Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	super elongation complex	AFF2 AFF3	1.17e-04	6	59	2	GO:0032783
GeneOntologyCellularComponent	cell body fiber	ASS1 APC	4.24e-04	11	59	2	GO:0070852
GeneOntologyCellularComponent	transcription elongation factor complex	AFF2 CDK12 AFF3	5.32e-04	56	59	3	GO:0008023
GeneOntologyCellularComponent	beta-catenin-TCF complex	BCL9L LDB1	5.99e-04	13	59	2	GO:1990907
GeneOntologyCellularComponent	intercalated disc	SCN5A ATP1B1 PTK2	9.40e-04	68	59	3	GO:0014704
GeneOntologyCellularComponent	dendritic spine membrane	SHISA9 SHISA6	1.16e-03	18	59	2	GO:0032591
MousePheno	split notochord	LDB1 APC GDF3	1.32e-06	7	48	3	MP:0004713
MousePheno	rostral-caudal axis duplication	LDB1 APC GDF3	3.15e-06	9	48	3	MP:0012156
MousePheno	embryonic-extraembryonic boundary constriction	LDB1 APC GDF3	1.68e-05	15	48	3	MP:0012135
MousePheno	abnormal primitive streak formation	LDB1 MRPL22 CLPX GDF3 TLX2	4.65e-05	116	48	5	MP:0002230
MousePheno	rostral body truncation	LDB1 APC GDF3	4.84e-05	21	48	3	MP:0012157
MousePheno	abnormal primitive streak morphology	LDB1 MRPL22 APC CLPX GDF3 TLX2	6.09e-05	201	48	6	MP:0002231
MousePheno	abnormal notochord morphology	LDB1 APC GDF3 PTK2	6.28e-05	63	48	4	MP:0002825
MousePheno	abnormal embryonic tissue morphology	RYBP MRTFB LDB1 MRPL22 SCN5A APC TMOD1 CLPX ATP1B1 GDF3 DHX29 PTK2 TLX2	6.85e-05	1116	48	13	MP:0002085
MousePheno	embryonic lethality between implantation and placentation	RYBP MRPL22 CDK12 APC CLPX GDF3 DHX29 PTK2 TLX2	1.10e-04	565	48	9	MP:0009850
MousePheno	abnormal developmental patterning	LDB1 MRPL22 APC CLPX ATP1B1 GDF3 DHX29 PTK2 TLX2	1.30e-04	577	48	9	MP:0002084
MousePheno	abnormal foregut morphology	LDB1 APC PTK2	1.45e-04	30	48	3	MP:0000474
MousePheno	abnormal visceral yolk sac morphology	BCL9L MRTFB LDB1 TMOD1 ATP1B1 PTK2	1.47e-04	236	48	6	MP:0001718
MousePheno	abnormal gastrulation	MRPL22 APC CLPX ATP1B1 GDF3 DHX29 PTK2 TLX2	1.75e-04	469	48	8	MP:0001695
MousePheno	abnormal embryonic-extraembryonic boundary morphology	LDB1 APC GDF3	2.11e-04	34	48	3	MP:0003890
Domain	TF_AF4/FMR2	AFF2 AFF3	5.66e-05	4	58	2	IPR007797
Domain	AF-4	AFF2 AFF3	5.66e-05	4	58	2	PF05110
Domain	Shisa	SHISA9 SHISA6	3.36e-04	9	58	2	PF13908
Domain	Shisa	SHISA9 SHISA6	3.36e-04	9	58	2	IPR026910
Domain	Rap_GAP_dom	RALGAPB RAP1GAP2	5.12e-04	11	58	2	IPR000331
Domain	RAPGAP	RALGAPB RAP1GAP2	5.12e-04	11	58	2	PS50085
Domain	DUF1605	YTHDC2 DHX29	1.25e-03	17	58	2	IPR011709
Domain	OB_NTP_bind	YTHDC2 DHX29	1.25e-03	17	58	2	PF07717
Domain	HA2	YTHDC2 DHX29	1.40e-03	18	58	2	SM00847
Domain	HA2	YTHDC2 DHX29	1.40e-03	18	58	2	PF04408
Domain	Helicase-assoc_dom	YTHDC2 DHX29	1.40e-03	18	58	2	IPR007502
Domain	-	MRTFB PIAS2	1.92e-03	21	58	2	1.10.720.30
Domain	SAP	MRTFB PIAS2	2.10e-03	22	58	2	PF02037
Domain	SAP	MRTFB PIAS2	2.30e-03	23	58	2	SM00513
Domain	SAP	MRTFB PIAS2	2.72e-03	25	58	2	PS50800
Domain	SAP_dom	MRTFB PIAS2	2.72e-03	25	58	2	IPR003034
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BCL9L MRTFB PAXBP1 MRPL12 CDK12 RALGAPB APC SRP72 YTHDC2 GPATCH8 ATP1B1 DHX29 USP6NL	1.05e-06	1497	59	13	31527615
Pubmed	A 77-kDa protein associates with pp125FAK in mast cells and becomes tyrosine-phosphorylated by high affinity IgE receptor aggregation.	APC PTK2	2.83e-06	2	59	2	7744883
Pubmed	The m6A Reader YTHDC2 Suppresses Lung Adenocarcinoma Tumorigenesis by Destabilizing MRPL12.	MRPL12 YTHDC2	2.83e-06	2	59	2	38129673
Pubmed	The mouse Laf4 gene: exon/intron organization, cDNA sequence, alternative splicing, and expression during central nervous system development.	AFF2 AFF3	2.83e-06	2	59	2	12079280
Pubmed	Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells.	APC BTRC	8.48e-06	3	59	2	16798748
Pubmed	Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.	AFF2 AFF3	8.48e-06	3	59	2	21330300
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	A2M CDK12 RALGAPB APC SRP72 YTHDC2 CLPX PTK2	1.37e-05	650	59	8	38777146
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	BCL9L LDB1 DTX2 PIAS2 USP6NL	1.40e-05	180	59	5	35198878
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	A2M APC YTHDC2 DHX29 STK24 BTRC PTK2	1.57e-05	475	59	7	31040226
Pubmed	Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis.	RYBP L3MBTL1	1.69e-05	4	59	2	27081692
Pubmed	Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC.	APC BTRC	1.69e-05	4	59	2	12124804
Pubmed	Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.	APC PTK2	1.69e-05	4	59	2	20708588
Pubmed	Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.	AFF2 AFF3	1.69e-05	4	59	2	11923441
Pubmed	FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β.	APC PTK2	1.69e-05	4	59	2	26274564
Pubmed	Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.	SCN5A ATP1B1	1.69e-05	4	59	2	27988371
Pubmed	MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.	MRTFB APC	2.82e-05	5	59	2	31690663
Pubmed	Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.	APC BTRC	2.82e-05	5	59	2	19106159
Pubmed	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.	BCL9L APC	2.82e-05	5	59	2	30760710
Pubmed	APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.	APC BTRC	2.82e-05	5	59	2	19061640
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	MRPL12 APC GPATCH8 CLPX BTRC	4.17e-05	226	59	5	25900982
Pubmed	The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.	APC BTRC	4.23e-05	6	59	2	10074433
Pubmed	Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.	MYO1E PTK2	4.23e-05	6	59	2	28348210
Pubmed	An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.	APC BTRC	4.23e-05	6	59	2	10228155
Pubmed	Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.	APC PTK2	4.23e-05	6	59	2	18786926
Pubmed	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.	BCL9L APC	4.23e-05	6	59	2	30760720
Pubmed	p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.	MRPL22 MRPL12 CLPX	4.72e-05	41	59	3	22904065
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CACTIN PAXBP1 CDK12 RALGAPB YTHDC2 GPATCH8 DHX29 IQCK	4.73e-05	774	59	8	15302935
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	RYBP PRAM1 BRDT CDK12 GPATCH8 DHX29	5.68e-05	396	59	6	26687479
Pubmed	YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.	APC BTRC	5.91e-05	7	59	2	24976009
Pubmed	Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.	APC BTRC	5.91e-05	7	59	2	18281465
Pubmed	Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.	BTRC PTK2	5.91e-05	7	59	2	26506240
Pubmed	Functional proteomics mapping of a human signaling pathway.	A2M MRTFB LDB1 CDK12 SRP72 PIAS2 PCDH1	6.27e-05	591	59	7	15231748
Pubmed	Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.	APC BTRC	7.87e-05	8	59	2	34352208
Pubmed	Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.	BCL9L LDB1	7.87e-05	8	59	2	28296634
Pubmed	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.	APC BTRC	1.01e-04	9	59	2	12820959
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	CACTIN MRTFB CDK12 YTHDC2 PIAS2	1.20e-04	283	59	5	30585729
Pubmed	Recombination suppression by heterozygous Robertsonian chromosomes in the mouse.	PGM2 SGK3	1.26e-04	10	59	2	8454207
Pubmed	Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.	MRTFB SCN5A ATP1B1	1.27e-04	57	59	3	24952745
Pubmed	Human transcription factor protein interaction networks.	RYBP BCL9L LDB1 MRPL22 MRPL12 SRP72 GPATCH8 CLPX PIAS2 TLX2	1.33e-04	1429	59	10	35140242
Pubmed	The LMO2 oncogene regulates DNA replication in hematopoietic cells.	CACTIN LDB1 WDR46	1.34e-04	58	59	3	26764384
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	RYBP CDK12 AFF3 GPATCH8 STK24 BTRC PTK2 SGK3	1.45e-04	910	59	8	36736316
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	CACTIN PAXBP1 MRPL22 MRPL12 CDK12 SRP72 YTHDC2	1.47e-04	678	59	7	30209976
Pubmed	Common variants at ten loci modulate the QT interval duration in the QTSCD Study.	SCN5A ATP1B1	1.54e-04	11	59	2	19305409
Pubmed	Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.	APC BTRC	1.85e-04	12	59	2	22682247
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	MRPL22 CDK12 RAB3GAP2 WDR46 YTHDC2 CLPX DHX29	1.85e-04	704	59	7	29955894
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SHISA9 MRTFB LDB1 LPP AFF3 RALGAPB ASS1 SELENON PCDH1 PTK2	1.86e-04	1489	59	10	28611215
Pubmed	An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.	LDB1 BTRC	2.54e-04	14	59	2	23453598
Pubmed	Tagging genes with cassette-exchange sites.	MRPL12 CDK12 GPATCH8 DHX29 PTK2	2.63e-04	335	59	5	15741177
Pubmed	Integrin signalling regulates YAP and TAZ to control skin homeostasis.	APC PTK2	2.93e-04	15	59	2	26989177
Pubmed	USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.	APC BTRC	3.34e-04	16	59	2	29045831
Pubmed	The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome.	ASS1 ATP1B1	3.34e-04	16	59	2	23022198
Pubmed	The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.	APC BTRC	3.34e-04	16	59	2	19576224
Pubmed	Armc5 deletion causes developmental defects and compromises T-cell immune responses.	RIPOR2 STK24	3.79e-04	17	59	2	28169274
Pubmed	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.	APC BTRC	3.79e-04	17	59	2	17510365
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	MRTFB LPP PCDH1 DHX29 STK24 USP6NL	3.89e-04	565	59	6	25468996
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CACTIN MRPL22 WDR46 SRP72 YTHDC2 GPATCH8 DHX29	4.22e-04	807	59	7	22681889
Pubmed	Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort.	APC BTRC	4.25e-04	18	59	2	20844743
Pubmed	Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.	LORICRIN APC	4.75e-04	19	59	2	17002498
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	A2M CACTIN PAXBP1 MYO1E CDK12 TMOD1 SRP72 CLPX ATP1B1	4.76e-04	1371	59	9	36244648
Pubmed	Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.	LORICRIN BTRC	5.27e-04	20	59	2	12702649
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MRTFB CDK12 RAB3GAP2 RALGAPB	5.87e-04	225	59	4	12168954
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	MYO1E MRPL22 RAB3GAP2 YTHDC2 HDGFL3	5.90e-04	400	59	5	35013556
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RIPOR2 RAB3GAP2 RALGAPB RAP1GAP2 GPATCH8	6.38e-04	407	59	5	12693553
Pubmed	Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.	AFF2 AFF3	6.39e-04	22	59	2	16024815
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	APC YTHDC2 CLPX BTRC	6.59e-04	232	59	4	25515538
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	LDB1 MYO1E TMOD1 SRP72 YTHDC2 CLPX ATP1B1 DHX29 BTRC	6.77e-04	1440	59	9	30833792
Pubmed	ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification.	LORICRIN DTX2	7.00e-04	23	59	2	38582368
Pubmed	High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.	SHISA9 SHISA6	7.62e-04	24	59	2	22632720
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	BRDT SRP72 STK24	7.90e-04	106	59	3	18654987
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	PRAM1 WDR46 SRP72 CLPX	8.07e-04	245	59	4	35652658
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	RYBP CDK12 AFF3 STK24 BTRC	8.34e-04	432	59	5	23455922
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CACTIN PAXBP1 MRPL22 MRPL12 RAB3GAP2 RALGAPB CLPX DHX29 USP6NL	8.51e-04	1487	59	9	33957083
Pubmed	The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.	MRPL22 MRPL12	8.96e-04	26	59	2	11551941
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	BCL9L RALGAPB ASS1 APC STK24	9.61e-04	446	59	5	24255178
Pubmed	Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation.	MRPL22 CLPX	1.04e-03	28	59	2	32376682
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	LPP APC YTHDC2 USP6NL	1.05e-03	263	59	4	34702444
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	AFF2 RAB3GAP2 CLPX CMYA5 DHX29 USP6NL	1.07e-03	686	59	6	29987050
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	BCL9L MYO1E CDK12 DTX2 GPATCH8	1.07e-03	457	59	5	32344865
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	RAB3GAP2 LPP APC TMOD1 PIAS2 SGK3	1.09e-03	689	59	6	36543142
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	CACTIN MYO1E MRPL22 WDR46 ASS1 SRP72 USP6NL	1.09e-03	949	59	7	36574265
Pubmed	The protein interaction landscape of the human CMGC kinase group.	A2M CDK12 AFF3 APC GPATCH8 PTK2	1.14e-03	695	59	6	23602568
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RAB3GAP2 APC SRP72 YTHDC2 DHX29 USP6NL	1.26e-03	708	59	6	39231216
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	PAXBP1 MRPL22 CDK12 YTHDC2 GPATCH8 DHX29	1.30e-03	713	59	6	29802200
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ATP1B1 PCDH1 PTK2 SHISA6	1.34e-03	281	59	4	28706196
Pubmed	A human MAP kinase interactome.	RIPOR2 APC RAP1GAP2 PIAS2 PTK2	1.41e-03	486	59	5	20936779
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CACTIN RAB3GAP2 GPATCH8 CLPX CMYA5 PKD1L3 STK24 PTK2	1.41e-03	1284	59	8	17353931
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MYO1E WDR46 APC YTHDC2 DHX29 PTK2	1.41e-03	724	59	6	36232890
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	LDB1 MYO1E APC RAP1GAP2 CMYA5 PIAS2 BTRC PTK2	1.41e-03	1285	59	8	35914814
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	BCL9L APC	1.53e-03	34	59	2	30894540
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	RYBP MRTFB SPAG17	1.62e-03	136	59	3	25429064
Pubmed	Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors.	APC BTRC	1.62e-03	35	59	2	28808228
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	CACTIN MRTFB PAXBP1 MRPL12 CDK12	1.68e-03	506	59	5	30890647
Cytoband	16p13.12	SHISA9 MRTFB	7.26e-05	10	59	2	16p13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr5q22	APC YTHDC2	2.65e-03	59	59	2	chr5q22
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF2 AFF3	2.57e-05	4	38	2	1145
GeneFamily	Shisa family members	SHISA9 SHISA6	1.19e-04	8	38	2	742
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF2 AFF3	1.53e-04	9	38	2	1280
Coexpression	GSE3039_CD4_TCELL_VS_B2_BCELL_DN	A2M MRTFB MYO1E LPP ASS1 PTK2	5.89e-06	200	59	6	M6464
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	RIPOR2 MYO1E AFF3 USP6NL PTK2	5.17e-06	189	59	5	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	moderate-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RIPOR2 MYO1E AFF3 USP6NL PTK2	5.58e-06	192	59	5	ae3727503c3b9f4695e565fd3161cc33b898f349
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPST1 SCN5A ASS1 TMOD1 TLX2	6.48e-06	198	59	5	b58138581f1a9073267d64c1211c5b9b4de71d3e
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRAM1 RIPOR2 RAB3GAP2 DHX29	2.93e-05	133	59	4	f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRAM1 RIPOR2 RAB3GAP2 DHX29	2.93e-05	133	59	4	292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRAM1 RAP1GAP2 GDF3 PRR7	4.68e-05	150	59	4	34774b015adecc2be56a471fda8994e89a6ad93e
ToppCell	CV-Healthy-3\|Healthy / Virus stimulation, Condition and Cluster	CACTIN PAXBP1 PIAS2 IQCK	5.19e-05	154	59	4	26bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 CMYA5 ATP1B1	5.59e-05	157	59	4	9021900d9b1a71210c9c414a9d165eaf399eb607
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 CMYA5 ATP1B1	5.59e-05	157	59	4	c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCell	CV-Healthy-3\|CV / Virus stimulation, Condition and Cluster	CACTIN PAXBP1 PIAS2 IQCK	6.17e-05	161	59	4	fd4a79385ea967b9900dc76a3add813b894a3a28
ToppCell	Monocytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	7.61e-05	170	59	4	4e93b66b3033e6e4d5f6d2f41974623a53108f5e
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	A2M MRTFB MYO1E LPP	7.79e-05	171	59	4	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	wk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SHISA9 SCN5A BEND4 TLX2	8.90e-05	177	59	4	15a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	RIPOR2 AFF3 BEND4 USP6NL	8.90e-05	177	59	4	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MRTFB RAP1GAP2 TMOD1 EXTL1	9.70e-05	181	59	4	58f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCell	E18.5-samps\|World / Age Group, Lineage, Cell class and subclass	ASS1 BEND4 ATP1B1 PGM2	9.91e-05	182	59	4	9649f15858d1ede73e068afc59df3ac367b49687
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	A2M MRTFB LPP SHISA6	1.06e-04	185	59	4	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	10x5'-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	RIPOR2 AFF3 USP6NL PTK2	1.08e-04	186	59	4	a5c0bd4f6a7542f67d478dcdc0645ae6d927a395
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MRTFB RAP1GAP2 EXTL1 PTK2	1.08e-04	186	59	4	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	COVID_vent-Myeloid-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MYO1E AFF3 ATP1B1 PTK2	1.08e-04	186	59	4	63a5cdd3f60681762a218be32db84be8f29b88fd
ToppCell	10x5'-Liver-Lymphocytic_B-Naive_B_cells\|Liver / Manually curated celltypes from each tissue	MYO1E AFF3 BEND4 USP6NL	1.08e-04	186	59	4	23efdcedbe67f5e6c59106e052f570cd0338f1c1
ToppCell	COVID_vent-Myeloid-Dendritic-cDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MYO1E AFF3 ATP1B1 PTK2	1.08e-04	186	59	4	39457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	MYO1E AFF3 USP6NL PTK2	1.10e-04	187	59	4	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	SCN5A AFF3 RAP1GAP2 CMYA5	1.12e-04	188	59	4	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	wk_08-11-Epithelial-PNS-MFNG+_DBH+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SHISA9 SCN5A ASS1 TLX2	1.12e-04	188	59	4	d3d7d21d4fa39ac4106a164652673de1bef8662d
ToppCell	Control-Myeloid-Monocytes\|Control / group, cell type (main and fine annotations)	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.15e-04	189	59	4	3335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCell	3'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP2 SELENON STK24 PTK2	1.15e-04	189	59	4	7dad62bd50c197838058e89abd0ee387de3e83cd
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 EXTL1 CMYA5	1.15e-04	189	59	4	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	HSPCs-Ery_prog.\|HSPCs / Lineage and Cell class	LDB1 WDR46 ASS1 GDF3	1.15e-04	189	59	4	37d2c45debed1564a40a1085b8b310c50923b9e7
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	A2M RIPOR2 AFF2 PCDH1	1.15e-04	189	59	4	9c2492c38f27e4c699b40680652e4c64911cce52
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 EXTL1 CMYA5	1.15e-04	189	59	4	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCN5A ASS1 TMOD1 TLX2	1.17e-04	190	59	4	bdbfaced785db79ff965f332759be258dbf743cf
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 CMYA5 ATP1B1	1.19e-04	191	59	4	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHISA9 TPST1 MYO1E RAP1GAP2	1.19e-04	191	59	4	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMOD1 EXTL1 CMYA5 ATP1B1	1.19e-04	191	59	4	97fb4232417a39801e87725755fd16a57c250209
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHISA9 TPST1 MYO1E RAP1GAP2	1.19e-04	191	59	4	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMOD1 EXTL1 CMYA5 ATP1B1	1.19e-04	191	59	4	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 CMYA5 ATP1B1	1.19e-04	191	59	4	715f5b449b8e075959c05a5b38389df319663164
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SHISA9 ASS1 PCDH1 TLX2	1.22e-04	192	59	4	3fc7a661ef39286abfd82ed8ab580011f01cb8fd
ToppCell	11.5-Airway-Epithelial-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	SHISA9 SCN5A TMOD1 TLX2	1.22e-04	192	59	4	a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M RIPOR2 MRTFB PTK2	1.24e-04	193	59	4	a9349ed5f3c34dcf817b3e84737e5946922ddff3
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	RIPOR2 MYO1E USP6NL PTK2	1.24e-04	193	59	4	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	B_cells-Activate_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	RIPOR2 AFF3 BEND4 USP6NL	1.24e-04	193	59	4	b6da81920cf2e55f87ec8d4b2b5530cbf7ba2155
ToppCell	HSPCs-Ery_prog.\|World / Lineage and Cell class	LDB1 WDR46 ASS1 GDF3	1.24e-04	193	59	4	484c2e0daedc6cb0d50d164add8c1658123a60f9
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M RIPOR2 MRTFB PTK2	1.27e-04	194	59	4	7a7406c3b021aeafde423d20290c681c3e8ea0a6
ToppCell	nucseq-Immune-Immune_Myeloid-pMON-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.27e-04	194	59	4	e237384b02be460d44eeada3026a5691c66f6fc1
ToppCell	nucseq-Immune-Immune_Myeloid-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.27e-04	194	59	4	0bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M RIPOR2 MRTFB PTK2	1.29e-04	195	59	4	815ac5dacd382b11abb32011ed1c0635b0ddc779
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M RIPOR2 MRTFB PTK2	1.29e-04	195	59	4	9b3fa1d42ec5aa2911f27a99cd8b57714c6bd604
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.29e-04	195	59	4	10ce1b6961f10372d1f65388cbf3626a5fcd6840
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.32e-04	196	59	4	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	Adult-Immune-monocyte\|Adult / Lineage, Cell type, age group and donor	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.32e-04	196	59	4	3ef193c5180de3137daf886492e74fc574bc9767
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M RIPOR2 MRTFB PTK2	1.32e-04	196	59	4	624f700daea48d9bad4cc554f4776bd809ae1e54
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SHISA9 ASS1 PCDH1 TLX2	1.32e-04	196	59	4	e874aa82a20bb59582c8cd7f8d30b2ed02903a85
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 CMYA5 ATP1B1	1.32e-04	196	59	4	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN5A TMOD1 CMYA5 ATP1B1	1.32e-04	196	59	4	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	nucseq-Endothelial-Endothelial_Vascular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MRTFB AFF3 PCDH1 PTK2	1.32e-04	196	59	4	686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCell	Fetal_29-31_weeks-Immune-monocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.34e-04	197	59	4	48a8169a4d33c6a68d66bcd936861c75cb4b60ef
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|lung / Disease (COVID-19 only), tissue and cell type	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.34e-04	197	59	4	a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell	3'-Adult-SmallIntestine\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M RIPOR2 AFF2 AFF3	1.34e-04	197	59	4	1614bc5f41fd2c8385e58ed6b87ef1536421f29a
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.34e-04	197	59	4	8b9a88fb671d5c2b25d291c851e2b8a478f2610c
ToppCell	distal-Hematologic-Nonclassical_Monocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.34e-04	197	59	4	e817c1a8549e403e723b1b6c73cdb04f1179909d
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.37e-04	198	59	4	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	PBMC\|World / Compartment, Disease Groups and Clusters	RIPOR2 MRPL12 AFF3 SRP72	1.37e-04	198	59	4	84f5b43dad0c57556171dbc0b799735654582ecf
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPST1 ASS1 TMOD1 TLX2	1.37e-04	198	59	4	328f1d5d8168e05edd301d3a0f2eb5c6cd1c67c8
ToppCell	Immune-monocyte\|World / Lineage, Cell type, age group and donor	PRAM1 RIPOR2 SLC24A4 RAP1GAP2	1.37e-04	198	59	4	d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B\|GI_large-bowel / Manually curated celltypes from each tissue	RIPOR2 AFF3 USP6NL PTK2	1.37e-04	198	59	4	4fac7cdc93dc2037bae41f350b332c30b79c13fb
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Capillary\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	A2M MRTFB AFF3 PCDH1	1.40e-04	199	59	4	3fea92affacd4c1f588fa81807df35d6c69b7241
ToppCell	severe-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	AFF3 BEND4 USP6NL PTK2	1.40e-04	199	59	4	17283d75a2a900369f63ed02996e7ede97f46140
ToppCell	Endothelial_cells-Endothelial-A\|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id	A2M MRTFB ASS1 PCDH1	1.40e-04	199	59	4	2a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Capillary-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	A2M MRTFB AFF3 PCDH1	1.40e-04	199	59	4	993999adf346b4fd557989bc53c17eb0ccb996c9
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MRTFB LPP ASS1 CMYA5	1.40e-04	199	59	4	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	control-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MRTFB LPP ASS1 CMYA5	1.40e-04	199	59	4	3d01f90ffd271ca00129192787e4921bdca7e01e
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Capillary\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	A2M MRTFB AFF3 PCDH1	1.40e-04	199	59	4	89f4db619fbed90f7fdf6ece7a671e514b5c6d76
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MRTFB LPP ASS1 CMYA5	1.40e-04	199	59	4	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	severe-B_intermediate\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	AFF3 BEND4 USP6NL PTK2	1.42e-04	200	59	4	6d0ac3d00400dd5657ee266f7b885381bf790ce1
ToppCell	Biopsy_Other_PF-Endothelial-Endothelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	A2M MRTFB ASS1 PCDH1	1.42e-04	200	59	4	40d57a383c79d3365e033d08efd9371f0bc5bf55
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	AFF3 BEND4 USP6NL PTK2	1.42e-04	200	59	4	fe815824e9e4be3f3db73610e3814a7fd533da65
Drug	Rifampicin [13292-46-1]; Up 200; 4.8uM; HL60; HT_HG-U133A	A2M LDB1 L3MBTL1 MYO1E SCN5A APC PIAS2	7.87e-07	198	59	7	2487_UP
Drug	Simvastatin [79902-63-9]; Up 200; 9.6uM; HL60; HT_HG-U133A	A2M TPST1 RIPOR2 L3MBTL1 AFF2 TMOD1	8.89e-06	187	59	6	3002_UP
Drug	Prednisolone [50-24-8]; Up 200; 11uM; HL60; HT_HG-U133A	TPST1 RIPOR2 L3MBTL1 AFF3 TMOD1 PRR7	1.00e-05	191	59	6	2393_UP
Drug	Nitrendipine [39562-70-4]; Up 200; 11uM; HL60; HT_HG-U133A	LDB1 L3MBTL1 SCN5A RAP1GAP2 USP6NL PRR7	1.03e-05	192	59	6	3087_UP
Drug	Loracarbef [121961-22-6]; Up 200; 10.8uM; PC3; HT_HG-U133A	RIPOR2 L3MBTL1 AFF2 RAB3GAP2 EXTL1 TLX2	1.13e-05	195	59	6	5073_UP
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; PC3; HT_HG-U133A	LDB1 AFF2 LPP APC BTRC TLX2	1.20e-05	197	59	6	4642_DN
Drug	Sisomicin sulfate [53179-09-2]; Up 200; 2.8uM; HL60; HT_HG-U133A	MRTFB L3MBTL1 AFF2 TMOD1 BTRC HDGFL3	1.23e-05	198	59	6	2493_UP
Drug	fluphenazine dihydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	RAB3GAP2 LPP AFF3 APC TMOD1 PTK2	1.23e-05	198	59	6	6196_DN
Drug	Sulfabenzamide [127-71-9]; Down 200; 14.4uM; HL60; HT_HG-U133A	A2M LDB1 AFF2 TMOD1 ATP1B1 STK24	1.23e-05	198	59	6	2159_DN
Drug	(-)-Cinchonidine [485-71-2]; Up 200; 13.6uM; HL60; HG-U133A	L3MBTL1 SCN5A RALGAPB PIAS2 PTK2 HDGFL3	1.27e-05	199	59	6	1780_UP
Drug	Flucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; HL60; HT_HG-U133A	CACTIN L3MBTL1 LPP APC RAP1GAP2 IQCK	1.27e-05	199	59	6	3128_DN
Drug	Yohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; HL60; HT_HG-U133A	CACTIN LDB1 L3MBTL1 AFF2 MYO1E TMOD1	1.27e-05	199	59	6	2147_DN
Drug	alpha-estradiol; Up 200; 0.01uM; PC3; HG-U133A	RYBP TPST1 AFF2 CDK12 TMOD1 YTHDC2	1.30e-05	200	59	6	702_UP
Drug	AC1NRD87	DTX2 CLPX TLX2	6.38e-05	30	59	3	CID005289396
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; PC3; HT_HG-U133A	MRTFB MYO1E LPP APC PTK2	9.56e-05	177	59	5	4652_DN
Drug	colcemid; Up 200; 11.7uM; MCF7; HT_HG-U133A_EA	RAP1GAP2 GPATCH8 USP6NL PTK2 PRR7	1.33e-04	190	59	5	1103_UP
Drug	Rimexolone [49697-38-3]; Up 200; 10.8uM; HL60; HT_HG-U133A	TPST1 TMOD1 YTHDC2 STK24 PRR7	1.37e-04	191	59	5	2955_UP
Drug	Nifuroxazide [965-52-6]; Down 200; 14.6uM; PC3; HT_HG-U133A	AFF2 RAB3GAP2 APC PCDH1 BTRC	1.44e-04	193	59	5	4253_DN
Drug	Nortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; HL60; HT_HG-U133A	TPST1 MRTFB RAB3GAP2 SCN5A BTRC	1.47e-04	194	59	5	2391_UP
Drug	Etanidazole [22668-01-5]; Down 200; 18.6uM; MCF7; HT_HG-U133A	TMOD1 YTHDC2 PCDH1 BTRC PTK2	1.47e-04	194	59	5	6072_DN
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; HL60; HT_HG-U133A	MYO1E RAB3GAP2 APC PTK2 HDGFL3	1.47e-04	194	59	5	1294_UP
Drug	ICI 182,780; Down 200; 1uM; HL60; HT_HG-U133A	TPST1 CACTIN MRTFB AFF3 APC	1.47e-04	194	59	5	6165_DN
Drug	pioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A	LDB1 L3MBTL1 TMOD1 STK24 BTRC	1.51e-04	195	59	5	5977_DN
Drug	Cetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; HL60; HT_HG-U133A	CACTIN LDB1 APC RAP1GAP2 PRR7	1.51e-04	195	59	5	2468_DN
Drug	Luteolin [491-70-3]; Down 200; 14uM; MCF7; HT_HG-U133A	TPST1 LDB1 RALGAPB APC BTRC	1.51e-04	195	59	5	5004_DN
Drug	Tenoxicam [59804-37-4]; Up 200; 11.8uM; HL60; HT_HG-U133A	AFF2 SCN5A APC TMOD1 BTRC	1.51e-04	195	59	5	2501_UP
Drug	Methimazole [60-56-0]; Up 200; 35uM; HL60; HT_HG-U133A	TPST1 L3MBTL1 RAP1GAP2 TMOD1 BTRC	1.54e-04	196	59	5	2570_UP
Drug	Fluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; PC3; HT_HG-U133A	L3MBTL1 LPP APC BTRC PRR7	1.54e-04	196	59	5	5741_DN
Drug	Florfenicol [73231-34-2]; Up 200; 11.2uM; HL60; HT_HG-U133A	L3MBTL1 RAP1GAP2 TMOD1 USP6NL BTRC	1.54e-04	196	59	5	3083_UP
Drug	haloperidol; Down 200; 10uM; HL60; HT_HG-U133A	CACTIN L3MBTL1 LPP AFF3 TMOD1	1.54e-04	196	59	5	6203_DN
Drug	Zimelidine dihydrochloride monohydrate [61129-30-4]; Down 200; 9.8uM; MCF7; HT_HG-U133A	TPST1 CACTIN TMOD1 STK24 BTRC	1.54e-04	196	59	5	5670_DN
Drug	Terconazole [67915-31-5]; Up 200; 7.6uM; HL60; HT_HG-U133A	A2M MYO1E TMOD1 YTHDC2 BTRC	1.54e-04	196	59	5	2484_UP
Drug	Indoprofen [31842-01-0]; Up 200; 14.2uM; HL60; HT_HG-U133A	L3MBTL1 RALGAPB EXTL1 BTRC HDGFL3	1.58e-04	197	59	5	3007_UP
Drug	Flurbiprofen [5104-49-4]; Down 200; 16.4uM; PC3; HT_HG-U133A	L3MBTL1 RAB3GAP2 LPP STK24 TLX2	1.58e-04	197	59	5	4674_DN
Drug	Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A	RAP1GAP2 EXTL1 PIAS2 BTRC TLX2	1.58e-04	197	59	5	6180_UP
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	L3MBTL1 AFF2 RAB3GAP2 LPP STK24	1.58e-04	197	59	5	4679_DN
Drug	Hexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; PC3; HT_HG-U133A	APC TMOD1 BTRC PRR7 TLX2	1.58e-04	197	59	5	5768_UP
Drug	Hydroflumethiazide [135-09-1]; Up 200; 12uM; HL60; HT_HG-U133A	CACTIN L3MBTL1 AFF2 APC IQCK	1.62e-04	198	59	5	1851_UP
Drug	fluphenazine dihydrochloride; Up 200; 10uM; HL60; HT_HG-U133A	MRTFB L3MBTL1 MYO1E RALGAPB TMOD1	1.62e-04	198	59	5	1178_UP
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; MCF7; HT_HG-U133A	CACTIN AFF2 YTHDC2 STK24 IQCK	1.62e-04	198	59	5	7544_UP
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A	A2M L3MBTL1 AFF2 RAB3GAP2 APC	1.62e-04	198	59	5	4171_UP
Drug	5149715; Down 200; 10uM; MCF7; HT_HG-U133A_EA	CACTIN LDB1 MYO1E PIAS2 USP6NL	1.62e-04	198	59	5	890_DN
Drug	Hecogenin [467-55-0]; Up 200; 9.2uM; HL60; HT_HG-U133A	CACTIN RIPOR2 APC TMOD1 BTRC	1.62e-04	198	59	5	2716_UP
Drug	dopamine hydrochloride; Up 200; 1uM; MCF7; HG-U133A	CACTIN MYO1E APC GPATCH8 GDF3	1.62e-04	198	59	5	491_UP
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; MCF7; HT_HG-U133A	RIPOR2 L3MBTL1 AFF2 RAB3GAP2 EXTL1	1.62e-04	198	59	5	4751_UP
Drug	Nifurtimox [23256-30-6]; Down 200; 14uM; HL60; HT_HG-U133A	CACTIN MRTFB MYO1E APC HDGFL3	1.66e-04	199	59	5	2908_DN
Drug	Bumetanide [28395-03-1]; Up 200; 11uM; HL60; HT_HG-U133A	L3MBTL1 APC RAP1GAP2 TMOD1 HDGFL3	1.66e-04	199	59	5	2409_UP
Drug	Carbinoxamine maleate salt [3505-38-2]; Down 200; 9.8uM; HL60; HT_HG-U133A	L3MBTL1 APC ATP1B1 USP6NL IQCK	1.66e-04	199	59	5	2725_DN
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; HL60; HT_HG-U133A	RAB3GAP2 LPP AFF3 RAP1GAP2 TMOD1	1.66e-04	199	59	5	2408_UP
Drug	Suloctidil [54063-56-8]; Down 200; 11.8uM; PC3; HT_HG-U133A	L3MBTL1 APC YTHDC2 PCDH1 IQCK	1.66e-04	199	59	5	6675_DN
Disease	electrocardiography	RYBP RIPOR2 SCN5A YTHDC2 ATP1B1 PTK2 SGK3	7.05e-05	530	57	7	EFO_0004327
Disease	neuroticism measurement, wellbeing measurement, depressive symptom measurement	SHISA9 STK24	6.14e-04	19	57	2	EFO_0007006, EFO_0007660, EFO_0007869
Disease	S-7-hydroxywarfarin measurement	AFF3 BTRC SHISA6	1.27e-03	110	57	3	EFO_0803329

Protein segments in the cluster

Peptide	Gene	Start	Entry
NPPNYGKPDPKIIEN	TPST1	331	O60507
PGKVEPTKFPFPNKD	AFF3	321	P51826
FKPKPPKNESLETYP	ATP1B1	186	P05026
ITPPQQPYKKRPKIC	CDK12	691	Q9NYV4
FQQKPPPPPKKIYNY	CLPX	161	O76031
IVNPPPPEYINTKKN	BRDT	11	Q58F21
PNIPLAPEKKKYRGP	AFF2	686	P51816
YLFKNKPPDGNAPPN	BTRC	251	Q9Y297
QPAEEGPSVPKIYKQ	BEND4	6	Q6ZU67
RGVEKNKPVFYPKPP	C7orf31	231	Q8N865
PPLQPKTKTYEEDPK	DHX29	201	Q7Z478
PKTEYGPPRKQPKQQ	CCER1	56	Q8TC90
ENPKNQAPPGLYTKT	ASS1	196	P00966
PQKPKAPVGHFYEPQ	A2M	1186	P01023
PSVPLLGQVKEKPQY	SLC24A4	286	Q8NFF2
QPPFPEGYKVKQEPV	IQCK	66	Q8N0W5
SGNENIQPPPLAYKK	RAB3GAP2	241	Q9H2M9
KLYSPKEPPNGNAFP	LDB1	16	Q86U70
TPKPEPEPEQVIKNY	DTX2	386	Q86UW9
DKAPSPQKFQPVPYI	GDF3	36	Q9NR23
PNKAGPKLKDPPQGY	GPATCH8	1116	Q9UKJ3
CQKQGKPLTPPQDYP	L3MBTL1	471	Q9Y468
PPKYPSKQVGQPFQL	PCDH1	1026	Q08174
QYIPPDQKGEKNEPQ	MRTFB	296	Q9ULH7
QKDPDPEFPTVKYPN	PGM2	281	Q96G03
APVVAPKPKYNPYKQ	LPP	46	Q93052
MSYQKKQPTPQPPVD	LORICRIN	1	P23490
PLYPKNVLENKNSGP	PAXBP1	751	Q9Y5B6
ELPEGAVKPPANKYP	HDGFL3	31	Q9Y3E1
AEKQEQPPPSYKPLF	PRR7	191	Q8TB68
YNISPDPEKQKAPQK	CMYA5	3061	Q8N3K9
YFPKSENQPPKAQPP	BCL9L	1341	Q86UU0
DNPPPKIVQGYKFNI	CACTIN	666	Q8WUQ7
DLVQKKIPPPFNPNV	SGK3	426	Q96BR1
LPGYAPPPKNGIEQK	PIAS2	241	O75928
EKKNKIVYPPQLPGE	MRPL22	46	Q9NWU5
PGPQKNKDDYIPYPS	RAP1GAP2	76	Q684P5
NNPPTLEGNYSKPLK	STK24	246	Q9Y6E0
YQPVGKPDPAAPPKK	PTK2	861	Q05397
VAQQYATPPPPKKEK	RYBP	66	Q8N488
PAQPEFNVYPKKPPQ	PRAM1	216	Q96QH2
KYPADVAANGPPKPL	PKD1L3	96	Q7Z443
PQKPIPRPLNKYQGF	SCN5A	1506	Q14524
PGPENKYDPEKDKTN	SHISA6	161	Q6ZSJ9
SNPYEQQPPGKELNK	SHISA9	261	B4DS77
KLPKNYDPKVTPDPE	SRP72	561	O76094
PIKVPYGKQRQEAAP	EXTL1	601	Q92935
KNNNPPKEPQPKRVE	RIPOR2	61	Q9Y4F9
GKKKAQYEEPQAPPP	SPAG17	401	Q6Q759
APLDNAPKEYPPKIQ	MRPL12	51	P52815
KPTSPVKPIPQNTEY	APC	1771	P25054
GKNPVNSKNLPPEYD	ZNF567	121	Q8N184
KEDEYPKKPLGQLPP	USP6NL	361	Q92738
KPTQYKPVPDEEPNS	TMOD1	166	P28289
SNNRFYPPPPKGKEV	SELENON	236	Q9NZV5
NQKLFVPEPRPVPKN	RALGAPB	1001	Q86X10
GYDPQAKAPFQPKPK	WDR46	541	O15213
QPQYKKIPPANGQAA	YTHDC2	1011	Q9H6S0
GHPYQNRTPPKRKKP	TLX2	146	O43763
PGAYNPEKKPPPKIA	PIFO	131	Q8TCI5
QPKPKPQVPQCKALY	MYO1E	1046	Q12965