Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

SPATA31A3 MYO9B SPATA31A7 SPIRE1 SPATA31A6 SPATA31C1 SPATA31A5 MEFV SPTBN4 SPATA31A1 MICALL2 PHACTR4 FHDC1

7.88e-0747910013GO:0003779
GeneOntologyMolecularFunctioncytoskeletal protein binding

DLG5 SPATA31A3 MYO9B SPATA31A7 LMTK2 SPIRE1 GOLGA8K SPATA31A6 SPATA31C1 SPATA31A5 MEFV SPTBN4 ADORA2A SPATA31A1 MICALL2 PHACTR4 FHDC1 FAM110C GOLGA2

1.91e-06109910019GO:0008092
GeneOntologyMolecularFunctionphosphatase binding

SHC1 SPTBN4 PHACTR4 DLG3 PPP6R2 LILRB5 LILRB4

3.67e-042641007GO:0019902
GeneOntologyCellularComponentacrosomal vesicle

SPATA31A3 SPATA31A7 PPFIA3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A1

5.64e-05206997GO:0001669
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31C1 SPATA31A5

1.51e-1112976PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31C1 SPATA31A5

1.51e-1112976IPR027970
DomainGUANYLATE_KINASE_2

DLG5 PALS1 DLG3 CARD14

5.61e-0623974PS50052
DomainGUANYLATE_KINASE_1

DLG5 PALS1 DLG3 CARD14

5.61e-0623974PS00856
DomainGuanylate_kin

DLG5 PALS1 DLG3 CARD14

9.36e-0626974PF00625
DomainGK/Ca_channel_bsu

DLG5 PALS1 DLG3 CARD14

9.36e-0626974IPR008145
DomainGuanylate_kin-like_dom

DLG5 PALS1 DLG3 CARD14

9.36e-0626974IPR008144
DomainGuKc

DLG5 PALS1 DLG3 CARD14

9.36e-0626974SM00072
DomainSH3

DLG5 STAC3 PPP1R13B PALS1 STAC2 SHANK2 DLG3

1.34e-04216977SM00326
DomainSH3

DLG5 STAC3 PPP1R13B PALS1 STAC2 SHANK2 DLG3

1.34e-04216977PS50002
DomainSH3_domain

DLG5 STAC3 PPP1R13B PALS1 STAC2 SHANK2 DLG3

1.50e-04220977IPR001452
DomainSH3_2

STAC3 PALS1 STAC2 SHANK2

1.05e-0386974IPR011511
DomainSH3_2

STAC3 PALS1 STAC2 SHANK2

1.05e-0386974PF07653
DomainPDZ

DLG5 PALS1 SHANK2 DLG3 CARD14

1.05e-03148975SM00228
Domain-

DLG5 PALS1 SHANK2 DLG3 CARD14

1.11e-031509752.30.42.10
DomainPDZ

DLG5 PALS1 SHANK2 DLG3 CARD14

1.15e-03151975PS50106
DomainPDZ

DLG5 PALS1 SHANK2 DLG3 CARD14

1.18e-03152975IPR001478
DomainBAH

TNRC18 BAHCC1

1.42e-0311972SM00439
DomainBAH

TNRC18 BAHCC1

1.42e-0311972PF01426
DomainBAH

TNRC18 BAHCC1

1.42e-0311972PS51038
DomainBAH_dom

TNRC18 BAHCC1

1.42e-0311972IPR001025
DomainOAR

RAX PITX1

2.68e-0315972PF03826
DomainHomeobox_CS

CUX2 RAX DBX1 PITX1 NKX2-2

2.86e-03186975IPR017970
DomainOAR

RAX PITX1

3.06e-0316972PS50803
DomainGuanylate_kinase_CS

PALS1 DLG3

3.06e-0316972IPR020590
DomainOAR_dom

RAX PITX1

3.06e-0316972IPR003654
DomainC1_1

MYO9B STAC3 STAC2

3.24e-0357973PF00130
DomainZF_DAG_PE_1

MYO9B STAC3 STAC2

4.50e-0364973PS00479
DomainZF_DAG_PE_2

MYO9B STAC3 STAC2

4.50e-0364973PS50081
DomainC1

MYO9B STAC3 STAC2

4.70e-0365973SM00109
DomainPE/DAG-bd

MYO9B STAC3 STAC2

4.90e-0366973IPR002219
DomainPDZ

DLG5 PALS1 SHANK2 DLG3

6.27e-03141974PF00595
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A1

5.48e-166102620850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A1

5.48e-166102625930072
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A1

7.07e-1124102632212159
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TBC1D9B MYO9B SHC1 LMTK2 SPIRE1 WRAP53 MBD6 BCR TRRAP FAM83H PRR12 TNRC18 SLC38A10 SHANK2 PITX1 BAHCC1

1.42e-0711051021635748872
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

VGF NHSL2 GOLGA8K ZNF318 PPFIA3 BCR SPTBN4 PALS1 SHANK2 BASP1 DLG3 PPP6R2 NOP2 UNC79 GOLGA2

1.43e-079631021528671696
Pubmed

DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130.

GOLGA2 DGAT1

8.52e-062102230816200
Pubmed

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.

BOC DBX1 NKX2-2

8.71e-0614102321664576
Pubmed

A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.

BOC DBX1 NKX2-2

1.09e-0515102325458012
Pubmed

Protein phosphatase 1γ isoforms linked interactions in the brain.

LMTK2 PPP1R13B ZNF318 PHACTR4

2.44e-0557102423080069
Pubmed

P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2.

SHC1 BCR

2.55e-05310229209414
Pubmed

Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye.

GOLGA8K PALS1 GOLGA2

4.16e-0523102325636444
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

DLG5 LARP1 PPP1R13B FAM83H NUDT5 SHANK2 PHACTR4 FAM110C GOLGA2

4.44e-05565102925468996
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DLG5 CARMIL2 TEX2 LMTK2 LARP1 SPIRE1 GIGYF1 PLEKHG2 BCR FAM83H PHACTR4

4.62e-058611021136931259
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

PPP1R13B GIGYF1 PPFIA3 MICALL2 DLG3 PPP6R2

4.62e-05218102633378226
Pubmed

Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.

SHANK2 DLG3

5.09e-054102210373412
Pubmed

Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1.

STAC3 STAC2

5.09e-054102229467163
Pubmed

TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections.

BCR UNC93B1

5.09e-054102231433296
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DLG5 MYO9B PPP1R13B ZNF318 ZNF593 BCR NUDT5 PPP6R2 GOLGA2

6.03e-05588102938580884
Pubmed

Dual function of Yap in the regulation of lens progenitor cells and cellular polarity.

GOLGA8K PALS1 GOLGA2

6.06e-0526102324384391
Pubmed

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

PSME1 NFE2L1

8.47e-055102229400713
Pubmed

A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.

UNC79 BAHCC1

8.47e-055102216807365
Pubmed

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

SHC1 BCR

8.47e-05510228112292
Pubmed

Identification of proteins interacting with the rat somatostatin receptor subtype 2.

SHANK2 DLG3

8.47e-055102211087996
Pubmed

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.

RAX GLS NKX2-2

9.39e-0530102329972793
Pubmed

Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice.

DLG5 GOLGA8K GOLGA2

1.04e-0431102317765678
Pubmed

Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

BOC PLEKHG2 TBRG1 NFE2L1

1.18e-0485102415449545
Pubmed

Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.

BOC NKX2-2

1.27e-046102225231763
Pubmed

Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility.

STAC3 STAC2

1.27e-046102223818578
Pubmed

Gata2 specifies serotonergic neurons downstream of sonic hedgehog.

DBX1 NKX2-2

1.27e-046102214973276
Pubmed

Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation.

PITX1 NKX2-2

1.27e-04610229347917
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

HYOU1 LARP1 GIGYF1 BCR PRR12 PALS1 PPP6R2 GOLGA2 USP33

1.29e-04650102938777146
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

DLG5 HYOU1 PPP1R13B ZNF318 GIGYF1 GOLGA2

1.30e-04263102634702444
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

BCR BASP1 GLS PPP6R2 CARD14

1.38e-04167102525659891
Pubmed

Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains.

GOLGA8K PALS1 GOLGA2

1.77e-0437102325742799
Pubmed

Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.

LILRB5 LILRB4

1.77e-047102217998301
Pubmed

IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever.

RIPK3 MEFV

1.77e-047102227998728
Pubmed

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.

DBX1 NKX2-2

1.77e-047102220532235
Pubmed

Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein.

TMEM98 NKX2-2

1.77e-047102230249802
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

MYO9B PLEKHG2 BCR

1.92e-0438102319911011
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DLG5 HYOU1 PPP1R13B PSME1 PLEKHG2 BCR FAM83H NUDT5 PHACTR4 PPP6R2

2.09e-048531021028718761
Pubmed

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

LILRB5 LILRB4

2.36e-04810229548455
Pubmed

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.

DLG5 DLG3

2.36e-048102223397623
Pubmed

The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.

SHANK2 DLG3

2.36e-048102210958799
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

TEX2 SHC1 LARP1 NUDT5 BASP1 PHACTR4 GOLGA2 USP33

2.76e-04568102837774976
Pubmed

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.

BOC NKX2-2

3.03e-049102216647304
Pubmed

The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.

SHC1 BCR

3.03e-04910228995379
Pubmed

Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.

RIPK3 UNC93B1

3.03e-049102229212904
Pubmed

The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development.

BOC NKX2-2

3.03e-049102233060130
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CUX2 HYOU1 RARRES1 NHSL2 LARP1 ZNF318 SPTBN4 TNRC18 C6orf118 SHANK2 GLS DLG3 BAHCC1

3.07e-0414421021335575683
Pubmed

Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons.

DBX1 NKX2-2

3.77e-0410102229719245
Pubmed

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.

LILRB5 LILRB4

3.77e-0410102218802077
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

DLG5 SPIRE1 ZNF318 WRAP53 ZNF593 TRRAP PRR12 SHANK2 MICALL2 DLG3 DGCR8 UNC93B1 DGAT1

4.39e-0414971021331527615
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

MYO9B R3HCC1 LARP1 TNRC18 NFE2L1 NOP2

4.52e-04332102637433992
Pubmed

Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins.

DBX1 NKX2-2

4.60e-0411102216364285
Pubmed

Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.

LRP10 GOLGA2

4.60e-0411102215101818
Pubmed

Commissural axonal corridors instruct neuronal migration in the mouse spinal cord.

BOC NKX2-2

4.60e-0411102225960414
Pubmed

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.

RIPK3 MEFV

4.60e-0411102232298652
Pubmed

DGKι regulates presynaptic release during mGluR-dependent LTD.

SHANK2 DLG3

4.60e-0411102221119615
Pubmed

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.

SHC1 BCR

4.60e-041110229872323
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

TEX2 LMTK2 PPFIA3 BCR AMER2 TNRC18 SHANK2 BASP1 GLS DLG3 PPP6R2

5.20e-0411391021136417873
Pubmed

RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling.

RIPK3 MEFV

5.51e-0412102232989095
Pubmed

p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.

SHC1 BCR

5.51e-041210228621719
Pubmed

TMED2 binding restricts SMO to the ER and Golgi compartments.

DBX1 NKX2-2

5.51e-0412102235353806
Pubmed

Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord.

DBX1 NKX2-2

5.51e-0412102225331329
Pubmed

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

RIPK3 MEFV

5.51e-0412102230451870
Pubmed

Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms.

DLG5 MYO9B

5.51e-0412102218804983
Pubmed

ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling.

DBX1 NKX2-2

5.51e-0412102231336385
Pubmed

Interaction network of human early embryonic transcription factors.

HYOU1 MBD6 PRR12 TNRC18 PITX1 BAHCC1

6.05e-04351102638297188
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

ICA1 SLC45A4 PHACTR4 DLG3 USP33

6.35e-04233102537704626
Pubmed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.

CUX2 FOXA3 PITX1

6.39e-0457102321122108
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TBC1D9B SLC45A4 PRR12 TNRC18 GLS FHDC1 PPP6R2

6.39e-04493102715368895
Pubmed

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.

RIPK3 MEFV

6.50e-0413102234686350
Pubmed

Globozoospermia and lack of acrosome formation in GM130-deficient mice.

GOLGA8K GOLGA2

6.50e-0413102228055014
Pubmed

GM130 regulates pulmonary surfactant protein secretion in alveolar type II cells.

GOLGA8K GOLGA2

6.50e-0413102233740186
Pubmed

Loss of GM130 does not impair oocyte meiosis and embryo development in mice.

GOLGA8K GOLGA2

6.50e-0413102232873390
Pubmed

GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte.

GOLGA8K GOLGA2

6.50e-0413102221552007
Pubmed

GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver.

GOLGA8K GOLGA2

6.50e-0413102229128360
Pubmed

Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice.

GOLGA8K GOLGA2

6.50e-0413102228028212
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

LMTK2 LARP1 ZNF318 PRR12 PITX1 NOP2

7.00e-04361102630344098
Pubmed

A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling.

DBX1 NKX2-2

7.57e-0414102219776033
Pubmed

Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.

CUX2 NKX2-2

7.57e-0414102218223201
Pubmed

GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.

GOLGA8K GOLGA2

7.57e-0414102230630895
Pubmed

Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis.

DBX1 NKX2-2

7.57e-0414102225721514
Pubmed

Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation.

GOLGA8K GOLGA2

7.57e-0414102237831422
Pubmed

Golgb1 regulates protein glycosylation and is crucial for mammalian palate development.

GOLGA8K GOLGA2

7.57e-0414102227226319
Pubmed

Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice.

GOLGA8K GOLGA2

7.57e-0414102233543287
Pubmed

GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.

GOLGA8K GOLGA2

8.72e-0415102226165940
Pubmed

Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum.

GOLGA8K GOLGA2

8.72e-0415102217204322
Pubmed

Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain.

GOLGA8K GOLGA2

8.72e-0415102216413118
Pubmed

Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning.

DBX1 NKX2-2

8.72e-0415102223900540
Pubmed

Golgi disruption and early embryonic lethality in mice lacking USO1.

GOLGA8K GOLGA2

8.72e-0415102223185636
Pubmed

The a3 isoform of V-ATPase regulates insulin secretion from pancreatic beta-cells.

GOLGA8K GOLGA2

8.72e-0415102217046993
Pubmed

Mouse oocytes within germ cell cysts and primordial follicles contain a Balbiani body.

GOLGA8K GOLGA2

8.72e-0415102217189423
Pubmed

RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis.

GOLGA8K GOLGA2

8.72e-0415102226083584
Pubmed

WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.

GOLGA8K GOLGA2

8.72e-0415102237635409
Pubmed

Golga5 is dispensable for mouse embryonic development and postnatal survival.

GOLGA8K GOLGA2

8.72e-0415102228509431
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

DLG5 LARP1 ZNF318 BASP1 GOLGA2

9.68e-04256102533397691
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

ICA1 SHC1 ZNF318 GIGYF1 TNRC18 USP42 SKOR2 GLS

9.75e-04689102836543142
Pubmed

LIM kinase 2 is widely expressed in all tissues.

GOLGA8K GOLGA2

9.95e-0416102216399995
Pubmed

Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord.

DBX1 NKX2-2

9.95e-0416102219258013
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

1.36e-0481022chr9q12
Cytoband9p13.1

SPATA31A3 SPATA31A1

1.31e-032410229p13.1
CytobandEnsembl 112 genes in cytogenetic band chr19q13

DPY19L3 PLEKHG2 PPFIA3 FOXA3 SPTBN4 PRR12 LIG1 LILRB5 LILRB4

1.38e-0311921029chr19q13
Cytoband14q32.12

CCDC197 UNC79

1.91e-0329102214q32.12
Cytoband8q24.3

FAM83H SLC45A4 DGAT1

2.09e-0311310238q24.3
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

DLG5 PALS1 DLG3 CARD14

1.66e-0626614904
GeneFamilyCD molecules|Inhibitory leukocyte immunoglobulin like receptors

LILRB5 LILRB4

1.11e-0456121182
GeneFamilyPDZ domain containing

DLG5 PALS1 SHANK2 DLG3 CARD14

1.60e-041526151220
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

LMTK2 PPP1R13B PHACTR4 DLG3

3.25e-03181614694
GeneFamilySterile alpha motif domain containing

EPHB6 PPFIA3 SHANK2

3.27e-0388613760
ToppCellfacs-Trachea-nan-18m-Epithelial-mucus_secreting_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A3 GIGYF1 MBD6 SPTBN4 SHANK2 NKX2-2

2.24e-0616510267e7643834ed483aec04f513cca38d6367fda9ff8
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VGF PELI3 FOXA3 ERICH5 SPTBN4 NKX2-2

3.35e-06177102643dce527392f3b8364bb6a55268ce9d6518d3a29
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VGF PPFIA3 KCNH4 SPTBN4 BASP1 DLG3

5.51e-061931026be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VGF PPFIA3 KCNH4 SPTBN4 BASP1 DLG3

5.51e-0619310260c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VGF PPFIA3 KCNH4 SPTBN4 BASP1 DLG3

5.51e-0619310268689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CUX2 TEX2 ZNF710 NOP2 LILRB4

1.44e-0513410250e3f37ef041b751ed45060b5ce39385a2731370b
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ICA1 ADORA2A NOP2 LILRB5 TDRP

3.58e-05162102564353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ICA1 ADORA2A NOP2 LILRB5 TDRP

3.68e-0516310259f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCellfacs-Trachea-nan-18m-Myeloid-granulocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RARRES1 MEFV BASP1 FAM110C LILRB4

4.02e-0516610257f8b4cf63c3e292ae421f111edaa4572717f4db1
ToppCellfacs-Aorta-Heart-24m-Myeloid-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR46 ZNF593 BASP1 NOP2 LILRB4

4.13e-051671025b85fd7ab21c80470bca804c788ce49a2bce763f8
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMTK2 FAM83H STAC2 SHANK2 UNC79

4.13e-0516710259efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMTK2 FAM83H STAC2 SHANK2 UNC79

4.13e-051671025904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|390C / Donor, Lineage, Cell class and subclass (all cells)

RIPK3 MYO9B DGCR8 LILRB5 LILRB4

4.50e-051701025439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLEKHG2 MEFV ZNF469 LILRB5 LILRB4

5.90e-05180102566c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH4 SLC45A4 RP1L1 NKX2-2 FHDC1

6.38e-05183102512e876d6205af8aad74265c668b5e95b9e7487f3
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUX2 FAM83H PITX1 DNAAF1 FAM110C

6.38e-051831025ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCellfacs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUX2 FAM83H PITX1 DNAAF1 FAM110C

6.38e-051831025f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

ZBTB7C ZNF710 TNRC18 PHACTR4 PPP6R2

6.89e-051861025de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ZBTB7C ZNF710 TNRC18 PHACTR4 PPP6R2

6.89e-0518610250b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VGF PPFIA3 KCNH4 SPTBN4 BASP1

6.89e-0518610257278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCelldroplet-Marrow-BM-1m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPK3 HYOU1 WDR46 ZNF593 NOP2

7.43e-051891025b81540e097e95158851e07bfd78640ed6e64c2cf
ToppCelldroplet-Marrow-BM-1m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPK3 HYOU1 WDR46 ZNF593 NOP2

7.43e-0518910250fda1a3f1e87fadf5309c8267beaa4501983b1dd
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 C6orf118 MICALL2 NKX2-2 UNC79

7.62e-051901025e2481bd5166fde2cdc0c3824894f2bccb8294fdd
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A3 ICA1 LMTK2 PPP1R13B SHANK2

8.20e-051931025a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell10x3'2.3-week_12-13-Myeloid_DC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ERICH5 ZNF710 NUDT5 UNC93B1 LILRB4

8.40e-05194102566dd0469db797c61b094f47426b5212fe52156e9
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LMTK2 PPP1R13B SPIRE1 SHANK2 FHDC1

8.40e-05194102597534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ERICH5 ZNF710 NUDT5 UNC93B1 LILRB4

8.40e-051941025840220fe357e6e79fb60a530798be2dc12ce8f32
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ICA1 SPTBN4 SHANK2 GLS UNC79

8.82e-051961025676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ICA1 SPTBN4 SHANK2 GLS UNC79

9.25e-051981025c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ICA1 SPTBN4 SHANK2 GLS UNC79

9.25e-0519810256d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ICA1 SPTBN4 SHANK2 GLS UNC79

9.25e-0519810254ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ICA1 SPTBN4 SHANK2 GLS UNC79

9.25e-0519810250ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

RARRES1 BASP1 LILRB5 CARD14 LILRB4

9.47e-051991025f987f48970aec46156b80656e49b9f3604f3758c
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ICA1 SPTBN4 SHANK2 GLS UNC79

9.69e-05200102548d801219bc771d6c7e151dc88ca4c179988de85
DrugDimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; MCF7; HT_HG-U133A

VGF DLG5 MYO9B ZNF318 ZNF710 MICALL2 DNAAF1 GOLGA2

1.96e-061989684791_DN
DrugRapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A

TBC1D9B LARP1 PPFIA3 WRAP53 DGCR8 PPP6R2 GOLGA2

1.90e-051959671207_DN
DrugEpicatechin-(-) [154-23-4]; Down 200; 13.8uM; PC3; HT_HG-U133A

VGF TBC1D9B MYO9B ZNF318 BCR DLG3 BAHCC1

1.96e-051969674594_DN
DrugPraziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A

COL4A3 MYO9B ICA1 ZNF710 SHANK2 GLS DGCR8

2.03e-051979673189_UP
DrugTheophylline monohydrate [5967-84-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A

MYO9B ZNF318 PPFIA3 ADORA2A GLS PITX1 PPP6R2

2.10e-051989673326_DN
DrugDiflunisal [22494-42-4]; Down 200; 16uM; MCF7; HT_HG-U133A

TBC1D9B ZNF318 GLS PITX1 DNAAF1 PPP6R2 GOLGA2

2.10e-051989674794_DN
Diseaserenal overload-type gout

SPATA31C2 SPATA31C1

1.53e-046952EFO_0021525
Diseaseeosinophil cationic protein measurement

SPATA31C2 SPATA31C1

2.84e-048952EFO_0010913
Diseaselongitudinal alcohol consumption measurement

SPATA31C2 SPATA31C1

3.64e-049952EFO_0007645
Diseaseegg allergy measurement, parental genotype effect measurement

SPATA31C2 SPATA31C1

7.82e-0413952EFO_0005939, EFO_0007018
Diseaseamygdala volume change measurement

SPATA31C2 SPATA31C1

1.20e-0316952EFO_0021490
Diseasehemoglobin A1 measurement

DLG5 ZBTB7C MYO9B LARP1 RP1L1 CHFR DGAT1

1.47e-03520957EFO_0007629
Diseasecancer (implicated_via_orthology)

CUX2 LIG1 DLG3 NKX2-2 NOP2

1.77e-03268955DOID:162 (implicated_via_orthology)
Diseasemean corpuscular hemoglobin concentration

CUX2 DPY19L3 MYO9B LARP1 ZNF318 GIGYF1 FOXA3 MEFV C6orf118 RP1L1

2.96e-0311059510EFO_0004528

Protein segments in the cluster

PeptideGeneStartEntry
GPQGKAADPSPLEGL

BAHCC1

1171

Q9P281
GEPAGGEEVPAPADR

AMER2

261

Q8N7J2
DPDGSPATLPGGKDN

AMER2

561

Q8N7J2
ELDAKGDPGLPGAPG

COL4A3

166

Q01955
EPPGLDDPLAQDGAG

ADORA2A

396

P29274
EEPEARPDGEGSPGK

BCR

111

P11274
PELAAPGEDAEPQAG

CARMIL2

971

Q6F5E8
DGPGENDPDLKPADH

DPY19L3

666

Q6ZPD9
DPGPPDEKDPLGAEA

DGCR8

401

Q8WYQ5
KQEEGSGGPAQAPLP

CUX2

746

O14529
GAAGDAPAPAPNKDG

DGAT1

41

O75907
APAPAPNKDGDAGVG

DGAT1

46

O75907
DPSNPGDKEGDLQGL

CCDC197

11

Q8NCU1
EKEPEQDGPAAPADG

PPP1R13B

646

Q96KQ4
GEAPGPESGPELEAN

ANKRD63

341

C9JTQ0
ANDTAGPELPDPLGG

NFE2L1

426

Q14494
APAGRDPEEPGDVGA

R3HCC1

161

Q9Y3T6
EKTGPDPLPIGEDGL

INTS6L

236

Q5JSJ4
AAPGPKDGPGETDAF

GLS

101

O94925
GPGAPAPQELGAADK

GOLGA8S

551

H3BPF8
SPALEDGKAAPDEPG

FHDC1

736

Q9C0D6
KGEPGPNDVRGGEPD

LARP1

36

Q6PKG0
NGELAEGGAEPKDPP

MBD6

916

Q96DN6
GGQDGEQAPPLPIKA

LRP10

606

Q7Z4F1
EEGPEAGGKELTPLP

GIGYF1

346

O75420
PPGAAEPEPKDGGLQ

LILRB4

301

Q8NHJ6
PKEEAGAPRGEGPAI

PPFIA3

696

O75145
PGPAAGGEAPKAAEA

BASP1

111

P80723
EGAGGPPPKTDQALA

MICALL2

166

Q8IY33
DDAENARPKPKPGDG

NUDT5

151

Q9UKK9
KGPGNEEEEEGPGSP

DBX1

271

A6NMT0
DDSPAKGPDGLVPGD

DLG5

1531

Q8TDM6
ADIPEPGQEPGLGAD

KCNH4

621

Q9UQ05
DPGPGKQDDSGQDVP

LMTK2

516

Q8IWU2
PAGAAGPEPKDQGLQ

LILRB5

496

O75023
PTPDGGASADLKEGP

MEFV

281

O15553
QKEPEAAAPAPGTGG

GOLGA2

776

Q08379
EDPEQGGEDPGKPSD

PHACTR4

86

Q8IZ21
GDEDNQPLAGLVPGK

PALS1

396

Q8N3R9
GPLAGAKPVQEEGDP

OTOS

16

Q8NHW6
APEGEPGAPQALGDA

CHFR

446

Q96EP1
EGDRVKAPPDAAPGL

CEFIP

966

Q711Q0
EAGPEGVAPAPEGEK

HYOU1

671

Q9Y4L1
PLELGGPGAEPEQKE

HYOU1

971

Q9Y4L1
GPGAPAPQELGAADK

GOLGA8K

556

D6RF30
QCPGEKGQGAPAEAP

BOC

461

Q9BWV1
PEGDPGALPGAKAGD

CARD14

506

Q9BXL6
PKGERASEVGEPPAG

C6orf118

86

Q5T5N4
AGGIDNPHVPDDPGI

DLG3

146

Q92796
GEEPPVEAKREDGGP

DNAAF1

396

Q8NEP3
GPEREGPEEPGLAKQ

FAM83H

651

Q6ZRV2
PQPGGKEDAPAAEGK

ERICH5

116

Q6P6B1
EEPGAPGKEGAAEGP

LIG1

246

P18858
PGKEGAAEGPLDPSG

LIG1

251

P18858
PVPRTGDEGKAGNPE

FAM110C

136

Q1W6H9
GPVDVPGREDGKEAP

SLC38A10

461

Q9HBR0
PAKEDLGPGDRGLHP

SLC38A10

591

Q9HBR0
KGEDEDKGPPCGPVN

PSME1

91

Q06323
PGKKEAPPVEGDSEG

PPP6R2

696

O75170
GKTDAPPEGAALNGP

PPP6R2

951

O75170
LGPVAGTPEPEGADK

ICA1

356

Q05084
PEKERGGEPKGPEDS

PITX1

56

P78337
DTDGPGNDGKPEPVL

WRAP53

441

Q9BUR4
EPVAGDAVPGPKDGS

VGF

41

O15240
EKGDFGQLSGPDPPG

SPATA31C2

116

B4DYI2
EPGLLPEGGSALPKD

NHSL2

581

Q5HYW2
KGDFGQLSGPDPPGE

SPATA31A6

111

Q5VVP1
PGEDAQPGEEPIKYG

PELI3

31

Q8N2H9
PAPEPEAQGGEDVGA

FOXA3

256

P55318
KPDTLQAGGDPGERP

EPHB6

921

O15197
KGDFGQLSGPDPPGE

SPATA31A7

111

Q8IWB4
NEGPEPAKRAGPLGQ

NKX2-2

36

O95096
DTGVGPPNSEGKDPA

PRR12

896

Q9ULL5
DYGKAGPPEDEGDPK

PRR12

961

Q9ULL5
LEKGDFGQLSGPDPP

SPATA31C1

121

P0DKV0
PESGPPKVEEADGGL

NOP2

196

P46087
GPGFGDKFPLDEADP

RAX

306

Q9Y2V3
DLGDEDVGLGPPAPR

SHANK2

1106

Q9UPX8
PPAAGDPQAKAGGDT

TBC1D9B

1101

Q66K14
PLPDPQKAGGAEAEN

SLC45A4

21

Q5BKX6
KGDFGQLSGPDPPGE

SPATA31A3

111

Q5VYP0
GPKEPGFEAGPEASD

TNRC18

1976

O15417
GERVEDAAAPKAPGP

USP42

921

Q9H9J4
PQGDEDLLGVPDGPE

UNC93B1

16

Q9H1C4
EEEDGLRGGPPPAAA

TDRP

16

Q86YL5
KGDFGQLSGPDPPGE

SPATA31A1

111

Q5TZJ5
PQAGPETPGLEGLKE

RIPK3

246

Q9Y572
GDPGQDPEPEGALLG

RP1L1

1016

Q8IWN7
KGDFGQLSGPDPPGE

SPATA31A5

111

Q5VU36
AADDAGEPPPVAGKL

SPIRE1

101

Q08AE8
AESEGPGPEEKSPGQ

STAC2

266

Q6ZMT1
VPGDDKDAGPAEAPA

ZNF710

126

Q8N1W2
QEKEAGPGLPAGPSL

SPTBN4

2331

Q9H254
PGAGEPNFDGLESNP

WDR46

476

O15213
QEDGKLGDPGSDLPP

SKOR2

821

Q2VWA4
QEAGGDGAPANPEEP

ZNF469

1116

Q96JG9
DPNAEFDPDLPGGGL

ZNF593

46

O00488
DLPGGPLGPIKAEND

ZBTB7C

316

A1YPR0
LGEPPSGGKAGPEED

PLEKHG2

721

Q9H7P9
APEPSGGDKQLLPGA

TEX2

961

Q8IWB9
PEEGKPQDGNPEGDK

STAC3

216

Q96MF2
GDPDDPGQPQDAGVP

RARRES1

41

P49788
EKGEGEQLLGPPNPE

TRRAP

1786

Q9Y4A5
KSELDLGEPGPPGVE

ZNF318

1716

Q5VUA4
NDFPGKEPPLGGVVD

SHC1

351

P29353
KPGDGQLPEGLPEND

TBRG1

326

Q3YBR2
FVKGKDGDPPGPIDN

USP33

861

Q8TEY7
ASEPDKGLPGPEGFL

TMEM98

206

Q9Y2Y6
LDDHPDPGTEGEKPG

UNC79

1761

Q9P2D8
QGALEPLEEDGQPPG

MYO9B

2121

Q13459