Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	HCN2 HCN4 HCN3	8.19e-07	10	39	3	GO:0005222
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN2 HCN4 HCN3	1.94e-06	13	39	3	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN2 HCN4 HCN3	1.94e-06	13	39	3	GO:0043855
GeneOntologyMolecularFunction	cAMP binding	HCN2 HCN4 HCN3	1.54e-05	25	39	3	GO:0030552
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	HCN2 HCN4 HCN3	1.74e-05	26	39	3	GO:0005248
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN2 HCN4 HCN3	3.61e-05	33	39	3	GO:0005217
GeneOntologyMolecularFunction	cyclic nucleotide binding	HCN2 HCN4 HCN3	6.00e-05	39	39	3	GO:0030551
GeneOntologyMolecularFunction	sodium channel activity	HCN2 HCN4 HCN3	1.42e-04	52	39	3	GO:0005272
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	1.66e-04	10	39	2	GO:0001849
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	HCN2 HCN4 HCN3	1.03e-03	102	39	3	GO:0005249
GeneOntologyMolecularFunction	opsonin binding	C4A C4B	1.08e-03	25	39	2	GO:0001846
GeneOntologyMolecularFunction	transaminase activity	ACCS OAT	1.17e-03	26	39	2	GO:0008483
GeneOntologyMolecularFunction	transferase activity, transferring nitrogenous groups	ACCS OAT	1.36e-03	28	39	2	GO:0016769
GeneOntologyMolecularFunction	complement binding	C4A C4B	1.78e-03	32	39	2	GO:0001848
GeneOntologyMolecularFunction	potassium channel activity	HCN2 HCN4 HCN3	1.99e-03	128	39	3	GO:0005267
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	HCN2 HCN4 HCN3	2.56e-03	140	39	3	GO:0099094
GeneOntologyMolecularFunction	carbohydrate binding	C4A C4B H6PD GALNT3	3.05e-03	310	39	4	GO:0030246
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase binding	MET CD2AP	3.19e-03	43	39	2	GO:0043548
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	HCN2 HCN4 HCN3	3.23e-03	152	39	3	GO:0022843
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	HCN2 HCN4 HCN3	4.21e-03	167	39	3	GO:0015079
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	HCN2 HCN4 HCN3	4.50e-03	171	39	3	GO:0015081
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	C4A C4B PRNP	5.19e-03	180	39	3	GO:0004866
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	HCN2 HCN4 HCN3	5.35e-03	182	39	3	GO:0005244
GeneOntologyMolecularFunction	pyridoxal phosphate binding	ACCS OAT	5.36e-03	56	39	2	GO:0030170
GeneOntologyMolecularFunction	voltage-gated channel activity	HCN2 HCN4 HCN3	5.51e-03	184	39	3	GO:0022832
GeneOntologyMolecularFunction	vitamin B6 binding	ACCS OAT	5.54e-03	57	39	2	GO:0070279
GeneOntologyMolecularFunction	peptidase inhibitor activity	C4A C4B PRNP	5.77e-03	187	39	3	GO:0030414
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	HCN2 HCN4 HCN3	6.29e-03	193	39	3	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	HCN2 HCN4 HCN3	6.66e-03	197	39	3	GO:0022834
GeneOntologyMolecularFunction	endopeptidase regulator activity	C4A C4B PRNP	7.04e-03	201	39	3	GO:0061135
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	MET EPHB1	7.15e-03	65	39	2	GO:0004714
GeneOntologyBiologicalProcess	immunological synapse formation	NEDD9 DOCK8 CD2AP EPHB1	4.60e-08	19	40	4	GO:0001771
GeneOntologyBiologicalProcess	negative regulation of cholangiocyte proliferation	LIMS1 LIMS2	1.10e-05	3	40	2	GO:1904055
GeneOntologyBiologicalProcess	cell-cell recognition	NEDD9 DOCK8 CD2AP EPHB1	3.00e-05	92	40	4	GO:0009988
GeneOntologyBiologicalProcess	cell recognition	NEDD9 C4B DOCK8 CD2AP EPHB1	3.88e-05	198	40	5	GO:0008037
GeneOntologyBiologicalProcess	cellular response to cGMP	HCN2 HCN4	7.65e-05	7	40	2	GO:0071321
GeneOntologyBiologicalProcess	potassium ion transmembrane transport	HCN2 HCN4 WNK4 PRNP HCN3	8.23e-05	232	40	5	GO:0071805
GeneOntologyBiologicalProcess	positive regulation of substrate adhesion-dependent cell spreading	NEDD9 LIMS1 LIMS2	9.68e-05	46	40	3	GO:1900026
GeneOntologyBiologicalProcess	regulation of cholangiocyte proliferation	LIMS1 LIMS2	1.02e-04	8	40	2	GO:1904054
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	1.02e-04	8	40	2	GO:2000427
GeneOntologyBiologicalProcess	response to cGMP	HCN2 HCN4	1.31e-04	9	40	2	GO:0070305
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	HCN2 HCN4 WNK4	1.32e-04	51	40	3	GO:1990573
GeneOntologyBiologicalProcess	cellular response to cAMP	HCN2 HCN4 HCN3	1.48e-04	53	40	3	GO:0071320
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	HCN2 HCN4 WNK4 PRNP	1.62e-04	142	40	4	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	HCN2 HCN4 WNK4 PRNP	1.62e-04	142	40	4	GO:0098659
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	1.63e-04	10	40	2	GO:2000425
GeneOntologyBiologicalProcess	cholangiocyte proliferation	LIMS1 LIMS2	1.63e-04	10	40	2	GO:1990705
GeneOntologyBiologicalProcess	import into cell	TUSC2 MET C4A C4B HCN2 HCN4 WNK4 PRNP CD2AP	1.72e-04	1074	40	9	GO:0098657
GeneOntologyBiologicalProcess	potassium ion transport	HCN2 HCN4 WNK4 PRNP HCN3	1.73e-04	272	40	5	GO:0006813
GeneOntologyBiologicalProcess	regulation of membrane depolarization	HCN2 HCN4 HCN3	2.25e-04	61	40	3	GO:0003254
GeneOntologyBiologicalProcess	negative regulation of transforming growth factor beta production	MET CD2AP	2.39e-04	12	40	2	GO:0071635
GeneOntologyBiologicalProcess	regulation of substrate adhesion-dependent cell spreading	NEDD9 LIMS1 LIMS2	2.84e-04	66	40	3	GO:1900024
GeneOntologyBiologicalProcess	positive regulation of integrin-mediated signaling pathway	LIMS1 LIMS2	3.29e-04	14	40	2	GO:2001046
GeneOntologyBiologicalProcess	cell junction organization	NEDD9 WHRN NBEA LIMS1 PRNP CD2AP EPHB1 LIMS2	4.80e-04	974	40	8	GO:0034330
GeneOntologyBiologicalProcess	regulation of dendritic spine maintenance	NEDD9 PRNP	5.50e-04	18	40	2	GO:1902950
GeneOntologyBiologicalProcess	liver development	MET LIMS1 CD2AP LIMS2	6.19e-04	202	40	4	GO:0001889
GeneOntologyBiologicalProcess	organelle disassembly	NEDD9 HUWE1 MAP1LC3C SNX7	6.43e-04	204	40	4	GO:1903008
GeneOntologyBiologicalProcess	hepaticobiliary system development	MET LIMS1 CD2AP LIMS2	6.54e-04	205	40	4	GO:0061008
GeneOntologyBiologicalProcess	negative regulation of hepatocyte proliferation	LIMS1 LIMS2	6.82e-04	20	40	2	GO:2000346
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	HCN2 HCN4 WNK4 HCN3	6.91e-04	208	40	4	GO:0035725
GeneOntologyBiologicalProcess	response to cAMP	HCN2 HCN4 HCN3	8.78e-04	97	40	3	GO:0051591
GeneOntologyBiologicalProcess	regulation of integrin-mediated signaling pathway	LIMS1 LIMS2	9.04e-04	23	40	2	GO:2001044
GeneOntologyBiologicalProcess	membrane depolarization during cardiac muscle cell action potential	HCN2 HCN4	9.04e-04	23	40	2	GO:0086012
GeneOntologyBiologicalProcess	cellular component maintenance	NEDD9 WHRN PRNP	9.87e-04	101	40	3	GO:0043954
GeneOntologyBiologicalProcess	import across plasma membrane	HCN2 HCN4 WNK4 PRNP	1.00e-03	230	40	4	GO:0098739
GeneOntologyBiologicalProcess	primary alcohol metabolic process	H6PD ACP3 SULT1E1	1.14e-03	106	40	3	GO:0034308
GeneOntologyBiologicalProcess	substrate adhesion-dependent cell spreading	NEDD9 LIMS1 LIMS2	1.23e-03	109	40	3	GO:0034446
GeneOntologyBiologicalProcess	sodium ion import across plasma membrane	HCN2 HCN4	1.25e-03	27	40	2	GO:0098719
GeneOntologyBiologicalProcess	negative regulation of interleukin-17 production	TUSC2 PRNP	1.25e-03	27	40	2	GO:0032700
GeneOntologyBiologicalProcess	cell-cell junction organization	WHRN LIMS1 CD2AP LIMS2	1.29e-03	246	40	4	GO:0045216
GeneOntologyBiologicalProcess	autophagy of mitochondrion	HUWE1 MAP1LC3C SNX7	1.40e-03	114	40	3	GO:0000422
GeneOntologyBiologicalProcess	dendritic spine organization	NEDD9 PRNP EPHB1	1.44e-03	115	40	3	GO:0097061
GeneOntologyCellularComponent	HCN channel complex	HCN2 HCN4 HCN3	2.80e-08	4	41	3	GO:0098855
GeneOntologyCellularComponent	dendrite	WHRN MET C4A C4B HCN2 HCN4 PRNP CD2AP HCN3 EPHB1	4.53e-06	858	41	10	GO:0030425
GeneOntologyCellularComponent	dendritic tree	WHRN MET C4A C4B HCN2 HCN4 PRNP CD2AP HCN3 EPHB1	4.63e-06	860	41	10	GO:0097447
GeneOntologyCellularComponent	axon	WHRN C4A C4B HCN2 HCN4 PRNP CD2AP HCN3 EPHB1	4.57e-05	891	41	9	GO:0030424
GeneOntologyCellularComponent	somatodendritic compartment	WHRN MET C4A C4B HCN2 HCN4 PRNP CD2AP HCN3 EPHB1	9.92e-05	1228	41	10	GO:0036477
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	1.04e-04	8	41	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	1.34e-04	9	41	2	GO:0044217
GeneOntologyCellularComponent	cell body	WHRN MET C4A C4B HCN2 HCN4 WNK4 HCN3	3.82e-04	929	41	8	GO:0044297
GeneOntologyCellularComponent	voltage-gated potassium channel complex	HCN2 HCN4 HCN3	7.55e-04	91	41	3	GO:0008076
GeneOntologyCellularComponent	neuronal cell body	WHRN MET C4A C4B HCN2 HCN4 HCN3	1.09e-03	835	41	7	GO:0043025
GeneOntologyCellularComponent	potassium channel complex	HCN2 HCN4 HCN3	1.11e-03	104	41	3	GO:0034705
GeneOntologyCellularComponent	distal axon	WHRN HCN4 PRNP CD2AP HCN3	1.54e-03	435	41	5	GO:0150034
GeneOntologyCellularComponent	cell leading edge	PSD3 NEDD9 HCN2 DOCK8 CD2AP	2.83e-03	500	41	5	GO:0031252
HumanPheno	EEG with constitutional variants	GALC PRNP	1.18e-05	2	18	2	HP:0011176
HumanPheno	EEG with persistent abnormal rhythmic activity	GALC PRNP	1.18e-05	2	18	2	HP:0010846
MousePheno	decreased spleen germinal center size	C4A C4B DOCK8	1.79e-05	22	33	3	MP:0008484
MousePheno	abnormal kidney physiology	TUSC2 MET C4A C4B GALC GALNT3 CD2AP	2.10e-05	372	33	7	MP:0002136
MousePheno	abnormal renal/urinary system physiology	TUSC2 MET OAT C4A C4B GALC GALNT3 WNK4 CD2AP	2.32e-05	695	33	9	MP:0005502
MousePheno	cortical renal glomerulopathies	TUSC2 MET C4A C4B CD2AP	2.99e-05	156	33	5	MP:0000523
MousePheno	kidney inflammation	TUSC2 MET C4A C4B CD2AP	4.65e-05	171	33	5	MP:0001859
MousePheno	renal/urinary system inflammation	TUSC2 MET C4A C4B CD2AP	5.93e-05	180	33	5	MP:0011762
MousePheno	glomerulonephritis	TUSC2 MET C4A C4B	7.04e-05	95	33	4	MP:0002743
Domain	Ion_trans_N	HCN2 HCN4 HCN3	3.63e-08	4	40	3	PF08412
Domain	Ion_trans_N	HCN2 HCN4 HCN3	3.63e-08	4	40	3	IPR013621
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN2 HCN4 HCN3	3.26e-06	14	40	3	IPR003938
Domain	PINCH	LIMS1 LIMS2	1.34e-05	3	40	2	IPR017351
Domain	CNMP_BINDING_1	HCN2 HCN4 HCN3	4.32e-05	32	40	3	PS00888
Domain	CNMP_BINDING_2	HCN2 HCN4 HCN3	4.32e-05	32	40	3	PS00889
Domain	Anaphylatoxin_comp_syst	C4A C4B	4.45e-05	5	40	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	4.45e-05	5	40	2	IPR001840
Domain	cNMP	HCN2 HCN4 HCN3	5.20e-05	34	40	3	SM00100
Domain	cNMP_binding	HCN2 HCN4 HCN3	5.20e-05	34	40	3	PF00027
Domain	cNMP-bd_dom	HCN2 HCN4 HCN3	5.68e-05	35	40	3	IPR000595
Domain	CNMP_BINDING_3	HCN2 HCN4 HCN3	5.68e-05	35	40	3	PS50042
Domain	cNMP-bd-like	HCN2 HCN4 HCN3	7.29e-05	38	40	3	IPR018490
Domain	ANATO	C4A C4B	9.33e-05	7	40	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	9.33e-05	7	40	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	9.33e-05	7	40	2	PS01177
Domain	ANATO	C4A C4B	9.33e-05	7	40	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	9.33e-05	7	40	2	IPR000020
Domain	MacrogloblnA2_CS	C4A C4B	1.24e-04	8	40	2	IPR019742
Domain	Thiol-ester_cl	C4A C4B	1.24e-04	8	40	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.24e-04	8	40	2	IPR019565
Domain	-	HCN2 HCN4 HCN3	1.47e-04	48	40	3	2.60.120.10
Domain	RmlC-like_jellyroll	HCN2 HCN4 HCN3	1.76e-04	51	40	3	IPR014710
Domain	A2M_N	C4A C4B	1.99e-04	10	40	2	PF01835
Domain	A2M_N_2	C4A C4B	1.99e-04	10	40	2	PF07703
Domain	A2M_N	C4A C4B	1.99e-04	10	40	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.99e-04	10	40	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.99e-04	10	40	2	PS00477
Domain	A2M_recep	C4A C4B	1.99e-04	10	40	2	PF07677
Domain	A2M_comp	C4A C4B	1.99e-04	10	40	2	PF07678
Domain	A2M	C4A C4B	1.99e-04	10	40	2	PF00207
Domain	A2M_N_2	C4A C4B	1.99e-04	10	40	2	IPR011625
Domain	A2M_comp	C4A C4B	1.99e-04	10	40	2	IPR011626
Domain	Macroglobln_a2	C4A C4B	1.99e-04	10	40	2	IPR001599
Domain	cNMP-bd_CS	HCN2 HCN4	5.27e-04	16	40	2	IPR018488
Domain	C345C	C4A C4B	5.96e-04	17	40	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	6.70e-04	18	40	2	IPR008930
Domain	NTR	C4A C4B	7.47e-04	19	40	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	7.47e-04	19	40	2	IPR018933
Domain	Netrin_domain	C4A C4B	1.10e-03	23	40	2	IPR001134
Domain	NTR	C4A C4B	1.10e-03	23	40	2	PS50189
Domain	TIMP-like_OB-fold	C4A C4B	1.41e-03	26	40	2	IPR008993
Domain	Ion_trans_dom	HCN2 HCN4 HCN3	1.86e-03	114	40	3	IPR005821
Domain	Ion_trans	HCN2 HCN4 HCN3	1.86e-03	114	40	3	PF00520
Domain	-	ACCS OAT	2.54e-03	35	40	2	3.90.1150.10
Domain	ARM-like	NOC4L NBEA HUWE1 DOCK8	2.59e-03	270	40	4	IPR011989
Domain	PyrdxlP-dep_Trfase_major_sub2	ACCS OAT	2.69e-03	36	40	2	IPR015422
Domain	-	ACCS OAT	3.15e-03	39	40	2	3.40.640.10
Domain	PyrdxlP-dep_Trfase	ACCS OAT	3.48e-03	41	40	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	ACCS OAT	3.48e-03	41	40	2	IPR015421
Domain	ARM-type_fold	NOC4L NBEA HUWE1 DOCK8	5.82e-03	339	40	4	IPR016024
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	1.11e-04	7	33	2	MM14685
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	1.47e-04	8	33	2	M47872
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	1.47e-04	8	33	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	2.88e-04	11	33	2	M47874
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	2.88e-04	11	33	2	MM1430
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	3.46e-04	12	33	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	4.08e-04	13	33	2	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	5.47e-04	15	33	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	7.07e-04	17	33	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	7.07e-04	17	33	2	MM1369
Pathway	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	LIMS1 LIMS2	7.94e-04	18	33	2	MM15123
Pathway	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	LIMS1 LIMS2	7.94e-04	18	33	2	M840
Pathway	WP_GENES_TARGETED_BY_MIRNAS_IN_ADIPOCYTES	HCN2 HCN4	7.94e-04	18	33	2	M39405
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	9.83e-04	20	33	2	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	1.19e-03	22	33	2	M39502
Pathway	REACTOME_POTASSIUM_CHANNELS	HCN2 HCN4 HCN3	1.53e-03	98	33	3	MM14545
Pathway	REACTOME_POTASSIUM_CHANNELS	HCN2 HCN4 HCN3	1.76e-03	103	33	3	M1073
Pubmed	Functional expression of the human HCN3 channel.	HCN2 HCN4 HCN3	6.08e-09	4	41	3	16043489
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN2 HCN4 HCN3	6.08e-09	4	41	3	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN2 HCN4 HCN3	6.08e-09	4	41	3	12928435
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN2 HCN4 HCN3	6.08e-09	4	41	3	21615589
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN2 HCN4 HCN3	6.08e-09	4	41	3	20140458
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN2 HCN4 HCN3	6.08e-09	4	41	3	22748890
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN2 HCN4 HCN3	6.08e-09	4	41	3	9630217
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN2 HCN4 HCN3	1.52e-08	5	41	3	15564593
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN2 HCN4 HCN3	1.52e-08	5	41	3	34429357
Pubmed	Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.	C4A C4B PRNP	1.52e-08	5	41	3	17947689
Pubmed	Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.	HCN2 HCN4 HCN3	5.30e-08	7	41	3	27956497
Pubmed	Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.	HCN2 HCN4 HCN3	5.30e-08	7	41	3	19421833
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	HCN2 HCN4 HCN3	1.81e-07	10	41	3	16382102
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	HCN2 HCN4 HCN3	5.49e-07	14	41	3	29107716
Pubmed	Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.	HCN2 HCN4	1.36e-06	2	41	2	16806719
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.36e-06	2	41	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.36e-06	2	41	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.36e-06	2	41	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.36e-06	2	41	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.36e-06	2	41	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.36e-06	2	41	2	3696167
Pubmed	Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.	HCN2 HCN4	1.36e-06	2	41	2	12813043
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.36e-06	2	41	2	1357031
Pubmed	The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.	HCN2 HCN4	1.36e-06	2	41	2	30877792
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.36e-06	2	41	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.36e-06	2	41	2	19933335
Pubmed	Signaling via PINCH: Functions, binding partners and implications in human diseases.	LIMS1 LIMS2	1.36e-06	2	41	2	27590440
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.36e-06	2	41	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.36e-06	2	41	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.36e-06	2	41	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.36e-06	2	41	2	12207352
Pubmed	Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.	HCN2 HCN3	1.36e-06	2	41	2	18033814
Pubmed	Two pacemaker channels from human heart with profoundly different activation kinetics.	HCN2 HCN4	1.36e-06	2	41	2	10228147
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.36e-06	2	41	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.36e-06	2	41	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.36e-06	2	41	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.36e-06	2	41	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.36e-06	2	41	2	34299197
Pubmed	C-Met-Activated Mesenchymal Stem Cells Rescue Ischemic Damage via Interaction with Cellular Prion Protein.	MET PRNP	1.36e-06	2	41	2	29705776
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.36e-06	2	41	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.36e-06	2	41	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.36e-06	2	41	2	26800705
Pubmed	Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice.	LIMS1 LIMS2	1.36e-06	2	41	2	31723057
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.36e-06	2	41	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.36e-06	2	41	2	23918728
Pubmed	Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.	HCN2 HCN4	1.36e-06	2	41	2	16777944
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.36e-06	2	41	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.36e-06	2	41	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.36e-06	2	41	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.36e-06	2	41	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.36e-06	2	41	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.36e-06	2	41	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.36e-06	2	41	2	2997024
Pubmed	LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice.	LIMS1 LIMS2	1.36e-06	2	41	2	33083097
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.36e-06	2	41	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.36e-06	2	41	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.36e-06	2	41	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.36e-06	2	41	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.36e-06	2	41	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.36e-06	2	41	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.36e-06	2	41	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.36e-06	2	41	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.36e-06	2	41	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.36e-06	2	41	2	3167981
Pubmed	Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.	HCN2 HCN4	1.36e-06	2	41	2	12194012
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.36e-06	2	41	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.36e-06	2	41	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.36e-06	2	41	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.36e-06	2	41	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.36e-06	2	41	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.36e-06	2	41	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.36e-06	2	41	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.36e-06	2	41	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.36e-06	2	41	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.36e-06	2	41	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.36e-06	2	41	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.36e-06	2	41	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.36e-06	2	41	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.36e-06	2	41	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.36e-06	2	41	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.36e-06	2	41	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.36e-06	2	41	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.36e-06	2	41	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.36e-06	2	41	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.36e-06	2	41	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	1.36e-06	2	41	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	1.36e-06	2	41	2	26814708
Pubmed	HCN3 ion channels: roles in sensory neuronal excitability and pain.	HCN2 HCN3	1.36e-06	2	41	2	31290157
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	1.36e-06	2	41	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	1.36e-06	2	41	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.36e-06	2	41	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	1.36e-06	2	41	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.36e-06	2	41	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	1.36e-06	2	41	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.36e-06	2	41	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	1.36e-06	2	41	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.36e-06	2	41	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	1.36e-06	2	41	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	1.36e-06	2	41	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	1.36e-06	2	41	2	2993295
Interaction	HCN4 interactions	HCN2 HCN4 HCN3	6.03e-07	9	40	3	int:HCN4
Interaction	HCN3 interactions	HCN4 PRNP HCN3	1.18e-06	11	40	3	int:HCN3
GeneFamily	Cyclic nucleotide gated channels	HCN2 HCN4 HCN3	2.45e-07	10	24	3	250
GeneFamily	LIM zinc finger domain containing\|LIM domain containing	LIMS1 LIMS2	1.01e-05	4	24	2	1163
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	6.05e-05	9	24	2	1234
GeneFamily	Zinc fingers CCCH-type	ZC3H12B ZC3H4	9.78e-04	35	24	2	73
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	1.03e-03	36	24	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	1.09e-03	37	24	2	454
GeneFamily	Actins\|Deafness associated genes	WHRN MET	9.77e-03	113	24	2	1152
Coexpression	GSE9037_WT_VS_IRAK4_KO_BMDM_UP	NBEA CHD3 CCDC122 CD2AP ACP3	1.47e-05	200	41	5	M5812
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5	PSD3 NEDD9 WHRN OAT NBEA CHD3 PRNP ACP3 EPHB1	8.52e-06	732	41	9	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K5
CoexpressionAtlas	kidney_adult_Podocyte_MafB_top-relative-expression-ranked_1000	PSD3 NEDD9 AS3MT GALC ABCA9 PRNP CD2AP ACP3 EPHB1	2.50e-05	838	41	9	gudmap_kidney_adult_Podocyte_MafB_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_2500_k-means-cluster#2	PSD3 NEDD9 WHRN NBEA CHD3 PRNP ACP3 EPHB1	3.18e-05	659	41	8	Facebase_RNAseq_e10.5_Olfactory Pit_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#3	PSD3 WHRN CHD3 PRNP ACP3 EPHB1	4.45e-05	339	41	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K3
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#3_top-relative-expression-ranked_500	MET GALC GALNT3	5.82e-05	39	41	3	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_500_k3
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#5	PSD3 NEDD9 WHRN NBEA CHD3 PRNP ACP3 EPHB1	6.07e-05	722	41	8	Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K5
CoexpressionAtlas	kidney_adult_RenCorpuscGlomer_k-means-cluster#2_top-relative-expression-ranked_1000	PSD3 GALC ABCA9 CD2AP ACP3	7.32e-05	227	41	5	gudmap_kidney_adult_RenCorpuscGlomer_k2_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	PSD3 NEDD9 WHRN NBEA CHD3 PRNP ACP3 EPHB1	7.43e-05	743	41	8	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#2	PSD3 NEDD9 WHRN NBEA CHD3 PRNP ACP3 EPHB1	7.71e-05	747	41	8	Facebase_RNAseq_e9.5_Maxillary Arch_2500_K2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#5_top-relative-expression-ranked_1000	MET GALC GALNT3 DOCK8 ACP3	1.95e-04	280	41	5	gudmap_developingLowerUrinaryTract_e15.5_Urothelium_1000_k5
CoexpressionAtlas	kidney_adult_Podocyte_MafB_top-relative-expression-ranked_500	PSD3 NEDD9 GALC ABCA9 CD2AP ACP3	1.98e-04	445	41	6	gudmap_kidney_adult_Podocyte_MafB_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#3	PSD3 WHRN CHD3 PRNP ACP3 EPHB1	2.03e-04	447	41	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K3
CoexpressionAtlas	Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4	OAT C4A C4B H6PD ABCA9 PRNP	2.23e-04	455	41	6	GSM777055_500
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5	PSD3 NEDD9 WHRN CHD3 PRNP ACP3 EPHB1	2.39e-04	658	41	7	Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#3_top-relative-expression-ranked_1000	MET GALC GALNT3	2.45e-04	63	41	3	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k3
CoexpressionAtlas	Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5	OAT C4A C4B H6PD ABCA9 PRNP	2.54e-04	466	41	6	GSM777050_500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_2500_k-means-cluster#4	PSD3 NEDD9 WHRN CHD3 PRNP ACP3 EPHB1	2.99e-04	683	41	7	Facebase_RNAseq_e9.5_Olfactory Placode_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#5	PSD3 NEDD9 WHRN CHD3 PRNP ACP3 EPHB1	3.13e-04	688	41	7	Facebase_RNAseq_e10.5_Mandibular Arch_2500_K5
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4	PSD3 NEDD9 WHRN CHD3 PRNP ACP3 EPHB1	4.15e-04	721	41	7	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#3	PSD3 NEDD9 WHRN CHD3 PRNP ACP3 EPHB1	4.47e-04	730	41	7	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K3
CoexpressionAtlas	DevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_1000	C4A CCDC122 DOCK8 ABCA9 ACP3 SULT1E1 LIMS2	4.62e-04	734	41	7	gudmap_developingLowerUrinaryTract_adult_bladder_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#2	PSD3 NEDD9 WHRN CHD3 PRNP ACP3 EPHB1	5.13e-04	747	41	7	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#5_top-relative-expression-ranked_500	GALC GALNT3 DOCK8	5.32e-04	82	41	3	gudmap_developingLowerUrinaryTract_e15.5_Urothelium_500_k5
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000	MET GALC HUWE1 GALNT3 DOCK8 WNK4 CD2AP	6.34e-04	774	41	7	gudmap_developingKidney_e15.5_cortic collect duct_1000
ToppCell	droplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACCS C4A TPBGL ABCA9	1.44e-05	161	41	4	f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
ToppCell	droplet-Lung-nan-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACCS C4A TPBGL ABCA9	1.44e-05	161	41	4	110cc7122e3c9f105a11d811d77c8a8852b9de6c
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C4A C4B TPBGL H6PD	1.71e-05	168	41	4	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PSD3 WNK4 PRNP ACP3	1.87e-05	172	41	4	415d57aa6278b8c12e7a2cf9c3fa5283389fb9b0
ToppCell	Epithelial-Epithelial-C_(AT2)\|Epithelial / shred on cell class and cell subclass (v4)	OAT H6PD SNX7 PRNP	1.91e-05	173	41	4	f57cbf5bd2a9e5db47b4919e9cd5e50781c1a990
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET OAT SNX7 PRNP	2.59e-05	187	41	4	6ab51e17a7782c2ae6394cad813dc3a2cde70c89
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET OAT SNX7 PRNP	2.59e-05	187	41	4	e176b5b051690f840f3b12c8f7c4cc10cbe2bbae
ToppCell	facs-GAT-Fat-24m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B H6PD PRNP SULT1E1	2.76e-05	190	41	4	3720e64129f3f3268b1dc14031a76f41c38241c2
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B H6PD PRNP SULT1E1	2.76e-05	190	41	4	73a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B H6PD PRNP SULT1E1	2.76e-05	190	41	4	b55cf1fb586b724295b7b038483249847bb344fc
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PSD3 WHRN MET ACP3	3.06e-05	195	41	4	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PSD3 WHRN MET ACP3	3.06e-05	195	41	4	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	droplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Scara5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B PRNP SULT1E1 LIMS2	3.24e-05	198	41	4	d4f74320ea6c1a7e568ee5bc48bb66cb45e1004d
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	C4A C4B ABCA9 WNK4	3.24e-05	198	41	4	7a0c4dbc8c99968d42af00a718f4fedc544599ec
Drug	HCNs	HCN2 HCN4 HCN3	6.05e-06	20	41	3	CID006857665
Drug	zatebradine	HCN2 HCN4	9.48e-06	3	41	2	ctd:C043636
Drug	2-aminothiophenol	C4A C4B	9.48e-06	3	41	2	ctd:C005464
Drug	Benoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A	PSD3 NEDD9 MET GALC PRNP	2.25e-05	190	41	5	4115_DN
Drug	Suprofen [40828-46-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A	WHRN GALNT3 HCN4 ACP3 EPHB1	2.55e-05	195	41	5	4123_UP
Drug	Hydroxyzine dihydrochloride [2192-20-3]; Up 200; 9uM; MCF7; HT_HG-U133A	NEDD9 MET H6PD ACP3 LIMS2	2.75e-05	198	41	5	5006_UP
Disease	renal cell carcinoma (is_implicated_in)	MET C4A C4B	1.14e-04	69	40	3	DOID:4450 (is_implicated_in)
Disease	immature platelet fraction	PSD3 DOCK8 CD2AP	5.00e-04	114	40	3	EFO_0009187
Disease	Liver Cirrhosis, Experimental	OAT NBEA GALC SNX7 PRNP SULT1E1	5.73e-04	774	40	6	C0023893
Disease	CCL2 measurement	WHRN LIMS1 ZC3H4	6.69e-04	126	40	3	EFO_0004749
Disease	Child Development Disorders, Specific	AS3MT DOCK8	7.11e-04	29	40	2	C0085997
Disease	Child Development Deviations	AS3MT DOCK8	7.11e-04	29	40	2	C0085996
Disease	Developmental Disabilities	AS3MT DOCK8	7.61e-04	30	40	2	C0008073
Disease	Complement deficiency disease	C4A C4B	9.21e-04	33	40	2	C0272242
Disease	Graves' disease (is_implicated_in)	C4A C4B	1.29e-03	39	40	2	DOID:12361 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HYKLYEFMFYSAREE	CABCOCO1	76	Q8IVU9
MDDYDYVHLQGKEEF	NEDD9	626	Q14511
HVEYTMEANEDYEDY	C4B	1406	P0C0L5
SAEEGYRTYHMDEYD	ACCS	76	Q96QU6
YRTYHMDEYDEDKNP	ACCS	81	Q96QU6
FFEEHMDYEYGYRSN	ABCA9	1011	Q8IUA7
MVDYIVEYDYDAVHD	CD2AP	1	Q9Y5K6
DYEIRYYEKEHNEFN	EPHB1	466	P54762
YYHRGAFFMDEDEEV	MFAP1	341	P55081
YEFEGRKYCEHDFQM	LIMS2	56	Q7Z4I7
IFEYDKRFAMYGEEF	EEF1AKMT1	101	Q8WVE0
EYYEHRYQGKMFDEE	HCN3	386	Q9P1Z3
VRYTDMESEDYHFYQ	HUWE1	4141	Q7Z6Z7
IHDYYEHRYQGKMFD	HCN4	551	Q9Y3Q4
EKGEYFVEMYYRNET	ACP3	321	P15309
TRKDYDYMLDHPEEY	DNAJC25	116	Q9H1X3
YFDEYEMKDRVTYFE	DOCK8	1871	Q8NF50
EDFEEHMIKYNAYYA	CCDC122	116	Q5T0U0
DPHYAEMEEKYYRFG	CHD3	611	Q12873
KEYFEYIGSYDEEME	GALNT3	371	Q14435
AEKYLDYHMEKYGFQ	AS3MT	111	Q9HBK9
GTFFQEEEMYRVDHY	H6PD	191	O95479
HMHYALDENYFRGYE	GALC	116	P54803
HDYYEHRYQGKMFDE	HCN2	501	Q9UL51
FREYLDYDDTRYHTM	NOC4L	171	Q9BVI4
HVEYTMEANEDYEDY	C4A	1406	P0C0L4
RDYKDEDGFVYMTYA	MAP1LC3C	106	Q9BXW4
ADFGLARDMYDKEYY	MET	1221	P08581
YEAHKEYLAKMYEEY	NBEA	951	Q8NFP9
EQEHATMAYYLDEYR	WHRN	436	Q9P202
YEFEGRKYCEHDFQM	LIMS1	51	P48059
IDYVRYMVENHGEDY	NOP16	116	Q9Y3C1
DDIFEREYKYGAHNY	OAT	41	P04181
YKEEREYFDEMKEYG	SNX7	211	Q9UNH6
DYYEKFEEVHGILMY	SULT1E1	6	P49888
MFYDEDGDLAHEFYE	TUSC2	51	O75896
FGSDYEDRYYRENMH	PRNP	141	P04156
HNREYYMAEVDRGVY	ZC3H12B	561	Q5HYM0
GMYEDYENEQYGEYE	ZC3H4	191	Q9UPT8
DQMEGYHYRYEQDAD	TPBGL	346	P0DKB5
DHYLEFEKTRYEMYV	PSD3	971	Q9NYI0
EMYEEKYDEAVDVYA	WNK4	346	Q96J92