Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarbohydrate binding

CALR3 MAN2C1 STBD1 MAN2B1 GANAB P3H1 ACAN VCAN NCAN C4A C4B

6.58e-0531016811GO:0030246
GeneOntologyMolecularFunctionhyaluronic acid binding

ACAN VCAN NCAN IMPG2

9.74e-05291684GO:0005540
GeneOntologyCellularComponentperineuronal net

ACAN VCAN NCAN TNR

8.53e-07101704GO:0072534
GeneOntologyCellularComponentperisynaptic extracellular matrix

ACAN VCAN NCAN TNR

1.33e-06111704GO:0098966
GeneOntologyCellularComponentsynapse-associated extracellular matrix

ACAN VCAN NCAN TNR

2.85e-06131704GO:0099535
GeneOntologyCellularComponentdistal axon

UNC13B SEPTIN4 HAP1 PACSIN1 APBB1 CRTAC1 TSC2 GRIK4 ITGA3 ADORA1 SLC18A1 PAK1 UNC13A KLC1

1.35e-0543517014GO:0150034
GeneOntologyCellularComponentaxon

UNC13B SEPTIN4 HAP1 PACSIN1 APBB1 NFASC CRTAC1 TSC2 GRIK4 IRX3 ITGA3 ADORA1 SLC18A1 SPHK1 PAK1 C4A C4B UNC13A AGTPBP1 KLC1

3.93e-0589117020GO:0030424
GeneOntologyCellularComponentcollagen-containing extracellular matrix

NPHS1 COL15A1 ADAMTS2 INSL5 TGM2 P3H1 LOXL1 ACAN VCAN NCAN CSPG4 LOXL4 TNR IMPG2

1.15e-0453017014GO:0062023
GeneOntologyCellularComponentlysosomal lumen

GALNS MAN2B1 ACAN VCAN NCAN CSPG4

1.50e-04981706GO:0043202
GeneOntologyCellularComponentneuromuscular junction

UNC13B APBB1 ITGA3 FCHSD2 LRP4 UNC13A

3.11e-041121706GO:0031594
GeneOntologyCellularComponentextracellular matrix

NPHS1 COL15A1 ADAMTS2 INSL5 TECTA TGM2 P3H1 LOXL1 ACAN VCAN NCAN CSPG4 LOXL4 TNR IMPG2

3.13e-0465617015GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

NPHS1 COL15A1 ADAMTS2 INSL5 TECTA TGM2 P3H1 LOXL1 ACAN VCAN NCAN CSPG4 LOXL4 TNR IMPG2

3.23e-0465817015GO:0030312
GeneOntologyCellularComponentaxon terminus

UNC13B SEPTIN4 HAP1 PACSIN1 GRIK4 ADORA1 SLC18A1 UNC13A

3.31e-042101708GO:0043679
GeneOntologyCellularComponentneuron to neuron synapse

UNC13B PACSIN1 ANKS1B CRTAC1 TSC2 GRIK4 ADORA1 BNIP3 PAK1 PAK2 LRP4 MACF1 TNR

3.63e-0452317013GO:0098984
GeneOntologyCellularComponentgrowth cone filopodium

APBB1 ITGA3

3.90e-0441702GO:1990812
GeneOntologyCellularComponentvacuolar lumen

GALNS MAN2B1 GDI2 ACAN VCAN NCAN CSPG4

6.47e-041781707GO:0005775
GeneOntologyCellularComponentneuron projection terminus

UNC13B SEPTIN4 HAP1 PACSIN1 GRIK4 ADORA1 SLC18A1 UNC13A

6.59e-042331708GO:0044306
GeneOntologyCellularComponentinterphotoreceptor matrix

VCAN IMPG2

9.65e-0461702GO:0033165
GeneOntologyCellularComponentsomatodendritic compartment

MPL SEPTIN4 HAP1 APBB1 ANKS1B NFASC TSC2 GRIK4 LRIT3 ADORA1 BNIP3 TRIM9 LNPEP BTD ACAN PAK1 LRP4 C4A C4B TACR3 KLC1

1.02e-03122817021GO:0036477
GeneOntologyCellularComponentsite of polarized growth

HAP1 APBB1 CRTAC1 TSC2 FRYL ITGA3 PAK1 KLC1

1.12e-032531708GO:0030427
GeneOntologyCellularComponentterminal bouton

UNC13B GRIK4 ADORA1 SLC18A1 UNC13A

1.13e-03961705GO:0043195
GeneOntologyCellularComponentsecretory vesicle

UNC13B DMXL2 STBD1 GALNS MAN2B1 SEPTIN4 HAP1 PRSS55 NFASC F5 GDI2 LY6G6F PTPRC SYTL4 TRIM9 SLC18A1 LNPEP SPHK1 LOXL1 PAK2 UNC13A

1.22e-03124617021GO:0099503
GeneOntologyCellularComponentexocytic vesicle

UNC13B DMXL2 SEPTIN4 HAP1 SYTL4 TRIM9 SLC18A1 SPHK1 UNC13A

1.26e-033201709GO:0070382
GeneOntologyCellularComponentendoplasmic reticulum lumen

CALR3 FMO1 COL15A1 F5 GANAB CSF1 P3H1 VCAN C4A

1.63e-033321709GO:0005788
GeneOntologyCellularComponentdendrite

SEPTIN4 HAP1 APBB1 ANKS1B NFASC TSC2 GRIK4 LRIT3 ADORA1 BNIP3 TRIM9 PAK1 LRP4 C4A C4B TACR3

1.75e-0385817016GO:0030425
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

1.78e-0381702GO:0106139
GeneOntologyCellularComponentdendritic tree

SEPTIN4 HAP1 APBB1 ANKS1B NFASC TSC2 GRIK4 LRIT3 ADORA1 BNIP3 TRIM9 PAK1 LRP4 C4A C4B TACR3

1.79e-0386017016GO:0097447
GeneOntologyCellularComponentasymmetric synapse

PACSIN1 ANKS1B CRTAC1 TSC2 GRIK4 ADORA1 BNIP3 PAK1 PAK2 LRP4 MACF1

1.86e-0347717011GO:0032279
GeneOntologyCellularComponenthippocampal mossy fiber to CA3 synapse

UNC13B ANKS1B GRIK4 TNR

2.17e-03671704GO:0098686
GeneOntologyCellularComponentother organism part

C4A C4B

2.28e-0391702GO:0044217
GeneOntologyCellularComponentcalyx of Held

UNC13B ADORA1 UNC13A

3.10e-03361703GO:0044305
GeneOntologyCellularComponentbasement membrane

NPHS1 COL15A1 P3H1 LOXL1 ACAN

3.23e-031221705GO:0005604
GeneOntologyCellularComponentsynaptic vesicle

UNC13B DMXL2 SEPTIN4 HAP1 TRIM9 SLC18A1 SPHK1 UNC13A

3.24e-033001708GO:0008021
GeneOntologyCellularComponentcell cortex

UNC13B CEP85 SEPTIN4 FRYL PHLDB1 PDE4DIP MYO1F MACF1 UNC13A

3.43e-033711709GO:0005938
GeneOntologyCellularComponentunconventional myosin complex

MYO1F MYO18B

3.45e-03111702GO:0016461
GeneOntologyCellularComponentneuronal cell body

MPL SEPTIN4 APBB1 TSC2 GRIK4 LRIT3 ADORA1 LNPEP BTD ACAN LRP4 C4A C4B TACR3 KLC1

3.45e-0383517015GO:0043025
GeneOntologyCellularComponentCul4-RING E3 ubiquitin ligase complex

DCAF12L2 DCAF12L1 DCAF12

3.62e-03381703GO:0080008
GeneOntologyCellularComponentcell body

MPL SEPTIN4 APBB1 TSC2 GRIK4 LRIT3 ADORA1 TMEM132E LNPEP BTD ACAN LRP4 C4A C4B TACR3 KLC1

3.83e-0392917016GO:0044297
GeneOntologyCellularComponentpostsynaptic density

PACSIN1 ANKS1B CRTAC1 TSC2 GRIK4 BNIP3 PAK1 PAK2 LRP4 MACF1

3.93e-0345117010GO:0014069
GeneOntologyCellularComponentgrowth cone

HAP1 APBB1 CRTAC1 TSC2 ITGA3 PAK1 KLC1

3.99e-032451707GO:0030426
DomainFN3

MPL NPHS1 SPEG NFASC LRIT3 FANK1 PTPRC PTPRH TRIM9 TNR

6.93e-0618516810SM00060
DomainFN3

MPL NPHS1 SPEG NFASC LRIT3 FANK1 PTPRC PTPRH TRIM9 TNR

1.31e-0519916810PS50853
DomainFN3_dom

MPL NPHS1 SPEG NFASC LRIT3 FANK1 PTPRC PTPRH TRIM9 TNR

2.01e-0520916810IPR003961
DomainIg-like_fold

MPL NPHS1 STBD1 HLA-DOB SPEG NFASC EBF1 LRIT3 SLC4A2 TGM2 LY6G6F FANK1 PTPRC PTPRH TRIM9 VCAN NCAN TNR

6.90e-0570616818IPR013783
Domainfn3

MPL NPHS1 SPEG NFASC PTPRC PTPRH TRIM9 TNR

1.11e-041621688PF00041
DomainUnc-13

UNC13B UNC13A

2.40e-0431682IPR027080
Domain-

MPL NPHS1 STBD1 HLA-DOB SPEG NFASC EBF1 LRIT3 TGM2 LY6G6F FANK1 PTPRC TRIM9 VCAN NCAN TNR

3.28e-04663168162.60.40.10
DomainGal_mutarotase_SF_dom

MAN2C1 MAN2B1 GANAB

4.43e-04171683IPR011013
DomainMib_Herc2

MIB2 HERC2

4.77e-0441682IPR010606
DomainMIB_HERC2

MIB2 HERC2

4.77e-0441682PS51416
DomainMIB_HERC2

MIB2 HERC2

4.77e-0441682PF06701
DomainLysyl_oxidase

LOXL1 LOXL4

7.90e-0451682IPR001695
DomainMunc13_dom-2

UNC13B UNC13A

7.90e-0451682IPR014772
DomainAnaphylatoxin_comp_syst

C4A C4B

7.90e-0451682IPR018081
DomainGlyco_hydro_38_C

MAN2C1 MAN2B1

7.90e-0451682IPR011682
DomainAlpha-mann_mid

MAN2C1 MAN2B1

7.90e-0451682PF09261
DomainLYSYL_OXIDASE

LOXL1 LOXL4

7.90e-0451682PS00926
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

7.90e-0451682IPR001840
DomainMHD2

UNC13B UNC13A

7.90e-0451682PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13A

7.90e-0451682IPR019558
DomainLysyl_oxidase_CS

LOXL1 LOXL4

7.90e-0451682IPR019828
DomainGlyco_hydro_57/38_cen

MAN2C1 MAN2B1

7.90e-0451682IPR028995
DomainGlyco_hydro_38

MAN2C1 MAN2B1

7.90e-0451682PF01074
DomainMembr_traf_MHD

UNC13B UNC13A

7.90e-0451682PF10540
Domain-

MAN2C1 MAN2B1

7.90e-04516821.20.1270.50
Domain-

MAN2C1 MAN2B1

7.90e-04516823.20.110.10
DomainAlpha-mann_mid

MAN2C1 MAN2B1

7.90e-0451682SM00872
DomainGlyco_hydro_38_N

MAN2C1 MAN2B1

7.90e-0451682IPR000602
DomainGlyco_hydro_38/57_N

MAN2C1 MAN2B1

7.90e-0451682IPR027291
DomainGlyco_hydro_38_cen

MAN2C1 MAN2B1

7.90e-0451682IPR015341
DomainDUF1041

UNC13B UNC13A

7.90e-0451682SM01145
DomainGlyco_hydro_38C

MAN2C1 MAN2B1

7.90e-0451682PF07748
DomainLysyl_oxidase

LOXL1 LOXL4

7.90e-0451682PF01186
DomainWD40_repeat

DMXL2 DCAF12L2 WDFY4 DENND3 DCAF12L1 HERC2 MAPKBP1 WDFY1 DCAF12

8.15e-042721689IPR001680
DomainWD_REPEATS_1

DMXL2 DCAF12L2 WDFY4 DENND3 DCAF12L1 HERC2 MAPKBP1 WDFY1 DCAF12

9.50e-042781689PS00678
DomainWD_REPEATS_2

DMXL2 DCAF12L2 WDFY4 DENND3 DCAF12L1 HERC2 MAPKBP1 WDFY1 DCAF12

9.74e-042791689PS50082
DomainWD_REPEATS_REGION

DMXL2 DCAF12L2 WDFY4 DENND3 DCAF12L1 HERC2 MAPKBP1 WDFY1 DCAF12

9.74e-042791689PS50294
Domain-

EVPL MACF1

1.18e-03616823.90.1290.10
DomainPAK_BD

PAK1 PAK2

1.18e-0361682IPR033923
DomainWD40_repeat_dom

DMXL2 DCAF12L2 WDFY4 DENND3 DCAF12L1 MAPKBP1 HPS5 WDFY1 DCAF12

1.50e-032971689IPR017986
Domain-

DMGDH DPYD FMO1 GDI2

1.61e-035616843.50.50.60
DomainANATO

C4A C4B

1.64e-0371682SM00104
DomainMunc13_1

UNC13B UNC13A

1.64e-0371682IPR014770
DomainWASP_C

PAK1 PAK2

1.64e-0371682IPR011026
DomainMHD1

UNC13B UNC13A

1.64e-0371682PS51258
DomainPlectin

EVPL MACF1

1.64e-0371682PF00681
DomainANAPHYLATOXIN_2

C4A C4B

1.64e-0371682PS01178
DomainANAPHYLATOXIN_1

C4A C4B

1.64e-0371682PS01177
DomainDUF1041

UNC13B UNC13A

1.64e-0371682PF06292
DomainPlectin_repeat

EVPL MACF1

1.64e-0371682IPR001101
DomainANATO

C4A C4B

1.64e-0371682PF01821
DomainGlyco_hydro/deAcase_b/a-brl

MAN2C1 MAN2B1

1.64e-0371682IPR011330
DomainCAPS_dom

UNC13B UNC13A

1.64e-0371682IPR010439
DomainAnaphylatoxin/fibulin

C4A C4B

1.64e-0371682IPR000020
DomainPLEC

EVPL MACF1

1.64e-0371682SM00250
DomainFAD/NAD-binding_dom

DMGDH DPYD FMO1 GDI2

1.72e-03571684IPR023753
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

2.17e-0381682IPR019565
DomainThiol-ester_cl

C4A C4B

2.17e-0381682PF10569
DomainMacrogloblnA2_CS

C4A C4B

2.17e-0381682IPR019742
DomainWD40

DMXL2 DCAF12L2 WDFY4 DENND3 DCAF12L1 MAPKBP1 WDFY1 DCAF12

2.43e-032591688PF00400
PathwayREACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE

VCAN NCAN CSPG4

3.18e-0581193M27260
PathwayREACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS

VCAN NCAN CSPG4

3.18e-0581193M27261
PathwayREACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD

VCAN NCAN CSPG4

3.18e-0581193M27259
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL15A1 ADAMTS2 ITGA3 P3H1 LOXL1 ACAN VCAN NCAN LRP4 LOXL4 TNR

4.63e-0530011911M610
PathwayREACTOME_DERMATAN_SULFATE_BIOSYNTHESIS

VCAN NCAN CSPG4

9.21e-05111193M27105
PathwayREACTOME_CS_DS_DEGRADATION

VCAN NCAN CSPG4

1.99e-04141193M651
PathwaySIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES

TSC2 IRS1 PAK1 PAK2 IRS2

2.51e-04671195M295
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

UNC13B DMXL2 CFAP91 CEP85 MAGED1 APBB1 ANKS1B CRTAC1 TSC2 ARMCX4 KANK2 CEP350 SF3B1 WIZ TRIM9 PDE4DIP PAK1 PAK2 LRP4 MACF1 HERC2 ZNF606 LCOR SLX4 AGTPBP1

4.24e-0912851702535914814
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DMXL2 MAGED1 ANKS1B NFASC TSC2 ARMCX4 KANK2 GDI2 SF3B1 ZNF394 WIZ N4BP2 NCAN PDE4DIP PAK1 PAK2 MACF1 HERC2 TNR UNC13A KLC1

1.19e-089631702128671696
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC13B ACSL6 SPEG KLHL29 FCHSD2 PHLDB1 GANAB SETD5 ITSN2 PDE4DIP MACF1 MAPKBP1 AGTPBP1

1.21e-074071701312693553
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

UNC13B TPST2 MAN2B1 SPEG AKNA TSC2 IRS1 FRYL MIB2 ITGA3 PHLDB1 PNPLA6 WIZ SETD5 SPHK1 CSPG4 BANP LRP4 IRS2 HERC2 MAPKBP1

1.22e-0711051702135748872
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SART3 ACSL6 DMXL2 SEPTIN4 PACSIN1 ANKS1B NFASC KANK2 GDI2 PHLDB1 SF3B1 PNPLA6 TRIM9 VCAN NCAN ITSN2 PDE4DIP MACF1 C4A C4B TNR UNC13A AGTPBP1 KLC1

1.43e-0714311702437142655
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

ACSL6 HAP1 ANKS1B NFASC MIB2 TGM2 ACAN VCAN NCAN MYO1F MACF1 HERC2 TNR

2.26e-074301701332581705
Pubmed

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.

PTPRC C4A C4B

4.57e-074170319001138
Pubmed

Lecticans: organizers of the brain extracellular matrix.

ACAN VCAN NCAN

4.57e-074170310766023
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

TPST2 NPR1 COL15A1 GALNS MAN2B1 PIGS TSC2 ITGA3 SLC4A2 TGM2 GANAB LNPEP BTD P3H1 LOXL1 CSPG4 LRP4 C4A C1QTNF6 ADPGK DCAF12

4.76e-0712011702135696571
Pubmed

The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.

P3H1 ACAN VCAN NCAN CSPG4

6.53e-0734170532220631
Pubmed

The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.

ACAN VCAN TNR

1.14e-065170311038354
Pubmed

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.

ACAN VCAN NCAN

3.96e-067170321976490
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

COL15A1 ADAMTS2 CSF1 BTD LOXL1 ACAN VCAN C4A C4B

4.01e-06248170924006456
Pubmed

Rheb1 is required for mTORC1 and myelination in postnatal brain development.

TSC2 IRS1 CSPG4 IRS2

6.43e-0625170421238928
Pubmed

Functional proteomics mapping of a human signaling pathway.

NPR1 STBD1 RNF168 MAN2B1 RYR2 TGM2 SF3B1 PTPRC LNPEP CSPG4 PDE4DIP MACF1 HERC2

7.56e-065911701315231748
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

SART3 MAGED1 HAP1 APBB1 CEP350 ADORA1 SCMH1 PDE4DIP SCAF11 CREB3L3 MAPKBP1 ADPGK AGTPBP1

1.02e-056081701316713569
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

UNC13B DPYD MIB2 KANK2 F5 PHLDB1 SF3B1 MACF1 IRS2 MYO18B

1.25e-053611701026167880
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SART3 CAND2 PACSIN1 AKNA NFASC G2E3 NACAD TRIM9 LRP4 SCAF11 HPS5 LCOR

1.26e-055291701214621295
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DMXL2 PACSIN1 NFASC METTL13 PHLDB1 TRIM9 MACF1 HPS5

1.62e-05225170812168954
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

2.38e-052170222737222
Pubmed

Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouse.

VCAN CSPG4

2.38e-052170217900358
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

2.38e-052170216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

2.38e-052170215998580
Pubmed

Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2.

IRS1 IRS2

2.38e-052170217222321
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

2.38e-052170219062096
Pubmed

Activation of PAK1/2 during the shedding of platelet microvesicles.

PAK1 PAK2

2.38e-052170220523167
Pubmed

Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism.

ACE F5

2.38e-052170211122103
Pubmed

Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan.

VCAN CSPG4

2.38e-052170215609081
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

2.38e-052170219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

2.38e-05217022459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

2.38e-052170217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

2.38e-052170212207352
Pubmed

Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.

IRS1 IRS2

2.38e-052170233270683
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

2.38e-052170227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

2.38e-052170222387014
Pubmed

The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.

INSL5 SCMH1

2.38e-052170210524249
Pubmed

Regulation of insulin exocytosis by Munc13-1.

UNC13B UNC13A

2.38e-052170212871971
Pubmed

Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.

IRS1 IRS2

2.38e-052170215975995
Pubmed

Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2).

IRS1 IRS2

2.38e-052170224703981
Pubmed

Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.

UNC13B UNC13A

2.38e-052170217561838
Pubmed

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.

IRS1 IRS2

2.38e-052170227708333
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

2.38e-052170223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

2.38e-052170223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

2.38e-05217023037333
Pubmed

Impairment of bone healing by insulin receptor substrate-1 deficiency.

IRS1 IRS2

2.38e-052170214736890
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

2.38e-052170211726230
Pubmed

Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation.

TSC2 AKT1S1

2.38e-052170222090422
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

2.38e-05217024216347
Pubmed

Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.

IRS1 AKT1S1

2.38e-052170223460019
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

2.38e-05217026950384
Pubmed

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.

IRS1 IRS2

2.38e-052170221356519
Pubmed

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.

UNC13B UNC13A

2.38e-052170228489077
Pubmed

The study on the relationship between IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms and type 2 diabetes in the Kurdish ethnic group in West Iran.

IRS1 IRS2

2.38e-052170222994406
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

2.38e-05217028660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

2.38e-05217028428773
Pubmed

Identification and characterization of versican/PG-M aggregates in cartilage.

ACAN VCAN

2.38e-052170216648631
Pubmed

Evaluation of the roles of the Leiden V mutation and ACE I/D polymorphism in subtypes of ischaemic stroke.

ACE F5

2.38e-052170211596779
Pubmed

Caspase-mediated Cleavage of Insulin Receptor Substrate.

IRS1 IRS2

2.38e-052170215069074
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

2.38e-052170224638111
Pubmed

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.

UNC13B UNC13A

2.38e-052170210440375
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

2.38e-052170221345967
Pubmed

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

IRS1 IRS2

2.38e-052170219596788
Pubmed

Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.

UNC13B UNC13A

2.38e-052170222066784
Pubmed

Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.

UNC13B UNC13A

2.38e-052170232187536
Pubmed

Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.

IRS1 IRS2

2.38e-052170219259821
Pubmed

Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.

IRS1 IRS2

2.38e-052170212810606
Pubmed

Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.

IRS1 IRS2

2.38e-052170211522686
Pubmed

Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice.

NCAN CSPG4

2.38e-052170222628090
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

2.38e-05217022572548
Pubmed

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.

IRS1 IRS2

2.38e-052170234449768
Pubmed

The complement component C4 of mammals.

C4A C4B

2.38e-05217022302180
Pubmed

Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.

PAK1 PAK2

2.38e-052170215047871
Pubmed

Cleavage of the carboxyl tail from the G3 domain of aggrecan but not versican and identification of the amino acids involved in the degradation.

ACAN VCAN

2.38e-052170211932252
Pubmed

Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.

UNC13B UNC13A

2.38e-052170222814762
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

2.38e-052170222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

2.38e-052170218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

2.38e-052170229080553
Pubmed

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.

IRS1 IRS2

2.38e-052170229717275
Pubmed

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.

IRS1 IRS2

2.38e-052170211546755
Pubmed

Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.

IRS1 IRS2

2.38e-052170212475767
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

2.38e-05217026589636
Pubmed

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

IRS1 IRS2

2.38e-052170211872698
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

2.38e-052170225339671
Pubmed

Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.

IRS1 IRS2

2.38e-052170211259600
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

2.38e-052170217728371
Pubmed

Myelodysplastic Syndrome/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis with Cooccurrent SF3B1 and MPL Gene Mutations: A Case Report and Brief Review of the Literature.

MPL SF3B1

2.38e-052170231858134
Pubmed

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.

IRS1 IRS2

2.38e-052170212213887
Pubmed

Selective Insulin Resistance in the Kidney.

IRS1 IRS2

2.38e-052170227247938
Pubmed

Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.

IRS1 IRS2

2.38e-052170231666286
Pubmed

Structure and organization of the C4 genes.

C4A C4B

2.38e-05217026149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

2.38e-05217026149581
Pubmed

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

UNC13B UNC13A

2.38e-052170228426965
Pubmed

Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.

IRS1 IRS2

2.38e-052170234537327
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

2.38e-052170212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

2.38e-05217023542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

2.38e-05217022387317
Pubmed

Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.

UNC13B UNC13A

2.38e-052170223770256
Pubmed

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

IRS1 IRS2

2.38e-052170226991655
Pubmed

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.

IRS1 IRS2

2.38e-052170215572028
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

2.38e-052170216908004
InteractionSLC6A4 interactions

ACSL6 MAGED1 HAP1 ANKS1B NFASC MIB2 ITGA3 TGM2 ACAN VCAN NCAN MYO1F MACF1 HERC2 TNR

4.06e-0643716815int:SLC6A4
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CALR3 MAN2B1 KANK2 SLC5A5 PNPLA6 WIZ NFIC NCAN MYO1F CREB3L3 UNC13A

2.05e-0479717011chr19p13
Cytoband1p34

MPL INPP5B SCMH1

2.29e-043217031p34
Cytoband4p11

CWH43 FRYL

6.02e-041017024p11
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ACAN VCAN NCAN

9.22e-0741123574
GeneFamilyFibronectin type III domain containing

MPL NPHS1 NFASC FANK1 PTPRC PTPRH TRIM9 TNR

6.88e-061601128555
GeneFamilyUNC13 homologs

UNC13B UNC13A

2.26e-0441122836
GeneFamilyWD repeat domain containing

DMXL2 DCAF12L2 WDFY4 DENND3 DCAF12L1 MAPKBP1 WDFY1 DCAF12

2.27e-042621128362
GeneFamilyMannosidases alpha class 2

MAN2C1 MAN2B1

3.76e-04511221194
GeneFamilyEF-hand domain containing|Plakins

EVPL MACF1

1.04e-0381122939
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

1.33e-03911221234
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ACAN VCAN NCAN

2.08e-034111231298
GeneFamilyAdenosine receptors|V-set domain containing

NPHS1 LY6G6F ACAN VCAN NCAN

3.46e-031631125590
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ACAN VCAN NCAN

5.31e-035711231179
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

MIB2 HERC2

5.45e-0318112291
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1 PDE4DIP TACR3

3.76e-0818317097c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1 PDE4DIP TACR3

3.76e-081831709612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NPR1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1 PDE4DIP

4.12e-081851709b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLA-DOB ACE WDFY4 PTPRC PTPRH LNPEP MYO1F TNR

1.93e-0716017088dae9b0cf90a09acb196223f45a14680102630b2
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 COL15A1 HAP1 INPP5B ADORA1 LY6G6F PTPRC PNPLA6

3.07e-071701708c638dfde9ce30190abbe0caea1c3eb874af09857
ToppCell3'-Adult-LymphNode-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEPTIN4 APBB1 NFASC CSF1 LOXL1 CSPG4 LOXL4 ZNF606

3.99e-07176170856e19240f4a7b617a986e3c0854b757394e78251
ToppCell3'-Adult-LymphNode-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEPTIN4 APBB1 NFASC CSF1 LOXL1 CSPG4 LOXL4 ZNF606

3.99e-071761708c88b46fe29ae7606c8880a6ff0ebb85c0dfda8bd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC F5 PCED1B KLHL29 ADORA1 PDE4DIP TACR3

4.17e-0717717084d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD IRS1 F5 ADORA1 SHPK IRS2 CREB3L3

5.15e-07182170877ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD IRS1 F5 ADORA1 SHPK IRS2 CREB3L3

5.15e-0718217084921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD IRS1 F5 ADORA1 SHPK IRS2 CREB3L3

5.15e-071821708770ce9f3f4538d0181a0181543841bc964c68274
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NPR1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1

5.37e-071831708848fc6dd129150897ee339343e83c645b6e779eb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC F5 PCED1B KLHL29 ADORA1 PDE4DIP TACR3

5.37e-071831708eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD IRS1 F5 ADORA1 C4B IRS2 CREB3L3

5.37e-071831708d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1 PDE4DIP

5.83e-0718517089197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1 PDE4DIP

5.83e-071851708ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellIPF-Stromal-SMC|World / Disease state, Lineage and Cell class

SPEG NFASC EBF1 KANK2 RYR2 ACAN CSPG4 C4B

6.58e-071881708b66264e8f8d536ed2beec31e6746c687718f239b
ToppCellIPF-Stromal-SMC|IPF / Disease state, Lineage and Cell class

SPEG NFASC EBF1 KANK2 RYR2 ACAN CSPG4 C4B

6.58e-071881708e98b24c0de41285f01f7ac194ff0a1b59fd5c333
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 SPEG NFASC EBF1 KANK2 ACAN VCAN CSPG4

7.13e-07190170870c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CFAP91 CAND2 CWH43 INSL5 CATSPERG LCOR

7.35e-0782170601a4d47d9e0dee68a5277ed1534338cec80f75d1
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CFAP91 CAND2 CWH43 INSL5 CATSPERG LCOR

7.35e-07821706c1489097c291f413f3cfa5e26f8182ec872328fd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL15A1 SPEG NFASC EBF1 RYR2 ACAN CSPG4 UNC13A

7.42e-07191170804c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ADAMTS2 EBF1 ACE P3H1 LOXL1 VCAN C1QTNF6

7.71e-071921708beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 MAGED1 ADAMTS2 CSF1 LOXL1 LOXL4 C4B C1QTNF6

8.02e-071931708316ebdf15f75d88c348f909b643fcd315364ca84
ToppCelldroplet-Fat-Scat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 MAGED1 ADAMTS2 CSF1 LOXL1 LOXL4 C4B C1QTNF6

8.02e-0719317088dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 ANKS1B NFASC ITGA3 F5 KLHL29 ADORA1 TACR3

8.02e-0719317083eaa0461618582a1754400624350d269d24e750a
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 MAGED1 ADAMTS2 CSF1 LOXL1 LOXL4 C4B C1QTNF6

8.02e-0719317081afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

COL15A1 ADAMTS2 ANKS1B EBF1 KLHL29 PHLDB1 LOXL1 VCAN

8.34e-071941708d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NPR1 NFASC ITGA3 F5 ADORA1 LOXL1 VCAN

8.34e-07194170843eb677a76634bb9a48a40e0d607c4936ae64bcc
ToppCellE18.5-Mesenchymal-Mesenchymal_structural|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STBD1 MAGED1 ADAMTS2 SEPTIN4 TGM2 LOXL1 VCAN MACF1

9.01e-07196170897e26622d9582b092c18ff5b7e957818f99d9631
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STBD1 MAGED1 ADAMTS2 SEPTIN4 TGM2 LOXL1 VCAN MACF1

9.01e-071961708f429f045ba45e24717963315832150b12a115bfa
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYD DMXL2 ADAMTS2 PTPRC VCAN MYO1F PAK1 AGTPBP1

9.01e-071961708cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL15A1 MAN2B1 ADAMTS2 ZNF394 SPHK1 VCAN MYO1F IMPG2

9.36e-0719717084a6eff66a17c5e89bda61d887b736f5c62b93bd7
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX12 IRS1 FCHSD2 NFIC LRP4 C4A C1QTNF6

1.14e-061401707e442c46979d725ec82f525a001c46d971fcade4d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 KANK2 RYR2 ACAN CSPG4

1.98e-0615217070cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 KANK2 RYR2 ACAN CSPG4

1.98e-061521707ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 C1orf87 NFASC GRIK4 EBF1 TRIM9 VCAN

3.15e-0616317078e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 C1orf87 NFASC GRIK4 EBF1 TRIM9 VCAN

3.15e-061631707bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CAND2 ARMCX4 ACE METTL13 WIZ C1QTNF6 WDFY1

3.42e-06165170762457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1

3.85e-061681707315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG EBF1 DENND3 ADORA1 CSPG4 MYO18B UNC13A

4.16e-061701707cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG EBF1 DENND3 ADORA1 CSPG4 MYO18B UNC13A

4.16e-06170170799dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG EBF1 DENND3 ADORA1 CSPG4 MYO18B UNC13A

4.16e-0617017073a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC ITGA3 F5 PCED1B KLHL29 ADORA1

4.50e-0617217076c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

FMO1 SEPTIN4 IRX3 EBF1 WDFY4 CSF1 LRP4

4.85e-061741707430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKNA EBF1 WDFY4 PCED1B FCHSD2 PTPRC TNR

5.43e-061771707b07e6139618d888a9fd7cf43cad0d86a3f63e09e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKNA EBF1 WDFY4 PCED1B FCHSD2 PTPRC TNR

5.43e-0617717076376ec12322c04d5d37ec2fdc376700464cbc7fb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC F5 KLHL29 ADORA1 PDE4DIP TACR3

5.63e-061781707edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBXO40 COL15A1 ADAMTS2 EBF1 LOXL1 VCAN C1QTNF6

6.06e-06180170739ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCellMesenchymal_cells-Adipo-CAR|Mesenchymal_cells / Lineage and Cell class

SEPTIN4 IRX3 EBF1 TGM2 CSF1 SPHK1 C4B

6.28e-0618117071cfb03eb03a37b036b4eeacec69c9b8163af1ee4
ToppCellPericytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

COL15A1 SPEG NFASC EBF1 KANK2 ACAN CSPG4

6.51e-06182170746c213597445b1f4f09dc367f27702d24b201daf
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLA-DOB EBF1 PTPRC LNPEP ITSN2 MACF1 SCAF11

6.51e-061821707eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC F5 PCED1B KLHL29 ADORA1 PDE4DIP

6.75e-0618317073c516fe5083f02bad1f464ed284010b4131a833c
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEPTIN4 APBB1 CRTAC1 LY6G6F CCT6B LRP4 C4B

6.75e-061831707eb1f1dd12d1e4f1a7029b5396baada23f7c971ff
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSL6 INSL5 HAP1 APBB1 ANKS1B NFASC UNC13A

6.75e-061831707d26c7b79895de28961b8d68351f28d4bb531c75c
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPHS1 FMO1 APBB1 IRS1 GRIK4 EBF1 TMEM132E

6.75e-061831707bc24145855bf4d027a8058bf92bc796c10f241bb
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

NPHS1 NFASC F5 PCED1B KLHL29 ADORA1 PDE4DIP

6.75e-061831707fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC F5 PCED1B KLHL29 ADORA1 PDE4DIP

6.75e-0618317079c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPHS1 FMO1 APBB1 IRS1 GRIK4 EBF1 TMEM132E

6.75e-0618317074c325ee6da070513097a11445ec95b0415ffd8a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 NFASC F5 PCED1B KLHL29 ADORA1 PDE4DIP

7.00e-0618417077294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellMesenchymal_cells-Adipo-CAR|World / Lineage and Cell class

ADAMTS2 SEPTIN4 IRX3 EBF1 CSF1 LOXL1 C4B

7.51e-0618617076ca8ce7ced91d6308b7c056032ffec1b37c974bf
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 ANKS1B NFASC ITGA3 ADORA1 PDE4DIP TACR3

7.78e-06187170724c2a3962da364e46e98abeab5f8234376fa26bb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 KANK2 RYR2 ACAN CSPG4

8.05e-061881707b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCellFibroblast-A|World / shred on cell class and cell subclass (v4)

STBD1 MAGED1 ADAMTS2 SEPTIN4 LOXL1 VCAN MACF1

8.05e-0618817076740bed5fb8f45b6eea17041894b804214c2a4ae
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

COL15A1 CRTAC1 ITGA3 NACAD SPRED3 PHLDB1 LOXL1

8.33e-061891707473b01c9162b12b90a617c600238436177a0d18d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 KANK2 RYR2 ACAN CSPG4

8.33e-0618917077fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 KANK2 RYR2 ACAN CSPG4

8.33e-06189170706b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 RYR2 ACAN CSPG4 MYO18B

8.33e-061891707127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell(1)_Osterolineage_cells-(10)_OLC-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

ADAMTS2 CSF1 LOXL1 PAK1 LRP4 C1QTNF6 CREB3L3

8.33e-06189170746c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 RYR2 ACAN CSPG4 MYO18B

8.33e-0618917072cfb4d12f75678d1619f4743838a0e954bd57761
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ADAMTS2 ACE PHLDB1 CSF1 LOXL1 VCAN

8.63e-061901707bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ADAMTS2 ACE PHLDB1 CSF1 LOXL1 VCAN

8.63e-061901707e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ADAMTS2 ACE PHLDB1 CSF1 LOXL1 VCAN

8.63e-061901707ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCelldroplet-Heart-nan-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ADAMTS2 RYR2 LOXL1 VCAN PDE4DIP MYO18B

8.63e-06190170796a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HAP1 CRTAC1 ACAN VCAN CSPG4 TACR3 TNR

8.63e-0619017076c7e1086c0a274cd5527c3104106e372811c9905
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

COL15A1 ANKS1B EBF1 PHLDB1 SYTL4 TRIM9 NRK

8.63e-06190170712992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPEG ANKS1B IRS1 EBF1 KANK2 RYR2 LRP4

8.93e-06191170708042952431ca1a6fd7dfc13f36eb28643979598
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 RYR2 ACAN CSPG4 MYO18B

9.23e-061921707bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 RYR2 ACAN CSPG4 MYO18B

9.23e-061921707b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

COL15A1 EBF1 TRIM9 ACAN NRK CSPG4 LOXL4

9.23e-0619217073a6f2c255da46a0b0f5b657b0f56f3d7798ae85a
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 ANKS1B NFASC ITGA3 F5 KLHL29 ADORA1

9.23e-061921707ef0aba777072429a6ab7dcfcc305673975946580
ToppCellPericytes|World / lung cells shred on cell class, cell subclass, sample id

COL15A1 SPEG NFASC EBF1 KANK2 ACAN CSPG4

9.23e-061921707057ad22b878c0c5fb59ed1412ca13db945c57a5a
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYD DMXL2 PTPRC VCAN MYO1F PAK1 AGTPBP1

9.55e-06193170758e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

G2E3 FRYL CEP350 GANAB N4BP2 SCAF11 WDFY1

9.55e-061931707abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN4 SPEG NFASC EBF1 KANK2 ACAN CSPG4

9.88e-0619417075099e6ad7c19e5f8b73449d904aaefd97f1b1959
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN4 SPEG NFASC EBF1 KANK2 ACAN CSPG4

9.88e-06194170771734ef7b34ab33b349595368176fa0e1175d4d0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 RYR2 ACAN CSPG4 MYO18B

9.88e-0619417075c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellfacs-Heart-RA-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ADAMTS2 ACE KANK2 NFIC LOXL1 VCAN

9.88e-061941707bc945450b350f597c3ff910d3a14a533d90086a8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG NFASC EBF1 RYR2 ACAN CSPG4 MYO18B

9.88e-061941707ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL15A1 SPEG NFASC EBF1 KANK2 VCAN CSPG4

9.88e-061941707ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STBD1 MAGED1 ADAMTS2 SEPTIN4 LOXL1 VCAN MACF1

1.02e-051951707cbe518b465b4ef32797ae6b608219207c08493df
ToppCelldroplet-Limb_Muscle-MUSCLE-1m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 P3H1 ACAN NRK C1QTNF6 CREB3L3 WDFY1

1.02e-051951707fee9d13f48149cd5f921cfe4b8b3053cf6a6dbd2
ToppCellP03-Mesenchymal|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STBD1 MAGED1 ADAMTS2 SEPTIN4 LOXL1 VCAN MACF1

1.02e-0519517076180309c6ae278b996fd98c57461cbc129c028ba
ToppCellPND03-Mesenchymal-Mesenchymal_structural|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STBD1 MAGED1 ADAMTS2 SEPTIN4 LOXL1 VCAN MACF1

1.02e-051951707136b06b0931a69b1241101f68c01c44c70365fd9
ToppCellCOVID-19-Myeloid-Monocytes|COVID-19 / group, cell type (main and fine annotations)

DPYD DMXL2 ADAMTS2 PTPRC VCAN MYO1F AGTPBP1

1.06e-05196170704d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ADAMTS2 IRS1 ACE LOXL1 VCAN C1QTNF6

1.06e-05196170759b5b5a0c123d0423abd19c312514849004b903b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HAP1 CRTAC1 ACAN VCAN CSPG4 TACR3 TNR

1.06e-051961707f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCellKidney-Mesangial|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

SEPTIN4 SPEG NFASC EBF1 KANK2 ACAN CSPG4

1.06e-0519617072b2cbe7f96213b7ff50442593f31820d17a2ae94
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STBD1 MAGED1 ADAMTS2 SEPTIN4 LOXL1 VCAN MACF1

1.06e-05196170714246f00c90741a5f8683f377e22e3a7c99661b9
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STBD1 MAGED1 ADAMTS2 SEPTIN4 TGM2 LOXL1 MACF1

1.06e-051961707db64ab27374f82553ee577aec056141170f3656f
Diseasealpha-Mannosidosis

MAN2C1 MAN2B1

3.15e-0521662C0024748
DiseaseMYELODYSPLASTIC SYNDROME

MPL ACSL6 SF3B1 SPHK1 SLX4

3.87e-05671665C3463824
Diseaseinvasive lobular carcinoma, hormone replacement therapy

TMEM132E CCT6B

9.40e-0531662EFO_0000553, EFO_0003961
Diseasenon-arteritic anterior ischemic optic neuropathy (is_implicated_in)

ACE F5

3.11e-0451662DOID:0050864 (is_implicated_in)
Diseaserelapsing-remitting multiple sclerosis (is_implicated_in)

CSPG4 KLC1

3.11e-0451662DOID:2378 (is_implicated_in)
Diseasenephrotic syndrome (implicated_via_orthology)

NPHS1 ACE ITSN2

3.24e-04241663DOID:1184 (implicated_via_orthology)
Diseaseplatelet component distribution width

HLA-DOB PACSIN1 NUP210L CRTAC1 IRS1 METTL13 PTPRC PTPRH SYTL4 PAK2 MACF1 IRS2 DCAF12

3.64e-0475516613EFO_0007984
Diseasediastolic blood pressure, systolic blood pressure

UNC13B CEP85 SPEG RYR2 CEP350 KIAA1671 CSF1 N4BP2 LOXL1 ACAN LOXL4 KLC1

4.33e-0467016612EFO_0006335, EFO_0006336
Diseasesexual dimorphism measurement

CWH43 PACSIN1 INPP5B TSC2 FRYL KLHL29 HROB SLC18A1 SCMH1 NFIC LOXL1 ACAN MYO1F MACF1 MAPKBP1 LCOR

5.34e-04110616616EFO_0021796
DiseaseD dimer measurement

F5 LRP4 CATSPERG

6.35e-04301663EFO_0004507
Diseaseproteinuria (implicated_via_orthology)

NPHS1 ACE HPS5

6.35e-04301663DOID:576 (implicated_via_orthology)
DiseaseAutistic Disorder

FBXO40 DPYD TSC2 ACE WDFY4 BTD C4B

7.19e-042611667C0004352
Diseasetriacylglycerol 58:8 measurement

METTL13 TMEM132E CCT6B

1.00e-03351663EFO_0010442
Diseasebody fat distribution

RNF168 ADAMTS2 EBF1 LOXL1 ACAN VCAN

1.02e-032021666EFO_0004341
Diseaseamnestic disorder (implicated_via_orthology)

IRS1 IRS2

1.10e-0391662DOID:10914 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

DPYD MAN2C1 C1orf87 PIGS TECTA SLC5A5 TGM2 C5orf34 CSF1 PTPRC N4BP2 ITSN2 PAK1 MACF1 HERC2

1.13e-03107416615C0006142
Diseasemacrovascular complications of diabetes

F5 PDE4DIP

1.37e-03101662EFO_0010977
DiseaseSchizophrenia

ACSL6 DPYD ESS2 NFASC GRIK4 ACE ADORA1 TGM2 SLC18A1 NCAN PAK2 ZNF480 TACR3

1.53e-0388316613C0036341
Diseasecongestive heart failure (implicated_via_orthology)

ACE RYR2 BNIP3

1.59e-03411663DOID:6000 (implicated_via_orthology)
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

ACE SLC4A2

1.67e-03111662DOID:0110861 (biomarker_via_orthology)
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

DMGDH CRTAC1 CRY1 SLC18A1 NCAN MACF1

1.73e-032241666EFO_0004530, EFO_0008317
Diseasesystemic lupus erythematosus (implicated_via_orthology)

PTPRC C4A C4B

1.83e-03431663DOID:9074 (implicated_via_orthology)
DiseaseProteinuria

NPHS1 PAK1 PAK2

1.83e-03431663C0033687
Diseaseinsulin sensitivity measurement, glucose homeostasis measurement

IRS1 SETD5 PAK2

1.83e-03431663EFO_0004471, EFO_0006896
Diseasebody fat percentage

DPYD DMXL2 ANKS1B CRTAC1 IRS1 MIB2 EBF1 ACAN MACF1

1.85e-034881669EFO_0007800
DiseaseParoxysmal atrial fibrillation

CAND2 ACE SCMH1 PAK2 MYO18B

1.93e-031561665C0235480
Diseasefamilial atrial fibrillation

CAND2 ACE SCMH1 PAK2 MYO18B

1.93e-031561665C3468561
DiseasePersistent atrial fibrillation

CAND2 ACE SCMH1 PAK2 MYO18B

1.93e-031561665C2585653
DiseaseAtrial Fibrillation

CAND2 ACE SCMH1 PAK2 MYO18B

2.16e-031601665C0004238
Diseaselung disease (implicated_via_orthology)

ACE ADORA1

2.36e-03131662DOID:850 (implicated_via_orthology)
DiseaseDEAFNESS, AUTOSOMAL RECESSIVE (disorder)

DMXL2 TMEM132E

2.36e-03131662C1846647
Diseaseleukemia (is_implicated_in)

ACSL6 ACE

2.36e-03131662DOID:1240 (is_implicated_in)
DiseaseProstatic Neoplasms

COL15A1 IRS1 ACE SLC4A2 SLC5A5 BNIP3 SF3B1 PTPRC NFIC ITSN2

2.66e-0361616610C0033578
DiseaseMalignant neoplasm of prostate

COL15A1 IRS1 ACE SLC4A2 SLC5A5 BNIP3 SF3B1 PTPRC NFIC ITSN2

2.66e-0361616610C0376358
DiseaseQRS-T angle

SPEG RYR2 MYO18B CDCA4

3.07e-031061664EFO_0020097
Diseaseamyotrophic lateral sclerosis, age at onset

ANKS1B SLC18A1

3.15e-03151662EFO_0004847, MONDO_0004976
DiseaseMalignant mesothelioma

ADAMTS2 RYR2 SF3B1 CSF1

3.40e-031091664C0345967
Diseasewaist-hip ratio

DPYD DMXL2 COL15A1 CAND2 ADAMTS2 TRIM41 EBF1 DCAF12L2 INKA2 KLHL29 ADORA1 BTD LOXL1 CREB3L3 MAPKBP1

4.01e-03122616615EFO_0004343
Diseasebreast cancer (is_marker_for)

TSC2 CSF1 SETD5 LNPEP PAK1

4.03e-031851665DOID:1612 (is_marker_for)
Diseasecreatine kinase measurement

CAND2 EBF1 CSF1

4.51e-03591663EFO_0004534
Diseasemigraine disorder, type 2 diabetes mellitus

FRYL EBF1 INKA2

4.73e-03601663MONDO_0005148, MONDO_0005277
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

DMGDH SLC18A1 LRP4 MACF1

4.93e-031211664EFO_0008595, EFO_0020943
Diseaseresponse to methotrexate, neurotoxicity

PNPLA6 MACF1

5.05e-03191662EFO_0011057, GO_0031427
Diseaseexercise test

LRIT3 RYR2

5.59e-03201662EFO_0004328
Diseaseend stage renal disease (implicated_via_orthology)

IRS1 ACE

5.59e-03201662DOID:783 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
EGPGEWLTLDSQVIM

UNC13A

91

Q9UPW8
GTWLGDENNPEMRVR

BANP

216

Q8N9N5
ASNWRSAGGVSIEMD

CATSPERG

726

Q6ZRH7
SEVDGGENMTWAGAR

SLC4A2

861

P04920
MASGRPEELWEAVVG

AKT1S1

1

Q96B36
SSLSSWNGVPDVGMV

ADPGK

341

Q9BRR6
GSSMDDWEERQTSGR

VCAN

616

P13611
QGESSGDMAWEEVRG

CSPG4

991

Q6UVK1
ATWGETKGPEREMDA

CALR3

331

Q96L12
ESPGGEMEEAELTSW

C4B

346

P0C0L5
ASVTIDLEMWSPGGR

CREB3L3

146

Q68CJ9
GSSRPWQEVLKDMVG

ACE

576

P12821
AVERAWAANGSMGEP

ADORA1

151

P30542
GAGAWSMGTERDVTA

APCDD1L

381

Q8NCL9
PETMQTSEAWVFAGG

DPYD

466

Q12882
TDSDLPAGWMRVQDT

APBB1

251

O00213
GWVEMTEEELAPGRS

APBB1

376

O00213
GAQDGSVRMFEWTRP

DMXL2

2781

Q8TDJ6
GGTVTDGENITQRMW

NPR1

371

P16066
VKRTVESMSAPEWEG

DENND3

596

A2RUS2
PGETNASWVMKGTLE

AGTPBP1

921

Q9UPW5
MLGPEDQSSGRSWAD

ARMCX4

1341

Q5H9R4
TMEWQGEKGTTRVEP

ADAMTS2

136

O95450
DWSLEQMVRGSSDQP

C1orf87

146

Q8N0U7
TWGRGLPAGQAEVEM

CFAP91

226

Q7Z4T9
GGPNMWAITSEERTK

ITSN2

11

Q9NZM3
QAEVESEAGWGMVTP

P3H1

21

Q32P28
RTEDKQDGMPGRSWA

PARP2

61

Q9UGN5
SRRMDSVTWQEGKGP

LY6G6F

151

Q5SQ64
MNVPTESGELWILGD

PGA5

351

P0DJD9
LERQMAQTGDWGEPS

ANKS1B

1016

Q7Z6G8
TPEAGTMVTWVAGQE

NPHS1

141

O60500
EGAGPTRTVEWLNMR

PNPLA6

911

Q8IY17
SPPESMGRGRDWNVD

GDI2

61

P50395
WSGTPRAQEVVMSGV

LOXL4

481

Q96JB6
RTRMGIGDEAVSGPW

MAGED1

691

Q9Y5V3
ASLIWEARGMPEASG

KIAA1671

796

Q9BY89
VEPDDWTSTLMSRGR

INKA2

136

Q9NTI7
LRQVSEGMDGSADWP

HERC2

806

O95714
PGSRMWEVNFDGEVI

HPS5

241

Q9UPZ3
DNWREVAVGDSTGMA

LOXL1

126

Q08397
GSRDGTVALWRMDPD

DCAF12L2

211

Q5VW00
GVMQSWRIEGAHPED

DSG4

676

Q86SJ6
DIRGTLMTVETNWPG

HARBI1

181

Q96MB7
DMWLGVTVASQGPAG

ITGA3

121

P26006
PQVRGMDLSWESRTG

LCOR

256

Q96JN0
EGAEGRPWALSVTMS

KIF22

161

Q14807
VWNTAMPVGEEVTGG

PCED1B

161

Q96HM7
SVGEAVQKGWMPRES

EVPL

1916

Q92817
LRGEGWGSPQATAMV

FRYL

1351

O94915
WQDMPVDDVIGTLSG

NIPA2

271

Q8N8Q9
TQEGMSAVAGFSPEW

MACF1

941

O94854
MNKTASWEGREASPG

MANSC1

351

Q9H8J5
QTWTDEGTPSMRELR

LNPEP

806

Q9UIQ6
EEDFGRGPWLTMKST

HROB

446

Q8N3J3
QESPEEGVRWSIMSL

LRIT3

301

Q3SXY7
GRSAVTGPGEFWMQV

IRS1

226

P35568
TGPGEFWMQVDDSVV

IRS1

231

P35568
GEEDITVQTVTWPDM

ACAN

366

P16112
DASGEDRLWGGQMPT

INSL5

86

Q9Y5Q6
QEDLRWFRSTSGPGM

PACSIN1

281

Q9BY11
AVTGEFTGMPEQWAR

PAK1

91

Q13153
RSAVTGPGELWMQAD

IRS2

261

Q9Y4H2
GPGELWMQADDSVVA

IRS2

266

Q9Y4H2
GEGTRKNNMEITWTP

NFASC

736

O94856
VTGEFTGMPEQWARL

PAK2

91

Q13177
QTTFEGGMREPALAW

GALNS

311

P34059
LMSSGIWQRGKEEEG

G2E3

46

Q7L622
MTWGEVENTPLRVEG

ESS2

316

Q96DF8
APGMQEESLQGSWVE

BNIP3

6

Q12983
MQWLRVRESPGEATG

C1QTNF6

1

Q9BXI9
AGVMSTGPIRNGDWT

HLA-DOB

166

P13765
DSAMGTNWVPEEASG

CSF1

296

P09603
GSRDGSMGLWEVTDD

DCAF12

201

Q5T6F0
GSMIPTGETQARWAV

FMO1

376

Q01740
GDVRSMPDNSDAPWT

HAP1

91

P54257
SGEGPEVEMESWQKR

CEP85

561

Q6P2H3
AEGRTGFPWIDAIMT

CRY1

331

Q16526
TESGNWMIGSREERN

CEP350

161

Q5VT06
MAESWLRLSGAGPAE

FOXJ1

1

Q92949
TSGMTLEVPDQLGWE

BTD

501

P43251
MASSETEIRWAEPGL

AKNA

1

Q7Z591
KEEPLGSGMNAVRTW

EBF1

16

Q9UH73
AMETTGLAPWQDGVL

FBXO40

281

Q9UH90
SDGTWDVETPQGSMR

DMGDH

226

Q9UI17
SEPLMENGSGAWVRG

MAN2B1

826

O00754
GTWVEMDGNLPSGEA

MAN2C1

331

Q9NTJ4
VTGESGHMPAVRVWD

MAPKBP1

106

O60336
ISELTLMPVWTGDDG

INPP5B

806

P32019
LMPVWTGDDGSQLDS

INPP5B

811

P32019
SVGTWVRERDLGMPD

KANK2

266

Q63ZY3
GSRDGTVALWRMDPD

DCAF12L1

211

Q5VU92
TWPDGKMVSRNVASG

CRTAC1

506

Q9NQ79
ELSASENGDTPWMRE

FCHSD2

626

O94868
PQGRETEWLFGMDEG

METTL13

306

Q8N6R0
PEANGTWTGMVGELI

GRIK4

476

Q16099
GGTASSVDWIMEAAR

nan

51

Q1T7F1
KGWLEAMEEPTQTGS

CAND2

411

O75155
ITEVRWPSLDTDGTM

C5orf34

101

Q96MH7
SFDGRDIMTDPSWPQ

COL15A1

1306

P39059
MGPAWDQQEEGVSES

SART3

51

Q15020
GPQSGWMKQEEETSG

SCAF11

1171

Q99590
ETVTAGDMRVGWSRP

RYR2

1106

Q92736
MGNPRSVKEGLSWEE

CCDC103

201

Q8IW40
GDRIPAWTFDMNTGA

FAM171B

286

Q6P995
ESPGGEMEEAELTSW

C4A

346

P0C0L4
PDGGEEVSMSVEWNG

KLC1

536

Q07866
EVSMSVEWNGGVSGR

KLC1

541

Q07866
VGWVMDSRDRGPGTS

LARP1B

651

Q659C4
TWQSVKEMVFEGGPR

NUP210L

666

Q5VU65
MTWAPRSRTDEEGNA

IRX3

191

P78415
GEWTDDMAPALGRVG

MIB2

351

Q96AX9
EVWVGGTPLMNEDSI

IFNA6

126

P05013
SGPTSEGLMTWELDR

PIGS

411

Q96S52
WSVGITAIEMAEGAP

NRK

241

Q7Z2Y5
KTGEVATGMASRPNW

CWH43

181

Q9H720
VDVVDTGSGWTPLMR

FANK1

236

Q8TC84
GTGISNGEVVDWMDS

SYTL4

621

Q96C24
GNWDKTVDVSDMGPS

POLR3D

121

P05423
IPGTGDFNSKRDEMW

NUGGC

291

Q68CJ6
VGAGAGWDTPMRDED

TRIM41

76

Q8WV44
LNTGEPMVAADAGVW

CCT6B

481

Q92526
MDRSLGWQGNSVPED

SEPTIN4

1

O43236
SEGTDQVVTMLGPDW

TMEM132E

606

Q6IEE7
QDTGSPSGMRPWEDL

F5

896

P12259
GETPQTDVRWMSETG

GANAB

346

Q14697
WADLTNEVDMPGAGS

NCAN

541

O14594
WMVPTSVERLREGGS

SETD5

1166

Q9C0A6
EWGVERVMGSGSALS

SHPK

421

Q9UHJ6
GNEAWLESESMSPGD

SPATA31E1

996

Q6ZUB1
RQMGVTEWSVNGSPI

WIZ

1251

O95785
AGAISWGTATPMDVV

SLC25A48

226

Q6ZT89
EMVSVAWPTEGGDDL

IMPG2

876

Q9BZV3
PTSSSRNWTEDMEGG

NFIC

306

P08651
RNWTEDMEGGISSPV

NFIC

311

P08651
MATLPAAETWIDGGG

TACR3

1

P29371
SGRDPSSWTVEDVMQ

SCMH1

586

Q96GD3
PGRDEAATTWEKMGQ

SLX4

911

Q8IY92
EVMPSWAQKRGIEGT

ACSL6

606

Q9UKU0
EEMTQDGTWRTVAPQ

CDCA4

71

Q9BXL8
LQSSAWEMDGPRENR

CDCA4

141

Q9BXL8
DGRPAMSVLDLGESW

TECTA

476

O75443
GDGVSPMSWIGSVDI

TGM2

246

P21980
WTGHIPGDVVRDMAQ

TPST2

301

O60704
WPMSPGRESSVNGES

USP27X

241

A6NNY8
GSDAELGPWVMAARS

ZNF394

11

Q53GI3
LPKMGSVGDWEVTAE

ZSCAN20

211

P17040
AVVWTAGSQGPAMRD

ZSCAN32

201

Q9NX65
GTPETGAATPMDWQE

SPEG

1961

Q15772
SRNESLESPMGEWGF

STBD1

141

O95210
MEAVETGERPTFGAW

SLC5A5

1

Q92911
SRWDETPASQMGGST

SF3B1

336

O75533
TEMIAGDWRPSSIAD

SOX12

296

O15370
AVVMARDDSSGGWLP

SPRED3

6

Q2MJR0
GISDRSIELEWDGPM

TNR

336

Q92752
MEGPAWDTSQIIITG

WDFY4

3076

Q6ZS81
EGPGEWSTLEAETLM

UNC13B

91

O14795
AMGGSQPGELQISWE

MPL

141

P40238
EEPGVATQRLWESME

PHLDB1

666

Q86UU1
GEQGADSSIESPMPW

RNF168

286

Q8IYW5
QMTFGPSRWGLEDEE

MYO18B

881

Q8IUG5
DLERNPTGGADEWQM

MYO18B

1506

Q8IUG5
GMEAEVGEFPWQVSI

PRSS55

71

Q6UWB4
TEDQWGKGTLTPRMT

TRIM9

396

Q9C026
NSMLEQRREPWSGES

ZNF480

76

Q8WV37
WEAEAGGSRGQEMET

ZNF91

1166

Q05481
EVVNGLMERPDWETA

SPHK1

86

Q9NYA1
WPSMEEGTRAFGDVV

PTPRC

766

P08575
SWVREGMTDPRTQST

PTPRH

511

Q9HD43
SSDGGIAVWNMDVSR

WDFY1

261

Q8IWB7
WIMETATQREGNSGG

ZNF284

66

Q2VY69
VSWADSAVVMEEGSP

TSC2

1291

P49815
GALTDQSWGMTAVDP

ZNF606

11

Q8WXB4
AVEESVPSGIAWMND

SLC18A1

91

P54219
MRESDNPGTGPWVTT

KLHL29

136

Q96CT2
TDWGASPKIERAGMD

LRP4

876

O75096
MDSRWGGRSESINVT

MYO1F

326

O00160
WGLSPQGSMVDEREL

NACAD

251

O15069
IMGDWPSSDSLAQRE

N4BP2

881

Q86UW6
WDVMRPQKGSVSGDL

PDE4DIP

1811

Q5VU43