Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D RASGRP3 RABGAP1 TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.70e-13	279	81	15	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D3E RASGRP1 RASGRP4 TBC1D3 TBC1D3H TBC1D3L TBC1D3D RASGRP3 RABGAP1 TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.67e-11	507	81	17	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D3E RASGRP1 RASGRP4 TBC1D3 TBC1D3H TBC1D3L TBC1D3D RASGRP3 RABGAP1 TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.67e-11	507	81	17	GO:0030695
GeneOntologyMolecularFunction	enzyme activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D RASGRP3 PEX12 RABGAP1 TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	7.09e-09	656	81	16	GO:0008047
GeneOntologyMolecularFunction	enzyme regulator activity	GSTP1 TBC1D3E RASGRP1 RASGRP4 TBC1D3 TBC1D3H TBC1D3L TBC1D3D RASGRP3 PEX12 RABGAP1 LXN TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	6.64e-07	1418	81	20	GO:0030234
GeneOntologyMolecularFunction	molecular function activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D RASGRP3 PEX12 RABGAP1 TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C GDNF TBC1D3B TBC1D3K TBC1D3F	7.33e-06	1233	81	17	GO:0140677
GeneOntologyMolecularFunction	diacylglycerol binding	RASGRP1 RASGRP4 RASGRP3	3.47e-05	16	81	3	GO:0019992
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CCR8 CX3CR1 CXCR1	1.07e-04	23	81	3	GO:0016493
GeneOntologyMolecularFunction	C-C chemokine binding	CCR8 CX3CR1 CXCR1	1.22e-04	24	81	3	GO:0019957
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CCR8 CX3CR1 CXCR1	1.56e-04	26	81	3	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CCR8 CX3CR1 CXCR1	1.56e-04	26	81	3	GO:0004950
GeneOntologyMolecularFunction	calcium ion binding	USP6 RASGRP1 RASGRP4 CGREF1 MAN1C1 RASGRP3 PCDH15 FSTL4 ADAMTS13 ZZEF1 PLS1	2.13e-04	749	81	11	GO:0005509
GeneOntologyMolecularFunction	chemokine binding	CCR8 CX3CR1 CXCR1	3.21e-04	33	81	3	GO:0019956
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E RASGRP1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I ARHGAP45 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.34e-16	109	81	13	GO:0090630
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3E RASGRP1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D MTOR RASGRP3 RABGAP1 TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.27e-14	335	81	17	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3E RASGRP1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I ARHGAP45 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.19e-11	244	81	13	GO:0043547
GeneOntologyBiologicalProcess	regulation of hydrolase activity	TBC1D3E RASGRP1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D MTOR RASGRP3 RABGAP1 LXN TBC1D3I ARHGAP45 ALS2CL TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	6.44e-09	878	81	18	GO:0051336
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3E RASGRP1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D MTOR TBC1D3I ARHGAP45 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	8.12e-09	499	81	14	GO:0051345
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	TBC1D3E RASGRP1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D MTOR TBC1D3I ARHGAP45 TBC1D3G TBC1D3C GDNF TBC1D3B TBC1D3K TBC1D3F	9.72e-06	1028	81	15	GO:0043085
Domain	TBC	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D RABGAP1 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	9.47e-19	49	78	12	SM00164
Domain	RabGAP-TBC	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D RABGAP1 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.70e-18	53	78	12	PF00566
Domain	TBC_RABGAP	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D RABGAP1 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	4.42e-18	55	78	12	PS50086
Domain	Rab-GTPase-TBC_dom	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D RABGAP1 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	4.42e-18	55	78	12	IPR000195
Domain	HEAT_REPEAT	PDS5B RELCH MROH1 MTOR HEATR1	1.09e-05	70	78	5	PS50077
Domain	EF_HAND_2	RASGRP1 RASGRP4 CGREF1 RASGRP3 FSTL4 ZZEF1 PLS1	5.07e-05	231	78	7	PS50222
Domain	EF_hand_dom	RASGRP1 RASGRP4 CGREF1 RASGRP3 FSTL4 ZZEF1 PLS1	5.21e-05	232	78	7	IPR002048
Domain	DAG/PE-bd	RASGRP1 RASGRP4 RASGRP3	8.83e-05	21	78	3	IPR020454
Domain	Ras-like_Gua-exchang_fac_N	RASGRP1 RASGRP4 RASGRP3	1.02e-04	22	78	3	IPR000651
Domain	RASGEF_NTER	RASGRP1 RASGRP4 RASGRP3	1.02e-04	22	78	3	PS50212
Domain	ZF_DAG_PE_1	RASGRP1 RASGRP4 RASGRP3 ARHGAP45	1.48e-04	64	78	4	PS00479
Domain	ZF_DAG_PE_2	RASGRP1 RASGRP4 RASGRP3 ARHGAP45	1.48e-04	64	78	4	PS50081
Domain	C1	RASGRP1 RASGRP4 RASGRP3 ARHGAP45	1.57e-04	65	78	4	SM00109
Domain	PE/DAG-bd	RASGRP1 RASGRP4 RASGRP3 ARHGAP45	1.67e-04	66	78	4	IPR002219
Domain	RASGEF_CAT	RASGRP1 RASGRP4 RASGRP3	2.37e-04	29	78	3	PS50009
Domain	RasGEF	RASGRP1 RASGRP4 RASGRP3	2.62e-04	30	78	3	PF00617
Domain	-	RASGRP1 RASGRP4 RASGRP3	2.62e-04	30	78	3	1.10.840.10
Domain	Ras_GEF_dom	RASGRP1 RASGRP4 RASGRP3	2.62e-04	30	78	3	IPR023578
Domain	RASGEF_cat_dom	RASGRP1 RASGRP4 RASGRP3	2.62e-04	30	78	3	IPR001895
Domain	RasGEF	RASGRP1 RASGRP4 RASGRP3	2.62e-04	30	78	3	SM00147
Domain	-	PDS5B RELCH MROH1 MTOR RTTN HEATR1	3.32e-04	222	78	6	1.25.10.10
Domain	CXCR4/ACKR2	CX3CR1 CXCR1	3.57e-04	7	78	2	IPR001277
Domain	EFh	RASGRP1 CGREF1 RASGRP3 ZZEF1 PLS1	5.22e-04	158	78	5	SM00054
Domain	-	RASGRP1 CGREF1 RASGRP3 FSTL4 ZZEF1 PLS1	7.79e-04	261	78	6	1.10.238.10
Domain	EF_Hand_1_Ca_BS	RASGRP1 CGREF1 RASGRP3 FSTL4 PLS1	8.29e-04	175	78	5	IPR018247
Domain	ARM-like	PDS5B RELCH MROH1 MTOR RTTN HEATR1	9.29e-04	270	78	6	IPR011989
Domain	EF-hand-dom_pair	RASGRP1 CGREF1 RASGRP3 FSTL4 ZZEF1 PLS1	1.27e-03	287	78	6	IPR011992
Domain	EF_HAND_1	RASGRP1 CGREF1 RASGRP3 FSTL4 PLS1	1.64e-03	204	78	5	PS00018
Domain	C1_1	RASGRP1 RASGRP4 RASGRP3	1.74e-03	57	78	3	PF00130
Domain	HEAT	MROH1 MTOR HEATR1	1.83e-03	58	78	3	IPR000357
Domain	HEAT_type_2	RELCH MROH1	2.25e-03	17	78	2	IPR021133
Domain	ARM-type_fold	PDS5B RELCH MROH1 MTOR RTTN HEATR1	2.93e-03	339	78	6	IPR016024
Domain	RasGEFN	RASGRP1 RASGRP3	3.12e-03	20	78	2	SM00229
Domain	RasGEF_N	RASGRP1 RASGRP3	3.43e-03	21	78	2	PF00618
Domain	Quino_amine_DH_bsu	FSTL4 ANAPC4	3.77e-03	22	78	2	IPR011044
Domain	EF-hand_1	CGREF1 RASGRP3 FSTL4 PLS1	3.77e-03	152	78	4	PF00036
Domain	Actinin_actin-bd_CS	SYNE1 PLS1	4.12e-03	23	78	2	IPR001589
Domain	ACTININ_2	SYNE1 PLS1	4.12e-03	23	78	2	PS00020
Domain	ACTININ_1	SYNE1 PLS1	4.12e-03	23	78	2	PS00019
Domain	Peptidase_M12B_ADAM-TS	ADAMTS15 ADAMTS13	4.48e-03	24	78	2	IPR013273
Domain	RASGEF	RASGRP1 RASGRP4	5.24e-03	26	78	2	PS00720
Domain	ACR	ADAMTS15 ADAMTS13	5.65e-03	27	78	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS15 ADAMTS13	5.65e-03	27	78	2	IPR006586
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E TBC1D3 TBC1D3H TBC1D3L PEX12 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K	1.72e-11	99	63	10	M46448
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.38e-30	11	81	11	16863688
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	USP6 TBC1D3 TBC1D3D TBC1D3F	2.73e-11	4	81	4	8406013
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	USP6 TBC1D3 TBC1D3D TBC1D3C	1.36e-10	5	81	4	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	USP6 TBC1D3 TBC1D3D TBC1D3F	1.36e-10	5	81	4	8471161
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3G TBC1D3B TBC1D3F	4.53e-10	74	81	7	16625196
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	4.86e-08	4	81	3	12359748
Pubmed	Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.	RASGRP1 RASGRP4 RASGRP3	1.21e-07	5	81	3	18172297
Pubmed	Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.	USP6 TBC1D3 RABGAP1 TBC1D3F	3.14e-06	43	81	4	19077034
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	BRIX1 PDS5B FLII ACTR5 MED16 HEATR1 THOC2 CDC27 ARHGAP45	4.27e-06	533	81	9	30554943
Pubmed	Exploring the role of miR-200 family in regulating CX3CR1 and CXCR1 in lung adenocarcinoma tumor microenvironment: implications for therapeutic intervention.	CX3CR1 CXCR1	5.36e-06	2	81	2	37770496
Pubmed	Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.	RASGRP1 RASGRP3	5.36e-06	2	81	2	28912101
Pubmed	HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population.	MPO GSTP1	5.36e-06	2	81	2	24786234
Pubmed	Two polymorphisms in the fracalkine receptor CX3CR1 are not associated with peripheral arterial disease.	CX3CR1 CXCR1	5.36e-06	2	81	2	12535747
Pubmed	GOLPH3 links the Golgi network to mTOR signaling and human cancer.	MTOR GOLPH3	5.36e-06	2	81	2	19624311
Pubmed	Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus.	CX3CR1 CXCR1	5.36e-06	2	81	2	31058213
Pubmed	The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.	RASGRP1 RASGRP4	5.36e-06	2	81	2	22262848
Pubmed	RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors.	RASGRP1 RASGRP3	5.36e-06	2	81	2	27465532
Pubmed	RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.	RASGRP1 RASGRP3	5.36e-06	2	81	2	16301621
Pubmed	Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.	OSBP2 NR6A1	1.60e-05	3	81	2	37903971
Pubmed	The role of RasGRPs in regulation of lymphocyte proliferation.	RASGRP1 RASGRP3	1.60e-05	3	81	2	16530850
Pubmed	A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.	RASGRP1 RASGRP3	1.60e-05	3	81	2	19100522
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	1.60e-05	3	81	2	21030649
Pubmed	GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.	MTOR GOLPH3	1.60e-05	3	81	2	19553991
Pubmed	Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny.	CCR8 CXCR1	1.60e-05	3	81	2	11007922
Pubmed	Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer.	MPO GSTP1	1.60e-05	3	81	2	17922231
Pubmed	Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice.	CX3CR1 CXCR1	1.60e-05	3	81	2	20335311
Pubmed	mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type.	MTOR CX3CR1	1.60e-05	3	81	2	27342766
Pubmed	RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.	RASGRP1 RASGRP3	1.60e-05	3	81	2	23308188
Pubmed	Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.	MTOR CX3CR1	1.60e-05	3	81	2	32567735
Pubmed	Mast cells in airway hyporesponsive C3H/HeJ mice express a unique isoform of the signaling protein Ras guanine nucleotide releasing protein 4 that is unresponsive to diacylglycerol and phorbol esters.	RASGRP1 RASGRP4	1.60e-05	3	81	2	12817022
Pubmed	GOLPH3 promotes glioblastoma cell migration and invasion via the mTOR-YB1 pathway in vitro.	MTOR GOLPH3	1.60e-05	3	81	2	25156912
Pubmed	Upregulation of RET induces perineurial invasion of pancreatic adenocarcinoma.	GDNF CX3CR1	3.20e-05	4	81	2	28092668
Pubmed	Association analysis of drug metabolizing enzyme gene polymorphisms in AIDS patients with cutaneous reactions to sulfonamides.	MPO GSTP1	3.20e-05	4	81	2	16297214
Pubmed	Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus.	CCR8 CX3CR1	3.20e-05	4	81	2	12551893
Pubmed	Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.	MPO GSTP1	3.20e-05	4	81	2	20663217
Pubmed	[Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].	MPO GSTP1	3.20e-05	4	81	2	17424838
Pubmed	Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.	CCR8 CX3CR1	3.20e-05	4	81	2	15534368
Pubmed	CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.	MPO GSTP1	3.20e-05	4	81	2	17980933
Pubmed	Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives.	CCR8 CX3CR1	3.20e-05	4	81	2	11804551
Pubmed	Human CLEC16A regulates autophagy through modulating mTOR activity.	MTOR CLEC16A	5.33e-05	5	81	2	28223137
Pubmed	Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene.	MPO RBL2	5.33e-05	5	81	2	9819431
Pubmed	Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.	RASGRP1 MTOR	5.33e-05	5	81	2	24336796
Pubmed	Ontogeny of Synovial Macrophages and the Roles of Synovial Macrophages From Different Origins in Arthritis.	CX3CR1 CXCR1	5.33e-05	5	81	2	31231364
Pubmed	Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.	MTOR RBL2	5.33e-05	5	81	2	19703998
Pubmed	Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes.	MPO GSTP1	5.33e-05	5	81	2	16157195
Pubmed	The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.	USP6 TBC1D3	5.33e-05	5	81	2	12612085
Pubmed	CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.	MPO GSTP1	5.33e-05	5	81	2	16195240
Pubmed	Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.	GSTP1 CDC27 ANAPC4	6.31e-05	33	81	3	32152539
Pubmed	Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease.	CX3CR1 CXCR1	7.99e-05	6	81	2	17672867
Pubmed	Negative regulation of mTOR activation by diacylglycerol kinases.	RASGRP1 MTOR	7.99e-05	6	81	2	21310925
Pubmed	Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.	MPO GSTP1	7.99e-05	6	81	2	17428572
Pubmed	Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs).	MPO GSTP1	7.99e-05	6	81	2	11943609
Pubmed	Exposure to low environmental levels of benzene: evaluation of micronucleus frequencies and S-phenylmercapturic acid excretion in relation to polymorphisms in genes encoding metabolic enzymes.	MPO GSTP1	7.99e-05	6	81	2	20951227
Pubmed	Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression.	CDC27 ANAPC4	7.99e-05	6	81	2	21335556
Pubmed	CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α.	CX3CR1 CXCR1	7.99e-05	6	81	2	28504723
Pubmed	Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling.	MTOR CX3CR1	7.99e-05	6	81	2	20933441
Pubmed	Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.	MPO GSTP1	7.99e-05	6	81	2	20091863
Pubmed	Layer V cortical neurons require microglial support for survival during postnatal development.	GDNF CX3CR1 CXCR1	8.93e-05	37	81	3	23525041
Pubmed	Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum.	MPO GSTP1	1.12e-04	7	81	2	11956078
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS15 ADAMTS13	1.12e-04	7	81	2	11867212
Pubmed	Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.	MPO GSTP1	1.12e-04	7	81	2	17885617
Pubmed	Identification of a cullin homology region in a subunit of the anaphase-promoting complex.	CDC27 ANAPC4	1.12e-04	7	81	2	9469815
Pubmed	The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.	CDC27 ANAPC4	1.12e-04	7	81	2	25383541
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	LEMD2 TUBGCP4 CDC27 ANAPC4	1.22e-04	108	81	4	19531213
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	BRIX1 USP6 ELP1 TUBGCP4 CDC27 ANAPC4	1.27e-04	331	81	6	19490893
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BRIX1 GSTP1 PDS5B DDX31 MTOR ELP1 HEATR1 THOC2	1.43e-04	653	81	8	22586326
Pubmed	Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway.	MPO GSTP1	1.49e-04	8	81	2	15829318
Pubmed	LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.	CDC27 ANAPC4	1.49e-04	8	81	2	25723520
Pubmed	Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.	CDC27 ANAPC4	1.49e-04	8	81	2	20686030
Pubmed	Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs.	RBL2 CX3CR1	1.49e-04	8	81	2	31239386
Pubmed	Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry.	CDC27 ANAPC4	1.49e-04	8	81	2	26960431
Pubmed	Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.	MPO GSTP1	1.49e-04	8	81	2	18642288
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	FLII MTOR ELP1 HEATR1	1.83e-04	120	81	4	27320910
Pubmed	How APC/C-Cdc20 changes its substrate specificity in mitosis.	CDC27 ANAPC4	1.91e-04	9	81	2	21336306
Pubmed	The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.	CDC27 ANAPC4	1.91e-04	9	81	2	20733055
Pubmed	Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.	CDC27 ANAPC4	1.91e-04	9	81	2	18471975
Pubmed	Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.	CCR8 CX3CR1	1.91e-04	9	81	2	22729248
Pubmed	Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.	CDC27 ANAPC4	2.38e-04	10	81	2	10500174
Pubmed	Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.	GSTP1 RASGRP1	2.38e-04	10	81	2	20670164
Pubmed	The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate.	MPO GSTP1	2.38e-04	10	81	2	20032816
Pubmed	Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.	CDC27 ANAPC4	2.38e-04	10	81	2	10318877
Pubmed	SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.	CDC27 ANAPC4	2.38e-04	10	81	2	22014574
Pubmed	TNF Counterbalances the Emergence of M2 Tumor Macrophages.	RBL2 CX3CR1	2.38e-04	10	81	2	26365184
Pubmed	Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population.	MPO GSTP1	2.38e-04	10	81	2	18784359
Pubmed	Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint.	CDC27 ANAPC4	2.38e-04	10	81	2	24464857
Pubmed	Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.	CDC27 ANAPC4	2.38e-04	10	81	2	25673878
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	BRIX1 GSTP1 PDS5B ZZEF1 ARHGAP45	2.86e-04	247	81	5	32989298
Pubmed	The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis.	CDC27 ANAPC4	2.91e-04	11	81	2	28404789
Pubmed	Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.	LATS2 MTOR	2.91e-04	11	81	2	29849151
Pubmed	Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.	CDC27 ANAPC4	2.91e-04	11	81	2	21241890
Pubmed	Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study.	MPO GSTP1	2.91e-04	11	81	2	18447907
Pubmed	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.	FSTL4 CLEC16A ANAPC4	3.42e-04	58	81	3	17554300
Pubmed	APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.	CDC27 ANAPC4	3.48e-04	12	81	2	21926987
Pubmed	Mitotic regulation of the human anaphase-promoting complex by phosphorylation.	CDC27 ANAPC4	3.48e-04	12	81	2	14657031
Pubmed	Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation.	CDC27 ANAPC4	3.48e-04	12	81	2	23007648
Pubmed	Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.	CDC27 ANAPC4	3.48e-04	12	81	2	26986935
Pubmed	Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.	CDC27 ANAPC4	3.48e-04	12	81	2	16364912
Pubmed	Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.	MPO GSTP1 FANCG	3.60e-04	59	81	3	19339270
Pubmed	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.	CDC27 ANAPC4	4.11e-04	13	81	2	23979597
Pubmed	Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.	CDC27 ANAPC4	4.11e-04	13	81	2	16921029
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D PEX12 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.08e-17	149	81	12	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H PEX12 TBC1D3C TBC1D3B TBC1D3F	2.46e-08	99	81	6	17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr5p13	BRIX1 GOLPH3 UGT3A2 GDNF	1.12e-04	139	81	4	chr5p13
Cytoband	5p13.2	BRIX1 UGT3A2	1.38e-03	31	81	2	5p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	LRSAM1 RABGAP1 NR6A1	1.91e-03	138	81	3	chr9q33
Cytoband	9q33.3	LRSAM1 NR6A1	1.97e-03	37	81	2	9q33.3
GeneFamily	EF-hand domain containing	RASGRP1 RASGRP4 CGREF1 RASGRP3 FSTL4 ZZEF1 PLS1	2.23e-06	219	50	7	863
GeneFamily	Anaphase promoting complex \|Tetratricopeptide repeat domain containing	CDC27 ANAPC4	6.68e-04	14	50	2	402
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS15 ADAMTS13	1.24e-03	19	50	2	50
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D UGT3A2 NR6A1 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	4.02e-14	90	81	11	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.21e-07	213	81	9	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.21e-07	213	81	9	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.57e-07	242	81	9	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.24e-06	281	81	9	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.24e-06	281	81	9	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.61e-06	320	81	9	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FANCG RBL2 LRSAM1 PLS1 CX3CR1	1.39e-05	168	81	5	94cded2e953c0970bf2f3dbe0ce46bd77a5ed8c7
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACTR5 RBL2 GUCY2D OSBP2 ARHGAP45	1.65e-05	174	81	5	ccc79febfcf588d8294ffc712338be96de8a5033
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 ELP1 PCNX1 ARHGAP45 CX3CR1	1.79e-05	177	81	5	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 ELP1 PCNX1 ARHGAP45 CX3CR1	1.79e-05	177	81	5	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	SYNE1 ELP1 PCNX1 ARHGAP45 CX3CR1	1.79e-05	177	81	5	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 ELP1 PCNX1 ARHGAP45 CX3CR1	1.79e-05	177	81	5	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 ELP1 PCNX1 ARHGAP45 CX3CR1	1.79e-05	177	81	5	d5aeda113afaa2425874394610344570c9078478
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	SYNE1 ELP1 PCNX1 ARHGAP45 CX3CR1	2.10e-05	183	81	5	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	RASGRP1 RBL2 SYNE1 PCNX1 CX3CR1	2.85e-05	195	81	5	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RASGRP1 RBL2 SYNE1 PCNX1 CX3CR1	2.92e-05	196	81	5	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RASGRP1 RBL2 SYNE1 PCNX1 CX3CR1	2.92e-05	196	81	5	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RASGRP1 RBL2 SYNE1 PCNX1 CX3CR1	2.92e-05	196	81	5	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RASGRP1 RBL2 SYNE1 PCNX1 CX3CR1	2.92e-05	196	81	5	c35f2349dfe35baa845f790b9f31673dceac54c0
Disease	Colorectal Carcinoma	MPO FANCG RELCH SYNE1 ADAMTS15 GRIK3 UGT3A2 ANAPC4	3.09e-04	702	72	8	C0009402
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 LEMD2	3.81e-04	12	72	2	DOID:11726 (implicated_via_orthology)
Disease	Libman-Sacks Disease	RASGRP1 RASGRP3 CLEC16A	3.90e-04	58	72	3	C0242380
Disease	asthma (is_implicated_in)	MPO GSTP1 ELP1 CX3CR1	5.99e-04	157	72	4	DOID:2841 (is_implicated_in)
Disease	–	CX3CR1 CXCR1	6.89e-04	16	72	2	609423
Disease	Susceptibility to HIV infection	CX3CR1 CXCR1	6.89e-04	16	72	2	cv:C1836230
Disease	pancreatic ductal carcinoma (is_implicated_in)	GSTP1 HEATR1	6.89e-04	16	72	2	DOID:3587 (is_implicated_in)
Disease	Lupus Erythematosus, Systemic	RASGRP1 RASGRP3 CLEC16A	7.07e-04	71	72	3	C0024141
Disease	cystitis (biomarker_via_orthology)	MPO CX3CR1	8.76e-04	18	72	2	DOID:1679 (biomarker_via_orthology)
Disease	CCL4 measurement	TBC1D3 TBC1D3F	1.08e-03	20	72	2	EFO_0004751
Disease	Retinal Degeneration	GDNF CX3CR1	1.20e-03	21	72	2	C0035304
Disease	status epilepticus (implicated_via_orthology)	MTOR CX3CR1	1.20e-03	21	72	2	DOID:1824 (implicated_via_orthology)
Disease	lung disease (is_implicated_in)	MPO GSTP1	1.31e-03	22	72	2	DOID:850 (is_implicated_in)
Disease	xanthosine measurement	TFCP2L1 RASGRP3	1.70e-03	25	72	2	EFO_0010549
Disease	Deafness	PCDH15 PLS1	1.70e-03	25	72	2	C0011053
Disease	serum non-albumin protein measurement	RASGRP1 RASGRP3 GUCY2D UGT3A2 ARHGAP45	1.91e-03	361	72	5	EFO_0004568
Disease	acute kidney failure (implicated_via_orthology)	MPO MTOR	1.98e-03	27	72	2	DOID:3021 (implicated_via_orthology)
Disease	corpus callosum central volume measurement	FANCG CLEC16A	2.13e-03	28	72	2	EFO_0010296
Disease	Parkinsonism (implicated_via_orthology)	GDNF CX3CR1	2.28e-03	29	72	2	DOID:0080855 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVDALLFIHYLAIVL	VANGL1	226	Q8TAA9
ELFTLYLLLHEREDS	ALS2CL	771	Q60I27
LDKYHSLNEELDFLV	CAGE1	691	Q8TC20
SNLHYLLFTILEDSL	ANAPC4	581	Q9UJX5
VELRLFLELLDHEYL	AFAP1	6	Q8N556
NKDLVHLLTLSLDLY	RASGRP1	406	O95267
AFDELPHYALLKELL	BRIX1	171	Q8TDN6
TDIYLLNLALSDLLF	CX3CR1	66	P49238
AELVLLDHGLYQFLE	ADCK5	376	Q3MIX3
LELQELLLDYSFQHL	ACTR5	106	Q9H9F9
EHLSREQVLLYLFAL	CGREF1	66	Q99674
HADLVLYITRFDLEL	ADAMTS13	171	Q76LX8
ADLEHYLLTLLATAA	ADAMTS15	236	Q8TE58
FNELFLITILDHLYS	MTMR1	521	Q13613
EEKELYLNLALHLAS	PDS5B	51	Q9NTI5
LSEHVFDLILELYNI	PDS5B	251	Q9NTI5
FDLILELYNIDSHLL	PDS5B	256	Q9NTI5
DLVNSYHLLLCALDL	RBL2	221	Q08999
IPDLYNHFLDISLEA	RABGAP1	706	Q9Y3P9
YLLTALELHTELLES	RELCH	106	Q9P260
SILIFRDEIDLHALY	PRUNE1	81	Q86TP1
LFINLTDLLYLDLSE	FLII	146	Q13045
LLSIYSLALEQDLEF	ARHGAP45	336	Q92619
ELRHENVALYLGLFL	GUCY2D	586	Q02846
HLARFYIAELTLAIE	LATS2	766	Q9NRM7
KAALLELLHELYNFL	LEMD2	266	Q8NC56
ALLEELSAEHYLPIF	LRSAM1	576	Q6UWE0
FILASDYLNALVHLI	PCNX1	1586	Q96RV3
HLYSDLADALVIFQL	PLS1	416	Q14651
ADYLHVALDLLERKL	MPO	116	P05164
FSEELNKLLLQLYLD	COMMD2	91	Q86X83
YLLILHDLDLTKSLE	DCAF10	321	Q5QP82
SLIQLFDEYELELLL	HACE1	771	Q8IYU2
LHLLTLSLDLFYTED	RASGRP4	406	Q8TDF6
DDLSFLDDNLVYHIL	GDNF	186	P39905
DDDNLLPLLHLTIEY	TUBGCP4	406	Q9UGJ1
LLHLVDVNELYDHSL	ELP1	881	O95163
HYLDLLALLLDSSEP	FANCG	366	O15287
ELVEFHYSLFLQTLL	DDX31	521	Q9H8H2
SLYLETLHALEDLLT	MROH1	891	Q8NDA8
LQRLTEDLEYHHLLD	OSBP2	551	Q969R2
EVGLALRHLLFLLEY	MED16	466	Q9Y2X0
HLYEELGDSSILFLL	PCDH15	1446	Q96QU1
LRELALNYHLLSDEL	FBXL3	226	Q9UKT7
LNYHLLSDELLLALS	FBXL3	231	Q9UKT7
DVYLLNLALSDLLFV	CCR8	71	P51685
IYAALHTEPDLLFLE	FSTL4	751	Q6MZW2
VYLLNLALADLLFAL	CXCR1	76	P25024
LLALIYLAHASDVLE	GOLPH3	236	Q9H4A6
FADYNLLDLLLIHEV	GSTP1	151	P09211
LYLLFSEDDLLSLED	MAN1C1	591	Q9NR34
NLDHLLASLLFEEYI	HEATR1	391	Q9H583
HFIFTTLDLYALDLE	GRIK3	256	Q13003
LFLLYNLGSVEALHE	SAC3D1	231	A6NKF1
LYAEVHSEEALFLLA	CDC27	31	P30260
QLFGANLDDYLHLLL	MTOR	1101	P42345
RNDDFIELDYTILLH	LXN	171	Q9BS40
ASDTHILLLEGFLLY	NMRK2	91	Q9NPI5
YSLIHQLLSAEDLEP	NR6A1	251	Q15406
YADLIQERQLFLHLL	RTTN	36	Q86VV8
RAFELLELAAVHLYL	SPATA2L	76	Q8IUW3
ELLTLLEYHDTFVLE	SYNE1	5246	Q8NF91
LINLLTLSLDLYHTE	RASGRP3	356	Q8IV61
LYQDLSLLHANELLL	SLC3A1	551	Q07837
SHIAALFLLYLPEED	TBC1D3L	191	B9A6J9
YHAIFLEELTTLELI	TFCP2L1	401	Q9NZI6
EIFTLLDLLLQQHYL	PEX12	61	O00623
LLESLDVYELFLHFS	CHPF	701	Q8IZ52
LHYLNDILIINCEFL	CLEC16A	261	Q2KHT3
SHIAALFLLYLPEED	TBC1D3B	191	A6NDS4
SHIAALFLLYLPEED	TBC1D3H	191	P0C7X1
AVLLQFNLIDLDDLY	THOC2	271	Q8NI27
FNLIDLDDLYVHLLP	THOC2	276	Q8NI27
SHIAALFLLYLPEED	TBC1D3F	191	A6NER0
SHIAALFLLYLPEED	TBC1D3E	191	A0A087X179
LQDYLLALTTDDHLL	ZZEF1	2916	O43149
SHIAALFLLYLPEED	TBC1D3D	191	A0A087WVF3
HEQYLLDVFVFLLGL	UGT3A2	481	Q3SY77
SHIAALFLLYLPEED	TBC1D3G	191	Q6DHY5
SHIAALFLLYLPEED	TBC1D3	191	Q8IZP1
SHIAALFLLYLPEED	TBC1D3K	191	A0A087X1G2
HITALFLLYLPEEDA	USP6	191	P35125
SHIAALFLLYLPEED	TBC1D3I	191	A0A087WXS9
SHIAALFLLYLPEED	TBC1D3C	191	Q6IPX1
DLYRLADLFNLTLLE	KLHL32	146	Q96NJ5