Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	neuron projection morphogenesis	SHANK1 SZT2 ETV1 LMTK2 TSC2 SRCIN1 MECP2 LZTS1 AUTS2 COBL DLG4 FLRT2 RERE AGRN MAPK8IP2 STK25	3.29e-06	802	106	16	GO:0048812
GeneOntologyBiologicalProcess	neuron development	SHANK1 ONECUT2 SLC4A7 SZT2 ETV1 LMTK2 TSC2 SRCIN1 TRIP11 MECP2 MICALL1 LZTS1 AUTS2 COBL DLG4 TRPM1 FLRT2 RERE AGRN MAPK8IP2 CREB3L2 STK25	4.25e-06	1463	106	22	GO:0048666
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	SHANK1 SZT2 ETV1 LMTK2 TSC2 SRCIN1 MECP2 LZTS1 AUTS2 COBL DLG4 FLRT2 RERE AGRN MAPK8IP2 STK25	4.30e-06	819	106	16	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	SHANK1 SZT2 ETV1 LMTK2 TSC2 SRCIN1 MECP2 LZTS1 AUTS2 COBL DLG4 FLRT2 RERE AGRN MAPK8IP2 STK25	4.79e-06	826	106	16	GO:0048858
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	SHANK1 SZT2 ETV1 LMTK2 TSC2 SRCIN1 LZTS1 AUTS2 COBL DLG4 FLRT2 RERE AGRN MAPK8IP2 STK25	6.48e-06	748	106	15	GO:0048667
GeneOntologyBiologicalProcess	cell morphogenesis	SHANK1 SZT2 ETV1 LMTK2 TSC2 SRCIN1 IDUA MECP2 JMJD1C LZTS1 AUTS2 COBL DLG4 FLRT2 RERE AGRN MAPK8IP2 GP1BA STK25	9.72e-06	1194	106	19	GO:0000902
GeneOntologyBiologicalProcess	behavior	SHANK1 HTR1A SLC4A7 CWH43 ETV1 ETV5 TSC2 IDUA MECP2 CNTNAP4 NAV2 AUTS2 DLG4 AGRN MAPK8IP2 BAHCC1	1.24e-05	891	106	16	GO:0007610
GeneOntologyBiologicalProcess	neuron projection development	SHANK1 SZT2 ETV1 LMTK2 TSC2 SRCIN1 TRIP11 MECP2 MICALL1 LZTS1 AUTS2 COBL DLG4 FLRT2 RERE AGRN MAPK8IP2 CREB3L2 STK25	2.71e-05	1285	106	19	GO:0031175
GeneOntologyBiologicalProcess	social behavior	SHANK1 TSC2 MECP2 DLG4 MAPK8IP2	3.96e-05	74	106	5	GO:0035176
GeneOntologyBiologicalProcess	biological process involved in intraspecies interaction between organisms	SHANK1 TSC2 MECP2 DLG4 MAPK8IP2	4.51e-05	76	106	5	GO:0051703
GeneOntologyBiologicalProcess	chromatin organization	FAM47A BAZ1B FAM47C RELA KDM6B KMT2E MECP2 JMJD1C WAC L3MBTL1 SCMH1 RAD54B RERE TCF7L1 BAHCC1	5.32e-05	896	106	15	GO:0006325
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	RALGAPA1 ARHGEF12 ARHGAP17 TSC2 DENND1A DENND4C AUTS2 AGRN ARHGAP21	5.56e-05	333	106	9	GO:0051056
GeneOntologyBiologicalProcess	dendrite development	SHANK1 TSC2 SRCIN1 MECP2 LZTS1 COBL DLG4 RERE MAPK8IP2	5.82e-05	335	106	9	GO:0016358
GeneOntologyBiologicalProcess	locomotory behavior	SLC4A7 CWH43 ETV5 IDUA MECP2 NAV2 DLG4 BAHCC1	1.10e-04	284	106	8	GO:0007626
GeneOntologyBiologicalProcess	regulation of synapse organization	ETV5 TSC2 SRCIN1 MECP2 LZTS1 CNTNAP4 DLG4 FLRT2 AGRN	1.74e-04	387	106	9	GO:0050807
GeneOntologyBiologicalProcess	protein-DNA complex organization	FAM47A BAZ1B FAM47C RELA KDM6B KMT2E MECP2 JMJD1C WAC L3MBTL1 SCMH1 RAD54B RERE TCF7L1 BAHCC1	1.78e-04	999	106	15	GO:0071824
GeneOntologyBiologicalProcess	postsynaptic membrane organization	HTR1A ETV5 DLG4 AGRN	1.97e-04	56	106	4	GO:0001941
GeneOntologyBiologicalProcess	regulation of synapse structure or activity	ETV5 TSC2 SRCIN1 MECP2 LZTS1 CNTNAP4 DLG4 FLRT2 AGRN	2.02e-04	395	106	9	GO:0050803
GeneOntologyBiologicalProcess	synapse organization	SHANK1 HTR1A ETV5 TSC2 SRCIN1 MECP2 LZTS1 CNTNAP4 DLG4 FLRT2 BSN AGRN	2.08e-04	685	106	12	GO:0050808
GeneOntologyBiologicalProcess	postsynapse organization	SHANK1 HTR1A ETV5 TSC2 SRCIN1 LZTS1 DLG4 AGRN	2.14e-04	313	106	8	GO:0099173
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ONECUT2 FOXN1 ZNF142 WNT1 ETV1 BAZ1B ETV5 TSC2 RELA ACVR1B KDM6B ONECUT1 MECP2 HOXB4 AUTS2 AGRN TCF7L1 CREB3L2	2.43e-04	1390	106	18	GO:0045944
GeneOntologyBiologicalProcess	vocalization behavior	SHANK1 AUTS2 DLG4	2.47e-04	24	106	3	GO:0071625
GeneOntologyBiologicalProcess	regulation of Rab protein signal transduction	DENND1A DENND4C	3.87e-04	6	106	2	GO:0032483
GeneOntologyBiologicalProcess	regulation of grooming behavior	CNTNAP4 DLG4	3.87e-04	6	106	2	GO:2000821
GeneOntologyBiologicalProcess	chromatin remodeling	FAM47A BAZ1B FAM47C KDM6B KMT2E MECP2 JMJD1C WAC L3MBTL1 SCMH1 RAD54B RERE	4.24e-04	741	106	12	GO:0006338
GeneOntologyBiologicalProcess	regulation of protein tyrosine kinase activity	SRCIN1 CBLB DLG4 AGRN	4.41e-04	69	106	4	GO:0061097
GeneOntologyBiologicalProcess	cell junction organization	SHANK1 HTR1A ETV5 TSC2 SRCIN1 MECP2 LZTS1 CNTNAP4 TJP2 DLG4 FLRT2 PEAK1 BSN AGRN	4.61e-04	974	106	14	GO:0034330
GeneOntologyBiologicalProcess	dendrite morphogenesis	SHANK1 SRCIN1 LZTS1 DLG4 RERE MAPK8IP2	5.58e-04	198	106	6	GO:0048813
HumanPheno	Abnormality of mouth size	RALGAPA1 AFF3 BAZ1B MED13L KDM6B IDUA MECP2 JMJD1C WAC AUTS2 LTBP3 RERE SPEN	1.17e-05	425	40	13	HP:0011337
HumanPheno	Macrostomia	RALGAPA1 AFF3 BAZ1B MED13L KDM6B IDUA WAC AUTS2 SPEN	3.76e-05	220	40	9	HP:0000181
HumanPheno	Wide mouth	RALGAPA1 AFF3 BAZ1B MED13L KDM6B IDUA WAC AUTS2 SPEN	3.76e-05	220	40	9	HP:0000154
MousePheno	malocclusion	BAZ1B MECP2 MAST4 LTBP3 PEAK1	1.36e-05	47	92	5	MP:0000120
MousePheno	misaligned teeth	BAZ1B MECP2 MAST4 LTBP3 PEAK1	2.25e-05	52	92	5	MP:0030540
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	7.49e-07	4	108	3	IPR029423
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	7.49e-07	4	108	3	PF14914
Domain	LRRC37_N	LRRC37A3 LRRC37A2 LRRC37A	7.49e-07	4	108	3	IPR032754
Domain	LRRC37	LRRC37A3 LRRC37A2 LRRC37A	7.49e-07	4	108	3	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2 LRRC37A	7.49e-07	4	108	3	IPR015753
Domain	ETS_PEA3_N	ETV1 ETV5	9.90e-05	3	108	2	IPR006715
Domain	ETS_PEA3_N	ETV1 ETV5	9.90e-05	3	108	2	PF04621
Domain	PDZ	SHANK1 ARHGEF12 MAST4 TJP2 DLG4 ARHGAP21	1.69e-04	141	108	6	PF00595
Domain	FAM47	FAM47A FAM47C	1.97e-04	4	108	2	PF14642
Domain	FAM47	FAM47A FAM47C	1.97e-04	4	108	2	IPR032743
Domain	PDZ	SHANK1 ARHGEF12 MAST4 TJP2 DLG4 ARHGAP21	2.20e-04	148	108	6	SM00228
Domain	-	SHANK1 ARHGEF12 MAST4 TJP2 DLG4 ARHGAP21	2.37e-04	150	108	6	2.30.42.10
Domain	PDZ	SHANK1 ARHGEF12 MAST4 TJP2 DLG4 ARHGAP21	2.46e-04	151	108	6	PS50106
Domain	PDZ	SHANK1 ARHGEF12 MAST4 TJP2 DLG4 ARHGAP21	2.54e-04	152	108	6	IPR001478
Domain	LRR_TYP	LRRC37A3 LRRC37A2 LRRC37A CEP72 FLRT2 GP1BA	5.73e-04	177	108	6	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A3 LRRC37A2 LRRC37A CEP72 FLRT2 GP1BA	5.73e-04	177	108	6	IPR003591
Domain	CUT	ONECUT2 ONECUT1	6.83e-04	7	108	2	PS51042
Domain	CUT	ONECUT2 ONECUT1	6.83e-04	7	108	2	PF02376
Domain	CUT_dom	ONECUT2 ONECUT1	6.83e-04	7	108	2	IPR003350
Domain	CUT	ONECUT2 ONECUT1	6.83e-04	7	108	2	SM01109
Domain	MBT	L3MBTL1 SCMH1	1.16e-03	9	108	2	SM00561
Domain	MBT	L3MBTL1 SCMH1	1.16e-03	9	108	2	PS51079
Domain	MBT	L3MBTL1 SCMH1	1.45e-03	10	108	2	PF02820
Domain	Mbt	L3MBTL1 SCMH1	1.45e-03	10	108	2	IPR004092
Domain	Rap_GAP	RALGAPA1 TSC2	1.45e-03	10	108	2	PF02145
Domain	Znf_FYVE_PHD	BAZ1B KMT2E PIKFYVE TRIM66 BSN	1.64e-03	147	108	5	IPR011011
Domain	Rap_GAP_dom	RALGAPA1 TSC2	1.76e-03	11	108	2	IPR000331
Domain	BAH	RERE BAHCC1	1.76e-03	11	108	2	PS51038
Domain	BAH_dom	RERE BAHCC1	1.76e-03	11	108	2	IPR001025
Domain	BAH	RERE BAHCC1	1.76e-03	11	108	2	SM00439
Domain	RAPGAP	RALGAPA1 TSC2	1.76e-03	11	108	2	PS50085
Domain	BAH	RERE BAHCC1	1.76e-03	11	108	2	PF01426
Domain	Galactose-bd-like	CEP104 DCBLD1 UBOX5 CNTNAP4	2.16e-03	94	108	4	IPR008979
Domain	LRR_8	LRRC37A3 LRRC37A2 LRRC37A FLRT2 GP1BA	3.17e-03	171	108	5	PF13855
Domain	DENN	DENND1A DENND4C	3.77e-03	16	108	2	SM00799
Domain	DENN	DENND1A DENND4C	3.77e-03	16	108	2	PF02141
Domain	dDENN	DENND1A DENND4C	3.77e-03	16	108	2	PF03455
Domain	UDENN	DENND1A DENND4C	3.77e-03	16	108	2	PS50946
Domain	DDENN	DENND1A DENND4C	3.77e-03	16	108	2	PS50947
Domain	dDENN	DENND1A DENND4C	3.77e-03	16	108	2	SM00801
Domain	dDENN_dom	DENND1A DENND4C	3.77e-03	16	108	2	IPR005112
Domain	uDENN_dom	DENND1A DENND4C	3.77e-03	16	108	2	IPR005113
Domain	DENN	DENND1A DENND4C	3.77e-03	16	108	2	PS50211
Domain	DENN_dom	DENND1A DENND4C	3.77e-03	16	108	2	IPR001194
Domain	Leu-rich_rpt	LRRC37A3 LRRC37A2 LRRC37A CEP72 FLRT2 GP1BA	4.92e-03	271	108	6	IPR001611
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP104 RALGAPA1 SZT2 LMTK2 KIAA1549 SRCIN1 KDM6B MICALL1 MAST4 NAV2 AUTS2 CACNA1G FAM149B1 BSN	1.45e-09	529	110	14	14621295
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SZT2 POLRMT LMTK2 ARHGAP17 TSC2 MED13L KDM6B IDUA DENND1A MICALL1 PIKFYVE HOXB4 NAV2 COBL LTBP3 SPEN AGRN ARHGAP21 BAHCC1	1.86e-09	1105	110	19	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RALGAPA1 SLC4A7 LMTK2 ARHGAP17 TSC2 TRIP11 DENND1A DENND4C MICALL1 MAST4 NAV2 TJP2 COBL SSH2 PEAK1 MAP3K21 ARHGAP21	1.89e-09	861	110	17	36931259
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2 LRRC37A	1.23e-07	4	110	3	22419166
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	JMJD1C CCDC85A WAC PIKFYVE TRIM66 SACS CEP72 CNTNAP4 FLRT2 SSH2 PEAK1	5.02e-07	493	110	11	15368895
Pubmed	Sex Hormones Regulate SHANK Expression.	SHANK1 MECP2 DLG4	1.70e-06	8	110	3	30319350
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SHANK1 DBF4B TSC2 TACC2 L3MBTL1 CEP72 SCMH1 COBL DLG4 LTBP3 AGRN	1.73e-06	560	110	11	21653829
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	SLC4A7 ARHGEF12 SRCIN1 TRIP11 DENND4C EHD4 MICALL1 NAV2 TJP2 PEAK1 ARHGAP21	1.89e-06	565	110	11	25468996
Pubmed	Superresolution imaging of chemical synapses in the brain.	SHANK1 DLG4 BSN	2.55e-06	9	110	3	21144999
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SHANK1 RALGAPA1 ARHGEF12 KIAA1549 SRCIN1 TRIP11 MECP2 SACS LZTS1 TJP2 OTUD4 DLG4 SSH2 PEAK1 BSN ARHGAP21 MAPK8IP2	2.61e-06	1431	110	17	37142655
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2 LRRC37A	3.63e-06	10	110	3	23064749
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TOR1AIP2 ZNF536 ZNF142 LRRC37A3 TRIP11 CCDC85A CEP72 LZTS1 OTUD4 BSN SPEN	6.00e-06	638	110	11	31182584
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF536 ARHGEF12 MED13L OTUD4 ACIN1 COBL RERE SPEN ARHGAP21	6.18e-06	407	110	9	12693553
Pubmed	Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.	SHANK1 DLG4	9.91e-06	2	110	2	18272690
Pubmed	Dose-dependent regulation of horizontal cell fate by Onecut family of transcription factors.	ONECUT2 ONECUT1	9.91e-06	2	110	2	32790713
Pubmed	NF-κB downregulates Cbl-b through binding and suppressing Cbl-b promoter in T cell activation.	RELA CBLB	9.91e-06	2	110	2	25762784
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	BAZ1B TSC2 JMJD1C WAC EHD4 ACIN1 SPEN RBM17	1.35e-05	341	110	8	32971831
Pubmed	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.	ETV5 CCDC85A TRIM66 RBM6	1.40e-05	46	110	4	21102462
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF536 ARHGEF12 KDM6B TRIM66 MAST4	2.07e-05	104	110	5	9205841
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	RBM33 MED13L JMJD1C WAC FOXP4 RERE RBM17	2.41e-05	268	110	7	33640491
Pubmed	Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.	ONECUT2 ETV1 ONECUT1	2.43e-05	18	110	3	31969659
Pubmed	A human MAP kinase interactome.	SHANK1 ZNF142 RBM33 ARHGAP17 RELA CBLB NAV2 COBL MAP3K21	2.52e-05	486	110	9	20936779
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SHANK1 ONECUT2 ZNF142 SLC4A7 RBM33 MXRA8 BAZ1B KMT2E ONECUT1 MECP2 JMJD1C WAC AUTS2 RERE	2.72e-05	1203	110	14	29180619
Pubmed	A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.	EHD4 MICALL1	2.97e-05	3	110	2	33972531
Pubmed	ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors.	ETV1 ETV5	2.97e-05	3	110	2	22425584
Pubmed	PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro.	ETV1 ETV5	2.97e-05	3	110	2	12871699
Pubmed	Novel RNA hybridization method for the in situ detection of ETV1, ETV4, and ETV5 gene fusions in prostate cancer.	ETV1 ETV5	2.97e-05	3	110	2	25203299
Pubmed	OC-3, a novel mammalian member of the ONECUT class of transcription factors.	ONECUT2 ONECUT1	2.97e-05	3	110	2	11944891
Pubmed	PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO(3) cotransport.	SLC4A7 DLG4	2.97e-05	3	110	2	23183381
Pubmed	Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders.	SRCIN1 DLG4	2.97e-05	3	110	2	28713243
Pubmed	Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.	SRCIN1 DLG4	2.97e-05	3	110	2	25678324
Pubmed	Differential expression patterns of the PEA3 group transcription factors through murine embryonic development.	ETV1 ETV5	2.97e-05	3	110	2	9285689
Pubmed	The role of Pea3 group transcription factors in esophageal squamous cell carcinoma.	ETV1 ETV5	2.97e-05	3	110	2	21689625
Pubmed	Expression patterns of the Ets transcription factors from the PEA3 group during early stages of mouse development.	ETV1 ETV5	2.97e-05	3	110	2	11578874
Pubmed	Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.	SHANK1 DLG4	2.97e-05	3	110	2	10433268
Pubmed	OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6.	ONECUT2 ONECUT1	2.97e-05	3	110	2	9915796
Pubmed	Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.	ETV1 ETV5	2.97e-05	3	110	2	28161714
Pubmed	Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.	TSC2 MECP2	2.97e-05	3	110	2	28041914
Pubmed	ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility.	ONECUT2 ONECUT1	2.97e-05	3	110	2	31049588
Pubmed	Anti-sense morpholino oligonucleotide assay shows critical involvement for NF-kappaB activation in the production of Wnt-1 protein by HepG2 cells: oncology implications.	WNT1 RELA	2.97e-05	3	110	2	18461473
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TACC2 DENND4C WAC RBM6 NAV2 TJP2 OTUD4 ACIN1 SPEN	3.29e-05	503	110	9	16964243
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	RBM33 BAZ1B MECP2 JMJD1C WAC ACIN1 SPEN	3.42e-05	283	110	7	30585729
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	TACC2 DENND1A EHD4 PIKFYVE COBL PEAK1 MAP3K21	3.57e-05	285	110	7	34369648
Pubmed	Onecut1 is essential for horizontal cell genesis and retinal integrity.	ONECUT2 ONECUT1 BSN	3.93e-05	21	110	3	23926259
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TOR1AIP2 SLC4A7 LMTK2 BAZ1B TACC2 UBOX5 TJP2 OTUD4 ACIN1 PEAK1 AGRN ARHGAP21 STK25	3.96e-05	1084	110	13	11544199
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TOR1AIP2 ZNF536 POLRMT KIAA1549 BAZ1B MECP2 TRIM66 FOXP4 ZNF469 DLG4 RERE TCF7L1 BAHCC1	5.32e-05	1116	110	13	31753913
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 ARHGEF12 TSC2 TRIP11 LZTS1 OTUD4 DLG4 SSH2 BSN AGRN ARHGAP21 MAPK8IP2	5.55e-05	963	110	12	28671696
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ARHGEF12 DENND4C MAST4 COBL PEAK1 ARHGAP21	5.58e-05	209	110	6	36779422
Pubmed	IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses.	ARHGEF12 DLG4	5.92e-05	4	110	2	18164504
Pubmed	Pathogenicity of lupus anti-ribosomal P antibodies: role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model.	DLG4 BSN	5.92e-05	4	110	2	25709106
Pubmed	β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.	ETV1 ETV5	5.92e-05	4	110	2	26627735
Pubmed	Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2.	ONECUT2 ONECUT1	5.92e-05	4	110	2	12971999
Pubmed	Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF.	ETV1 ETV5	5.92e-05	4	110	2	24089499
Pubmed	The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity.	ETV1 ETV5	5.92e-05	4	110	2	20062082
Pubmed	Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.	ONECUT2 ONECUT1	5.92e-05	4	110	2	15159395
Pubmed	TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.	TRPM1 BSN	5.92e-05	4	110	2	19966281
Pubmed	ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer.	ETV1 ETV5	5.92e-05	4	110	2	28408625
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	SRCIN1 CBLB PIKFYVE DLG4 PEAK1 BSN	7.05e-05	218	110	6	33378226
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	RALGAPA1 SLC4A7 DCBLD1 KIAA1549 MICALL1 NAV2 COBL PEAK1 ARHGAP21	8.47e-05	569	110	9	30639242
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RALGAPA1 KIAA1549 TSC2 DENND1A DENND4C CEP72 TJP2 MAP3K21	8.99e-05	446	110	8	24255178
Pubmed	The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.	ARHGEF12 DLG4 AGRN	9.52e-05	28	110	3	24448406
Pubmed	An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer.	ETV1 ETV5	9.85e-05	5	110	2	27783944
Pubmed	Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.	SHANK1 DLG4	9.85e-05	5	110	2	16606358
Pubmed	IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.	SHANK1 BSN	9.85e-05	5	110	2	21940441
Pubmed	MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2.	ONECUT2 ONECUT1	9.85e-05	5	110	2	19913497
Pubmed	Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95.	SHANK1 DLG4	9.85e-05	5	110	2	15255944
Pubmed	Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.	ETV1 ETV5 AUTS2	1.06e-04	29	110	3	20615956
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	TOR1AIP2 RBM33 POLRMT BAZ1B TRIP11 JMJD1C RBM6 AUTS2	1.06e-04	457	110	8	32344865
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RBM33 BAZ1B ARHGAP17 TACC2 TRIP11 PIKFYVE RBM6 BSN SPEN	1.08e-04	588	110	9	38580884
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	RALGAPA1 ZNF536 SLC4A7 RBM33 MXRA8 ARHGAP17 JMJD1C DENND4C PIKFYVE TJP2	1.15e-04	733	110	10	34672954
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	ZNF536 L3MBTL1 SACS	1.30e-04	31	110	3	27798109
Pubmed	The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration.	WNT1 ETV1 HOXB4	1.30e-04	31	110	3	30470704
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF536 BAZ1B FOXP4 AUTS2 RERE SPEN BAHCC1	1.31e-04	351	110	7	38297188
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	TRIP11 WAC SACS SCMH1 ADAM33 CACNA1G RERE SPEN AGRN	1.39e-04	608	110	9	16713569
Pubmed	A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.	ZNF536 TACC2 DENND1A	1.43e-04	32	110	3	23049088
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	JMJD1C HOXB4 SCMH1	1.43e-04	32	110	3	37167859
Pubmed	A census of human transcription factors: function, expression and evolution.	ONECUT2 FOXN1 ETV1 KIAA1549 RELA ONECUT1 HOXB4 FOXP4 RERE TCF7L1 CREB3L2	1.47e-04	908	110	11	19274049
Pubmed	Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.	FOXN1 WNT1	1.47e-04	6	110	2	12379851
Pubmed	MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.	EHD4 MICALL1	1.47e-04	6	110	2	19864458
Pubmed	Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site.	ETV1 ETV5	1.47e-04	6	110	2	15466854
Pubmed	Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.	ONECUT2 ONECUT1	1.47e-04	6	110	2	23867227
Pubmed	The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.	ONECUT2 ONECUT1	1.47e-04	6	110	2	15381696
Pubmed	The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.	ONECUT2 ONECUT1	1.47e-04	6	110	2	12781686
Pubmed	Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening.	CBLB TJP2	1.47e-04	6	110	2	12829691
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	ONECUT2 ETV1 ETV5 ACVR1B HOXB4 FLRT2	1.52e-04	251	110	6	29031500
Pubmed	Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.	WNT1 KDM6B HOXB4	1.72e-04	34	110	3	32553152
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RBM33 POLRMT SRCIN1 MMP20 NAV2 TJP2 COBL ARHGAP21	1.89e-04	497	110	8	36774506
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RBM33 KIAA1549 TRIP11 JMJD1C PEAK1 ARHGAP21	1.96e-04	263	110	6	34702444
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	ARHGEF12 DLG4 ARHGAP21	2.04e-04	36	110	3	26053890
Pubmed	Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain.	APCDD1 WNT1 ETV5	2.04e-04	36	110	3	22278924
Pubmed	A multipotent progenitor domain guides pancreatic organogenesis.	BAZ1B ETV5 ONECUT1 FOXP4	2.05e-04	91	110	4	17609113
Pubmed	Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.	ETV1 DLG4	2.06e-04	7	110	2	17959791
Pubmed	Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity.	SHANK1 DLG4	2.06e-04	7	110	2	17898222
Pubmed	Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells.	SHANK1 DLG4	2.06e-04	7	110	2	15207857
Pubmed	The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development.	ETV1 ETV5	2.06e-04	7	110	2	18977342
Pubmed	The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse.	DLG4 BSN	2.06e-04	7	110	2	18353676
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 TSC2 MED13L KDM6B TRIP11 CCDC85A WAC TRIM66 SACS DLG4 LTBP3 ARHGAP21 MAPK8IP2	2.15e-04	1285	110	13	35914814
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	ETV1 ETV5 NAV2 AUTS2	2.32e-04	94	110	4	23431145
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	POLRMT RBM6 TJP2 ACIN1 COBL ARHGAP21	2.44e-04	274	110	6	34244482
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	C14orf93 TSC2 TRPM1 MRPL49 SPEN TCF7L1 RBM17	2.74e-04	396	110	7	26687479
Interaction	SFN interactions	RALGAPA1 SLC4A7 LMTK2 TSC2 TRIP11 DENND1A DENND4C MAST4 NAV2 TJP2 COBL SSH2 PEAK1 MAP3K21 ARHGAP21	4.76e-06	692	109	15	int:SFN
Interaction	TOP3B interactions	SZT2 RBM33 POLRMT LMTK2 ARHGAP17 TSC2 MED13L KDM6B IDUA DENND1A MICALL1 PIKFYVE HOXB4 NAV2 OTUD4 ACIN1 COBL LTBP3 SPEN AGRN ARHGAP21 BAHCC1	1.07e-05	1470	109	22	int:TOP3B
Interaction	RHOB interactions	RALGAPA1 SLC4A7 ARHGEF12 DCBLD1 KIAA1549 ARHGAP17 TSC2 ACVR1B MICALL1 LZTS1 TJP2 COBL FLRT2 PEAK1 MAP3K21 ARHGAP21	1.14e-05	840	109	16	int:RHOB
Interaction	YWHAG interactions	RALGAPA1 SLC4A7 LMTK2 ARHGAP17 TSC2 TRIP11 DENND1A DENND4C MICALL1 MAST4 NAV2 TJP2 ACIN1 COBL DLG4 SSH2 PEAK1 MAP3K21 ARHGAP21	3.73e-05	1248	109	19	int:YWHAG
Interaction	YWHAE interactions	RALGAPA1 SLC4A7 TSC2 TACC2 SRCIN1 MMP20 TRIP11 DENND1A DENND4C MICALL1 MAST4 NAV2 TJP2 DLG4 SSH2 PEAK1 MAP3K21 AGRN ARHGAP21	4.07e-05	1256	109	19	int:YWHAE
Cytoband	10p12.1	WAC ARHGAP21 APBB1IP	6.48e-05	32	111	3	10p12.1
Cytoband	Xp21.1	FAM47A FAM47C FAM47DP	7.79e-05	34	111	3	Xp21.1
Cytoband	17q21.31	DBF4B LRRC37A2 LRRC37A	1.06e-03	82	111	3	17q21.31
Cytoband	Ensembl 112 genes in cytogenetic band chrXp21	FAM47A FAM47C FAM47DP	1.14e-03	84	111	3	chrXp21
GeneFamily	PDZ domain containing	SHANK1 ARHGEF12 MAST4 TJP2 DLG4 ARHGAP21	3.70e-05	152	74	6	1220
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	L3MBTL1 SCMH1	5.84e-04	9	74	2	1263
GeneFamily	CUT class homeoboxes and pseudogenes	ONECUT2 ONECUT1	5.84e-04	9	74	2	527
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	RBM6 RBM17	3.62e-03	22	74	2	579
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6B JMJD1C	4.30e-03	24	74	2	485
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND1A DENND4C	4.66e-03	25	74	2	504
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	TJP2 DLG4	5.04e-03	26	74	2	904
GeneFamily	Sterile alpha motif domain containing	SHANK1 L3MBTL1 SCMH1	5.63e-03	88	74	3	760
GeneFamily	ETS transcription factor family	ETV1 ETV5	5.83e-03	28	74	2	534
GeneFamily	PHD finger proteins	BAZ1B KMT2E TRIM66	5.99e-03	90	74	3	88
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	LMTK2 TSC2 SACS PCIF1	6.48e-03	181	74	4	694
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	BAZ1B MED13L CBLB MECP2 PIKFYVE MAST4 SACS AUTS2 OTUD4 SPEN CREB3L2	5.74e-08	300	110	11	M8702
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	RBM33 AFF3 ARHGEF12 KIAA1549 TSC2 SRCIN1 ACVR1B MED13L KMT2E CCDC85A EHD4 MAST4 CNTNAP4 AUTS2 OTUD4 CACNA1G SSH2 BSN MAPK8IP2	1.65e-07	1106	110	19	M39071
Coexpression	GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP	SHANK1 SZT2 TSC2 IDUA SCMH1 ACIN1 TCF7L1	2.15e-05	199	110	7	M7254
Coexpression	GSE7831_1H_VS_4H_INFLUENZA_STIM_PDC_DN	APCDD1 AFF3 TACC2 MED13L TRIP11 ZNF706 PEAK1	2.15e-05	199	110	7	M6964
Coexpression	GSE24292_WT_VS_PPARG_KO_MACROPHAGE_DN	RALGAPA1 ARHGAP17 MED13L JMJD1C DENND4C EHD4 ADAM33	2.22e-05	200	110	7	M8054
Coexpression	GSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_TREG_UP	RBM33 MED13L CBLB NAV2 OTUD4 AGRN CREB3L2	2.22e-05	200	110	7	M4313
Coexpression	LAKE_ADULT_KIDNEY_C28_INTERSTITIUM	MED13L CBLB SCMH1 NAV2 AUTS2	3.16e-05	86	110	5	M39247
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G6	MECP2 PIKFYVE MAST4 AUTS2 OTUD4 CREB3L2	3.45e-05	145	110	6	M1810
Coexpression	GSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_TREG_CD4_TCELL_DN	GARIN5A KDM6B IDUA SCMH1 DLG4 RERE	5.01e-05	155	110	6	M8944
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	SLC4A7 BAZ1B MED13L CBLB MECP2 PIKFYVE SACS RBM6 TJP2 OTUD4 FLRT2 SPEN CREB3L2	6.28e-05	856	110	13	M4500
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC37A3 AFF3 MED13L DENND1A SCMH1 RBM6 AUTS2 RERE SSH2	1.85e-09	199	111	9	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	MED13L DENND1A JMJD1C MAST4 SCMH1 RBM6 RERE SSH2	2.88e-08	192	111	8	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC37A3 AFF3 MED13L SCMH1 NAV2 AUTS2 RERE PEAK1	3.66e-08	198	111	8	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	3.49e-07	180	111	7	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	4.85e-07	189	111	7	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	5.39e-07	192	111	7	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	AFF3 TACC2 MAST4 NAV2 AUTS2 COBL TCF7L1	5.39e-07	192	111	7	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	5.59e-07	193	111	7	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	5.59e-07	193	111	7	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	5.59e-07	193	111	7	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFF3 ETV1 LMTK2 ETV5 TACC2 MAST4 AUTS2	5.78e-07	194	111	7	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	5.78e-07	194	111	7	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	AFF3 ARHGEF12 TACC2 MAST4 NAV2 AUTS2 COBL	5.99e-07	195	111	7	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	AFF3 ARHGEF12 TACC2 MAST4 NAV2 AUTS2 COBL	5.99e-07	195	111	7	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC37A3 AFF3 MED13L SCMH1 NAV2 AUTS2 RERE	6.20e-07	196	111	7	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	6.63e-07	198	111	7	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2 TCF7L1	6.63e-07	198	111	7	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	SLC4A7 TACC2 CBLB EHD4 MAST4 NAV2 OTUD4	6.63e-07	198	111	7	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF536 MXRA8 SSC5D NAV2 ADAM33 PEAK1	5.13e-06	175	111	6	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ZNF536 CD248 AFF3 ETV1 CACNA1G LTBP3	7.27e-06	186	111	6	e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	AFF3 ETV1 ETV5 MAST4 AUTS2 TCF7L1	7.50e-06	187	111	6	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV1 ETV5 MAST4 NAV2 AUTS2 MAP3K21	7.73e-06	188	111	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 LRRC37A3 JMJD1C AUTS2 RERE TCF7L1	8.21e-06	190	111	6	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2	8.46e-06	191	111	6	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	AFF3 ETV1 ARHGEF12 TACC2 MAST4 AUTS2	8.72e-06	192	111	6	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	AFF3 ETV1 ETV5 TACC2 MAST4 AUTS2	8.72e-06	192	111	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFF3 ETV5 TACC2 MAST4 AUTS2 TCF7L1	8.72e-06	192	111	6	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	proximal-mesenchymal-Myofibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF536 MXRA8 SSC5D HOXB4 FLRT2 BSN	1.01e-05	197	111	6	ab21baea931ff134cf5a7ee369c091230988108b
ToppCell	proximal-mesenchymal-Myofibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF536 MXRA8 SSC5D HOXB4 FLRT2 BSN	1.01e-05	197	111	6	15f2f169758a07143fc7d1bdb58d0b4d750a0be4
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 CD248 ETV1 TJP2 ADAM33 CREB3L2	1.01e-05	197	111	6	26475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCell	proximal-3-mesenchymal-Myofibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF536 MXRA8 SSC5D HOXB4 FLRT2 BSN	1.01e-05	197	111	6	c59b64674fb4aaa945c1df7e4a9a3605c7cd2b75
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AFF3 MXRA8 ETV1 IDUA CACNA1G LTBP3	1.01e-05	197	111	6	3fe665c0277d091290b63f0dd24c0c6536a45309
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 CD248 ETV1 TJP2 ADAM33 CREB3L2	1.01e-05	197	111	6	155e63b33302a87393ace699b2f6d73abe9c5763
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 CD248 ETV1 TJP2 ADAM33 CREB3L2	1.04e-05	198	111	6	a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 CBLB NAV2 FLRT2 PEAK1 CREB3L2	1.04e-05	198	111	6	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CD248 MXRA8 SSC5D ZNF469 ADAM33 FLRT2	1.07e-05	199	111	6	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	SRCIN1 CCDC85A AHSP MAST4 COBL MAPK8IP2	1.10e-05	200	111	6	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	SLC4A7 SRCIN1 FOXP4 CNTNAP4 AUTS2 CACNA1G	1.10e-05	200	111	6	f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Striatum / BrainAtlas - Mouse McCarroll V32	SHANK1 ZNF536 HTR1A CNTNAP4 CACNA1G	2.09e-05	133	111	5	d5326a6ccada5ae6d3e8f7d4a858c90050e23c5b
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	SZT2 CBLB JMJD1C SPEN TCF7L1	3.60e-05	149	111	5	768877bade04ca0321593b8470b5011ad8270431
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CBLB NAV2 FLRT2 PEAK1 CREB3L2	4.34e-05	155	111	5	82e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CBLB NAV2 FLRT2 PEAK1 CREB3L2	4.34e-05	155	111	5	979c1d53b435a82c57d16707eed8ba7346326866
ToppCell	Striatum-Neuronal-Inhibitory\|Striatum / BrainAtlas - Mouse McCarroll V32	SHANK1 ZNF536 HTR1A CNTNAP4 CACNA1G	4.62e-05	157	111	5	c41ff3fe9de7187575114febfe9bd8733366fb8a
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 ARHGEF12 ADAM33 CACNA1G AGRN	5.05e-05	160	111	5	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 ARHGEF12 ADAM33 CACNA1G AGRN	5.05e-05	160	111	5	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 ARHGEF12 ADAM33 CACNA1G AGRN	5.20e-05	161	111	5	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SZT2 ETV1 SRCIN1 AHSP MAST4	5.36e-05	162	111	5	64353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SZT2 ETV1 SRCIN1 AHSP MAST4	5.52e-05	163	111	5	9f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C14orf93 FOXP4 ADAM33 DLG4 FLRT2	6.02e-05	166	111	5	49103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCell	wk_20-22-Hematologic-Myeloid-GMP\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	DBF4B ACVR1B DENND1A LRRC37A FAM149B1	6.02e-05	166	111	5	d96e88e73a40205f32cebd7e54ca1ff09ee1e7e8
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	FOXP4 ZNF469 LZTS1 ADAM33 TCF7L1	6.19e-05	167	111	5	9062577a4b7902c9a888d706589d1b05221c0fa8
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	DBF4B RELA L3MBTL1 MRPL49 STK25	6.37e-05	168	111	5	ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 MXRA8 SSC5D ADAM33 FLRT2	6.55e-05	169	111	5	bb43abad2c049b7f4d307737347290e01b3339a3
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 MXRA8 SSC5D ADAM33 FLRT2	6.55e-05	169	111	5	5f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 MXRA8 SSC5D ADAM33 FLRT2	6.55e-05	169	111	5	8bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	ARHGEF12 TACC2 CCDC85A NAV2 COBL	6.73e-05	170	111	5	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ETV1 KIAA1549 SRCIN1 BSN MAPK8IP2	7.31e-05	173	111	5	f31e738c2b3b319fb40b0b16b2393a51c9a8999c
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 KIAA1549 DENND4C MAST4 BSN	7.52e-05	174	111	5	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	LRRC37A3 DBF4B MED13L LRRC37A COBL	7.72e-05	175	111	5	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 MXRA8 ETV1 CBLB AUTS2	8.82e-05	180	111	5	280ff5c8f292be1b88120db5ff1788b750644856
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 MXRA8 ETV1 CBLB AUTS2	8.82e-05	180	111	5	fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD248 MXRA8 SSC5D LRRC37A ADAM33	9.53e-05	183	111	5	06a68fa2be36448064f4668be24a5b85ad85c6e8
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFF3 ETV1 TACC2 MAST4 AUTS2	9.53e-05	183	111	5	6847c1252d6bb105524f812658112517fd351eab
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF536 MXRA8 CBLB CCDC85A TCF7L1	9.53e-05	183	111	5	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	AFF3 ETV1 TACC2 MAST4 AUTS2	9.78e-05	184	111	5	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RALGAPA1 AFF3 KDM6B KMT2E PIKFYVE	1.00e-04	185	111	5	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	CD248 MXRA8 SSC5D ADAM33 FLRT2	1.00e-04	185	111	5	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD248 APCDD1 LZTS1 PEAK1 AGRN	1.03e-04	186	111	5	db4d9ac89cc1e55062ba888b3410b773340595dd
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	LMTK2 CCDC85A NAV2 COBL AGRN	1.03e-04	186	111	5	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SHANK1 FOXP4 DLG4 BSN MAPK8IP2	1.03e-04	186	111	5	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RALGAPA1 MED13L CBLB JMJD1C SPEN	1.08e-04	188	111	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 TACC2 SSC5D ADAM33 FLRT2	1.08e-04	188	111	5	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ZNF536 TACC2 SSC5D NAV2 FLRT2	1.08e-04	188	111	5	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD248 APCDD1 MXRA8 SSC5D ADAM33	1.11e-04	189	111	5	d531399749409d614adca13d181830c6e3287508
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 TACC2 SSC5D NAV2 FLRT2	1.11e-04	189	111	5	da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 CBLB NAV2 PEAK1 CREB3L2	1.14e-04	190	111	5	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	AFF3 ETV1 TACC2 MAST4 COBL	1.14e-04	190	111	5	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MXRA8 ETV1 CBLB NAV2 PEAK1	1.14e-04	190	111	5	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 CBLB NAV2 PEAK1 CREB3L2	1.14e-04	190	111	5	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ETV1 ETV5 MAST4 AUTS2 MAP3K21	1.16e-04	191	111	5	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	AFF3 ETV1 TACC2 MAST4 AUTS2	1.16e-04	191	111	5	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD248 SSC5D CACNA1G FLRT2 TCF7L1	1.16e-04	191	111	5	24dc77ee8de01b42559f92721655f4281b114e17
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFF3 TACC2 MAST4 AUTS2 COBL	1.16e-04	191	111	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD248 AFF3 ETV1 CBLB AUTS2	1.19e-04	192	111	5	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 MXRA8 ETV1 CBLB AUTS2	1.19e-04	192	111	5	9333aba0d04203ccccad78d82bf6359922f810a7
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MED13L DENND1A JMJD1C RERE SSH2	1.22e-04	193	111	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ZNF536 CD248 ETV5 SSC5D HOXB4	1.22e-04	193	111	5	2f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	MECP2 TRIM66 DLG4 BSN MAPK8IP2	1.22e-04	193	111	5	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	AFF3 DCBLD1 ETV5 CBLB RERE	1.25e-04	194	111	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AFF3 TACC2 MAST4 NAV2 COBL	1.25e-04	194	111	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZNF536 APCDD1 ETV1 DCBLD1 ETV5	1.25e-04	194	111	5	fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 MXRA8 COBL ADAM33 FLRT2	1.25e-04	194	111	5	0e315c63407fa00643722a7d6138b1502f79b10d
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 MXRA8 COBL ADAM33 FLRT2	1.25e-04	194	111	5	c2990d6eda3954dc01913bf3910df79f06e0010a
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	ARHGEF12 TACC2 MAST4 NAV2 COBL	1.28e-04	195	111	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 CD248 MXRA8 ETV1 HOXB4	1.28e-04	195	111	5	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CD248 MXRA8 ETV1 HOXB4 ADAM33	1.28e-04	195	111	5	2eed0332e338d6f0dbcb399d9d36c4611d491b0a
ToppCell	E17.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZNF536 CD248 MXRA8 ETV1 HOXB4	1.28e-04	195	111	5	1daddd801bd4596fffbdb822fc326d5127c96004
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	AFF3 ETV1 DCBLD1 ETV5 RERE	1.28e-04	195	111	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	APCDD1 SSC5D ADAM33 CACNA1G LTBP3	1.28e-04	195	111	5	c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCell	E17.5-Mesenchymal-myocytic_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZNF536 CD248 MXRA8 ETV1 HOXB4	1.28e-04	195	111	5	01a750d660993017af00736215cbcff2de5909c1
Disease	Intellectual Disability	RALGAPA1 ZNF142 AFF3 MED13L KDM6B KMT2E MECP2 WAC SACS ACIN1 DLG4 CACNA1G	1.05e-07	447	109	12	C3714756
Disease	sexual dimorphism measurement	RALGAPA1 ZNF142 CWH43 CD248 BAZ1B TSC2 TRIP11 JMJD1C SSC5D SCMH1 PCIF1 RBM6 OTUD4 LTBP3 BSN	1.39e-05	1106	109	15	EFO_0021796
Disease	household income	HTR1A AFF3 KMT2E UBOX5 JMJD1C MAST4 RBM6 BSN	1.79e-05	304	109	8	EFO_0009695
Disease	Neurodevelopmental Disorders	MED13L KMT2E MECP2 WAC DLG4	2.52e-05	93	109	5	C1535926
Disease	lifestyle measurement	HTR1A CWH43 AFF3 ONECUT1 DENND1A AUTS2 BAHCC1	2.78e-05	235	109	7	EFO_0010724
Disease	neuroimaging measurement	SZT2 AFF3 ARHGEF12 TACC2 IDUA DENND1A JMJD1C DENND4C ZNF469 MAST4 NAV2 RERE SSH2 BAHCC1	4.02e-05	1069	109	14	EFO_0004346
Disease	cortical thickness	ZNF536 ARHGEF12 TACC2 IDUA DENND1A JMJD1C MICALL1 ZNF469 MAST4 NAV2 AUTS2 RERE SSH2 ARHGAP21	6.21e-05	1113	109	14	EFO_0004840
Disease	Seizures	ZNF142 HTR1A AFF3 TSC2 KMT2E MECP2	1.63e-04	218	109	6	C0036572
Disease	reaction time measurement	KIF27 WNT1 LRRC37A2 TACC2 MED13L CCDC85A CEP72 NAV2 AUTS2 RERE	1.67e-04	658	109	10	EFO_0008393
Disease	age-related hearing impairment	FOXN1 ZNF536 HTR1A ACVR1B MED13L AUTS2 DLG4	2.06e-04	324	109	7	EFO_0005782
Disease	age of onset of asthma	AFF3 RBM6 LTBP3 RERE	2.14e-04	79	109	4	OBA_2001001
Disease	neuroticism measurement, cognitive function measurement	HTR1A KIF27 CD248 DENND1A JMJD1C CCDC85A NAV2 AUTS2 RERE	2.57e-04	566	109	9	EFO_0007660, EFO_0008354
Disease	C-reactive protein measurement, high density lipoprotein cholesterol measurement	BAZ1B JMJD1C PCIF1	2.70e-04	34	109	3	EFO_0004458, EFO_0004612
Disease	bipolar disorder (implicated_via_orthology)	ETV1 ETV5	2.81e-04	7	109	2	DOID:3312 (implicated_via_orthology)
Disease	cognitive function measurement, self reported educational attainment	HTR1A AFF3 JMJD1C SCMH1 CNTNAP4 AUTS2 BSN	3.59e-04	355	109	7	EFO_0004784, EFO_0008354
Disease	Williams Syndrome	BAZ1B DLG4	3.73e-04	8	109	2	C0175702
Disease	alkaline phosphatase measurement	RALGAPA1 ONECUT2 BAZ1B TSC2 ONECUT1 JMJD1C WAC PCIF1 DLG4 LTBP3 ARHGAP21 CREB3L2	3.77e-04	1015	109	12	EFO_0004533
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	HTR1A KIF27 ONECUT1 TRIM66 AUTS2 RERE SSH2	4.16e-04	364	109	7	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	cortical surface area measurement	ZNF536 APCDD1 ARHGEF12 MED13L IDUA DENND1A ZNF469 MAST4 NAV2 AUTS2 RERE SSH2 TCF7L1 ARHGAP21	4.38e-04	1345	109	14	EFO_0010736
Disease	lipid measurement, intermediate density lipoprotein measurement	BAZ1B JMJD1C PCIF1 DLG4	4.51e-04	96	109	4	EFO_0004529, EFO_0008595
Disease	body fat percentage	RALGAPA1 HTR1A KIF27 ONECUT1 TRIM66 AUTS2 RERE SSH2	4.67e-04	488	109	8	EFO_0007800
Disease	total cholesterol measurement, intermediate density lipoprotein measurement	BAZ1B JMJD1C PCIF1 DLG4	5.06e-04	99	109	4	EFO_0004574, EFO_0008595
Disease	reticulocyte measurement	AFF3 KDM6B JMJD1C EHD4 PIKFYVE FOXP4 ZNF469 PCIF1 RBM6 BSN ARHGAP21 APBB1IP	5.22e-04	1053	109	12	EFO_0010700
Disease	waist-hip ratio	APCDD1 AFF3 ONECUT1 TRIP11 TLCD2 JMJD1C TRIM66 SSC5D MAST4 RBM6 LTBP3 RERE ARHGAP21	5.98e-04	1226	109	13	EFO_0004343
Disease	bone density	WNT1 TACC2 MED13L IDUA COBL RERE TCF7L1	6.08e-04	388	109	7	EFO_0003923
Disease	free cholesterol measurement, intermediate density lipoprotein measurement	BAZ1B JMJD1C PCIF1 DLG4	6.10e-04	104	109	4	EFO_0008591, EFO_0008595
Disease	forced expiratory volume	AFF3 ETV1 ONECUT1 TRIP11 JMJD1C SSC5D CEP72 LZTS1 SCMH1 OTUD4	6.96e-04	789	109	10	EFO_0004314
Disease	macula measurement	DENND1A NAV2 TJP2 COBL TRPM1	6.97e-04	189	109	5	EFO_0008375
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	HTR1A WNT1 AFF3 JMJD1C RBM6 AUTS2 BSN	7.06e-04	398	109	7	EFO_0003756, EFO_0003888, EFO_0004337
Disease	Tremor	ZNF142 HTR1A	7.28e-04	11	109	2	C0040822
Disease	platelet crit	SLC4A7 AFF3 ETV1 ARHGEF12 KDM6B JMJD1C EHD4 MAST4 OTUD4 RERE GP1BA	8.04e-04	952	109	11	EFO_0007985
Disease	comparative body size at age 10, self-reported	ZNF536 LRRC37A2 ETV5 MED13L TRIP11 MAST4 RERE	9.66e-04	420	109	7	EFO_0009819
Disease	obesity (implicated_via_orthology)	WNT1 ETV1 ETV5 MED13L TCF7L1	1.24e-03	215	109	5	DOID:9970 (implicated_via_orthology)
Disease	Williams-Beuren syndrome (implicated_via_orthology)	BAZ1B DLG4	1.38e-03	15	109	2	DOID:1928 (implicated_via_orthology)
Disease	diet measurement	ZNF536 BAZ1B ONECUT1 UBOX5 JMJD1C TRIM66 ZNF469 SCMH1 RBM6 AUTS2 RERE	1.75e-03	1049	109	11	EFO_0008111
Disease	Muscle hypotonia	RALGAPA1 MECP2	1.77e-03	17	109	2	C0026827
Disease	Profound Mental Retardation	MED13L KDM6B MECP2 CACNA1G	1.79e-03	139	109	4	C0020796
Disease	Mental Retardation, Psychosocial	MED13L KDM6B MECP2 CACNA1G	1.79e-03	139	109	4	C0025363
Disease	Mental deficiency	MED13L KDM6B MECP2 CACNA1G	1.79e-03	139	109	4	C0917816
Disease	FEV/FEC ratio	AFF3 ETV1 DCBLD1 ACVR1B JMJD1C CEP72 NAV2 OTUD4 ADAM33 LTBP3 SSH2 TCF7L1	1.95e-03	1228	109	12	EFO_0004713
Disease	platelet component distribution width	SLC4A7 DBF4B ETV5 JMJD1C MICALL1 RBM6 ADAM33 TCF7L1 GP1BA	1.97e-03	755	109	9	EFO_0007984
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	JMJD1C PCIF1 DLG4	1.98e-03	67	109	3	EFO_0008595, EFO_0020946
Disease	Tourette syndrome, schizophrenia	ZNF536 RERE	1.99e-03	18	109	2	EFO_0004895, MONDO_0005090
Disease	Prostatic Neoplasms	ONECUT2 ETV1 LMTK2 ETV5 WAC FOXP4 LZTS1 SPEN	2.07e-03	616	109	8	C0033578
Disease	Malignant neoplasm of prostate	ONECUT2 ETV1 LMTK2 ETV5 WAC FOXP4 LZTS1 SPEN	2.07e-03	616	109	8	C0376358
Disease	alcohol consumption measurement	ONECUT2 AFF3 DENND1A MICALL1 TRIM66 MAST4 AUTS2 COBL RERE PEAK1 AGRN BAHCC1	2.14e-03	1242	109	12	EFO_0007878
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	SHANK1 ZNF536 TSC2 RELA	2.25e-03	148	109	4	C0279702
Disease	cognitive function measurement	ZNF536 HTR1A SZT2 DBF4B AFF3 KMT2E JMJD1C MAST4 SCMH1 RBM6 CNTNAP4 AUTS2 ARHGAP21	2.44e-03	1434	109	13	EFO_0008354
Disease	autism spectrum disorder (implicated_via_orthology)	SHANK1 TSC2 CNTNAP4 DLG4	2.48e-03	152	109	4	DOID:0060041 (implicated_via_orthology)
Disease	myeloid white cell count	ETV1 ARHGEF12 KMT2E JMJD1C EHD4 ADAM33 RERE SSH2 TCF7L1 APBB1IP	2.49e-03	937	109	10	EFO_0007988
Disease	mean arterial pressure	SLC4A7 SZT2 ARHGEF12 AUTS2 RERE BAHCC1 RBM17	2.57e-03	499	109	7	EFO_0006340
Disease	atrial fibrillation	DCBLD1 JMJD1C SCMH1 NAV2 SPEN ARHGAP21	2.59e-03	371	109	6	EFO_0000275
Disease	mean reticulocyte volume	AFF3 IDUA JMJD1C WAC ZNF469 PCIF1 RBM6 OTUD4 ARHGAP21	2.87e-03	799	109	9	EFO_0010701
Disease	Autistic Disorder	SHANK1 TSC2 KMT2E MECP2 JMJD1C	2.88e-03	261	109	5	C0004352
Disease	anxiety disorder (implicated_via_orthology)	HTR1A TSC2	2.98e-03	22	109	2	DOID:2030 (implicated_via_orthology)
Disease	diastolic blood pressure, systolic blood pressure	SLC4A7 RBM33 KMT2E CBLB EHD4 HOXB4 TCF7L1 CREB3L2	3.46e-03	670	109	8	EFO_0006335, EFO_0006336
Disease	Epilepsy, Cryptogenic	TSC2 MECP2 AUTS2	3.51e-03	82	109	3	C0086237
Disease	Awakening Epilepsy	TSC2 MECP2 AUTS2	3.51e-03	82	109	3	C0751111
Disease	Aura	TSC2 MECP2 AUTS2	3.51e-03	82	109	3	C0236018
Disease	anthropometric measurement	TRIP11 ZNF469 LTBP3 BSN	3.55e-03	168	109	4	EFO_0004302

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEASSPPPHPQLHSE	ACIN1	421	Q9UKV3
PPSHTSDTPAEKALP	AFF3	801	P51826
ILPSEPTPHSAPHAL	BAHCC1	876	Q9P281
RDFLKSHELPSHPPP	AHSP	86	Q9NZD4
LRVPSGHLKEPEHPS	ACVR1B	106	P36896
PRTSSKPHKHLPPAA	BAZ1B	461	Q9UIG0
PPVIPATHPALSRDH	CD248	466	Q9HCU0
SPISPTHPHSKAPQI	CD248	631	Q9HCU0
KPEPPKAPVSHHFLE	FAM47DP	176	A6NHR8
HDPAVPRAPHAPKSS	APBB1IP	501	Q7Z5R6
PRAPHPSHTSQPVAK	AGRN	1286	O00468
VAPLKAALHPSHPDP	CNTNAP4	1176	Q9C0A0
NSHEPSSHPEKPLPA	ADAM33	781	Q9BZ11
ESVPASLKEGRPHHP	CEP72	161	Q9P209
SLSHPPPDLPGTHLI	FLRT2	241	O43155
HPKHLSTPSSVSPEP	ARHGEF12	626	Q9NZN5
LDPPHTVHSAPKEVA	RAD54B	96	Q9Y620
PHAHSPVPPGIKSIQ	RBM33	1041	Q96EV2
ASIPPVAEGKAHPPT	OTUD4	951	Q01804
IHEPAPLPGPLKDHT	KIAA1549	1371	Q9HCM3
PPKTRVSHLHREPPE	FAM47C	286	Q5HY64
GVSHLHPEPPKTLVS	FAM47C	326	Q5HY64
HPEPPKTLVSSLHPE	FAM47C	331	Q5HY64
PPETGVSHLHPELPK	FAM47C	766	Q5HY64
VSPKHPEVTLPHPDQ	LRRC37A3	636	O60309
IPTEPDSADSHAHPP	MED13L	1661	Q71F56
SHQLHPAPPDKPKEQ	LZTS1	146	Q9Y250
VSPKHPEVTLPHPDQ	LRRC37A2	636	A6NM11
VSPKHPEVTLPHPDQ	LRRC37A	636	A6NMS7
SDPPALPDSTEAKPH	MUC20	456	Q8N307
EPHRPLKITAHSSPP	JMJD1C	931	Q15652
GTPPSSAPDPKNHHI	KDM6B	1311	O15054
PSPSVEEPHKHRPTT	MAPK8IP2	126	Q13387
PHPPSPSEIHKVGSS	BSN	716	Q9UPA5
PPARHSLIEHSKPPG	CBLB	826	Q13191
ELPPIHSSLAPPSGH	KIF27	1301	Q86VH2
APKHLFVSQSHSPPP	L3MBTL1	396	Q9Y468
LHQLPPDPEKAPITH	PEAK1	26	Q9H792
THTPKPDRAFPAHLP	ETV1	156	P50549
PLPPISTVSDKFPHH	ONECUT1	111	Q9UBC0
PLPPISTVSDKFHHP	ONECUT2	156	O95948
TPAKTQPAPPHISHH	AUTS2	411	Q8WXX7
HLENPPKSSTPHTPV	KMT2E	1446	Q8IZD2
HTPQKLVPPDKPADS	LMTK2	1016	Q8IWU2
PAVPKSSSEPAVHAP	MICALL1	531	Q8N3F8
PHLVPPSHRKSLPKA	EHD4	526	Q9H223
KPAPHHDVTVRVVPP	GARIN5A	31	Q6IPT2
SFAAPPKVSPPLSHH	FOXP4	261	Q8IVH2
PKVSPPLSHHTLPNG	FOXP4	266	Q8IVH2
HAPPPTKIKRELHSP	ETV5	81	P41161
PLHPSPSHSACKEPV	HOXB4	126	P17483
PTSPSHLTHFKPLTP	PIKFYVE	21	Q9Y2I7
HSAVDPLLPATDPHP	CEP104	356	O60308
IKHRGPSEVLPPHPE	PCIF1	186	Q9H4Z3
PKDAPHLLQPHSAPT	CACNA1G	2096	O43497
TPHPESPETPKADSL	GFY	96	I3L273
QALHPDPSKTPHPES	GFY	231	I3L273
LIPHDTTPLHEEVSP	DBF4B	521	Q8NFT6
AHSSPPEEPGPLKES	C14orf93	116	Q9H972
APPPPGKAATLHVHS	COBL	21	O75128
SVSGPHPLPIEKHIS	DENND4C	336	Q5VZ89
VAKHSQPSPEPHSPT	DENND4C	961	Q5VZ89
SKEHLPLPSEAGPTP	HTR1A	301	P08908
HHPPILPPKADLTIG	APCDD1	276	Q8J025
PHPGSSPETLPKHVL	CCDC85A	296	Q96PX6
DEDTPPLEHSPAHLP	DLG4	16	P78352
PPVAPAEAPHLVHVD	IDUA	21	P35475
ESAAPSQHLLPHPKP	LTBP3	251	Q9NS15
PSPLHPHPICEVSKV	GP1BA	11	P07359
HSESSSHKPRPGPDP	MAST4	2186	O15021
HKLPIPDPGVSVHLS	DENND1A	136	Q8TEH3
HLSPEPPKTEVSHLH	FAM47A	386	Q5JRC9
PETQVSHPHPEHPKT	FAM47A	471	Q5JRC9
LHPEPPKAPESHQFS	FAM47A	556	Q5JRC9
TESGHPDSQKPPTHP	DCBLD1	676	Q8N8Z6
IPASPNTPVPIHHSK	SACS	1371	Q9NZJ4
PPEAHLPHSAAPARK	POLRMT	741	O00411
SPKEAPVDHLHLPPT	CREB3L2	191	Q70SY1
HHPPPEKLEEISPTS	FAM149B1	26	Q96BN6
HHSESPKAPVPLLPP	MECP2	371	P51608
TLPHAPHHKPSIPDL	MMP20	281	O60882
PIVKSEHHLLPSPEG	CWH43	511	Q9H720
LEHDTPIPKHLHTPG	SZT2	586	Q5T011
PPPPLKSHAQERHSG	RBM6	31	P78332
AFTPHSQPLPHPSLK	UBOX5	311	O94941
EPLDPDPSHSPSDKV	TOR1AIP2	111	Q8NFQ8
PSPKLHVPEKFEPTH	SLC4A7	881	Q9Y6M7
PAPHSHLPREVSPKK	MAP3K21	921	Q5TCX8
LPSEHGLEQPSHTPP	ARHGAP17	741	Q68EM7
SPLPAHTPPSHSAKL	FOXN1	491	O15353
KPVHSAAPILHVPPA	NAV2	16	Q8IVL1
VQHPIKPVVHPTATP	WAC	246	Q9BTA9
PPALKPLSSLSTHHP	RERE	966	Q9P2R6
LLSPTAHPLDHPPLD	SSC5D	1441	A1L4H1
LLPATRIPDPPKHEH	MRPL49	51	Q13405
LIESPADDSPPHHAP	SIGLEC12	536	Q96PQ1
FPPTIRPSPHSKLHK	STK25	321	O00506
PIRIFHKEPPSPSHN	SCMH1	151	Q96GD3
PSLLPASEHKVSPAP	SHANK1	2001	Q9Y566
PIKTHKPDPGTPQHT	TJP2	1121	Q9UDY2
HLESLKEPEPLHSPD	RALGAPA1	1466	Q6GYQ0
VLQSRPHPPSPGHEK	TLCD2	226	A6NGC4
HPPALPSKLPTEVNH	SPEN	2986	Q96T58
LHPQVLPLPHSSSPE	SSH2	1071	Q76I76
ASKAHPGPAPTPDHK	SRCIN1	951	Q9C0H9
SPPTHLSPEIDPKTG	TCF7L1	206	Q9HCS4
TPPHVAAGLKDPVPS	RBM17	71	Q96I25
SPPEPDETHDPKLQH	TACC2	1796	O95359
QHFESKHPKTPLPPE	ZNF706	56	Q9Y5V0
HPPSPTEHEVDVKTP	ZNF469	2546	Q96JG9
ELDLHKLAHTPAPPP	ZNF469	3101	Q96JG9
HIPPLPSATPSKNEE	TRPM1	16	Q7Z4N2
HSVPDVAHPVPSPKP	ZNF536	246	O15090
LKHPSHRPPASTLSP	nan	31	Q8NA96
ESHPSIPPPKLSVHD	TRIP11	1871	Q15643
PEDPAHKPPSPHDLV	WNT1	276	P04628
SPTEAPKKHHLDPVP	ZNF142	991	P52746
SLKGQVPPPSIHPAH	TRIM66	331	O15016
EEPSPPHNSKHNKSP	ARHGAP21	1501	Q5T5U3
LVTKDPPHRPHPHEL	RELA	76	Q04206
SNPSLPLVHPPSHSK	TSC2	1761	P49815
PLVHPPSHSKAPAQT	TSC2	1766	P49815
VFHLTVAEPHAEPPP	MXRA8	286	Q9BRK3