Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	BACE1 ERVK-9 ERVK-10 ERVK-19 ERVK-24 ERVK-8	1.33e-06	37	192	6	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	BACE1 ERVK-9 ERVK-10 ERVK-19 ERVK-24 ERVK-8	1.56e-06	38	192	6	GO:0070001
GeneOntologyMolecularFunction	transforming growth factor beta receptor activity, type I	ACVR1 BMPR1A BMPR1B	8.63e-06	5	192	3	GO:0005025
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	SLK ERN1 PBK ERVK-10 ACVR1 PFKFB4 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 REV1 MAP3K8 POLR2B POLR2G MAP3K14 OAS2 PDPK2P CSNK1G2 N4BP2 ERVK-8 PRKCZ MUSK	1.22e-05	938	192	24	GO:0016772
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 PDPK2P CSNK1G2 PRKCZ	2.86e-05	446	192	15	GO:0004674
GeneOntologyMolecularFunction	BMP receptor activity	ACVR1 BMPR1A BMPR1B	4.73e-05	8	192	3	GO:0098821
GeneOntologyMolecularFunction	methionine adenosyltransferase activity	MAT1A MAT2A	9.20e-05	2	192	2	GO:0004478
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	SLK ERN1 PBK ACVR1 PFKFB4 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 PDPK2P CSNK1G2 N4BP2 PRKCZ MUSK	1.76e-04	709	192	18	GO:0016773
GeneOntologyMolecularFunction	transforming growth factor beta receptor activity	ACVR1 BMPR1A BMPR1B	2.33e-04	13	192	3	GO:0005024
GeneOntologyMolecularFunction	protein kinase activity	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 PDPK2P CSNK1G2 PRKCZ MUSK	2.35e-04	600	192	16	GO:0004672
GeneOntologyMolecularFunction	endonuclease activity	ERCC4 ERN1 MRPL44 ERVK-10 XRCC4 N4BP2 ERVK-8	3.50e-04	136	192	7	GO:0004519
GeneOntologyMolecularFunction	kinase activity	SLK ERN1 PBK ACVR1 PFKFB4 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 PDPK2P CSNK1G2 N4BP2 PRKCZ MUSK	4.31e-04	764	192	18	GO:0016301
GeneOntologyMolecularFunction	3' overhang single-stranded DNA endodeoxyribonuclease activity	ERCC4 XRCC4	5.45e-04	4	192	2	GO:1990599
GeneOntologyMolecularFunction	hyaluronan synthase activity	HAS1 HAS2	5.45e-04	4	192	2	GO:0050501
GeneOntologyMolecularFunction	protein serine kinase activity	SLK ERN1 PBK RPS6KC1 STK32A CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ	8.08e-04	363	192	11	GO:0106310
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	ACVR1 BMPR1A BMPR1B	8.84e-04	20	192	3	GO:0004675
GeneOntologyMolecularFunction	endopeptidase activity	BACE1 ERVK-9 ERVK-10 BMP1 MALT1 ERVK-19 ERVK-24 NRDC ADAM30 CFI ERVK-8 CORIN	9.66e-04	430	192	12	GO:0004175
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5B KDM5A	1.35e-03	6	192	2	GO:0034647
Domain	Ser/Thr_kinase_AS	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ	1.19e-05	357	183	14	IPR008271
Domain	S_TKc	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ	1.27e-05	359	183	14	SM00220
Domain	PROTEIN_KINASE_ST	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ	1.39e-05	362	183	14	PS00108
Domain	Pkinase	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ	2.45e-05	381	183	14	PF00069
Domain	GS_dom	ACVR1 BMPR1A BMPR1B	3.15e-05	7	183	3	IPR003605
Domain	GS	ACVR1 BMPR1A BMPR1B	3.15e-05	7	183	3	PS51256
Domain	TGF_beta_GS	ACVR1 BMPR1A BMPR1B	3.15e-05	7	183	3	PF08515
Domain	GS	ACVR1 BMPR1A BMPR1B	3.15e-05	7	183	3	SM00467
Domain	PROTEIN_KINASE_ATP	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ MUSK	4.85e-05	459	183	15	PS00107
Domain	S-AdoMet_synt_N	MAT1A MAT2A	9.55e-05	2	183	2	PF00438
Domain	S-AdoMet_synthetase	MAT1A MAT2A	9.55e-05	2	183	2	IPR002133
Domain	NECAP_PHear	NECAP1 NECAP2	9.55e-05	2	183	2	IPR012466
Domain	S-AdoMet_synt_M	MAT1A MAT2A	9.55e-05	2	183	2	PF02772
Domain	S-AdoMet_synt_C	MAT1A MAT2A	9.55e-05	2	183	2	PF02773
Domain	ADOMET_SYNTHASE_CS	MAT1A MAT2A	9.55e-05	2	183	2	IPR022631
Domain	S-AdoMet_synt_C	MAT1A MAT2A	9.55e-05	2	183	2	IPR022630
Domain	S-AdoMet_synthetase_sfam	MAT1A MAT2A	9.55e-05	2	183	2	IPR022636
Domain	S-AdoMet_synt_central	MAT1A MAT2A	9.55e-05	2	183	2	IPR022629
Domain	S-AdoMet_synt_N	MAT1A MAT2A	9.55e-05	2	183	2	IPR022628
Domain	DUF1681	NECAP1 NECAP2	9.55e-05	2	183	2	PF07933
Domain	ADOMET_SYNTHASE_1	MAT1A MAT2A	9.55e-05	2	183	2	PS00376
Domain	ADOMET_SYNTHASE_2	MAT1A MAT2A	9.55e-05	2	183	2	PS00377
Domain	Prot_kinase_dom	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ MUSK	9.85e-05	489	183	15	IPR000719
Domain	JmjN	KDM5B KDM5A KDM4A	1.06e-04	10	183	3	SM00545
Domain	JmjN	KDM5B KDM5A KDM4A	1.06e-04	10	183	3	PF02375
Domain	Activin_recp	ACVR1 BMPR1A BMPR1B	1.06e-04	10	183	3	PF01064
Domain	Activin_recp	ACVR1 BMPR1A BMPR1B	1.06e-04	10	183	3	IPR000472
Domain	JMJN	KDM5B KDM5A KDM4A	1.06e-04	10	183	3	PS51183
Domain	JmjN	KDM5B KDM5A KDM4A	1.06e-04	10	183	3	IPR003349
Domain	PROTEIN_KINASE_DOM	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ MUSK	1.08e-04	493	183	15	PS50011
Domain	TGFB_receptor	ACVR1 BMPR1A BMPR1B	1.91e-04	12	183	3	IPR000333
Domain	CK1gamma_C	CSNK1G1 CSNK1G2	2.85e-04	3	183	2	PF12605
Domain	HAS/NodC	HAS1 HAS2	2.85e-04	3	183	2	IPR026107
Domain	Casein_kinase-1_gamma_C	CSNK1G1 CSNK1G2	2.85e-04	3	183	2	IPR022247
Domain	Kinase-like_dom	SLK ERN1 PBK ACVR1 RPS6KC1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K8 MAP3K14 CSNK1G2 PRKCZ MUSK	3.00e-04	542	183	15	IPR011009
Domain	Lys_sp_deMease-like_dom	KDM5B KDM5A	5.66e-04	4	183	2	IPR013637
Domain	PLU-1	KDM5B KDM5A	5.66e-04	4	183	2	PF08429
Domain	zf-C5HC2	KDM5B KDM5A	9.36e-04	5	183	2	PF02928
Domain	Znf_C5HC2	KDM5B KDM5A	9.36e-04	5	183	2	IPR004198
Domain	Protein_kinase_ATP_BS	SLK ACVR1 STK32A BMPR1A BMPR1B CSNK1G1 MAP4K4 MAP3K14 CSNK1G2 PRKCZ MUSK	1.32e-03	379	183	11	IPR017441
Domain	UmuC	ESCO1 REV1	1.40e-03	6	183	2	IPR001126
Pubmed	The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development.	ACVR1 BMPR1A BMPR1B	1.68e-07	3	193	3	25413979
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	ERN1 MAT2A ACVR1 BMPR1A DIAPH2 MAP4K4 ANKRD52 TCTN1 FBXO34 REV1 VEZT CSNK1G2 TTI1 KDM4A ACCSL	3.69e-07	536	193	15	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	ERN1 MAT2A ACVR1 BMPR1A DIAPH2 MAP4K4 ANKRD52 TCTN1 FBXO34 REV1 VEZT CSNK1G2 TTI1 KDM4A ACCSL	3.87e-07	538	193	15	10512203
Pubmed	Common genetic variants of the BMP4, BMPR1A, BMPR1B, and ACVR1 genes, left ventricular mass, and other parameters of the heart in newborns.	ACVR1 BMPR1A BMPR1B	6.70e-07	4	193	3	22971142
Pubmed	Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteins.	ACVR1 BMPR1A BMPR1B	6.70e-07	4	193	3	8605036
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-10 ERVK-19 ERVK-5	6.70e-07	4	193	3	7983737
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ERCC4 SETX RPS6KC1 PHC3 BMPR1A VPS33B BAIAP3 NRDC POLR2B COPG2 BTLA GPR183 PRAMEF17 CUBN NPHP3 PPP3CB UNC5C HMGXB3 PRKCZ ACCSL TNS1	7.58e-07	1084	193	21	11544199
Pubmed	Role of BMP Signaling for the Formation of Auditory Brainstem Nuclei and Large Auditory Relay Synapses.	ACVR1 BMPR1A BMPR1B	1.67e-06	5	193	3	30548566
Pubmed	Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.	ACVR1 BMPR1A BMPR1B	1.67e-06	5	193	3	27048979
Pubmed	eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling.	NOS3 NOTCH1 DLL4 HAS2	2.65e-06	18	193	4	38111957
Pubmed	Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.	ACVR1 BMPR1A BMPR1B	3.32e-06	6	193	3	8006002
Pubmed	NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.	MAP4K4 MAP3K8 MAP3K14	3.32e-06	6	193	3	18439422
Pubmed	BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse.	ACVR1 BMPR1A BMPR1B	3.32e-06	6	193	3	25641697
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ACLY MRPL44 PBK NDUFA10 VPS33B HSP90AB1 IRS4 IPO7 NRDC COPB1 POLR2B COPG2 PPP1R10 WDR6	3.39e-06	560	193	14	35241646
Pubmed	SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.	ACVR1 BMPR1A BMPR1B	5.79e-06	7	193	3	12065756
Pubmed	Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.	ACVR1 BMPR1A BMPR1B	5.79e-06	7	193	3	18070108
Pubmed	Differential expression of BMP receptors in early mouse development.	ACVR1 BMPR1A BMPR1B	5.79e-06	7	193	3	9303341
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	SIX4 CEMIP2 VPS33B MTUS1 ANKRD52 NOTCH1 HSP90AB1 IRS4 IPO7 VEZT POLR2B POLR2G COPG2 PPP1R10 PPP3CB SLC12A4 TTI1 TNS1 FTSJ3	6.87e-06	1049	193	19	27880917
Pubmed	Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.	BMPR1A BMPR1B NOTCH1 DLL4	7.49e-06	23	193	4	14701881
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	SPTA1 ADGRV1 FCGBP MXRA5 XPNPEP2 PPP1R10	7.67e-06	84	193	6	15203218
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	MAT1A MAT2A NOS3 CUBN ATIC	7.81e-06	49	193	5	19161160
Pubmed	Loss of Gata5 in mice leads to bicuspid aortic valve.	NOS3 NOTCH1 DLL4 HAS2	8.95e-06	24	193	4	21633169
Pubmed	DRAGON, a bone morphogenetic protein co-receptor.	ACVR1 BMPR1A BMPR1B	9.23e-06	8	193	3	15671031
Pubmed	Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5.	ACVR1 BMPR1A BMPR1B	9.23e-06	8	193	3	8702914
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ACLY MAT1A MAT2A NSUN2 HSP90AB1 IRS4 IPO7 COPB1 POLR2B COPG2 ATIC ZNF682	9.30e-06	451	193	12	36168627
Pubmed	BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.	ACVR1 BMPR1A BMPR1B	1.38e-05	9	193	3	28641928
Pubmed	Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads.	ACVR1 BMPR1A BMPR1B	1.38e-05	9	193	3	12857866
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-9 ERVK-10 ERVK-19 ERVK-24 ERVK-8 ERVK-5	1.47e-05	94	193	6	21542922
Pubmed	Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.	ACVR1 BMPR1A BMPR1B	1.96e-05	10	193	3	15611116
Pubmed	RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.	ACVR1 BMPR1A BMPR1B	1.96e-05	10	193	3	15239668
Pubmed	BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.	ACVR1 BMPR1A BMPR1B	1.96e-05	10	193	3	18436533
Pubmed	Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).	ACVR1 BMPR1A BMPR1B	1.96e-05	10	193	3	11266516
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	CLUAP1 SETX ADGRV1 MAP4K4 KDM4A OGA	2.34e-05	102	193	6	9734811
Pubmed	BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo.	ACVR1 BMPR1A BMPR1B	2.69e-05	11	193	3	15289457
Pubmed	Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.	ACVR1 BMPR1A BMPR1B	2.69e-05	11	193	3	7791754
Pubmed	BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo.	ACVR1 BMPR1A BMPR1B	2.69e-05	11	193	3	20406889
Pubmed	Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.	ACVR1 BMPR1A BMPR1B	2.69e-05	11	193	3	19758997
Pubmed	Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.	BMPR1A IPO7 COPB1	2.69e-05	11	193	3	35842443
Pubmed	Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.	ERN1 CORIN	3.06e-05	2	193	2	25516437
Pubmed	A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer.	NOTCH1 DLL4	3.06e-05	2	193	2	11739188
Pubmed	Coding sequence of a hyaluronan synthase homologue expressed during expansion of the mouse cumulus-oocyte complex.	HAS1 HAS2	3.06e-05	2	193	2	9016821
Pubmed	NOTCH1 and DLL4 are involved in the human tuberculosis progression and immune response activation.	NOTCH1 DLL4	3.06e-05	2	193	2	32801053
Pubmed	Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.	NOS3 NOTCH1	3.06e-05	2	193	2	23583836
Pubmed	Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity.	IRS4 WDR6	3.06e-05	2	193	2	17720279
Pubmed	Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.	HAS1 HAS2	3.06e-05	2	193	2	22785117
Pubmed	Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-->q24 byin situ hybridization and radiation hybrid map ping.	BMPR1A BMPR1B	3.06e-05	2	193	2	9730621
Pubmed	Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme.	NOTCH1 DLL4	3.06e-05	2	193	2	23787764
Pubmed	Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues.	BMPR1A BMPR1B	3.06e-05	2	193	2	10850425
Pubmed	Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus.	NOTCH1 DLL4	3.06e-05	2	193	2	21598246
Pubmed	A novel IgA/Delta-like 4/Notch axis induces immunosuppressive activity in human dendritic cells.	NOTCH1 DLL4	3.06e-05	2	193	2	27117596
Pubmed	Differential molecular regulation of processing and membrane expression of Type-I BMP receptors: implications for signaling.	BMPR1A BMPR1B	3.06e-05	2	193	2	28357470
Pubmed	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	MAT1A MAT2A	3.06e-05	2	193	2	22318685
Pubmed	Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2).	BMPR1A BMPR1B	3.06e-05	2	193	2	15322331
Pubmed	Bone morphogenetic protein signaling through ACVR1 and BMPR1A negatively regulates bone mass along with alterations in bone composition.	ACVR1 BMPR1A	3.06e-05	2	193	2	29175363
Pubmed	Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells.	HAS1 HAS2	3.06e-05	2	193	2	33803805
Pubmed	A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.	MAT1A MAT2A	3.06e-05	2	193	2	29749642
Pubmed	Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth.	HAS1 HAS2	3.06e-05	2	193	2	22529214
Pubmed	[Influence of Delta-like ligand 4/Notch signal transduction pathway upon the biological behavior of human umbilical vein endothelial cells].	NOTCH1 DLL4	3.06e-05	2	193	2	20193271
Pubmed	Chemotactic Cues for NOTCH1-Dependent Leukemia.	CCR9 NOTCH1	3.06e-05	2	193	2	29666622
Pubmed	Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma.	HAS1 HAS2	3.06e-05	2	193	2	27184066
Pubmed	BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation.	BMPR1A BMPR1B	3.06e-05	2	193	2	32764110
Pubmed	[BMP7 signaling via BMPR1A, BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell].	BMPR1A BMPR1B	3.06e-05	2	193	2	20673479
Pubmed	Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.	HAS1 HAS2	3.06e-05	2	193	2	26521733
Pubmed	Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.	MAT1A MAT2A	3.06e-05	2	193	2	31234428
Pubmed	HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells.	ACVR1 BMPR1A	3.06e-05	2	193	2	26148958
Pubmed	Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.	MAT1A MAT2A	3.06e-05	2	193	2	29448301
Pubmed	KDM5 lysine demethylases are involved in maintenance of 3'UTR length.	KDM5B KDM5A	3.06e-05	2	193	2	28138513
Pubmed	eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia.	NOS3 XRCC4	3.06e-05	2	193	2	29050484
Pubmed	Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.	BMPR1A BMPR1B	3.06e-05	2	193	2	15102710
Pubmed	Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.	GRIA2 GRM3	3.06e-05	2	193	2	32581155
Pubmed	The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development.	NOTCH1 DLL4	3.06e-05	2	193	2	21700774
Pubmed	Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy.	NOTCH1 DLL4	3.06e-05	2	193	2	31676012
Pubmed	A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes.	NOS3 NOTCH1	3.06e-05	2	193	2	34504875
Pubmed	Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium.	BACE1 NOS3	3.06e-05	2	193	2	35673977
Pubmed	Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells.	MALT1 MAP3K14	3.06e-05	2	193	2	28448599
Pubmed	Dll4/Notch1 signalling pathway is required in collective invasion of salivary adenoid cystic carcinoma.	NOTCH1 DLL4	3.06e-05	2	193	2	33469672
Pubmed	KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.	KDM5B KDM5A	3.06e-05	2	193	2	30472020
Pubmed	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.	MAT1A MAT2A	3.06e-05	2	193	2	27076759
Pubmed	DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice.	NOTCH1 DLL4	3.06e-05	2	193	2	25355291
Pubmed	The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6.	ACVR1 BMPR1A	3.06e-05	2	193	2	24501215
Pubmed	New insights into the pathobiology of Down syndrome--hyaluronan synthase-2 overexpression is regulated by collagen VI α2 chain.	COL6A2 HAS2	3.06e-05	2	193	2	23452080
Pubmed	Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.	ACVR1 NOTCH1	3.06e-05	2	193	2	11290335
Pubmed	KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.	KDM5B KDM5A	3.06e-05	2	193	2	34184733
Pubmed	BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.	BMPR1A BMPR1B	3.06e-05	2	193	2	31769494
Pubmed	Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis.	KDM5B KDM5A	3.06e-05	2	193	2	36509829
Pubmed	Probing Notch1-Dll4 signaling in regulating osteogenic differentiation of human mesenchymal stem cells using single cell nanobiosensor.	NOTCH1 DLL4	3.06e-05	2	193	2	35725756
Pubmed	Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration.	NOTCH1 DLL4	3.06e-05	2	193	2	25766473
Pubmed	Downregulation of Notch signaling by gamma-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines.	BACE1 NOTCH1	3.06e-05	2	193	2	19057901
Pubmed	BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo.	ACVR1 BMPR1A	3.06e-05	2	193	2	15531373
Pubmed	Functional analysis of a novel, thyroglobulin-embedded microRNA gene deregulated in papillary thyroid carcinoma.	MAP4K4 TG	3.06e-05	2	193	2	28855631
Pubmed	BMPR1A-mediated BMP1 signalling is disrupted in the cadmium-induced omphalocele in the chick model.	BMP1 BMPR1A	3.06e-05	2	193	2	21258932
Pubmed	Proteomic analysis of bovine axonemes exposed to acute alcohol: role of endothelial nitric oxide synthase and heat shock protein 90 in cilia stimulation.	NOS3 HSP90AB1	3.06e-05	2	193	2	23078267
Pubmed	Expression levels of Notch1 and Delta-like 4 in peripheral lymphocytes and their relationship with T helper 17 (Th17) cells in renal transplant recipients.	NOTCH1 DLL4	3.06e-05	2	193	2	26070613
Pubmed	Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization.	HAS1 HAS2	3.06e-05	2	193	2	20823158
Pubmed	Dll4, a novel Notch ligand expressed in arterial endothelium.	NOTCH1 DLL4	3.06e-05	2	193	2	10837024
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KDM5B LONRF1 MAT2A NDUFA10 NSUN2 TRIM66 MAP4K4 HSP90AB1 COPB1 KDM5A WDR47 ARRB1 PPP3CB DNAJC14 TRIM9 PDE4DIP PPP1R16B KDM4A ATIC CADPS2	3.45e-05	1285	193	20	35914814
Pubmed	Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells.	ACVR1 BMPR1A BMPR1B	3.57e-05	12	193	3	15913604
Pubmed	Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.	ACVR1 BMPR1A BMPR1B	3.57e-05	12	193	3	25872870
Pubmed	RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits.	POLR2B POLR2G CTDP1	3.57e-05	12	193	3	15282305
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-9 ERVK-19 ERVK-8	3.57e-05	12	193	3	14557543
Interaction	AMHR2 interactions	BMPR1A BMPR1B HSP90AA4P HSP90AB1 HSP90AB3P SLC12A4 PRKCZ	8.36e-07	56	187	7	int:AMHR2
Interaction	STK35 interactions	BMPR1B HSP90AA4P HSP90AB1 HSP90AB3P WDR6	7.70e-06	30	187	5	int:STK35
GeneFamily	Type 1 receptor serine/threonine kinases	ACVR1 BMPR1A BMPR1B	8.84e-06	7	116	3	345
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5B KDM5A KDM4A	4.72e-04	24	116	3	485
GeneFamily	Glycosyltransferase family 2	HAS1 HAS2	6.02e-04	6	116	2	428
GeneFamily	Immunoglobulin like domain containing	HEPACAM MALT1 MXRA5 BTLA CCDC141 MUSK	1.54e-03	193	116	6	594
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	KDM5B SLK TRIM25 ACVR1 RRAGC RPS6KC1 CSGALNACT2 PER2 CLCN6 MTUS1 CSNK1G1 RIPOR1 NOTCH1 HSP90AB1 MAP3K14 WDR47 PDE4DIP GMEB1 KDM4A OGA	1.92e-06	822	187	20	M6782
Coexpression	GSE17721_POLYIC_VS_CPG_6H_BMDC_UP	KDM5B ACVR1 RRAGC BMPR1A ATP8A1 BRDT PLCG2 OAS2 MTBP	1.44e-05	200	187	9	M3943
Coexpression	DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN	KDM5B CCNDBP1 ACVR1 ADGRV1 PCTP RPS6KC1 ATP8A1 DIAPH2 MAP4K4 MAP3K8 MAP3K14 NPHP3 FRMD6 NCOA7	1.70e-05	504	187	14	M2157
Coexpression	GSE11386_NAIVE_VS_MEMORY_BCELL_DN	KDM5B TRIM25 GRAMD1B ATP8A1 KCTD19 SPECC1L GPR183 ARRB1	1.87e-05	158	187	8	M372
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CORIN CADPS2 ACOXL	5.57e-09	183	186	10	6847c1252d6bb105524f812658112517fd351eab
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CORIN CADPS2 ACOXL	7.59e-09	189	186	10	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 NCOA7 CADPS2 ACOXL	9.27e-09	193	186	10	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 NCOA7 CADPS2 ACOXL	9.27e-09	193	186	10	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRTG ADGRV1 STK32A ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ ACOXL	1.12e-07	190	186	9	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.17e-07	191	186	9	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ CADPS2 ACOXL	1.17e-07	191	186	9	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	PRTG ADGRV1 STK32A ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ ACOXL	1.17e-07	191	186	9	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.23e-07	192	186	9	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	PRTG ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ZNF682 ACOXL	1.23e-07	192	186	9	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.23e-07	192	186	9	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.28e-07	193	186	9	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 NCOA7 PRKCZ CADPS2 ACOXL	1.34e-07	194	186	9	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.59e-07	198	186	9	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.59e-07	198	186	9	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ CADPS2 ACOXL	1.66e-07	199	186	9	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	9.35e-07	180	186	8	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	facs-Heart-LV-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX TRIM25 GRAMD1B BTLA GPR183 TSPAN32 N4BP2 PPP1R16B	1.02e-06	182	186	8	6dff753d65ba45db81f3cc0c9f59e1779d490955
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ADGRV1 BMP1 MTUS1 CCDC141 SNX25 PRKCZ CADPS2 ACOXL	1.06e-06	183	186	8	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRV1 BMPR1B ATP8A1 MTUS1 SNX25 PRKCZ CADPS2 ACOXL	1.20e-06	186	186	8	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RABEPK ERN1 ADGRV1 STK32A BMP1 ATP8A1 MTUS1 CADPS2	1.20e-06	186	186	8	e83718fabb057100835d3357df407f283d23fe16
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	ADGRV1 ATP8A1 MTUS1 HOMER2 PRKCZ CADPS2 ZNF682 ACOXL	1.24e-06	187	186	8	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ ZNF682 ACOXL	1.24e-06	187	186	8	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	NPAS3 FNDC3B COL6A2 LPAR1 TRIM9 UNC5C NCOA7 MUSK	1.40e-06	190	186	8	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	NPAS3 FNDC3B COL6A2 AOX1 LPAR1 UNC5C NCOA7 MUSK	1.58e-06	193	186	8	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.64e-06	194	186	8	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	FNDC1 COL6A2 MXRA5 LPAR1 FRMD6 UNC5C HAS2 MUSK	1.64e-06	194	186	8	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRTG ADGRV1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 ACOXL	1.77e-06	196	186	8	7e5addaa844e66f8160e05858c341866a80aed23
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BMP1 ATP8A1 MTUS1 CFI CCDC141 SNX25 PRKCZ ACOXL	1.77e-06	196	186	8	65e161fd672e37a5d10f28011bb422c4d7042d6a
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	BACE1 BMP1 FNDC1 COL6A2 MXRA5 CFI LPAR1 FRMD6	1.91e-06	198	186	8	e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ERN1 ADGRV1 STK32A BMP1 ATP8A1 MTUS1 CCDC141 CADPS2	1.91e-06	198	186	8	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ CADPS2 ACOXL	1.98e-06	199	186	8	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ CADPS2 ACOXL	1.98e-06	199	186	8	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRTG ADGRV1 ATP8A1 MTUS1 CFI CCDC141 SNX25 ACOXL	1.98e-06	199	186	8	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT2-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PRTG STARD10 ADGRV1 BMP1 MTUS1 CCDC141 SNX25 ACOXL	2.06e-06	200	186	8	65c83a3f6ee2a10bcb5b95076696232c6373a7b4
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT2-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PRTG STARD10 ADGRV1 BMP1 MTUS1 CCDC141 SNX25 ACOXL	2.06e-06	200	186	8	40e969883bc302e8fbc6b6ab9814529dc1472902
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-AT2-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	PRTG STARD10 ADGRV1 BMP1 MTUS1 CCDC141 SNX25 ACOXL	2.06e-06	200	186	8	ad9cdc82a647d379abc713a56db0e11bb6494106
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122\|Adult / Lineage, Cell type, age group and donor	ADGRV1 FCGBP ATP8A1 MTUS1 PRKCZ ZNF682 ACOXL	4.45e-06	157	186	7	31d1bd9138c60e8485664ec4144f987226e3eef9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRV1 BMPR1B ATP8A1 MTUS1 CADPS2 ZNF682 ACOXL	4.84e-06	159	186	7	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRV1 BMPR1B ATP8A1 MTUS1 PRKCZ ZNF682 ACOXL	7.51e-06	170	186	7	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ERN1 MALT1 BRDT FNDC3B PPP3CB PPP1R16B NCOA7	7.51e-06	170	186	7	adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	TRIM25 LONRF1 CEMIP2 BMP1 MLH3 ZBED6 ZNF415	9.77e-06	177	186	7	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRV1 MTUS1 HOMER2 PRKCZ CADPS2 ZNF682 ACOXL	1.01e-05	178	186	7	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD10 MALT1 BTLA GPR183 TSPAN32 TG PPP1R16B	1.13e-05	181	186	7	3510e0ecd4f098e8553946c44c2a49587d543755
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	ADGRV1 BMPR1B MTUS1 SNX25 NCOA7 CADPS2 ACOXL	1.13e-05	181	186	7	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ERN1 GRAMD1B PLCG2 MAP3K8 TSPAN32 PPP1R16B NCOA7	1.17e-05	182	186	7	6bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRTG ADGRV1 ATP8A1 MTUS1 CADPS2 ZNF682 ACOXL	1.26e-05	184	186	7	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	PRTG ADGRV1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.26e-05	184	186	7	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NPAS3 STK32A FNDC1 BMPR1B GRIA2 TRIM9 PDE4DIP	1.30e-05	185	186	7	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	PRTG ADGRV1 ATP8A1 MTUS1 CADPS2 ZNF682 ACOXL	1.30e-05	185	186	7	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRV1 ATP8A1 MTUS1 HOMER2 CADPS2 ZNF682 ACOXL	1.30e-05	185	186	7	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	ADGRV1 STK32A BMPR1B MTUS1 HOMER2 CADPS2 ACOXL	1.30e-05	185	186	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESRRG BMP1 FNDC1 HOMER2 LPAR1 HAS1 HAS2	1.30e-05	185	186	7	d5f5866924648a3c14e2596218fd548a31777aa3
ToppCell	IPF-Epithelial-ATII\|World / Disease state, Lineage and Cell class	BMP1 MTUS1 CCDC141 SNX25 PRKCZ CADPS2 ACOXL	1.35e-05	186	186	7	6a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ERN1 CEMIP2 BMP1 ATP8A1 CCDC141 SNX25 ACOXL	1.40e-05	187	186	7	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ERN1 ADGRV1 STK32A BMP1 ATP8A1 MTUS1 CADPS2	1.44e-05	188	186	7	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRTG NPAS3 BMPR1B TRPM3 MXRA5 SHCBP1 CADPS2	1.49e-05	189	186	7	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	BMP1 MTUS1 CCDC141 SNX25 PRKCZ CADPS2 ACOXL	1.55e-05	190	186	7	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NPAS3 STK32A FNDC1 BMPR1B MXRA5 GRIA2 TRIM9	1.60e-05	191	186	7	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	NPAS3 FNDC3B COL6A2 LPAR1 UNC5C NCOA7 MUSK	1.60e-05	191	186	7	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NPAS3 STK32A FNDC1 BMPR1B MXRA5 GRIA2 TRIM9	1.60e-05	191	186	7	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	ADGRV1 ATP8A1 MTUS1 SNX25 PRKCZ CADPS2 ACOXL	1.65e-05	192	186	7	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ ACOXL	1.65e-05	192	186	7	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B MTUS1 TRPM3 PLCG2 MXRA5 SHCBP1 CADPS2	1.65e-05	192	186	7	40f44ac4ab673ee6156abdd2074a60b9de3281ad
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	DIAPH2 COL6A2 AOX1 LPAR1 UNC5C NCOA7 MUSK	1.65e-05	192	186	7	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	ADGRV1 ATP8A1 MTUS1 SNX25 PRKCZ CADPS2 ACOXL	1.65e-05	192	186	7	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 CADPS2 ACOXL	1.65e-05	192	186	7	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRTG BMP1 MTUS1 CCDC141 SNX25 PRKCZ ACOXL	1.71e-05	193	186	7	ba484fa1f290a92ae02475a4c468b4ac840c133e
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	DIAPH2 FNDC3B COL6A2 LPAR1 UNC5C NCOA7 MUSK	1.77e-05	194	186	7	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A2 AOX1 LPAR1 UNC5C PDE4DIP TNS1 MUSK	1.77e-05	194	186	7	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ERN1 BMP1 ATP8A1 MTUS1 CCDC141 SNX25 ACOXL	1.77e-05	194	186	7	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	FNDC3B COL6A2 LPAR1 FRMD6 TRIM9 UNC5C MUSK	1.83e-05	195	186	7	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	DIAPH2 FNDC3B COL6A2 LPAR1 UNC5C NCOA7 MUSK	1.83e-05	195	186	7	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADGRV1 MTUS1 SNX25 NCOA7 PRKCZ CADPS2 ACOXL	1.83e-05	195	186	7	9406866f99555198a9be311fbd65751b70f35446
ToppCell	Bronchial-NucSeq-Stromal-Schwann-Schwann_nonmyelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LONRF1 STK32A HEPACAM BMPR1B LPAR1 TRIM9 DEPDC7	1.95e-05	197	186	7	4a7ff67bb0754e034e6f2a1bd34cde86ee3ef899
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	MAT1A BMP1 COL6A2 SPECC1L HAS2 TNS1 MUSK	2.02e-05	198	186	7	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell	distal-mesenchymal-Mesothelial\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HEPACAM FNDC1 MXRA5 AOX1 GRIA2 CFI HAS1	2.02e-05	198	186	7	52e3cb45472dd6db31ae533e9ea0c3b550f11496
ToppCell	distal-mesenchymal-Mesothelial-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HEPACAM FNDC1 MXRA5 AOX1 GRIA2 CFI HAS1	2.02e-05	198	186	7	431bf719ee5cce4c9e8b6b405819b67e98fad3ca
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FNDC1 BMPR1A COL6A2 MXRA5 FRMD6 UNC5C HAS2	2.02e-05	198	186	7	bc9c9f2c87282b5ef8514773e065d2a6b5dde338
ToppCell	distal-1-mesenchymal-Mesothelial\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HEPACAM FNDC1 COL6A2 MXRA5 CFI TRIM9 HAS1	2.08e-05	199	186	7	8dd5b411d2f1626830b77a1616cc3fb67dc59338
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 PRKCZ ACOXL	2.08e-05	199	186	7	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Mesothelial-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	COL6A2 MXRA5 KCTD19 AOX1 XPNPEP2 TRIM9 HAS2	2.08e-05	199	186	7	60a653100aff31f7f96796ff2ec634798bfb4b0d
ToppCell	Biopsy_Control_(H.)-Epithelial-AT2\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	PRTG STARD10 BMP1 MTUS1 CCDC141 SNX25 ACOXL	2.08e-05	199	186	7	5323d49d3be980605b3e609b7f03bddba6e50e8a
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FNDC3B COL6A2 MXRA5 AOX1 LPAR1 FRMD6 HAS2	2.08e-05	199	186	7	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ERN1 ADGRV1 ATP8A1 MTUS1 CCDC141 PPP1R10 CADPS2	2.15e-05	200	186	7	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	NPAS3 CEMIP2 BMPR1B NOS3 NOTCH1 MAP3K8 CTDP1	2.15e-05	200	186	7	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	STARD10 ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 ACOXL	2.15e-05	200	186	7	acc771a902cf2f060c3eb9aedb72a256f5778a6c
ToppCell	Parenchyma_COVID-19-Epithelial-TX-AT2-2\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	STARD10 ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 ACOXL	2.15e-05	200	186	7	ceb613ac6cdf0e3e6bb3f04d89034e18a524cefb
ToppCell	medial-mesenchymal-Adventitial_Fibroblast\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A2 AOX1 XPNPEP2 CFI TRIM9 HAS1 HAS2	2.15e-05	200	186	7	87a5a0c252c08ba10316c21f6a9d5244c4d98c74
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	NPAS3 CEMIP2 BMPR1B NOS3 NOTCH1 MAP3K8 CTDP1	2.15e-05	200	186	7	ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A2 MXRA5 AOX1 XPNPEP2 LPAR1 HAS1 HAS2	2.15e-05	200	186	7	6b48ddde83bc6c941d557844aa214d4d2c8e736d
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	STARD10 ADGRV1 ATP8A1 MTUS1 CCDC141 SNX25 ACOXL	2.15e-05	200	186	7	eb44d1f80ecaac3a022cd04ab16dc36151e45488
ToppCell	medial-2-mesenchymal-Adventitial_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A2 AOX1 XPNPEP2 CFI TRIM9 HAS1 HAS2	2.15e-05	200	186	7	6ccf44f10d2cee5f48b8f05bd9a1b94057184d56
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A2 AOX1 LPAR1 FRMD6 UNC5C HAS1 HAS2	2.15e-05	200	186	7	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	medial-mesenchymal-Adventitial_Fibroblast-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A2 AOX1 XPNPEP2 CFI TRIM9 HAS1 HAS2	2.15e-05	200	186	7	5ee1318a74ca28a81bd81c20c611de84c17636b0
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SETX CEMIP2 FCGBP RIPOR1 BTLA OGA	5.56e-05	159	186	6	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESRRG ADGRV1 CACNA1B KCTD19 MROH2A UNC5C	5.76e-05	160	186	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESRRG ADGRV1 CACNA1B KCTD19 MROH2A UNC5C	5.76e-05	160	186	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Severe-Lymphoid-NK-\|Severe / Condition, Lineage, Cell class and cell subclass	IFT140 MAT1A COL6A2 CUBN PPP1R16B TMEM102	5.76e-05	160	186	6	d276c6cb8317d5fb19e7b4fe5238abaf0272d4c6
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRV1 BMPR1B MTUS1 HOMER2 ZNF682 ACOXL	6.17e-05	162	186	6	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
Drug	alkylbenzene	MAT1A ACVR1 BMPR1A AOX1 CRAT ARRB1 TNS1	1.25e-06	67	186	7	CID000031237
Drug	fluorocitrate	ACLY HOMER2 GRM3 OGDH GSTCD	2.41e-06	27	186	5	CID000107647
Disease	cancer (implicated_via_orthology)	ERCC4 ESRRG PHC3 NOTCH1 HSP90AA4P HSP90AB1 HSP90AB3P DLL4 POLR2G FRMD6 TTI1	1.07e-06	268	184	11	DOID:162 (implicated_via_orthology)
Disease	lung large cell carcinoma (biomarker_via_orthology)	NOTCH1 DLL4	3.87e-05	2	184	2	DOID:4556 (biomarker_via_orthology)
Disease	lung small cell carcinoma (biomarker_via_orthology)	NOTCH1 DLL4	3.87e-05	2	184	2	DOID:5409 (biomarker_via_orthology)
Disease	Addicted to cocaine	PER2 GRM3	1.16e-04	3	184	2	C0858355
Disease	Gastric Adenocarcinoma	ERN1 BMPR1A BMPR1B BRDT	1.79e-04	45	184	4	C0278701
Disease	lung adenocarcinoma (biomarker_via_orthology)	NOTCH1 DLL4	2.30e-04	4	184	2	DOID:3910 (biomarker_via_orthology)
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5B KDM5A	2.30e-04	4	184	2	DOID:0060809 (implicated_via_orthology)
Disease	FANCONI ANEMIA, COMPLEMENTATION GROUP Q	ERCC4 XRCC4	2.30e-04	4	184	2	C3808988
Disease	Dwarfism	ERCC4 XRCC4 TG	4.96e-04	25	184	3	C0013336
Disease	Adams Oliver syndrome	NOTCH1 DLL4	5.71e-04	6	184	2	C0265268
Disease	Congenital defect of skull and scalp	NOTCH1 DLL4	5.71e-04	6	184	2	C2931779
Disease	Adams-Oliver syndrome 1	NOTCH1 DLL4	5.71e-04	6	184	2	C4551482
Disease	myotonic dystrophy type 1 (implicated_via_orthology)	SIX4 MBNL3	5.71e-04	6	184	2	DOID:11722 (implicated_via_orthology)
Disease	Adams-Oliver syndrome (is_implicated_in)	NOTCH1 DLL4	5.71e-04	6	184	2	DOID:0060227 (is_implicated_in)
Disease	limb ischemia (is_implicated_in)	NOS3 DLL4	5.71e-04	6	184	2	DOID:0050852 (is_implicated_in)
Disease	level of Sterol ester (27:1/22:6) in blood serum	FNDC3B MUSK	7.96e-04	7	184	2	OBA_2045201
Disease	platelet component distribution width	SPTA1 TRPM3 ATAD2B PLCG2 NOS3 DLL4 DOK2 CUBN TNN PPP1R16B DEPDC7 MUSK ACOXL	9.60e-04	755	184	13	EFO_0007984
Disease	cleft palate (implicated_via_orthology)	UFD1 SPECC1L	1.06e-03	8	184	2	DOID:674 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	KDM5B NSUN2 IRS4 KDM5A	1.26e-03	75	184	4	DOID:1059 (implicated_via_orthology)
Disease	hemangiopericytoma (is_marker_for)	NOTCH1 DLL4	1.35e-03	9	184	2	DOID:264 (is_marker_for)
Disease	PITUITARY DWARFISM I	ERCC4 XRCC4	1.35e-03	9	184	2	C0342573
Disease	egg allergy measurement	ERCC4 BMPR1B	1.35e-03	9	184	2	EFO_0007018
Disease	level of Phosphatidylcholine (16:0_22:4) in blood serum	MAP4K4 MUSK	1.35e-03	9	184	2	OBA_2045078
Disease	coronary artery disease	IFT140 SLK MAT2A BMP1 FNDC1 BMPR1B VPS33B TRPM3 PLCG2 NOS3 HOMER2 FNDC3B SPECC1L ZBED6 CSNK1G2 UNC5C TNS1	1.36e-03	1194	184	17	EFO_0001645
Disease	Nonsyndromic Deafness	ADGRV1 OTOGL HOMER2 KCNQ4	1.67e-03	81	184	4	C3711374
Disease	thiamine measurement	LPAR1 N4BP2	1.68e-03	10	184	2	EFO_0010540
Disease	response to carboplatin, response to antineoplastic agent	PRTG PLCG2	1.68e-03	10	184	2	GO_0097327, GO_0097328
Disease	alopecia areata (is_marker_for)	KDM5A KDM4A	1.68e-03	10	184	2	DOID:986 (is_marker_for)
Disease	trochanter bone mineral density	TRPM3 HSP90AB3P	1.68e-03	10	184	2	EFO_0020095
Disease	electrocardiography	SLK ESRRG CLCN6 TRPM3 FNDC3B DOK2 CCDC141 WDPCP KCNQ4 NCOA7	1.91e-03	530	184	10	EFO_0004327
Disease	mean platelet volume	SPTA1 STARD10 BACE1 PFKFB4 GRAMD1B TRPM3 ATAD2B RIPOR1 PLCG2 NOS3 FBXO34 NRDC DOK2 PPP1R16B MUSK	1.91e-03	1020	184	15	EFO_0004584
Disease	corneal resistance factor	PRTG CSGALNACT2 TRPM3 HSP90AB3P FNDC3B COL6A2 LPAR1 NPHP3 TNS1	2.19e-03	451	184	9	EFO_0010067
Disease	retinopathy of prematurity (biomarker_via_orthology)	NOTCH1 DLL4	2.45e-03	12	184	2	DOID:13025 (biomarker_via_orthology)
Disease	arachidonoylcarnitine (C20:4) measurement	SLC22A16 MUSK	2.45e-03	12	184	2	EFO_0800544
Disease	right ventricular stroke volume measurement	NOS3 CCDC141	2.45e-03	12	184	2	EFO_0021817
Disease	juvenile polyposis syndrome (implicated_via_orthology)	BMPR1A BMPR1B	2.88e-03	13	184	2	DOID:0050787 (implicated_via_orthology)
Disease	Connective Tissue Diseases	ACVR1 NOTCH1	2.88e-03	13	184	2	C0009782
Disease	Craniofacial Abnormalities	BMPR1A BMPR1B UFD1 NOTCH1 LPAR1	3.02e-03	156	184	5	C0376634
Disease	IGF-1 measurement	IFT140 TRIM66 PHC3 PLCG2 DENND5B FNDC3B OGDH NCOA7 ACOXL	3.69e-03	488	184	9	EFO_0004627
Disease	Alzheimer's Disease	BACE1 PLCG2 NOS3 UNC5C	3.73e-03	101	184	4	C0002395
Disease	pulmonary fibrosis (biomarker_via_orthology)	NOTCH1 HSP90AB1 HSP90AB3P	3.77e-03	50	184	3	DOID:3770 (biomarker_via_orthology)
Disease	cognitive inhibition measurement	ESRRG BMPR1B HSP90AA4P	3.77e-03	50	184	3	EFO_0007969
Disease	opioid dependence	ADGRV1 BMPR1B RIPOR1 PLCG2 CTDP1 CORIN	3.82e-03	237	184	6	EFO_0005611
Disease	delta-6 desaturase measurement	GRAMD1B MUSK	3.85e-03	15	184	2	EFO_0007765
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A MAT2A	3.85e-03	15	184	2	DOID:3146 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5B KDM5A	4.38e-03	16	184	2	DOID:0050888 (implicated_via_orthology)
Disease	level of triacylglycerol (56:6) in blood serum	ZNF682 MUSK	4.38e-03	16	184	2	OBA_2020007
Disease	colorectal mucinous adenocarcinoma	CCDC141 SLC22A16	4.38e-03	16	184	2	EFO_0009361
Disease	Pre-Eclampsia	NOS3 CORIN	4.38e-03	16	184	2	C0032914
Disease	Eye Abnormalities	BMPR1A BMPR1B	4.95e-03	17	184	2	C0015393
Disease	Kuhnt-Junius degeneration (is_implicated_in)	NOS3 CFI	4.95e-03	17	184	2	DOID:10873 (is_implicated_in)
Disease	Ciliopathies	ADGRV1 TCTN1 WDPCP NPHP3	5.06e-03	110	184	4	C4277690
Disease	acute pancreatitis	STK32A RADX	5.54e-03	18	184	2	EFO_1000652
Disease	C-X-C motif chemokine 16 measurement	CCR9 ACOXL	5.54e-03	18	184	2	EFO_0010911
Disease	Meckel syndrome type 1	WDPCP NPHP3	5.54e-03	18	184	2	C3714506
Disease	reticulocyte count	ACLY SPTA1 ACVR1 ATAD2B PLCG2 BAIAP3 FBXO34 HSP90AB1 FNDC3B COPB1 TSPAN32 SLC22A16 NCOA7 TNS1	6.07e-03	1045	184	14	EFO_0007986
Disease	blood metabolite measurement	CRAT SLC22A16	6.17e-03	19	184	2	EFO_0005664
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	XRCC4 MLH3	6.17e-03	19	184	2	C1333991
Disease	polycystic kidney disease (biomarker_via_orthology)	NOS3 DLL4	6.17e-03	19	184	2	DOID:0080322 (biomarker_via_orthology)
Disease	reasoning	ANKRD52 PRKCZ	6.17e-03	19	184	2	EFO_0004350
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	XRCC4 MLH3	6.17e-03	19	184	2	C2936783

Protein segments in the cluster

Peptide	Gene	Start	Entry
ESDMNCIEDTLLQYP	ACCSL	191	Q4AC99
SETMPLYTLCKEDLE	CTDP1	841	Q9Y5B0
VTLDMEDCGYNIPQT	BACE1	436	P56817
MIEAEEQQPCKTDFY	ADAL	1	Q6DHV7
DVVCYTQKADSPMDD	CFI	211	P05156
FEICPFESELNMDIA	BAIAP3	551	O94812
MQEGSEVYSNPCLEE	BTLA	236	Q7Z6A9
VESMPLCYIKTDITE	BRDT	381	Q58F21
EEYEPELCRQMTKTI	DYNLT5	96	Q8N7M0
SLTKVDEAEYMCPDG	GRM3	116	Q14832
YSQASELPTDAVDCM	FBXO34	421	Q9NWN3
EKLMCPQEIVDYIAD	NDUFAB1	136	O14561
YMAPEVLDETIQVDC	ACVR1	381	Q04771
ILDTEPEMDEYFVCT	ADGRV1	3156	Q8WXG9
SEDYASCSDMDLLNP	CEP44	306	Q9C0F1
SMDNLDSECSEVYQP	SPECC1L	341	Q69YQ0
PRDSMYQSVCLISEE	DLL4	661	Q9NR61
AETDVEEIYHPVMCT	EAPP	246	Q56P03
EEIYHPVMCTECSTE	EAPP	251	Q56P03
VCLDATMPRVSEDVY	CRAT	286	P43155
DCLEYLPDQMVVEIS	DEPDC7	271	Q96QD5
EMSFNCLEDVESTIP	ANKRD52	571	Q8NB46
YDDLCEPEQFGVVMS	DIAPH2	771	O60879
EMDIESQPECAYDHL	BMP1	791	P13497
VPSDPSYEDMREIVC	BMPR1B	431	O00238
RASCEALYSEMDPEE	CACNA1B	781	Q00975
TAQYKCPVAMEEADD	ARRB1	246	P49407
DFNTMGYCEEIPVEE	GRAMD1B	241	Q3KR37
EPQAMCYIETSNLDG	ATP8A1	176	Q9Y2Q0
EFVIDTPCENAEKMY	ACOXL	116	Q9NUZ1
EAIYCDDMPLVDQEL	AOX1	596	Q06278
TICQEEYSEAPNEMV	MTF2	106	Q9Y483
MNTEGEIYDDCIVTV	RABEPK	356	Q7Z6M1
MDTPLLDTEEEVHYC	KCTD19	161	Q17RG1
MVYSTCSLNPIEDEA	NSUN2	316	Q08J23
MYCPEDIRTSQIDTL	RADX	771	Q6NSI4
YCQPEEEVARLLTMA	DNAJC14	421	Q6Y2X3
FIMDSCDELIPEYLN	HSP90AB1	361	P08238
PNTDGMELLVCYEDE	MAP4K4	1126	O95819
PCMEENELYSSAVTV	DOK2	131	O60496
ADQDMECLSQYPSLS	PRAMEF17	306	Q5VTA0
YCTEDVDECQLMPNA	NOTCH1	291	P46531
EANEDMEIAYPITCG	GMEB1	86	Q9Y692
IMCDAYVTDFPLDLD	MALT1	626	Q9UDY8
ESAECLEMTYVPNID	MTUS1	646	Q9ULD2
MYCAPEVGAITEETE	RPS6KC1	966	Q96S38
RVFIMDSCDELIPEY	HSP90AB3P	301	Q58FF7
EVCMFSLAYGDIPEE	LONRF1	456	Q17RB8
YATDETEECMPLTIV	MAT2A	141	P31153
ETMYSELPEEVKCIF	ATAD2B	871	Q9ULI0
IIPQLMSECEYVSEK	HOMER2	276	Q9NSB8
EALCENFPEEMATYL	CSNK1G1	276	Q9HCP0
IEVLCENFPEEMATY	CSNK1G2	276	P78368
SYQCELTVDDIMPAV	KCNQ4	516	P56696
DIENCSNMAPLYSDS	LPAR1	191	Q92633
CPELLDQHYTVDMTE	HMGXB3	1141	Q12766
VIDIMENLYASEEPA	MAP3K8	26	P41279
ESTMNEYIEQRKPCD	GRIA2	726	P42262
CGADVPSYTVEEMES	PER2	166	O15055
QDVIFPLMCYTDADE	IPO7	351	O95373
VIQKMICEYSEEVTP	IPO7	561	O95373
ICEYSEEVTPIAVEM	IPO7	566	O95373
EYDVCMEPAKTLIEF	MLH3	316	Q9UHC1
DTPCNEMNTDTFLEE	NPEPL1	186	Q8NDH3
DIHIDIMDYIQPATC	COPB1	821	P53618
IMDYIQPATCTDAEF	COPB1	826	P53618
VCEEMTYEEIQDNYP	PFKFB4	331	Q16877
PKEDLSSEQYEMTEC	KDM4A	416	O75164
SSEQYEMTECPAALA	KDM4A	421	O75164
YATDETEECMPLTII	MAT1A	141	Q00266
VCVGVSPEMAEKEDY	KDM5B	1516	Q9UGL1
LTAYLPAMSEDDEDC	PDPK2P	331	Q6A1A2
MRPVLESEEELYSSC	PLCG2	1186	P16885
PYEECQTLIDEMVNT	OAS2	26	P29728
YQVEDVCEEEMPEES	PHC3	586	Q8NDX5
VGVSPEMAENEDYIC	KDM5A	1641	P29375
LPEMSEKCEVLQYSA	NDUFA10	246	O95299
FDPRVLCMDEYDVVS	NOS3	546	P29474
IPEDDAIYQCMAENS	PRTG	386	Q2VWP7
DEPTLDVIETCMAYQ	PPP1R16B	176	Q96T49
EGMYPSICVEATESL	PFN4	106	Q8NHR9
EDCSPTLLADIYMDS	PCTP	61	Q9UKL6
NSDDPEAVMYVCKVA	OGDH	476	Q02218
DLEPQDSCIMAYDGL	CUBN	1556	O60494
VSVDKEPMADSCIYE	WDPCP	306	O95876
ETESLHCEYVAEPVM	ERVK-10	126	P87889
ETESLHCEYVAEPVM	ERVK-19	126	Q9YNA8
ETESLHCEYVAEPVM	ERVK-24	126	P63145
ETESLHCEYVTEPVM	ERVK-5	126	Q9HDB9
ETESLHCEYVAEPVM	ERVK-8	126	P62685
ETESLHCEYVAEPVM	ERVK-9	126	P63126
ESLEVSPDMCIYITE	FRMD6	471	Q96NE9
ETESLHCEYVAEPVM	HERVK_113	126	P62684
MEAPSECYDAVNLIG	ADAM30	516	Q9UKF2
ADELTPEQYRMCIQS	CSGALNACT2	491	Q8N6G5
CINDPYLEVLETMDN	CLCN6	56	P51797
SNLSSVEMYDPETDC	KLHL18	536	O94889
LPEDMLSGEEYECVS	CCDC141	1196	Q6ZP82
EMLSEDCKENPTYTV	ERN1	741	O75460
MEQAVEECDPYSGLL	CCNDBP1	191	O95273
YTMVELCSEDDTLPA	FCGBP	496	Q9Y6R7
MAAYPESCVDTTVLD	FERD3L	1	Q96RJ6
CEVSEYSVEMTEPED	FNDC3B	701	Q53EP0
LIMSSNGIPECYAEE	FNDC1	1526	Q4ZHG4
STIVEDPQTKCEYML	ESRRG	106	P62508
EESGIAICTMVYPSD	CCR9	191	P51686
DPGLTECDVMTYVRE	COL6A2	586	P12110
DYVQVCDSDTMLDPA	HAS2	206	Q92819
VPSDPSYEDMREVVC	BMPR1A	461	P36894
AECPAITRMYEESAL	DENND5B	1226	Q6ZUT9
APNRIVYCTMEVEGE	CADPS2	381	Q86UW7
SMYQAEEFTLLPCSE	CEMIP2	441	Q9UHN6
DNQTCLMPDEYVEEC	CORIN	566	Q9Y5Q5
VQMEPSDSYEVLSCI	COPG2	676	Q9UBF2
DYVQVCDSDTRLDPM	HAS1	231	Q92839
IEASDNTVTICMDYI	MBNL3	206	Q9NUK0
DDDLYSCMVENPISQ	HEPACAM	211	Q14CZ8
VCGMLYTASNPEDET	ESCO1	621	Q5FWF5
RDLIMDNCEELIPEY	HSP90AA4P	171	Q58FG1
PYRCDLSNEEDILSM	DHRS11	66	Q6UWP2
ERVYEACMEAFDSLP	PPP3CB	181	P16298
ECGYSVQVISMEPES	GSTCD	606	Q8NEC7
LCETPVLAMHEENVY	IFT140	481	Q96RY7
LSDLPSCYMSDIEFE	MTBP	311	Q96DY7
TEIMYTLQEPIDCTC	OTOGL	2336	Q3ZCN5
LYPREDMEAVSLTCD	PSG3	156	Q16557
YDMEVPDSGIDLQCT	MAP3K14	911	Q99558
SPILALSCMDTYDIE	OR8H1	181	Q8NGG4
YVVDPFSECCMDISL	IRS4	1046	O14654
ITVTQYDPEEDCRKM	MUC17	4306	Q685J3
METDYVEALTPICIS	MROH2A	531	A6NES4
LHRIQYEMPLCDEES	SYPL2	86	Q5VXT5
CLTQFLEDEYPDMPT	MRPL44	136	Q9H9J2
ATDSSPVDMQSYELC	RRAGC	271	Q9HB90
YMVEIDILASCDHPN	SLK	76	Q9H2G2
RMECCDVPAETLYDV	STARD10	71	Q9Y365
EPDKCNIAVEEEYMT	NCOA7	51	Q8NI08
EDIETDVLYSPQMAL	OGA	366	O60502
RCYLIYTDETQPEMD	NPHP3	301	Q7Z494
EENGEQLPCYFVMVS	SNX25	521	Q9H3E2
VVEIPAYTFVCIAMD	SLC22A16	396	Q86VW1
AERITCMEYPNFEET	GPR183	176	P32249
SCLKTEIMSPLYQDE	FTSJ3	576	Q8IY81
AMTPDDLQEKEVAYC	POLR2B	676	P30876
YVLDGMVDTVCEDLE	SIX4	746	Q9UIU6
EPESYLDDMVTCSQI	SETX	341	Q7Z333
CENRISDYMDLTPVD	NPAS3	346	Q8IXF0
EPYLCDSQVSTFTME	SHCBP1	146	Q8NEM2
NCDPTFELEEMILES	STK32A	306	Q8WU08
TYVPCLKTLQEEVME	MRPL24	186	Q96A35
DSCDPYFMLNNVTEI	SLC12A4	351	Q9UP95
ETESLHCEYVAEPVM	ERVK-9	126	P63128
DYVCSRDEPSVAAMV	ACLY	516	P53396
LETLQSVRPCFMDEY	CLUAP1	231	Q96AJ1
SVRPCFMDEYEKTEE	CLUAP1	236	Q96AJ1
MLENTECHSIYEESP	WDR47	361	O94967
PCYKTMDEDIVIQQD	POLR2G	126	P62487
DPMEEDILQVVKYCT	REV1	1181	Q9UBZ9
DASRPLQVYCDMETD	TNN	1091	Q9UQP3
PEYDDCMFSRVLTLD	SMC1B	1201	Q8NDV3
EFPDYCTPEVTEMIA	SOX12	286	O15370
PTQVEDAMLDTYDLV	TSPAN32	116	Q96QS1
PSSCIDIYVSAMDEL	TRPM3	1421	Q9HCF6
ALSECYTVASVAEMP	TRIM25	471	Q14258
AICSEMTADRDPVYD	XRCC4	216	Q13426
TMEDSCELDLVYVTE	TNS1	6	Q9HBL0
MASAELDYTIEIPDQ	TMEM53	1	Q6P2H8
CEEIEALSMAFYSSP	TCTN1	256	Q2MV58
DLESCYAQVCLPEMV	TMEM102	136	Q8N9M5
YTEDLLPEQCMQDSF	ZNF682	81	O95780
QVAEPEACDQMYESL	UQCC2	46	Q9BRT2
QEQTDPVEYVENMCE	NRDC	556	O43847
ISEMLPTACDESYKD	SPTA1	1516	P02549
NMTVTDPEACYIGTE	PBK	196	Q96KB5
CEPEDYVVVSTEMQS	ATIC	146	P31939
VDPETRYMSLAVCEL	WDR6	856	Q9NNW5
LMEYCLEVIKENDPS	TRIM9	366	Q9C026
SIIECDMNVDFDAPL	UFD1	181	Q92890
AEEVCNYMESSPEIC	ZBED6	796	P86452
MPELYTEDFIQGCDV	ZNF415	1	Q09FC8
EDPETCLQLNMVYQE	SNAPC4	81	Q5SXM2
GPMCVQIEDYSQVRD	XPNPEP2	296	O43895
LEVGDYILTPEMCVE	ERCC4	711	Q92889
AEERMCYQCESEDEP	VEZT	686	Q9HBM0
TTDSPLYEECVRMND	TRMT10B	171	Q6PF06
QAVRYSLCSEESPEM	VRTN	131	Q9H8Y1
SLTQPEMEYDCENAC	TRIM66	1016	O15016
YTESMCLLESELEAQ	RIPOR1	191	Q6ZS17
PLDEECSMDETPYVE	PPP1R10	521	Q96QC0
LYPEAQVCDDIMESN	TG	1921	P01266
LCMQTAPDSDDVALY	UNC5C	366	O95185
LCMEEYVIEPKSVQF	TOE1	126	Q96GM8
SPQKFYACEMVLEEE	VPS33B	116	Q9H267
YLVTCLETEEMGEEL	TTI1	571	O43156
DPCTVSSQMELEEAF	PRKCZ	66	Q05513
DINATVALDFECPMT	MXRA5	356	Q9NR99
VALDFECPMTRENYE	MXRA5	361	Q9NR99
VEEVATFMCAVESYP	MUSK	41	O15146
LDPDVVYLMLSECDF	N4BP2	61	Q86UW6
ELEACSDMDIVSEYT	PDE4DIP	1616	Q5VU43
EMAVCPEQLSEFLDS	NECAB2	291	Q7Z6G3
MATELEYESVLCVKP	NECAP1	1	Q8NC96
MEESGYESVLCVKPD	NECAP2	1	Q9NVZ3