Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

ATP6V1B2 MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 MSH3 IDE RFC1 MORC2 ATP10D DHX30 ACSF3 DDX24 VCP

1.13e-0561414616GO:0140657
GeneOntologyMolecularFunctionATP hydrolysis activity

MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 IDE RFC1 MORC2 ATP10D DHX30 DDX24 VCP

2.21e-0544114613GO:0016887
GeneOntologyMolecularFunctionDNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates

DNMT3A DNMT3B

5.31e-0521462GO:0051719
GeneOntologyMolecularFunctionspectrin binding

USH1C PTPRC CAMSAP1 CAMSAP2

1.07e-04341464GO:0030507
GeneOntologyMolecularFunctionmetalloexopeptidase activity

ERAP1 MEP1A ERAP2 ENPEP CNDP1

1.61e-04701465GO:0008235
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine phosphatase activity

PTPRC PTPRD PTPRE

2.42e-04171463GO:0005001
GeneOntologyMolecularFunctiontransmembrane receptor protein phosphatase activity

PTPRC PTPRD PTPRE

2.42e-04171463GO:0019198
GeneOntologyMolecularFunctionligase activity

TRIM25 FARSB AASDH CPS1 IARS2 ACSF3 PC

2.97e-041741467GO:0016874
GeneOntologyMolecularFunctiongroup III metabotropic glutamate receptor activity

GRM4 GRM8

3.16e-0441462GO:0001642
GeneOntologyMolecularFunctionDNA (cytosine-5-)-methyltransferase activity

DNMT3A DNMT3B

3.16e-0441462GO:0003886
GeneOntologyMolecularFunctionubiquitin-modified protein reader activity

ANKRD13D IDE VCP

3.98e-04201463GO:0140036
GeneOntologyMolecularFunctionubiquitin-like protein reader activity

ANKRD13D IDE VCP

7.83e-04251463GO:0140035
GeneOntologyMolecularFunctionmetalloaminopeptidase activity

ERAP1 ERAP2 ENPEP

8.80e-04261463GO:0070006
GeneOntologyMolecularFunctionpeptidase activity

ERAP1 USP25 IDE CPS1 USP9Y OVCH1 MEP1A MALT1 ERAP2 USP7 CFAP44 ENPEP CNDP1

1.04e-0365414613GO:0008233
GeneOntologyMolecularFunctioncentromeric DNA binding

MSH3 ZW10

1.09e-0371462GO:0019237
GeneOntologyMolecularFunctionDNA-methyltransferase activity

DNMT3A DNMT3B

1.09e-0371462GO:0009008
GeneOntologyMolecularFunctionpyrophosphatase activity

NUDT7 MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 IDE RFC1 MORC2 ATP10D MFN1 DHX30 DDX24 VCP

1.26e-0383914615GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

NUDT7 MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 IDE RFC1 MORC2 ATP10D MFN1 DHX30 DDX24 VCP

1.27e-0384014615GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

NUDT7 MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 IDE RFC1 MORC2 ATP10D MFN1 DHX30 DDX24 VCP

1.27e-0384014615GO:0016818
GeneOntologyMolecularFunctionexopeptidase activity

ERAP1 MEP1A ERAP2 ENPEP CNDP1

1.29e-031101465GO:0008238
GeneOntologyMolecularFunctioncalmodulin binding

GRM4 RYR3 KCNH1 IQCF3 CFAP221 CAMSAP1 CAMSAP2

1.54e-032301467GO:0005516
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 IDE RFC1 MORC2 ATP10D MFN1 DHX30 DDX24 VCP

1.66e-0377514614GO:0017111
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRM4 GRM8

1.85e-0391462GO:0098988
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRM4 GRM8

1.85e-0391462GO:0001640
GeneOntologyMolecularFunctionG-quadruplex RNA binding

PATL1 DHX30

2.30e-03101462GO:0002151
GeneOntologyMolecularFunctionmetallodipeptidase activity

MEP1A CNDP1

2.30e-03101462GO:0070573
GeneOntologyBiologicalProcesscellular catabolic process

AADAC ATP6V1B2 VPS18 NUDT7 ABHD12B ERAP1 RNF213 IDE HMOX1 ATG2A CPS1 EPG5 ARG2 AGXT2 PIK3C2A ERAP2 AASS FZD5 SCARB2 ACSF3 ATM WDFY3 ENPEP VCP SORL1

1.81e-06125314425GO:0044248
GeneOntologyBiologicalProcesspeptide catabolic process

ERAP1 IDE ERAP2 ENPEP

1.82e-05231444GO:0043171
DomainARM-type_fold

DOCK8 HEATR1 API5 USP9Y RYR3 PPP2R1B PIK3C2A NBEAL2 NCAPD2 ATM WDFY3 STAG3

1.03e-0533914112IPR016024
DomainERAP1-like_C_dom

ERAP1 ERAP2 ENPEP

2.29e-0581413IPR024571
DomainERAP1_C

ERAP1 ERAP2 ENPEP

2.29e-0581413PF11838
Domain-

ATP6V1B2 MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 MSH3 RFC1 PAPSS2 AK7 MFN1 DHX30 NDST3 DDX24 DYNC1LI2 VCP

4.83e-05746141173.40.50.300
DomainP-loop_NTPase

ATP6V1B2 MCM8 DNAH10 SMC1A DNAH2 PSMC5 RNF213 MSH3 RFC1 PAPSS2 AK7 MFN1 DHX30 NDST3 CAMTA1 DDX24 DYNC1LI2 VCP

7.14e-0584814118IPR027417
DomainPeptidase_M1

ERAP1 ERAP2 ENPEP

8.82e-05121413IPR001930
DomainAAA

MCM8 DNAH10 DNAH2 PSMC5 RNF213 RFC1 VCP

1.12e-041441417SM00382
DomainAAA+_ATPase

MCM8 DNAH10 DNAH2 PSMC5 RNF213 RFC1 VCP

1.12e-041441417IPR003593
DomainPeptidase_M1_N

ERAP1 ERAP2 ENPEP

1.14e-04131413IPR014782
DomainPeptidase_M1

ERAP1 ERAP2 ENPEP

1.14e-04131413PF01433
DomainCAMSAP_CC1

CAMSAP1 CAMSAP2

1.69e-0431412PF17095
DomainCAMSAP_CKK

CAMSAP1 CAMSAP2

1.69e-0431412SM01051
DomainPRC_barrel-like

CAMSAP1 CAMSAP2

1.69e-0431412IPR011033
DomainCKK_domain

CAMSAP1 CAMSAP2

1.69e-0431412IPR014797
DomainCAMSAP_CKK

CAMSAP1 CAMSAP2

1.69e-0431412PF08683
DomainCAMSAP_CC1

CAMSAP1 CAMSAP2

1.69e-0431412IPR031372
DomainCAMSAP

CAMSAP1 CAMSAP2

1.69e-0431412IPR032940
DomainCKK

CAMSAP1 CAMSAP2

1.69e-0431412PS51508
DomainARM-like

DOCK8 HEATR1 API5 USP9Y PPP2R1B NBEAL2 NCAPD2 WDFY3 STAG3

2.14e-042701419IPR011989
DomainArylacetamide_deacetylase

AADAC NCEH1

3.36e-0441412IPR017157
DomainC5_MTASE_1

DNMT3A DNMT3B

3.36e-0441412PS00094
DomainC5_MTASE_2

DNMT3A DNMT3B

3.36e-0441412PS00095
DomainLipase_GDXG_HIS_AS

AADAC NCEH1

3.36e-0441412IPR002168
DomainSAM_MT_C5

DNMT3A DNMT3B

3.36e-0441412PS51679
DomainDNA_methylase

DNMT3A DNMT3B

3.36e-0441412PF00145
DomainADD

DNMT3A DNMT3B

3.36e-0441412IPR025766
DomainLipase_GDXG_put_SER_AS

AADAC NCEH1

3.36e-0441412IPR033140
DomainC5_MeTfrase

DNMT3A DNMT3B

3.36e-0441412IPR001525
DomainC5_DNA_meth_AS

DNMT3A DNMT3B

3.36e-0441412IPR018117
DomainADD

DNMT3A DNMT3B

3.36e-0441412PS51533
DomainDUF4704

NBEAL2 WDFY3

5.58e-0451412IPR031570
DomainDUF4704

NBEAL2 WDFY3

5.58e-0451412PF15787
DomainTRAF-like

MEP1A USP7 PDZRN4

7.59e-04241413IPR008974
DomainUIM

ANKRD13D USP25 MNAT1

7.59e-04241413PS50330
DomainPH_BEACH

NBEAL2 WDFY3

8.32e-0461412PF14844
DomainLIPASE_GDXG_SER

AADAC NCEH1

8.32e-0461412PS01174
DomainLIPASE_GDXG_HIS

AADAC NCEH1

8.32e-0461412PS01173
DomainHR1_rho-bd

PSMC5 RTKN2 VPS53

8.58e-04251413IPR011072
DomainUIM_dom

ANKRD13D USP25 MNAT1

8.58e-04251413IPR003903
DomainCAMSAP_CH

CAMSAP1 CAMSAP2

1.16e-0371412PF11971
DomainCbamoylP_synth_lsu-like_ATP-bd

CPS1 PC

1.16e-0371412IPR005479
DomainAB_hydrolase_3

AADAC NCEH1

1.16e-0371412IPR013094
DomainBC-like_N

CPS1 PC

1.16e-0371412IPR005481
DomainAbhydrolase_3

AADAC NCEH1

1.16e-0371412PF07859
DomainCPSase_L_D2

CPS1 PC

1.16e-0371412PF02786
DomainCAMSAP_CH

CAMSAP1 CAMSAP2

1.16e-0371412IPR022613
DomainBiotin_carb_N

CPS1 PC

1.16e-0371412PF00289
DomainConA-like_dom

HSPG2 TRIM25 RYR3 MEP1A SLIT2 NBEAL2 WDFY3

1.39e-032191417IPR013320
DomainDHC_N1

DNAH10 DNAH2

1.54e-0381412PF08385
DomainGPCR_3_mtglu_rcpt

GRM4 GRM8

1.54e-0381412IPR000162
DomainPH-BEACH_dom

NBEAL2 WDFY3

1.54e-0381412IPR023362
Domain-

NBEAL2 WDFY3

1.54e-03814122.30.29.40
DomainPH_BEACH

NBEAL2 WDFY3

1.54e-0381412PS51783
DomainDynein_heavy_dom-1

DNAH10 DNAH2

1.54e-0381412IPR013594
Domain-

HSPG2 TNC PTK7 MST1R MALT1 LY6G6F PTPRC PTPRD HMCN1 UNC5C CAMTA1 KIT SORL1

1.56e-03663141132.60.40.10
DomainBEACH

NBEAL2 WDFY3

1.97e-0391412PS50197
DomainBeach

NBEAL2 WDFY3

1.97e-0391412PF02138
Domain-

NBEAL2 WDFY3

1.97e-03914121.10.1540.10
DomainBeach

NBEAL2 WDFY3

1.97e-0391412SM01026
DomainBEACH_dom

NBEAL2 WDFY3

1.97e-0391412IPR000409
DomainIGc2

HSPG2 PTK7 MALT1 PTPRD HMCN1 UNC5C KIT

2.07e-032351417SM00408
DomainIg_sub2

HSPG2 PTK7 MALT1 PTPRD HMCN1 UNC5C KIT

2.07e-032351417IPR003598
DomainPAS_9

KCNH6 KCNH1

2.45e-03101412PF13426
DomainPTPc

PTPRC PTPRD PTPRE

2.51e-03361413SM00194
DomainEGF

HSPG2 TNC MEP1A SLIT2 HMCN1

2.69e-031261415PF00008
DomainIg-like_fold

HSPG2 TNC PTK7 MST1R MALT1 LY6G6F PTPRC PTPRD HMCN1 UNC5C CAMTA1 KIT SORL1

2.69e-0370614113IPR013783
DomainLaminin_G_1

HSPG2 SLIT2

2.98e-03111412PF00054
DomainTYR_PHOSPHATASE_PTP

PTPRC PTPRD PTPRE

3.16e-03391413PS50055
DomainMATH

MEP1A USP7

3.55e-03121412PS50144
DomainMATH/TRAF_dom

MEP1A USP7

3.55e-03121412IPR002083
DomainMATH

MEP1A USP7

3.55e-03121412SM00061
DomainMATH

MEP1A USP7

3.55e-03121412PF00917
DomainPTPase_domain

PTPRC PTPRD PTPRE

3.64e-03411413IPR000242
DomainY_phosphatase

PTPRC PTPRD PTPRE

3.64e-03411413PF00102
Domain-

CPS1 PC

4.18e-031314123.40.50.20
DomainNCD3G

GRM4 GRM8

4.18e-03131412PF07562
DomainGPCR_3_9-Cys_dom

GRM4 GRM8

4.18e-03131412IPR011500
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH2

4.85e-03141412IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH2

4.85e-03141412IPR024743
DomainDynein_heavy_dom-2

DNAH10 DNAH2

4.85e-03141412IPR013602
DomainDHC_N2

DNAH10 DNAH2

4.85e-03141412PF08393
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH2

4.85e-03141412IPR011704
DomainATP_GRASP

CPS1 PC

4.85e-03141412PS50975
DomainK_chnl_volt-dep_EAG/ELK/ERG

KCNH6 KCNH1

4.85e-03141412IPR003938
DomainATP-grasp

CPS1 PC

4.85e-03141412IPR011761
DomainPreATP-grasp_dom

CPS1 PC

4.85e-03141412IPR016185
DomainMT

DNAH10 DNAH2

4.85e-03141412PF12777
DomainAAA_8

DNAH10 DNAH2

4.85e-03141412PF12780
DomainGPCR_3_CS

GRM4 GRM8

4.85e-03141412IPR017979
DomainAAA_5

DNAH10 DNAH2

4.85e-03141412PF07728
DomainDHC_fam

DNAH10 DNAH2

5.57e-03151412IPR026983
DomainDynein_heavy

DNAH10 DNAH2

5.57e-03151412PF03028
DomainPI3/4_kinase_CS

PIK3C2A ATM

5.57e-03151412IPR018936
DomainDynein_heavy_dom

DNAH10 DNAH2

5.57e-03151412IPR004273
Domain-

CPS1 PC

5.57e-031514123.30.1490.20
DomainHEAT

HEATR1 PPP2R1B NCAPD2

5.68e-03481413PF02985
Domain-

PIK3C2A ATM

6.34e-031614121.10.1070.11
DomainPI3Kc

PIK3C2A ATM

6.34e-03161412SM00146
DomainZINC_PROTEASE

ERAP1 MEP1A ERAP2 ENPEP

6.50e-03981414PS00142
Domain-

HEATR1 API5 PPP2R1B NCAPD2 WDFY3 STAG3

6.84e-0322214161.25.10.10
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MAP3K8 SMC1A FARSB MSH3 HEATR1 CPS1 MORC2 GTF3C3 IARS2 SUGP2 NFIA MORF4L2 NCAPD2 SLMAP CCDC15 CAMSAP1 DDX24 RPA3 KIT SORL1

6.03e-108571462025609649
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

VPS18 TRIM25 USP25 HMOX1 ATG2A MFN1 EPG5 ATM WDFY3 VCP

8.82e-101501461032423001
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

WASHC4 SMC1A PATL1 IDE CPS1 PAPSS2 GTF3C3 DHX30 RTKN2 PPP2R1B TLK1 CNOT6L CEP72 CCDC15 ATM HERC2 ZW10 RPA3 DYNC1LI2 VCP

8.75e-0811551462020360068
Pubmed

Defining the membrane proteome of NK cells.

ERAP1 DOCK8 FARSB PSMC5 RNF213 MSH3 HEATR1 API5 PARP4 PTPRC PIGA PIK3C2A NBEAL2 SCARB2 NCAPD2 NCEH1 HERC2 ZW10 DDX24 DYNC1LI2

1.05e-0711681462019946888
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ATP6V1B2 WASHC4 SMC1A USP25 NAP1L3 MSH3 USP9Y RYR3 DHX30 ARG2 PTPRD MORF4L2 USP7 CCDC15 ATM WDFY3 HERC2 PC MNAT1 RECK VCP

1.06e-0712851462135914814
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

TRIM25 FARSB PSMC5 RNF213 HEATR1 RFC1 ARG2 PPP2R1B IARS2 CNOT6L METTL9 PIK3C2A AASS SCARB2 NCAPD2 USP7 ATM ZW10 DDX24 RPA3 VPS53 VCP

1.64e-0714401462230833792
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SMC1A PSMC5 HEATR1 USH1C DHX30 POSTN SLIT2 DZANK1 TLK1 CNOT6L METTL9 WDR35 SNX27 ZW10 DDX24 RPA3 CAMSAP2 VPS53 DYNC1LI2 TP53BP2 SORL1

1.68e-0713211462127173435
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

TRIM25 WASHC4 SMC1A FARSB PSMC5 MSH3 HEATR1 RFC1 PAPSS2 GTF3C3 DHX30 SUGP2 PIK3C2A NCAPD2 USP7 SNX27 WDFY3 HERC2 DDX24 VCP TP53BP2

2.49e-0713531462129467282
Pubmed

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.

ANKRD13D EPHX1 LETMD1 USP25 RNF213 RFC1 MORC2 GTF3C3 PPP2R1B USP7 HERC2 MNAT1 VCP TP53BP2

2.89e-076041461438803224
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

TRIM25 WASHC4 FARSB PSMC5 MSH3 HEATR1 CPS1 MORC2 DHX30 IARS2 LIMS1 SUGP2 SNX27 PC DDX24

3.11e-077041461529955894
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

GRM4 GRM8 RYR3 PTPRD PTPRE KCNH1 UNC5C RPA3

6.86e-07171146820201926
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

ANKRD13D HSPG2 USP25 PSMC5 RNF213 RFC1 NFIA SLMAP SNX27 HERC2 MNAT1 VCP

9.87e-074811461228190767
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

VPS18 SMC1A RNF213 MORC2 PARP4 TLK1 NFIA FIG4 CEP72 WDR35 NCEH1 PDZRN4

1.28e-064931461215368895
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

TRIM25 SMC1A FARSB RNF213 MSH3 API5 RFC1 MORC2 GTF3C3 SUGP2 NCAPD2 USP7 UBE2S ATM RPA3 MNAT1 VCP

1.36e-0610141461732416067
Pubmed

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.

MSH3 ATM DNMT3A DNMT3B

1.37e-0620146426023099
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

SMC1A MSH3 RFC1 USP9Y PIK3C2A HERC2

1.88e-0687146617148452
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

VPS18 SMC1A PSMC5 HEATR1 PAPSS2 GTF3C3 MALT1 TLK1 LIMS1 CNOT6L MORF4L2 SLMAP USP7 HERC2 ZW10 DDX24 RPA3 MNAT1 VCP

1.98e-0612841461917353931
Pubmed

Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.

PTPRC PTPRD PTPRE

2.51e-067146312376545
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

TNC DNAH2 NAP1L3 FARSB IDE RFC1 OR52P1 PARP4 NFIA CEP72 AASS UNC5C WDFY3

3.23e-066381461331182584
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PSMC5 HEATR1 RFC1 GTF3C3 DHX30 IARS2 SUGP2 NCAPD2 USP7 ATM HERC2 DDX24 VCP

4.15e-066531461322586326
Pubmed

Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.

HMOX1 HMCN1 CNDP1

5.98e-069146320299368
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

RFC1 OVCH1 DHX30 SLIT2 USP7 CAMSAP1 PC DDX24

7.07e-06234146836243803
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

ATP6V1B2 TRIM25 PSMC5 GTF3C3 DHX30 SLIT2 IARS2 ATM HERC2

7.59e-06313146938270169
Pubmed

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.

SMC1A MSH3 RFC1 ATM

8.59e-0631146426095369
Pubmed

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).

TRIM25 DHX30 USP7 DDX24

8.59e-0631146426678539
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

EPHX1 TRIM25 DNAH10 SMC1A FARSB PSMC5 MSH3 HEATR1 IDE API5 RFC1 GTF3C3 DHX30 IARS2 NCAPD2 USP7 ATM PC DDX24

8.80e-0614251461930948266
Pubmed

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

TRIM25 PSMC5 DHX30 USP7 VCP

9.53e-0667146529357390
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

SMC1A MSH3 RFC1 MORC2 GTF3C3 FSIP2 NFIA MORF4L2 USP7 HERC2 DDX24 DNMT3A

1.07e-056081461236089195
Pubmed

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.

SMC1A RFC1 ATM

1.17e-0511146311877377
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

TRIM25 SMC1A FARSB PSMC5 RNF213 MSH3 NCAPD2 USP7 SNX27

1.21e-05332146932786267
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

EPHX1 LETMD1 FBLL1 SMC1A USP9Y GTF3C3 DHX30 SUGP2 MORF4L2 USP7 ATM DDX24 DYNC1LI2 VCP DNMT3A DNMT3B

1.36e-0510821461638697112
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

PSMC5 RNF213 HEATR1 PATL1 GTF3C3 LIMS1 ATM VCP

1.60e-05262146836880596
Pubmed

Network organization of the human autophagy system.

VPS18 SMC1A FARSB PSMC5 ATG2A GTF3C3 PIK3C2A USP7 RPA3 TP53BP2

1.72e-054371461020562859
Pubmed

Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b.

DNMT3A DNMT3B

1.75e-052146212869530
Pubmed

Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase.

DNMT3A DNMT3B

1.75e-052146226098813
Pubmed

The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin.

DNMT3A DNMT3B

1.75e-052146215456878
Pubmed

Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.

ERAP1 ERAP2

1.75e-052146218393273
Pubmed

Liver-specific deletion of de novo DNA methyltransferases protects against glucose intolerance in high-fat diet-fed male mice.

DNMT3A DNMT3B

1.75e-052146238795327
Pubmed

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

DNMT3A DNMT3B

1.75e-052146219620278
Pubmed

Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.

DNMT3A DNMT3B

1.75e-052146215757890
Pubmed

Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.

DNMT3A DNMT3B

1.75e-052146233846253
Pubmed

DNA methylation and demethylation in mammals.

DNMT3A DNMT3B

1.75e-052146221454628
Pubmed

Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome.

DNMT3A DNMT3B

1.75e-052146215854647
Pubmed

DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro.

DNMT3A DNMT3B

1.75e-052146227468168
Pubmed

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.

DNMT3A DNMT3B

1.75e-052146217890317
Pubmed

Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.

ERAP1 ERAP2

1.75e-052146223545452
Pubmed

The influence of DNMT3A and DNMT3B gene polymorphisms on acute myeloid leukemia risk in a Moroccan population.

DNMT3A DNMT3B

1.75e-052146232912818
Pubmed

Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.

DNMT3A DNMT3B

1.75e-052146216501171
Pubmed

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.

DNMT3A DNMT3B

1.75e-052146225639876
Pubmed

Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population.

ERAP1 ERAP2

1.75e-052146232321463
Pubmed

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.

ERAP1 ERAP2

1.75e-052146230215709
Pubmed

Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases.

DNMT3A DNMT3B

1.75e-052146211919202
Pubmed

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.

ERAP1 ERAP2

1.75e-052146212436110
Pubmed

An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.

ERAP1 ERAP2

1.75e-052146212436109
Pubmed

ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.

ERAP1 ERAP2

1.75e-052146230794838
Pubmed

The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1.

HMOX1 USP7

1.75e-052146235821281
Pubmed

Epigenetic inheritance is unfaithful at intermediately methylated CpG sites.

DNMT3A DNMT3B

1.75e-052146237660134
Pubmed

Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow Hematopoiesis.

PTPRC KIT

1.75e-052146226389592
Pubmed

De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state.

DNMT3A DNMT3B

1.75e-052146221576263
Pubmed

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.

ATP6V1B2 KCNH1

1.75e-052146225915598
Pubmed

A new assay method for late CFU-S formation and long-term reconstituting activity using a small number of pluripotent hemopoietic stem cells.

PTPRC KIT

1.75e-052146212004082
Pubmed

Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.

ERAP1 ERAP2

1.75e-052146220843824
Pubmed

Dissect the DNMT3A- and DNMT3B-mediated DNA Co-methylation through a Covalent Complex Approach.

DNMT3A DNMT3B

1.75e-052146231726062
Pubmed

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

DOCK8 HMOX1

1.75e-052146227798618
Pubmed

Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.

DNMT3A DNMT3B

1.75e-052146232968275
Pubmed

Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.

DNMT3A DNMT3B

1.75e-052146230258352
Pubmed

Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.

DNMT3A DNMT3B

1.75e-052146212897133
Pubmed

C-kit+ CD45- cells found in the adult human heart represent a population of endothelial progenitor cells.

PTPRC KIT

1.75e-052146220119835
Pubmed

ERAP1-ERAP2 dimerization increases peptide-trimming efficiency.

ERAP1 ERAP2

1.75e-052146224928998
Pubmed

Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.

ERAP1 ERAP2

1.75e-052146220419298
Pubmed

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.

DNMT3A DNMT3B

1.75e-052146232620778
Pubmed

Centromere mitotic recombination in mammalian cells.

DNMT3A DNMT3B

1.75e-052146218541703
Pubmed

Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture.

TNC POSTN

1.75e-052146219887451
Pubmed

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.

DNMT3A DNMT3B

1.75e-052146210555141
Pubmed

DNA methyltransferase 3A promoter polymorphism is associated with the risk of human spontaneous abortion after assisted reproduction techniques and natural conception.

DNMT3A DNMT3B

1.75e-052146227817038
Pubmed

Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines.

ERAP1 ERAP2

1.75e-052146216585582
Pubmed

Hidden Markov Modelling Reveals Neighborhood Dependence of Dnmt3a and 3b Activity.

DNMT3A DNMT3B

1.75e-052146231027045
Pubmed

A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA.

DNMT3A DNMT3B

1.75e-052146220507910
Pubmed

Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes.

DNMT3A DNMT3B

1.75e-052146223611774
Pubmed

Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.

DNMT3A DNMT3B

1.75e-052146232581223
Pubmed

Chromatin targeting of de novo DNA methyltransferases by the PWWP domain.

DNMT3A DNMT3B

1.75e-052146214998998
Pubmed

Association of DNA methyltransferases 3A and 3B polymorphisms, and plasma folate levels with the risk of urothelial carcinoma.

DNMT3A DNMT3B

1.75e-052146225126948
Pubmed

Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.

ERAP1 ERAP2

1.75e-052146219433412
Pubmed

The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.

ERAP1 ERAP2

1.75e-052146222106953
Pubmed

Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.

ERAP1 ERAP2

1.75e-052146215908954
Pubmed

Analysis of differentially expressed genes and microRNAs in alcoholic liver disease.

FZD5 ACSF3

1.75e-052146223337955
Pubmed

Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse.

DNMT3A DNMT3B

1.75e-052146216725135
Pubmed

Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.

DNMT3A DNMT3B

1.75e-052146221304883
Pubmed

Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B.

DNMT3A DNMT3B

1.75e-052146226993463
Pubmed

DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation.

DNMT3A DNMT3B

1.75e-052146212370304
Pubmed

Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence.

ERAP1 ERAP2

1.75e-052146233309189
Pubmed

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

ERAP1 ERAP2

1.75e-052146229108111
Pubmed

Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population.

EPHX1 HMOX1

1.75e-052146217203192
Pubmed

Expression and potential role of microRNA-29b in mouse early embryo development.

DNMT3A DNMT3B

1.75e-052146225766529
Pubmed

CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.

CAMSAP1 CAMSAP2

1.75e-052146234019079
Pubmed

The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset.

ERAP1 ERAP2

1.75e-052146229183862
Pubmed

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases.

DNMT3A DNMT3B

1.75e-05214629662389
Pubmed

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes.

ERAP1 ERAP2

1.75e-052146229991817
Pubmed

Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation.

DNMT3A DNMT3B

1.75e-052146217579209
Pubmed

Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.

ERAP1 ERAP2

1.75e-052146228063628
InteractionEDEM1 interactions

VPS18 TRIM25 USP25 HMOX1 ATG2A MFN1 EPG5 NCEH1 ATM WDFY3 VCP

2.29e-0720214411int:EDEM1
InteractionGPR17 interactions

WASHC4 ERAP1 RNF213 HEATR1 HMOX1 MFN1 NCAPD2 ATM WDFY3 ZW10 VPS53

6.18e-0628314411int:GPR17
InteractionBSG interactions

TRIM25 DOCK8 RNF213 HEATR1 API5 PPP2R1B NBEAL2 SCARB2 NCAPD2 USP7 ATM WDFY3 ZW10 RPA3 VPS53 VCP

1.19e-0563114416int:BSG
Cytoband15q14-q15

VPS18 RYR3

9.98e-055146215q14-q15
GeneFamilyAminopeptidases|CD molecules

ERAP1 ERAP2 ENPEP

1.06e-04171003104
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRC PTPRD PTPRE

2.03e-04211003813
GeneFamilyCohesin complex

SMC1A STAG3

8.30e-04810021060
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM4 GRM8

8.30e-0481002281
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEAL2 WDFY3

1.06e-03910021230
GeneFamilyReceptor Tyrosine Kinases|CD molecules

PTK7 MST1R KIT

1.40e-03401003321
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 PTK7 PTPRD HMCN1 UNC5C

2.01e-031611005593
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

ERAP1 HEATR1 USP9Y

2.82e-03511003870
GeneFamilyAAA ATPases

PSMC5 RFC1 VCP

3.15e-03531003413
GeneFamilyUbiquitin specific peptidases

USP25 USP9Y USP7

3.68e-03561003366
GeneFamilyDyneins, axonemal

DNAH10 DNAH2

3.90e-03171002536
GeneFamilyEF-hand domain containing|Nucleotide excision repair|Transcription and export complex 2

RPA3 MNAT1

4.37e-031810021269
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

PPP2R1B SLMAP

5.39e-032010021371
GeneFamilyPWWP domain containing

DNMT3A DNMT3B

6.51e-032210021147
CoexpressionGSE22935_24H_VS_48H_MBOVIS_BCG_STIM_MACROPHAGE_UP

TRIM25 USP25 GRM4 PAPSS2 PPP2R1B KIT CAMSAP2 VCP

1.71e-052001468M7776
CoexpressionGSE38681_WT_VS_LYL1_KO_LYMPHOID_PRIMED_MULTIPOTENT_PROGENITOR_DN

TRIM25 MAP3K8 USP25 PIGA PTPRE PIK3C2A SCARB2 DDX24

1.71e-052001468M9020
CoexpressionKUMAR_TARGETS_OF_MLL_AF9_FUSION

EPHX1 LGR5 ARG2 POSTN IARS2 LIMS1 METTL9 ATM VPS53 ENPEP RECK

1.90e-0540814611M3284
CoexpressionCARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_HYPOMETHYLATED_AND_UP

HSPG2 TNC LGR5 PTK7 NCAPD2 KIT DNMT3A

3.57e-051621467M45037
CoexpressionGSE7568_IL4_VS_IL4_AND_TGFB_TREATED_MACROPHAGE_24H_UP

EPHX1 USP25 TBC1D8B PTPRE SCARB2 NCAPD2 SORL1

4.34e-051671467M365
CoexpressionKUMAR_TARGETS_OF_MLL_AF9_FUSION

EPHX1 LGR5 ARG2 POSTN IARS2 LIMS1 METTL9 ATM VPS53 ENPEP RECK

5.99e-0546314611MM1011
CoexpressionFISCHER_DREAM_TARGETS

MCM8 SMC1A MSH3 HEATR1 PATL1 RFC1 RTKN2 PIGA CEP72 NCAPD2 CCDC15 UBE2S ZW10 THAP12 PRIMPOL DNMT3B

1.05e-0496914616M149
CoexpressionRASHI_RESPONSE_TO_IONIZING_RADIATION_5

CNOT6L NFIA SLMAP USP7 HERC2 DNMT3A

1.08e-041341466M15659
CoexpressionGSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP

SMC1A MORC2 GTF3C3 DHX30 MALT1 TLK1 NAXD

1.11e-041941467M6103
CoexpressionGSE28783_ANTI_MIR33_VS_UNTREATED_ATHEROSCLEROSIS_MACROPHAGE_DN

TRIM25 IDE RFC1 ATP10D WDFY3 MNAT1 TP53BP2

1.30e-041991467M8352
CoexpressionGSE25123_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_DAY10_DN

MEP1A SUGP2 NFIA MORF4L2 SLC16A14 ENPEP RASAL1

1.30e-041991467M7965
CoexpressionGSE8515_CTRL_VS_IL1_4H_STIM_MAC_UP

LETMD1 SLIT2 ZW10 CFAP44 VPS53 RASAL1 PDZRN4

1.30e-041991467M5759
CoexpressionGSE9650_NAIVE_VS_EFF_CD8_TCELL_UP

EPHX1 MFN1 DHX30 METTL9 MORF4L2 CAMSAP1 KIT

1.34e-042001467M5819
CoexpressionGSE8685_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_DN

ANKRD13D GRM4 ARG2 DNAJB13 DDX24 CAMSAP2 ENPEP

1.34e-042001467M330
CoexpressionGSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_16H_DN

EPHX1 CPS1 NALCN SCARB2 VPS53 CDH16 SORL1

1.34e-042001467M8267
CoexpressionGSE43863_TH1_VS_LY6C_INT_CXCR5POS_EFFECTOR_CD4_TCELL_DN

ANKRD13D EPHX1 ATP10D PARP4 PTPRC SCARB2 HERC2

1.34e-042001467M9765
CoexpressionGSE21670_STAT3_KO_VS_WT_CD4_TCELL_TGFB_IL6_TREATED_DN

EPHX1 ATP10D PARP4 TLK1 NCEH1 CAMSAP2 SORL1

1.34e-042001467M7453
CoexpressionGSE8921_UNSTIM_0H_VS_TLR1_2_STIM_MONOCYTE_6H_DN

GLB1L3 DZANK1 PIK3C2A ODR4 RECK TP53BP2 CNDP1

1.34e-042001467M6404
CoexpressionGSE3982_BASOPHIL_VS_TH2_UP

WASHC4 ATP10D PARP4 PTPRE PIK3C2A FIG4 KIT

1.34e-042001467M5566
CoexpressionGSE22886_IGA_VS_IGM_MEMORY_BCELL_DN

MAP3K8 HMOX1 FIG4 FZD5 INTS9 WDFY3 HERC2

1.34e-042001467M4439
CoexpressionAtlasDevelopingKidney_e15.5_Proximal Tubules_emap-28005_top-relative-expression-ranked_1000

AADAC NUDT7 WASHC4 GRM4 USH1C ATP10D RYR3 MEP1A AGXT2 PIK3C2A FZD5 NBEAL2 NCEH1 PC CAMSAP2 ENPEP PRIMPOL CDH16 SORL1 CNDP1

2.33e-0775814520gudmap_developingKidney_e15.5_Proximal Tubules_1000
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_top-relative-expression-ranked_1000

EPHX1 WASHC4 TNC SMC1A PAPSS2 ARG2 POSTN SLIT2 CNOT6L NALCN NFIA NRK WDR35 SNX27 WDFY3 ENPEP CDH16 DNMT3A CNDP1

2.17e-0679714519gudmap_developingGonad_P2_epididymis_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_1000

MSH3 HEATR1 RFC1 LIMS1 PIK3C2A NFIA NRK USP7 SNX27 HERC2 KIT VCP DNMT3A

3.49e-0639714513gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000_k5
CoexpressionAtlasdev gonad_e12.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000

MCM8 TNC RNF213 P4HA3 PAPSS2 LGR5 POSTN SLIT2 PTPRD HMCN1 NFIA KCNH1 NRK SCARB2 UNC5C ENPEP RECK DNMT3A

8.05e-0679314518gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_1000
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_top-relative-expression-ranked_1000

TRIM25 WASHC4 SMC1A IDE RFC1 PAPSS2 LGR5 MEP1A ARG2 AGXT2 PTPRC CNOT6L FZD5 SLMAP ATM CAMTA1 ENPEP

1.80e-0576114517gudmap_developingKidney_e14.5 whole kidney - wildtype_emap-6674_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000

TNC RNF213 PAPSS2 TBC1D8B LGR5 POSTN SLIT2 PTPRD HMCN1 NFIA KCNH1 NRK UNC5C NCAPD2 ENPEP RECK DNMT3A

2.02e-0576814517gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000

TNC POSTN SLIT2 PTPRD HMCN1 NFIA NRK UNC5C WDR35 RECK DNMT3A

2.09e-0533714511gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k1_1000
CoexpressionAtlasDevelopingKidney_e15.5_Proximal Tubules_emap-28005_k-means-cluster#5_top-relative-expression-ranked_1000

AADAC GRM4 ATP10D RYR3 MEP1A AGXT2 FZD5 NCEH1 ENPEP CNDP1

2.34e-0528014510gudmap_developingKidney_e15.5_Proximal Tubules_1000_k5
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#2_top-relative-expression-ranked_1000

WASHC4 TNC PAPSS2 ARG2 POSTN NALCN ENPEP CDH16 CNDP1

2.97e-052301459gudmap_developingGonad_P2_epididymis_1000_k2
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_top-relative-expression-ranked_1000

MSH3 IDE RFC1 DHX30 ARG2 SLIT2 TLK1 PIK3C2A NBEAL2 USP7 UBE2S CAMSAP2 CDH16 DNMT3A SORL1 DNMT3B CNDP1

3.43e-0580114517gudmap_developingKidney_e15.5_ureter tip_1000_flank cortic collct
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

SMC1A PSMC5 RNF213 RFC1 LGR5 SLIT2 CNOT6L PTPRE NFIA KCNH1 NRK USP7 SNX27 WDFY3 STAG3 CDH16 DNMT3A

3.71e-0580614517gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

TNC TBC1D8B POSTN SLIT2 PTPRD HMCN1 NRK UNC5C ENPEP RECK

5.52e-0531014510gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000

NUDT7 WASHC4 DOCK8 MSH3 IDE PAPSS2 MEP1A ARG2 LIMS1 PIK3C2A UBE2S NCEH1 CAMSAP2 CDH16 SORL1 PDZRN4

1.10e-0479514516gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
CoexpressionAtlaskidney_adult_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

EPHX1 AADAC DOCK8 USH1C PAPSS2 MEP1A NDST3 AGXT2 AASS SLC16A14 NCEH1 WDFY3 PC ENPEP CDH16 SORL1

1.17e-0479914516gudmap_kidney_adult_JuxtaGlom_Ren1_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#1_top-relative-expression-ranked_1000

IDE MEP1A PIK3C2A NFIA HERC2 CAMSAP2 CDH16

1.90e-041731457gudmap_developingLowerUrinaryTract_e15.5_Urothelium_1000_k1
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#4_top-relative-expression-ranked_500

SLIT2 CNOT6L NALCN USP7 WDFY3 CDH16 DNMT3A

2.04e-041751457gudmap_developingGonad_e14.5_ epididymis_500_k4
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

EPHX1 RNF213 P4HA3 TBC1D8B POSTN SLIT2 HMCN1 NFIA NRK UNC5C NCAPD2 KIT ENPEP RECK DNMT3A

2.69e-0477314515gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_1000

NUDT7 DOCK8 MSH3 IDE PIK3C2A UBE2S NCEH1 CAMSAP2 SORL1 PDZRN4

2.84e-0437914510gudmap_developingKidney_e15.5_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

IDE LIMS1 PIK3C2A NFIA NRK USP7 HERC2 CAMSAP1 CAMSAP2 VCP

3.22e-0438514510gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_top-relative-expression-ranked_500

TRIM25 RFC1 PAPSS2 LGR5 MEP1A ARG2 AGXT2 FZD5 ATM ENPEP

3.22e-0438514510gudmap_developingKidney_e14.5 whole kidney - wildtype_emap-6674_500
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_500

NUDT7 WASHC4 MSH3 IDE ARG2 PIK3C2A CAMSAP2 CDH16 SORL1 CNDP1

3.56e-0439014510gudmap_developingKidney_e15.5_cortic collect duct_500
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000

WASHC4 SMC1A SLIT2 CNOT6L NALCN NFIA NRK USP7 WDR35 SNX27 WDFY3 ENPEP CDH16 DNMT3A CNDP1

3.82e-0479914515gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#4_top-relative-expression-ranked_1000

WASHC4 SMC1A CNOT6L NALCN NFIA WDFY3 CDH16 DNMT3A

3.85e-042561458gudmap_developingGonad_e14.5_ epididymis_1000_k4
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000

USP25 NAP1L3 SLIT2 CNOT6L USP7 SNX27 WDFY3 CDH16 DNMT3A

3.87e-043231459gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000

SMC1A SLIT2 CNOT6L USP7 SNX27 WDFY3 CDH16 DNMT3A

4.16e-042591458gudmap_developingGonad_e12.5_epididymis_k3_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#4_top-relative-expression-ranked_500

TNC P4HA3 POSTN NRK UNC5C

4.45e-04931455gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k4_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_1000

MSH3 HEATR1 RFC1 SLIT2 LIMS1 PTPRD PIK3C2A NFIA NRK USP7 SNX27 HERC2 KIT VCP DNMT3A

4.46e-0481114515gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_500

NUDT7 DOCK8 MSH3 IDE UBE2S NCEH1 CAMSAP2 CDH16 SORL1 PDZRN4

4.52e-0440214510gudmap_developingKidney_e15.5_anlage of loop of Henle_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000

MSH3 IDE PIK3C2A NFIA NRK USP7 HERC2 CAMSAP2 VCP

4.52e-043301459DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_200

RNF213 LGR5 POSTN HMCN1 NFIA NRK

4.53e-041431456gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_200
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_500

NUDT7 DOCK8 MSH3 IDE UBE2S NCEH1 CAMSAP2

4.71e-042011457gudmap_developingKidney_e15.5_500_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000

TNC NAP1L3 MSH3 IDE RYR3 DZANK1 CNOT6L NALCN PIK3C2A NFIA NRK USP7 HERC2 CAMSAP2 VCP

4.88e-0481814515DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#3_top-relative-expression-ranked_1000

P4HA3 TBC1D8B POSTN SLIT2 HMCN1 NRK UNC5C ENPEP RECK

5.15e-043361459gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k3_1000
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000

MSH3 IDE RFC1 TLK1 PIK3C2A USP7 UBE2S CAMSAP2 DNMT3B

5.49e-043391459gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500

SLIT2 CNOT6L NALCN NFIA NRK USP7 SNX27 WDFY3 CDH16 DNMT3A

5.57e-0441314510gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#5_top-relative-expression-ranked_1000

MSH3 IDE PAPSS2 PIK3C2A NCEH1 CAMSAP2

6.26e-041521456gudmap_developingKidney_e15.5_S-shaped body_1000_k5
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EPHX1 DNAH10 TNC DNAH2 NFIA CFAP221 VWA3B CFAP44

2.52e-071931468ea345d34440b25f65358a53dc72831998d1c3620
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH10 DNAH2 AK7 DNAJB13 DZANK1 CFAP221 VWA3B CFAP44

2.73e-07195146860067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 CPS1 RYR3 HMCN1 AASS UNC5C PDZRN4

1.01e-061601467c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 CPS1 RYR3 HMCN1 AASS UNC5C PDZRN4

1.01e-06160146725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TNC NAP1L3 ATP10D PTK7 POSTN HMCN1 UNC5C

1.91e-0617614679bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TNC NAP1L3 ATP10D PTK7 POSTN HMCN1 UNC5C

1.91e-0617614673f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 GRM4 GRM8 RYR3 PTK7 NFIA PDZRN4

1.91e-061761467e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM4 GRM8 RYR3 PTK7 PPP2R1B RASAL1 PDZRN4

1.98e-06177146757033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCelldroplet-Kidney|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC PAPSS2 MEP1A AASS NCEH1 PC CDH16

2.22e-0618014677e5f497699876ac8e1ce780626c6f5a1f6f5f079
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 ATP10D RYR3 EPG5 HMCN1 CEP72 DNMT3B

2.47e-061831467919c9861073d12fd12aecd7469b1478b13838c43
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

ATP10D SLIT2 HMCN1 NALCN NRK KIT RECK

2.56e-06184146767164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

2.66e-0618514675e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 USH1C MALT1 PTPRD NFIA WDFY3 ENPEP

2.85e-0618714679d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

3.64e-061941467756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

3.64e-0619414671ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

3.76e-0619514673486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

3.76e-061951467e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellfacs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX1 TNC LGR5 POSTN PPP2R1B HMCN1 PDZRN4

3.89e-06196146790edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCellPND10-Mesenchymal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TNC POSTN SLIT2 PTPRD HMCN1 NFIA ENPEP

3.89e-061961467ace167a40adb7022b365be3c2b1cbd4ba963739a
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

TNC PTK7 POSTN SLIT2 PTPRD HMCN1 UNC5C

4.02e-061971467f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellwk_20-22-Epithelial-Proximal_epithelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

4.16e-06198146716c54b884500066ade05a406915f9569ca8abdfc
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

DNAH10 DNAJB13 DZANK1 CFAP221 WDR35 VWA3B CFAP44

4.16e-0619814676d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellmedial-Epithelial-Ciliated-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

4.30e-061991467526002f16bbf61cf086278d45a401cc0b0b757a8
ToppCellmedial-Epithelial-Ciliated|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

4.30e-061991467a2daa42b100c422dc8c04fb7d2ebf54293eef574
ToppCellmedial-2-Epithelial-Ciliated|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

4.30e-061991467c02f04a5aa79ee0cf427f6e94b93ceab38ebbcd7
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

4.44e-06200146731d75c26055177d656df1fbb10b764cebd61e122
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO-|Neuronal / cells hierarchy compared to all cells using T-Statistic

MAP3K8 GRM4 GRM8 RYR3 PTK7 NFIA PDZRN4

4.44e-062001467e3051dcf9b5c8e4dc71a8080b7a7aafea46f2b2b
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO--|Neuronal / cells hierarchy compared to all cells using T-Statistic

MAP3K8 GRM4 GRM8 RYR3 PTK7 NFIA PDZRN4

4.44e-0620014671ce9599cc9d8158e8842ca56f35fa7809c234849
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DNAH10 DNAH2 AK7 DZANK1 CFAP221 VWA3B CFAP44

4.44e-0620014674992dbf0514d674017315dbd20d91dfec0c608e9
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B CFAP44

4.44e-062001467e1dce91c6c531bb212002a14705e496d77ad3490
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO---L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

MAP3K8 GRM4 GRM8 RYR3 PTK7 NFIA PDZRN4

4.44e-0620014677b845aabfbdfe893acc9334a5707833761bed60b
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO|Neuronal / cells hierarchy compared to all cells using T-Statistic

MAP3K8 GRM4 GRM8 RYR3 PTK7 NFIA PDZRN4

4.44e-0620014670638273fc0910f47fe7a0b6d9a8639b0e9976d13
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8|TCGA-Thymus / Sample_Type by Project: Shred V9

P4HA3 LGR5 SLIT2 HMCN1 NRK PDZRN4

1.07e-0515114665906562efd36fbcb91f96e0a0d3a8fe999ba1e79
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

1.19e-0515414664e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

1.19e-0515414667556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-Activated_CD8_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK8 RNF213 PTPRC CNOT6L PIGA MNAT1

1.70e-05164146624fdea5113d92b96f56b06dd2449910a3c785e69
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USH1C AGXT2 KCNH6 SLIT2 PTPRD ENPEP

1.95e-051681466fa0d251693935116adf633d02b7ec4a295100865
ToppCellfacs-Kidney|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC USH1C MEP1A PTPRC AASS CDH16

1.95e-051681466d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 GRM4 RYR3 PTK7 NFIA PDZRN4

1.95e-0516814667abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 RYR3 PTK7 NFIA IQCF3 PDZRN4

2.09e-051701466417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

RNF213 PTPRC CNOT6L ATM DDX24 ENPEP

2.16e-0517114662e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

AADAC LGR5 MST1R HMCN1 NCAPD2 CCDC15

2.23e-051721466c6bc78fd63c9479a84ec0552b55c89750cad0fa5
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

AADAC LGR5 MST1R HMCN1 NCAPD2 CCDC15

2.23e-051721466bfb87a281a9cf6ad45b310bf8104fc0ab382b549
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 RYR3 PTK7 NFIA IQCF3 PDZRN4

2.38e-051741466e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 GRM4 GRM8 RYR3 PTK7 PDZRN4

2.46e-05175146690e29945aa861082c94bb4f331161adc3a6ef899
ToppCell3'_v3-blood-Mast-Mast_cells|blood / Manually curated celltypes from each tissue

MORC2 ATP10D RYR3 KIT PRIMPOL DNMT3B

2.54e-051761466b9da3deaf62622d47eb30b6be7548253eee95597
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 GRM4 GRM8 RYR3 PTK7 PDZRN4

2.62e-051771466bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

USP9Y PTK7 HMCN1 UNC5C CDH16 SORL1

2.62e-051771466c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 GRM4 GRM8 RYR3 PTK7 PDZRN4

2.79e-0517914667954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 GRM4 RYR3 PTK7 NFIA PDZRN4

2.79e-051791466f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 DNAH2 DNAJB13 DZANK1 VWA3B CFAP44

2.88e-05180146692fb01b91261b3103454924cde56add337b41844
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TNC SLIT2 PTPRD HMCN1 UNC5C ENPEP

2.97e-0518114669ede19228ba5c0668a9c06c915510b95585216ef
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HSPG2 GRM4 RTKN2 FZD5 NCEH1 TP53BP2

3.06e-051821466573771130247e869e4e58f22d4a1cb31989635cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USH1C AGXT2 KCNH6 PTPRD PC ENPEP

3.06e-0518214664a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC PAPSS2 MEP1A AASS PC CDH16

3.06e-051821466faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HSPG2 GRM4 RTKN2 FZD5 NCEH1 TP53BP2

3.06e-0518214666cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC PAPSS2 MEP1A AASS PC CDH16

3.06e-051821466be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCellnormal-na-Lymphocytic_T-CytoT_GZMK+-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

MAP3K8 RNF213 ATG2A PTPRC CNOT6L ATM

3.16e-05183146679defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAP3K8 GRM4 RYR3 PTK7 NFIA PDZRN4

3.16e-05183146665f2a5895d166189a095cf7ea9dda171f0419b08
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 CPS1 RYR3 PTPRD HMCN1 NRK

3.25e-0518414662cbed6462fea2622871bb7e49b0df3d984239281
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

TNC P4HA3 PTK7 POSTN PTPRD HMCN1

3.25e-0518414660b336489c10e8c3c957795dd845454f03404382b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 CPS1 RYR3 PTPRD HMCN1 NRK

3.25e-051841466ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 CPS1 RYR3 PTPRD HMCN1 NRK

3.25e-0518414662b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|368C / Donor, Lineage, Cell class and subclass (all cells)

AASDH IDE MORC2 ATP10D ACSF3 RPA3

3.25e-051841466d48807f9da48bdd015a54c606d2e2a311f181396
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAH2 AK7 CFAP221 VWA3B CFAP44

3.46e-05186146676033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMOX1 USH1C AGXT2 SLIT2 PTPRD ENPEP

3.46e-0518614668287146f0ba415ea04475588117d4668ae00f75c
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

3.46e-05186146685787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

IDE LGR5 PARP4 HMCN1 PIK3C2A SLMAP

3.46e-05186146603db813598b67b1e08f759758a1c2023396921fa
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TNC RYR3 MST1R PTPRD KCNH1 NRK

3.56e-0518714665258674d0346e5c51a4b965efcdc1790c970845d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMOX1 USH1C AGXT2 SLIT2 PTPRD ENPEP

3.56e-05187146671eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

DOCK8 USH1C AGXT2 MALT1 PTPRD ENPEP

3.56e-051871466d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellE16.5-samps-Mesenchymal|E16.5-samps / Age Group, Lineage, Cell class and subclass

TNC SLIT2 PTPRD NFIA UNC5C ENPEP

3.67e-0518814663f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC AASS SLC16A14 UNC5C PC CDH16

3.67e-051881466b483b4629695764568bcbd1d527d614824147783
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC AASS SLC16A14 UNC5C PC CDH16

3.67e-051881466c1f64311ff05093b2f4f672e33f5f75e3bc8a8db
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNC PTK7 SLIT2 PTPRD UNC5C ENPEP

3.78e-05189146632e6d6285b258831b965281224ff2aaeecdcb5f5
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

PTK7 SLIT2 PTPRD HMCN1 UNC5C ENPEP

3.78e-051891466dc5164591dea45b420798b94dda211be03daa70c
ToppCellMacrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ERAP1 DOCK8 OVCH1 PTPRC ERAP2 NCEH1

3.78e-051891466c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

3.78e-051891466a3cd4c2da4feb9bdcd8957f3e344d095da1367b8
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

USH1C AGXT2 MALT1 PTPRD NFIA ENPEP

3.78e-0518914660be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH10 DNAH2 AK7 CFAP221 VWA3B CFAP44

3.78e-0518914663e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNC PTK7 SLIT2 PTPRD UNC5C ENPEP

3.78e-051891466385ef7bbd76c8047aeecf6542377d4213b5da5db
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

3.78e-05189146693b1026bb1ba759e5704561c9a5de14a30c08894
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC TLK1 IARS2 LIMS1 FZD5 USP7

3.89e-05190146636e83995021ba16690f84e2077a9e8baec547d05
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

PTK7 SLIT2 PTPRD HMCN1 UNC5C ENPEP

3.89e-0519014661196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TNC SLIT2 NFIA NRK UNC5C ENPEP

3.89e-0519014667986586b7c82e91c71102cc8c4d7a689ae63ab4d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNC SLIT2 HMCN1 NALCN KCNH1 PDZRN4

3.89e-051901466562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellcellseq2-Epithelial-Epithelial_Airway|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

3.89e-05190146617829f4de31b3d9e4d71ba4817d18842aa699773
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNC SLIT2 HMCN1 NALCN KCNH1 PDZRN4

3.89e-051901466f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AADAC TLK1 IARS2 LIMS1 FZD5 USP7

3.89e-051901466d26be9e1b676f750e716b91ebc3598fac3735612
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-0519114667b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-0519114662a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-05191146646c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-0519114669f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

PTK7 SLIT2 PTPRD NFIA UNC5C ENPEP

4.01e-0519114663379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-051911466fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellHealthy_Control-Epithelial-Epithelial-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-05191146628caedb2e448e0c7f494100d714fa7cdcf150691
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-051911466b4e335e798c9617356b8e24412f9270c42dce656
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-051911466c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-051911466995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH10 DNAH2 AK7 DNAJB13 CFAP221 VWA3B

4.01e-0519114665129f778a9283bfac4ff322c21c5ca71da4b7174
Drug9,10-Dimethyl-1,2-benzanthracene

ANKRD13D EPHX1 HSPG2 TNC USP25 IDE HMOX1 PAPSS2 MFN1 ARG2 SLIT2 MALT1 PPP2R1B CNOT6L PIGA PTPRD NAXD ATM KIT RECK VCP TP53BP2

7.10e-07104614422ctd:D015127
DrugFluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A

TRIM25 NDUFAF5 SMC1A HMOX1 GRM8 ATM CAMSAP1 KIT DNMT3A

3.98e-0619314494129_DN
DrugDiethylstilbestrol

EPHX1 ATP6V1B2 TNC PSMC5 IDE HMOX1 ATG2A PAPSS2 ATP10D ARG2 PTPRC NALCN FZD5 SCARB2 CAMTA1 RPA3 KIT RASAL1 CDH16 VCP TP53BP2 DNMT3A DNMT3B

7.59e-06130514423ctd:D004054
Drugmalonate

HMOX1 GRM4 GRM8 KCNH6 PTPRD KCNH1 AASS ACSF3 PC

7.60e-062091449CID000000867
Drugalpha-AASA

AASDH IDE ARG2 PIK3C2A AASS

9.41e-06451445CID000000207
DiseaseOsteosarcoma

RFC1 GRM4 MST1R KCNH1 ZW10

3.14e-06471425C0029463
DiseaseNeurodevelopmental Disorders

DOCK8 SMC1A PTK7 DHX30 KCNH1 WDFY3

6.04e-06931426C1535926
Diseasesusceptibility to rheumatic fever measurement

MSH3 RYR3 SLIT2 PTPRD

9.62e-06281424EFO_0008416
DiseaseMastocytosis, Systemic

HMOX1 KIT

2.30e-0521422C0221013
DiseaseIndolent Systemic Mastocytosis

HMOX1 KIT

2.30e-0521422C0272203
DiseaseAggressive Systemic Mastocytosis

HMOX1 KIT

2.30e-0521422C1112486
Diseaseinclusion body myopathy with Paget disease of bone and frontotemporal dementia (implicated_via_orthology)

PSMC5 VCP

2.30e-0521422DOID:0050881 (implicated_via_orthology)
Diseaseendometriosis of uterus (is_marker_for)

DNMT3A DNMT3B

6.88e-0531422DOID:288 (is_marker_for)
DiseaseZimmerman Laband syndrome

ATP6V1B2 KCNH1

6.88e-0531422C0796013
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

EPHX1 MSH3 ATM

9.99e-05191423C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

EPHX1 MSH3 ATM

9.99e-05191423C2936783
Diseaseisobutyrylglycine measurement

GLB1L3 CPS1

1.37e-0441422EFO_0800029
Diseasecongenital heart disease (biomarker_via_orthology)

DNMT3A DNMT3B

1.37e-0441422DOID:1682 (biomarker_via_orthology)
DiseaseImmunologic Deficiency Syndromes

EPG5 ATM DNMT3B

1.80e-04231423C0021051
Diseaseaspartate measurement

CPS1 NDST3 ENPEP

2.05e-04241423EFO_0010462
Diseaseileus (biomarker_via_orthology)

HMOX1 KIT

2.28e-0451422DOID:8440 (biomarker_via_orthology)
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

EPHX1 MSH3 ATM

2.62e-04261423C0009405
DiseaseHereditary non-polyposis colorectal cancer syndrome

EPHX1 MSH3 ATM

2.93e-04271423C1112155
DiseaseIntellectual Disability

DOCK8 FARSB GTF3C3 NFIA AASS SNX27 VPS53 DNMT3A CNDP1

3.28e-044471429C3714756
DiseaseHereditary Nonpolyposis Colorectal Cancer

EPHX1 MSH3 ATM

3.64e-04291423C1333990
DiseaseLiver Cirrhosis, Experimental

AADAC ERAP1 MAP3K8 HMOX1 CPS1 ATP10D PTPRC PTPRD PC ENPEP RECK CNDP1

3.79e-0477414212C0023893
Diseaseendoplasmic reticulum aminopeptidase 1 measurement

ERAP1 ERAP2

4.75e-0471422EFO_0008119
DiseaseColorectal Carcinoma

VPS18 PSMC5 LGR5 MFN1 NDST3 POSTN PPP2R1B PTPRD CAMSAP2 SORL1 PDZRN4

6.10e-0470214211C0009402
Diseasepulmonary hypertension (biomarker_via_orthology)

TNC HMOX1 MFN1 RYR3

6.12e-04801424DOID:6432 (biomarker_via_orthology)
Diseasesevere pre-eclampsia (is_marker_for)

ERAP1 ERAP2

6.32e-0481422DOID:13129 (is_marker_for)
DiseaseHereditary Motor and Sensory Neuropathy Type I

MORC2 FIG4

6.32e-0481422C0751036
DiseaseRoussy-Levy Syndrome (disorder)

MORC2 FIG4

6.32e-0481422C0205713
Diseasesporadic amyotrophic lateral sclerosis, survival time

IDE CAMTA1

6.32e-0481422EFO_0000714, EFO_0001357
DiseaseCharcot-Marie-Tooth Disease, Type Ib

MORC2 FIG4

6.32e-0481422C0270912
DiseaseCharcot-Marie-Tooth Disease, Type Ia (disorder)

MORC2 FIG4

6.32e-0481422C0270911
Diseasecreatine measurement

TNC CPS1 ENPEP

6.93e-04361423EFO_0010472
DiseaseMalignant neoplasm of breast

ABHD12B HMOX1 EPG5 PTPRC PTPRD KCNH1 ATM HERC2 KIT ENPEP TP53BP2 DNMT3A SORL1 DNMT3B

7.01e-04107414214C0006142
Diseaseacute myeloid leukemia (is_implicated_in)

EPHX1 KIT DNMT3A DNMT3B

7.36e-04841424DOID:9119 (is_implicated_in)
DiseaseProstatic Neoplasms

EPHX1 MSH3 HMOX1 DHX30 ARG2 PTPRC USP7 ATM VCP DNMT3B

8.27e-0461614210C0033578
DiseaseMalignant neoplasm of prostate

EPHX1 MSH3 HMOX1 DHX30 ARG2 PTPRC USP7 ATM VCP DNMT3B

8.27e-0461614210C0376358
DiseaseColonic Neoplasms

RFC1 LGR5 MEP1A PARP4 RECK

8.64e-041521425C0009375
DiseaseNeoplasm Recurrence, Local

TLK1 KIT DNMT3A

8.78e-04391423C0027643
Diseaselung cancer (is_marker_for)

TNC DNMT3A DNMT3B

8.78e-04391423DOID:1324 (is_marker_for)
DiseaseLymphoma

EPHX1 DOCK8 ATM

9.46e-04401423C0024299
DiseasePeripheral T-Cell Lymphoma

ATM DNMT3A

1.01e-03101422C0079774
DiseaseMalignant tumor of colon

RFC1 LGR5 MEP1A PARP4 RECK

1.06e-031591425C0007102
DiseaseAdenocarcinoma of large intestine

PTK7 NRK ATM KIT

1.21e-03961424C1319315
DiseaseBreast Carcinoma

HMOX1 PTPRD KCNH1 ATM HERC2 KIT TP53BP2 DNMT3A DNMT3B

1.22e-035381429C0678222
Diseasepulmonary emphysema (is_implicated_in)

EPHX1 HMOX1

1.23e-03111422DOID:9675 (is_implicated_in)
DiseaseAcute Promyelocytic Leukemia

SMC1A KIT DNMT3A

1.42e-03461423C0023487
DiseaseAlzheimer's Disease

IDE HMOX1 UNC5C SORL1

1.46e-031011424C0002395
DiseaseCentriacinar Emphysema

EPHX1 HMOX1

1.47e-03121422C0221227
DiseasePanacinar Emphysema

EPHX1 HMOX1

1.47e-03121422C0264393
Diseaseprostatitis (biomarker_via_orthology)

DNMT3A DNMT3B

1.47e-03121422DOID:14654 (biomarker_via_orthology)
DiseaseFocal Emphysema

EPHX1 HMOX1

1.47e-03121422C2350878
DiseaseCharcot-Marie-Tooth Disease

MORC2 FIG4

1.47e-03121422C0007959
Diseasefrontal fibrosing alopecia

ERAP1 GRM8 ERAP2

1.61e-03481423EFO_0009855
Diseaseautoimmune thrombocytopenic purpura (is_marker_for)

DNMT3A DNMT3B

1.73e-03131422DOID:8924 (is_marker_for)
DiseaseHereditary Motor and Sensory-Neuropathy Type II

MORC2 FIG4

1.73e-03131422C0270914
DiseaseNeoplasm of lung

MAP3K8 PPP2R1B

2.01e-03141422cv:C0024121
DiseaseLung cancer

MAP3K8 PPP2R1B

2.01e-03141422cv:C0242379
DiseaseLUNG CANCER

MAP3K8 PPP2R1B

2.01e-03141422211980
Diseaseserum metabolite measurement

ERAP1 CPS1 PAPSS2 ATP10D AGXT2 SLIT2 PARP4 TLK1 NFIA ERAP2 ENPEP PDZRN4

2.10e-0394514212EFO_0005653
Diseasemonoclonal gammopathy

TNC CPS1 PTPRD

2.14e-03531423EFO_0000203
DiseaseSmall cell carcinoma of lung

GRM8 SLIT2 KIT

2.26e-03541423C0149925
Diseaseglycerate measurement

RYR3 HMCN1

2.32e-03151422EFO_0021029
Diseasephenylalanine measurement

VPS18 WASHC4 CPS1

2.38e-03551423EFO_0005001
Diseaseproliferative diabetic retinopathy (is_marker_for)

MAP3K8 SLIT2

2.64e-03161422DOID:13207 (is_marker_for)
Diseaseidiopathic scoliosis (implicated_via_orthology)

DNAH10 PTK7

2.64e-03161422DOID:0060250 (implicated_via_orthology)
DiseasePre-Eclampsia

EPHX1 HMOX1

2.64e-03161422C0032914
DiseasePulmonary Emphysema

EPHX1 HMOX1

2.98e-03171422C0034067
DiseaseAmyotrophic lateral sclerosis

FIG4 VCP

2.98e-03171422cv:C0002736
DiseaseAntibody Deficiency Syndrome

EPG5 DNMT3B

2.98e-03171422C0003257
Diseasenon-Hodgkin lymphoma (is_implicated_in)

EPHX1 MALT1

2.98e-03171422DOID:0060060 (is_implicated_in)
DiseaseAcute myeloid leukemia

KIT DNMT3A

2.98e-03171422cv:C0023467
DiseaseLEUKEMIA, ACUTE MYELOID

KIT DNMT3A

2.98e-03171422601626
DiseaseDrug-Induced Liver Disease

EPHX1 HMOX1 CPS1 MST1R AASS PC SORL1

3.51e-034041427C0860207
DiseaseDrug-Induced Acute Liver Injury

EPHX1 HMOX1 CPS1 MST1R AASS PC SORL1

3.51e-034041427C3658290
DiseaseHepatitis, Toxic

EPHX1 HMOX1 CPS1 MST1R AASS PC SORL1

3.51e-034041427C0019193
DiseaseChemically-Induced Liver Toxicity

EPHX1 HMOX1 CPS1 MST1R AASS PC SORL1

3.51e-034041427C4279912
DiseaseChemical and Drug Induced Liver Injury

EPHX1 HMOX1 CPS1 MST1R AASS PC SORL1

3.51e-034041427C4277682
DiseaseHepatitis, Drug-Induced

EPHX1 HMOX1 CPS1 MST1R AASS PC SORL1

3.51e-034041427C1262760
DiseaseMammary Carcinoma, Human

HMOX1 PTPRD KCNH1 ATM KIT TP53BP2 DNMT3A DNMT3B

4.01e-035251428C4704874
DiseaseMammary Neoplasms, Human

HMOX1 PTPRD KCNH1 ATM KIT TP53BP2 DNMT3A DNMT3B

4.01e-035251428C1257931
DiseaseMammary Neoplasms

HMOX1 PTPRD KCNH1 ATM KIT TP53BP2 DNMT3A DNMT3B

4.10e-035271428C1458155
Diseaseserum homoarginine measurement

CPS1 AGXT2

4.13e-03201422EFO_0005421
Diseasecitrulline measurement

CPS1 PTPRE

4.13e-03201422EFO_0009777
Diseasegestational age

SLIT2 SLMAP VWA3B CAMTA1

4.52e-031381424EFO_0005112
DiseaseLung Injury

TNC HMOX1

4.55e-03211422C0273115
DiseaseChronic Lung Injury

TNC HMOX1

4.55e-03211422C2350344
DiseaseOvarian Failure, Premature

MCM8 STAG3

4.55e-03211422C0085215

Protein segments in the cluster

PeptideGeneStartEntry
YTLHKILPNKVDPLV

PSMC5

121

P62195
AIRPLIPLKHQVEYD

USH1C

61

Q9Y6N9
HTPVALEAYFVPLVK

PPP2R1B

131

P30154
PVVTAYFQKPLLLHQ

AGXT2

76

Q9BYV1
TVVHVLDKILPLFYP

EPG5

1056

Q9HCE0
NPDIVLVHYLNVPAI

CAMTA1

171

Q9Y6Y1
VDPPEHFILKNYDIQ

ARG2

201

P78540
FPVKIEIPLFHVLNA

ANKRD13D

406

Q6ZTN6
PVIRHLFAPLKEYFA

DNMT3A

896

Q9Y6K1
VPVIRHLFAPLKDYF

DNMT3B

836

Q9UBC3
RLAPKYHFPIQFEDV

AADAC

146

P22760
KVYIILFHPEQNVPK

GRM4

841

Q14833
KQDLVISLLPYVLHP

AASS

546

Q9UDR5
LKIPHTVNFYLRVEP

ABHD12B

91

Q7Z5M8
VAVPLYRKHPAAQLE

ACSF3

121

Q4G176
LQKYLPSHAVPDELV

AASDH

501

Q4L235
INVLIKDLFHIPPSY

API5

421

Q9BZZ5
VEPDYRLFVVHLLPK

CEP72

116

Q9P209
PEPILRKIETFLNHY

DHX30

351

Q7L2E3
VDQYEQEHIKPPVIK

CAMSAP1

66

Q5T5Y3
LKLHQIEYVVFGEIP

CFAP44

1621

Q96MT7
YLHVEPEKEVVSLVP

TP53BP2

791

Q13625
ILPSVHIFLPSKEVY

ATG2A

816

Q2TAZ0
RIVVPHIQPFKDEYE

ATP10D

51

Q9P241
TLPPVQLAHKYFELF

NDST3

551

O95803
PAIRYHPQETLKEFV

NFIA

386

Q12857
PYLHEVLKPVISRVF

RASAL1

361

O95294
LPDQEKAVSEHIPYL

PDZRN4

816

Q6ZMN7
KAFAHLQVPERVVPY

HSPG2

3651

P98160
SEIVILIIPVDHYPK

RECK

881

O95980
LIIPVDHYPKALQIE

RECK

886

O95980
LKEVQPLHVVCPEQY

INTS9

461

Q9NV88
PIRKEVIHLEPYIAL

P4HA3

336

Q7Z4N8
IPQFKPEIQVYENIH

LY6G6F

271

Q5SQ64
FHPNPDVLKIYKSEL

MFN1

431

Q8IWA4
VHIFLANLYVLVPPV

OR52D1

276

Q9H346
PELLSPVEHYLKILN

MSH3

676

P20585
LITPQVAKLEHAYKP

PATL1

461

Q86TB9
VPYTIIKDIHELFVP

PAPSS2

216

O95340
KYFPIPVEHLEEEIR

PTPRE

111

P23469
APIHKLEEALYEYQP

MNAT1

236

P51948
ETIDPIPHQLLRKYI

MCM8

656

Q9UJA3
HPEIISYLEKVIPLI

LETMD1

191

Q6P1Q0
VDLIVEYEAFPKPEH

KIT

331

P10721
HPKLKAPLVDVYELT

MALT1

356

Q9UDY8
FVIQVLDKYNPPDHF

HERC2

4741

O95714
AVEKYFDHLIPRVIP

GLB1L3

196

Q8NCI6
HKAYVKTPEQPQIVL

KIAA2026

1536

Q5HYC2
ADVLPEYKLQAPRIH

KCNH6

231

Q9H252
YEDFIVKPPVRKLVH

DYNC1LI2

336

O43237
RVFHYENLKPVVEPN

FSIP2

3301

Q5CZC0
YIIHKQAPPLEDIAD

MAP3K8

341

P41279
KIRLPEYVIPVHYDL

ERAP1

51

Q9NZ08
NIIPVLEDARHPLKY

FBLL1

221

A6NHQ2
EKEFHVLPYRVFVPL

ODR4

336

Q5SWX8
TPVDLNKHLYQIEKP

PIK3C2A

526

O00443
EYRLVPKVYFPEQIH

NCEH1

146

Q6PIU2
PKVYFPEQIHDVVRA

NCEH1

151

Q6PIU2
IKAYSPELIVHPVLD

NAXD

116

Q8IW45
ILAEVKHSFYPIPEQ

KCNH1

906

O95259
VILALVLPFHPYVEN

METTL9

236

Q9H1A3
KFERPQYAEILLAHP

MORF4L2

201

Q15014
FVNPVHYDLHVKPLL

ENPEP

96

Q07075
VATEPVLHKPVYLFL

OR52P1

51

Q8NH57
VKDVFLVPLAYFLHP

NUDT7

141

P0C024
EIPHLPQDFEVAKYN

PARP4

141

Q9UKK3
PKVYIIIFHPEQNVQ

GRM8

836

O00222
VQYAIPSKQPEFHIE

IQCF3

136

P0C7M6
IKHYEVKVYIPPIIN

HMCN1

2656

Q96RW7
ISPHLKEYVIAVDKP

HMCN1

4081

Q96RW7
VPYLVLEPTHNKQDF

MORC2

416

Q9Y6X9
LHLPDIKFFPNVYAL

THAP12

666

O43422
FVPILKESHPLYNKV

FZD5

196

Q13467
YITIKLLDPFPDHVV

ATM

1556

Q13315
LDHPIIPADYVAIKA

CPS1

1296

P31327
EFYKIIPLLTDPKNH

EPHX1

156

P07099
HKEILEFPTREVYVP

DOCK8

541

Q8NF50
KHLPLPYDEVICAVN

FIG4

641

Q92562
LDIPKVQHVIHYQVP

DDX24

651

Q9GZR7
LLNIPINDIIHPKYF

DNAJB13

256

P59910
SYPAHEQIALLVPEK

ERAP2

141

Q6P179
PVYFPEELHRKAALE

HMOX1

76

P09601
LRFIIQSEKPPHYLE

IDE

846

P14735
KVVETLPHFISPYLE

HEATR1

1766

Q9H583
VTKVFHVDYEPPNIV

DZANK1

96

Q9NVP4
KLVPEYIHAPERKFI

DNAH10

2411

Q8IVF4
QIPPIHEQFAILEKY

DNAH2

1091

Q9P225
QYDQEHIKPPVVNLL

CAMSAP2

61

Q08AD1
LEPIHLAENLKVLYP

CDH16

241

O75309
PYPEVDHFVLSLVNK

PRIMPOL

376

Q96LW4
NPLLYILFNPHFKED

LGR5

816

O75473
VELKPYIAAHFDVLP

PTPRD

1186

P23468
RVHILPPQTKYFEIN

CFAP221

91

Q4G0U5
HSIQAEVQIEPLKPY

NRK

761

Q7Z2Y5
VIQKKVLYPASEPLH

RTKN2

481

Q8IZC4
PLVILDHVKFPRYAE

ATP6V1B2

56

P21281
ILDNLPHPYAIAVFK

SORL1

956

Q92673
VYHALNPKLTVIVPD

TMEM248

246

Q9NWD8
VIPFIHLPEIVNLYN

SLC16A14

331

Q7RTX9
APLFVQENYIHVKPV

RFC1

881

P35251
EQNIPVSKIITHPEY

OVCH1

116

Q7RTY7
VFKERIGYPHLQEVL

NBEAL2

401

Q6ZNJ1
FAHIAAVPIKYLPEE

MEP1A

16

Q16819
AVPIKYLPEENVHDA

MEP1A

21

Q16819
FHPLITKDEVLYVFP

SCARB2

256

Q14108
HFLPNPYFRNEVLVK

NAP1L3

361

Q99457
LAEEVFQHIPYIKEP

IARS2

841

Q9NSE4
IIDEQPLIFKNDPYH

LIMS1

141

P48059
LEQIHYILKPDGVFI

NDUFAF5

171

Q5TEU4
EAVKIIHDFPQFYPL

RPA3

101

P35244
LHIIENKPLYPVIYD

FARSB

211

Q9NSD9
IHYYQKALELPPLVV

GTF3C3

831

Q9Y5Q9
ELPLDYHQYVVPKIQ

CCDC15

691

Q0P6D6
YVVQEVLSIKHLPPQ

NCAPD2

26

Q15021
PPALLEKVFQYIDLH

CNDP1

31

Q96KN2
IPPDIAKLHNLVYLD

CNOT6L

71

Q96LI5
LPAPENIHNIVKTFY

PIGA

371

P37287
PFLDAQYQKVPVLFH

RNF213

2041

Q63HN8
IEEKDVVYKHFPIPL

RNF213

3151

Q63HN8
VVYKHFPIPLINRLE

RNF213

3156

Q63HN8
FPIPLINRLEKHYLD

RNF213

3161

Q63HN8
ALRYLNEIKPPIIHY

TLK1

571

Q9UKI8
VYPPKNVADLKLHVT

WDFY3

821

Q8IZQ1
EVPHQVILPALTLVY

STAG3

736

Q9UJ98
KRELQELVQYPVEHP

VCP

486

P55072
ELVQYPVEHPDKFLK

VCP

491

P55072
LLFKLHIPPAYTEVK

TBC1D8B

901

Q0IIM8
TEKQPDPLHQIILYF

RYR3

3546

Q15413
PFQERHVYLDEPIKI

SLMAP

16

Q14BN4
PVYIPEVELNHKLIK

TRIM25

321

Q14258
DPQLFYKFSPILIRH

VPS18

591

Q9P253
LIQEPKVHEPVRIAY

SUGP2

971

Q8IX01
QPVVFNHVYNIKLPV

TNC

46

P24821
PEKIHNKLEFPQVLY

USP25

386

Q9UHP3
AKLVIDVIRYEPPHI

SMC1A

591

Q14683
QAVPISVPRYKHVEQ

SNX27

161

Q96L92
KIPEHIPQYTAELRL

SLIT2

526

O94813
TLKKYFIPVIEIVPH

USP9Y

271

O00507
PHEPLVVFVDNYIKL

VPS53

746

Q5VIR6
ENLPPHIIRLVYKEV

UBE2S

6

Q16763
PLFKPELIYQLDHRQ

ZNF543

51

Q08ER8
KNIHLRNFYIIVPPL

WASHC4

1006

Q2M389
FYVPAIVIALPNKHV

VWA3B

1111

Q502W6
IHVVDKLLYPADTPV

POSTN

621

Q15063
TALHLKDYEDIIPPV

WDR35

1051

Q9P2L0
NVIPYDYNRVPLKHE

PTPRC

976

P08575
NIKHTEAPLYVVDKP

PTK7

671

Q13308
DPKDPANYILHAVLV

USP7

441

Q93009
LPHFLIEPEEAYIVK

UNC5C

61

O95185
APVQAYLHIPDIIKV

PC

91

P11498
VPLKPEEHAIKFEYI

MST1R

871

Q04912
LVKYEHKLTLPEPQQ

TEX46

41

H3BTG2
DVVPTYHKENLQKLP

ZW10

521

O43264
VIQNVIDHVPKPHYL

AK7

261

Q96M32
LRENHPYFDKPLFIV

NALCN

826

Q8IZF0