Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEE POTEF POTEI	3.98e-06	11	59	3	GO:0098973
GeneOntologyMolecularFunction	type III transforming growth factor beta receptor binding	TGFB1 TGFB2	5.13e-05	4	59	2	GO:0034714
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR1 TLR6	5.13e-05	4	59	2	GO:0035663
GeneOntologyMolecularFunction	structural constituent of postsynapse	POTEE POTEF POTEI	1.14e-04	32	59	3	GO:0099186
GeneOntologyMolecularFunction	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	SYNJ2 INPP5J	1.79e-04	7	59	2	GO:0052659
GeneOntologyMolecularFunction	inositol-1,4,5-trisphosphate 5-phosphatase activity	SYNJ2 INPP5J	2.38e-04	8	59	2	GO:0052658
GeneOntologyMolecularFunction	structural constituent of synapse	POTEE POTEF POTEI	2.59e-04	42	59	3	GO:0098918
GeneOntologyMolecularFunction	inositol tetrakisphosphate phosphatase activity	SYNJ2 INPP5J	3.05e-04	9	59	2	GO:0052743
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	SYNJ2 INPP5J	3.80e-04	10	59	2	GO:0004439
GeneOntologyMolecularFunction	lipopeptide binding	TLR1 TLR6	3.80e-04	10	59	2	GO:0071723
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate phosphatase activity	SYNJ2 INPP5J	5.56e-04	12	59	2	GO:0106019
GeneOntologyMolecularFunction	type II transforming growth factor beta receptor binding	TGFB1 TGFB2	5.56e-04	12	59	2	GO:0005114
GeneOntologyMolecularFunction	lipid binding	COMP OSBPL3 CYTH1 DOK7 TLR1 OSBPL7 OSBPL6 AKT1 TLR6 MCOLN3	5.79e-04	988	59	10	GO:0008289
GeneOntologyMolecularFunction	steroid binding	COMP OSBPL3 OSBPL7 OSBPL6	6.45e-04	133	59	4	GO:0005496
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 5-phosphatase activity	SYNJ2 INPP5J	6.56e-04	13	59	2	GO:0034595
GeneOntologyMolecularFunction	cholesterol binding	OSBPL3 OSBPL7 OSBPL6	6.74e-04	58	59	3	GO:0015485
GeneOntologyMolecularFunction	inositol trisphosphate phosphatase activity	SYNJ2 INPP5J	7.63e-04	14	59	2	GO:0046030
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	TLR1 TLR6	1.00e-03	16	59	2	GO:0061809
GeneOntologyMolecularFunction	sterol binding	OSBPL3 OSBPL7 OSBPL6	1.21e-03	71	59	3	GO:0032934
GeneOntologyMolecularFunction	inositol phosphate phosphatase activity	SYNJ2 INPP5J	1.58e-03	20	59	2	GO:0052745
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	SYNJ2 INPP5J	2.87e-03	27	59	2	GO:0034593
GeneOntologyMolecularFunction	Toll-like receptor binding	TLR1 TLR6	3.31e-03	29	59	2	GO:0035325
GeneOntologyMolecularFunction	alcohol binding	OSBPL3 OSBPL7 OSBPL6	3.42e-03	102	59	3	GO:0043178
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	SYNJ2 INPP5J	3.54e-03	30	59	2	GO:0052866
GeneOntologyMolecularFunction	transforming growth factor beta receptor binding	TGFB1 TGFB2	3.78e-03	31	59	2	GO:0005160
GeneOntologyMolecularFunction	protein kinase binding	POTEE NBEAL1 POTEF DOK7 AKT1 AKT2 POTEI NOS2	3.97e-03	873	59	8	GO:0019901
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-19 ERVK-25	5.35e-03	37	59	2	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-19 ERVK-25	5.64e-03	38	59	2	GO:0070001
GeneOntologyBiologicalProcess	detection of bacterial lipopeptide	TLR1 TLR6	2.33e-05	3	58	2	GO:0070340
GeneOntologyBiologicalProcess	negative regulation of long-chain fatty acid import across plasma membrane	AKT1 AKT2	4.65e-05	4	58	2	GO:0010748
GeneOntologyBiologicalProcess	detection of bacterial lipoprotein	TLR1 TLR6	4.65e-05	4	58	2	GO:0042494
GeneOntologyBiologicalProcess	negative regulation of long-chain fatty acid import into cell	AKT1 AKT2	4.65e-05	4	58	2	GO:0140213
GeneOntologyBiologicalProcess	postsynaptic actin cytoskeleton organization	POTEE POTEF POTEI	8.97e-05	31	58	3	GO:0098974
GeneOntologyBiologicalProcess	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	TGFB1 TGFB2	1.16e-04	6	58	2	GO:1905005
GeneOntologyBiologicalProcess	postsynaptic cytoskeleton organization	POTEE POTEF POTEI	1.30e-04	35	58	3	GO:0099188
GeneOntologyBiologicalProcess	regulation of long-chain fatty acid import across plasma membrane	AKT1 AKT2	1.62e-04	7	58	2	GO:0010746
GeneOntologyBiologicalProcess	cellular response to low-density lipoprotein particle stimulus	TGFB1 AKT1 TLR6	1.79e-04	39	58	3	GO:0071404
GeneOntologyBiologicalProcess	bile acid biosynthetic process	OSBPL3 OSBPL7 OSBPL6	1.94e-04	40	58	3	GO:0006699
GeneOntologyBiologicalProcess	response to lipoprotein particle	TGFB1 AKT1 TLR6	1.94e-04	40	58	3	GO:0055094
GeneOntologyBiologicalProcess	replication-born double-strand break repair via sister chromatid exchange	RAD21L1 RAD21	2.15e-04	8	58	2	GO:1990414
GeneOntologyBiologicalProcess	cellular response to lipoprotein particle stimulus	TGFB1 AKT1 TLR6	2.40e-04	43	58	3	GO:0071402
GeneOntologyBiologicalProcess	postsynapse organization	POTEE POTEF DOK7 LAMA5 AKT1 POTEI	2.43e-04	313	58	6	GO:0099173
GeneOntologyBiologicalProcess	peripheral nervous system myelin maintenance	AKT1 AKT2	2.76e-04	9	58	2	GO:0032287
GeneOntologyBiologicalProcess	regulation of long-chain fatty acid import into cell	AKT1 AKT2	2.76e-04	9	58	2	GO:0140212
GeneOntologyBiologicalProcess	nitric oxide biosynthetic process	AKT1 AKT2 TLR6 NOS2	2.79e-04	112	58	4	GO:0006809
GeneOntologyBiologicalProcess	regulation of polysaccharide biosynthetic process	TGFB1 AKT1 AKT2	3.13e-04	47	58	3	GO:0032885
GeneOntologyBiologicalProcess	cellular response to bacterial lipoprotein	TLR1 TLR6	3.45e-04	10	58	2	GO:0071220
GeneOntologyBiologicalProcess	cellular response to bacterial lipopeptide	TLR1 TLR6	3.45e-04	10	58	2	GO:0071221
GeneOntologyBiologicalProcess	response to bacterial lipopeptide	TLR1 TLR6	3.45e-04	10	58	2	GO:0070339
GeneOntologyBiologicalProcess	nitric oxide metabolic process	AKT1 AKT2 TLR6 NOS2	3.74e-04	121	58	4	GO:0046209
GeneOntologyBiologicalProcess	positive regulation of interleukin-6 production	TGFB1 TLR1 TLR6 NOS2	3.86e-04	122	58	4	GO:0032755
GeneOntologyBiologicalProcess	reactive nitrogen species metabolic process	AKT1 AKT2 TLR6 NOS2	3.98e-04	123	58	4	GO:2001057
GeneOntologyBiologicalProcess	negative regulation of fatty acid transport	AKT1 AKT2	4.21e-04	11	58	2	GO:2000192
GeneOntologyBiologicalProcess	response to bacterial lipoprotein	TLR1 TLR6	4.21e-04	11	58	2	GO:0032493
GeneOntologyBiologicalProcess	bile acid metabolic process	OSBPL3 OSBPL7 OSBPL6	4.99e-04	55	58	3	GO:0008206
GeneOntologyBiologicalProcess	long-chain fatty acid import across plasma membrane	AKT1 AKT2	5.04e-04	12	58	2	GO:0015911
GeneOntologyBiologicalProcess	regulation of polysaccharide metabolic process	TGFB1 AKT1 AKT2	5.83e-04	58	58	3	GO:0032881
GeneOntologyBiologicalProcess	regulation of toll-like receptor 2 signaling pathway	TLR1 TLR6	5.94e-04	13	58	2	GO:0034135
GeneOntologyBiologicalProcess	T cell homeostasis	TGFB1 TGFB2 AKT1	6.13e-04	59	58	3	GO:0043029
GeneOntologyBiologicalProcess	regulation of cardiac epithelial to mesenchymal transition	TGFB1 TGFB2	6.92e-04	14	58	2	GO:0062042
GeneOntologyBiologicalProcess	negative regulation of macrophage cytokine production	TGFB1 TGFB2	6.92e-04	14	58	2	GO:0010936
GeneOntologyBiologicalProcess	cellular response to oxidised low-density lipoprotein particle stimulus	AKT1 TLR6	6.92e-04	14	58	2	GO:0140052
GeneOntologyCellularComponent	H4 histone acetyltransferase complex	POTEE POTEF POTEI HCFC1	8.37e-06	45	60	4	GO:1902562
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	OSBPL3 OSBPL7 OSBPL6	7.79e-05	29	60	3	GO:0097038
GeneOntologyCellularComponent	NuA4 histone acetyltransferase complex	POTEE POTEF POTEI	1.05e-04	32	60	3	GO:0035267
GeneOntologyCellularComponent	H4/H2A histone acetyltransferase complex	POTEE POTEF POTEI	1.05e-04	32	60	3	GO:0043189
GeneOntologyCellularComponent	histone acetyltransferase complex	POTEE POTEF POTEI HCFC1	1.54e-04	94	60	4	GO:0000123
GeneOntologyCellularComponent	meiotic cohesin complex	RAD21L1 RAD21	1.69e-04	7	60	2	GO:0030893
GeneOntologyCellularComponent	protein acetyltransferase complex	POTEE POTEF POTEI HCFC1	2.28e-04	104	60	4	GO:0031248
GeneOntologyCellularComponent	ruffle membrane	SYNJ2 AKT2 FGD5 INPP5J	2.63e-04	108	60	4	GO:0032587
GeneOntologyCellularComponent	acetyltransferase complex	POTEE POTEF POTEI HCFC1	2.72e-04	109	60	4	GO:1902493
GeneOntologyCellularComponent	cohesin complex	RAD21L1 RAD21	4.38e-04	11	60	2	GO:0008278
GeneOntologyCellularComponent	phagocytic vesicle membrane	SLC15A2 TLR1 TLR6	1.75e-03	83	60	3	GO:0030670
GeneOntologyCellularComponent	ruffle	SYNJ2 AKT2 FGD5 INPP5J	2.90e-03	206	60	4	GO:0001726
GeneOntologyCellularComponent	leading edge membrane	SYNJ2 AKT2 FGD5 INPP5J	3.11e-03	210	60	4	GO:0031256
Domain	ANK	POTEB3 POTEE TRANK1 POTEM POTEF POTEG POTED ANKRD30A POTEI POTEB2 POTEH POTEB POTEC	7.99e-13	251	59	13	SM00248
Domain	ANK_REPEAT	POTEB3 POTEE TRANK1 POTEM POTEF POTEG POTED ANKRD30A POTEI POTEB2 POTEH POTEB POTEC	8.84e-13	253	59	13	PS50088
Domain	ANK_REP_REGION	POTEB3 POTEE TRANK1 POTEM POTEF POTEG POTED ANKRD30A POTEI POTEB2 POTEH POTEB POTEC	9.30e-13	254	59	13	PS50297
Domain	Ankyrin_rpt	POTEB3 POTEE TRANK1 POTEM POTEF POTEG POTED ANKRD30A POTEI POTEB2 POTEH POTEB POTEC	1.38e-12	262	59	13	IPR002110
Domain	Ankyrin_rpt-contain_dom	POTEB3 POTEE TRANK1 POTEM POTEF POTEG ANKRD30A POTEI POTEB2 POTEH POTEB POTEC	1.96e-11	254	59	12	IPR020683
Domain	-	POTEB3 POTEE TRANK1 POTEM POTEF POTEG ANKRD30A POTEI POTEB2 POTEH POTEC	2.89e-10	248	59	11	1.25.40.20
Domain	Ank_2	POTEB3 POTEE POTEM POTEF POTEG ANKRD30A POTEI POTEB2 POTEH POTEC	1.27e-09	215	59	10	PF12796
Domain	Ank	POTEE POTEM POTEF POTEG POTED ANKRD30A POTEI POTEH POTEB POTEC	2.25e-09	228	59	10	PF00023
Domain	PH	OSBPL3 CYTH1 DOK7 OSBPL7 OSBPL6 AKT1 AKT2 FGD5 ARHGAP27	2.07e-07	278	59	9	SM00233
Domain	PH_DOMAIN	OSBPL3 CYTH1 DOK7 OSBPL7 OSBPL6 AKT1 AKT2 FGD5 ARHGAP27	2.13e-07	279	59	9	PS50003
Domain	PH_domain	OSBPL3 CYTH1 DOK7 OSBPL7 OSBPL6 AKT1 AKT2 FGD5 ARHGAP27	2.19e-07	280	59	9	IPR001849
Domain	PH	OSBPL3 CYTH1 OSBPL7 OSBPL6 AKT1 AKT2 FGD5 ARHGAP27	5.85e-07	229	59	8	PF00169
Domain	PH_dom-like	NBEAL1 OSBPL3 CYTH1 DOK7 OSBPL7 OSBPL6 AKT1 AKT2 FGD5 ARHGAP27	7.94e-07	426	59	10	IPR011993
Domain	-	OSBPL3 CYTH1 DOK7 OSBPL7 OSBPL6 AKT1 AKT2 FGD5 ARHGAP27	3.51e-06	391	59	9	2.30.29.30
Domain	Oxysterol_BP	OSBPL3 OSBPL7 OSBPL6	6.46e-06	12	59	3	PF01237
Domain	Oxysterol-bd	OSBPL3 OSBPL7 OSBPL6	6.46e-06	12	59	3	IPR000648
Domain	Oxysterol-bd_CS	OSBPL3 OSBPL7 OSBPL6	6.46e-06	12	59	3	IPR018494
Domain	OSBP	OSBPL3 OSBPL7 OSBPL6	6.46e-06	12	59	3	PS01013
Domain	Actin_CS	POTEE POTEF POTEI	1.63e-05	16	59	3	IPR004001
Domain	ACTINS_2	POTEE POTEF POTEI	1.97e-05	17	59	3	PS00432
Domain	Actin/actin-like_CS	POTEE POTEF POTEI	2.36e-05	18	59	3	IPR020902
Domain	ACTINS_ACT_LIKE	POTEE POTEF POTEI	2.80e-05	19	59	3	PS01132
Domain	Rad21/Rec8_C_eu	RAD21L1 RAD21	2.94e-05	3	59	2	IPR006909
Domain	Rad21_Rec8_N	RAD21L1 RAD21	2.94e-05	3	59	2	IPR006910
Domain	-	RAD21L1 RAD21	2.94e-05	3	59	2	1.10.10.580
Domain	Rad21/Rec8_C	RAD21L1 RAD21	2.94e-05	3	59	2	IPR023093
Domain	Rad21_Rec8_N	RAD21L1 RAD21	2.94e-05	3	59	2	PF04825
Domain	Rad21_Rec8	RAD21L1 RAD21	2.94e-05	3	59	2	PF04824
Domain	TGF-beta	TGFB1 TGFB2	2.94e-05	3	59	2	IPR016319
Domain	Toll-like_receptor	TLR1 TLR6	9.75e-05	5	59	2	IPR017241
Domain	Actin	POTEE POTEF POTEI	1.26e-04	31	59	3	IPR004000
Domain	Actin	POTEE POTEF POTEI	1.26e-04	31	59	3	PF00022
Domain	ACTIN	POTEE POTEF POTEI	1.26e-04	31	59	3	SM00268
Domain	IPPc	SYNJ2 INPP5J	4.34e-04	10	59	2	IPR000300
Domain	IPPc	SYNJ2 INPP5J	4.34e-04	10	59	2	SM00128
Domain	TIR	TLR1 TLR6	1.98e-03	21	59	2	SM00255
Domain	TIR	TLR1 TLR6	2.18e-03	22	59	2	PF01582
Domain	-	TLR1 TLR6	2.38e-03	23	59	2	3.40.50.10140
Domain	TIR	TLR1 TLR6	2.59e-03	24	59	2	PS50104
Domain	TIR_dom	TLR1 TLR6	2.81e-03	25	59	2	IPR000157
Domain	-	SYNJ2 INPP5J	3.04e-03	26	59	2	3.60.10.10
Domain	Exo_endo_phos	SYNJ2 INPP5J	3.04e-03	26	59	2	PF03372
Domain	Endo/exonuclease/phosphatase	SYNJ2 INPP5J	3.27e-03	27	59	2	IPR005135
Domain	-	COMP NBEAL1 LAMA5	3.37e-03	95	59	3	2.60.120.200
Domain	TGFb_propeptide	TGFB1 TGFB2	3.52e-03	28	59	2	PF00688
Domain	TGF-b_N	TGFB1 TGFB2	3.52e-03	28	59	2	IPR001111
Domain	TGF-beta-rel	TGFB1 TGFB2	4.58e-03	32	59	2	IPR015615
Domain	LRRCT	TLR1 TLR6	4.58e-03	32	59	2	PF01463
Domain	TGFb_CS	TGFB1 TGFB2	4.58e-03	32	59	2	IPR017948
Domain	TGFB	TGFB1 TGFB2	6.09e-03	37	59	2	SM00204
Domain	TGF_BETA_2	TGFB1 TGFB2	6.09e-03	37	59	2	PS51362
Domain	Pkinase_C	AKT1 AKT2	6.09e-03	37	59	2	IPR017892
Domain	TGF_beta	TGFB1 TGFB2	6.09e-03	37	59	2	PF00019
Domain	TGF-b_C	TGFB1 TGFB2	6.09e-03	37	59	2	IPR001839
Domain	TGF_BETA_1	TGFB1 TGFB2	6.09e-03	37	59	2	PS00250
Domain	Pkinase_C	AKT1 AKT2	7.79e-03	42	59	2	PF00433
Domain	AGC-kinase_C	AKT1 AKT2	1.35e-02	56	59	2	IPR000961
Domain	AGC_KINASE_CTER	AKT1 AKT2	1.35e-02	56	59	2	PS51285
Domain	S_TK_X	AKT1 AKT2	1.35e-02	56	59	2	SM00133
Pathway	WP_TRANSCRIPTION_FACTORS_REGULATE_MIRNAS_RELATED_TO_CARDIAC_HYPERTROPHY	TGFB1 AKT1 AKT2	5.72e-06	15	34	3	M39431
Pathway	KEGG_COLORECTAL_CANCER	TGFB1 TGFB2 AKT1 AKT2	1.42e-05	62	34	4	M14631
Pathway	WP_SILDENAFIL_TREATMENT	AKT1 AKT2 NOS2	2.20e-05	23	34	3	M46455
Pathway	KEGG_RENAL_CELL_CARCINOMA	TGFB1 TGFB2 AKT1 AKT2	2.31e-05	70	34	4	M13266
Pathway	KEGG_PANCREATIC_CANCER	TGFB1 TGFB2 AKT1 AKT2	2.31e-05	70	34	4	M9726
Pathway	KEGG_CHRONIC_MYELOID_LEUKEMIA	TGFB1 TGFB2 AKT1 AKT2	2.73e-05	73	34	4	M321
Pathway	WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER	TGFB1 TGFB2 AKT1 AKT2	2.73e-05	73	34	4	M39758
Pathway	REACTOME_ECM_PROTEOGLYCANS	TGFB1 TGFB2 COMP LAMA5	3.20e-05	76	34	4	M27219
Pathway	WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS	TGFB1 TGFB2 AKT1	4.49e-05	29	34	3	M39516
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	LAMA5 AKT1 AKT2 NOS2	4.75e-05	84	34	4	M3228
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_NKX3_1_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.62e-05	5	34	2	M48999
Pathway	WP_PANCREATIC_ADENOCARCINOMA_PATHWAY	TGFB1 TGFB2 AKT1 AKT2	5.96e-05	89	34	4	M39732
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	OSBPL3 OSBPL7 OSBPL6	6.66e-05	33	34	3	M5967
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	OSBPL3 OSBPL7 OSBPL6	6.66e-05	33	34	3	MM14737
Pathway	WP_SMALL_CELL_LUNG_CANCER	LAMA5 AKT1 AKT2 NOS2	8.01e-05	96	34	4	M39834
Pathway	KEGG_MEDICUS_REFERENCE_MAGI_PTEN_SIGNALING_PATHWAY	AKT1 AKT2	8.42e-05	6	34	2	M47523
Pathway	WP_NEOVASCULARIZATION_PROCESSES	TGFB1 TGFB2 AKT1	9.42e-05	37	34	3	M39506
Pathway	KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	TLR1 AKT1 AKT2 TLR6	1.01e-04	102	34	4	M3261
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING	TLR1 AKT1 AKT2 TLR6	1.05e-04	103	34	4	M39434
Pathway	KEGG_PATHWAYS_IN_CANCER	TGFB1 TGFB2 LAMA5 AKT1 AKT2 NOS2	1.12e-04	325	34	6	M12868
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.18e-04	7	34	2	M47407
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.18e-04	7	34	2	M47790
Pathway	REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING	TGFB1 LAMA5 AKT1 NOS2	1.41e-04	111	34	4	M27609
Pathway	WP_BURN_WOUND_HEALING	TGFB2 TLR1 AKT1 TLR6	1.51e-04	113	34	4	M42571
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47399
Pathway	REACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING	TGFB1 TGFB2	1.57e-04	8	34	2	M48252
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47394
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47395
Pathway	REACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING	TGFB1 TGFB2	1.57e-04	8	34	2	MM17233
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47404
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47405
Pathway	KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY	TGFB1 TGFB2	1.57e-04	8	34	2	M47415
Pathway	KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA	TGFB1 TGFB2	1.57e-04	8	34	2	M47850
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47803
Pathway	REACTOME_RUNX2_REGULATES_GENES_INVOLVED_IN_CELL_MIGRATION	AKT1 AKT2	1.57e-04	8	34	2	M27806
Pathway	KEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47482
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47498
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.57e-04	8	34	2	M47715
Pathway	REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM	OSBPL3 OSBPL7 OSBPL6	1.59e-04	44	34	3	M499
Pathway	REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM	OSBPL3 OSBPL7 OSBPL6	1.70e-04	45	34	3	MM14751
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47397
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47392
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47391
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47402
Pathway	KEGG_MEDICUS_REFERENCE_HIF_1_SIGNALING_PATHWAY	TGFB1 TGFB2	2.01e-04	9	34	2	M47421
Pathway	KEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47802
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47490
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47481
Pathway	REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING	AKT1 AKT2	2.01e-04	9	34	2	MM15666
Pathway	KEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.01e-04	9	34	2	M47972
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.51e-04	10	34	2	M47400
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.51e-04	10	34	2	M47401
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	2.51e-04	10	34	2	M47615
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	AKT1 AKT2	2.51e-04	10	34	2	M27095
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	AKT1 AKT2	2.51e-04	10	34	2	MM14778
Pathway	WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER	TGFB2 AKT1 AKT2	2.92e-04	54	34	3	M42568
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.06e-04	11	34	2	M47797
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.06e-04	11	34	2	M47403
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.06e-04	11	34	2	M47406
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.06e-04	11	34	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.06e-04	11	34	2	M47499
Pathway	KEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.06e-04	11	34	2	M47756
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	AKT1 AKT2	3.06e-04	11	34	2	M47791
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.06e-04	11	34	2	M47501
Pathway	WP_CARDIAC_HYPERTROPHIC_RESPONSE	TGFB1 AKT1 AKT2	3.09e-04	55	34	3	M39685
Pathway	WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA	TGFB1 AKT1 NOS2	3.26e-04	56	34	3	M39413
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	3.67e-04	12	34	2	M47393
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350	AKT1 AKT2	3.67e-04	12	34	2	M47798
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	AKT1 AKT2	3.67e-04	12	34	2	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	AKT1 AKT2	3.67e-04	12	34	2	M47559
Pathway	REACTOME_SARS_COV_2_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS	AKT1 AKT2	3.67e-04	12	34	2	M45022
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	AKT1 AKT2	3.67e-04	12	34	2	MM15657
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	AKT1 AKT2	3.67e-04	12	34	2	M27939
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	AKT1 AKT2	3.67e-04	12	34	2	MM14777
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	AKT1 AKT2	3.67e-04	12	34	2	MM14550
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	4.33e-04	13	34	2	M47398
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	4.33e-04	13	34	2	M47603
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	AKT1 AKT2	4.33e-04	13	34	2	M549
Pathway	WP_HEPATITIS_B_INFECTION	TGFB1 TGFB2 AKT1 AKT2	4.57e-04	151	34	4	M39801
Pathway	WP_ENDOCHONDRAL_OSSIFICATION_WITH_SKELETAL_DYSPLASIAS	TGFB1 TGFB2 AKT1	4.61e-04	63	34	3	M39884
Pathway	WP_ENDOCHONDRAL_OSSIFICATION	TGFB1 TGFB2 AKT1	4.61e-04	63	34	3	M39646
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.05e-04	14	34	2	M47390
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_VHL_TO_HIF_1_SIGNALING_PATHWAY	TGFB1 TGFB2	5.05e-04	14	34	2	M47422
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	AKT1 AKT2	5.05e-04	14	34	2	MM15341
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	AKT1 AKT2	5.05e-04	14	34	2	M27638
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT1 AKT2	5.05e-04	14	34	2	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT1 AKT2	5.05e-04	14	34	2	M47536
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	AKT1 AKT2	5.05e-04	14	34	2	M3862
Pathway	WP_ENDOCHONDRAL_OSSIFICATION	TGFB1 TGFB2 AKT1	5.29e-04	66	34	3	MM15875
Pathway	WP_PLEURAL_MESOTHELIOMA	TGFB1 LAMA5 AKT1 AKT2 PRSS23 HCFC1	5.65e-04	439	34	6	M42563
Pathway	WP_MAPK_SIGNALING_PATHWAY	TGFB1 TGFB2 AKT1 AKT2	5.68e-04	160	34	4	MM15990
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.81e-04	15	34	2	M47389
Pathway	SA_MMP_CYTOKINE_CONNECTION	TGFB1 TGFB2	5.81e-04	15	34	2	M11736
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.81e-04	15	34	2	M47663
Pathway	REACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA	AKT1 AKT2	5.81e-04	15	34	2	M26902
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.81e-04	15	34	2	M47475
Pathway	WP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS	AKT1 AKT2	5.81e-04	15	34	2	M48306
Pathway	KEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	5.81e-04	15	34	2	M47971
Pathway	BIOCARTA_ERYTH_PATHWAY	TGFB1 TGFB2	5.81e-04	15	34	2	M9367
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	TGFB1 TGFB2 AKT1 AKT2	5.82e-04	161	34	4	M39770
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEM POTEG POTEB2 POTEH POTEB POTEC	2.50e-17	6	62	6	17171436
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEB3 POTEE POTEG POTED POTEH POTEB	1.75e-16	7	62	6	15276201
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEB3 POTED POTEB2 POTEH POTEB POTEC	6.99e-16	8	62	6	12475935
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	POTEB3 POTEE POTEM POTEF POTEG POTEI POTEB2 POTEH POTEB POTEC	3.37e-13	163	62	10	24316575
Pubmed	Identification and characterization of TSAP, a novel gene specifically expressed in testis during spermatogenesis.	POTEM POTEH POTEB POTEC	9.15e-12	4	62	4	17342726
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEE POTEM POTEF POTEG POTEI	4.52e-11	15	62	5	16824795
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	POTEE POTEM POTED POTEI	1.15e-09	9	62	4	16364570
Pubmed	Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7.	OSBPL3 OSBPL7 OSBPL6	5.39e-09	3	62	3	14593528
Pubmed	Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos.	TGFB1 TGFB2 AKT1 AKT2	9.04e-09	14	62	4	12773577
Pubmed	The OSBP-related protein family in humans.	OSBPL3 OSBPL7 OSBPL6	8.81e-07	11	62	3	11483621
Pubmed	A family of 12 human genes containing oxysterol-binding domains.	OSBPL3 OSBPL7 OSBPL6	1.17e-06	12	62	3	11735225
Pubmed	Vimentin is a novel AKT1 target mediating motility and invasion.	TRHDE AKT1 AKT2	1.17e-06	12	62	3	20856200
Pubmed	An oxysterol-binding protein family identified in the mouse.	OSBPL3 OSBPL7 OSBPL6	1.17e-06	12	62	3	12215260
Pubmed	Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.	AKT1 AKT2	3.13e-06	2	62	2	27878243
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR1 TLR6	3.13e-06	2	62	2	22315281
Pubmed	BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.	AKT1 AKT2	3.13e-06	2	62	2	27699769
Pubmed	A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression.	TGFB1 TGFB2	3.13e-06	2	62	2	27782106
Pubmed	Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.	AKT1 AKT2	3.13e-06	2	62	2	31252679
Pubmed	Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.	AKT1 AKT2	3.13e-06	2	62	2	19622728
Pubmed	Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients.	AKT1 AKT2	3.13e-06	2	62	2	28271235
Pubmed	Role of Akt in cardiac growth and metabolism.	AKT1 AKT2	3.13e-06	2	62	2	17019809
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR1 TLR6	3.13e-06	2	62	2	26470427
Pubmed	Transforming growth factor-beta in the early mouse embryo: implications for the regulation of muscle formation and implantation.	TGFB1 TGFB2	3.13e-06	2	62	2	8358866
Pubmed	Knockout of Akt1/2 suppresses the metastasis of human prostate cancer cells CWR22rv1 in vitro and in vivo.	AKT1 AKT2	3.13e-06	2	62	2	33377281
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR1 TLR6	3.13e-06	2	62	2	21852947
Pubmed	Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin.	AKT1 AKT2	3.13e-06	2	62	2	9620559
Pubmed	Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts.	AKT1 AKT2	3.13e-06	2	62	2	11861503
Pubmed	Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.	AKT1 AKT2	3.13e-06	2	62	2	12808085
Pubmed	Endothelium-dependent epithelial-mesenchymal transition of tumor cells: exclusive roles of transforming growth factor β1 and β2.	TGFB1 TGFB2	3.13e-06	2	62	2	23668958
Pubmed	Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-β-dependent pathways in genotype-specific oral cancer.	TGFB1 TGFB2	3.13e-06	2	62	2	27803052
Pubmed	TGF-β1 stimulates movement of renal proximal tubular epithelial cells in a three-dimensional cell culture via an autocrine TGF-β2 production.	TGFB1 TGFB2	3.13e-06	2	62	2	27880866
Pubmed	Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.	AKT1 AKT2	3.13e-06	2	62	2	15010337
Pubmed	Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.	AKT1 AKT2	3.13e-06	2	62	2	36229454
Pubmed	Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.	AKT1 INPP5J	3.13e-06	2	62	2	33537929
Pubmed	TGF beta1 and TGF beta2 and their role in posthemorrhagic hydrocephalus following SAH and IVH.	TGFB1 TGFB2	3.13e-06	2	62	2	23690072
Pubmed	Akt2 regulates cardiac metabolism and cardiomyocyte survival.	AKT1 AKT2	3.13e-06	2	62	2	16950770
Pubmed	Akt isoforms differentially regulate neutrophil functions.	AKT1 AKT2	3.13e-06	2	62	2	20332370
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEE POTEF	3.13e-06	2	62	2	19669888
Pubmed	Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.	AKT1 AKT2	3.13e-06	2	62	2	3037531
Pubmed	High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis.	AKT1 AKT2	3.13e-06	2	62	2	32078465
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR1 TLR6	3.13e-06	2	62	2	11123271
Pubmed	Defining Akt actions in muscle differentiation.	AKT1 AKT2	3.13e-06	2	62	2	23076793
Pubmed	Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.	AKT1 AKT2	3.13e-06	2	62	2	19110052
Pubmed	Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.	AKT1 AKT2	3.13e-06	2	62	2	23919516
Pubmed	Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors.	AKT1 AKT2	3.13e-06	2	62	2	17804734
Pubmed	Lack of AKT in adipocytes causes severe lipodystrophy.	AKT1 AKT2	3.13e-06	2	62	2	27408773
Pubmed	Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.	AKT1 AKT2	3.13e-06	2	62	2	17141631
Pubmed	PI3K/AKT Signaling in Breast Cancer Molecular Subtyping and Lymph Node Involvement.	AKT1 AKT2	3.13e-06	2	62	2	31781306
Pubmed	Effect of topical retinoic acids on the levels of collagen mRNA during the repair of UVB-induced dermal damage in the hairless mouse and the possible role of TGF-beta as a mediator.	TGFB1 HR	3.13e-06	2	62	2	1545145
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR1 TLR6	3.13e-06	2	62	2	29175392
Pubmed	Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma.	TGFB1 TGFB2	3.13e-06	2	62	2	20300191
Pubmed	Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.	AKT1 AKT2	3.13e-06	2	62	2	30692211
Pubmed	Distinct actions of akt1 on skeletal architecture and function.	AKT1 AKT2	3.13e-06	2	62	2	24663486
Pubmed	Elevated TGF-β1 and -β2 expression accelerates the epithelial to mesenchymal transition in triple-negative breast cancer cells.	TGFB1 TGFB2	3.13e-06	2	62	2	26088755
Pubmed	Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.	AKT1 AKT2	3.13e-06	2	62	2	19491266
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR1 TLR6	3.13e-06	2	62	2	28474755
Pubmed	Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.	AKT1 AKT2	3.13e-06	2	62	2	17609365
Pubmed	Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.	AKT1 AKT2	3.13e-06	2	62	2	17825284
Pubmed	TGF-β Pathways Stratify Colorectal Cancer into Two Subtypes with Distinct Cartilage Oligomeric Matrix Protein (COMP) Expression-Related Characteristics.	TGFB1 COMP	3.13e-06	2	62	2	36551305
Pubmed	Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination.	AKT1 AKT2	3.13e-06	2	62	2	31847370
Pubmed	Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.	AKT1 AKT2	3.13e-06	2	62	2	26654940
Pubmed	Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.	AKT1 AKT2	3.13e-06	2	62	2	16923802
Pubmed	Cardiomyopathy in young adults with classic mitral valve prolapse.	TGFB1 TGFB2	3.13e-06	2	62	2	23880103
Pubmed	Role of AMPK and Akt in triple negative breast cancer lung colonization.	AKT1 AKT2	3.13e-06	2	62	2	33839456
Pubmed	Loss of Akt1 evokes epithelial-mesenchymal transition by autocrine regulation of transforming growth factor-β1.	TGFB1 AKT1	3.13e-06	2	62	2	21925532
Pubmed	Akt1 and Akt2: differentiating the aktion.	AKT1 AKT2	3.13e-06	2	62	2	21432781
Pubmed	Molecular alterations in AKT and its protein activation in human lung carcinomas.	AKT1 AKT2	3.13e-06	2	62	2	22748472
Pubmed	Variations in transforming growth factor beta in human milk are not related to levels in plasma.	TGFB1 TGFB2	3.13e-06	2	62	2	11991670
Pubmed	Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.	AKT1 AKT2	3.13e-06	2	62	2	17045205
Pubmed	Strain-dependent effects of transforming growth factor-β1 and 2 during mouse secondary palate development.	TGFB1 TGFB2	3.13e-06	2	62	2	25450421
Pubmed	HIV-1 infection and HIV-1 Tat protein permit the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production.	TGFB1 TGFB2	3.13e-06	2	62	2	18457978
Pubmed	Primary and immortalized mouse epicardial cells undergo differentiation in response to TGFbeta.	TGFB1 TGFB2	3.13e-06	2	62	2	18213583
Pubmed	Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease.	AKT1 AKT2	3.13e-06	2	62	2	31671832
Pubmed	PKB signaling and atrogene expression in skeletal muscle of aged mice.	AKT1 AKT2	3.13e-06	2	62	2	21551011
Pubmed	Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.	AKT1 AKT2	3.13e-06	2	62	2	24769357
Pubmed	Mast cells are a source of transforming growth factor β in systemic sclerosis.	TGFB1 TGFB2	3.13e-06	2	62	2	21360509
Pubmed	Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells.	AKT1 AKT2	3.13e-06	2	62	2	23567263
Pubmed	TGF-β1 and TGF-β2 abundance in liver diseases of mice and men.	TGFB1 TGFB2	3.13e-06	2	62	2	26799667
Pubmed	Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.	AKT1 AKT2	3.13e-06	2	62	2	16365168
Pubmed	The effects of retinoid status on TGF beta expression during mouse embryogenesis.	TGFB1 TGFB2	3.13e-06	2	62	2	7485998
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR1 TLR6	3.13e-06	2	62	2	18036178
Pubmed	Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.	AKT1 AKT2	3.13e-06	2	62	2	15102693
Pubmed	AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes.	AKT1 AKT2	3.13e-06	2	62	2	25162660
Pubmed	The Akt1 isoform is an essential mediator of ischaemic preconditioning.	AKT1 AKT2	3.13e-06	2	62	2	22117619
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR1 TLR6	3.13e-06	2	62	2	24445834
Pubmed	Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation.	AKT1 AKT2	3.13e-06	2	62	2	19142853
Pubmed	Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.	AKT1 AKT2	3.13e-06	2	62	2	15545269
Pubmed	Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.	AKT1 AKT2	3.13e-06	2	62	2	22275470
Pubmed	Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets.	AKT1 AKT2	3.13e-06	2	62	2	26318486
Pubmed	Cholesterol regulates contractility and inotropic response to β2-adrenoceptor agonist in the mouse atria: Involvement of Gi-protein-Akt-NO-pathway.	AKT1 NOS2	3.13e-06	2	62	2	27170493
Pubmed	Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.	AKT1 AKT2	3.13e-06	2	62	2	25136137
Pubmed	Differential function of Akt1 and Akt2 in human adipocytes.	AKT1 AKT2	3.13e-06	2	62	2	22480544
Pubmed	Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.	AKT1 AKT2	3.13e-06	2	62	2	22647600
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR1 TLR6	3.13e-06	2	62	2	24984237
Pubmed	Akt isoform-specific inhibition of MDA-MB-231 cell proliferation.	AKT1 AKT2	3.13e-06	2	62	2	20688159
Pubmed	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.	AKT1 AKT2	3.13e-06	2	62	2	26971877
Pubmed	Significance of Akt activation and AKT gene increases in soft tissue tumors.	AKT1 AKT2	3.13e-06	2	62	2	24321521
Pubmed	Role of transforming growth factor-beta in breast milk for initiation of IgA production in newborn infants.	TGFB1 TGFB2	3.13e-06	2	62	2	15113633
Pubmed	iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation.	AKT1 NOS2	3.13e-06	2	62	2	36585107
Pubmed	Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma.	TGFB1 TGFB2	3.13e-06	2	62	2	17651146
Interaction	POTEC interactions	POTEB3 POTEF POTEG POTED POTEC	2.49e-10	13	60	5	int:POTEC
Interaction	POTEG interactions	POTEF POTEG POTEH POTEC	3.45e-08	12	60	4	int:POTEG
Interaction	POTEB3 interactions	POTEB3 POTEF POTED POTEB2 POTEC	5.98e-08	35	60	5	int:POTEB3
Interaction	POTED interactions	POTEB3 POTED POTEC	1.00e-07	4	60	3	int:POTED
Interaction	OSBPL7 interactions	OSBPL3 OSBPL7 OSBPL6	5.42e-06	12	60	3	int:OSBPL7
Interaction	POTEH interactions	POTEG POTEH	8.72e-06	2	60	2	int:POTEH
Interaction	TLR2 interactions	TGFB1 TLR1 AKT1 TLR6	1.73e-05	52	60	4	int:TLR2
Interaction	BTBD10 interactions	LAMA5 AKT1 AKT2	3.71e-05	22	60	3	int:BTBD10
Interaction	POTEB2 interactions	POTEB3 POTEB2	1.30e-04	6	60	2	int:POTEB2
Interaction	POTEA interactions	VPS9D1 POTEG	1.30e-04	6	60	2	int:POTEA
Interaction	MTCP1 interactions	AKT1 AKT2	1.30e-04	6	60	2	int:MTCP1
Interaction	C1orf54 interactions	TGFB1 LAMA5 ST6GALNAC4 PRSS23 B4GALT6	1.39e-04	167	60	5	int:C1orf54
Cytoband	2q21.1	POTEE POTEF POTEI	6.54e-05	58	61	3	2q21.1
Cytoband	3p22.2	TRANK1 DCLK3	4.70e-04	24	61	2	3p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q21	POTEE POTEF POTEI	1.09e-03	151	61	3	chr2q21
Cytoband	4p14	TLR1 TLR6	1.44e-03	42	61	2	4p14
Cytoband	Ensembl 112 genes in cytogenetic band chr15q11	POTEB3 POTEB2 POTEB	3.06e-03	217	61	3	chr15q11
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	TLR1 TLR6	3.63e-03	67	61	2	chr4p14
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEE POTEM POTEF POTEG POTED POTEI POTEB2 POTEH POTEB POTEC	4.08e-25	13	42	10	685
GeneFamily	Ankyrin repeat domain containing	POTEE TRANK1 POTEM POTEF POTEG POTED ANKRD30A POTEI POTEB2 POTEH POTEB POTEC	1.95e-13	242	42	12	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OSBPL3 CYTH1 OSBPL7 AKT1 AKT2 FGD5 ARHGAP27	4.33e-07	206	42	7	682
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL3 OSBPL7 OSBPL6	2.53e-06	12	42	3	670
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR6	2.34e-04	10	42	2	948
GeneFamily	Phosphoinositide phosphatases	SYNJ2 INPP5J	2.50e-03	32	42	2	1079
Coexpression	RAO_BOUND_BY_SALL4_ISOFORM_B	POTEB3 POTEE POTEM POTEF POTEG POTEI POTEB2 POTEH POTEB POTEC	6.58e-07	584	59	10	MM1080
Coexpression	DARWICHE_PAPILLOMA_PROGRESSION_RISK	POTEM POTEB2 POTEH POTEB POTEC	2.06e-06	92	59	5	MM503
Coexpression	DESCARTES_ORGANOGENESIS_EPENDYMAL_CELL	CCDC30 POTEM POTEG POTEB2 POTEH POTEB POTEC	3.28e-06	282	59	7	MM3642
Coexpression	HALLMARK_ALLOGRAFT_REJECTION	TGFB1 TGFB2 TLR1 AKT1 TLR6 NOS2	5.89e-06	200	59	6	M5950
Coexpression	KATSANOU_ELAVL1_TARGETS_UP	POTEM LAMA5 POTEH POTEB POTEC	6.58e-05	188	59	5	MM1071
Coexpression	YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN	POTEM OSBPL6 POTEB2 POTEH POTEB POTEC	6.82e-05	309	59	6	MM1244
Coexpression	GSE21670_TGFB_VS_TGFB_AND_IL6_TREATED_STAT3_KO_CD4_TCELL_DN	VPS9D1 ARL6IP1 OSBPL3 AKT2 RAD21	8.82e-05	200	59	5	M7447
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	TGFB2 SLC15A2 DOK7 SKIDA1 OSBPL7 LAMA5 PRSS23	3.44e-09	172	60	7	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-9\|TCGA-Breast / Sample_Type by Project: Shred V9	POTEE POTEM POTEF POTEI POTEH	1.43e-07	90	60	5	96e836c7a1df279ac812b7c3aa75e6b81b614244
ToppCell	TCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11\|TCGA-Brain / Sample_Type by Project: Shred V9	POTEE POTEF POTEG POTEI	1.60e-06	63	60	4	d7dc1356a60cb527fe668328d5375f352239d911
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NRDE2 SYNJ2 OSBPL3 POTEF FAM227B	6.38e-06	194	60	5	8f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
Drug	Dobutamine	TGFB1 TGFB2 AKT1 AKT2 NOS2	1.65e-06	78	58	5	ctd:D004280
Drug	Furaltadone hydrochloride [3759-92-0]; Up 200; 11uM; PC3; HT_HG-U133A	SLC15A2 SYNJ2 TLR1 SAYSD1 HCFC1 INPP5J	1.02e-05	195	58	6	4313_UP
Drug	FSL-1 lipoprotein, synthetic	TLR1 TLR6 NOS2	1.48e-05	19	58	3	ctd:C460864
Drug	dihydrolipoic acid	TGFB1 AKT1 NOS2	1.73e-05	20	58	3	ctd:C015144
Drug	4'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol	AKT1 NOS2	1.91e-05	3	58	2	ctd:C569748
Drug	sodium tungstate(VI)	TGFB1 TGFB2 AKT2	2.02e-05	21	58	3	ctd:C025399
Drug	Enalapril	TGFB1 TGFB2 SLC15A2 AKT1 NOS2	2.10e-05	131	58	5	ctd:D004656
Drug	Cysteine	TGFB1 TGFB2 AKT1 NOS2	2.43e-05	66	58	4	ctd:D003545
Drug	Pam(3)CSK(4) peptide	TLR1 TLR6 NOS2	3.47e-05	25	58	3	ctd:C508075
Drug	glycerylcysteine	TLR1 TLR6	3.81e-05	4	58	2	CID000152469
Drug	delphinidin 3-O-glucopyranoside	AKT1 NOS2	3.81e-05	4	58	2	ctd:C494120
Drug	1-cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl)-piperazine	AKT1 NOS2	3.81e-05	4	58	2	ctd:C505382
Drug	AC1O3MMZ	TGFB1 TGFB2	3.81e-05	4	58	2	CID006332294
Drug	Fungal Polysaccharides	TLR1 TLR6 NOS2 RAD21	3.82e-05	74	58	4	ctd:D062610
Drug	N-vinyl-2-pyrrolidinone	TGFB1 AKT1 AKT2	3.91e-05	26	58	3	ctd:C042670
Drug	SR 144528	TGFB1 AKT1 NOS2	4.39e-05	27	58	3	ctd:C110630
Drug	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	TLR1 AKT1 TLR6 NOS2	4.47e-05	77	58	4	ctd:C095512
Drug	AC1O0B8G	TGFB2 ARL6IP1 LAMA5 AKT1 PRSS23 NOS2	5.38e-05	262	58	6	CID000091605
Drug	25-hydroxycholesterol	TGFB1 OSBPL3 OSBPL7 OSBPL6 NOS2	5.46e-05	160	58	5	CID000065094
Drug	Butyric Acid	TGFB1 TLR1 AKT1 AKT2 TLR6	5.63e-05	161	58	5	ctd:D020148
Drug	PB28 compound	AKT1 NOS2	6.35e-05	5	58	2	ctd:C513937
Drug	Dr 27	TGFB1 TGFB2	6.35e-05	5	58	2	CID006449937
Drug	PtdIns(3,4)P	OSBPL3 CYTH1 AKT1 AKT2	7.21e-05	87	58	4	CID000643960
Drug	acetylbetulinic acid	TGFB1 TGFB2 AKT1 NOS2	7.54e-05	88	58	4	CID000289984
Drug	sodium pentaborate	TGFB1 LAMA5 NOS2	8.11e-05	33	58	3	ctd:C538809
Drug	manumycin	TGFB1 AKT1 NOS2	8.11e-05	33	58	3	ctd:C054474
Drug	aminoguanidine bicarbonate	TGFB1 NOS2	9.50e-05	6	58	2	CID000164944
Drug	1-hexacosanol	TGFB1 NOS2	9.50e-05	6	58	2	ctd:C051942
Drug	wuzi yanzong	AKT1 NOS2	9.50e-05	6	58	2	ctd:C528421
Drug	salvianolic acid B	TGFB1 AKT1 NOS2	9.69e-05	35	58	3	ctd:C076944
Drug	AC1L1GHE	TGFB1 TGFB2 AKT2 NOS2	1.06e-04	96	58	4	CID000003684
Drug	NSC23766	TLR1 AKT1 TLR6 NOS2	1.15e-04	98	58	4	CID000409805
Drug	2-anisidine	TLR1 AKT1 TLR6 NOS2	1.19e-04	99	58	4	ctd:C003898
Drug	AC1MQZ6I	TGFB1 TRHDE COMP AKT1 NOS2	1.23e-04	190	58	5	CID003509873
Drug	SC-58125	TGFB1 TGFB2 NOS2	1.24e-04	38	58	3	CID000115239
Drug	Carrageenan	TGFB1 AKT1 NOS2	1.24e-04	38	58	3	ctd:D002351
Drug	Dosulepin hydrochloride [897-15-4]; Down 200; 12uM; MCF7; HT_HG-U133A	TGFB2 SYNJ2 HCFC1 B4GALT6 HR	1.32e-04	193	58	5	5986_DN
Drug	isovalerylshikonin	AKT1 NOS2	1.33e-04	7	58	2	CID000335426
Drug	agmatine	TGFB1 COMP AKT1 NOS2	1.34e-04	102	58	4	CID000000199
Drug	Lithocholic acid [434-13-9]; Up 200; 10.6uM; PC3; HT_HG-U133A	TGFB2 OSBPL7 AKT2 B4GALT6 INPP5J	1.36e-04	194	58	5	3816_UP
Drug	CP-319743 [172078-87-4]; Down 200; 10uM; PC3; HT_HG-U133A	REXO5 SYNJ2 ST6GALNAC4 SAYSD1 HR	1.36e-04	194	58	5	7537_DN
Drug	Dipyrone [5907-38-0]; Up 200; 12uM; PC3; HT_HG-U133A	SLC15A2 TLR1 OSBPL7 HCFC1 CIC	1.36e-04	194	58	5	4310_UP
Drug	AC1Q5S0Y	TGFB1 SLC15A2 AKT1 NOS2	1.39e-04	103	58	4	CID000005650
Drug	Tranexamic acid [1197-18-8]; Down 200; 25.4uM; MCF7; HT_HG-U133A	CYTH1 HCFC1 CIC MCOLN3 HR	1.42e-04	196	58	5	2248_DN
Drug	Drofenine hydrochloride [548-66-3]; Up 200; 11.4uM; PC3; HT_HG-U133A	TGFB2 REXO5 SYNJ2 OSBPL3 CYTH1	1.42e-04	196	58	5	7129_UP
Drug	Midecamycin [35457-80-8]; Up 200; 5uM; MCF7; HT_HG-U133A	TGFB2 SYNJ2 CYTH1 AKT2 CIC	1.42e-04	196	58	5	5345_UP
Drug	Methoxamine hydrochloride [61-16-5]; Down 200; 16.2uM; MCF7; HT_HG-U133A	TGFB2 CYTH1 AKT2 CIC INPP5J	1.46e-04	197	58	5	2848_DN
Drug	Cephalexin monohydrate [23325-78-2]; Down 200; 11uM; MCF7; HT_HG-U133A	TGFB2 VPS9D1 SYNJ2 ST6GALNAC4 SAYSD1	1.46e-04	197	58	5	5250_DN
Drug	Raloxifene hydrochloride [82640-04-8]; Up 200; 7.8uM; PC3; HT_HG-U133A	VPS9D1 TRANK1 SLC15A2 CIC MCOLN3	1.46e-04	197	58	5	5759_UP
Drug	Canrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; MCF7; HT_HG-U133A	SYNJ2 SAYSD1 HCFC1 CIC HR	1.46e-04	197	58	5	2228_DN
Drug	Nifenazone [2139-47-1]; Down 200; 13uM; MCF7; HT_HG-U133A	TGFB1 AKT2 CIC B4GALT6 HR	1.49e-04	198	58	5	6016_DN
Drug	D-cycloserine [68-41-7]; Up 200; 39.2uM; HL60; HT_HG-U133A	VPS9D1 SYNJ2 LAMA5 NOS2 INPP5J	1.49e-04	198	58	5	6139_UP
Drug	Cyproterone acetate [427-51-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	VPS9D1 OSBPL7 SAYSD1 INPP5J HR	1.49e-04	198	58	5	4470_UP
Drug	Indoprofen [31842-01-0]; Down 200; 14.2uM; MCF7; HT_HG-U133A	TGFB2 VPS9D1 CYTH1 HCFC1 INPP5J	1.53e-04	199	58	5	3345_DN
Drug	Zinc Oxide	TGFB2 FAM20C TLR1 AKT1 TLR6 NOS2	1.53e-04	317	58	6	ctd:D015034
Drug	Rosuvastatin Calcium	TGFB1 AKT1 NOS2	1.56e-04	41	58	3	ctd:D000068718
Drug	esculetin	TGFB1 AKT1 NOS2	1.56e-04	41	58	3	ctd:C007628
Drug	E-guggulsterone	OSBPL7 OSBPL6 AKT1 NOS2	1.67e-04	108	58	4	CID006439929
Drug	tricarbonyldichlororuthenium (II) dimer	TGFB1 AKT1 NOS2	1.68e-04	42	58	3	ctd:C447082
Drug	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	AKT1 AKT2	1.77e-04	8	58	2	ctd:C532657
Drug	Sitagliptin Phosphate	TGFB1 NOS2	1.77e-04	8	58	2	ctd:D000068900
Drug	sym-trinitrobenzene	TGFB1 NOS2	1.77e-04	8	58	2	ctd:C029222
Drug	Glycosides	TGFB1 NOS2	1.77e-04	8	58	2	ctd:D006027
Drug	WJ1376-1	TGFB1 AKT1	1.77e-04	8	58	2	ctd:C000588914
Drug	WJ1398-1	TGFB1 AKT1	1.77e-04	8	58	2	ctd:C000588915
Drug	phlorofucofuroeckol A	AKT1 NOS2	1.77e-04	8	58	2	ctd:C064093
Drug	Primal	POTED ANKRD30A POTEC	1.80e-04	43	58	3	CID001549157
Drug	Chloroquine	TLR1 AKT1 TLR6 NOS2	1.85e-04	111	58	4	ctd:D002738
Drug	AC1L1K7T	TGFB1 TGFB2 OSBPL7 OSBPL6 AKT1 AKT2 PRSS23 NOS2	1.90e-04	632	58	8	CID000005376
Drug	Carmustine	TGFB1 SLC15A2 CYTH1 AKT1 AKT2 NOS2 HCFC1	2.21e-04	484	58	7	ctd:D002330
Drug	N-hexacosanol	TGFB1 NOS2	2.27e-04	9	58	2	CID000068171
Drug	Aminoimidazole Carboxamide	TGFB1 NOS2	2.27e-04	9	58	2	ctd:D000620
Drug	homoorientin	TGFB1 AKT1	2.27e-04	9	58	2	ctd:C057912
Drug	SecinH3	CYTH1 AKT1	2.27e-04	9	58	2	CID001029232
Drug	bifendate	TGFB1 NOS2	2.27e-04	9	58	2	ctd:C465548
Drug	As60A	TGFB1 NOS2	2.27e-04	9	58	2	CID000832684
Drug	linsidomine	TGFB1 AKT1 NOS2	2.35e-04	47	58	3	ctd:C002385
Drug	coenzyme Q10	TGFB1 AKT1 NOS2	2.50e-04	48	58	3	ctd:C024989
Drug	gadodiamide	TGFB1 AKT1 NOS2	2.50e-04	48	58	3	ctd:C064925
Drug	raloxifene	TGFB1 TGFB2 OSBPL7 OSBPL6 AKT1 NOS2	2.65e-04	351	58	6	CID000005035
Drug	Ossirene	TGFB1 TGFB2 AKT1	2.82e-04	50	58	3	CID000451379
Drug	8-oxo-GTP	AKT1 NOS2	2.83e-04	10	58	2	CID000167974
Drug	triciribine	AKT1 AKT2	2.83e-04	10	58	2	ctd:C023764
Drug	BY 308	TGFB1 TGFB2	2.83e-04	10	58	2	CID000128828
Drug	1,2-diacylglycerol	COMP CYTH1	2.83e-04	10	58	2	CID000066021
Drug	5-hydroxydecanoic acid	AKT1 NOS2	2.83e-04	10	58	2	ctd:C052853
Drug	AC1L1E7E	TGFB1 SLC15A2	2.83e-04	10	58	2	CID000002673
Drug	1 pt	TGFB1 TGFB2	2.83e-04	10	58	2	CID000447833
Drug	KMUP 1	AKT1 NOS2	2.83e-04	10	58	2	ctd:C439304
Drug	malvidin-3-glucoside	AKT1 NOS2	2.83e-04	10	58	2	ctd:C458419
Drug	propazine	AKT1 NOS2	2.83e-04	10	58	2	ctd:C100043
Drug	tin protoporphyrin IX	TGFB1 AKT1 NOS2	3.00e-04	51	58	3	ctd:C032628
Drug	15-epi-lipoxin A4	TGFB1 AKT1 NOS2 INPP5J	3.20e-04	128	58	4	CID000003934
Drug	Sildenafil Citrate	TGFB1 AKT1 NOS2	3.36e-04	53	58	3	ctd:D000068677
Drug	ursolic acid	TGFB1 AKT1 NOS2	3.36e-04	53	58	3	ctd:C005466
Drug	3-methylquercetin	TGFB1 AKT1 NOS2	3.36e-04	53	58	3	ctd:C047368
Drug	d 42	TGFB1 TGFB2	3.46e-04	11	58	2	CID005288018
Drug	MMEA	AKT1 AKT2	3.46e-04	11	58	2	CID000125823
Drug	di-n-butyltin	AKT1 NOS2	3.46e-04	11	58	2	ctd:C056189
Drug	Cilazapril	TGFB1 SLC15A2	3.46e-04	11	58	2	ctd:D017315
Disease	Ureteral obstruction	TGFB1 TGFB2 NOS2	7.98e-06	24	48	3	C0041956
Disease	Adenocarcinoma of large intestine	DCLK3 AKT1 AKT2 RAD21	1.83e-05	96	48	4	C1319315
Disease	paraplegia (biomarker_via_orthology)	AKT1 NOS2	2.58e-05	5	48	2	DOID:607 (biomarker_via_orthology)
Disease	Duodenal Ulcer	TGFB1 NOS2	3.87e-05	6	48	2	C0013295
Disease	Curling Ulcer	TGFB1 NOS2	3.87e-05	6	48	2	C0010474
Disease	aspergillosis (is_implicated_in)	TLR1 TLR6	7.21e-05	8	48	2	DOID:13564 (is_implicated_in)
Disease	Hepatic Insufficiency	TGFB1 NOS2	9.26e-05	9	48	2	C1306571
Disease	asthma (is_implicated_in)	TGFB1 TLR1 TLR6 NOS2	1.25e-04	157	48	4	DOID:2841 (is_implicated_in)
Disease	colorectal cancer (is_marker_for)	TGFB1 TGFB2 AKT1 AKT2	1.25e-04	157	48	4	DOID:9256 (is_marker_for)
Disease	Aortic Valve Insufficiency	TGFB1 TGFB2	1.41e-04	11	48	2	C0003504
Disease	cholangiocarcinoma (is_marker_for)	TGFB1 OSBPL7 NOS2	1.57e-04	64	48	3	DOID:4947 (is_marker_for)
Disease	colon carcinoma (is_marker_for)	TGFB1 TGFB2	2.00e-04	13	48	2	DOID:1520 (is_marker_for)
Disease	age of onset of asthma	TLR1 FAM227B TLR6	2.93e-04	79	48	3	OBA_2001001
Disease	Malignant neoplasm of breast	OTOF SYNJ2 ANKRD30A AKT1 AKT2 FGD5 NOS2 CIC	3.10e-04	1074	48	8	C0006142
Disease	Pulmonary Emphysema	TGFB1 TGFB2	3.47e-04	17	48	2	C0034067
Disease	diabetic neuropathy (biomarker_via_orthology)	TGFB1 TGFB2	3.47e-04	17	48	2	DOID:9743 (biomarker_via_orthology)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR6	3.47e-04	17	48	2	DOID:8677 (biomarker_via_orthology)
Disease	pulse pressure measurement	TGFB1 TRANK1 CCDC30 NBEAL1 CYTH1 OSBPL7 LAMA5 FGD5 HCFC1	3.58e-04	1392	48	9	EFO_0005763
Disease	osteochondrodysplasia (is_implicated_in)	TGFB1 COMP	4.35e-04	19	48	2	DOID:2256 (is_implicated_in)
Disease	prostate adenocarcinoma (is_implicated_in)	AKT1 AKT2	4.83e-04	20	48	2	DOID:2526 (is_implicated_in)
Disease	impotence (biomarker_via_orthology)	TGFB1 NOS2	5.86e-04	22	48	2	DOID:1875 (biomarker_via_orthology)
Disease	pancreatic cancer (is_marker_for)	TGFB1 AKT1 NOS2	6.02e-04	101	48	3	DOID:1793 (is_marker_for)
Disease	obesity (is_marker_for)	TGFB1 AKT2 NOS2	6.02e-04	101	48	3	DOID:9970 (is_marker_for)
Disease	coronary artery disease	TGFB1 CRACD TENT4A CCDC30 NBEAL1 DOK7 FGD5 SAYSD1	6.27e-04	1194	48	8	EFO_0001645
Disease	malignant astrocytoma (is_marker_for)	AKT1 AKT2	6.41e-04	23	48	2	DOID:3069 (is_marker_for)
Disease	Septicemia	TGFB1 NOS2	6.99e-04	24	48	2	C0036690
Disease	Sepsis	TGFB1 NOS2	6.99e-04	24	48	2	C0243026
Disease	Severe Sepsis	TGFB1 NOS2	6.99e-04	24	48	2	C1719672
Disease	Pyemia	TGFB1 NOS2	6.99e-04	24	48	2	C0034189
Disease	hepatocellular carcinoma (biomarker_via_orthology)	AKT1 AKT2 NOS2	7.32e-04	108	48	3	DOID:684 (biomarker_via_orthology)
Disease	interstitial lung disease (is_marker_for)	TGFB1 NOS2	7.59e-04	25	48	2	DOID:3082 (is_marker_for)
Disease	Depressive Symptoms	TGFB1 SYNJ2	8.21e-04	26	48	2	C0086132
Disease	Nephrotic Syndrome	TGFB1 LAMA5	8.86e-04	27	48	2	C0027726
Disease	pancreatic ductal adenocarcinoma (is_marker_for)	TGFB1 TGFB2	8.86e-04	27	48	2	DOID:3498 (is_marker_for)
Disease	Lung Neoplasms	TGFB1 AKT1 NOS2 RAD21	9.07e-04	265	48	4	C0024121
Disease	Malignant neoplasm of lung	TGFB1 AKT1 NOS2 RAD21	9.20e-04	266	48	4	C0242379
Disease	Hyalinosis, Segmental Glomerular	TGFB1 NOS2	9.53e-04	28	48	2	C0086432
Disease	Hyperplasia	TGFB1 AKT1	9.53e-04	28	48	2	C0020507
Disease	tuberculosis (is_implicated_in)	TLR1 TLR6	9.53e-04	28	48	2	DOID:399 (is_implicated_in)
Disease	asthma, Eczema, allergic rhinitis	SLC15A2 TLR1 ARHGAP27	1.02e-03	121	48	3	EFO_0005854, HP_0000964, MONDO_0004979
Disease	Neoplasm of uncertain or unknown behavior of ovary	AKT1 AKT2	1.02e-03	29	48	2	C0496920
Disease	Ovarian Carcinoma	AKT1 AKT2	1.09e-03	30	48	2	C0029925
Disease	pulmonary hypertension (is_implicated_in)	TGFB1 NOS2	1.09e-03	30	48	2	DOID:6432 (is_implicated_in)
Disease	proteinuria (implicated_via_orthology)	TGFB1 HR	1.09e-03	30	48	2	DOID:576 (implicated_via_orthology)
Disease	Inflammation	TGFB1 AKT1 NOS2	1.17e-03	127	48	3	C0021368
Disease	Cholestasis, Extrahepatic	TGFB1 NOS2	1.25e-03	32	48	2	C0005398
Disease	Chronic Obstructive Airway Disease	TGFB1 NOS2	1.32e-03	33	48	2	C0024117
Disease	Chronic Airflow Obstruction	TGFB1 NOS2	1.32e-03	33	48	2	C1527303
Disease	lung disease (biomarker_via_orthology)	TGFB1 NOS2	1.49e-03	35	48	2	DOID:850 (biomarker_via_orthology)
Disease	endometrial cancer (is_implicated_in)	AKT2 RAD21	1.58e-03	36	48	2	DOID:1380 (is_implicated_in)
Disease	Focal glomerulosclerosis	TGFB1 NOS2	1.58e-03	36	48	2	C0017668
Disease	Mammary Carcinoma, Human	SYNJ2 AKT1 AKT2 FGD5 NOS2	1.59e-03	525	48	5	C4704874
Disease	Mammary Neoplasms, Human	SYNJ2 AKT1 AKT2 FGD5 NOS2	1.59e-03	525	48	5	C1257931
Disease	Eczema	SLC15A2 TLR1 OSBPL7 ARHGAP27	1.62e-03	310	48	4	HP_0000964
Disease	Mammary Neoplasms	SYNJ2 AKT1 AKT2 FGD5 NOS2	1.62e-03	527	48	5	C1458155

Protein segments in the cluster

Peptide	Gene	Start	Entry
HGRDLAWKFFRDKWK	TRHDE	931	Q9UKU6
WLHKRGEYIKTWRPR	AKT1	11	P31749
WLHKRGEYIKTWRPR	AKT2	11	P31751
SGLKPQKGFWIHWKL	FAM227B	291	Q96M60
LLWKDPRNVGWKDKK	COMP	666	P49747
FTWAAKGRPRKIAWE	ANKRD30A	406	Q9BXX3
GWWKRLFTLKEEKPK	ARL6IP1	121	Q15041
RGPWAKRKQNPIHWK	NBEAL1	1786	Q6ZS30
RGPLAKIWLAAHWEK	RAD21L1	11	Q9H4I0
RGPLAKIWLAAHWDK	RAD21	11	O60216
LHRAAWWGKVPRKDL	POTEB2	106	H3BUK9
WKTHVWQDEKRRPKR	NOS2	496	P35228
SRWEWKRLKAKTPKN	HCFC1	116	P51610
DKLHRAAWWGKVPRK	POTEF	141	A5A3E0
EKFWARGRKPWKLAI	MCOLN3	51	Q8TDD5
DDRARTQKKWGRGKW	DCLK3	86	Q9C098
RKVNWLGSKEGLRWK	HR	86	O43593
SRCKRGKRHWKKLWF	FGD5	1371	Q6ZNL6
HWRPWRPDKTKKQTE	NRDE2	591	Q9H7Z3
WLLKLGGGRVKTWKR	CYTH1	266	Q15438
RPGRWHKVSVRWEKN	LAMA5	3421	O15230
KHVKGAAKRLLGWEW	OR2J2	296	O76002
GFMLKKRKWPLKGWH	OSBPL6	91	Q9BZF3
KRKWPLKGWHKRFFV	OSBPL6	96	Q9BZF3
RWIKEKWGSKAHPSP	TENT4A	526	Q5XG87
IAGWKHEKSRRALKW	KIF19	461	Q2TAC6
DKLHRAAWWGKVPRK	POTEB3	141	A0JP26
DKLHRAAWWGKVPRK	POTEE	141	Q6S8J3
HWRPKDCKPRWKVAV	B4GALT6	146	Q9UBX8
EWKQGKIRKEIHWIP	LINC01599	166	Q8WXQ3
PWRRSYHKRKKAEWE	FAM20C	406	Q8IXL6
EPAWLALAKRKAKAW	CRACD	1211	Q6ZU35
NLKEFPVPKWWHRGK	CCDC30	631	Q5VVM6
GKKWKSRWLVLRKPS	DOK7	16	Q18PE1
VSWGKLKRRVKGWAP	CCDC8	201	Q9H0W5
KRQHWLDWAAEKYPK	SLC15A2	276	Q16348
FKQKRVKGWWPLLAR	OTOF	1881	Q9HC10
GFLLKKRKWPLKGWH	OSBPL3	56	Q9H4L5
EGHLLKKRKWPLKGW	OSBPL7	51	Q9BZF2
DKLHRAAWWGKVPRK	POTEC	141	B2RU33
DKLHRAAWWGKVPRK	POTED	141	Q86YR6
TDRVLWWRKKHPFDK	SYNJ2	801	O15056
WWRKKHPFDKTAGEL	SYNJ2	806	O15056
LHRAAWWGKVPRKDL	POTEB	106	A0A0A6YYL3
WIRVKRTHVPKGWIK	PRSS23	221	O95084
KGKRLRKKHWSASWT	ARHGAP27	511	Q6ZUM4
SPRPGFWKDKHQLWR	SKIDA1	126	Q1XH10
DKLHRAAWWGKVARK	POTEI	141	P0CG38
LEWPKEKSKRGLFWA	TLR1	756	Q15399
FKAHPDWKWCNKDRK	CIC	261	Q96RK0
KKNSPHEGKLIWWKD	ERVK-25	801	P63136
AKKRKPAWTDRILWK	INPP5J	671	Q15735
FKRDLGWKWIHEPKG	TGFB2	326	P61812
WAKKRPIVFAHPSWR	ST6GALNAC4	286	Q9H4F1
KLDHPKIAAWRWSRK	REXO5	711	Q96IC2
DFRKDLGWKWIHEPK	TGFB1	301	P01137
LKAAPGWLKRFLVWK	SAYSD1	41	Q9NPB0
LQWPKEKSKRGLFWA	TLR6	761	Q9Y2C9
KKNSPHEGKLIWWKD	ERVK-19	806	Q9WJR5
WPKHWKAKLKRNPGD	VPS9D1	251	Q9Y2B5
RWLMDHKPEWKGRIN	TRANK1	221	O15050
DKLHRAAWWGKVPRK	POTEG	141	Q6S5H5
DLDKLHRAAWWGKVP	POTEH	176	Q6S545
HRAAWWGKVPRKDLI	POTEH	181	Q6S545
DKLHRAAWWGKVPRK	POTEM	141	A6NI47