2 FGF14	2.45e-08	3	102	3	30571694
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ABCF3 ARID4A BCAS3 POLR2A CKAP5 FNBP1L DRAP1 TRRAP YARS1 IARS2 KMT2D GLYR1 CFDP1 UTP20 QSER1	3.16e-08	857	102	15	25609649
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	H1-10 ABCF3 SPTAN1 POLR2A CKAP5 TRRAP PHGDH LUZP1 PARP1 RBM19 GLYR1 AHNAK DYNC1LI1 MACF1 UTP20 PKN2 WDR13 DNMT1	7.61e-08	1353	102	18	29467282
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAPT BCAS3 SPTAN1 CKAP5 CBX4 RAB11FIP1 LUZP1 DENND1B SYNJ2 AHNAK OTUD7A MACF1 RASSF8 DNMT1	2.32e-07	861	102	14	36931259
Pubmed	A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.	VCX3B VCY VCX	4.87e-07	6	102	3	17342728
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	H1-10 SPTAN1 POLR2A CKAP5 YTHDC2 TRRAP IARS2 GLYR1 AHNAK MACF1 UTP20 DNMT1	5.04e-07	653	102	12	22586326
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	H1-10 ABCA2 MYL2 PCLO SPTAN1 POLR2A LRRC59 PHGDH RYR1 PARP1 IARS2 AHNAK MACF1	7.19e-07	807	102	13	30575818
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	COL3A1 H1-10 SPTAN1 CKAP5 YTHDC2 LRRC59 PHGDH YARS1 LUZP1 PARP1 IARS2 RBM19 GLYR1 AHNAK UTP20 DNMT1	7.86e-07	1257	102	16	36526897
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	H1-10 ABCF3 SPTAN1 CKAP5 LRRC59 FNBP1L LUZP1 SYNJ2 AHNAK MACF1 PKN2	8.87e-07	565	102	11	25468996
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	H1-10 EME1 HIF1A ARID4A POLR2A CKAP5 LRRC59 CBX4 TRRAP PARP1 KMT2D GLYR1 AHNAK UTP20 QSER1 DNMT1	1.15e-06	1294	102	16	30804502
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	MPP2 ABCF3 SPTAN1 CKAP5 YTHDC2 PHGDH PARP1 AHNAK DYNC1LI1 MACF1 PKN2	1.18e-06	582	102	11	20467437
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIF1A MAPT BCAS3 FNBP1L CCDC57 TRRAP DNAH14 SBNO2 TSC22D1 DENND1B SYNJ2 GLYR1 TTC21B KNDC1 MACF1 QSER1 WDR13	1.52e-06	1489	102	17	28611215
Pubmed	Genome-wide association study of periodontal pathogen colonization.	TPD52L3 OTOF GLDC PKN2	2.06e-06	31	102	4	22699663
Pubmed	Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.	TRRAP KMT2D PYGO2	2.90e-06	10	102	3	20937768
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	POLR2A CKAP5 YTHDC2 LRRC59 PHGDH PARP1 IARS2 AHNAK CFDP1 MACF1 PKN2 HERC4 DNMT1	3.59e-06	934	102	13	33916271
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	H1-10 ABCF3 SPTAN1 POLR2A MRPL54 CKAP5 LRRC59 FNBP1L PHGDH YARS1 PARP1 RBM19 AHNAK MACF1 PKN2 DNMT1	3.63e-06	1415	102	16	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	H1-10 PCLO SPTAN1 POLR2A CKAP5 YTHDC2 LRRC59 PHGDH YARS1 PARP1 IARS2 RBM19 GLYR1 DYNC1LI1 UTP20 DNMT1	3.96e-06	1425	102	16	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MPP2 MYO7A MAPT BCAS3 PCLO SPTAN1 CKAP5 YTHDC2 LRRC59 PHGDH YARS1 LUZP1 PARP1 KNDC1 OTUD4 MACF1	4.18e-06	1431	102	16	37142655
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SPTAN1 POLR2A TRRAP PHGDH LUZP1 KMT2D AHNAK PKN2 QSER1 DNMT1	5.14e-06	549	102	10	38280479
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MPP2 MAPT BCAS3 PCLO SPTAN1 CKAP5 LRRC59 PHGDH YARS1 FRMD4A GLYR1 KNDC1 DYNC1LI1 MACF1	6.14e-06	1139	102	14	36417873
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	H1-10 HIF1A SPTAN1 POLR2A CKAP5 LRRC59 PHGDH PARP1 DNMT1	6.32e-06	441	102	9	31239290
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	COL3A1 SPTAN1 CKAP5 PARP1 GLYR1 AHNAK MACF1 DNMT1	6.38e-06	332	102	8	37433992
Pubmed	[Role of poly (ADP-ribose) polymerase 1 on DNA methylation variation induced by B(a)P in human bronchial epithelial cell].	PARP1 DNMT1	8.52e-06	2	102	2	21756783
Pubmed	ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease.	ABCA1 ABCA2	8.52e-06	2	102	2	15649702
Pubmed	The age at motor symptoms onset in LRRK2-associated Parkinson's disease is affected by a variation in the MAPT locus: a possible interaction.	MAPT LRRK2	8.52e-06	2	102	2	21898123
Pubmed	Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.	VCX3A VCX3B	8.52e-06	2	102	2	19812318
Pubmed	Caspase activation precedes and leads to tangles.	MAPT FGF14	8.52e-06	2	102	2	20357768
Pubmed	ABC transporters: from microorganisms to man.	ABCA1 ABCA2	8.52e-06	2	102	2	1282354
Pubmed	LRRK2 Promotes Tau Accumulation, Aggregation and Release.	MAPT LRRK2	8.52e-06	2	102	2	26014385
Pubmed	Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model.	MAPT LRRK2	8.52e-06	2	102	2	33007689
Pubmed	Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.	MAPT FGF14	8.52e-06	2	102	2	24278327
Pubmed	A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.	YARS1 PARP1	8.52e-06	2	102	2	25533949
Pubmed	Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.	MAPT FGF14	8.52e-06	2	102	2	21854751
Pubmed	Oligomeric tau-targeted immunotherapy in Tg4510 mice.	MAPT FGF14	8.52e-06	2	102	2	28655349
Pubmed	Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).	HIF1A TERT	8.52e-06	2	102	2	15199161
Pubmed	Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.	HIF1A PARP1	8.52e-06	2	102	2	18314489
Pubmed	Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.	PARP1 DNMT1	8.52e-06	2	102	2	29497996
Pubmed	Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.	MAPT FGF14	8.52e-06	2	102	2	30616676
Pubmed	Characteristics of TBS-extractable hyperphosphorylated tau species: aggregation intermediates in rTg4510 mouse brain.	MAPT FGF14	8.52e-06	2	102	2	22941973
Pubmed	Trans-synaptic spread of tau pathology in vivo.	MAPT FGF14	8.52e-06	2	102	2	22312444
Pubmed	Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.	MAPT FGF14	8.52e-06	2	102	2	29358399
Pubmed	Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1.	PARP1 DNMT1	8.52e-06	2	102	2	33039802
Pubmed	MAPT IVS1+124 C>G modifies risk of LRRK2 G2385R for Parkinson's disease in Chinese individuals.	MAPT LRRK2	8.52e-06	2	102	2	24559644
Pubmed	Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs.	MAPT FGF14	8.52e-06	2	102	2	19665462
Pubmed	Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.	MAPT FGF14	8.52e-06	2	102	2	35613261
Pubmed	Tau suppression in a neurodegenerative mouse model improves memory function.	MAPT FGF14	8.52e-06	2	102	2	16020737
Pubmed	Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.	MAPT FGF14	8.52e-06	2	102	2	27030011
Pubmed	Tau promotes neurodegeneration via DRP1 mislocalization in vivo.	MAPT FGF14	8.52e-06	2	102	2	22920254
Pubmed	Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage.	HIF1A LRRK2	8.52e-06	2	102	2	30420654
Pubmed	Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart.	HIF1A MYL2	8.52e-06	2	102	2	15132980
Pubmed	Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.	MAPT FGF14	8.52e-06	2	102	2	37192625
Pubmed	Cbx4 governs HIF-1α to involve in Th9 cell differentiation promoting asthma by its SUMO E3 ligase activity.	HIF1A CBX4	8.52e-06	2	102	2	37348765
Pubmed	Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.	MAPT FGF14	8.52e-06	2	102	2	28111080
Pubmed	Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.	VCX3B VCX	8.52e-06	2	102	2	12862317
Pubmed	Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2.	ABCA1 ABCA2	8.52e-06	2	102	2	10970803
Pubmed	LRRK2 phosphorylates novel tau epitopes and promotes tauopathy.	MAPT LRRK2	8.52e-06	2	102	2	24113872
Pubmed	Tau protein aggregation is associated with cellular senescence in the brain.	MAPT FGF14	8.52e-06	2	102	2	30126037
Pubmed	Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.	ABCA1 PARP1	8.52e-06	2	102	2	27026705
Pubmed	Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.	MAPT FGF14	8.52e-06	2	102	2	25151619
Pubmed	Pathogenic tau does not drive activation of the unfolded protein response.	MAPT FGF14	8.52e-06	2	102	2	31053641
Pubmed	Cloning of two novel ABC transporters mapping on human chromosome 9.	ABCA1 ABCA2	8.52e-06	2	102	2	8088782
Pubmed	HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia.	HIF1A KCNK5	8.52e-06	2	102	2	25305321
Pubmed	RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cells.	HIF1A TERT	8.52e-06	2	102	2	20643931
Pubmed	[Suppressing poly(ADP-ribose)polymerase-1 inhibits tau phosphorylation in HEK293/tau441 cells].	MAPT PARP1	8.52e-06	2	102	2	22193445
Pubmed	P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway.	MAPT FGF14	8.52e-06	2	102	2	25319522
Pubmed	HIF-1α-Mediated Telomerase Reverse Transcriptase Activation Inducing Autophagy Through Mammalian Target of Rapamycin Promotes Papillary Thyroid Carcinoma Progression During Hypoxia Stress.	HIF1A TERT	8.52e-06	2	102	2	32772829
Pubmed	Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.	MAPT FGF14	8.52e-06	2	102	2	26538322
Pubmed	Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy.	MAPT FGF14	8.52e-06	2	102	2	33242304
Pubmed	PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress.	HIF1A PARP1	8.52e-06	2	102	2	18459142
Pubmed	RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.	HIF1A YTHDC2	8.52e-06	2	102	2	26996300
Pubmed	A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.	VCY VCX	8.52e-06	2	102	2	24970476
Pubmed	PDZD7-MYO7A complex identified in enriched stereocilia membranes.	MYO7A PDZD7	8.52e-06	2	102	2	27525485
Pubmed	Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.	MAPT FGF14	8.52e-06	2	102	2	16651626
Pubmed	Glycine decarboxylase and HIF-1α expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer.	HIF1A GLDC	8.52e-06	2	102	2	28062918
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	ABCA1 IKZF2 MYO7A PDZD7	8.65e-06	44	102	4	27534441
Pubmed	Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.	MAPT TERT IVD	1.09e-05	15	102	3	23583980
Pubmed	Identification of cAMP analogue inducible genes in RAW264 macrophages.	ABCA1 LRRK2 SLC23A2	1.33e-05	16	102	3	11004510
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	SPTAN1 POLR2A RAB11FIP1 TRRAP PHGDH ITIH4 YARS1 PARP1 RGS6 FIG4 GLYR1	1.38e-05	754	102	11	35906200
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	ARID4A POLR2A CBX4 AHNAK QSER1	1.88e-05	110	102	5	26841866
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PCLO SPTAN1 LUZP1 AHNAK DYNC1LI1 MACF1 PKN2	2.00e-05	281	102	7	28706196
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	H1-10 SPTAN1 TRRAP YARS1 PARP1 GLYR1 AHNAK DYNC1LI1	2.19e-05	394	102	8	27248496
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	H1-10 MAPT POLR2A YTHDC2 CBX4 RAB11FIP1 TRRAP ITIH4 LUZP1 MACF1 HSD11B1 WDR13 PADI2	2.38e-05	1116	102	13	31753913
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	LRRK2 TERT FIG4 DYNC1LI1	2.44e-05	57	102	4	27433848
Pubmed	LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.	MAPT LRRK2	2.55e-05	3	102	2	22303461
Pubmed	Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology.	MAPT FGF14	2.55e-05	3	102	2	26949217
Pubmed	Protein interactions with myocilin.	MYL2 ITGA9	2.55e-05	3	102	2	11773029
Pubmed	Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation.	PARP1 FGF4	2.55e-05	3	102	2	23939864
Pubmed	LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.	MAPT LRRK2	2.55e-05	3	102	2	26268594
Pubmed	P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.	MAPT FGF14	2.55e-05	3	102	2	37716378
Pubmed	PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation.	PARP1 FGF4	2.55e-05	3	102	2	19531481
Pubmed	RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.	RGS6 DNMT1	2.55e-05	3	102	2	27713144
Pubmed	EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis.	HIF1A TERT	2.55e-05	3	102	2	21156006
Pubmed	Regulation of 11β-HSD1 expression during adipose tissue expansion by hypoxia through different activities of NF-κB and HIF-1α.	HIF1A HSD11B1	2.55e-05	3	102	2	23512810
Pubmed	RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.	RGS6 DNMT1	2.55e-05	3	102	2	14734556
Pubmed	Hsp90 activator Aha1 drives production of pathological tau aggregates.	MAPT FGF14	2.55e-05	3	102	2	28827321
Interaction	H2BC9 interactions	H1-10 EME1 HIF1A PCLO SPTAN1 POLR2A CKAP5 LAMA2 PDZD7 TRRAP PARP1 OTOF SYNJ2 AHNAK CFDP1 SLC23A2 DNMT1	6.68e-11	446	100	17	int:H2BC9
Interaction	H2BC21 interactions	H1-10 EME1 TPD52L3 ARID4A PCLO POLR2A CBX4 DRAP1 PARP1 RGS6 OTOF GLYR1 AHNAK CFDP1 QSER1 FYB1	3.12e-07	696	100	16	int:H2BC21
Interaction	YWHAH interactions	ABCA2 MAPT BCAS3 SPTAN1 LRRK2 CKAP5 CBX4 SOCS6 SAMSN1 RAB11FIP1 LUZP1 FRMD4A IARS2 DENND1B SYNJ2 AHNAK OTUD7A MACF1 RASSF8 DNMT1	3.95e-07	1102	100	20	int:YWHAH
Interaction	YWHAG interactions	MAPT BCAS3 SPTAN1 LRRK2 CKAP5 CBX4 SOCS6 SAMSN1 RAB11FIP1 TRRAP LUZP1 FRMD4A IARS2 DENND1B SYNJ2 OTUD7A MACF1 PKN2 RASSF8 GAREM1 DNMT1	6.64e-07	1248	100	21	int:YWHAG
Interaction	H3C1 interactions	H1-10 MAPT BCAS3 SPTAN1 POLR2A LRRK2 LAMA2 LRRC59 CBX4 TRRAP PARP1 KMT2D GLYR1 AHNAK CFDP1 DNMT1	8.84e-06	901	100	16	int:H3C1
Interaction	YWHAZ interactions	MAPT SPTAN1 LRRK2 CKAP5 CBX4 SAMSN1 RAB11FIP1 TERT LUZP1 IVD DENND1B KCNK5 OTUD4 DYNC1LI1 MACF1 RASSF8 PADI2 GAREM1 DNMT1	2.28e-05	1319	100	19	int:YWHAZ
Interaction	CTNNB1 interactions	HIF1A ABCF3 MYO7A MAPT SPTAN1 POLR2A LRRK2 TRRAP PHGDH PARP1 TSC22D1 KMT2D PYGO2 GLDC RASSF8 DNMT1	3.55e-05	1009	100	16	int:CTNNB1
Interaction	SFN interactions	HIF1A MAPT SPTAN1 LRRK2 LRRC59 CBX4 SAMSN1 RAB11FIP1 LUZP1 DENND1B SYNJ2 MACF1 PKN2	3.76e-05	692	100	13	int:SFN
Interaction	H2BC11 interactions	H1-10 MAPT PCLO POLR2A CKAP5 DTX3L CFDP1	3.96e-05	186	100	7	int:H2BC11
Interaction	H2AC4 interactions	H1-10 MAPT SPTAN1 DTX3L CBX4 PARP1 KMT2D RBM19 GLYR1 CFDP1 DYNC1LI1	4.24e-05	506	100	11	int:H2AC4
Interaction	AGAP2 interactions	PCLO SPTAN1 LUZP1 AHNAK DYNC1LI1 MACF1 PKN2	8.51e-05	210	100	7	int:AGAP2
Interaction	RGS6 interactions	TRRAP RGS6 DNMT1	9.16e-05	18	100	3	int:RGS6
Interaction	HNRNPAB interactions	MAPT PCLO LRRK2 HTRA4 TRRAP DNAH14 PARP1 GLDC AHNAK	9.60e-05	371	100	9	int:HNRNPAB
Interaction	GSK3B interactions	HIF1A MAPT LRRK2 YTHDC2 LRRC59 DTX3L PHGDH YARS1 LUZP1 PARP1 IARS2 MACF1 RASSF8 DNMT1	9.61e-05	868	100	14	int:GSK3B
Interaction	H1-3 interactions	H1-10 LRRK2 TRRAP PHGDH IVD PARP1 RBM19 GLYR1	1.01e-04	291	100	8	int:H1-3
Interaction	YWHAQ interactions	MAPT LRRK2 CBX4 SOCS6 SAMSN1 RAB11FIP1 TERT LUZP1 IARS2 DENND1B SYNJ2 OTUD7A MACF1 RASSF8 GAREM1 DNMT1	1.19e-04	1118	100	16	int:YWHAQ
Interaction	ERG interactions	SPTAN1 POLR2A PARP1 KMT2D PYGO2 QSER1 WDR13	1.24e-04	223	100	7	int:ERG
Interaction	MEX3A interactions	COL3A1 SPTAN1 CKAP5 LAMA2 PARP1 GLYR1 AHNAK MACF1 DNMT1	1.25e-04	384	100	9	int:MEX3A
Interaction	YWHAE interactions	MAPT SPTAN1 LRRK2 CKAP5 CBX4 SAMSN1 RAB11FIP1 LUZP1 FRMD4A IARS2 DENND1B SYNJ2 DYNC1LI1 MACF1 RASSF8 GAREM1 DNMT1	1.40e-04	1256	100	17	int:YWHAE
Interaction	MAPRE3 interactions	MAPT CKAP5 LUZP1 IARS2 SYNJ2 MACF1 RASSF8	1.50e-04	230	100	7	int:MAPRE3
GeneFamily	Variable charge X/Y family	VCX2 VCX3A VCX3B VCY VCX	5.20e-12	6	72	5	368
GeneFamily	PDZ domain containing	MPP2 PCLO PDZD7 HTRA4 AHNAK	3.50e-04	152	72	5	1220
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA2	1.38e-03	14	72	2	805
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PCLO PARP1	1.59e-03	15	72	2	26
GeneFamily	OTU domain containing	OTUD7A OTUD4	2.05e-03	17	72	2	669
GeneFamily	Aminoacyl tRNA synthetases, Class I	YARS1 IARS2	2.56e-03	19	72	2	131
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_DN	H1-10 HIF1A VCX2 VCX3A BCAS3 TERT OTUD7A VCX	1.23e-06	203	101	8	M15912
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	HIF1A ARID4A CKAP5 FNBP1L SOCS6 TRRAP SYNJ2 OTUD4 MACF1 UTP20 PKN2 SETD3 SLC23A2 HERC4	5.20e-06	856	101	14	M4500
Coexpression	BERNARD_PPAPDC1B_TARGETS_UP	MYO7A TRRAP FRMD4A DENND1B	1.24e-05	37	101	4	M15315
Coexpression	GSE17186_CD21LOW_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_UP	ARID4A BCAS3 RAB11FIP1 FRMD4A DYNC1LI1 WDR13 PADI2	1.27e-05	200	101	7	M7192
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	ARID4A MYO7A SPTAN1 YTHDC2 SAMSN1 DRAP1 LUZP1 SBNO2 PARP1 KMT2D DENND1B AHNAK GLIPR2 OTUD4 MACF1 FYB1 NLRC3 DNMT1	1.45e-05	1492	101	18	M40023
Coexpression	KAYO_CALORIE_RESTRICTION_MUSCLE_UP	COL3A1 MAPT SPTAN1 LAMA2 RGS6	3.22e-05	94	101	5	M7013
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SAMSN1 HTRA4 FRMD4A FIG4 GLIPR2 TPRG1 MS4A14 FYB1	1.37e-08	192	101	8	bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	ABCA1 HTRA4 GTDC1 GLIPR2 TPRG1 FYB1 SLC23A2	2.83e-07	192	101	7	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	Myeloid-D_(Mast_cell)\|World / shred on cell class and cell subclass (v4)	IKZF2 SAMSN1 OTUD7A GLIPR2 FYB1 PADI2	5.24e-07	130	101	6	574e262eb4ed2d69c3da68be061cebac9fefc29e
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HIF1A MYO7A MAPT RAB11FIP1 KCNK5 HSD11B1	3.06e-06	176	101	6	56c055488e34605d32562571a2fee621b47c9441
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 AHNAK GLIPR2 HSD11B1 FYB1 PADI2	3.17e-06	177	101	6	dba8b30a311051c22ca5f77697f5dbf9423c3ba0
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HIF1A ABCA1 SAMSN1 RYR1 FRMD4A GLIPR2	4.48e-06	188	101	6	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	PCLO LRRK2 DNAH14 PHGDH NRXN3 GAREM1	4.48e-06	188	101	6	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	HTRA4 FRMD4A FIG4 GLIPR2 TPRG1 MS4A14	4.91e-06	191	101	6	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HIF1A ABCA1 HTRA4 GTDC1 FRMD4A TPRG1	5.52e-06	195	101	6	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	ABCA1 GTDC1 FRMD4A FIG4 GLIPR2 TPRG1	5.52e-06	195	101	6	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	PND01-Mesenchymal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 MAPT DRAP1 TSC22D1 MACF1 HSD11B1	5.86e-06	197	101	6	292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	SAMSN1 GTDC1 FRMD4A GLIPR2 TPRG1 FYB1	6.03e-06	198	101	6	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	Neuron\|World / Primary Cells by Cluster	ARID4A MAPT PCLO SPTAN1 FNBP1L TSC22D1	6.21e-06	199	101	6	1f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCell	Neuron-Postmitotic\|World / Primary Cells by Cluster	ARID4A MAPT PCLO SPTAN1 FNBP1L TSC22D1	6.21e-06	199	101	6	1973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	ARID4A MAPT PCLO SPTAN1 FNBP1L TSC22D1	6.21e-06	199	101	6	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOCS6 SAMSN1 ITIH4 RYR1 FRMD4A FYB1	6.21e-06	199	101	6	e245851a5bddf56f7e13a7fb7c5fda2fd275dae3
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	POLR2A SAMSN1 RAB11FIP1 CCDC57 HERC4	6.24e-06	114	101	5	670c9802a59b39241abf6f2c12a3d1844c7db5e5
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SOCS6 SAMSN1 RYR1 FRMD4A PKN2 FYB1	6.39e-06	200	101	6	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SOCS6 SAMSN1 RYR1 FRMD4A PKN2 FYB1	6.39e-06	200	101	6	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SOCS6 SAMSN1 RYR1 FRMD4A PKN2 FYB1	6.39e-06	200	101	6	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA1 MYO7A SAMSN1 HTRA4 FRMD4A MS4A14	6.39e-06	200	101	6	78d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SOCS6 SAMSN1 RYR1 FRMD4A PKN2 FYB1	6.39e-06	200	101	6	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SOCS6 SAMSN1 RYR1 FRMD4A PKN2 FYB1	6.39e-06	200	101	6	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SOCS6 SAMSN1 RYR1 FRMD4A PKN2 FYB1	6.39e-06	200	101	6	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL3A1 LAMA2 OTUD7A ATP1A4 GAREM1	4.06e-05	168	101	5	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	Bronchial_Biopsy-Immune-T_and_NK\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	COL3A1 MYO7A LAMA2 ATP1A4 NLRC3	4.06e-05	168	101	5	435b2f238fbb3f50427e8cdecf2220615015153c
ToppCell	3'-Adult-Distal_Rectal-Epithelial-mature_enterocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSC22D1 NRXN3 AHNAK KNDC1 PADI2	4.41e-05	171	101	5	0de81d12a8000f2c59cdb214e67dc526d18098fe
ToppCell	3'-Adult-Distal_Rectal-Epithelial-mature_enterocytic-Colonocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSC22D1 NRXN3 AHNAK KNDC1 PADI2	4.41e-05	171	101	5	0597339618fb4d416d55c538eceb353218a55002
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HIF1A ABCA1 MYO7A SAMSN1 PADI2	4.41e-05	171	101	5	5e93c76ee60f9d0590ebb140812653a5e1369417
ToppCell	facs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 TSC22D1 AHNAK FYB1 PADI2	4.66e-05	173	101	5	ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IKZF2 SAMSN1 GLIPR2 FYB1 PADI2	4.66e-05	173	101	5	8ca650542655c27516029e5bace97ff1b9dcc256
ToppCell	facs-Marrow-T-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 TSC22D1 AHNAK FYB1 PADI2	4.66e-05	173	101	5	19a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IKZF2 SAMSN1 GLIPR2 FYB1 PADI2	4.66e-05	173	101	5	4282b47b33325472f52a4085986988911a372ed8
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 ITGA9 TSC22D1 NRXN3 OTOF	4.79e-05	174	101	5	c529f3674b784f872f4387ffdeb46aecb619976b
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL3A1 IVD TSC22D1 MACF1 HSD11B1	4.79e-05	174	101	5	3c47d069bd836599a8d40eae485c23d4d3487517
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 SAMSN1 PHGDH GLIPR2 PADI2	5.06e-05	176	101	5	dff11730f26b4b7d26ee83b665d0284bc847cac0
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IKZF2 DTX3L AHNAK MACF1 FYB1	5.20e-05	177	101	5	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IKZF2 DTX3L AHNAK MACF1 FYB1	5.20e-05	177	101	5	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	IKZF2 DTX3L AHNAK MACF1 FYB1	5.20e-05	177	101	5	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IKZF2 DTX3L AHNAK MACF1 FYB1	5.20e-05	177	101	5	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IKZF2 DTX3L AHNAK MACF1 FYB1	5.20e-05	177	101	5	d5aeda113afaa2425874394610344570c9078478
ToppCell	facs-Brain_Myeloid-Striatum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 HIF1A ABCA1 SAMSN1 MACF1	5.20e-05	177	101	5	efb1990fd1d216f64261e81017299783afb24a1e
ToppCell	droplet-Tongue-nan-24m-Myeloid-basal_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMSN1 GLIPR2 HSD11B1 FYB1 PADI2	5.34e-05	178	101	5	9423e209de94d26e96117581c95dc069850225d3
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO RYR1 NRXN3 OTOF NLRC3	5.34e-05	178	101	5	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 SAMSN1 PHGDH GLIPR2 PADI2	5.34e-05	178	101	5	00a5d8f47373be4792bf53914db63a1aedc2d77a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO RYR1 NRXN3 OTOF NLRC3	5.34e-05	178	101	5	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	3'-Adult-Appendix-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAMSN1 FRMD4A RBM19 FYB1 SLC23A2	5.48e-05	179	101	5	2285e3a9018a60d7f6e974fee46b6f61d39aa76f
ToppCell	droplet-Tongue-nan-24m-Myeloid-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMSN1 GLIPR2 HSD11B1 FYB1 PADI2	5.48e-05	179	101	5	1b079d80f789473701c781f3431ad306e9766797
ToppCell	3'-Adult-Appendix-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAMSN1 FRMD4A RBM19 FYB1 SLC23A2	5.48e-05	179	101	5	0b0f27d7c5cc5ae7618d887dcfa7219df8ff1935
ToppCell	3'-Adult-Appendix-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAMSN1 FRMD4A RBM19 FYB1 SLC23A2	5.48e-05	179	101	5	63bc819df62b1f8f37bf1f17bdd4fcc161886923
ToppCell	RA-16._Neuronal\|RA / Chamber and Cluster_Paper	IKZF2 FRMD4A NRXN3 AHNAK KCNK5	5.63e-05	180	101	5	5842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRK2 RAB11FIP1 NRXN3 HSD11B1 GAREM1	5.78e-05	181	101	5	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	RA-16._Neuronal\|World / Chamber and Cluster_Paper	IKZF2 FRMD4A NRXN3 AHNAK KCNK5	5.78e-05	181	101	5	7d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IKZF2 SAMSN1 OTUD7A FYB1 NLRC3	5.93e-05	182	101	5	09d0793245d3d77ab5fc384c0b62637f736da50b
ToppCell	BAL-Control-Myeloid-Macrophage\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIF1A ABCA1 MYO7A HTRA4 ATP1A4	6.09e-05	183	101	5	8e9d45c96b44558158e3d59613f64a73d5390c19
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIF1A ABCA1 MYO7A HTRA4 ATP1A4	6.09e-05	183	101	5	0408d991ddb639594b45d5cb2432dd29289167b1
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIF1A ABCA1 MYO7A HTRA4 ATP1A4	6.09e-05	183	101	5	79f05b8a967124d831b0baef137e30659f5917a7
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	IKZF2 DTX3L AHNAK MACF1 FYB1	6.09e-05	183	101	5	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HIF1A ABCA1 MYO7A HTRA4 ATP1A4	6.25e-05	184	101	5	92202e1cd0bba1ce4b061ebcb8a2af5bb590542a
ToppCell	BAL-Control-Myeloid-Macrophage\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	HIF1A ABCA1 MYO7A HTRA4 ATP1A4	6.25e-05	184	101	5	7331535d469453a5264dcb0270a97f63d3b55201
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	HIF1A ABCA1 MYO7A HTRA4 ATP1A4	6.25e-05	184	101	5	337e38a6b2b6770cc992d88b006829f194841b10
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RGS6 DENND1B FGF14 RASSF8 PADI2	6.41e-05	185	101	5	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABCA1 SAMSN1 RYR1 FRMD4A FYB1	6.41e-05	185	101	5	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	H1-10 PCLO LRRK2 AHNAK C18orf63	6.57e-05	186	101	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	P15-Mesenchymal\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL3A1 LAMA2 TSC22D1 MACF1 HSD11B1	6.91e-05	188	101	5	f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IKZF2 SAMSN1 DENND1B FYB1 NLRC3	6.91e-05	188	101	5	ab95a97db1a84bf3e53a4616a83ee81a6ce5ec12
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	COL3A1 LAMA2 TSC22D1 MACF1 HSD11B1	7.09e-05	189	101	5	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 MPP2 MAPT LAMA2 HSD11B1	7.09e-05	189	101	5	ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	FNBP1L ITGA9 NRXN3 CNTN3 GAREM1	7.27e-05	190	101	5	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABCA1 MYO7A SAMSN1 RYR1 FRMD4A	7.27e-05	190	101	5	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	Control-Myeloid-transitional_Macro\|Control / Disease group,lineage and cell class （2021.01.30）	HIF1A ABCA1 MYO7A HTRA4 ATP1A4	7.45e-05	191	101	5	3ed0b1ff628a165e3c92c2e493206015f57dccfe
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA1 SAMSN1 RYR1 MS4A14 FYB1	7.45e-05	191	101	5	51f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	LRRK2 SAMSN1 GLIPR2 MS4A14 FYB1	7.45e-05	191	101	5	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HIF1A ABCA1 SBNO2 FRMD4A SYNJ2	7.45e-05	191	101	5	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA1 SAMSN1 RYR1 MS4A14 FYB1	7.45e-05	191	101	5	8fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 LAMA2 HTRA4 GLIPR2 HSD11B1	7.45e-05	191	101	5	1efb47743b6834b64cb0f61721ddbe875b1a66ca
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 LAMA2 HTRA4 GLIPR2 HSD11B1	7.64e-05	192	101	5	5e6f8206ee0b10cdba79a7c4a05452cb025a5512
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PCLO LRRK2 DNAH14 KNDC1 GAREM1	7.64e-05	192	101	5	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	PCLO LRRK2 DNAH14 NRXN3 KNDC1	7.64e-05	192	101	5	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 LAMA2 HTRA4 GLIPR2 HSD11B1	7.64e-05	192	101	5	136af0186c70c14c5f2b33ed7a148156de5b478c
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SAMSN1 DENND1B AHNAK GLIPR2 FYB1	7.82e-05	193	101	5	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL3A1 LAMA2 CNTN3 MACF1 PKN2	7.82e-05	193	101	5	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	GTDC1 FRMD4A FIG4 GLIPR2 TPRG1	7.82e-05	193	101	5	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	MYO7A SAMSN1 RYR1 FRMD4A FYB1	7.82e-05	193	101	5	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	Immune-interstitial_macrophage_(C1Q_positive)\|World / Lineage, Cell type, age group and donor	MYO7A SAMSN1 RYR1 FRMD4A FYB1	7.82e-05	193	101	5	64d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 LUZP1 TSC22D1 MACF1 PKN2	8.02e-05	194	101	5	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IKZF2 CBX4 MACF1 TPRG1 NLRC3	8.02e-05	194	101	5	24837a27b0041fe8c348225fa8b09b127d743603
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	HIF1A ABCA1 SAMSN1 RYR1 FYB1	8.02e-05	194	101	5	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL3A1 LAMA2 CNTN3 MACF1 PKN2	8.02e-05	194	101	5	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCLO FNBP1L DNAH14 GLDC GAREM1	8.02e-05	194	101	5	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA1 SAMSN1 RYR1 MS4A14 FYB1	8.02e-05	194	101	5	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 LAMA2 ITGA9 TSC22D1 NRXN3	8.21e-05	195	101	5	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	HIF1A ABCA1 SAMSN1 FRMD4A FYB1	8.21e-05	195	101	5	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	PND01-Mesenchymal-Mesenchymal_structural\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 MAPT DRAP1 MACF1 HSD11B1	8.21e-05	195	101	5	6bb6349d6ec8da094fe1c7c590021989337aeb0b
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SAMSN1 RYR1 MS4A14 FYB1 PADI2	8.21e-05	195	101	5	c707885d092aedbbe14f51f7de4a5911c9214289
ToppCell	E17.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL3A1 ITGA9 TSC22D1 NRXN3 RGS6	8.21e-05	195	101	5	1daddd801bd4596fffbdb822fc326d5127c96004
ToppCell	Control-Classical_Monocyte-cMono_2\|Control / Disease condition and Cell class	LRRK2 RAB11FIP1 AHNAK GLIPR2 FYB1	8.21e-05	195	101	5	0fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA1 RYR1 FRMD4A MS4A14 FYB1	8.21e-05	195	101	5	42bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCell	E17.5-Mesenchymal-myocytic_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL3A1 ITGA9 TSC22D1 NRXN3 RGS6	8.21e-05	195	101	5	01a750d660993017af00736215cbcff2de5909c1
ToppCell	Control-Myeloid\|Control / Disease state, Lineage and Cell class	HIF1A ABCA1 SAMSN1 FRMD4A GLIPR2	8.21e-05	195	101	5	46ce2e403ca5d757e5ba17349b6c7ce5cde1f195
Drug	bromfenacoum	ABCA2 SPTAN1 POLR2A LRRC59 YARS1 LUZP1 IVD TSC22D1 IARS2 GLDC AHNAK CFDP1 MACF1 SETD3 PADI2	1.58e-07	644	101	15	ctd:C013418
Drug	Sanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A	PCLO YTHDC2 SOCS6 TRRAP GLYR1 AHNAK MACF1 SLC23A2	2.20e-06	191	101	8	4168_DN
Drug	Flucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; HL60; HT_HG-U133A	ABCA2 PCLO YTHDC2 PDZD7 CCDC57 SBNO2 FYB1 PADI2	2.87e-06	198	101	8	3128_UP
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; HL60; HT_HG-U133A	MPP2 ABCA2 MAPT PDZD7 SBNO2 KMT2D RBM19 AHNAK	2.98e-06	199	101	8	2354_UP
Drug	dimethyl maleate	SPTAN1 PARP1	1.95e-05	2	101	2	ctd:C004780
Drug	Calycanthine [595-05-1]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ABCA2 MYO7A MAPT GTDC1 RYR1 FRMD4A SYNJ2	2.48e-05	193	101	7	2764_UP
Drug	Spironolactone [52-01-7]; Up 200; 9.6uM; PC3; HT_HG-U133A	ABCA2 MYL2 POLR2A CCDC57 FRMD4A AHNAK OTUD4	2.73e-05	196	101	7	5781_UP
Drug	Nifedipine [21829-25-4]; Up 200; 11.6uM; HL60; HT_HG-U133A	ABCA1 ABCA2 CCDC57 SBNO2 IVD RBM19 GAREM1	2.73e-05	196	101	7	1856_UP
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; MCF7; HT_HG-U133A	MPP2 MAPT PCLO SBNO2 RBM19 KCNK5 RASSF8	2.92e-05	198	101	7	3632_DN
Drug	Y-27632; Down 200; 3uM; MCF7; HT_HG-U133A_EA	MPP2 ABCA2 MAPT LUZP1 SBNO2 GLYR1 GAREM1	2.92e-05	198	101	7	948_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	ABCA1 MAPT SOCS6 FRMD4A SYNJ2 GLYR1 QSER1	3.01e-05	199	101	7	3759_DN
Disease	Malignant neoplasm of breast	HIF1A SPTAN1 LAMA2 DTX3L ITGA9 TERT PHGDH PARP1 KMT2D OTOF SYNJ2 FGF4 MACF1 UTP20 HSD11B1 DNMT1	4.89e-07	1074	98	16	C0006142
Disease	Usher syndrome type 2	MYO7A PDZD7	3.27e-05	3	98	2	C0339534
Disease	red blood cell density measurement	TPD52L3 MAPT BCAS3 FNBP1L TERT PHGDH FRMD4A KCNK5 OTUD4 PKN2 FYB1 HERC4	3.55e-05	880	98	12	EFO_0007978
Disease	migraine disorder, diastolic blood pressure	ARID4A CFDP1 KCNK5	7.75e-05	25	98	3	EFO_0006336, MONDO_0005277
Disease	Usher Syndrome, Type II	MYO7A PDZD7	1.08e-04	5	98	2	C1568249
Disease	Autosomal Dominant Parkinsonism	MAPT LRRK2 PARP1	1.10e-04	28	98	3	C0752098
Disease	Autosomal Dominant Juvenile Parkinson Disease	MAPT LRRK2 PARP1	1.10e-04	28	98	3	C0752097
Disease	Parkinsonism, Experimental	MAPT LRRK2 PARP1	1.10e-04	28	98	3	C0752101
Disease	Autosomal Recessive Parkinsonism	MAPT LRRK2 PARP1	1.10e-04	28	98	3	C0752100
Disease	Familial Juvenile Parkinsonism	MAPT LRRK2 PARP1	1.10e-04	28	98	3	C0752104
Disease	Ramsay Hunt Paralysis Syndrome	MAPT LRRK2 PARP1	1.10e-04	28	98	3	C0242423
Disease	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	MAPT LRRK2 PARP1	1.10e-04	28	98	3	C1868675
Disease	Parkinsonism, Juvenile	MAPT LRRK2 PARP1	1.35e-04	30	98	3	C0752105
Disease	Parkinsonian Disorders	MAPT LRRK2 PARP1	1.35e-04	30	98	3	C0242422
Disease	snoring measurement	MAPT POLR2A MACF1 SETD3	1.80e-04	84	98	4	EFO_0008341
Disease	melanoma	MYO7A DRAP1 TRRAP TERT PHGDH PARP1	1.83e-04	248	98	6	C0025202
Disease	Familial Dementia	MAPT DNMT1	3.02e-04	8	98	2	C0751071
Disease	Senile Paranoid Dementia	MAPT DNMT1	3.02e-04	8	98	2	C0338630
Disease	Mammary Carcinoma, Human	HIF1A TERT PHGDH PARP1 KMT2D SYNJ2 FGF4 DNMT1	3.69e-04	525	98	8	C4704874
Disease	Mammary Neoplasms, Human	HIF1A TERT PHGDH PARP1 KMT2D SYNJ2 FGF4 DNMT1	3.69e-04	525	98	8	C1257931
Disease	Mammary Neoplasms	HIF1A TERT PHGDH PARP1 KMT2D SYNJ2 FGF4 DNMT1	3.79e-04	527	98	8	C1458155
Disease	underweight body mass index status	NRXN3 RGS6	3.87e-04	9	98	2	EFO_0005936
Disease	bladder neck obstruction (biomarker_via_orthology)	COL3A1 HIF1A	3.87e-04	9	98	2	DOID:13948 (biomarker_via_orthology)
Disease	Breast Carcinoma	HIF1A TERT PHGDH PARP1 KMT2D SYNJ2 FGF4 DNMT1	4.34e-04	538	98	8	C0678222
Disease	middle cerebral artery infarction (implicated_via_orthology)	HIF1A MAPT PARP1	4.56e-04	45	98	3	DOID:3525 (implicated_via_orthology)
Disease	peripheral arterial disease, traffic air pollution measurement	ABCA1 CCDC57 FRMD4A CNTN3 MACF1	4.83e-04	194	98	5	EFO_0004265, EFO_0007908
Disease	amino acid metabolic disorder (is_implicated_in)	PHGDH IVD	5.89e-04	11	98	2	DOID:9252 (is_implicated_in)
Disease	Congenital muscular dystrophy	LAMA2 RYR1	7.05e-04	12	98	2	cv:C0699743
Disease	severe acute respiratory syndrome, COVID-19	IKZF2 MYO7A MAPT RGS6 SYNJ2 GLDC SLC23A2	7.39e-04	447	98	7	EFO_0000694, MONDO_0100096
Disease	urate measurement	MPP2 ABCA1 MYL2 BCAS3 FNBP1L DRAP1 PHGDH KCNK5 FGF4 HERC4	7.91e-04	895	98	10	EFO_0004531
Disease	hip bone mineral density	NRXN3 RGS6 TTC21B FGF14	8.40e-04	126	98	4	EFO_0007702
Disease	uric acid measurement	ABCA1 MYL2 BCAS3 FNBP1L DRAP1 KCNK5 HERC4 GAREM1	9.82e-04	610	98	8	EFO_0004761
Disease	lung non-small cell carcinoma (is_implicated_in)	HIF1A TERT KMT2D DNMT1	1.21e-03	139	98	4	DOID:3908 (is_implicated_in)
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	TDRD15 MYL2 CFDP1	1.22e-03	63	98	3	EFO_0001645, EFO_0004792
Disease	phospholipid measurement	MPP2 TDRD15 ABCA1 ITGA9	1.24e-03	140	98	4	EFO_0004639
Disease	sporadic amyotrophic lateral sclerosis	LAMA2 ITGA9 RGS6 RBM19	1.24e-03	140	98	4	EFO_0001357
Disease	forced expiratory volume	BCAS3 CKAP5 IVD NRXN3 FIG4 AHNAK CFDP1 OTUD4 GAREM1	1.26e-03	789	98	9	EFO_0004314
Disease	Schizoaffective disorder-bipolar type	PCLO NRXN3	1.27e-03	16	98	2	EFO_0009965
Disease	vitamin C measurement	BCAS3 SLC23A2	1.27e-03	16	98	2	EFO_0600003
Disease	stomach cancer (is_marker_for)	TERT PARP1 KMT2D GLDC	1.31e-03	142	98	4	DOID:10534 (is_marker_for)
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	MPP2 IKZF2 ARID4A MAPT LAMA2 NRXN3 DENND1B RBM19 CNTN3	1.40e-03	801	98	9	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	Dementia	MAPT DNMT1	1.44e-03	17	98	2	C0497327
Disease	interstitial lung disease	MAPT TERT IVD	1.46e-03	67	98	3	EFO_0004244
Disease	Dermatitis, Allergic Contact	CNTN3 HSD11B1 FYB1	1.46e-03	67	98	3	C0162820
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	COL3A1 HIF1A HSD11B1 DNMT1	1.49e-03	147	98	4	DOID:9352 (biomarker_via_orthology)
Disease	intraocular pressure measurement	ABCA1 BCAS3 PCLO CKAP5 SYNJ2 KCNK5 PKN2	1.56e-03	509	98	7	EFO_0004695
Disease	rheumatoid arthritis (is_marker_for)	HIF1A LRRK2 DNMT1	1.59e-03	69	98	3	DOID:7148 (is_marker_for)
Disease	migraine disorder, systolic blood pressure	CFDP1 KCNK5	1.61e-03	18	98	2	EFO_0006335, MONDO_0005277
Disease	Congenital Fiber Type Disproportion	MYL2 RYR1	1.61e-03	18	98	2	C0546264
Disease	metabolite measurement, diet measurement	BCAS3 GLDC AHNAK	1.72e-03	71	98	3	EFO_0004725, EFO_0008111
Disease	tissue plasminogen activator measurement, coronary artery disease	TDRD15 MYL2 CFDP1	1.72e-03	71	98	3	EFO_0001645, EFO_0004791
Disease	familial hyperlipidemia (biomarker_via_orthology)	ABCA1 HSD11B1	1.80e-03	19	98	2	DOID:1168 (biomarker_via_orthology)
Disease	Usual Interstitial Pneumonia	HIF1A TERT	1.80e-03	19	98	2	C4721509
Disease	Hamman-Rich Disease	HIF1A TERT	1.80e-03	19	98	2	C4721508
Disease	kidney failure (biomarker_via_orthology)	HIF1A PARP1	1.80e-03	19	98	2	DOID:1074 (biomarker_via_orthology)
Disease	Non-Small Cell Lung Carcinoma	HIF1A LRRC59 TERT PHGDH	1.85e-03	156	98	4	C0007131
Disease	hematocrit	TDRD15 TPD52L3 MAPT BCAS3 TERT PHGDH FRMD4A KCNK5 PKN2 PADI2	1.96e-03	1011	98	10	EFO_0004348
Disease	Familial Idiopathic Pulmonary Fibrosis	HIF1A TERT	2.00e-03	20	98	2	C4721952
Disease	alkaline phosphatase measurement	TDRD15 MAPT FNBP1L ITIH4 SBNO2 RGS6 SYNJ2 AHNAK MACF1 DNMT1	2.02e-03	1015	98	10	EFO_0004533
Disease	coronary artery disease	TDRD15 ABCA1 MYL2 ARID4A BCAS3 ITIH4 PARP1 DENND1B CFDP1 KCNK5 PKN2	2.04e-03	1194	98	11	EFO_0001645
Disease	Parkinson's disease (is_implicated_in)	MAPT LRRK2 PARP1	2.10e-03	76	98	3	DOID:14330 (is_implicated_in)
Disease	palmitoylcarnitine measurement	SAMSN1 ATP1A4	2.20e-03	21	98	2	EFO_0021044
Disease	Idiopathic Pulmonary Fibrosis	HIF1A TERT	2.20e-03	21	98	2	C1800706
Disease	Parkinson disease	MAPT LRRK2	2.42e-03	22	98	2	cv:C0030567
Disease	brain measurement, neuroimaging measurement	MPP2 ABCF3 LUZP1 DENND1B MACF1 FGF14 SETD3	2.42e-03	550	98	7	EFO_0004346, EFO_0004464
Disease	pulmonary hypertension (biomarker_via_orthology)	HIF1A TERT RYR1	2.43e-03	80	98	3	DOID:6432 (biomarker_via_orthology)
Disease	Ovarian Serous Adenocarcinoma	LRRK2 TRRAP	2.64e-03	23	98	2	C1335177
Disease	mortality	IKZF2 ITGA9 NRXN3 OTUD7A	2.69e-03	173	98	4	EFO_0004352
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	YARS1 FIG4	2.87e-03	24	98	2	DOID:10595 (implicated_via_orthology)
Disease	lung squamous cell carcinoma (is_implicated_in)	TERT KMT2D	2.87e-03	24	98	2	DOID:3907 (is_implicated_in)
Disease	neuroimaging measurement	MPP2 MAPT LAMA2 GTDC1 LUZP1 DENND1B MACF1 TPRG1 QSER1 SETD3	2.93e-03	1069	98	10	EFO_0004346
Disease	migraine disorder, Headache	MAPT CFDP1 KCNK5	2.98e-03	86	98	3	HP_0002315, MONDO_0005277
Disease	daytime rest measurement	MAPT LRRK2 FRMD4A NRXN3 FGF4	3.08e-03	295	98	5	EFO_0007828
Disease	systemic mastocytosis	ABCA1 ABCA2	3.12e-03	25	98	2	MONDO_0016586
Disease	medial orbital frontal cortex volume measurement	BCAS3 NRXN3	3.12e-03	25	98	2	EFO_0010315
Disease	Kidney Diseases	TERT PARP1 TTC21B	3.18e-03	88	98	3	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
QNPKDGTLASKMGKA	TTC21B	751	Q7Z4L5
SDGNSGLMAKKQKRT	ARID4A	1076	P29374
KDMVKFGGSGRSKQA	DNMT1	671	P26358
LKSKTSQLSGGMQRK	ABCA1	1026	O95477
GVNGAGKSSTFKMLT	ABCA1	1946	O95477
ENGAGKSTMLKLLLG	ABCF3	526	Q9NUQ8
TGGLEGKMKGTKVKT	AHNAK	476	Q09666
MLQGKKVIVTGASKG	HSD11B1	31	P28845
SAAKTLKSGLTMVGK	BCAS3	271	Q9H6U6
KGKSAGLVKATGRNM	ITIH4	111	Q14624
NGGMGTKSKDKKLSG	DRAP1	121	Q14919
KRKSLTFTGGAKGLM	RASSF8	126	Q8NHQ8
ISKKKNKAGVLLSMG	RBM19	761	Q9Y4C8
SGKKMKKPSTSGQNF	OTUD4	341	Q01804
SGGTAISKIKMNGKA	QSER1	1626	Q2KHR3
KGKSLAGKRLTGLMQ	RGS6	456	P49758
MIEKLGGKLTGTANK	PARP1	411	P09874
MAPKKAKKRAGGANS	MYL2	1	P10916
STNKKMKSDGLGASG	KIAA1107	61	Q9UPP5
KALMDLLAGKGSQGS	NLRC3	26	Q7RTR2
GAGESGKSTIVKQMK	GNAT1	36	P11488
MTKAGSKGGNLRDKL	LRRC59	1	Q96AG4
GMAKKVTKAGGSAAL	H1-10	16	Q92522
MEGAGGANDKKKISS	HIF1A	1	Q16665
GSKKIDPNMKAGATS	DYNC1LI1	426	Q9Y6G9
SNGGKFMKKTLIGEA	PCLO	5101	Q9Y6V0
GMFIALSKNGKTKKG	FGF4	176	P08620
KQIGKKAMKTSGGGE	KCNK5	306	O95279
SKMKQSLGISISGGI	PDZD7	866	Q9H5P4
IGKLNSISKLGKGKM	GAREM1	181	Q9H706
GMKSLKLVIQSTGGG	HERC4	1001	Q5GLZ8
ASAIMNGGKPVNKSK	FGF14	231	Q92915
PKLTGVKGKFMSASQ	FYB1	171	O15117
VKKNMGEGKKRVSSG	GLYR1	136	Q49A26
LDMGSGTIKVKATQK	NRXN3	521	Q9Y4C0
KTKKSDLGMQSATVG	LRRK2	1356	Q5S007
NAMLFVGGLTGKLKK	LAMA2	2276	P24043
GTLCGSLSGKKKKRM	MPP2	331	Q14168
SKTLGIKLKKNMGGL	OTUD7A	521	Q8TE49
KGLGGMSSKRITINK	PADI2	516	Q9Y2J8
GFSTSKKLDKLGMRG	IVD	236	P26440
IEKLTGNMGKRKSST	IKZF2	266	Q9UKS7
KQLAGGMVSLKSGRK	MACF1	1736	Q9UPN3
STGRKQGKAGLQMKS	PYGO2	26	Q9BRQ0
SGTLIKIFQASGKKM	ITGA9	286	Q13797
KTMVGGQLKNLTGSL	CPLX3	6	Q8WVH0
KLANMGSKGKIISGS	FRMD4A	351	Q9P2Q2
GLSSKAKSAQGKKMP	CKAP5	1131	Q14008
SSGMSSLLGKIGAKK	CFDP1	221	Q9UEE9
STKQRGGKELGMKDS	HTRA4	296	P83105
SGKMDAKTTVGKAKG	FNBP1L	306	Q5T0N5
KAKQYVLKGGGMSSL	DTX3L	501	Q8TDB6
VLKGGGMSSLAGKKL	DTX3L	506	Q8TDB6
NTKKMGVGKASASDG	GLIPR2	111	Q9H4G4
TKMGQKGSSGLFRAV	FIG4	76	Q92562
ASMSKGRPKLGSSKG	CCDC188	321	H7C350
VTGNGIGGKMKIVKN	CBX4	241	O00257
LGVNGAGKTSTFKML	ABCA2	2086	Q9BZC7
PGMKTAAQAKAKTTG	CCDC57	876	Q2TAC2
TKKIENAMKTGGSVL	DNAH14	2556	Q0VDD8
KKIMGGSGTETTLEK	LUZP1	766	Q86V48
KKSKLLGQGVTGMNV	MS4A14	101	Q96JA4
GSDVKTMLSKLKGQL	KNDC1	1161	Q76NI1
QASGNVKKALKLMGS	COL3A1	1381	P02461
DNGKQGSLDSTMKGK	EME1	326	Q96AY2
TTHLKKMLGLKGNGG	GTDC1	181	Q4AE62
VKKGGALFNTAMTKA	DENND1B	426	Q6P3S1
KGETGAMVSSTLKLG	RYR1	3786	P21817
GGKEESSSKMKVAGN	CNTN3	846	Q9P232
MKGKENLTGKGITQI	C18orf63	566	Q68DL7
NTEGLKGSMKGKEKA	OTOF	1361	Q9HC10
MKVPSAGGRKKAFST	OR1M1	226	Q8NGA1
LYGRMKNKTGSKTQG	UTP20	1016	O75691
LLSLMTGKKDVAKGS	RAB11FIP1	436	Q6WKZ4
MTKLGSISCKSLKGG	YARS1	511	P54577
GKKGAATKMAAVTAP	VCX3A	51	Q9NNX9
GKKGAATKMAAVTAP	VCX3B	51	Q9H321
GKKGAATKMAAVTAP	VCY	51	O14598
IDTVKTGMGGKAGNK	SYNJ2	651	O15056
SKNKMKTSLNDGLKG	TDRD15	1221	B5MCY1
QSKTSNNGGGLGKKM	SAMSN1	56	Q9NSI8
MGKKSRVKTQKSGTG	SETD3	1	Q86TU7
KAKNAGSTKMGKAVL	SBNO2	391	Q9Y2G9
HVMNISTGKKVKGGS	WDR13	286	Q9H1Z4
FTLGEKGEKMSKSLG	IARS2	656	Q9NSE4
GGTQMKKKSGFQITS	TSC22D1	101	Q15714
AKNVMKLLGSGKVTD	PKN2	236	Q16513
LKKADIGIAMGISGS	ATP1A4	731	Q13733
GKKGAATKMAAVTAP	VCX2	51	Q9H322
KGVGKGNKSLDGMES	SLC23A2	586	Q9UGH3
MKGAKSGKGAVTSEA	MRPL54	41	Q6P161
NISSKMKGLNGKVSD	SPTAN1	1946	Q13813
IMGILCKKSLGTSAG	POLR2A	636	P24928
KGHTSQMELKTGKGA	SOGA1	786	O94964
LGGNGLKRTKSVSSM	SOGA1	916	O94964
AHKNSTGSGRGKKLM	TPRG1	226	Q6ZUI0
SSGAKEMKLKGADGK	MAPT	451	P10636
GKKGAATKMAAVTAP	VCX	51	Q9H320
LSQSLGLVSKSKGKG	YTHDC2	81	Q9H6S0
KKFMGTELNGKTLGI	PHGDH	136	O43175
MGTLICRKLGGVKKS	TPD52L3	101	Q96J77
GKFGGSNRKMLKESQ	TRRAP	896	Q9Y4A5
EKGGKNRSKSESLMG	SOCS6	61	O14544
ILKAKNAGMSLGAKG	TERT	1046	O14746
MGGKGLKQATETAIL	GLDC	821	P23378
ALKGIKKVMAQGSIG	KMT2D	3431	O14686
GMSEDQKKKLGLGQA	MYO7A	261	Q13402