Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionI-SMAD binding

SMAD1 SMAD5 SMAD9

4.04e-0517803GO:0070411
GeneOntologyCellularComponentheteromeric SMAD protein complex

SMAD1 SMAD5 SMAD9

2.87e-068793GO:0071144
GeneOntologyCellularComponentSMAD protein complex

SMAD1 SMAD5 SMAD9

6.12e-0610793GO:0071141
GeneOntologyCellularComponentcondensin complex

SMC2 NCAPH

3.89e-048792GO:0000796
DomainDwarfin

SMAD1 SMAD5 SMAD9

3.57e-068763IPR013790
DomainDWB

SMAD1 SMAD5 SMAD9

3.57e-068763SM00524
DomainMH2

SMAD1 SMAD5 SMAD9

3.57e-068763PS51076
DomainMH1

SMAD1 SMAD5 SMAD9

3.57e-068763PS51075
Domain-

SMAD1 SMAD5 SMAD9

3.57e-0687633.90.520.10
DomainMAD_homology_MH1

SMAD1 SMAD5 SMAD9

3.57e-068763IPR013019
DomainMH2

SMAD1 SMAD5 SMAD9

3.57e-068763PF03166
DomainSMAD_dom_Dwarfin-type

SMAD1 SMAD5 SMAD9

3.57e-068763IPR001132
DomainMAD_homology1_Dwarfin-type

SMAD1 SMAD5 SMAD9

1.39e-0512763IPR003619
DomainDWA

SMAD1 SMAD5 SMAD9

1.39e-0512763SM00523
DomainMH1

SMAD1 SMAD5 SMAD9

1.39e-0512763PF03165
DomainSMAD_dom-like

SMAD1 SMAD5 SMAD9

3.49e-0516763IPR017855
Domain-

SMAD1 SMAD5 SMAD9

3.49e-05167632.60.200.10
DomainSMAD_FHA_domain

SMAD1 SMAD5 SMAD9

1.24e-0352763IPR008984
DomainMAM_1

PTPRM EGFL6

1.89e-0316762PS00740
DomainMAM

PTPRM EGFL6

2.14e-0317762SM00137
DomainMAM

PTPRM EGFL6

2.40e-0318762PF00629
DomainMAM_dom

PTPRM EGFL6

2.40e-0318762IPR000998
DomainMAM_2

PTPRM EGFL6

2.40e-0318762PS50060
Domain-

RGS5 RGS3

3.58e-03227621.10.196.10
DomainRGS_subdom1

RGS5 RGS3

3.58e-0322762IPR024066
Domainfn3

MID2 KALRN PTPRM MYBPC2

4.31e-03162764PF00041
DomainFN3

MID2 KALRN PTPRM MYBPC2

6.87e-03185764SM00060
PathwayKEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY

SMAD1 SMAD5 SMAD9

2.29e-067583M47845
PathwayKEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY

SMAD1 SMAD5 SMAD9

3.65e-068583M47847
PathwayKEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY

SMAD1 SMAD5 SMAD9

5.46e-069583M47844
PathwayKEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY

SMAD1 SMAD5 SMAD9

5.46e-069583M47822
PathwayPID_ALK2_PATHWAY

SMAD1 SMAD5 SMAD9

1.07e-0511583M203
PathwayKEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY

SMAD1 SMAD5 SMAD9

1.07e-0511583M47848
PathwayWP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION

SMAD1 SMAD5 SMAD9

1.84e-0513583M39378
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY

SMAD1 SMAD5 SMAD9

7.17e-0520583M47843
PathwayWP_DIFFERENTIATION_OF_WHITE_AND_BROWN_ADIPOCYTE

SMAD1 SMAD5 SMAD9

1.43e-0425583M39665
PathwayPID_ALK1_PATHWAY

SMAD1 SMAD5 SMAD9

1.61e-0426583M185
PathwayREACTOME_MAPK6_MAPK4_SIGNALING

CDC14C KALRN PAK2 CDC14B

2.27e-0473584MM15285
PathwayREACTOME_SIGNALING_BY_BMP

SMAD1 SMAD5 SMAD9

2.74e-0431583M1662
PathwayREACTOME_SIGNALING_BY_BMP

SMAD1 SMAD5 SMAD9

2.74e-0431583MM14789
PathwayREACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES

SMC2 NCAPH

4.58e-048582MM14895
PathwayWP_NEOVASCULARIZATION_PROCESSES

SMAD1 SMAD5 SMAD9

4.65e-0437583M39506
PathwayPID_AURORA_B_PATHWAY

EVI5 SMC2 NCAPH

5.44e-0439583M14
PathwayPID_BMP_PATHWAY

SMAD1 SMAD5 SMAD9

6.77e-0442583M181
PathwayREACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES

SMC2 NCAPH

8.93e-0411582M27182
Pubmed

Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.

SMAD1 SMAD5 SMAD9

1.17e-08380330953749
Pubmed

Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.

SMAD1 SMAD5 SMAD9

1.17e-08380321381028
Pubmed

Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.

SMAD1 SMAD5 SMAD9

1.17e-08380324023003
Pubmed

Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.

SMAD1 SMAD5 SMAD9

1.17e-08380327848974
Pubmed

Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.

SMAD1 SMAD5 SMAD9

1.17e-08380331127639
Pubmed

Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.

SMAD1 SMAD5 SMAD9

1.17e-08380322897816
Pubmed

A crucial role of a high mobility group protein HMGA2 in cardiogenesis.

SMAD1 SMAD5 SMAD9

4.68e-08480318425117
Pubmed

Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.

SMAD1 SMAD5 SMAD9

4.68e-08480323993924
Pubmed

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.

SMAD1 SMAD5 SMAD9

4.68e-08480317967875
Pubmed

Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.

SMAD1 SMAD5 SMAD9

4.68e-08480322452883
Pubmed

KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.

SMAD1 SMAD5 SMAD9

4.68e-08480325536014
Pubmed

Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.

SMAD1 SMAD5 SMAD9

4.68e-08480328401685
Pubmed

Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells.

SMAD1 SMAD5 SMAD9

4.68e-08480319244313
Pubmed

Signal transduction of bone morphogenetic protein receptors.

SMAD1 SMAD5 SMAD9

4.68e-08480314687659
Pubmed

Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.

SMAD1 SMAD5 SMAD9

4.68e-08480325755279
Pubmed

Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.

SMAD1 SMAD5 SMAD9

4.68e-08480334719843
Pubmed

Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.

SMAD1 SMAD5 SMAD9

1.17e-07580327188281
Pubmed

Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.

SMAD1 SMAD5 SMAD9

1.17e-07580338703029
Pubmed

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.

SMAD1 SMAD5 SMAD9

1.17e-07580311121043
Pubmed

Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.

SMAD1 SMAD5 SMAD9

1.17e-07580320651281
Pubmed

Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse.

SMAD1 SMAD5 SMAD9

1.17e-07580338300806
Pubmed

Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.

SMAD1 SMAD5 SMAD9

1.17e-07580325141865
Pubmed

The TGFβ pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta.

SMAD1 SMAD5 SMAD9

1.17e-07580329253505
Pubmed

Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.

SMAD1 SMAD5 SMAD9

1.17e-07580327612439
Pubmed

Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development.

SMAD1 SMAD5 SMAD9

1.17e-07580327890611
Pubmed

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.

SMAD1 SMAD5 SMAD9

1.17e-07580321246655
Pubmed

Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.

SMAD1 SMAD5 SMAD9

1.17e-07580318775991
Pubmed

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.

SMAD1 SMAD5 SMAD9

1.17e-07580326735394
Pubmed

FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts.

SMAD1 SMAD5 SMAD9

1.17e-07580323559326
Pubmed

Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.

SMAD1 SMAD5 SMAD9

1.17e-07580315743817
Pubmed

Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation.

SMAD1 SMAD5 SMAD9

1.17e-07580319918795
Pubmed

Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals.

SMAD1 SMAD5 SMAD9

1.17e-07580338175868
Pubmed

Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.

SMAD1 SMAD5 SMAD9

1.17e-07580310583507
Pubmed

The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity.

SMAD1 SMAD5 SMAD9

1.17e-07580333393086
Pubmed

Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development.

SMAD1 SMAD5 SMAD9

1.17e-07580316813523
Pubmed

Requirement of Oct3/4 function for germ cell specification.

SMAD1 SMAD5 SMAD9

1.17e-07580318395706
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TXLNA TRMT10C ZC3H11A UBE2O GNL3L VPS13C DDX52 UGGT1 ETFB EIF2S2 EHMT1 GIGYF2 CHD1 SMC2 NCAPH SDAD1

1.31e-071425801630948266
Pubmed

Single-cell transcriptomics uncovers a non-autonomous Tbx1-dependent genetic program controlling cardiac neural crest cell development.

RGS5 SMAD1 SMAD5 SMAD9

1.51e-072180436941249
Pubmed

Smad7 is required for the development and function of the heart.

SMAD1 SMAD5 SMAD9

2.33e-07680318952608
Pubmed

PDGF-AA promotes osteogenic differentiation and migration of mesenchymal stem cell by down-regulating PDGFRα and derepressing BMP-Smad1/5/8 signaling.

SMAD1 SMAD5 SMAD9

2.33e-07680325470749
Pubmed

BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst.

SMAD1 SMAD5 SMAD9

2.33e-07680320837004
Pubmed

Lack of the bone morphogenetic protein BMP6 induces massive iron overload.

SMAD1 SMAD5 SMAD9

2.33e-07680319252488
Pubmed

BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice.

SMAD1 SMAD5 SMAD9

2.33e-07680328576771
Pubmed

Development of bat flight: morphologic and molecular evolution of bat wing digits.

SMAD1 SMAD5 SMAD9

2.33e-07680316618938
Pubmed

Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development.

SMAD1 SMAD5 SMAD9

2.33e-07680320522595
Pubmed

Quantitative analysis of signaling responses during mouse primordial germ cell specification.

SMAD1 SMAD5 SMAD9

2.33e-07680334184730
Pubmed

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.

SMAD1 SMAD5 SMAD9

2.33e-07680321518886
Pubmed

Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion.

SMAD1 SMAD5 SMAD9

2.33e-07680327250101
Pubmed

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.

SMAD1 SMAD5 SMAD9

2.33e-07680320042635
Pubmed

BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors.

SMAD1 SMAD5 SMAD9

2.33e-07680333436697
Pubmed

Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.

SMAD1 SMAD5 SMAD9

2.33e-07680311850197
Pubmed

Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade.

SMAD1 SMAD5 SMAD9

2.33e-07680315188429
Pubmed

BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells.

SMAD1 SMAD5 SMAD9

2.33e-07680319269967
Pubmed

SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.

SMAD1 SMAD5 SMAD9

2.33e-07680318069690
Pubmed

The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification.

SMAD1 SMAD5 SMAD9

2.33e-07680322723422
Pubmed

BMPER-induced BMP signaling promotes coronary artery remodeling.

SMAD1 SMAD5 SMAD9

4.07e-07780324373957
Pubmed

Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.

SMAD1 SMAD5 SMAD9

4.07e-07780315009097
Pubmed

Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.

SMAD1 SMAD5 SMAD9

4.07e-07780320807528
Pubmed

Emergence of dorsal-ventral polarity in ESC-derived retinal tissue.

SMAD1 SMAD5 SMAD9

4.07e-07780327633992
Pubmed

Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis.

SMAD1 SMAD5 SMAD9

4.07e-07780319782070
Pubmed

Noggin is required for early development of murine upper incisors.

SMAD1 SMAD5 SMAD9

4.07e-07780322302143
Pubmed

Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.

SMAD1 SMAD5 SMAD9

4.07e-07780325758226
Pubmed

Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2.

SMAD1 SMAD5 SMAD9

4.07e-07780323680673
Pubmed

Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.

SMAD1 SMAD5 SMAD9

4.07e-07780319116164
Pubmed

Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.

SMAD1 SMAD5 SMAD9

4.07e-07780329151265
Pubmed

Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.

SMAD1 SMAD5 SMAD9

4.07e-07780316624858
Pubmed

HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation.

SMAD1 SMAD5 SMAD9

4.07e-07780324269886
Pubmed

Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.

SMAD1 SMAD5 SMAD9

4.07e-07780315376321
Pubmed

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.

SMAD1 SMAD5 SMAD9

4.07e-07780318322278
Pubmed

Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge.

SMAD1 SMAD5 SMAD9

4.07e-07780318003744
Pubmed

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

SMAD1 SMAD5 SMAD9

4.07e-07780311163184
Pubmed

Role of smad- and wnt-dependent pathways in embryonic cardiac development.

SMAD1 SMAD5 SMAD9

4.07e-07780316522160
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ZC3H11A KMT2D CCDC59 HDAC6 INTS12 DDX52 EIF2S2 SIM2 SMC2 NCAPH TTF1 SMAD9

6.02e-07857801225609649
Pubmed

A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.

SMAD1 SMAD5 SMAD9

6.51e-07880319211612
Pubmed

Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

SMAD1 SMAD5 SMAD9

6.51e-07880310647776
Pubmed

Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a.

SMAD1 SMAD5 SMAD9

6.51e-07880329126155
Pubmed

Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.

SMAD1 SMAD5 SMAD9

6.51e-07880329135976
Pubmed

Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth.

SMAD1 SMAD5 SMAD9

6.51e-07880328574994
Pubmed

Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.

SMAD1 SMAD5 SMAD9

6.51e-07880323804438
Pubmed

BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

SMAD1 SMAD5 SMAD9

6.51e-07880317301089
Pubmed

Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.

SMAD1 SMAD5 SMAD9

6.51e-07880323064761
Pubmed

Bmp signaling is required for development of primary lens fiber cells.

SMAD1 SMAD5 SMAD9

6.51e-07880312117821
Pubmed

Bmp7 functions via a polarity mechanism to promote cloacal septation.

SMAD1 SMAD5 SMAD9

6.51e-07880322253716
Pubmed

SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.

SMAD1 SMAD5 SMAD9

6.51e-07880330446626
Pubmed

Enhanced BMP signaling through ALK2 attenuates keratinocyte differentiation.

SMAD1 SMAD5 SMAD9

6.51e-07880336116371
Pubmed

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.

SMAD1 SMAD5 SMAD9

6.51e-07880329093060
Pubmed

TGF-beta signaling by Smad proteins.

SMAD1 SMAD5 SMAD9

6.51e-07880310708949
Pubmed

Preformed Wolffian duct regulates Müllerian duct elongation independently of canonical Wnt signaling or Lhx1 expression.

SMAD1 SMAD5 SMAD9

6.51e-07880325896202
Pubmed

Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.

SMAD1 SMAD5 SMAD9

6.51e-07880323458899
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

UBE2O GNL3L KIN CCDC174 VPS13C UGGT1 EIF2S2 OSBPL8 CHD1 PCDH17 TGS1

9.47e-07733801134672954
Pubmed

Holding their own: the noncanonical roles of Smad proteins.

SMAD1 SMAD5 SMAD9

9.75e-07980319018011
Pubmed

BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.

SMAD1 SMAD5 SMAD9

9.75e-07980328641928
Pubmed

Inhibitory SMAD6 interferes with BMP-dependent generation of muscle progenitor cells and perturbs proximodistal pattern of murine limb muscles.

SMAD1 SMAD5 SMAD9

9.75e-07980337272529
Pubmed

GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.

SMAD1 SMAD5 SMAD9

9.75e-07980324932701
Pubmed

Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche.

SMAD1 SMAD5 SMAD9

9.75e-07980330735122
Pubmed

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis.

SMAD1 SMAD5 SMAD9

9.75e-07980317522159
Pubmed

TGF-beta signal transduction.

SMAD1 SMAD5 SMAD9

9.75e-0798039759503
Pubmed

Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression.

SMAD1 SMAD5 SMAD9

9.75e-07980325514040
Pubmed

Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.

SMAD1 SMAD5 SMAD9

9.75e-07980316765933
Pubmed

Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.

SMAD1 SMAD5 SMAD9

9.75e-07980330134160
InteractionSERF2 interactions

RTF1 CCDC59 UTP11 DDX52 PAK2

2.34e-0587795int:SERF2
InteractionSNRNP70 interactions

TRMT10C ZC3H11A UBE2O CCDC59 KIN DDX52 EIF2S2 CDKL3 CDC14B SDAD1 SMAD1 SMAD5 SMAD9 TGS1

2.55e-059847914int:SNRNP70
InteractionTOB1 interactions

ATE1 SMAD1 SMAD5 SMAD9

2.64e-0544794int:TOB1
GeneFamilySMAD family

SMAD1 SMAD5 SMAD9

9.14e-078473750
GeneFamilyFibronectin type III domain containing

MID2 KALRN PTPRM MYBPC2

7.83e-04160474555
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

HDAC6 UBN1 PPP1R9A EIF2S2

1.24e-03181474694
GeneFamilyRegulators of G-protein signaling

RGS5 RGS3

1.35e-0321472720
GeneFamilyAtaxins|Trinucleotide repeat containing

KMT2D GIGYF2

1.91e-0325472775
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2D EHMT1

3.52e-0334472487
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

KALRN PTPRM MYBPC2

8.44e-03161473593
CoexpressionTABULA_MURIS_SENIS_TRACHEA_T_CELL_AGEING

RTF1 TRMT10C UTP11 UGGT1 PRR13 EHMT1 CHD1 SDAD1 APBB1IP

7.78e-06445799MM3853
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5

DDX52 GCC2 DNAH2 SIM2 SMC2 NCAPH TGS1

5.07e-06186777Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

EVI5 TRMT10C UBE2O INTS12 KIN GCC2 EIF2S2 CHD1 SMC2 NCAPH CDC14B PCDH17 SMAD5 SMAD9 TGS1

3.70e-0512527715facebase_RNAseq_e10.5_MaxArch_2500_K3
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

RTF1 EVI5 ZC3H11A VPS13C GCC2 CHD1 SMAD5 TGS1

2.70e-0919880876d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

PTPRM RGS5 SPEF2 PPP1R9A PCDH17 SMAD1 SMAD5

7.45e-082008073b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ZNF385D KALRN PTPRM RGS5 PCDH17 SMAD9

1.11e-061878062d20193a6cacdfa4877457c97b0077408942186c
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRM RGS5 SPEF2 PPP1R9A PCDH17 SMAD1

1.33e-06193806e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRM RGS5 SPEF2 PPP1R9A PCDH17 SMAD1

1.33e-061938066e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRM RGS5 SPEF2 PPP1R9A PCDH17 SMAD1

1.37e-061948060b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PTPRM SPEF2 PPP1R9A PCDH17 SMAD1 SMAD5

1.64e-06200806dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PTPRM SPEF2 PPP1R9A PCDH17 SMAD1 SMAD5

1.64e-06200806a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PTPRM RGS5 SPEF2 PPP1R9A PCDH17 SMAD1

1.64e-06200806b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_1|367C / Donor, Lineage, Cell class and subclass (all cells)

SYT2 SMC2 NCAPH CDCA5 MYBPC2

1.69e-05177805ba701d3c90722d8bff70d0fa651899305cdad257
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ZNF385D KALRN PTPRM PCDH17 SMAD9

2.09e-05185805f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

RTF1 GNL3L TRANK1 GCC2 GIGYF2

2.14e-0518680503db813598b67b1e08f759758a1c2023396921fa
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

ZNF385D KALRN RGS5 PCDH17 SMAD9

2.25e-05188805d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF385D KALRN PTPRM PCDH17 SMAD9

2.37e-05190805656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

ZNF385D KALRN PTPRM PCDH17 SMAD1

2.37e-0519080578e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ZNF385D KALRN PTPRM PCDH17 SMAD9

2.37e-051908059fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRM RGS5 SPEF2 PPP1R9A PCDH17

2.55e-05193805af5108260783e69a7d67896c5bf64f862525926d
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZNF385D KALRN PTPRM RGS5 PCDH17

2.55e-051938059ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCellIPF-Endothelial-VE_Venous|IPF / Disease state, Lineage and Cell class

ZNF385D KALRN RGS5 PCDH17 SMAD9

2.55e-0519380529a655fa80feaabe846c90a28363b037e22d24ae
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF385D KALRN PTPRM PCDH17 SMAD9

2.55e-05193805287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCellIPF-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

ZNF385D KALRN RGS5 PCDH17 SMAD9

2.55e-05193805ef66a46e7ab44fcc4005a23416e6da478a4cce37
ToppCellEndothelial|World / Lineage, Cell type, age group and donor

KALRN PTPRM RGS5 PCDH17 SMAD1

2.75e-0519680596c6d78482a130ce4e29f6629972a06d10d7530e
ToppCellwk_15-18-Hematologic_Lymphocytic-B-Large_pre-B|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SYK SMC2 NCAPH CDCA5 APBB1IP

2.82e-051978057e0834b3947031bf244a10624dcf3f2095c79368
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RTF1 KALRN SETBP1 OSBPL8 GABBR2

2.89e-051988050ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellmLN-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

PPP1R9A SYK CPXM1 NCAPH CDCA5

2.96e-05199805c81a194f8c2f120c6c4d74857912865a3c2fe1e7
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

RTF1 ZC3H11A VPS13C GCC2 OSBPL8

2.96e-0519980553ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

ZC3H11A VPS13C GCC2 OSBPL8 SMAD5

2.96e-05199805fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

RTF1 ZC3H11A VPS13C GCC2 OSBPL8

2.96e-05199805c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage-Macrophages-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF385D PTPRM RGS5 PCDH17 SMAD9

3.03e-0520080598f6a86fbbe5305c71dae91e7278de9813827935
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

PTPRM PPP1R9A PCDH17 SMAD1 SMAD5

3.03e-05200805eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Macrophages|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ZNF385D PTPRM RGS5 PCDH17 SMAD9

3.03e-05200805d7b89a721988660d8010c804916f5d0ef2520ee2
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage-Macrophages|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF385D PTPRM RGS5 PCDH17 SMAD9

3.03e-052008051ed1c673184f0c6aae04f90edbb1383b1c1f64d9
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF385D PTPRM RGS5 PCDH17 SMAD9

3.03e-052008052a1ba87ca4adf351ef8fa2b3154b86a5407b8f2f
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT1-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRMT10C RILP TSSK4 NOS1AP

9.42e-05132804c6bf0b4b9e33b517629faf4559a21d7ba720ee6a
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRANK1 KALRN PCDH17 APBB1IP

1.58e-04151804b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

KALRN RGS5 GNRHR EGFL6

1.88e-0415880484c0a215dabf697ada036c2b9592d0c61b5077de
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMC2 NCAPH CDCA5 EGFL6

2.12e-04163804466c8129852a5b16cd9fcc6b79e799abc21bb21a
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCZ1 KALRN NCAPH EGFL6

2.22e-041658040edd56e8d14eaeced9882dd9206ea93e8f402e8d
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCZ1 KALRN NCAPH EGFL6

2.22e-04165804fa3aadfff6fb1e7f142db333c60c2cba02b17e6c
ToppCelldroplet-Marrow-BM-1m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PACS2 RILP TSSK4 BAHCC1

2.38e-041688042e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

SMC2 NCAPH CDCA5 SMAD9

2.49e-0417080473601c873b177d5d134618d8e228c51381119f7d
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC6 SETBP1 PACS2 TSSK4

2.60e-041728047fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

ZNF385D TMC1 KALRN PCDH17

2.60e-04172804c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellmild-Others-CD34+_GATA2+_cells|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ZNF385D CPXM1 SYT2 BAHCC1

2.60e-04172804379f6f271e653d5e404851e51a189bd582bb0f43
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC6 SETBP1 PACS2 TSSK4

2.60e-041728042a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC2 NCAPH TSSK4 CDCA5

2.66e-04173804c399786aa25bdbe3394988db6955842b5b7e6b41
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC2 NCAPH TSSK4 CDCA5

2.66e-0417380431784679190fbd95fc23d7c66008eb21b8c7cc5d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR22 SETBP1 GIGYF2 TSSK4

2.78e-0417580465571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF385D SMC2 CDCA5 RGS3

2.78e-04175804876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SYT2 SMC2 NCAPH CDCA5

2.78e-041758046b4e841bde6cfa4956e1a0231672cea20f11210c
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC2 NCAPH CDCA5 PCDH17

2.84e-041768048385435074cc5235b7af7424974f609388fc2cff
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

ZNF385D KALRN PCDH17 SMAD9

2.90e-0417780471bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCellControl|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRM SPEF2 PPP1R9A PCDH17

2.90e-04177804b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D TMC1 PCDH17 SMAD9

2.90e-04177804fdf2af00fc971f0cd3915e1416e4a256458d6ea8
ToppCellCOVID-19-Heart-Lymph_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZNF385D KALRN SMAD1 SMAD9

2.90e-04177804326fde0734ef0d7272693966d346ca479b9d8147
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D TMC1 PCDH17 SMAD9

2.90e-0417780412f8627124acbf436e75681ff1ce429ff5e3f256
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMC2 NCAPH CDCA5 PCDH17

2.96e-04178804462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCellCOPD-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

KALRN PTPRM RGS5 PCDH17

3.03e-041798049968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCellsystemic_lupus_erythematosus-treated-Hematopoietic-progenitor_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZNF385D PPP1R9A CPXM1 PCDH17

3.09e-041808042694f5deaed551c53e74d8a9fbd41d3734bb9f37
ToppCellsystemic_lupus_erythematosus-treated-Hematopoietic-progenitor_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZNF385D PPP1R9A CPXM1 PCDH17

3.09e-04180804ef0de602fc8ccfd32a06978ac0100afe0ce1beeb
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

KALRN RGS5 PCDH17 SMAD9

3.09e-0418080427e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D SMC2 NCAPH CDCA5

3.16e-0418180473b1b59810f60e3e39ca1d5073a5a0d4f5377e6e
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

KALRN PTPRM GABBR2 PCDH17

3.16e-04181804c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell356C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

ZNF385D SMC2 NCAPH CDCA5

3.16e-04181804be4f35c9eb5b3083acb2264128f095fac1f3da45
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

DNAH2 SYK NCAPH CDCA5

3.16e-04181804ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SMC2 NCAPH CDCA5 RGS3

3.22e-04182804336cd05e46a741185ce3c59ee67a4b07fa6a5101
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_Myeloid|bone_marrow / Manually curated celltypes from each tissue

SYK CPXM1 NCAPH CDCA5

3.22e-041828046745d464c3ff289726aa8164e9a43f407f8e4380
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D GPR83 PTPRM RGS5

3.22e-04182804f00eec1f434d92d44787d3d3343476c98c3de5b4
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C GCC2 SYK CHD1

3.22e-04182804f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZNF385D KALRN PTPRM SMAD1

3.29e-04183804ff95382cfed592190d0636d2b750328471f82e0d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC2 NCAPH CDCA5 SDAD1

3.29e-041838046c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCellIIF-Lymphocyte-T_NK-T_NK_proliferative|IIF / Disease, Lineage and Cell Type

SMC2 NCAPH CDCA5 NOS1AP

3.36e-04184804ab8b45ce40e8c5f66e5c23332a591b4f9cba4ce1
ToppCellCOPD-Endothelial-VE_Venous|COPD / Disease state, Lineage and Cell class

ZNF385D KALRN RGS5 PCDH17

3.36e-0418480444d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C SMC2 APBB1IP SMAD9

3.36e-04184804e7b9c69fc77040c5191ad8089697051e2589c30e
ToppCellBac-SEP-Lymphocyte-T_NK-T_NK_proliferative|Bac-SEP / Disease, Lineage and Cell Type

CPXM1 SMC2 NCAPH CDCA5

3.36e-04184804848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMC2 NCAPH CDCA5 PCDH17

3.43e-04185804282b3de8850f3c21704339e8d8737b432a43441a
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ZNF385D KALRN SMAD1 SMAD9

3.43e-041858044a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C GCC2 SYK CHD1

3.43e-041858047adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ZNF385D KALRN SMAD1 SMAD9

3.43e-0418580436ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERCC4 PAK2 ATF4 PCDH17

3.50e-0418680439e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPH CDCA5 EGFL6 MYBPC2

3.50e-041868043993f1ef8a33b8a75dfd3db8d4845b5afbb0bb3d
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPH CDCA5 EGFL6 MYBPC2

3.50e-04186804ec6d0c29e196e374baa96dd3d506f489c959e77e
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR22 GIGYF2 SYT2 TSSK4

3.50e-04186804a1ab273b01971d6a892912560d387685dd657179
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERCC4 PAK2 ATF4 PCDH17

3.50e-0418680402418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRANK1 KALRN GABBR2 NOS1AP

3.50e-041868047278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR22 GIGYF2 SYT2 TSSK4

3.57e-04187804ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

KALRN RGS5 PCDH17 SMAD9

3.57e-04187804e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PTPRM RGS5 RGS3 PCDH17

3.64e-04188804366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D TMC1 PCDH17 SMAD9

3.64e-04188804524d1d928c9386acf20e53d31894107dd7290dc7
ToppCellCOVID-19-lung-Artery_EC|lung / Disease (COVID-19 only), tissue and cell type

PTPRM SETBP1 PCDH17 SMAD9

3.64e-04188804eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D TMC1 PCDH17 SMAD9

3.64e-041888041b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D TMC1 PCDH17 SMAD9

3.64e-04188804cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D TMC1 PCDH17 SMAD9

3.64e-04188804f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR83 SMC2 CDCA5 PCDH17

3.64e-0418880433afe31b1093d317dc38c324197c6e91bf6c39d3
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-Cycling_Dendritic|lymph-node_spleen / Manually curated celltypes from each tissue

CPXM1 SYT2 NCAPH CDCA5

3.64e-04188804723348a1836a074e068320cb736ce6a953e0038f
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC2 NCAPH TNP2 CDCA5

3.64e-0418880461ae7405ab56570409bf35382dc0a038e4137c15
ToppCell5'-Airway_Nasal-Endothelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF385D TMC1 PCDH17 SMAD9

3.64e-041888046c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCellPericytes-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

ZNF385D RGS5 CPXM1 EGFL6

3.64e-0418880414c1c88a944c66f2eaac1ce7526815dcce1f5147
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

KALRN PTPRM PCDH17 SMAD9

3.72e-04189804c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCellControl-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

KALRN RGS5 PCDH17 SMAD9

3.72e-04189804f83f7521e377ded1522639e9a35c98b3e2725bac
Drug5-methoxypsoralen

SMAD1 SMAD5 SMAD9

1.45e-067803ctd:C022909
DrugLDN 193189

SMAD1 SMAD5 SMAD9

2.31e-068803ctd:C554430
Drug1,3,2-dioxaborolan-2-ol

PAK2 GNRHR SMAD1 SMAD5 SMAD9

3.31e-05104805CID005289333
Drug(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Up 200; 11uM; HL60; HT_HG-U133A

ZNF385D TRANK1 RGS5 EHMT1 TNP2 NOS1AP

5.30e-051888063046_UP
DrugMepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A

EVI5 ERCC4 GNL3L PPP1R9A SMAD5 TGS1

5.46e-051898064304_DN
DrugPempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT_HG-U133A

ERCC4 GNL3L UBN1 PPP1R9A SIM2 SMAD5

5.62e-051908064307_DN
DrugTiabendazole [148-79-8]; Up 200; 19.8uM; MCF7; HT_HG-U133A

EVI5 ERCC4 GNL3L CDC14B GNRHR NOS1AP

5.78e-051918062840_UP
Drugimperatorin

SMAD1 SMAD5 SMAD9

6.13e-0522803ctd:C031534
DrugEtofenamate [30544-47-9]; Down 200; 10.8uM; MCF7; HT_HG-U133A

ERCC4 DDX52 CDKL3 SIM2 RGS3 TGS1

6.49e-051958067327_DN
DrugBucladesine sodium salt [16980-89-5]; Up 200; 7.8uM; HL60; HT_HG-U133A

ZNF385D KMT2D EHMT1 GABBR2 TNP2 APBB1IP

6.67e-051968062741_UP
DrugChlorogenic acid [327-97-9]; Up 200; 11.2uM; HL60; HT_HG-U133A

UBE2O ERCC4 C5 APBB1IP SMAD5 TGS1

6.67e-051968061346_UP
DrugNorgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A

EVI5 GNL3L CDKL3 SYK CDC14B RGS3

6.86e-051978063708_DN
DrugOxybenzone [131-57-7]; Up 200; 17.6uM; MCF7; HT_HG-U133A

EVI5 SETBP1 SIM2 CDC14B SMAD1 NOS1AP

7.06e-051988065410_UP
DrugThiethylperazine malate [52239-63-1]; Down 200; 6uM; MCF7; HT_HG-U133A

EVI5 GPR22 CDKL3 SYK SMAD5 NOS1AP

7.06e-051988063576_DN
DrugTetrahydroxy-1,4-quinone monohydrate [319-89-1]; Up 200; 21uM; MCF7; HT_HG-U133A

GNL3L KALRN RGS5 SYT2 CDC14B GNRHR

7.26e-051998064159_UP
DrugCefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; HL60; HT_HG-U133A

ZNF385D RGS5 GABBR2 TNP2 RGS3 APBB1IP

7.46e-052008062988_DN
DrugAtractyloside potassium salt [102130-43-8]; Up 200; 5uM; HL60; HT_HG-U133A

GPR22 UGGT1 CDKL3 SIM2 RGS3 SMAD5

7.46e-052008062573_UP
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

SMAD1 SMAD5 SMAD9

4.61e-0613763DOID:0050787 (implicated_via_orthology)
Diseasemonocyte percentage of leukocytes

EVI5 SPEF2 PRR13 ETFB APBB1IP EGFL6 NOS1AP BAHCC1 TGS1

1.08e-04731769EFO_0007989
Diseaseplatelet reactivity measurement, thrombus formation measurement

RGS5 SETBP1

1.36e-047762EFO_0004985, EFO_0007615
DiseaseIdiopathic pulmonary hypertension

SMAD1 SMAD9

2.33e-049762C0152171
Diseasemean platelet volume

TRANK1 UBN1 KALRN GCC2 SETBP1 SYK RGS3 SMAD5 NOS1AP TGS1

2.82e-0410207610EFO_0004584
Diseasecognitive function measurement

ZNF385D KMT2D ERCC4 KALRN SETBP1 CDKL3 GIGYF2 SMC2 CDC14B RGS3 PCDH17 MYBPC2

2.87e-0414347612EFO_0008354
Diseaseneutrophil percentage of granulocytes

RTF1 TRMT10C SPEF2 CHD1 APBB1IP

3.12e-04228765EFO_0007994
Diseaseeosinophil percentage of granulocytes

RTF1 TRMT10C SPEF2 CHD1 APBB1IP

3.51e-04234765EFO_0007996
Diseasebitter alcoholic beverage consumption measurement

ZNF385D ERCC4 DNAH2 BAHCC1

3.94e-04133764EFO_0010092
Disease2-oxo-hept-3-ene-1,7-dioate hydratase activity

SMAD1 SMAD9

5.84e-0414762C1150929
DiseaseIdiopathic pulmonary arterial hypertension

SMAD1 SMAD9

7.67e-0416762C3203102
DiseaseRolandic epilepsy

KALRN PTPRM

7.67e-0416762Orphanet_1945
DiseaseFamilial primary pulmonary hypertension

SMAD1 SMAD9

8.68e-0417762C0340543
Diseasecerebellum cortex volume change measurement, age at assessment

TMC1 PTPRM

2.04e-0326762EFO_0008007, EFO_0021497

Protein segments in the cluster

PeptideGeneStartEntry
KEKLEKMMEKKGTKI

TTF1

836

Q15361
KKLKALEAMKNKQKS

ZNF385D

106

Q9H6B1
KQKKKMIKKPLERES

DDX52

551

Q9Y2R4
SVVKMEANQKAKKKK

BAHCC1

1691

Q9P281
KRKKKKMPEILKTEL

CDCA5

216

Q96FF9
HKNSMKKKAKIKNVT

EGFL6

286

Q8IUX8
KKLKSITMLRKKIVH

CDC14B

106

O60729
VKQIKMLKRESKKTE

CDKL3

541

Q8IVW4
EKLDKKLKKMEQNKT

ATF4

276

P18848
KEAKVKKLVVKVHMN

APBB1IP

171

Q7Z5R6
KKKVIMKKRKKLTLT

CPXM1

71

Q96SM3
KKLKSITMLRKKIVH

CDC14C

76

A4D256
AKKNKAMKSIKVKEE

CHD1

1336

O14646
KGKKKKINKNDIMLV

PCDH17

756

O14917
KVAVRKQRKKIKAKM

RILP

291

Q96NA2
KRKSKNLAKDMKNKL

RGS3

1021

P49796
KRLQMVKKKAAQKKL

INTS12

446

Q96CB8
SKEKKKKKSALDEIM

KIN

251

O60870
IKEKMKTVKHKILVL

NUBP1

46

P53384
MKKLKEVTDKKKTNL

nan

171

A8MVJ9
QMKKVVKTVAVKILK

SYK

391

P43405
KDMLEKKVKKVVVSN

HSP90AA5P

261

Q58FG0
KKMKKLEKEYTTIKT

EVI5

406

O60447
AVKFVSKKMKKKEQA

KALRN

2711

O60229
TKEKNKKVMFLPKKA

PACS2

806

Q86VP3
PAVIVDKKMQKKMKK

PRR13

101

Q9NZ81
KKKKTIKMLMLVVVL

GPR83

286

Q9NYM4
DLDIMLGNKKKKKKN

EIF2S2

116

P20042
KMKHKPTRQQKKVAK

OSBPL8

781

Q9BZF1
KSLDKQKKKTKMTDE

PAK2

216

Q13177
NEASKIMKKKKKVLV

C5orf47

126

Q569G3
EAVQSGKKKKKQKMV

GIGYF2

1256

Q6Y7W6
KKEKGKKLSRMKLLL

GNRHR

66

P30968
EKQKLKKKLKEGMLS

C5

1041

P01031
KINKIKLVAVKAKKE

GCC2

966

Q8IWJ2
KKVLKKMLKFLAKGE

ATE1

91

O95260
KMKKKIIKDQKLLVI

GABBR2

586

O75899
LAKLRQKKMKKSKEG

CCDC174

296

Q6PII3
NLAEVKKKGKMKKLG

HDAC6

46

Q9UBN7
EFKAKNIKKKKVSIM

NOS1AP

61

O75052
KVLKSKMKKRVVSIV

GPR22

376

Q99680
KERADKKILKVMKKN

DNAH2

1671

Q9P225
KKKTKVLKQRTVIEM

EHMT1

301

Q9H9B1
SLRNKEVKKAVKKML

OR5T3

321

Q8NGG3
VLVMKKRKLAKKRKE

PTPRM

761

P28827
KARKIEKKGTMKKQA

RTF1

116

Q92541
KIHLMQNGKRLKKKK

SYT2

311

Q8N9I0
TRKDLMDKTQKVKVK

UTP11

221

Q9Y3A2
GKLKKKKMAKRIQQV

TNP2

111

Q05952
LKALEAQKMMKKKKE

SPEF2

226

Q9C093
KKIKSPAKMAEKAKQ

RGS5

101

O15539
GVMLFKKKKTRKLKI

PLCZ1

331

Q86YW0
KSTMKKELEAAQKKK

SLC22A9

321

Q8IVM8
KNKKKMQKRADKIAS

GNL3L

546

Q9NVN8
PNIMKAKKKKIEVIK

ETFB

196

P38117
TRKLVKPKNTKMKTK

SIM2

366

Q14190
KKKMEVFKILNKKTK

CCDC59

206

Q9P031
SSKNKKKLEKAMKVL

SDAD1

256

Q9NVU7
LVKKLKKKKGAMDEL

SMAD9

41

O15198
DALVKKLKKKKGAME

SMAD5

36

Q99717
ALVKKLKKKKGAMEE

SMAD1

36

Q15797
KGQKAANLDLKKKMK

TMC1

721

Q8TDI8
ILSMKEDIKALKKKV

CCDC54

126

Q8NEL0
AKTAKKMDMKKLKQS

NCAPH

636

Q15003
KQKVMVAVKIISKKK

TSSK4

46

Q6SA08
TLEEIKSKKMKEKSK

ZC3H11A

216

O75152
SMAKKVKRLLKKQVV

UBE2O

381

Q9C0C9
IKEVVVTLMKKSEKK

VPS13C

1431

Q709C8
LMKKKRIVENDKSKI

SMC2

1001

O95347
LAKKKVMAPSKIKVK

UBN1

586

Q9NPG3
KKKKRKLTLTQMVGK

ERCC4

486

Q92889
MNTRNKVKIKKKKHQ

TGS1

116

Q96RS0
AVKIKETKVMKLRKL

MID2

301

Q9UJV3
KLSSKVMTKVIKKKI

TRANK1

801

O15050
GVLDKKTIKTINKMK

SETBP1

656

Q9Y6X0
KTIKTINKMKTLKRK

SETBP1

661

Q9Y6X0
KVKKARQIKKEMKAA

TRMT10C

141

Q7L0Y3
KSKIIKVKVQKKADM

UGGT1

1201

Q9NYU2
FKQEMEKMTKKIKKL

TXLNA

411

P40222
EKMTKKIKKLEKETT

TXLNA

416

P40222
KAKMVALKGIKKVMA

KMT2D

3426

O14686
MLKRLKKAKVEVKKS

MYBPC2

241

Q14324
VKKKLKEMKMSLEKA

PPP1R9A

1041

Q9ULJ8