Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	channel activity	CACNA1C CACNA1F GJA4 SLC9C1 PIEZO2 PIEZO1 MFSD8 GJA10 ANO10 PKDREJ	2.04e-05	525	73	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1C CACNA1F GJA4 SLC9C1 PIEZO2 PIEZO1 MFSD8 GJA10 ANO10 PKDREJ	2.07e-05	526	73	10	GO:0022803
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9C1 SLC9A8 SLC38A5	2.54e-05	16	73	3	GO:0015385
GeneOntologyMolecularFunction	transporter activity	CACNA1C CACNA1F GJA4 SLC9C1 SLC9A8 PIEZO2 SLC12A1 PIEZO1 SLC38A5 MFSD8 PLSCR2 GJA10 ANO10 SLC35E2B PKDREJ	5.42e-05	1289	73	15	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1C CACNA1F GJA4 SLC9C1 SLC9A8 PIEZO2 SLC12A1 PIEZO1 SLC38A5 MFSD8 GJA10 ANO10 SLC35E2B PKDREJ	8.16e-05	1180	73	14	GO:0022857
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC9C1 SLC9A8 SLC38A5	1.29e-04	27	73	3	GO:0051139
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1C CACNA1F SLC9C1 SLC9A8 PIEZO2 SLC12A1 PIEZO1 SLC38A5 MFSD8 ANO10 PKDREJ	1.36e-04	793	73	11	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1C CACNA1F SLC9C1 SLC9A8 PIEZO2 SLC12A1 PIEZO1 SLC38A5 ANO10 PKDREJ	1.45e-04	664	73	10	GO:0008324
GeneOntologyMolecularFunction	pheromone receptor activity	VN1R2 VN1R17P	1.96e-04	6	73	2	GO:0016503
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1C CACNA1F SLC9C1 PIEZO2 PIEZO1 MFSD8 ANO10 PKDREJ	2.67e-04	459	73	8	GO:0005216
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC9C1 SLC9A8 SLC38A5	5.21e-04	43	73	3	GO:0140828
GeneOntologyMolecularFunction	olfactory receptor activity	OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1	9.94e-04	431	73	7	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	VN1R2 EPOR OR4S1 LMBR1L OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 VN1R17P OR6Y1 LPAR2 IL5RA	1.14e-03	1353	73	13	GO:0004888
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1F	1.17e-03	14	73	2	GO:0008331
GeneOntologyMolecularFunction	potassium:proton antiporter activity	SLC9C1 SLC9A8	1.17e-03	14	73	2	GO:0015386
GeneOntologyMolecularFunction	G protein-coupled receptor activity	VN1R2 OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 VN1R17P OR6Y1 LPAR2	1.36e-03	884	73	10	GO:0004930
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1C CACNA1F SLC9C1 SLC9A8 SLC12A1 SLC38A5 PKDREJ	1.54e-03	465	73	7	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1C CACNA1F PIEZO2 PIEZO1 ANO10 PKDREJ	1.59e-03	343	73	6	GO:0005261
GeneOntologyMolecularFunction	antiporter activity	SLC9C1 SLC9A8 SLC38A5 SLC35E2B	1.64e-03	138	73	4	GO:0015297
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1C CACNA1F SLC9C1 SLC9A8 SLC12A1 SLC38A5 MFSD8 ANO10 PKDREJ	1.73e-03	758	73	9	GO:0015318
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	PIEZO2 PIEZO1	1.94e-03	18	73	2	GO:0008381
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC9C1 SLC9A8	2.17e-03	19	73	2	GO:0022821
GeneOntologyMolecularFunction	phospholipid scramblase activity	PLSCR2 ANO10	3.17e-03	23	73	2	GO:0017128
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC9C1 SLC9A8 SLC12A1 SLC38A5	3.57e-03	171	73	4	GO:0015081
GeneOntologyMolecularFunction	gap junction channel activity	GJA4 GJA10	3.75e-03	25	73	2	GO:0005243
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC9C1 SLC9A8 SLC12A1 SLC38A5 SLC35E2B	4.57e-03	296	73	5	GO:0015291
GeneOntologyBiologicalProcess	detection of stimulus	CACNA1F OR4S1 PIEZO2 OR6Q1 PIEZO1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1 GJA10 PKDREJ	5.95e-06	722	71	12	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	VN1R2 CACNA1F OR4S1 PIEZO2 IAPP OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 VN1R17P OR6Y1 GJA10 CRB2	1.44e-05	1072	71	14	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	CACNA1F OR4S1 PIEZO2 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1 GJA10	2.91e-05	582	71	10	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	VN1R2 OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 VN1R17P OR6Y1	1.05e-04	547	71	9	GO:0007606
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1C CACNA1F SLC9C1 SLC12A1 SLC38A5 ARHGEF11	1.41e-04	230	71	6	GO:0098739
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	CA12 CACNA1C CACNA1F LETMD1 SLC9C1 SLC9A8 TMEM203 SLC12A1 PKHD1 JPH2	1.43e-04	705	71	10	GO:0055080
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	CA12 CACNA1C CACNA1F LETMD1 SLC9C1 SLC9A8 TMEM203 SLC12A1 PKHD1 JPH2	1.65e-04	717	71	10	GO:0050801
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	CA12 ACSL4 EPOR SLC9C1 SLC9A8 TMEM203 MARF1 CASP2 HFM1 GJA10 DCST2 TEX14 HERC2	1.93e-04	1194	71	13	GO:0048609
GeneOntologyBiologicalProcess	detection of external stimulus	CACNA1F PIEZO2 PIEZO1 GJA10 PKDREJ	3.26e-04	173	71	5	GO:0009581
GeneOntologyBiologicalProcess	detection of abiotic stimulus	CACNA1F PIEZO2 PIEZO1 GJA10 PKDREJ	3.44e-04	175	71	5	GO:0009582
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1C CACNA1F SLC9C1 SLC9A8 PIEZO2 SLC12A1 PIEZO1 JPH2 SLC38A5 ANO10 PKDREJ	3.53e-04	942	71	11	GO:0098655
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1C CACNA1F SLC9C1 SLC9A8 PIEZO2 SLC12A1 PIEZO1 JPH2 SLC38A5 MFSD8 ANO10 PKDREJ	3.90e-04	1115	71	12	GO:0034220
MousePheno	abnormal retina outer plexiform layer morphology	EPOR CACNA1F GJA10 CRB2	2.12e-05	46	50	4	MP:0003732
Domain	Sec63	HFM1 ASCC3 SNRNP200	2.29e-07	4	73	3	PF02889
Domain	Sec63	HFM1 ASCC3 SNRNP200	2.29e-07	4	73	3	SM00973
Domain	Sec63-dom	HFM1 ASCC3 SNRNP200	2.29e-07	4	73	3	IPR004179
Domain	PIEZO	PIEZO2 PIEZO1	1.51e-05	2	73	2	PF15917
Domain	Piezo_RRas-bd_dom	PIEZO2 PIEZO1	1.51e-05	2	73	2	IPR031334
Domain	Piezo	PIEZO2 PIEZO1	1.51e-05	2	73	2	IPR027272
Domain	Piezo_RRas_bdg	PIEZO2 PIEZO1	1.51e-05	2	73	2	PF12166
Domain	Piezo_dom	PIEZO2 PIEZO1	1.51e-05	2	73	2	IPR031805
Domain	CAC1F_C	CACNA1C CACNA1F	4.51e-05	3	73	2	IPR031688
Domain	CAC1F_C	CACNA1C CACNA1F	4.51e-05	3	73	2	PF16885
Domain	VDCC_L_a1su	CACNA1C CACNA1F	9.00e-05	4	73	2	IPR005446
Domain	VDCC_a1su_IQ	CACNA1C CACNA1F	3.12e-04	7	73	2	IPR014873
Domain	GPHH	CACNA1C CACNA1F	3.12e-04	7	73	2	PF16905
Domain	GPHH_dom	CACNA1C CACNA1F	3.12e-04	7	73	2	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1F	3.12e-04	7	73	2	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1F	3.12e-04	7	73	2	PF08763
Domain	VDCCAlpha1	CACNA1C CACNA1F	6.64e-04	10	73	2	IPR002077
Domain	Cation/H_exchanger_CPA1	SLC9C1 SLC9A8	8.10e-04	11	73	2	IPR018422
Domain	Olfact_rcpt	OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1	8.55e-04	393	73	7	IPR000725
Domain	GPCR_Rhodpsn_7TM	VN1R2 OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1 LPAR2	1.17e-03	670	73	9	IPR017452
Domain	Na_H_Exchanger	SLC9C1 SLC9A8	1.33e-03	14	73	2	PF00999
Domain	Cation/H_exchanger	SLC9C1 SLC9A8	1.33e-03	14	73	2	IPR006153
Domain	G_PROTEIN_RECEP_F1_1	VN1R2 OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1 LPAR2	1.36e-03	685	73	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	VN1R2 OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1 LPAR2	1.44e-03	691	73	9	PS50262
Domain	GPCR_Rhodpsn	VN1R2 OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1 LPAR2	1.46e-03	692	73	9	IPR000276
Domain	CONNEXINS_1	GJA4 GJA10	2.47e-03	19	73	2	PS00407
Domain	CONNEXINS_2	GJA4 GJA10	2.74e-03	20	73	2	PS00408
Domain	Connexin	GJA4 GJA10	2.74e-03	20	73	2	IPR000500
Domain	Connexin_CCC	GJA4 GJA10	2.74e-03	20	73	2	IPR019570
Domain	Connexin_N	GJA4 GJA10	2.74e-03	20	73	2	IPR013092
Domain	Connexin	GJA4 GJA10	2.74e-03	20	73	2	PF00029
Domain	Connexin_CCC	GJA4 GJA10	2.74e-03	20	73	2	SM01089
Domain	Connexin_CS	GJA4 GJA10	2.74e-03	20	73	2	IPR017990
Domain	CNX	GJA4 GJA10	2.74e-03	20	73	2	SM00037
Domain	DEAD/DEAH_box_helicase_dom	HFM1 ASCC3 SNRNP200	2.93e-03	73	73	3	IPR011545
Domain	DEAD	HFM1 ASCC3 SNRNP200	2.93e-03	73	73	3	PF00270
Domain	7tm_1	OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1 LPAR2	4.83e-03	677	73	8	PF00001
Domain	Ig_E-set	PKHD1 ASCC3 SNRNP200	7.87e-03	104	73	3	IPR014756
Domain	Helicase_C	HFM1 ASCC3 SNRNP200	8.50e-03	107	73	3	PF00271
Domain	HELICc	HFM1 ASCC3 SNRNP200	8.50e-03	107	73	3	SM00490
Domain	Helicase_C	HFM1 ASCC3 SNRNP200	8.72e-03	108	73	3	IPR001650
Domain	HELICASE_CTER	HFM1 ASCC3 SNRNP200	8.94e-03	109	73	3	PS51194
Pubmed	[Feeling the pressure? Identification of two proteins activated by mechanical forces].	PIEZO2 PIEZO1	4.59e-06	2	75	2	21299953
Pubmed	Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.	PIEZO2 PIEZO1	4.59e-06	2	75	2	38395992
Pubmed	Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.	PIEZO2 PIEZO1	4.59e-06	2	75	2	37820892
Pubmed	Mechanisms of mechanotransduction and physiological roles of PIEZO channels.	PIEZO2 PIEZO1	4.59e-06	2	75	2	39251883
Pubmed	Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.	PIEZO2 PIEZO1	4.59e-06	2	75	2	37975162
Pubmed	Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.	PIEZO2 PIEZO1	4.59e-06	2	75	2	28636944
Pubmed	Nucleotide excision repair factor XPC enhances DNA damage-induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2.	CASP2 XPC	4.59e-06	2	75	2	22174370
Pubmed	Piezo channels: from structure to function.	PIEZO2 PIEZO1	4.59e-06	2	75	2	25037583
Pubmed	Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?	PIEZO2 PIEZO1	4.59e-06	2	75	2	30324494
Pubmed	Mechanosensitive channels: in touch with Piezo.	PIEZO2 PIEZO1	4.59e-06	2	75	2	21056836
Pubmed	Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.	PIEZO2 PIEZO1	4.59e-06	2	75	2	30745454
Pubmed	The role of PIEZO ion channels in the musculoskeletal system.	PIEZO2 PIEZO1	4.59e-06	2	75	2	36717101
Pubmed	Astrocytes in the optic nerve head express putative mechanosensitive channels.	PIEZO2 PIEZO1	4.59e-06	2	75	2	26236150
Pubmed	Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.	PIEZO2 PIEZO1	4.59e-06	2	75	2	27743844
Pubmed	Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.	PIEZO2 PIEZO1	4.59e-06	2	75	2	38928429
Pubmed	A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.	PIEZO2 PIEZO1	4.59e-06	2	75	2	30628892
Pubmed	Piezo1 ion channel pore properties are dictated by C-terminal region.	PIEZO2 PIEZO1	4.59e-06	2	75	2	26008989
Pubmed	Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.	PIEZO2 PIEZO1	4.59e-06	2	75	2	20813920
Pubmed	A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.	PIEZO2 PIEZO1	4.59e-06	2	75	2	32142647
Pubmed	Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.	PIEZO2 PIEZO1	4.59e-06	2	75	2	34464353
Pubmed	A role of PIEZO1 in iron metabolism in mice and humans.	EPOR PIEZO1	1.37e-05	3	75	2	33571427
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO2 PIEZO1	1.37e-05	3	75	2	30726728
Pubmed	Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.	PIEZO2 PIEZO1	1.37e-05	3	75	2	38124148
Pubmed	Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.	PIEZO2 PIEZO1	1.37e-05	3	75	2	29521261
Pubmed	PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.	PIEZO2 PIEZO1	1.37e-05	3	75	2	30361375
Pubmed	Piezo1, a mechanically activated ion channel, is required for vascular development in mice.	PIEZO2 PIEZO1	1.37e-05	3	75	2	24958852
Pubmed	Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse model.	GJA4 GJA10	1.37e-05	3	75	2	18829945
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO2 PIEZO1	1.37e-05	3	75	2	37321223
Pubmed	Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.	PIEZO2 PIEZO1	1.37e-05	3	75	2	35650194
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	PIEZO2 PIEZO1	2.75e-05	4	75	2	27893727
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	PIEZO2 PIEZO1	2.75e-05	4	75	2	36574677
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1F	2.75e-05	4	75	2	20937870
Pubmed	Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.	PIEZO2 PIEZO1	2.75e-05	4	75	2	36563677
Pubmed	Multiple new and isolated families within the mouse superfamily of V1r vomeronasal receptors.	VN1R2 VN1R17P	2.75e-05	4	75	2	11802169
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	PIEZO2 PIEZO1	4.57e-05	5	75	2	34852225
Pubmed	Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.	EPOR PIEZO1	4.57e-05	5	75	2	29576450
Pubmed	Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.	PIEZO2 PIEZO1	4.57e-05	5	75	2	36323321
Pubmed	Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs).	LPAR2 ARHGEF11	6.84e-05	6	75	2	15755723
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DNAJC13 PI4KA HERC2 ASCC3 SNRNP200	7.80e-05	202	75	5	33005030
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	DNAJC13 PKHD1 PDCD11 ASCC3 SNRNP200	7.80e-05	202	75	5	24639526
Pubmed	Genome-wide association analysis identifies 13 new risk loci for schizophrenia.	CACNA1C GLT8D1 PDCD11 LPAR2	9.35e-05	109	75	4	23974872
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1F	9.57e-05	7	75	2	12900400
Pubmed	Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.	PIEZO2 PIEZO1	9.57e-05	7	75	2	38733989
Pubmed	Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors.	VN1R2 VN1R17P	9.57e-05	7	75	2	19387439
Pubmed	Piezo1 and Piezo2 collectively regulate jawbone development.	PIEZO2 PIEZO1	1.27e-04	8	75	2	38619396
Pubmed	TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.	PIEZO2 PIEZO1	1.27e-04	8	75	2	34112781
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	PIEZO2 PIEZO1	1.27e-04	8	75	2	38228630
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	PIEZO2 PIEZO1	1.27e-04	8	75	2	27161260
Pubmed	The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.	SLC12A1 PKHD1	1.27e-04	8	75	2	20215348
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	CACNA1F SLC9A8 MFSD8 GJA10 CRB2	1.52e-04	233	75	5	32290105
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1F	1.64e-04	9	75	2	16382099
Pubmed	Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.	VN1R2 VN1R17P	1.64e-04	9	75	2	36383665
Pubmed	The human olfactory receptor gene family.	OR4S1 OR6Q1 OR1S1 OR1S2 OR52E6 OR2D2 OR6Y1	1.69e-04	541	75	7	14983052
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CA12 NEMP1 CACNA1F PCDHGB3 PI4KA PKHD1 EMP3 SNRNP200	1.87e-04	736	75	8	29676528
Pubmed	Calcium signaling induces partial EMT and renal fibrosis in a Wnt4mCherry knock-in mouse model.	PIEZO2 SLC12A1 PIEZO1	2.09e-04	53	75	3	38653356
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1C CACNA1F	2.49e-04	11	75	2	18809727
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	CACNA1C JPH2	2.99e-04	12	75	2	19095005
Pubmed	Seventy-five genetic loci influencing the human red blood cell.	CACNA1C PIEZO1 OR6Y1	3.32e-04	62	75	3	23222517
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1F	4.73e-04	15	75	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1C CACNA1F	4.73e-04	15	75	2	24453333
Pubmed	The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex.	TCF12 ANKRD36 PLSCR2	5.16e-04	72	75	3	33726789
Pubmed	A vagal reflex evoked by airway closure.	PIEZO2 PIEZO1	5.40e-04	16	75	2	38448588
Pubmed	Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.	CACNA1C JPH2	5.40e-04	16	75	2	32994313
Pubmed	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	POLI CASP2 XPC IL5RA	6.20e-04	179	75	4	19074885
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	COL9A2 DYNC2H1 PI4KA MARF1 POLI	6.70e-04	322	75	5	26514267
Pubmed	An expression atlas of connexin genes in the mouse.	GJA4 GJA10	6.87e-04	18	75	2	15081111
Pubmed	The novel mouse connexin39 gene is expressed in developing striated muscle fibers.	GJA4 GJA10	6.87e-04	18	75	2	15466892
Pubmed	An update on connexin genes and their nomenclature in mouse and man.	GJA4 GJA10	7.66e-04	19	75	2	14681012
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DNAJC13 SALL2 FBXO21	8.96e-04	87	75	3	12465718
Pubmed	Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells.	EPOR IL5RA	9.38e-04	21	75	2	8499630
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	DNAJC13 PI4KA PDCD11	9.57e-04	89	75	3	27034005
Pubmed	Genetic analysis of 22 candidate genes for hypertension in the Japanese population.	GJA4 SLC12A1	1.03e-03	22	75	2	15167446
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ACSL4 PIEZO2 PIEZO1 MARF1 MFSD8 ANO10 TMEM164 HERC2 ASCC3	1.19e-03	1215	75	9	15146197
Pubmed	Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.	PIEZO2 PIEZO1	1.23e-03	24	75	2	32186512
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR6Q1 OR1S2 OR52E6 OR2D2	1.31e-03	219	75	4	12213199
Pubmed	HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis.	SLC12A1 PKHD1	1.33e-03	25	75	2	29158444
Pubmed	Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome.	VN1R2 VN1R17P	1.33e-03	25	75	2	20003482
Pubmed	Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice.	VN1R2 VN1R17P	1.44e-03	26	75	2	21752992
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	NEMP1 SLC9A8 SALL2 SNRNP200	1.45e-03	225	75	4	12168954
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SALL2 HERC2 ARHGEF11	1.50e-03	104	75	3	9205841
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	PDCD11 XPC SNRNP200	1.85e-03	112	75	3	28416769
Pubmed	Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.	DYNC2H1 VN1R17P	1.92e-03	30	75	2	27568566
GeneFamily	X-linked mental retardation\|RNA helicases	HFM1 ASCC3 SNRNP200	3.86e-06	11	53	3	1168
GeneFamily	Gap junction proteins	GJA4 GJA10	1.88e-03	22	53	2	314
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1F	2.62e-03	26	53	2	253
Coexpression	GSE23114_PERITONEAL_CAVITY_B1A_BCELL_VS_SPLEEN_BCELL_UP	GLT8D1 CASP2 HEATR5A SLC35E2B CRB2 SLC66A3	1.34e-05	191	71	6	M8287
CoexpressionAtlas	kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_StemCellamp_top-relative-expression-ranked_500	GJA4 COL9A2 DNAJC13 PIEZO2 PIEZO1 MARF1 JPH2 EMP3	2.05e-06	287	63	8	gudmap_kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_Scamp_500
CoexpressionAtlas	kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_StemCellamp_k-means-cluster#1_top-relative-expression-ranked_100	GJA4 JPH2 EMP3	1.10e-05	15	63	3	gudmap_kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_Scamp_k1_100
CoexpressionAtlas	kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_StemCellamp_top-relative-expression-ranked_200	GJA4 PIEZO2 PIEZO1 JPH2 EMP3	2.44e-05	116	63	5	gudmap_kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_Scamp_200
CoexpressionAtlas	kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_StemCellamp_top-relative-expression-ranked_100	GJA4 PIEZO2 JPH2 EMP3	4.16e-05	65	63	4	gudmap_kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_Scamp_100
CoexpressionAtlas	kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_StemCellamp_top-relative-expression-ranked_1000	GJA4 COL9A2 DNAJC13 PIEZO2 PIEZO1 MARF1 JPH2 EMP3 PKDREJ	7.27e-05	608	63	9	gudmap_kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_Scamp_1000
ToppCell	Control-Neu_0\|World / 5 Neutrophil clusters in COVID-19 patients	PCDHGB3 MARF1 PKHD1 TMEM164 SLC35E2B	1.51e-06	120	72	5	840d0ac995e2fa41996514753e4e03c4aa4a26d0
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1F	3.22e-05	4	69	2	DOID:0060173 (implicated_via_orthology)
Disease	Connective Tissue Diseases	COL9A2 PIEZO2	4.13e-04	13	69	2	C0009782
Disease	urate measurement	CA12 NAA25 DNAJC13 SLC12A1 PKHD1 HFM1 GJA10 TEX14	1.13e-03	895	69	8	EFO_0004531
Disease	osteoarthritis, hip	GLT8D1 PIEZO1 HERC2	1.32e-03	92	69	3	EFO_1000786
Disease	Disorder of eye	CACNA1F COL9A2 MFSD8 SNRNP200	1.55e-03	212	69	4	C0015397
Disease	retinitis pigmentosa (implicated_via_orthology)	SNRNP200 CRB2	1.82e-03	27	69	2	DOID:10584 (implicated_via_orthology)
Disease	lumbar disc degeneration	PIGQ DYNC2H1	1.96e-03	28	69	2	EFO_0004994
Disease	C-C motif chemokine 7 measurement	SALL2 ANKRD36	2.10e-03	29	69	2	EFO_0008054

Protein segments in the cluster

Peptide	Gene	Start	Entry
NVLTIILLPVHLLIT	ACSL4	6	O60488
VLLLCLLHFLVAVIL	B4GALT2	16	O60909
TALLVVLVLLAVALQ	CCL22	6	O00626
HSIAAISLLLNILEI	GJA10	216	Q969M2
ISLLLNILEIFHLGI	GJA10	221	Q969M2
TLDLHVLLLEDLLVL	ARHGEF11	981	O15085
LVLLLEHLLEQKTLS	AOPEP	711	Q8N6M6
DIVILLLQHNIDVLS	ANKRD36	211	A6QL64
GILNIILILAILREH	MFSD8	221	Q8NHS3
LILIVVAVEHALLAL	ANO10	591	Q9NW15
PLLHIALLVLFVIII	CACNA1F	236	O60840
ALSIILHLICLLEKV	FEM1C	441	Q96JP0
LVLKVLDILQHIQTL	FBXO21	446	O94952
NIIALTHTLLLIQLL	OR1S1	166	Q8NH92
ILLNIGLAILFVHLL	JPH2	681	Q9BR39
VLVLLTNLLVIAAIA	LPAR2	41	Q9HBW0
LKEAELSLLLHNVVL	LETMD1	336	Q6P1Q0
QVEVVLHLATLELRL	CRB2	521	Q5IJ48
QHLALAILLELAVQR	HERC2	286	O95714
LHAAAVLLLVILKEQ	CA12	6	O43570
ILIHQQIELLEVLFS	PLSCR2	96	Q9NRY7
IGNLLIIILTTLDVH	OR14L1P	41	Q8NHC6
SLLLLDVLLIILSHI	OR52E6	206	Q96RD3
LFHVLTVLGNLLVII	OR4S1	31	Q8NGB4
IQIPHIALAIIIIAL	NEMP1	296	O14524
KLLILHQAVAVILSL	TCF12	616	Q99081
DEILEVLLQVLHVLL	PI4KA	151	P42356
VNIIILVLAVALFLL	GLT8D1	6	Q68CQ7
LVENLAIILVVGLDH	OR6Q1	41	Q8NGQ2
HLVVALALISVLFLL	PCDHGB3	691	Q9Y5G1
LQVFLIVLSVALNHL	IAPP	6	P10997
NIIALTHTLLLIQLL	OR1S2	166	Q8NGQ3
LVTVLGNLLLISLVH	OR2D2	36	Q9H210
LVQLVRLFLIDEVHI	HFM1	401	A2PYH4
NILILIIINKEAALH	OR56B2P	51	Q8NGI1
LKALILDIIHNIDVV	DYNC2H1	1596	Q8NCM8
HVLLILLGATEILQA	IL5RA	6	Q01344
DLGIELLNVLHRVIL	HEATR5A	1601	Q86XA9
VPLLHIALLVLFVII	CACNA1C	266	Q13936
LLVLLQVVVLALAQI	COL9A2	11	Q14055
IRILVDLLTLAHLHV	DNAJC13	936	O75165
LIELLEAVPHVLQIL	MARF1	1146	Q9Y4F3
VILVLLTVLALLSHR	EPOR	261	P19235
LVVSALHILILILLF	EMP3	6	P54852
LHILILILLFVATLD	EMP3	11	P54852
ILLLIALELVNIHAV	ERMARD	591	Q5T6L9
VGLISLVLNLLELVH	GJA4	216	P35212
ILETFNLIRHLLLVL	DCST2	406	Q5T1A1
QSINLLDVLHIRLLV	POLI	186	Q9UNA4
HLNIPLILEELRVLQ	SALL2	176	Q9Y467
VLAKQLLLSELLEHL	CASP2	46	P42575
EVIVHLLLQISDALR	TEX14	351	Q8IWB6
AITLIGILHVILIEI	SLC9C1	681	Q4G0N8
GLSVLIVAIHILELL	LMBR1L	311	Q6UX01
HVAIALILLVLVNVL	SLC38A5	376	Q8WUX1
LALLLILIVLLRHTD	PKDREJ	1721	Q9NTG1
LVVAVQGLIHLLVDL	PIGQ	476	Q9BRB3
LLLILNHNVVRELDI	RNF215	156	Q9Y6U7
SAVLALLVLINVVLI	SMIM39	36	A0A1B0GW54
LLVLAICIILVHLLI	SLC9A8	66	Q9Y2E8
AQVILLVILLIAIAN	SLC12A1	326	Q13621
IEVLLLAVRHLSLHI	PKHD1	11	P08F94
LLTLLENLLIILAIH	OR6Y1	41	Q8NGX8
LSQIVRLLILDEVHL	ASCC3	601	Q8N3C0
ILNVDLLKLEVHVSL	PDCD11	896	Q14690
VQHLILLHRAVIVVL	TMEM235	86	A6NFC5
LTLALLEILVALRHI	TMEM164	46	Q5U3C3
LLLHIIFHITLVSLE	PIEZO2	71	Q9H5I5
VVLLLLTDGVLFHLQ	SLC35E2B	296	P0CK96
ILIAQDVILLLCIFH	SLC66A3	71	Q8N755
LNHLVLAIPLRVLVV	PLPP6	226	Q8IY26
VHLLALLVFSVLLAL	TMEM203	21	Q969S6
TQLVRLIILDEIHLL	SNRNP200	606	O75643
LIHILLLFTQAILVS	VN1R17P	56	Q8TDU5
NHLQVLLLLVFEAIV	PIEZO1	931	Q92508
EELVHIFLLILRALQ	XPC	296	Q01831
LCISLLQLLLVVVHV	TM4SF19	181	Q96DZ7
LQLLLVVVHVINSLL	TM4SF19	186	Q96DZ7
LILRHLTVADSLVIL	VN1R2	126	Q8NFZ6
LETHLIALKLEELIL	NAA25	911	Q14CX7