Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	KRT6A SPTAN1 KRT20 ACTN4 PLS1	2.90e-05	130	55	5	GO:0005200
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT1 KRT6A KRT76	2.26e-04	43	55	3	GO:0030280
GeneOntologyMolecularFunction	actin filament binding	MYO1C SPTAN1 MACF1 ACTN4 PLS1	3.98e-04	227	55	5	GO:0051015
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT1 KRT6A KRT76 KRT20 MACF1	6.04e-06	99	54	5	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT1 KRT6A KRT76 KRT20 MACF1	6.34e-06	100	54	5	GO:0045103
GeneOntologyBiologicalProcess	intermediate filament organization	KRT1 KRT6A KRT76 KRT20	4.44e-05	75	54	4	GO:0045109
GeneOntologyCellularComponent	supramolecular fiber	KRT1 KRT6A KRT76 MYO1C CFAP77 INPP5D SPTAN1 SCTR KRT20 MACF1 ACTN4 PLS1 DNAH14	8.63e-06	1179	55	13	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	KRT1 KRT6A KRT76 MYO1C CFAP77 INPP5D SPTAN1 SCTR KRT20 MACF1 ACTN4 PLS1 DNAH14	9.28e-06	1187	55	13	GO:0099081
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KRT1 KRT6A KRT76 MYO1C CFAP77 INPP5D SCTR KRT20 MACF1 PLS1 DNAH14	1.85e-05	899	55	11	GO:0099513
GeneOntologyCellularComponent	vesicle lumen	A2M SPTAN1 VPS13A ACTN4 APOB PSMD12	2.31e-04	332	55	6	GO:0031983
GeneOntologyCellularComponent	intermediate filament	KRT1 KRT6A KRT76 KRT20 MACF1	3.23e-04	227	55	5	GO:0005882
GeneOntologyCellularComponent	cortical cytoskeleton	INPP5D SPTAN1 ACTN4 PLS1	3.70e-04	129	55	4	GO:0030863
GeneOntologyCellularComponent	cell cortex	MYO1C INPP5D SPTAN1 MACF1 ACTN4 PLS1	4.18e-04	371	55	6	GO:0005938
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT1 KRT6A KRT76 KRT20 MACF1	6.32e-04	263	55	5	GO:0045111
GeneOntologyCellularComponent	secretory granule lumen	A2M SPTAN1 VPS13A ACTN4 PSMD12	1.62e-03	325	55	5	GO:0034774
GeneOntologyCellularComponent	cytoplasmic vesicle lumen	A2M SPTAN1 VPS13A ACTN4 PSMD12	1.73e-03	330	55	5	GO:0060205
GeneOntologyCellularComponent	cortical actin cytoskeleton	SPTAN1 ACTN4 PLS1	1.89e-03	93	55	3	GO:0030864
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	MYO1C SRCAP HDAC1	2.07e-03	96	55	3	GO:0070603
GeneOntologyCellularComponent	keratin filament	KRT1 KRT6A KRT76	2.13e-03	97	55	3	GO:0045095
GeneOntologyCellularComponent	P-body	SAMD4B UPF1 SAMD4A	2.46e-03	102	55	3	GO:0000932
Domain	-	SAMD4B SAMD4A	8.21e-06	2	54	2	1.25.40.170
Domain	PHAT_dom	SAMD4B SAMD4A	8.21e-06	2	54	2	IPR015327
Domain	Intermediate_filament_CS	KRT1 KRT6A KRT76 KRT20	3.28e-05	63	54	4	IPR018039
Domain	Actinin_actin-bd_CS	MACF1 ACTN4 PLS1	3.88e-05	23	54	3	IPR001589
Domain	Spectrin	SPTAN1 MACF1 ACTN4	3.88e-05	23	54	3	PF00435
Domain	ACTININ_2	MACF1 ACTN4 PLS1	3.88e-05	23	54	3	PS00020
Domain	ACTININ_1	MACF1 ACTN4 PLS1	3.88e-05	23	54	3	PS00019
Domain	Keratin_2_head	KRT1 KRT6A KRT76	4.43e-05	24	54	3	IPR032444
Domain	Keratin_2_head	KRT1 KRT6A KRT76	4.43e-05	24	54	3	PF16208
Domain	Filament	KRT1 KRT6A KRT76 KRT20	5.25e-05	71	54	4	SM01391
Domain	IF	KRT1 KRT6A KRT76 KRT20	5.55e-05	72	54	4	PS00226
Domain	Keratin_II	KRT1 KRT6A KRT76	5.67e-05	26	54	3	IPR003054
Domain	Filament	KRT1 KRT6A KRT76 KRT20	5.86e-05	73	54	4	PF00038
Domain	IF	KRT1 KRT6A KRT76 KRT20	6.86e-05	76	54	4	IPR001664
Domain	Spectrin_repeat	SPTAN1 MACF1 ACTN4	7.92e-05	29	54	3	IPR002017
Domain	Spectrin/alpha-actinin	SPTAN1 MACF1 ACTN4	1.07e-04	32	54	3	IPR018159
Domain	SPEC	SPTAN1 MACF1 ACTN4	1.07e-04	32	54	3	SM00150
Domain	EF-hand_Ca_insen	SPTAN1 ACTN4	1.22e-04	6	54	2	IPR014837
Domain	EFhand_Ca_insen	SPTAN1 ACTN4	1.22e-04	6	54	2	PF08726
Domain	Keratin_I	KRT1 KRT76 KRT20	2.78e-04	44	54	3	IPR002957
Domain	CH	MACF1 ACTN4 PLS1	8.79e-04	65	54	3	SM00033
Domain	EF-hand_1	SPTAN1 MACF1 ACTN4 PLS1	9.72e-04	152	54	4	PF00036
Domain	CH	MACF1 ACTN4 PLS1	1.09e-03	70	54	3	PF00307
Domain	EFh	SPTAN1 MACF1 ACTN4 PLS1	1.12e-03	158	54	4	SM00054
Domain	-	MACF1 ACTN4 PLS1	1.14e-03	71	54	3	1.10.418.10
Domain	CH	MACF1 ACTN4 PLS1	1.23e-03	73	54	3	PS50021
Domain	CH-domain	MACF1 ACTN4 PLS1	1.33e-03	75	54	3	IPR001715
Domain	EF_Hand_1_Ca_BS	SPTAN1 MACF1 ACTN4 PLS1	1.63e-03	175	54	4	IPR018247
Domain	EF-hand_7	SPTAN1 MACF1 PLS1	1.91e-03	85	54	3	PF13499
Domain	HormR	CALCR SCTR	2.36e-03	25	54	2	SM00008
Domain	EF_HAND_1	SPTAN1 MACF1 ACTN4 PLS1	2.85e-03	204	54	4	PS00018
Domain	HRM	CALCR SCTR	2.96e-03	28	54	2	PF02793
Domain	GPCR_2_secretin-like_CS	CALCR SCTR	4.34e-03	34	54	2	IPR017983
Domain	EF_HAND_2	SPTAN1 MACF1 ACTN4 PLS1	4.44e-03	231	54	4	PS50222
Domain	EF_hand_dom	SPTAN1 MACF1 ACTN4 PLS1	4.51e-03	232	54	4	IPR002048
Domain	G_PROTEIN_RECEP_F2_1	CALCR SCTR	5.97e-03	40	54	2	PS00649
Domain	GPCR_2_extracellular_dom	CALCR SCTR	5.97e-03	40	54	2	IPR001879
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT1 KRT6A KRT76 MYO1C KIAA0825 COG1 SACS SPTAN1 CNTRL VPS13A KRT20 MACF1 ABCF2 ACTN4 APOB SRCAP PLS1 CHRNA1 GOLGB1 PHTF1 HDAC1 VDAC3	1.16e-16	1442	55	22	35575683
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	KRT1 KRT6A KRT76 IPO7 MYO1C SPTAN1 CNTRL KRT20 ACTN4 FYCO1 GOLGA4 GOLGB1	6.86e-11	564	55	12	21565611
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	CUL4B MYO1C SPTAN1 MACF1 ABCF2 ACTN4 PSMD12 SRCAP IKBIP GOLGB1 HDAC1 VDAC3	6.76e-09	847	55	12	35235311
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	CUL4B KRT1 KRT6A CHAF1B ABCF2 ACTN4 GOLGA4 HDAC1	2.27e-08	298	55	8	30737378
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	CUL4B KRT1 KRT6A MYO1C HPGD ABCF2 ACTN4 PSMD12 UPF1 ALDH3A2 GOLGA4	4.41e-08	803	55	11	36517590
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	KRT1 MYO1C SPTAN1 MACF1 PSMD12 UPF1 ALDH3A2 GOLGB1 HDAC1 VDAC3	1.53e-07	711	55	10	33022573
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT1 KRT6A KRT76 MYO1C INPP5D SPTAN1 ACTN4	2.10e-07	266	55	7	19380743
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	A2M CHAF1B IPO7 COG1 SPTAN1 CNTRL APOB PSMD12 UPF1 GOLGB1	2.62e-07	754	55	10	35906200
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	A2M IPO7 SPTAN1 ABCF2 ACTN4 PSMD12 UPF1 HDAC1 VDAC3	4.41e-07	607	55	9	39147351
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	MYO1C SPTAN1 CNTRL MACF1 ACTN4 FYCO1 PSMD12 UPF1 SRCAP VDAC3	4.87e-07	807	55	10	30575818
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	A2M KRT1 KRT6A IPO7 MYO1C SPTAN1 ABCF2 ACTN4 UPF1 IKBIP HDAC1 VDAC3	4.91e-07	1257	55	12	36526897
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	KRT1 KRT6A MYO1C SPTAN1 MACF1 ACTN4	5.88e-07	191	55	6	33762435
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	ZNF106 IPO7 MYO1C SPTAN1 MACF1 ACTN4 APOB PSMD12 ALDH3A2 IKBIP HDAC1 VDAC3	6.84e-07	1297	55	12	33545068
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	MYO1C CCDC73 VPS13A FYCO1 GOLGB1 PHTF1	9.67e-07	208	55	6	33230847
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	IPO7 MACF1 ABCF2 PSMD12 UPF1 ALDH3A2 GOLGA4 GOLGB1 HDAC1	1.57e-06	708	55	9	39231216
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	KRT1 KRT6A IPO7 SPTAN1 FNBP4 MACF1 ABCF2 ACTN4 UPF1 GOLGA4 GOLGB1 VDAC3	1.70e-06	1415	55	12	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IPO7 MYO1C SPTAN1 ABCF2 ACTN4 APOB PSMD12 UPF1 ALDH3A2 GOLGA4 HDAC1 VDAC3	1.83e-06	1425	55	12	30948266
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	CUL4B IPO7 MYO1C SPTAN1 MACF1 ACTN4	1.96e-06	235	55	6	28378594
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	KRT1 CHAF1B IPO7 MYO1C COG1 SPTAN1 ABCF2 PSMD12 UPF1 ALDH3A2 SAMD4A VDAC3	2.04e-06	1440	55	12	30833792
Pubmed	Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.	KRT1 SPTAN1 ACTN4	2.07e-06	16	55	3	16944923
Pubmed	Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells.	ABCF2 ACTN4	2.46e-06	2	55	2	22252987
Pubmed	Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery.	MACF1 GOLGA4	2.46e-06	2	55	2	15265687
Pubmed	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	SAMD4B SAMD4A	2.46e-06	2	55	2	16221671
Pubmed	Exome sequencing: an efficient diagnostic tool for complex neurodegenerative disorders.	SACS APOB	2.46e-06	2	55	2	23043354
Pubmed	New consensus nomenclature for mammalian keratins.	KRT1 KRT6A KRT76 KRT20	3.11e-06	63	55	4	16831889
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	IPO7 MYO1C SPTAN1 ACTN4	3.11e-06	63	55	4	37052853
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CUL4B ZNF106 CHAF1B MYO1C SPTAN1 SAMD4B FNBP4 TACC3 GOLGA4	3.25e-06	774	55	9	15302935
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	CUL4B KRT1 KRT6A MYO1C SPTAN1 ACTN4 UPF1 GOLGB1	3.48e-06	580	55	8	35676659
Pubmed	RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.	KRT1 KRT6A ABCF2 PSMD12 HDAC1	3.58e-06	146	55	5	21589869
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	KRT6A CHAF1B IPO7 SACS MACF1 ABCF2 ACTN4 SRCAP GOLGB1 VDAC3	4.12e-06	1024	55	10	24711643
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CUL4B IPO7 SPTAN1 ACTN4 PSMD12 UPF1 ALDH3A2 HDAC1	6.99e-06	638	55	8	33239621
Pubmed	Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.	KRT6A KRT20	7.36e-06	3	55	2	33086575
Pubmed	Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin.	KRT1 KRT6A	7.36e-06	3	55	2	1713533
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	A2M KRT1 CHAF1B SPTAN1 ACTN4 APOB HDAC1 VDAC3	8.19e-06	652	55	8	31180492
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CUL4B IPO7 MYO1C SPTAN1 MACF1 ACTN4 PSMD12 UPF1	8.28e-06	653	55	8	22586326
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	KRT6A MYO1C SPTAN1 MACF1 ACTN4 UPF1 PLS1 HDAC1	8.95e-06	660	55	8	32780723
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	IPO7 ABCF2 ACTN4 UPF1 GOLGB1	9.64e-06	179	55	5	36261009
Pubmed	A human MAP kinase interactome.	ZNF106 SPTAN1 CNTRL KRT20 MACF1 ACTN4 GOLGB1	1.13e-05	486	55	7	20936779
Pubmed	E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.	MYO1C INPP5D UPF1	1.19e-05	28	55	3	30277474
Pubmed	Defining the membrane proteome of NK cells.	KRT1 KRT6A IPO7 MYO1C CNTRL ABCF2 FYCO1 PSMD12 IKBIP GOLGB1	1.30e-05	1168	55	10	19946888
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	MYO1C SPTAN1 FNBP4 ACTN4 SRCAP PLS1 GOLGB1	1.47e-05	506	55	7	30890647
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	KRT1 IPO7 MYO1C SPTAN1 ABCF2 ACTN4 APOB UPF1 HDAC1	1.67e-05	949	55	9	36574265
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	IPO7 SACS SPTAN1 VPS13A FNBP4 MACF1 UPF1 ALDH3A2 IKBIP GOLGA4 GOLGB1	1.78e-05	1487	55	11	33957083
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	KRT1 MACF1 GOLGB1	2.16e-05	34	55	3	25925205
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	KRT6A MYO1C SPTAN1 MACF1 GOLGA4 GOLGB1	2.23e-05	360	55	6	33111431
Pubmed	Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.	TACC3 IKBIP GOLGB1	2.36e-05	35	55	3	27812135
Pubmed	A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery.	MACF1 GOLGA4	2.45e-05	5	55	2	22705394
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	KRT6A MYO1C SPTAN1 IKBIP GOLGA4	2.72e-05	222	55	5	35941108
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	KRT1 MYO1C CNTRL VPS13A APOB TACC3 GOLGA4 GOLGB1	2.88e-05	777	55	8	35844135
Pubmed	ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.	KRT1 KRT6A KRT76 CNTRL	3.17e-05	113	55	4	34474245
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPN9 IPO7 MYO1C SPTAN1 VPS13A ACTN4 PSMD12 ALDH3A2 GOLGA4	3.65e-05	1049	55	9	27880917
Pubmed	Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.	SPTAN1 ACTN4	3.67e-05	6	55	2	35602553
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	IPO7 MYO1C SPTAN1 ACTN4	3.76e-05	118	55	4	27377895
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	MYO1C SPTAN1 IKBIP GOLGB1	3.76e-05	118	55	4	30979931
Pubmed	An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry.	ZNF106 MYO1C ACTN4	4.42e-05	43	55	3	30975701
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	KRT1 KRT6A SACS SPTAN1 FNBP4 MACF1 UPF1 SRCAP VDAC3	4.64e-05	1082	55	9	38697112
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	CUL4B PSMD12 UPF1 ALDH3A2 HDAC1	5.06e-05	253	55	5	29911972
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	MYO1C ACTN4 PLS1	5.07e-05	45	55	3	22114352
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	A2M KRT1 KRT6A IPO7 SPTAN1 FNBP4 APOB UPF1 IKBIP VDAC3	5.09e-05	1371	55	10	36244648
Pubmed	Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2.	SPTAN1 CHRNA1	5.13e-05	7	55	2	1315305
Pubmed	Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B.	CALCR APOB	5.13e-05	7	55	2	12397072
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	KRT1 MYO1C SPTAN1 ABCF2 ACTN4 UPF1 HDAC1	5.68e-05	626	55	7	33644029
Pubmed	An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.	MYO1C SPTAN1 HDAC1	6.15e-05	48	55	3	17620012
Pubmed	Identification of DeltaNp63alpha protein interactions by mass spectrometry.	A2M SACS GOLGA4	6.15e-05	48	55	3	20085233
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	A2M MYO1C ACTN4	6.55e-05	49	55	3	21362503
Pubmed	TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi.	TBC1D23 GOLGA4	6.83e-05	8	55	2	29084197
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	A2M IPO7 MYO1C SPTAN1 ACTN4 PSMD12 UPF1	6.98e-05	647	55	7	26618866
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	KRT1 KRT6A KRT76 MYO1C SACS SPTAN1 MACF1 ACTN4 UPF1 VDAC3	7.27e-05	1431	55	10	37142655
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	IPO7 TMEM9 COG1 PSMD12 ALDH3A2 GOLGB1	7.60e-05	449	55	6	31732153
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	IPO7 MYO1C ABCF2 PSMD12 UPF1 HDAC1 VDAC3	8.29e-05	665	55	7	30457570
Pubmed	CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.	CUL4B KRT1 HDAC1	8.29e-05	53	55	3	34026424
Pubmed	CIN85 interacting proteins in B cells-specific role for SHIP-1.	INPP5D SPTAN1 ACTN4	8.77e-05	54	55	3	21725061
Pubmed	A mutant mouse with severe anemia and skin abnormalities controlled by a new allele of the flaky skin (fsn) locus.	KRT1 KRT6A	8.78e-05	9	55	2	16093647
Pubmed	Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.	KRT6A KRT76	8.78e-05	9	55	2	15737194
Pubmed	RIP4 regulates epidermal differentiation and cutaneous inflammation.	KRT1 KRT6A	8.78e-05	9	55	2	19626033
Pubmed	Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).	CUL4B CHAF1B HDAC1	9.26e-05	55	55	3	27114453
Pubmed	CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.	KRT6A KRT76 IPO7 MYO1C SPTAN1	9.32e-05	288	55	5	31501420
Pubmed	Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.	A2M KRT1 KRT6A MYO1C ACTN4	9.48e-05	289	55	5	37132043
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	IPO7 MYO1C SPTAN1 CNTRL ACTN4 PSMD12	9.54e-05	468	55	6	36042349
Pubmed	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.	KRT1 KRT6A KRT76	1.03e-04	57	55	3	31862882
Pubmed	USP7 controls NGN3 stability and pancreatic endocrine lineage development.	MYO1C SPTAN1 MACF1	1.09e-04	58	55	3	37117185
Pubmed	Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.	MACF1 CHRNA1	1.10e-04	10	55	2	33773096
Pubmed	Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.	CALCR SCTR	1.10e-04	10	55	2	15670850
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	IPO7 SPTAN1 ACTN4 UPF1 GOLGB1 VDAC3	1.15e-04	484	55	6	31995728
Pubmed	TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.	KRT1 KRT6A MYO1C SPTAN1 ACTN4	1.22e-04	305	55	5	33194618
Pubmed	An investigation into the human serum "interactome".	KRT1 KRT6A SACS MACF1	1.29e-04	162	55	4	15174051
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PTPN9 SPTAN1 MACF1 FYCO1 UPF1 TACC3 GOLGA4 GOLGB1	1.29e-04	963	55	8	28671696
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	CUL4B SPTAN1 ACTN4 PSMD12 TACC3 HDAC1	1.30e-04	495	55	6	28581483
Pubmed	RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma.	MYO1C SPTAN1 ACTN4	1.32e-04	62	55	3	35568845
Pubmed	CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression.	CUL4B HDAC1	1.34e-04	11	55	2	25189618
Pubmed	A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.	SAMD4B SAMD4A	1.34e-04	11	55	2	26609159
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	KRT1 MYO1C ABCF2 ACTN4 UPF1	1.36e-04	312	55	5	37120454
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	A2M APOB GOLGA4 GOLGB1	1.38e-04	165	55	4	14718574
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	A2M PTPN9 IPO7 ABCF2 ACTN4 PSMD12 ALDH3A2 PLS1	1.39e-04	974	55	8	28675297
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	MYO1C SPTAN1 ACTN4 FYCO1 IKBIP VDAC3	1.41e-04	503	55	6	36217030
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	KRT1 CHAF1B IPO7 ABCF2 UPF1 ALDH3A2 HDAC1	1.41e-04	725	55	7	27025967
Pubmed	K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.	CUL4B IPO7 HDAC1	1.52e-04	65	55	3	29378950
Pubmed	A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland.	APOB CHRNA1	1.60e-04	12	55	2	8631881
Pubmed	VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.	KRT1 KRT6A IPO7 KRT20 ALDH3A2	1.73e-04	329	55	5	35562734
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	SACS SPTAN1 MACF1 ACTN4 TACC3	1.81e-04	332	55	5	37433992
Interaction	KCNA3 interactions	IPO7 MYO1C CCDC73 VPS13A MACF1 ABCF2 FYCO1 PSMD12 UPF1 ALDH3A2 GOLGA4 GOLGB1 PHTF1 HDAC1	5.96e-08	871	55	14	int:KCNA3
Interaction	PRPH interactions	CUL4B KRT1 KRT6A KRT76 SACS KRT20 PSMD12	1.32e-06	204	55	7	int:PRPH
Interaction	KRT7 interactions	KRT1 KRT6A KRT76 KRT20 GOLGA4	2.59e-06	80	55	5	int:KRT7
Interaction	KRT76 interactions	CUL4B KRT6A KRT76 KRT20 PHTF1	3.29e-06	84	55	5	int:KRT76
Interaction	NPHP4 interactions	KRT1 KRT6A MYO1C SPTAN1 CNTRL KRT20 GOLGB1	3.48e-06	236	55	7	int:NPHP4
Interaction	UBASH3B interactions	KRT1 KRT6A INPP5D SPTAN1 ACTN4 HDAC1	4.30e-06	157	55	6	int:UBASH3B
Interaction	ACE2 interactions	CUL4B KRT1 MYO1C SPTAN1 ABCF2 ACTN4 PSMD12 UPF1 TACC3 PLS1 GOLGA4 GOLGB1 VDAC3	6.41e-06	1106	55	13	int:ACE2
Interaction	VIM interactions	CUL4B KRT1 KRT6A KRT76 SACS SPTAN1 CNTRL KRT20 PSMD12 GOLGA4 HDAC1	9.13e-06	804	55	11	int:VIM
Interaction	KRT84 interactions	KRT6A KRT76 KRT20 PHTF1	9.60e-06	49	55	4	int:KRT84
Interaction	KRT75 interactions	CUL4B KRT1 KRT6A KRT76 KRT20 PHTF1	9.72e-06	181	55	6	int:KRT75
Interaction	KRT5 interactions	CUL4B KRT1 KRT6A KRT76 KRT20 PHTF1	1.40e-05	193	55	6	int:KRT5
Interaction	KRT13 interactions	CUL4B KRT1 KRT6A KRT76 KRT20	1.60e-05	116	55	5	int:KRT13
Interaction	SOX2 interactions	CUL4B A2M TPMT CHAF1B IPO7 MYO1C SPTAN1 SAMD4B MACF1 ACTN4 PSMD12 UPF1 PLS1 HDAC1	1.99e-05	1422	55	14	int:SOX2
Interaction	FGD5 interactions	KRT1 KRT6A MYO1C SPTAN1 MACF1 ACTN4	2.08e-05	207	55	6	int:FGD5
Interaction	PHTF1 interactions	KRT6A KRT76 PHTF1	2.12e-05	20	55	3	int:PHTF1
Interaction	GJA1 interactions	A2M COG1 SPTAN1 VPS13A MACF1 APOB ALDH3A2 GOLGA4 GOLGB1	2.59e-05	583	55	9	int:GJA1
Interaction	GOLGA4 interactions	KRT6A MACF1 PSMD12 GOLGA4 GOLGB1 HDAC1	3.41e-05	226	55	6	int:GOLGA4
Interaction	PCNT interactions	IPO7 SPTAN1 CNTRL MACF1 IKBIP HDAC1	4.88e-05	241	55	6	int:PCNT
Interaction	SHC1 interactions	KRT1 KRT6A IPO7 MYO1C INPP5D SPTAN1 ACTN4	5.51e-05	362	55	7	int:SHC1
Interaction	ATG16L1 interactions	TRAF7 IPO7 INPP5D CNTRL FNBP4 ABCF2 ACTN4 TBC1D23 PLS1 IKBIP GOLGB1 HDAC1	5.51e-05	1161	55	12	int:ATG16L1
Interaction	IQCB1 interactions	KRT1 KRT6A IPO7 MYO1C SPTAN1 ACTN4 FYCO1	6.32e-05	370	55	7	int:IQCB1
Interaction	CCDC8 interactions	KRT6A CHAF1B IPO7 SACS MACF1 ABCF2 ACTN4 APOB GOLGB1	6.47e-05	656	55	9	int:CCDC8
Interaction	FURIN interactions	CHAF1B MYO1C SPTAN1 ACTN4 GOLGA4 GOLGB1	6.67e-05	255	55	6	int:FURIN
Interaction	DES interactions	KRT1 KRT6A KRT76 SPTAN1 KRT20	7.05e-05	158	55	5	int:DES
Interaction	IFITM3 interactions	MYO1C SPTAN1 ACTN4 FYCO1 ALDH3A2 GOLGA4 GOLGB1 VDAC3	7.10e-05	513	55	8	int:IFITM3
Interaction	CFAP157 interactions	CUL4B GOLGB1	7.27e-05	5	55	2	int:CFAP157
Interaction	KRT28 interactions	KRT1 KRT6A KRT76	7.41e-05	30	55	3	int:KRT28
Interaction	KRT6A interactions	KRT6A KRT76 KRT20 GOLGA4 PHTF1	7.48e-05	160	55	5	int:KRT6A
Interaction	TMOD1 interactions	MYO1C SPTAN1 MACF1 GOLGA4 GOLGB1	7.71e-05	161	55	5	int:TMOD1
Interaction	RAC2 interactions	TRAF7 MYO1C TMEM9 SPTAN1 VPS13A MACF1 ALDH3A2 GOLGA4 GOLGB1	7.96e-05	674	55	9	int:RAC2
Interaction	TNIP1 interactions	KRT1 IPO7 MYO1C SPTAN1 ABCF2 ACTN4 APOB UPF1 PLS1 IKBIP HDAC1 SAMD4A	8.68e-05	1217	55	12	int:TNIP1
Interaction	EED interactions	CUL4B KRT1 KRT6A IPO7 MYO1C SPTAN1 MACF1 ABCF2 ACTN4 PSMD12 UPF1 HDAC1 VDAC3	1.06e-04	1445	55	13	int:EED
Interaction	KRT26 interactions	KRT1 KRT6A KRT76	1.18e-04	35	55	3	int:KRT26
Interaction	KRT25 interactions	KRT1 KRT6A KRT76	1.18e-04	35	55	3	int:KRT25
Interaction	KRT15 interactions	KRT1 KRT6A KRT76 KRT20 IKBIP	1.24e-04	178	55	5	int:KRT15
Interaction	ACTB interactions	CUL4B A2M MYO1C SPTAN1 VPS13A MACF1 ACTN4 SRCAP PLS1 HDAC1 VDAC3	1.39e-04	1083	55	11	int:ACTB
Interaction	GOLGA1 interactions	COG1 MACF1 TBC1D23 GOLGA4 GOLGB1	1.41e-04	183	55	5	int:GOLGA1
Interaction	C2orf69 interactions	TACC3 HDAC1	1.52e-04	7	55	2	int:C2orf69
Interaction	CCSAP interactions	CCDC73 HDAC1	1.52e-04	7	55	2	int:CCSAP
Interaction	IFITM5 interactions	APOB IKBIP	1.52e-04	7	55	2	int:IFITM5
Interaction	WDR5 interactions	CUL4B KRT1 MYO1C SPTAN1 MACF1 PSMD12 UPF1 ALDH3A2 GOLGB1 HDAC1 VDAC3	1.60e-04	1101	55	11	int:WDR5
Interaction	CAPZA2 interactions	ZNF106 IPO7 MYO1C SPTAN1 MACF1 ACTN4 ALDH3A2	1.61e-04	430	55	7	int:CAPZA2
Interaction	DBR1 interactions	SPTAN1 VPS13A APOB	1.77e-04	40	55	3	int:DBR1
Interaction	RND2 interactions	IPO7 SPTAN1 VPS13A PSMD12 ALDH3A2 GOLGA4 GOLGB1	1.85e-04	440	55	7	int:RND2
Interaction	SAFB2 interactions	CUL4B IPO7 MYO1C PSMD12 SRCAP	1.89e-04	195	55	5	int:SAFB2
Interaction	AGR2 interactions	MYO1C SPTAN1 CNTRL MACF1 ACTN4 FYCO1 PSMD12 UPF1 SRCAP VDAC3	1.91e-04	934	55	10	int:AGR2
Interaction	BIRC3 interactions	IPO7 MYO1C SPTAN1 ABCF2 ACTN4 APOB PSMD12 UPF1 ALDH3A2 GOLGA4 HDAC1 VDAC3	2.06e-04	1334	55	12	int:BIRC3
Interaction	STX6 interactions	PTPN9 TMEM9 SPTAN1 MACF1 ALDH3A2 GOLGA4 GOLGB1	2.07e-04	448	55	7	int:STX6
Interaction	DPP4 interactions	KRT1 MYO1C SPTAN1 ACTN4 APOB GOLGB1 VDAC3	2.21e-04	453	55	7	int:DPP4
Interaction	SYVN1 interactions	IPO7 MYO1C TMEM9 APOB ALDH3A2 CHRNA1	2.46e-04	324	55	6	int:SYVN1
Interaction	MSN interactions	SPTAN1 CNTRL PSMD12 SRCAP PLS1 GOLGB1	2.72e-04	330	55	6	int:MSN
Interaction	TES interactions	CUL4B IPO7 MYO1C SPTAN1 MACF1 ACTN4	2.81e-04	332	55	6	int:TES
Interaction	INPPL1 interactions	KRT1 INPP5D SAMD4B ACTN4 SAMD4A	2.91e-04	214	55	5	int:INPPL1
Interaction	SKIL interactions	ZNF106 MACF1 GOLGB1 HDAC1	3.12e-04	119	55	4	int:SKIL
Interaction	CDK2AP2 interactions	A2M KIAA0825 HDAC1	3.24e-04	49	55	3	int:CDK2AP2
Interaction	RNF138 interactions	KRT6A SPTAN1 UPF1 HDAC1	3.77e-04	125	55	4	int:RNF138
Interaction	CLEC4E interactions	MYO1C TMEM9 SPTAN1 ACTN4 GOLGB1 VDAC3	3.89e-04	353	55	6	int:CLEC4E
Interaction	IFITM1 interactions	MYO1C ACTN4 FYCO1 APOB GOLGA4 GOLGB1	4.01e-04	355	55	6	int:IFITM1
Interaction	TPTE interactions	IPO7 PSMD12 ALDH3A2 VDAC3	4.24e-04	129	55	4	int:TPTE
Interaction	TMT1A interactions	PTPN9 TMEM9 VPS13A ALDH3A2 GOLGA4 GOLGB1	4.26e-04	359	55	6	int:TMT1A
Interaction	KRT24 interactions	CUL4B KRT1 KRT20	4.32e-04	54	55	3	int:KRT24
Interaction	RHOF interactions	IPO7 MYO1C SPTAN1 VPS13A MACF1 ACTN4 ALDH3A2 GOLGB1	4.51e-04	673	55	8	int:RHOF
Interaction	KRT2 interactions	CUL4B KRT1 KRT6A KRT20 PHTF1	4.56e-04	236	55	5	int:KRT2
Interaction	ELOVL5 interactions	TMEM9 COG1 VPS13A ALDH3A2 GOLGA4 GOLGB1	4.58e-04	364	55	6	int:ELOVL5
Interaction	RHOH interactions	MYO1C SPTAN1 VPS13A PSMD12 ALDH3A2 GOLGA4 GOLGB1	4.63e-04	512	55	7	int:RHOH
Interaction	MAPRE1 interactions	SPTAN1 MACF1 ACTN4 PSMD12 TACC3 ALDH3A2 VDAC3	4.74e-04	514	55	7	int:MAPRE1
Interaction	CBL interactions	KRT1 KRT6A MYO1C INPP5D SPTAN1 ALDH3A2 PLS1	4.85e-04	516	55	7	int:CBL
Interaction	CTSL interactions	MYO1C SPTAN1 ACTN4 APOB VDAC3	4.92e-04	240	55	5	int:CTSL
Interaction	KIF20A interactions	ZNF106 CHAF1B MYO1C COG1 SPTAN1 MACF1 ACTN4 APOB HDAC1 VDAC3	4.93e-04	1052	55	10	int:KIF20A
Interaction	NUPR1 interactions	KRT6A MYO1C SPTAN1 MACF1 ACTN4 UPF1 PLS1 HDAC1	4.98e-04	683	55	8	int:NUPR1
Interaction	ACTA1 interactions	MYO1C SPTAN1 MACF1 ACTN4 PSMD12 HDAC1	5.06e-04	371	55	6	int:ACTA1
Interaction	LRRC7 interactions	MACF1 ABCF2 ACTN4	5.34e-04	58	55	3	int:LRRC7
Interaction	DCAF4 interactions	CUL4B IPO7 SAMD4B UPF1 GOLGB1 SAMD4A	5.59e-04	378	55	6	int:DCAF4
Interaction	CALCR interactions	CALCR APOB	5.60e-04	13	55	2	int:CALCR
Interaction	KRT72 interactions	KRT6A KRT20 FYCO1	5.61e-04	59	55	3	int:KRT72
Interaction	ECT2 interactions	IPO7 MYO1C SPTAN1 MACF1 ACTN4 UPF1 ALDH3A2 PLS1 VDAC3	6.12e-04	887	55	9	int:ECT2
Interaction	EXOC1 interactions	SPTAN1 MACF1 IKBIP GOLGA4	6.26e-04	143	55	4	int:EXOC1
Interaction	DNAJA2 interactions	TRAF7 SACS SAMD4B ABCF2 UPF1 ALDH3A2 HDAC1	6.50e-04	542	55	7	int:DNAJA2
Interaction	CTSS interactions	MYO1C SPTAN1 ACTN4 IKBIP	6.60e-04	145	55	4	int:CTSS
Interaction	ALB interactions	KRT1 KRT6A MYO1C SACS SPTAN1 APOB	6.67e-04	391	55	6	int:ALB
Interaction	YAP1 interactions	KRT1 KRT6A KRT76 IPO7 MYO1C SPTAN1 FNBP4 UPF1 SRCAP HDAC1	6.73e-04	1095	55	10	int:YAP1
Interaction	SNAI1 interactions	CUL4B IPO7 SPTAN1 ABCF2 UPF1 HDAC1 VDAC3	6.78e-04	546	55	7	int:SNAI1
Interaction	PIM3 interactions	MYO1C SPTAN1 ACTN4	6.80e-04	63	55	3	int:PIM3
Interaction	KRT20 interactions	KRT6A KRT76 KRT20	6.80e-04	63	55	3	int:KRT20
Interaction	COPS5 interactions	CUL4B KRT1 KRT6A KRT76 SPTAN1 ABCF2 PSMD12 UPF1 ALDH3A2 HDAC1	7.08e-04	1102	55	10	int:COPS5
Interaction	LAMTOR1 interactions	PTPN9 MYO1C FYCO1 PSMD12 TBC1D23 ALDH3A2 GOLGA4 GOLGB1	7.17e-04	722	55	8	int:LAMTOR1
Interaction	CLEC4D interactions	MYO1C SPTAN1 ACTN4 GOLGB1 VDAC3	7.19e-04	261	55	5	int:CLEC4D
Interaction	BAP1 interactions	CUL4B KRT1 IPO7 SPTAN1 MACF1 ACTN4 PSMD12 UPF1 IKBIP GOLGA4 HDAC1	7.27e-04	1314	55	11	int:BAP1
Interaction	NEUROG3 interactions	MYO1C SPTAN1 MACF1 SRCAP	7.30e-04	149	55	4	int:NEUROG3
Interaction	EZR interactions	SPTAN1 MACF1 ABCF2 ACTN4 PLS1 GOLGB1 HDAC1	7.31e-04	553	55	7	int:EZR
Interaction	DIRAS3 interactions	TC2N IPO7 SPTAN1 MACF1 GOLGA4	7.32e-04	262	55	5	int:DIRAS3
Interaction	CHMP4B interactions	IPO7 MYO1C SPTAN1 ACTN4 UPF1 TBC1D23 GOLGB1 PMFBP1	7.50e-04	727	55	8	int:CHMP4B
Interaction	HDAC6 interactions	CUL4B KRT1 KRT6A IPO7 MYO1C SPTAN1 ACTN4 UPF1 GOLGB1	8.51e-04	929	55	9	int:HDAC6
Interaction	APOB interactions	CALCR SPTAN1 VPS13A APOB	8.67e-04	156	55	4	int:APOB
Interaction	SIRT7 interactions	CUL4B IPO7 MYO1C SPTAN1 MACF1 ACTN4 PSMD12 UPF1	8.71e-04	744	55	8	int:SIRT7
Interaction	NUP62 interactions	KRT1 KRT6A KRT20 TACC3 IKBIP	8.80e-04	273	55	5	int:NUP62
Interaction	RHOD interactions	MYO1C SPTAN1 VPS13A MACF1 ALDH3A2 GOLGA4 GOLGB1	8.91e-04	572	55	7	int:RHOD
Interaction	RAB35 interactions	MYO1C SPTAN1 CNTRL VPS13A MACF1 ALDH3A2 GOLGB1	9.00e-04	573	55	7	int:RAB35
Interaction	ESCO2 interactions	CUL4B IKBIP HDAC1	9.25e-04	70	55	3	int:ESCO2
Interaction	FAM8A1 interactions	TMEM9 CHRNA1 VDAC3	9.25e-04	70	55	3	int:FAM8A1
Cytoband	12q13.13	KRT1 KRT6A KRT76	7.38e-05	67	55	3	12q13.13
GeneFamily	Keratins, type II	KRT1 KRT6A KRT76	2.42e-05	27	38	3	609
GeneFamily	EF-hand domain containing	SPTAN1 MACF1 PLS1	1.08e-02	219	38	3	863
GeneFamily	Sterile alpha motif domain containing	SAMD4B SAMD4A	1.47e-02	88	38	2	760
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 HPGD CNTRL APOB GOLGB1 HDAC1	1.32e-07	191	55	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 HPGD CNTRL APOB GOLGA4 HDAC1	1.32e-07	191	55	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 HPGD CNTRL APOB GOLGB1 HDAC1	1.32e-07	191	55	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	ZNF106 HPGD CNTRL PSMD12 GOLGA4 GOLGB1	1.63e-07	198	55	6	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M TC2N VPS13A MACF1 GOLGA4 GOLGB1	1.68e-07	199	55	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M TC2N HPGD MACF1 GOLGA4 GOLGB1	1.68e-07	199	55	6	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	ileum\|World / shred on tissue and cell subclass	HPGD KRT20 APOB PLS1 GOLGA4	2.17e-06	170	55	5	9f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HPGD SPTAN1 MACF1 GOLGA4 GOLGB1	3.73e-06	190	55	5	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M TC2N HPGD MACF1 ACTN4	3.93e-06	192	55	5	ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M TC2N HPGD MACF1 ACTN4	3.93e-06	192	55	5	58a7829b411b02b422ef75e2277a868969cc23e8
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Stem_cells\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CHAF1B MYO1C CCDC73 TACC3 CHRNA1	4.03e-06	193	55	5	3091090abcf18b48eac7e6c85653c18aa54fcb9b
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Stem_cells-Stem_cells\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CHAF1B MYO1C CCDC73 TACC3 CHRNA1	4.03e-06	193	55	5	a18770ceb770aaa4903dd04442ad0a73159ead9a
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	HPGD CNTRL PSMD12 GOLGA4 GOLGB1	4.68e-06	199	55	5	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	facs-Marrow-B-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT20 CPED1 PLS1 IKBIP	6.04e-05	172	55	4	a7fd4d61fb5017dce001d69d6b9a01e6cdf58828
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HPGD KRT20 APOB PLS1	6.32e-05	174	55	4	2fbdb62e269acf4447b171700a615e878dde7f9f
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HPGD KRT20 APOB PLS1	6.32e-05	174	55	4	7c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 IPO7 MACF1 CPED1	6.60e-05	176	55	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TC2N MACF1 UPF1 GOLGB1	7.05e-05	179	55	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	TC2N SPTAN1 VPS13A MACF1	7.36e-05	181	55	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 CNTRL MACF1 GOLGA4	7.85e-05	184	55	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TC2N SCTR PLS1 DNAH14	8.18e-05	186	55	4	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNBP4 ABCF2 GOLGA4 GOLGB1	9.06e-05	191	55	4	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M TC2N SPTAN1 VPS13A	9.06e-05	191	55	4	4a29b7d5cd10e9077699d3aa76e3db6c4d5a0cf6
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M TC2N VPS13A MACF1	9.43e-05	193	55	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	T_cells-GZMK+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	A2M TC2N INPP5D ACTN4	9.82e-05	195	55	4	003ea7ddec6c1c98d2f6470bb51ebd97450eb936
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13A MACF1 GOLGA4 GOLGB1	9.82e-05	195	55	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13A MACF1 GOLGA4 GOLGB1	9.82e-05	195	55	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CALCR IPO7 ACTN4 CHRNA1	1.02e-04	197	55	4	5bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TC2N VPS13A MACF1 GOLGA4	1.02e-04	197	55	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	INPP5D SPTAN1 ACTN4 HDAC1	1.02e-04	197	55	4	7c9df6025b9d168bd6d041c6cff1e87e08b11847
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT6A TC2N SPTAN1 ACTN4	1.02e-04	197	55	4	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HPGD KRT20 APOB PLS1	1.04e-04	198	55	4	e3e2233c796d5e9051c8c1b66f70f406f048ed56
ToppCell	Sepsis-URO-Lymphocyte-T/NK-MAIT\|URO / Disease, condition lineage and cell class	TC2N CSMD3 PLS1 DNAH14	1.04e-04	198	55	4	75db638278d4be2b0f406cd8871058a8352c5a86
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HPGD KRT20 APOB PLS1	1.04e-04	198	55	4	2967fb2d94662997bfe932ac299c80d6f182fb48
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HPGD KRT20 APOB PLS1	1.04e-04	198	55	4	8fac96132663f54566136ef54b53684d31dfde32
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HPGD KRT20 APOB PLS1	1.04e-04	198	55	4	222a060c2c63d30da34e4b71c37aa27a048d7d09
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HPGD KRT20 APOB PLS1	1.04e-04	198	55	4	c48b3f026b16d48b8eca9f74dc1e3f3f39a89322
ToppCell	(00)_Basal-(2)_GFP_FOXI1\|(00)_Basal / shred by cell type by condition	HPGD PSMD12 GOLGA4 GOLGB1	1.06e-04	199	55	4	19674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	HPGD ALDH3A2 GOLGA4 GOLGB1	1.06e-04	199	55	4	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	HPGD PSMD12 GOLGA4 GOLGB1	1.06e-04	199	55	4	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	VE-CD4-exh_CD4\|VE / Condition, Cell_class and T cell subcluster	TC2N SPTAN1 MACF1 ACTN4	1.06e-04	199	55	4	6b00a393ad06ae91bf135a54a53ad4de68956193
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HPGD KRT20 APOB PLS1	1.06e-04	199	55	4	0181c13379f869be47804cdb11bbdabcd30b9b23
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	ZNF106 HPGD GOLGA4 GOLGB1	1.06e-04	199	55	4	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	HPGD PSMD12 GOLGA4 GOLGB1	1.06e-04	199	55	4	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-gd_T\|COVID-19_Mild / Disease, condition lineage and cell class	A2M TC2N HPGD MACF1	1.08e-04	200	55	4	6560753d3df2f87860b52052d4881aa45410f666
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M TC2N MACF1 GOLGA4	1.08e-04	200	55	4	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-CD4+_CTL\|ICU-NoSEP / Disease, condition lineage and cell class	TC2N HPGD SPTAN1 MACF1	1.08e-04	200	55	4	c470520ce77130811fdc2a1d3d796d8836275de1
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M TC2N MACF1 GOLGA4	1.08e-04	200	55	4	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	KIAA0825 HPGD SPTAN1 MACF1	1.08e-04	200	55	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
Computational	Actin cytoskeleton binding.	SPTAN1 MACF1 ACTN4	1.68e-04	30	39	3	MODULE_524
Computational	Genes in the cancer module 419.	SPTAN1 MACF1 ACTN4	2.44e-04	34	39	3	MODULE_419
Computational	Genes in the cancer module 153.	KRT1 KRT6A ALDH3A2	2.44e-04	34	39	3	MODULE_153
Computational	Genes upregulated in subsets of cells of a given type within various tumors	MACF1 GOLGA4 GOLGB1	7.25e-04	49	39	3	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Computational	Genes upregulated in subsets of cells of a given type within various tumors	HPGD KRT20 APOB	7.69e-04	50	39	3	GAVISH_3CA_METAPROGRAM_EPITHELIAL_PDAC_RELATED_3
Computational	Genes upregulated in subsets of cells of a given type within various tumors	MACF1 GOLGA4 GOLGB1	7.69e-04	50	39	3	GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	ZNF106 APOB PMFBP1	2.04e-04	61	55	3	EFO_0008317, EFO_0008596, EFO_0020946
Disease	inflammatory bowel disease (is_marker_for)	TPMT HPGD	2.22e-04	12	55	2	DOID:0050589 (is_marker_for)
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 MACF1 APOB	2.70e-04	67	55	3	EFO_0008595, EFO_0020946
Disease	amenorrhea, response to antineoplastic agent	CALCR APOB	3.53e-04	15	55	2	EFO_0010269, GO_0097327
Disease	cerebral infarction (is_marker_for)	A2M APOB	5.72e-04	19	55	2	DOID:3526 (is_marker_for)
Disease	nephrotic syndrome (biomarker_via_orthology)	A2M APOB	9.17e-04	24	55	2	DOID:1184 (biomarker_via_orthology)
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 MACF1 APOB	9.50e-04	103	55	3	EFO_0008595, EFO_0020944
Disease	von Willebrand factor measurement, coronary artery disease	TC2N APOB PMFBP1	1.41e-03	118	55	3	EFO_0001645, EFO_0004629
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 MACF1 APOB	1.51e-03	121	55	3	EFO_0008595, EFO_0020943
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 MACF1 APOB	1.73e-03	127	55	3	EFO_0008595, EFO_0020947
Disease	sphingomyelin measurement	KRT1 KRT6A APOB UPF1	1.80e-03	278	55	4	EFO_0010118

Protein segments in the cluster

Peptide	Gene	Start	Entry
QKVNEKIETSINLAW	VDAC3	196	Q9Y277
IQQVAQEIWVCEKQT	ABCF2	576	Q9UG63
ISQQQKGEIEWQKQL	CNTRL	1746	Q7Z7A1
QLWVQEQKATQKAIK	CFAP77	226	Q6ZQR2
WVITAVNTNKVIQIN	CSMD3	576	Q7Z407
TQSEVQNLWKENLII	CPED1	906	A4D0V7
NEVQTTVKRQWAQFK	CALCR	396	P30988
PQIINSKWEKVQQLV	ACTN4	616	O43707
EAQLNKENWTVVKTL	CHAF1B	111	Q13112
ASLQNQIVWKIKETV	ALDH3A2	251	P51648
ATNIVKWITKQQNAQ	A2M	1231	P01023
QATKQFLEEINKWTV	PTPN9	21	P43378
QQNKVLETKWELLQQ	KRT76	206	Q01546
VNQIVTTNVRLKQQW	CHRNA1	66	P02708
QKVIQSIEQQKPNWI	KIAA0825	1071	Q8IV33
AVKLNKQQTDIAVNW	HDAC1	121	Q13547
QQNKVLETKWTLLQE	KRT6A	186	P02538
NDVISIWEKKLNQQA	GOLGA4	1041	Q13439
QWEVTQATQNTVKEL	FYCO1	301	Q9BQS8
KVNDEIIIKWVNQTL	PLS1	516	Q14651
NQQNLTEWIEILKTV	IPO7	221	O95373
QVLQTKWELLQQVDT	KRT1	206	P04264
IQLEWLQVQTVQCEK	FAM217B	186	Q9NTX9
IQAESEKWQQALKSV	PSMD12	256	O00232
LEQSNSKLEVQIKQW	KRT20	91	P35900
INEVKTWSNRITEKQ	IKBIP	126	Q70UQ0
QWQAISLTVIEKVQI	MARCHF9	171	Q86YJ5
SQVQKELQSINQKWV	MACF1	4656	Q9UPN3
QITAQQINKLEELWK	UPF1	256	Q92900
KIVQILPWEQNEQVK	APOB	576	P04114
KTQEIIPTQAKWQEV	COG1	656	Q8WTW3
ETQELKWQKETLQNQ	CCDC73	61	Q6ZRK6
TEKNTWKNIQDLSIV	DNAH14	1961	Q0VDD8
VQLSEIQDQKWTVKP	SACS	1851	Q9NZJ4
TWQKLKEAVEAIQNS	CUL4B	216	Q13620
NEKNWEKTLQINLVS	HPGD	96	P15428
QETQKRLSEVWQKVS	PMFBP1	236	Q8TBY8
VWTQKENQQLIKEVD	TACC3	96	Q9Y6A5
AVNQWKETVINPEKV	TC2N	466	Q8N9U0
ESTAQKRIEEWKQQQ	FNBP4	971	Q8N3X1
TWEAETIIQKIKQQQ	INPP5D	596	Q92835
WSNVEKVVQFKQQSR	SRCAP	206	Q6ZRS2
QQRWKLQVQEQRKTV	TMEM9	161	Q9P0T7
TQESVKWEINVIIKN	VPS13A	1546	Q96RL7
QQIWEKSIEQTQIKG	PHTF1	21	Q9UMS5
AIVSQWQQESKEKVV	SAMD4B	66	Q5PRF9
QIQVKREELITNWEQ	SPTAN1	331	Q13813
LNGEVQLEVQKKWQQ	SCTR	391	P47872
KEVVNIQTWINKPDV	TBC1D23	576	Q9NUY8
IIVWDIQNLQKVNTI	TRAF7	461	Q6Q0C0
TEVQKNQVLTLEEWQ	TPMT	16	P51580
WEQVIQQVTKKKQEL	ZNF106	791	Q9H2Y7
GIINQWQQESKDKVI	SAMD4A	66	Q9UPU9
KQIWESKAQTEVQLQ	GOLGB1	2261	Q14789
EWKQQLQQKAVASEI	MYO1C	866	O00159