Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ganglioside GT1b binding	MAG RTN4R	8.35e-05	3	106	2	GO:1905576
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRB2 GABRD GRIN2A GRIN2C	2.39e-04	57	106	4	GO:1904315
GeneOntologyMolecularFunction	ganglioside binding	MAG RTN4R	2.76e-04	5	106	2	GO:0035594
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GABRB2 GABRD GRIN2A GRIN2C	2.91e-04	60	106	4	GO:0099529
GeneOntologyMolecularFunction	K63-linked polyubiquitin modification-dependent protein binding	OTUD7B PARP10 OTUD7A	3.46e-04	26	106	3	GO:0070530
GeneOntologyMolecularFunction	transmitter-gated channel activity	GABRB2 GABRD GRIN2A GRIN2C	3.96e-04	65	106	4	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GABRB2 GABRD GRIN2A GRIN2C	3.96e-04	65	106	4	GO:0022824
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GABRB2 GABRD GRIN2A GRIN2C	6.83e-04	75	106	4	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GABRB2 GABRD GRIN2A GRIN2C	7.54e-04	77	106	4	GO:0005230
GeneOntologyMolecularFunction	leukotriene C4 gamma-glutamyl transferase activity	GGT6 GGT5	7.66e-04	8	106	2	GO:0103068
GeneOntologyMolecularFunction	glutamate-gated calcium ion channel activity	GRIN2A GRIN2C	7.66e-04	8	106	2	GO:0022849
GeneOntologyMolecularFunction	NMDA glutamate receptor activity	GRIN2A GRIN2C	7.66e-04	8	106	2	GO:0004972
GeneOntologyMolecularFunction	glutathione hydrolase activity	GGT6 GGT5	9.81e-04	9	106	2	GO:0036374
GeneOntologyBiologicalProcess	protein K11-linked deubiquitination	OTUD7B OTUD7A VCPIP1	1.59e-05	10	107	3	GO:0035871
HumanPheno	Atrophy/Degeneration affecting the cerebrum	GABRB2 GABRD MAG COG2 SZT2 GRIN2A OSGEP PIGQ LIMK1 NALCN TINF2 GLE1 ASNS PCYT2 UQCRC1	2.62e-05	733	34	15	HP:0007369
HumanPheno	Cerebral hypoplasia	GABRB2 GABRD MAG COG2 SZT2 GRIN2A OSGEP PIGQ LIMK1 C2CD3 NALCN TINF2 GLE1 ASNS PCYT2 UQCRC1	3.19e-05	844	34	16	HP:0006872
HumanPheno	Brain atrophy	GABRB2 GABRD MAG COG2 SZT2 GRIN2A OSGEP PIGQ LIMK1 NALCN TINF2 GLE1 ASNS PCYT2 UQCRC1	7.74e-05	802	34	15	HP:0012444
HumanPheno	Brain very small	GABRB2 GABRD MAG COG2 SZT2 GRIN2A OSGEP PIGQ LIMK1 NALCN TINF2 GLE1 ASNS PCYT2 UQCRC1	7.74e-05	802	34	15	HP:0001322
HumanPheno	Cerebral atrophy	GABRB2 GABRD COG2 SZT2 GRIN2A OSGEP PIGQ LIMK1 NALCN TINF2 GLE1 ASNS PCYT2 UQCRC1	9.70e-05	718	34	14	HP:0002059
HumanPheno	Tremor	GABRB2 GABRD MAG KMT2B NOP56 SZT2 SPTBN2 ADAMTS13 PIGQ LIMK1 KCNC1 ASNS UQCRC1	1.26e-04	639	34	13	HP:0001337
Domain	Cezanne-2	OTUD7B OTUD7A	3.25e-05	2	107	2	IPR033477
Domain	OTU	OTUD7B OTUD7A VCPIP1	5.01e-05	13	107	3	PF02338
Domain	OTU	OTUD7B OTUD7A VCPIP1	7.91e-05	15	107	3	PS50802
Domain	OTU_dom	OTUD7B OTUD7A VCPIP1	7.91e-05	15	107	3	IPR003323
Domain	NMDAR2_C	GRIN2A GRIN2C	9.72e-05	3	107	2	PF10565
Domain	NMDAR2_C	GRIN2A GRIN2C	9.72e-05	3	107	2	IPR018884
Domain	Spectrin_bsu	SPTBN2 SPTBN4	1.94e-04	4	107	2	IPR016343
Domain	LRRNT	PODNL1 RTN4R TRIL AMIGO3 GP5	2.50e-04	98	107	5	IPR000372
Domain	LRRNT	PODNL1 RTN4R TRIL AMIGO3 GP5	2.50e-04	98	107	5	SM00013
Domain	GGT_peptidase	GGT6 GGT5	6.70e-04	7	107	2	IPR000101
Domain	Znf_A20	OTUD7B OTUD7A	6.70e-04	7	107	2	IPR002653
Domain	G_GLU_TRANSPEPTIDASE	GGT6 GGT5	6.70e-04	7	107	2	PS00462
Domain	ZF_A20	OTUD7B OTUD7A	6.70e-04	7	107	2	PS51036
Domain	zf-A20	OTUD7B OTUD7A	6.70e-04	7	107	2	PF01754
Domain	G_glu_transpept	GGT6 GGT5	6.70e-04	7	107	2	PF01019
Domain	ZnF_A20	OTUD7B OTUD7A	6.70e-04	7	107	2	SM00259
Domain	PH_dom-like	DAB2IP SPTBN2 APBA3 WDFY4 SPTBN4 PLD2 TNS1 ACAP3 FAM43A	7.67e-04	426	107	9	IPR011993
Domain	Ntn_hydrolases_N	GGT6 GGT5 ASNS	8.80e-04	33	107	3	IPR029055
Domain	PH_dom-spectrin-type	SPTBN2 SPTBN4	1.14e-03	9	107	2	IPR001605
Domain	ANF_lig-bd_rcpt	TAS1R3 GRIN2A GRIN2C	1.23e-03	37	107	3	IPR001828
Domain	ANF_receptor	TAS1R3 GRIN2A GRIN2C	1.23e-03	37	107	3	PF01094
Domain	Peripla_BP_I	TAS1R3 GRIN2A GRIN2C	1.44e-03	39	107	3	IPR028082
Domain	PTB	APBA3 TNS1 FAM43A	1.55e-03	40	107	3	SM00462
Domain	PTB/PI_dom	APBA3 TNS1 FAM43A	1.66e-03	41	107	3	IPR006020
Domain	-	DAB2IP SPTBN2 APBA3 SPTBN4 PLD2 TNS1 ACAP3 FAM43A	1.85e-03	391	107	8	2.30.29.30
Domain	LRR_8	PODNL1 RTN4R TRIL AMIGO3 GP5	3.04e-03	171	107	5	PF13855
Domain	Leu-rich_rpt_typical-subtyp	PODNL1 RTN4R TRIL AMIGO3 GP5	3.53e-03	177	107	5	IPR003591
Domain	LRR_TYP	PODNL1 RTN4R TRIL AMIGO3 GP5	3.53e-03	177	107	5	SM00369
Domain	Channel_four-helix_dom	CACNA1F KCNC1 NALCN	4.27e-03	57	107	3	IPR027359
Domain	-	CACNA1F KCNC1 NALCN	4.27e-03	57	107	3	1.20.120.350
Domain	Iontro_rcpt	GRIN2A GRIN2C	4.69e-03	18	107	2	IPR001320
Domain	Lig_chan-Glu_bd	GRIN2A GRIN2C	4.69e-03	18	107	2	PF10613
Domain	Iono_rcpt_met	GRIN2A GRIN2C	4.69e-03	18	107	2	IPR001508
Domain	Glu/Gly-bd	GRIN2A GRIN2C	4.69e-03	18	107	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIN2A GRIN2C	4.69e-03	18	107	2	SM00918
Domain	Lig_chan	GRIN2A GRIN2C	4.69e-03	18	107	2	PF00060
Domain	PBPe	GRIN2A GRIN2C	4.69e-03	18	107	2	SM00079
Domain	LRR	PODNL1 RTN4R TRIL AMIGO3 GP5	6.02e-03	201	107	5	PS51450
Domain	CH	SPTBN2 SPTBN4 MICALL2	6.17e-03	65	107	3	SM00033
Domain	Quino_amine_DH_bsu	WDR6 ANAPC4	6.97e-03	22	107	2	IPR011044
Domain	WD40_repeat_dom	WDFY4 GTF3C2 WDR6 TLE2 STRN4 ANAPC4	7.28e-03	297	107	6	IPR017986
Domain	LIM	LIMK1 MICALL2 FBLIM1	7.28e-03	69	107	3	PF00412
Domain	-	LIMK1 MICALL2 FBLIM1	7.58e-03	70	107	3	2.10.110.10
Domain	CH	SPTBN2 SPTBN4 MICALL2	7.58e-03	70	107	3	PF00307
Domain	Actinin_actin-bd_CS	SPTBN2 SPTBN4	7.61e-03	23	107	2	IPR001589
Pubmed	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.	TPO SPTBN2 GLE1 TLE2 MROH7 KLHL34	7.87e-06	149	109	6	22664934
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2B NOP56 SPTBN2 CCT6A GTF3C2 ANAPC1 WDR6 STRN4 VCPIP1 HDLBP	9.33e-06	549	109	10	38280479
Pubmed	Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C.	GRIN2A GRIN2C	9.73e-06	2	109	2	9512392
Pubmed	NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons.	GRIN2A GRIN2C	9.73e-06	2	109	2	16885526
Pubmed	Axonal protective effects of the myelin-associated glycoprotein.	MAG RTN4R	9.73e-06	2	109	2	19158290
Pubmed	Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A.	GRIN2A GRIN2C	9.73e-06	2	109	2	9427357
Pubmed	Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells.	GRIN2A GRIN2C	9.73e-06	2	109	2	25788577
Pubmed	A role for Nogo receptor in macrophage clearance from injured peripheral nerve.	MAG RTN4R	9.73e-06	2	109	2	17329206
Pubmed	N-methyl-D-aspartate receptor subtype 2C is not involved in circadian oscillation or photoic entrainment of the biological clock in mice.	GRIN2A GRIN2C	9.73e-06	2	109	2	10972963
Pubmed	NMDA receptor 2 (NR2) C-terminal control of NR open probability regulates synaptic transmission and plasticity at a cerebellar synapse.	GRIN2A GRIN2C	9.73e-06	2	109	2	12427824
Pubmed	Characterization of the interaction between DNA gyrase inhibitor and DNA gyrase of Escherichia coli.	MAG RTN4R	9.73e-06	2	109	2	11777918
Pubmed	Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.	MAG RTN4R	9.73e-06	2	109	2	19052207
Pubmed	Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.	GRIN2A GRIN2C	9.73e-06	2	109	2	8987814
Pubmed	NMDA receptor subunits GluRepsilon1, GluRepsilon3 and GluRzeta1 are enriched at the mossy fibre-granule cell synapse in the adult mouse cerebellum.	GRIN2A GRIN2C	9.73e-06	2	109	2	11422443
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTUD7B OTUD7A VCPIP1	2.80e-05	19	109	3	23827681
Pubmed	Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits.	GRIN2A GRIN2C	2.91e-05	3	109	2	15519237
Pubmed	Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.	GRIN2A GRIN2C	2.91e-05	3	109	2	9718984
Pubmed	Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures.	GRIN2A GRIN2C	2.91e-05	3	109	2	18685090
Pubmed	Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel.	GRIN2A GRIN2C	2.91e-05	3	109	2	8267632
Pubmed	Intracellular domains of NR2 alter calcium-dependent inactivation of N-methyl-D-aspartate receptors.	GRIN2A GRIN2C	2.91e-05	3	109	2	11854440
Pubmed	Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth.	MAG RTN4R	2.91e-05	3	109	2	12160746
Pubmed	The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits α1, β2, and δ along their extrasynaptic cell membrane.	GABRB2 GABRD	2.91e-05	3	109	2	24055402
Pubmed	Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule.	GRIN2A GRIN2C	2.91e-05	3	109	2	7929101
Pubmed	Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions.	MAG RTN4R	2.91e-05	3	109	2	15121177
Pubmed	Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels.	GRIN2A GRIN2C	2.91e-05	3	109	2	9480759
Pubmed	Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells.	GRIN2A GRIN2C	2.91e-05	3	109	2	30056832
Pubmed	Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.	MAG RTN4R	2.91e-05	3	109	2	18411262
Pubmed	The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.	GABRB2 GABRD	2.91e-05	3	109	2	18079158
Pubmed	Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.	MAG RTN4R	2.91e-05	3	109	2	12089450
Pubmed	Genetical genomic determinants of alcohol consumption in rats and humans.	GABRB2 GABRD CYP2E1 GRIN2A GRIN2C	5.78e-05	130	109	5	19874574
Pubmed	Molecular diversity of the NMDA receptor channel.	GRIN2A GRIN2C	5.82e-05	4	109	2	1377365
Pubmed	Characterisation of the expression of NMDA receptors in human astrocytes.	GRIN2A GRIN2C	5.82e-05	4	109	2	21152063
Pubmed	Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum.	GRIN2A GRIN2C	5.82e-05	4	109	2	8699248
Pubmed	Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin.	LIMK1 PLD2	5.82e-05	4	109	2	17853892
Pubmed	Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons.	GRIN2A GRIN2C	5.82e-05	4	109	2	8965641
Pubmed	Differential assembly diversifies GABAA receptor structures and signalling.	GABRB2 GABRD	5.82e-05	4	109	2	35355020
Pubmed	Heteromeric NMDA receptors: molecular and functional distinction of subtypes.	GRIN2A GRIN2C	5.82e-05	4	109	2	1350383
Pubmed	GABAA Receptors and the Diversity in their Structure and Pharmacology.	GABRB2 GABRD	5.82e-05	4	109	2	28528665
Pubmed	NMDA receptor upregulation: molecular studies in cultured mouse cortical neurons after chronic antagonist exposure.	GRIN2A GRIN2C	5.82e-05	4	109	2	8601798
Pubmed	Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel.	GRIN2A GRIN2C	5.82e-05	4	109	2	9768843
Pubmed	Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.	GRIN2A GRIN2C	5.82e-05	4	109	2	36309015
Pubmed	Differential expression and co-assembly of NMDA zeta 1 and epsilon subunits in the mouse cerebellum during postnatal development.	GRIN2A GRIN2C	5.82e-05	4	109	2	8595214
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	GIPC2 KMT2B QPCTL SCAF8 KIAA2013 LENG8 CCT6A GTF3C2 MICALL2 ANAPC1 LNPEP STRN4 HELZ2 UQCRC1 HDLBP	6.82e-05	1497	109	15	31527615
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	XRN2 NOP56 SCAF8 OTUD7B CCT6A HDLBP	7.05e-05	220	109	6	24550385
Pubmed	Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.	GRIN2A GRIN2C	9.67e-05	5	109	2	26919761
Pubmed	Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.	GRIN2A GRIN2C	9.67e-05	5	109	2	7518475
Pubmed	Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum.	GRIN2A GRIN2C	9.67e-05	5	109	2	7518474
Pubmed	Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit.	GRIN2A GRIN2C	9.67e-05	5	109	2	9147327
Pubmed	Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland.	GRIN2A GRIN2C	9.67e-05	5	109	2	8015722
Pubmed	Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain.	GRIN2A GRIN2C	9.67e-05	5	109	2	15003177
Pubmed	GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions.	GRIN2A GRIN2C	9.67e-05	5	109	2	7723623
Pubmed	Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.	GRIN2A GRIN2C	9.67e-05	5	109	2	12082569
Pubmed	Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.	GRIN2A GRIN2C	9.67e-05	5	109	2	21945132
Pubmed	Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex.	GRIN2A GRIN2C	9.67e-05	5	109	2	11488959
Pubmed	Developmental changes in distribution of NMDA receptor channel subunit mRNAs.	GRIN2A GRIN2C	9.67e-05	5	109	2	1493227
Pubmed	N-methyl-D-aspartic acid receptor structure and function.	GRIN2A GRIN2C	9.67e-05	5	109	2	8036251
Pubmed	NMDA receptor activation by HIV-Tat protein is clade dependent.	GRIN2A GRIN2C	9.67e-05	5	109	2	19020013
Pubmed	Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.	GRIN2A GRIN2C	9.67e-05	5	109	2	26875626
Pubmed	A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.	MAG RTN4R	9.67e-05	5	109	2	12426574
Pubmed	Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina.	GRIN2A GRIN2C	9.67e-05	5	109	2	7510577
Pubmed	Modified N-methyl-D-aspartate receptor subunit expression emerges in reeler Purkinje cells after accomplishment of the adult wild-type expression.	GRIN2A GRIN2C	9.67e-05	5	109	2	9004271
Pubmed	Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene.	GRIN2A GRIN2C	9.67e-05	5	109	2	8756432
Pubmed	The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.	ANAPC1 ANAPC4	9.67e-05	5	109	2	19826416
Pubmed	GABAA receptors: structure, function, pharmacology, and related disorders.	GABRB2 GABRD	9.67e-05	5	109	2	34417930
Pubmed	Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins.	GRIN2A GRIN2C	9.67e-05	5	109	2	18233995
Pubmed	Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.	MAG RTN4R	9.67e-05	5	109	2	12839991
Pubmed	Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord.	GRIN2A GRIN2C	9.67e-05	5	109	2	7929904
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	SZT2 OTUD7B OTUD7A HELZ2 VCPIP1	1.03e-04	147	109	5	29576527
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	GABRB2 MAG EMILIN3 LENG8 C2CD3 GTF3C2 GLE1 RBM14	1.08e-04	462	109	8	31138677
Pubmed	Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.	GRIN2A GRIN2C KCNC1	1.14e-04	30	109	3	18603407
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GABRB2 GABRD GRIN2A GRIN2C	1.26e-04	81	109	4	22723691
Pubmed	BCS1L is expressed in critical regions for neural development during ontogenesis in mice.	YJEFN3 UQCRC1	1.45e-04	6	109	2	17049929
Pubmed	A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.	GRIN2A GRIN2C	1.45e-04	6	109	2	23665428
Pubmed	Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse.	GRIN2A GRIN2C	1.45e-04	6	109	2	8996814
Pubmed	NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.	GRIN2A GRIN2C	1.45e-04	6	109	2	15317856
Pubmed	Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.	GRIN2A GRIN2C	1.45e-04	6	109	2	25760043
Pubmed	In vivo assembly of the axon initial segment in motor neurons.	SPTBN2 SPTBN4	1.45e-04	6	109	2	23728480
Pubmed	Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.	GRIN2A GRIN2C	1.45e-04	6	109	2	9458051
Pubmed	Amygdala gene expression of NMDA and GABA(A) receptors in patients with mesial temporal lobe epilepsy.	GABRB2 GRIN2A	1.45e-04	6	109	2	20848605
Pubmed	Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.	SPTBN2 SPTBN4	1.45e-04	6	109	2	16687515
Pubmed	Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate.	CCT6A ANAPC1 ANAPC4	1.53e-04	33	109	3	25306918
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	XRN2 KMT2B SCAF8 OTUD7B PITPNM1 ANAPC1 HELZ2 RBM14 VCPIP1 HDLBP	1.65e-04	774	109	10	15302935
Pubmed	The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.	ANAPC1 ANAPC4	2.02e-04	7	109	2	27939943
Pubmed	Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington's Disease.	GABRB2 GABRD	2.02e-04	7	109	2	28676743
Pubmed	HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.	GRIN2A GRIN2C	2.02e-04	7	109	2	22940423
Pubmed	Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus.	GRIN2A GRIN2C	2.02e-04	7	109	2	12103442
Pubmed	Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.	MAG RTN4R	2.02e-04	7	109	2	12951563
Pubmed	Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways.	MAG RTN4R	2.02e-04	7	109	2	26335717
Pubmed	Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.	GRIN2A GRIN2C	2.02e-04	7	109	2	23267846
Pubmed	Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.	GRIN2A GRIN2C	2.02e-04	7	109	2	19036954
Pubmed	Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.	GABRB2 GABRD	2.02e-04	7	109	2	17021187
Pubmed	Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.	OTUD7B OTUD7A	2.02e-04	7	109	2	18281465
Pubmed	Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.	GRIN2A GRIN2C	2.02e-04	7	109	2	22833210
Pubmed	Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.	CCT6A ANAPC1 ANAPC4	2.15e-04	37	109	3	26811472
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	QPCTL NOP56 PEG10 SPTBN2 TRAPPC8 MRPL39 DNAJC14 GTF3C2 SNX6 WDR6 LNPEP MAP4K5 ASNS HDLBP	2.31e-04	1487	109	14	33957083
Pubmed	Personal receptor repertoires: olfaction as a model.	OR52R1 OR52E1 OR51G1	2.33e-04	38	109	3	22908908
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	GIPC2 CMYA5 YJEFN3 CCT6A DNAJC14 MICALL2	2.47e-04	277	109	6	30745168
Pubmed	Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.	GRIN2A GRIN2C	2.69e-04	8	109	2	8804048
Pubmed	Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.	ANAPC1 ANAPC4	2.69e-04	8	109	2	20686030
Pubmed	The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.	GRIN2A GRIN2C	2.69e-04	8	109	2	8845955
GeneFamily	OTU domain containing	OTUD7B OTUD7A VCPIP1	5.63e-05	17	81	3	669
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN2 SPTBN4	4.10e-04	7	81	2	1113
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2A GRIN2C	4.10e-04	7	81	2	1201
GeneFamily	CD molecules\|Gamma-glutamyltransferases	GGT6 GGT5	1.50e-03	13	81	2	564
GeneFamily	Anaphase promoting complex \|Tetratricopeptide repeat domain containing	ANAPC1 ANAPC4	1.74e-03	14	81	2	402
GeneFamily	LIM domain containing	LIMK1 MICALL2 FBLIM1	2.35e-03	59	81	3	1218
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRB2 GABRD	3.23e-03	19	81	2	563
Drug	acamprosate	GABRB2 GABRD CYP2E1 GRIN2A GRIN2C GGT5	1.34e-06	74	107	6	CID000071158
Disease	developmental disorder of mental health (implicated_via_orthology)	DAB2IP GABRB2 GABRD GRIN2A GRIN2C	7.19e-07	49	101	5	DOID:0060037 (implicated_via_orthology)
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN2 SPTBN4	6.93e-05	4	101	2	DOID:0050882 (implicated_via_orthology)
Disease	level of Phosphatidylcholine (15:0_18:1) in blood serum	GTF3C2 MAP4K5	1.15e-04	5	101	2	OBA_2045064
Disease	level of Phosphatidylcholine (16:0_18:1) in blood serum	GTF3C2 MAP4K5	1.72e-04	6	101	2	OBA_2045070
Disease	level of Phosphatidylcholine (16:1_18:0) in blood serum	GTF3C2 MAP4K5	1.72e-04	6	101	2	OBA_2045081
Disease	Schizophrenia	GABRB2 GABRD MAG CACNA1F CYP2E1 RTN4R SPTBN2 GRIN2A GRIN2C CMYA5 PITPNM1	2.22e-04	883	101	11	C0036341
Disease	Developmental delay (disorder)	SZT2 SPTBN2 PIGQ	2.78e-04	37	101	3	C0424605
Disease	triacylglycerol 51:2 measurement	GTF3C2 MAP4K5	3.20e-04	8	101	2	EFO_0021483
Disease	level of Triacylglycerol (49:2) in blood serum	GTF3C2 MAP4K5	3.20e-04	8	101	2	OBA_2045162
Disease	cathepsin F measurement	MAP4K5 CCDC87	4.11e-04	9	101	2	EFO_0022038
Disease	interleukin 6 receptor subunit alpha measurement	BOLA1 OTUD7B	8.83e-04	13	101	2	EFO_0008187
Disease	triacylglycerol 52:2 measurement	PTPRU GTF3C2 MAP4K5	8.97e-04	55	101	3	EFO_0010414
Disease	triacylglycerol 46:2 measurement	GTF3C2 MAP4K5	1.03e-03	14	101	2	EFO_0010402
Disease	Global developmental delay	SZT2 SPTBN2 PIGQ PCYT2	1.15e-03	133	101	4	C0557874
Disease	level of Phosphatidylcholine (14:0_18:2) in blood serum	GTF3C2 MAP4K5	1.53e-03	17	101	2	OBA_2045063
Disease	triacylglycerol 48:1 measurement	GTF3C2 MAP4K5	1.53e-03	17	101	2	EFO_0010404
Disease	Schizophrenia	RTN4R RBM12	1.71e-03	18	101	2	cv:C0036341
Disease	renal system measurement	SCAF8 MICALL2	2.12e-03	20	101	2	EFO_0004742
Disease	Ewing sarcoma	XRN2 FAM135B	2.12e-03	20	101	2	EFO_0000174
Disease	triacylglycerol 46:1 measurement	GTF3C2 MAP4K5	2.12e-03	20	101	2	EFO_0010401
Disease	triacylglycerol 48:2 measurement	GTF3C2 MAP4K5	2.56e-03	22	101	2	EFO_0010405

Protein segments in the cluster

Peptide	Gene	Start	Entry
LIRGLVLDHGARHPD	CCT6A	206	P40227
AHGLELRVPFLDHRF	ASNS	411	P08243
AGEVLLHRLASFHRV	ANAPC4	41	Q9UJX5
RPLHLACRRGHAAVV	ASB10	296	Q8WXI3
PEHVVRALLNHGAVR	ASB10	346	Q8WXI3
DLAPVRGIRHAHRNL	ABCF3	541	Q9NUQ8
EVRVFHAHRLLLGLH	BTBD17	76	A6NE02
AIIHRPHAREQLGFC	APBA3	486	O96018
VALIGDAAHRVHPLA	COQ6	361	Q9Y2Z9
ADVRELHPGLLAHRA	ACAP3	661	Q96P50
LHPGLLAHRAARARD	ACAP3	666	Q96P50
RAPARRLVFHAQLAH	GIPC2	36	Q8TF65
ELHPRVGDLILAHLH	GLE1	511	Q53GS7
RFEGLSPLQRHRLVH	BOLA1	76	Q9Y3E2
HKHVVFLEPGRRGLN	AMIGO3	451	Q86WK7
LLGVVTRHPAAGHRL	CCDC87	381	Q9NVE4
RDFVDGPIHHRALLI	BMPR1B	116	O00238
ANHRPLFTHLAVRIG	ADAMTS13	586	Q76LX8
RLFINVAPHARIAIH	ADAMTS13	1326	Q76LX8
NPFIRHHSREGLVLG	MROH7	176	Q68CQ1
RDFFHGLRVDAVHLL	RBM12	321	Q9NTZ6
AIEALHGHELRPGRA	RBM14	51	Q96PK6
DDHIPFLRRGVPVLH	QPCTL	326	Q9NXS2
GDLPAFHAHRDRGII	CYP2E1	101	P05181
HRHTAEVLLAEIGRP	ANAPC1	1266	Q9H1A4
EFHVFVLAHVLRRPI	OTUD7B	296	Q6GQQ9
EDPIRAHSFRNHILG	CACNA1F	891	O60840
LDRNHSFRHILPGFR	DAB2IP	96	Q5VWQ8
RIRFRPSLFQHVGLH	MGAT4A	351	Q9UM21
RFGRNIPHFIHILLA	OR52E1	261	Q8NGJ3
HHPRAEEAFKVLRAA	DNAJC14	476	Q6Y2X3
GVIAEILRGVRLHFH	NOP56	116	O00567
RARVIHLHVPSAAGL	KLHL34	66	Q8N239
LLHFVPTREANGHRL	MAG	201	P20916
PLGAGVIERHVEHRV	LYSMD2	61	Q8IV50
HRLLDEGQSLHFPRI	HMCN2	1391	Q8NDA2
PLGVRAHHDVARLTA	HMCN2	4971	Q8NDA2
FQHGHSRRLRLEPLV	LENG8	516	Q96PV6
RDGLAFCAILHRHRP	MICALL2	31	Q8IY33
VHRLAERPYIIAGLH	PCYT2	236	Q99447
SLVHRFGEHLPRVVH	OR51G1	261	Q8NGK1
GGFLHALIHEVLIFR	OR5H2	156	Q8NGV7
RFGHATIHPLVRRLD	TPO	491	P07202
ARFGARHLPGHVLQE	PPM1N	111	Q8N819
HLPGRHTLFVRAMID	PEG10	356	Q86TG7
FIIRTVGRHFPGHLL	LNPEP	926	Q9UIQ6
LPRHSFGRNALERHV	GABRB2	446	P47870
AGQFPRLSLHFHLRR	GABRD	231	O14764
GARLLGIHHDAVIFL	KMT2B	2461	Q9UMN6
DHAGRTPLHLAVLRG	ANKRD65	71	E5RJM6
FHVFVLAHILRRPIV	OTUD7A	306	Q8TE49
LPGDTARHHRAVILD	OSGEP	41	Q9NPF4
RHTEHVFALRPVGFR	ITGB5	436	P18084
RHRDDALPFAHVAIA	UQCRC1	276	P31930
LVPAAGVRHISHRRF	PTPRU	231	Q92729
RFGHDVPRVVHILFA	OR52R1	266	Q8NGF1
HLSREGEAHELRLPA	KIR2DL4	156	Q99706
RALVLPHNHVAALGA	PODNL1	361	Q6PEZ8
KAFDTDIHALRPHRG	HAL	346	P42357
RHFVGLRVLGHTLRA	KCNC1	326	P48547
PAFRTLALRHLHGRV	LACTBL1	421	A8MY62
RRFHESLHLQGEAPL	C2CD3	1851	Q4AC94
AALPTLHLLHARFGR	GGT6	181	Q6P531
LFIIRHRFNEGVHPA	CMYA5	4031	Q8N3K9
RHRLEEAFRVALVGH	HYAL3	261	O43820
EAFRVALVGHRHPLP	HYAL3	266	O43820
RGGHVVAPVLSRFLH	GGT5	171	P36269
VHAEERALRRPGHLY	FAM43A	121	Q8N2R8
DAARRPLLAVATHVH	MBLAC2	71	Q68D91
RDHIIRALGQAFHPS	FBLIM1	251	Q8WUP2
HRNHIRSIAPGAFDR	GP5	226	P40197
ALGHEAHLQRLREAP	EMILIN3	276	Q9NT22
EFVPHHCRLLREVTG	COG2	281	Q14746
PFVRRHALHRNSLEG	FAM135B	716	Q49AJ0
ARELRVPVGFFSHIL	HELZ2	651	Q9BYK8
LVRPGIDHLGRRDHF	SCAF8	1071	Q9UPN6
GLAAHIQTHRFPDRI	MAP4K5	591	Q9Y4K4
LRGFGAHPARAARHL	PARP10	771	Q53GL7
AHPARAARHLVALLA	PARP10	776	Q53GL7
HHFVRALVRVCGGPR	INSL3	36	P51460
FFPLRHIHIVDGDRL	HS3ST1	206	O14792
HIHIVDGDRLIRDPF	HS3ST1	211	O14792
RIFLHGNRISHVPAA	RTN4R	61	Q9BZR6
FKEEFRRLHLPGHVL	SZT2	1756	Q5T011
RFQGVSLPVHLRAHF	MRPL39	296	Q9NYK5
LHGRSRIGHLADALV	PIGQ	296	Q9BRB3
PRADGLDHRIAAHIV	SPAG17	471	Q6Q759
IHFPEALGHVALRLV	PITPNM1	466	O00562
GLVLAALGLFVHHRD	TAS1R3	581	Q7RTX0
RDGLAFNAIVHKHRP	SPTBN2	206	O15020
LLRAHVRLHTGERPF	SP2	541	Q02086
LRAVAPGLVRYRHHE	TINF2	41	Q9BSI4
FHLDRILGFHRAPLV	FAM20B	151	O75063
LHPATFGHLGRLREL	TRIL	316	Q7L0X0
RPVHLDQAAFRTLGH	XRN2	806	Q9H0D6
HELVRHFLIETGPRG	TNS1	1521	Q9HBL0
EGHPLRFLTLVRHLA	WDFY4	1086	Q6ZS81
RHHFVAGRFVPDDVR	YJEFN3	266	A6XGL0
DGLAFNALIHRHRPD	SPTBN4	211	Q9H254
HIFGLANVLHRPIIL	VCPIP1	291	Q96JH7
PHVILREGLHGREIT	WDR6	691	Q9NNW5
VAAHPILRRDLNFHV	SNX6	151	Q9UNH7
LLDHRRVHTGERPFG	ZNF213	416	O14771
VARLKLFPHHIGELH	TRAPPC8	821	Q9Y2L5
VEPIHAFRAHRGPVL	STRN4	481	Q9NRL3
VRIHFVRGLASPLGH	GTF3C2	861	Q8WUA4
DVPLDHRVHARIIGA	HDLBP	1131	Q00341
GAGIPRHARQLHTLA	TLE2	441	Q04725
VVHGLPARDLARHFI	PLD2	546	O14939
ILALHLRAHPGAQAF	ZNF219	71	Q9P2Y4
VLLQEDFLAHRGRPH	KIAA2013	186	Q8IYS2
HRIFRPSDLIHGEVL	LIMK1	331	P53667
RDVIIHRVGPIHGIY	NALCN	1121	Q8IZF0
AALRIAHRAHPQGLV	AMDHD2	276	Q9Y303
PFLHSHRDDQRLVIG	GRIN2A	1366	Q12879
LHPGHALFLEGVRAV	GRIN2C	171	Q14957