Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	FZD4 MST1R AMHR2 OR2A7 IL31RA NRXN2 OR2A4 OR6J1 PTCH2 SMO IL17RA RET PTCH1 NFAM1 ADGRA3 TNFRSF4 FCMR	3.06e-06	1353	70	17	GO:0004888
GeneOntologyMolecularFunction	hedgehog receptor activity	PTCH2 PTCH1	3.63e-05	3	70	2	GO:0008158
GeneOntologyMolecularFunction	smoothened binding	PTCH2 PTCH1	7.24e-05	4	70	2	GO:0005119
GeneOntologyMolecularFunction	hedgehog family protein binding	PTCH2 PTCH1	7.24e-05	4	70	2	GO:0097108
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPP ALPG	1.80e-04	6	70	2	GO:0004035
GeneOntologyMolecularFunction	patched binding	SMO PTCH1	3.35e-04	8	70	2	GO:0005113
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	TMC6 TMC8	1.79e-03	18	70	2	GO:0008381
GeneOntologyMolecularFunction	cytokine binding	FZD4 IL31RA TMC8 LTBP3	2.25e-03	157	70	4	GO:0019955
GeneOntologyMolecularFunction	immune receptor activity	FZD4 IL31RA IL17RA FCMR	2.70e-03	165	70	4	GO:0140375
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	MST1R AMHR2 RET	3.32e-03	85	70	3	GO:0019199
GeneOntologyMolecularFunction	structural constituent of nuclear pore	POM121 POM121C	3.45e-03	25	70	2	GO:0017056
GeneOntologyCellularComponent	cell surface	FZD4 TSPAN15 CD93 MST1R FLT3LG IL31RA CD6 ITGA2B CLEC10A GPC6 ZZEF1 NFAM1 CDH1 ST14 SLC2A4 ADGRA3 ALPP ALPG TNFRSF4 FCMR	7.95e-10	1111	73	20	GO:0009986
GeneOntologyCellularComponent	side of membrane	FLT3LG IL31RA LYPD5 ITGA2B CLEC10A GPC6 CDH1 ST14 SLC2A4 ADGRA3 ALPP ALPG TNFRSF4 FCMR	1.69e-06	875	73	14	GO:0098552
GeneOntologyCellularComponent	external side of plasma membrane	FLT3LG IL31RA ITGA2B CLEC10A ST14 SLC2A4 ADGRA3 ALPP ALPG TNFRSF4 FCMR	1.76e-06	519	73	11	GO:0009897
GeneOntologyCellularComponent	nuclear membrane	POM121 ERN1 KASH5 TMC6 TMC8 NAT8 TMEM109 POM121C	2.91e-05	349	73	8	GO:0031965
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	FZD4 TSPAN15 CD93 KREMEN2 TMC6 CD68 SMO ITGA2B RET PTCH1 NFAM1 SLC2A4 FCMR	5.39e-04	1307	73	13	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	FZD4 TSPAN15 CD93 KREMEN2 TMC6 CD68 SMO ITGA2B RET PTCH1 NFAM1 SLC2A4 FCMR	6.13e-04	1325	73	13	GO:0012506
GeneOntologyCellularComponent	endosome	TSPAN15 TMUB1 OR2A7 OR2A4 KREMEN2 CD68 SMO SIGLEC1 RET CDH1 SLC2A4 FCMR	6.75e-04	1167	73	12	GO:0005768
GeneOntologyCellularComponent	nuclear envelope	POM121 ERN1 KASH5 TMC6 TMC8 NAT8 TMEM109 POM121C	7.35e-04	560	73	8	GO:0005635
GeneOntologyCellularComponent	dendritic growth cone	SMO PTCH1	7.76e-04	12	73	2	GO:0044294
GeneOntologyCellularComponent	mitotic spindle midzone	OR2A7 OR2A4	1.40e-03	16	73	2	GO:1990023
GeneOntologyCellularComponent	membrane raft	SELPLG SMO PTCH1 NFAM1 CDH1 SLC2A4	1.66e-03	362	73	6	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	SELPLG SMO PTCH1 NFAM1 CDH1 SLC2A4	1.71e-03	364	73	6	GO:0098857
GeneOntologyCellularComponent	plasma membrane raft	SELPLG SMO PTCH1 CDH1	1.75e-03	147	73	4	GO:0044853
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	POM121 ERN1 KASH5 TEX264 TMC6 TMC8 NAT8 OS9 TMEM119 TMEM109 POM121C SEZ6L2	2.04e-03	1327	73	12	GO:0042175
GeneOntologyCellularComponent	dendrite terminus	SMO PTCH1	2.19e-03	20	73	2	GO:0044292
HumanPheno	Odontogenic keratocysts of the jaw	PTCH2 PTCH1	6.92e-05	3	25	2	HP:0010603
HumanPheno	Cardiac fibroma	PTCH2 PTCH1	6.92e-05	3	25	2	HP:0010617
HumanPheno	Ovarian fibroma	PTCH2 PTCH1	6.92e-05	3	25	2	HP:0010618
HumanPheno	Bridged sella turcica	PTCH2 PTCH1	6.92e-05	3	25	2	HP:0005449
MousePheno	increased susceptibility to infection	MST1R FLT3LG IL31RA DSG3 LTA IL17RA SIGLEC1 CLEC10A CDH1 FCMR	3.73e-05	504	58	10	MP:0002406
MousePheno	abnormal leukocyte physiology	SELPLG CD93 MST1R MPZ FLT3LG IL31RA CD6 DSG3 SLC35C1 CD68 LTA IL17RA SIGLEC1 TMEM109 ST14 TNFRSF4 FCMR	4.26e-05	1425	58	17	MP:0002442
MousePheno	abnormal gestational length	COMT ALPP ALPG	5.29e-05	18	58	3	MP:0002292
MousePheno	abnormal immune cell physiology	SELPLG CD93 MST1R MPZ FLT3LG IL31RA CD6 DSG3 SLC35C1 CD68 LTA IL17RA SIGLEC1 TMEM109 ST14 TNFRSF4 FCMR	5.32e-05	1450	58	17	MP:0001819
MousePheno	abnormal cell-mediated immunity	SELPLG CD93 MST1R MPZ FLT3LG IL31RA CD6 DSG3 SLC35C1 CD68 LTA IL17RA SIGLEC1 TMEM109 ST14 TNFRSF4 FCMR	5.96e-05	1463	58	17	MP:0002421
MousePheno	abnormal adaptive immunity	SELPLG CD93 MST1R MPZ FLT3LG IL31RA CD6 DSG3 SLC35C1 CD68 LTA IL17RA SIGLEC1 TMEM109 ST14 TNFRSF4 FCMR	7.50e-05	1490	58	17	MP:0002420
MousePheno	dermal hyperplasia	PTCH2 PTCH1	1.68e-04	5	58	2	MP:0004971
Domain	TMEM191C	TMEM191B TMEM191C	1.35e-05	2	69	2	PF15194
Domain	TMEM191B/C	TMEM191B TMEM191C	1.35e-05	2	69	2	IPR028186
Domain	TM_rcpt_patched	PTCH2 PTCH1	1.35e-05	2	69	2	IPR004766
Domain	-	KREMEN2 ZZEF1 SEZ6L2 ST14	4.04e-05	52	69	4	2.60.120.290
Domain	CUB_dom	KREMEN2 ZZEF1 SEZ6L2 ST14	5.81e-05	57	69	4	IPR000859
Domain	Alk_phosphatase	ALPP ALPG	8.03e-05	4	69	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPP ALPG	8.03e-05	4	69	2	IPR018299
Domain	Alkaline_phosphatase	ALPP ALPG	8.03e-05	4	69	2	IPR001952
Domain	alkPPc	ALPP ALPG	8.03e-05	4	69	2	SM00098
Domain	ALKALINE_PHOSPHATASE	ALPP ALPG	8.03e-05	4	69	2	PS00123
Domain	TLV_coat	ERVS71-1 ERVFRD-1	2.79e-04	7	69	2	PF00429
Domain	TLV/ENV_coat_polyprotein	ERVS71-1 ERVFRD-1	3.71e-04	8	69	2	IPR018154
Domain	TMC	TMC6 TMC8	3.71e-04	8	69	2	PF07810
Domain	TMC	TMC6 TMC8	3.71e-04	8	69	2	IPR012496
Domain	Ptc/Disp	PTCH2 PTCH1	4.76e-04	9	69	2	IPR003392
Domain	Patched	PTCH2 PTCH1	4.76e-04	9	69	2	PF02460
Domain	Frizzled	FZD4 SMO	7.24e-04	11	69	2	IPR000539
Domain	Frizzled	FZD4 SMO	7.24e-04	11	69	2	PF01534
Domain	Frizzled	FZD4 SMO	7.24e-04	11	69	2	SM01330
Domain	CUB	KREMEN2 SEZ6L2 ST14	7.87e-04	49	69	3	PF00431
Domain	Cadherin	DSG3 DCHS1 RET CDH1	8.11e-04	113	69	4	PF00028
Domain	CUB	KREMEN2 SEZ6L2 ST14	8.35e-04	50	69	3	SM00042
Domain	CADHERIN_2	DSG3 DCHS1 RET CDH1	8.39e-04	114	69	4	PS50268
Domain	-	DSG3 DCHS1 RET CDH1	8.39e-04	114	69	4	2.60.40.60
Domain	CA	DSG3 DCHS1 RET CDH1	8.66e-04	115	69	4	SM00112
Domain	Cadherin-like	DSG3 DCHS1 RET CDH1	8.95e-04	116	69	4	IPR015919
Domain	Cadherin	DSG3 DCHS1 RET CDH1	9.54e-04	118	69	4	IPR002126
Domain	CUB	KREMEN2 SEZ6L2 ST14	9.90e-04	53	69	3	PS01180
Domain	SSD	PTCH2 PTCH1	1.02e-03	13	69	2	IPR000731
Domain	SSD	PTCH2 PTCH1	1.02e-03	13	69	2	PS50156
Domain	EamA_dom	SLC35F3 SLC35C1	1.19e-03	14	69	2	IPR000620
Domain	EamA	SLC35F3 SLC35C1	1.19e-03	14	69	2	PF00892
Domain	GPCR_2_secretin-like	FZD4 SMO ADGRA3	1.42e-03	60	69	3	IPR000832
Domain	GPCR_2-like	FZD4 SMO ADGRA3	1.42e-03	60	69	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	FZD4 SMO ADGRA3	1.49e-03	61	69	3	PS50261
Domain	Frizzled/SFRP	FZD4 SMO	1.56e-03	16	69	2	IPR015526
Domain	FRI	FZD4 SMO	2.45e-03	20	69	2	SM00063
Domain	-	FZD4 SMO	2.70e-03	21	69	2	1.10.2000.10
Domain	Frizzled_dom	FZD4 SMO	3.52e-03	24	69	2	IPR020067
Domain	FZ	FZD4 SMO	3.52e-03	24	69	2	PS50038
Domain	Fz	FZD4 SMO	3.52e-03	24	69	2	PF01392
Domain	Cadherin_cytoplasmic-dom	DSG3 CDH1	3.82e-03	25	69	2	IPR000233
Domain	Cadherin_C	DSG3 CDH1	3.82e-03	25	69	2	PF01049
Domain	cEGF	CD93 LTBP3	4.13e-03	26	69	2	IPR026823
Domain	cEGF	CD93 LTBP3	4.13e-03	26	69	2	PF12662
Domain	Ig-like_fold	NPHS1 MST1R MPZ IL31RA SIGLEC1 NFAM1 ADGRA3 FCMR	4.39e-03	706	69	8	IPR013783
Domain	IG	NPHS1 MPZ SIGLEC1 NFAM1 ADGRA3 FCMR	4.59e-03	421	69	6	SM00409
Domain	Ig_sub	NPHS1 MPZ SIGLEC1 NFAM1 ADGRA3 FCMR	4.59e-03	421	69	6	IPR003599
Domain	V-set	NPHS1 MPZ SIGLEC1 FCMR	4.79e-03	184	69	4	PF07686
Domain	Catenin_binding_dom	DSG3 CDH1	5.12e-03	29	69	2	IPR027397
Domain	-	DSG3 CDH1	5.12e-03	29	69	2	4.10.900.10
Domain	ig	NPHS1 SIGLEC1 ADGRA3 FCMR	5.36e-03	190	69	4	PF00047
Domain	Immunoglobulin	NPHS1 SIGLEC1 ADGRA3 FCMR	5.36e-03	190	69	4	IPR013151
Domain	Alkaline_phosphatase_core	ALPP ALPG	5.84e-03	31	69	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ALPP ALPG	5.84e-03	31	69	2	IPR017849
Domain	-	ALPP ALPG	5.84e-03	31	69	2	3.40.720.10
Domain	LRRCT	CHAD ADGRA3	6.21e-03	32	69	2	PF01463
Domain	Ig_V-set	NPHS1 MPZ SIGLEC1 FCMR	6.30e-03	199	69	4	IPR013106
Pathway	KEGG_CELL_ADHESION_MOLECULES_CAMS	SELPLG MPZ CD6 NRXN2 SIGLEC1 CDH1	8.98e-06	133	52	6	M16476
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 SMO PTCH1	1.67e-05	14	52	3	M47414
Pathway	KEGG_PATHWAYS_IN_CANCER	FZD4 FLT3LG PTCH2 SMO ITGA2B RET PTCH1 CDH1	2.28e-05	325	52	8	M12868
Pathway	WP_HEDGEHOG_SIGNALING_WP47	PTCH2 SMO PTCH1	2.56e-05	16	52	3	M39675
Pathway	KEGG_BASAL_CELL_CARCINOMA	FZD4 PTCH2 SMO PTCH1	4.89e-05	55	52	4	M17807
Pathway	PID_HEDGEHOG_2PATHWAY	PTCH2 SMO PTCH1	6.94e-05	22	52	3	M211
Pathway	WP_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 SMO PTCH1	6.94e-05	22	52	3	MM15924
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 SMO PTCH1	1.62e-04	29	52	3	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 SMO PTCH1	1.62e-04	29	52	3	M47377
Pathway	WP_HAIR_FOLLICLE_DEVELOPMENT_ORGANOGENESIS_STAGE_2_OF_3	SMO PTCH1 CDH1	2.18e-04	32	52	3	M40041
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	PTCH2 PTCH1	2.77e-04	7	52	2	M27501
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	FZD4 PTCH2 SMO PTCH1	3.93e-04	94	52	4	M797
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	PTCH2 PTCH1	4.73e-04	9	52	2	M47893
Pathway	WP_CANCER_PATHWAYS	FZD4 FLT3LG PTCH2 SMO ITGA2B RET PTCH1 CDH1	4.94e-04	507	52	8	M48302
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	PTCH2 SMO PTCH1	5.26e-04	43	52	3	M39706
Pathway	KEGG_FOLATE_BIOSYNTHESIS	ALPP ALPG	7.19e-04	11	52	2	M2220
Pathway	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS	DSG3 CDH1	7.19e-04	11	52	2	M9990
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 SMO PTCH1	1.14e-03	56	52	3	M1053
Pathway	REACTOME_ACTIVATION_OF_SMO	SMO PTCH1	1.18e-03	14	52	2	MM15228
Pathway	BIOCARTA_SHH_PATHWAY	SMO PTCH1	1.36e-03	15	52	2	MM1498
Pubmed	An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea.	PTCH2 CHAD SMO PTCH1 CDH1	3.35e-09	28	73	5	35112129
Pubmed	Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.	PTCH2 SMO PTCH1 ALPP ALPG	4.85e-09	30	73	5	26057579
Pubmed	[Exploring parent-of-origin effects for non-syndromic cleft lip with or without cleft palate on PTCH1, PTCH2, SHH, SMO genes in Chinese case-parent trios].	PTCH2 SMO PTCH1	3.54e-08	4	73	3	33047712
Pubmed	Patched1 and Patched2 inhibit Smoothened non-cell autonomously.	PTCH2 SMO PTCH1	8.84e-08	5	73	3	27552050
Pubmed	Ret is critical for podocyte survival following glomerular injury in vivo.	NPHS1 RET CDH1	8.84e-08	5	73	3	25587123
Pubmed	An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome.	PTCH2 SMO PTCH1 CDH1	1.27e-07	22	73	4	28380258
Pubmed	Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization.	PTCH2 SMO PTCH1 CDH1	1.84e-07	24	73	4	12403705
Pubmed	Characterization of two patched receptors for the vertebrate hedgehog protein family.	PTCH2 SMO PTCH1	3.09e-07	7	73	3	9811851
Pubmed	A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification.	PTCH2 SMO PTCH1 CDH1	4.08e-07	29	73	4	27320915
Pubmed	Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient.	PTCH2 PTCH1 CDH1	4.93e-07	8	73	3	27498049
Pubmed	A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.	PTCH2 SMO PTCH1	4.93e-07	8	73	3	22869526
Pubmed	Cyclic expression of lhx2 regulates hair formation.	SMO PTCH1 CDH1	7.38e-07	9	73	3	20386748
Pubmed	The Shh signalling pathway in early tooth development.	PTCH2 SMO PTCH1	1.05e-06	10	73	3	10512189
Pubmed	Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.	PTCH2 SMO PTCH1	1.05e-06	10	73	3	28344083
Pubmed	Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.	PTCH2 SMO PTCH1	1.05e-06	10	73	3	11311154
Pubmed	Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.	PTCH2 SMO PTCH1	1.45e-06	11	73	3	15668330
Pubmed	Immunity to the microbiota promotes sensory neuron regeneration.	LTA IL17RA TNFRSF4	1.93e-06	12	73	3	36640762
Pubmed	Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.	PTCH2 SMO PTCH1	1.93e-06	12	73	3	36459481
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	PTCH2 SMO PTCH1	1.93e-06	12	73	3	10981962
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	PTCH2 SMO PTCH1	1.93e-06	12	73	3	18417110
Pubmed	A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.	CDH1 ALPP ALPG	1.93e-06	12	73	3	27802136
Pubmed	Expression patterns of Hedgehog signalling pathway members during mouse palate development.	PTCH2 SMO PTCH1	2.50e-06	13	73	3	16168717
Pubmed	Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis.	SMO PTCH1 CDH1	2.50e-06	13	73	3	26702830
Pubmed	Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.	NPHS1 PTCH1 CDH1	2.50e-06	13	73	3	21406566
Pubmed	Gli2 influences proliferation in the developing lung through regulation of cyclin expression.	PTCH2 SMO PTCH1	2.50e-06	13	73	3	19574535
Pubmed	Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate.	SMO PTCH1 CDH1	2.50e-06	13	73	3	27633995
Pubmed	Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.	SMO PTCH1 CDH1	3.96e-06	15	73	3	34486668
Pubmed	A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.	PTCH2 SMO PTCH1	3.96e-06	15	73	3	25458012
Pubmed	A role for smoothened during murine lens and cornea development.	SMO PTCH1 CDH1	3.96e-06	15	73	3	25268479
Pubmed	Sonic hedgehog signaling is essential for hair development.	PTCH2 SMO PTCH1	3.96e-06	15	73	3	9768360
Pubmed	Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.	SMO PTCH1	4.35e-06	2	73	2	22864913
Pubmed	Purification and partial sequencing of human placental alkaline phosphatase.	ALPP ALPG	4.35e-06	2	73	2	6651840
Pubmed	Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells.	SMO PTCH1	4.35e-06	2	73	2	16867986
Pubmed	Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia.	SMO PTCH1	4.35e-06	2	73	2	16804411
Pubmed	The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.	PTCH2 PTCH1	4.35e-06	2	73	2	30166346
Pubmed	Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.	ALPP ALPG	4.35e-06	2	73	2	11124260
Pubmed	Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.	ALPP ALPG	4.35e-06	2	73	2	3461452
Pubmed	DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements.	RET PTCH1	4.35e-06	2	73	2	28069693
Pubmed	Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells.	ALPP ALPG	4.35e-06	2	73	2	3459156
Pubmed	Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein.	ALPP ALPG	4.35e-06	2	73	2	1730777
Pubmed	PTCH1 and SMO gene alterations in keratocystic odontogenic tumors.	SMO PTCH1	4.35e-06	2	73	2	18502968
Pubmed	Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations.	TMC6 TMC8	4.35e-06	2	73	2	26227733
Pubmed	Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA.	ALPP ALPG	4.35e-06	2	73	2	3001717
Pubmed	Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation.	TMC6 TMC8	4.35e-06	2	73	2	19706093
Pubmed	Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis.	TMC6 TMC8	4.35e-06	2	73	2	12426567
Pubmed	EVER proteins, key elements of the natural anti-human papillomavirus barrier, are regulated upon T-cell activation.	TMC6 TMC8	4.35e-06	2	73	2	22761942
Pubmed	Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway.	RET PTCH1	4.35e-06	2	73	2	39290714
Pubmed	Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice.	SMO PTCH1	4.35e-06	2	73	2	16598417
Pubmed	Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution.	ALPP ALPG	4.35e-06	2	73	2	3042787
Pubmed	Real-time quantitative RT-PCR identifies distinct c-RET, RET/PTC1 and RET/PTC3 expression patterns in papillary thyroid carcinoma.	RET PTCH1	4.35e-06	2	73	2	15502856
Pubmed	[Dose-Response Dependences for Frequency of RET/PTC Gene Rearrangements in Papillary Thyroid Carcinoma after Irradiation. Simple Pooling Analysis of Molecular Epidemiological Data].	RET PTCH1	4.35e-06	2	73	2	27245001
Pubmed	Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.	PTCH2 PTCH1	4.35e-06	2	73	2	29230040
Pubmed	Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.	SMO PTCH1	4.35e-06	2	73	2	27162362
Pubmed	[Expression of PTCH-1 and SMO mRNA in nasopharyngeal carcinoma].	SMO PTCH1	4.35e-06	2	73	2	20937227
Pubmed	SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.	SMO PTCH1	4.35e-06	2	73	2	31873117
Pubmed	Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.	ALPP ALPG	4.35e-06	2	73	2	3422741
Pubmed	Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility.	TMC6 TMC8	4.35e-06	2	73	2	21387292
Pubmed	Genetic variations in the epidermodysplasia verruciformis (EVER/TMC) genes, cutaneous human papillomavirus infection and squamous cell carcinoma of the skin.	TMC6 TMC8	4.35e-06	2	73	2	26126409
Pubmed	Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus.	TMC6 TMC8	4.35e-06	2	73	2	25378492
Pubmed	Mutations in the hedgehog pathway genes SMO and PTCH1 in human gastric tumors.	SMO PTCH1	4.35e-06	2	73	2	23349881
Pubmed	Mutation of a single amino acid converts germ cell alkaline phosphatase to placental alkaline phosphatase.	ALPP ALPG	4.35e-06	2	73	2	1939159
Pubmed	Hedgehog signaling is required for effective regeneration of exocrine pancreas.	SMO PTCH1	4.35e-06	2	73	2	18515092
Pubmed	Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.	PTCH2 PTCH1	4.35e-06	2	73	2	26834157
Pubmed	Molecular cloning and expression analysis of the Hedgehog receptors XPtc1 and XSmo in Xenopus laevis.	SMO PTCH1	4.35e-06	2	73	2	11165486
Pubmed	Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25.	TMC6 TMC8	4.35e-06	2	73	2	10844558
Pubmed	Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.	SMO PTCH1	4.35e-06	2	73	2	34698632
Pubmed	A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction.	SMO PTCH1	4.35e-06	2	73	2	26126827
Pubmed	Desmoglein-3/γ-catenin and E-cadherin/ß-catenin differential expression in oral leukoplakia and squamous cell carcinoma.	DSG3 CDH1	4.35e-06	2	73	2	23430339
Pubmed	Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.	ALPP ALPG	4.35e-06	2	73	2	2153284
Pubmed	Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.	SMO PTCH1	4.35e-06	2	73	2	22186138
Pubmed	Patched and smoothened mRNA expression in human astrocytic tumors inversely correlates with histological malignancy.	SMO PTCH1	4.35e-06	2	73	2	12241103
Pubmed	Inherited rare and common variants in PTCH1 and PTCH2 contributing to the predisposition to reproductive cancers.	PTCH2 PTCH1	4.35e-06	2	73	2	34990798
Pubmed	Variants of EVER1 and EVER2 (TMC6 and TMC8) and human papillomavirus status in patients with mucosal squamous cell carcinoma of the head and neck.	TMC6 TMC8	4.35e-06	2	73	2	27097911
Pubmed	Molecular cloning and sequence analysis of human placental alkaline phosphatase.	ALPP ALPG	4.35e-06	2	73	2	3512548
Pubmed	Implicating clinical utility of altered expression of PTCH1 & SMO in oral squamous cell carcinoma.	SMO PTCH1	4.35e-06	2	73	2	38954185
Pubmed	Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.	SMO PTCH1	4.35e-06	2	73	2	18772113
Pubmed	Patched-one or smoothened gene mutations are infrequent in chondrosarcoma.	SMO PTCH1	4.35e-06	2	73	2	18543049
Pubmed	RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.	SMO PTCH1	4.35e-06	2	73	2	26130651
Pubmed	[Studies on keratocystic odontogenic tumors].	PTCH2 PTCH1	4.35e-06	2	73	2	19221557
Pubmed	Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion.	DSG3 CDH1	4.35e-06	2	73	2	27254775
Pubmed	Merkel cell polyomavirus detection in a patient with familial epidermodysplasia verruciformis.	TMC6 TMC8	4.35e-06	2	73	2	23535066
Pubmed	Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1.	SIGLEC1 CLEC10A	4.35e-06	2	73	2	15364954
Pubmed	Patched acts catalytically to suppress the activity of Smoothened.	SMO PTCH1	4.35e-06	2	73	2	12192414
Pubmed	Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0.	MPZ SIGLEC1	4.35e-06	2	73	2	16458537
Pubmed	Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.	SMO ITGA2B PTCH1	4.87e-06	16	73	3	26457609
Pubmed	Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney.	FZD4 RET CDH1	4.87e-06	16	73	3	21343368
Pubmed	Tracing the origin of adult intestinal stem cells.	CDH1 ALPP ALPG	4.87e-06	16	73	3	31092921
Pubmed	Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.	PTCH2 PTCH1 CDH1	4.87e-06	16	73	3	29109083
Pubmed	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.	PTCH2 SMO PTCH1	4.87e-06	16	73	3	26932670
Pubmed	Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.	PTCH2 PTCH1 CDH1	4.87e-06	16	73	3	23034632
Pubmed	iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging.	NPHS1 RET CDH1	4.87e-06	16	73	3	25417164
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	TMUB1 IL31RA LYPD5 TMEM119 ITGA2B GPC6 SEZ6L2 ADGRA3	5.58e-06	460	73	8	20562862
Pubmed	Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice.	AMHR2 SMO PTCH1	5.91e-06	17	73	3	22402963
Pubmed	Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.	KREMEN2 LTA PTCH1	5.91e-06	17	73	3	16738056
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	TSPAN15 TMUB1 IL31RA TEX264 LYPD5 PTCH2 TMEM119 GPC6 SEZ6L2 ADGRA3 ERVFRD-1	6.37e-06	985	73	11	12975309
Pubmed	GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.	SMO RET PTCH1	7.08e-06	18	73	3	19809516
Pubmed	Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development.	SMO RET PTCH1	8.39e-06	19	73	3	21831920
Pubmed	Genetic mutations associated with cigarette smoking in pancreatic cancer.	SMO RET PTCH1 CDH1	9.69e-06	63	73	4	19351817
Pubmed	Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.	CDH1 ALPP ALPG	9.86e-06	20	73	3	26023099
Pubmed	Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.	PTCH2 SMO PTCH1	9.86e-06	20	73	3	32702291
Interaction	PCDHGB5 interactions	POM121 ERN1 TEX264 RET POM121C	3.05e-07	43	67	5	int:PCDHGB5
Interaction	SPINT2 interactions	TMUB1 POM121 TEX264 RET POM121C ST14	6.55e-06	138	67	6	int:SPINT2
Interaction	BTNL2 interactions	MST1R BRI3BP CACNA2D2 KREMEN2 ST14 ADGRA3	1.27e-05	155	67	6	int:BTNL2
Interaction	GXYLT1 interactions	KREMEN2 OS9 IL17RA ST14 ALPP	1.87e-05	98	67	5	int:GXYLT1
Interaction	POGLUT1 interactions	OS9 PTCH1 ZZEF1 ST14 ALPP	3.56e-05	112	67	5	int:POGLUT1
Interaction	BRICD5 interactions	MST1R CACNA2D2 KREMEN2 OS9 ADGRA3 BIK	4.51e-05	194	67	6	int:BRICD5
Interaction	LYZL1 interactions	CACNA2D2 OS9 IL17RA ZZEF1 ST14	4.57e-05	118	67	5	int:LYZL1
Interaction	ANKRD46 interactions	KASH5 PTCH1 ST14 ALPP BIK	7.25e-05	130	67	5	int:ANKRD46
Interaction	HMOX1 interactions	TSPAN15 KASH5 TEX264 OR2A4 SMO	7.25e-05	130	67	5	int:HMOX1
Interaction	SFTPC interactions	MST1R POM121 CACNA2D2 SEZ6L2 ST14 ADGRA3	9.52e-05	222	67	6	int:SFTPC
Interaction	SDF2L1 interactions	MST1R CACNA2D2 IL17RA ITGA2B RET SEZ6L2 SLC2A4	9.53e-05	322	67	7	int:SDF2L1
Interaction	ISLR interactions	CACNA2D2 TEX264 OS9 IL17RA POM121C	9.62e-05	138	67	5	int:ISLR
Interaction	PCOLCE2 interactions	OS9 ST14 ALPG	1.08e-04	28	67	3	int:PCOLCE2
Interaction	BCL2L2 interactions	KASH5 CDH1 ERVFRD-1 BIK	1.46e-04	80	67	4	int:BCL2L2
Interaction	MFSD14B interactions	COMT NAT8 TMEM119 ZFPL1	1.46e-04	80	67	4	int:MFSD14B
Interaction	IHH interactions	PTCH2 PTCH1	1.62e-04	6	67	2	int:IHH
Interaction	SHISA3 interactions	POM121 TEX264 POM121C	1.78e-04	33	67	3	int:SHISA3
Interaction	B3GALT4 interactions	CACNA2D2 POM121C SEZ6L2	1.78e-04	33	67	3	int:B3GALT4
Interaction	LYZL2 interactions	CACNA2D2 OS9 IL17RA ZZEF1	1.84e-04	85	67	4	int:LYZL2
Interaction	FAM209A interactions	COMT TEX264 NAT8 PTCH1 ZFPL1 BIK	2.30e-04	261	67	6	int:FAM209A
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	TMEM88 CD68 CLEC10A ZZEF1 SLC2A4	2.19e-04	346	72	5	chr17p13
Cytoband	22q11.21	COMT TMEM191B TMEM191C	7.27e-04	111	72	3	22q11.21
Cytoband	11q13	CD6 NRXN2 ZFPL1	8.67e-04	118	72	3	11q13
Cytoband	2q37	ALPP ALPG	1.10e-03	31	72	2	2q37
Cytoband	17p13	CD68 SLC2A4	1.32e-03	34	72	2	17p13
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	FZD4 SELPLG CD93 MST1R CD6 CD68 IL17RA SIGLEC1 ITGA2B CLEC10A CDH1 TNFRSF4	7.16e-10	394	51	12	471
GeneFamily	Alkaline phosphatases	ALPP ALPG	4.66e-05	4	51	2	1072
GeneFamily	Transmembrane channel likes	TMC6 TMC8	2.16e-04	8	51	2	1135
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD4 SMO	4.22e-04	11	51	2	286
GeneFamily	Cadherin related	DCHS1 RET	1.03e-03	17	51	2	24
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	NPHS1 SIGLEC1	5.68e-03	40	51	2	592
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	MST1R RET	5.68e-03	40	51	2	321
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL31RA IL17RA	6.25e-03	42	51	2	602
GeneFamily	Adenosine receptors\|V-set domain containing	NPHS1 MPZ SIGLEC1	1.09e-02	163	51	3	590
GeneFamily	Proteases, serine	PRSS38 ST14	1.37e-02	63	51	2	738
Coexpression	BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	TMEM88 CD93 OR2A7 CACNA2D2 OR2A4 KREMEN2 LYPD5 DCHS1 IL17RA ITGA2B PTCH1 ZZEF1 SEZ6L2 CDH1	1.67e-07	930	71	14	MM893
Coexpression	BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	TMEM88 CD93 OR2A7 CACNA2D2 KREMEN2 LYPD5 DCHS1 IL17RA ITGA2B PTCH1 ZZEF1 SEZ6L2 CDH1	7.69e-07	899	71	13	M2242
Coexpression	GSE30083_SP2_VS_SP4_THYMOCYTE_DN	SELPLG CD68 IL17RA CLEC10A CDH1 ST14	1.74e-05	200	71	6	M5035
Coexpression	GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_FETAL_UP	CD93 RNASE4 CD68 TMEM119 CLEC10A NFAM1	1.74e-05	200	71	6	M4570
Coexpression	GSE17721_0.5H_VS_24H_CPG_BMDC_UP	CD93 RNASE4 CD6 COMT TEX264 CLEC10A	1.74e-05	200	71	6	M4128
Coexpression	GSE23568_ID3_TRANSDUCED_VS_ID3_KO_CD8_TCELL_UP	SELPLG FLT3LG CD6 TEX264 TMC6 TNFRSF4	1.74e-05	200	71	6	M8517
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	TSPAN15 CACNA2D2 KREMEN2 TMC6 PTCH2 SMO IL17RA RET CDH1 ST14 SLC2A4 BIK	2.89e-05	1074	71	12	M1941
ToppCell	NS-moderate-d_16-33-Lymphoid-Treg\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLT3LG CD6 TMC6 TMC8 LTA TNFRSF4 FCMR	2.69e-08	192	72	7	48d557071bad80edd3ec6e5ad8dcd97037da9553
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-Treg\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SELPLG FLT3LG CD6 TMC8 LTA TNFRSF4 FCMR	2.69e-08	192	72	7	0deb6aa323e1de72ee8a2002449e523dd4f0bf5d
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPZ RNASE4 SLC10A5 CD68 SIGLEC1 CLEC10A	2.84e-07	165	72	6	47e716ce8dc283d406352c1909e09362fcb9e3a3
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPZ RNASE4 SLC10A5 CD68 SIGLEC1 CLEC10A	2.84e-07	165	72	6	fe2135fdacf3807eb4b5ea5e790febfb8cd54335
ToppCell	facs-Aorta-Heart-24m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG BRI3BP CD68 CLEC10A NFAM1 CDH1	3.75e-07	173	72	6	d0d1c8bcef3d9c28ee9a7c64076624b836cb2580
ToppCell	Posterior_cortex-Hematopoietic\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SELPLG RNASE4 CD68 TMEM119 CLEC10A NFAM1	4.43e-07	178	72	6	ea9e4f461dda34c0ebc707d7dbefc7a49ce5bb55
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	4.58e-07	179	72	6	a634ca46ffc394c5f5215fc5d8eae4a77819af9c
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	4.58e-07	179	72	6	35f014b6e752626909d829c5ab9bb761c1f3e3dc
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SMIM35 CLEC10A FCMR	5.74e-07	186	72	6	6575ec6a626cdea169ffd185d47828dfaa29475d
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TMC8 CD68 SMIM35 CLEC10A NFAM1 FCMR	5.92e-07	187	72	6	23be50d81f4404a609dea821e1a66d221c0e0615
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRI3BP TEX264 OS9 TMEM119 ITGA2B CDH1	6.11e-07	188	72	6	7e27e49ec1eb02fb74c86ec2ccb84751bc778b21
ToppCell	droplet-Marrow-nan-21m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRI3BP TEX264 OS9 TMEM119 ITGA2B CDH1	6.11e-07	188	72	6	4b14c3ad80507245564d5be96d33fd9361f67dd0
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SMIM35 SIGLEC1 FCMR	6.50e-07	190	72	6	081b7bc07b6e5685e8a91b9ae6c1141623723700
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SMIM35 SIGLEC1 FCMR	6.50e-07	190	72	6	912aa106581d1ed7e147c92f9a367e8e6b04052b
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-Treg\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SELPLG FLT3LG CD6 TMC8 LTA FCMR	6.50e-07	190	72	6	fe6fecdf2123f3a4fb20e7535472d562b1a74fb4
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SMIM35 SIGLEC1 FCMR	6.70e-07	191	72	6	bce138f067b8962ecef1ddec6511a3f142d81d78
ToppCell	NS-critical-d_07-13-Lymphoid-Treg\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLT3LG CD6 TMC8 LTA TNFRSF4 FCMR	6.90e-07	192	72	6	cd34defac6565d34db507918e791b09c79f7d1f8
ToppCell	moderate-Lymphoid-Treg\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLT3LG CD6 TMC6 TMC8 TNFRSF4 FCMR	6.90e-07	192	72	6	e370ff5aaff7b7042ba9aaf93de43aa563b8b9f9
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SMIM35 SIGLEC1 FCMR	6.90e-07	192	72	6	4e3deefd30adb7bf1eba294610eed3d077aa9418
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-CD8_T\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SELPLG FLT3LG CD6 TMC8 LTA FCMR	6.90e-07	192	72	6	375817f1b813d7b2be10738c05611e1d1ba23055
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-Treg\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELPLG CD6 TMC8 LTA TNFRSF4 FCMR	7.12e-07	193	72	6	f3eb295a019de29f484964f00ea436860af249a5
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC-pDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SELPLG ERN1 SLC35F3 RET TMEM109 ST14	7.12e-07	193	72	6	2a48e72f3df2ad64e1680fca759be8fd2190771e
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	7.34e-07	194	72	6	c30b6d1fd5fabd99e25857f7486d6dc9c054f552
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	7.34e-07	194	72	6	749cc39cbe5d68372fc43f7dbdbe5004cd01ace8
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	7.34e-07	194	72	6	a7f11ac46965b3fc21c9d04870ce0bd2b3868cec
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SIGLEC1 CLEC10A FCMR	7.34e-07	194	72	6	fad22d5cf62016cad979e6943e357106d8d2a4b4
ToppCell	Control-T/NK-CD4+_T_1\|Control / Disease group,lineage and cell class （2021.01.30）	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	7.34e-07	194	72	6	908cc9a3b0b99aea28a24bbd27667c824743e967
ToppCell	PCW_07-8.5-Hematologic_Myeloid\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SMIM35 SIGLEC1 FCMR	7.34e-07	194	72	6	260649f5c4aeaa9cbf5ed5ae5e9f293d75bb0457
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CD68 SMIM35 SIGLEC1 CLEC10A NFAM1 FCMR	7.56e-07	195	72	6	799992721369357484300fe218aff075154c3148
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	7.56e-07	195	72	6	068210aa57e733cbcb54a0b20616f0cb2a1ff639
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	7.56e-07	195	72	6	b765fa52dcfad9069b74fce342d809d10abede39
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-SELL+_CD4_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELPLG FLT3LG CD6 ERN1 TMC8 FCMR	7.56e-07	195	72	6	8687b319f1f487fbef4ca075fad054751a641de6
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELPLG TMC8 CD68 SMIM35 SIGLEC1 FCMR	7.56e-07	195	72	6	518cc3baeb7cf2ad068692cbe85fd75be67f1872
ToppCell	cellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SELPLG FLT3LG CD6 TMC8 LTA FCMR	7.56e-07	195	72	6	e17d05b9ef5e63b49385ddb2fbdc2ade9ea8723f
ToppCell	PCW_05-06-Hematologic_Myeloid\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TMC8 CD68 SMIM35 SIGLEC1 CLEC10A FCMR	7.79e-07	196	72	6	b2aee2f67da373a10b0c25e7797e30e3811543a8
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TMC8 CD68 SMIM35 SIGLEC1 NFAM1 FCMR	7.79e-07	196	72	6	ce3709adbde7559b40c964888935914f66003247
ToppCell	COVID-19-Lymphoid-CD4_T_cells\|Lymphoid / Condition, Lineage and Cell class	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	7.79e-07	196	72	6	28515d8e2f02366fa0ac1bea251a7a3f659c98c7
ToppCell	Severe-Lymphoid-T-Treg\|Severe / Condition, Lineage, Cell class and cell subclass	SELPLG FLT3LG CD6 LTA TNFRSF4 FCMR	7.79e-07	196	72	6	29d4db6816fead2ad9136ef824e0775463b02159
ToppCell	18-Airway-Immune-Hematopoietic,_T_Cells\|Airway / Age, Tissue, Lineage and Cell class	SELPLG FLT3LG CD6 TMC8 LTA FCMR	8.02e-07	197	72	6	ba40a8b6871c8a0166195c03e7e3deae5834ec56
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.02e-07	197	72	6	b4f801cd48955463285e0c1bb4fc8ea790c631cb
ToppCell	Mild_COVID-19-T/NK-CD4+_T_1\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.02e-07	197	72	6	98fca0a2e2f66525c5c9d6cdaebcad14b4d53da4
ToppCell	Control-Lymphoid-CD4_T_cells\|Control / Condition, Lineage and Cell class	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.02e-07	197	72	6	dad6479caac07c1536f2b3082a51d61ae08beca0
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_1\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.02e-07	197	72	6	821c1df511cc4a286ddc6fa229059561f6f6bade
ToppCell	Severe_COVID-19-T/NK-CD4+_T_1\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.26e-07	198	72	6	bc6b983fdb9547ef8a9e693bc15fced1b73e101f
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.26e-07	198	72	6	fc8099bce80d84b29bdcc87064d4d8375dddfa0f
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid-Microglia\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SELPLG TMC6 TMC8 CD68 IL17RA ST14	8.26e-07	198	72	6	901cd39cb84f1907f2f5d27221979c854bd3b40e
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SELPLG TMC6 TMC8 CD68 IL17RA ST14	8.26e-07	198	72	6	cc292aa8518d5ef8940e2327f2f07d584a996d90
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.26e-07	198	72	6	32ec322ed144c545014b191da5274d12feeaf96b
ToppCell	10x3'2.3-week_17-19-Myeloid_monocytic-monocyte-promonocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SELPLG CD93 IL31RA CD68 IL17RA CLEC10A	8.26e-07	198	72	6	a11de3836fc1575bec5f6c701836fe2fb5a1027a
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4\|GI_small-bowel / Manually curated celltypes from each tissue	TSPAN15 FLT3LG CD6 ERN1 LTA TNFRSF4	8.26e-07	198	72	6	6333e46cd1ccf5841ce15aea98a4b2f5e3ae4675
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.26e-07	198	72	6	223c9986a213d8b22a348719c481b68b8f640f31
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.26e-07	198	72	6	1e281d8f0291e8cf814e9e5abd7f5860402a7c77
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.26e-07	198	72	6	74f190d8e337cff5ffb65d446cf784759e1c2a59
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.51e-07	199	72	6	4669b6be3b513d80b6f79bd10a1974fefdf58093
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.51e-07	199	72	6	b270d8274249103d3a1b4a4f8601c92fde007ed7
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SELPLG FLT3LG CD6 TMC8 LTA FCMR	8.51e-07	199	72	6	c9e1ac9f0fba23250a5df4052559d18d16df4521
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.51e-07	199	72	6	a1b127f12fa2057d6f2a976a139301a028a3f957
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-CD4_T\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SELPLG FLT3LG CD6 TMC8 LTA FCMR	8.51e-07	199	72	6	992bc4f0dc4189f18773c55976eb124c3827e08b
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-CD8_T\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SELPLG FLT3LG CD6 TMC8 LTA FCMR	8.51e-07	199	72	6	9a4eab4349aceeb07b4c515814dadda3e8ea8f6d
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RNASE4 POM121 PRSS38 KREMEN2 LTBP3 POM121C	8.51e-07	199	72	6	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	COVID-19-Lymphoid-CD4_T_cells\|COVID-19 / Condition, Lineage and Cell class	FLT3LG CD6 ERN1 LTA TNFRSF4 FCMR	8.51e-07	199	72	6	27ac7ad2f4c2028c355632cbb81f2b52439b85ad
ToppCell	Sigmoid-Macrophage-Macrophage\|Sigmoid / Region, Cell class and subclass	TSPAN15 CD93 CD68 SIGLEC1 CLEC10A ST14	8.76e-07	200	72	6	9ee3a799de7bade1bfe94b6827461633f02bc1dc
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLT3LG CD6 TMC8 LTA TNFRSF4 FCMR	8.76e-07	200	72	6	80f91fbb0779fa9bc2e8230ce70fced90946ea63
ToppCell	Sigmoid-(6)_Macrophage-(60)_Macrophage\|Sigmoid / shred on region, Cell_type, and subtype	TSPAN15 CD93 CD68 SIGLEC1 CLEC10A ST14	8.76e-07	200	72	6	ad84a83a5a1893f7b053d39eddeca851463a8ff0
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SELPLG FLT3LG CD6 TMC8 LTA FCMR	8.76e-07	200	72	6	3154d5c4fef8848473f5317606f860549a92c23c
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SELPLG MPZ CD68 CLEC10A NFAM1	3.21e-06	140	72	5	8db98a17a4d4b42dbfc75e9cdaa22275fed4f2f0
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia.C1qb.Tmem119-Fos)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SELPLG MPZ CD68 CLEC10A NFAM1	3.21e-06	140	72	5	22098203361f61b9f0ce9f0f2d1369d8bb1379a8
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SELPLG MPZ CD68 CLEC10A NFAM1	3.21e-06	140	72	5	2c04fa782aa076e4be8a2781aa04231180bd69bd
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia.C1qb.Tmem119-Fos)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SELPLG MPZ CD68 CLEC10A NFAM1	3.21e-06	140	72	5	a9389a6e55d02d5037868c9ecce48b5e8d7c2902
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC35C1 TMEM191C CD68 CLEC10A NFAM1	3.95e-06	146	72	5	69cbe8d4772f8e46a5e1a1cdca0e370308a97b4f
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMUB1 TMC8 SMIM35 IL17RA NFAM1	5.80e-06	158	72	5	b0508a600994090c6aafd8d779437190a33ad821
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD6 KREMEN2 LTA CDH1	5.80e-06	158	72	5	b1b1e50ddd231dcd10cc8e6bb68b2a5e0bb1450a
ToppCell	facs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMUB1 TMC8 SMIM35 IL17RA NFAM1	5.80e-06	158	72	5	a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IL31RA CD68 SMIM35 IL17RA NFAM1	5.80e-06	158	72	5	121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tregs\|Lung / Manually curated celltypes from each tissue	FLT3LG SLC35F3 LTA TNFRSF4 FCMR	5.80e-06	158	72	5	f433bc189f000efa34e8e09ab32b3fa22bcf64c4
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-Microglia_Siglech\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SELPLG RNASE4 CD68 TMEM119 NFAM1	6.17e-06	160	72	5	c3f2f362e5d0602bb997e8367b4c9a8fe88e4ea8
ToppCell	droplet-Lung-nan-21m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRI3BP CD68 IL17RA SEZ6L2 NFAM1	6.17e-06	160	72	5	0b8151037b28f52a21918856a1e9336e8d5edb90
ToppCell	IPF-Epithelial-Ionocyte\|IPF / Disease state, Lineage and Cell class	SLC35F3 RET GPC6 CDH1 BIK	6.17e-06	160	72	5	d65d19f4fae60836bfd4303a1bb7de34e9d83e35
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELPLG CD6 SLC35C1 KREMEN2 TNFRSF4	6.17e-06	160	72	5	ec81814f3a475ba9bc049cb793bf93bc0b650d37
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IL31RA CD68 SMIM35 IL17RA NFAM1	6.17e-06	160	72	5	bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL31RA CD68 SMIM35 IL17RA NFAM1	6.17e-06	160	72	5	2020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCell	droplet-Lung-nan-21m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRI3BP CD68 IL17RA SEZ6L2 NFAM1	6.17e-06	160	72	5	4738d0c73d8c3508e5b5beb6c61e0ad551d9b949
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL31RA CD68 SMIM35 IL17RA NFAM1	6.17e-06	160	72	5	af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSPAN15 AMHR2 KREMEN2 CDH1 TNFRSF4	6.55e-06	162	72	5	34b4cd3d2258f88dfbd6d32abd1db87aff8a6b6f
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs\|GI_large-bowel / Manually curated celltypes from each tissue	SLC35F3 SLC10A5 LYPD5 TNFRSF4 FCMR	6.55e-06	162	72	5	9a5e65c45f73a6a685b8362aa2e6aea77181caa3
ToppCell	facs-MAT-Fat-3m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 CD68 SIGLEC1 CLEC10A NFAM1	6.75e-06	163	72	5	5fc836444bc156c8248abee001b0ecbe43f980c9
ToppCell	frontal_cortex-Non-neuronal-macrophage\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SELPLG RNASE4 CD68 TMEM119 NFAM1	6.75e-06	163	72	5	b89f586b444f90047c8ce407f53847fd1ee7cca3
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSPAN15 AMHR2 KREMEN2 CDH1 TNFRSF4	6.75e-06	163	72	5	56b8668dbf06faa6866ec71f29b92907b73f074d
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SELPLG RNASE4 CD68 TMEM119 NFAM1	6.75e-06	163	72	5	cbe9b4c4b2e42e9f92a57ed66758af93434db5bb
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	6.95e-06	164	72	5	8d089844896e84935eab705ebe54f125c4b6d9ca
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	6.95e-06	164	72	5	17fb1421476ba44999b1165f2576514f74c1f882
ToppCell	facs-SCAT-Fat-3m-Myeloid-myeloid_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	7.37e-06	166	72	5	8395c74db8e4e54af97a3f2b75cb75171140ec31
ToppCell	facs-SCAT-Fat-3m-Myeloid\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	7.37e-06	166	72	5	76807edc5620514b53a14be354b84c54c112b8f9
ToppCell	facs-SCAT-Fat-3m-Myeloid-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	7.37e-06	166	72	5	645b842b94b8d2f4b26c2623f8589f56bd782c26
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_T_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	FLT3LG CD6 LTBP3 SEZ6L2 FCMR	7.59e-06	167	72	5	78d264af390bd89942ffbb2991dc94f50756d4c9
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG NPHS1 BRI3BP NRXN2 LTA	7.59e-06	167	72	5	1248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	7.59e-06	167	72	5	7f9eedf68a800159c5642e04dd9569ae58109bd5
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG NPHS1 BRI3BP NRXN2 LTA	7.59e-06	167	72	5	a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCell	facs-Heart-RV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	7.82e-06	168	72	5	8ee57814c7e9d45444f48b6b269c4d535bc4d5e1
ToppCell	facs-Heart-RV-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG CD68 SIGLEC1 CLEC10A NFAM1	7.82e-06	168	72	5	c1a5f4f4d32a1f8583048db709a7037cc9357ad8
Drug	HhAntag691	PTCH2 SMO PTCH1 CDH1	3.25e-07	19	71	4	ctd:C538724
Disease	BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1	PTCH2 SMO PTCH1	4.27e-08	4	66	3	605462
Disease	Basal cell carcinoma, susceptibility to, 1	PTCH2 SMO PTCH1	4.27e-08	4	66	3	cv:C2751544
Disease	basal cell carcinoma (is_implicated_in)	PTCH2 SMO PTCH1	2.32e-06	12	66	3	DOID:2513 (is_implicated_in)
Disease	EPIDERMODYSPLASIA VERRUCIFORMIS, SUSCEPTIBILITY TO, 1	TMC6 TMC8	4.93e-06	2	66	2	C4722564
Disease	nevoid basal cell carcinoma syndrome (is_marker_for)	SMO PTCH1	1.48e-05	3	66	2	DOID:2512 (is_marker_for)
Disease	transmembrane protein 132A measurement	CD6 TMEM109	2.95e-05	4	66	2	EFO_0802150
Disease	dysgerminoma (is_marker_for)	AMHR2 ST14	2.95e-05	4	66	2	DOID:4441 (is_marker_for)
Disease	Oculo-dento-digital syndrome	PTCH2 PTCH1	2.95e-05	4	66	2	C0812437
Disease	Pigmented Basal Cell Carcinoma	PTCH2 SMO PTCH1	3.36e-05	28	66	3	C1368275
Disease	Carcinoma, Basal Cell	PTCH2 SMO PTCH1	3.75e-05	29	66	3	C4721806
Disease	epidermodysplasia verruciformis (is_implicated_in)	TMC6 TMC8	4.91e-05	5	66	2	DOID:13777 (is_implicated_in)
Disease	Epidermodysplasia Verruciformis	TMC6 TMC8	4.91e-05	5	66	2	C0014522
Disease	Basal Cell Nevus Syndrome	PTCH2 PTCH1	4.91e-05	5	66	2	C0004779
Disease	endometrial cancer (is_implicated_in)	COMT LTA CDH1	7.24e-05	36	66	3	DOID:1380 (is_implicated_in)
Disease	HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1	COMT RET	7.35e-05	6	66	2	C3888239
Disease	P-selectin glycoprotein ligand 1 measurement	SELPLG TMEM119	1.37e-04	8	66	2	EFO_0010922
Disease	Cerebral Primitive Neuroectodermal Tumor	SMO PTCH1	1.37e-04	8	66	2	C0751675
Disease	Spongioblastoma	SMO PTCH1	1.37e-04	8	66	2	C0334584
Disease	Ependymoblastoma	SMO PTCH1	1.37e-04	8	66	2	C0700367
Disease	Medulloepithelioma	SMO PTCH1	1.37e-04	8	66	2	C0334596
Disease	basal cell carcinoma (is_marker_for)	SMO PTCH1	1.37e-04	8	66	2	DOID:2513 (is_marker_for)
Disease	Neuroectodermal Tumor, Primitive	SMO PTCH1	1.37e-04	8	66	2	C0206663
Disease	Gastrointestinal Stromal Sarcoma	PTCH2 SMO PTCH1	1.62e-04	47	66	3	C3179349
Disease	Medulloblastoma	PTCH2 SMO PTCH1	1.94e-04	50	66	3	C0025149
Disease	Gastrointestinal Stromal Tumors	PTCH2 SMO PTCH1	1.94e-04	50	66	3	C0238198
Disease	Basal cell carcinoma	SMO PTCH1	2.68e-04	11	66	2	C0007117
Disease	breast cancer (is_implicated_in)	COMT LTA CDH1 BIK	3.62e-04	150	66	4	DOID:1612 (is_implicated_in)
Disease	Craniofacial Abnormalities	FZD4 LTBP3 PTCH1 GPC6	4.20e-04	156	66	4	C0376634
Disease	Arthritis, Psoriatic	CD68 LTA	4.41e-04	14	66	2	C0003872
Disease	hepatoblastoma (is_marker_for)	SMO CDH1	5.08e-04	15	66	2	DOID:687 (is_marker_for)
Disease	Pheochromocytoma, Extra-Adrenal	COMT RET	5.79e-04	16	66	2	C1257877
Disease	methylcobalamin deficiency type cblE	TSPAN15 RNASE4 SEZ6L2	6.19e-04	74	66	3	MONDO_0009354
Disease	Pheochromocytoma	COMT RET	8.22e-04	19	66	2	C0031511
Disease	response to methotrexate, neurotoxicity	ZDHHC19 GPC6	8.22e-04	19	66	2	EFO_0011057, GO_0031427
Disease	Osteoarthritis of hip	SMO LTBP3	9.12e-04	20	66	2	C0029410
Disease	carotid artery disease (is_implicated_in)	SELPLG LTA	1.11e-03	22	66	2	DOID:3407 (is_implicated_in)
Disease	pancreatic cancer (is_marker_for)	SMO RET PTCH1	1.52e-03	101	66	3	DOID:1793 (is_marker_for)
Disease	Subfertility, Female	CACNA2D2 SMO	1.79e-03	28	66	2	C0341869
Disease	prostate carcinoma in situ (is_marker_for)	FZD4 ST14	1.79e-03	28	66	2	DOID:8634 (is_marker_for)
Disease	Sterility, Postpartum	CACNA2D2 SMO	1.79e-03	28	66	2	C0038279
Disease	Female sterility	CACNA2D2 SMO	1.79e-03	28	66	2	C0917730
Disease	Female infertility	CACNA2D2 SMO	1.79e-03	28	66	2	C0021361
Disease	urinary metabolite measurement	NPHS1 COMT BRI3BP NAT8	2.23e-03	245	66	4	EFO_0005116

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVRGSLLLLALLILV	ERVK13-1	456	Q9NX77
LLLLLLLLLLGLLAP	BRI3BP	16	Q8WY22
GVLVSLQLLLLLGLP	CACNA2D2	1121	Q9NY47
LLPLSLLALLALLGG	ADGRA3	16	Q8IWK6
GLLLLLLLLLTQPGA	CD93	6	Q9NPY3
LLLSLGLLAGLLPAL	CHAD	6	O15335
LLLLALLLPLLSGGL	BIK	141	Q13323
LLGLFLLLLLLLGSI	AMHR2	151	Q16671
PVLGLLLLLLLSVLL	KASH5	526	Q8N6L0
LLPLIIGLILLGLLA	CD68	321	P34810
LLIPSIVLGILLLGS	CD6	401	P30203
LGPAAIGLLLLGLLL	DSG3	616	P32926
IGLLLLGLLLLLLAP	DSG3	621	P32926
PLLPVLFALGGLLLL	NPHS1	1061	O60500
LLLPLLLLLLLLLGA	DCHS1	21	Q96JQ0
VPGPLLGLLLLLLGV	IL17RA	11	Q96F46
ITGLAGPLLILLLSL	ERVS71-1	576	P61550
ILITSLIGGGLLILI	IL31RA	521	Q8NI17
LGLTVLPALLQLVLL	SLC2A4	206	P14672
LLLLLLLPVGLLLLA	FLT3LG	186	P49771
VSVLLLLLLGLLRPL	KREMEN2	376	Q8NCW0
GVLLSLIHLVLLLPL	OR2A7	151	Q96R45
LGPSALGLLLLLLVV	PRSS38	11	A1L453
GVLLSLIHLVLLLPL	OR2A4	151	O95047
LLGLSLVGLLLYLVP	POM121C	36	A8CG34
LLPLLLLLLLGAAEG	NRXN2	36	P58401
LLLGLRLQLSLGIIP	ALPP	11	P05187
VLLLLGLRLQLSLGI	ALPG	6	P10696
LLGLSLVGLLLYLVP	POM121	36	Q96HA1
PLLLAAVLLGLVLLV	COMT	6	P21964
GVGLSLGLLLQLLLL	FZD4	16	Q9ULV1
LGLLLQLLLLLGPAR	FZD4	21	Q9ULV1
LFLPLLLLLGELQAL	SLC35C1	241	Q96A29
GAVILPLLGLLLSLP	GPC6	6	Q9Y625
LLLLLTLLLPGLGIF	ERN1	6	O75460
LLLLLLLLLLGLGGR	LTBP3	26	Q9NS15
VLALLLPVLLLVGLS	LYPD5	236	Q6UWN5
LGILGGILALLILIL	CDH1	711	P12830
LLLLILLGPGNSLQL	SELPLG	6	Q14242
LQVLLTLPLLFLGLS	TMEM191B	286	P0C7N4
ALQVLLTLPLLFLGL	TMEM191C	286	A6NGB0
LLLGVLLLPGTLRLA	NFAM1	26	Q8NET5
TLLGLLHGLVLLPVL	PTCH2	1096	Q9Y6C5
ILGVLNGLVLLPVLL	PTCH1	1161	Q13635
GLILGVGLLLLLVSI	SMIM35	11	A0A1B0GVV1
ALAILLPLGLVIVLG	SEZ6L2	846	Q6UXD5
LVGVLGGLLLLTILV	ITGA2B	1001	P08514
VILLGLLVPALGLLF	SLC10A5	336	Q5PT55
LPTFLLTLLGNLLII	OR6J1	31	Q8NGC5
LLSSLLGLLLLGLLL	OS9	6	Q13438
LGLLLLGLLLPASLT	OS9	11	Q13438
AIIIIGLGFLLLLLP	SLC35F3	361	Q8IY50
LLLSLGLGLLLLVII	CLEC10A	41	Q8IUN9
LLLLLTLLGLGLVQP	RNASE4	11	P34096
TLHLLLLGLLLVLLP	LTA	16	P01374
LLGLLLVLLPGAQGL	LTA	21	P01374
LVLLLGLLLAAVPLG	TMC8	536	Q8IU68
LTGPLVSLLLLLLFG	ERVFRD-1	486	P60508
VLIGLLLVLLGIGFL	ST14	61	Q9Y5Y6
GILLGILLPQFLGVL	TSPAN15	236	O95858
IPTILGLFLLALLGL	FCMR	256	O60667
LLGLIGGLTLLLLLT	TEX264	6	Q9Y6I9
LLVTGFLLLVPLLVL	TMEM88	91	Q6PEY1
LGLLVGLLLLLLGLG	SIGLEC1	1646	Q9BZZ2
ELPLLGLLLLLLLGD	SMO	11	Q99835
LLLLPLLGKVALGLY	RET	16	P07949
LGLVLGLLGPLAILL	TNFRSF4	221	P43489
GLLGPLAILLALYLL	TNFRSF4	226	P43489
SLLLGLVLALLGRIL	TMEM109	146	Q9BVC6
TLGLLGQLIIRLLPA	ZZEF1	2136	O43149
AAGLLVPLSLLLLIQ	ZDHHC19	201	Q8WVZ1
VLLVLPLVVGLLNLG	TMC6	471	Q7Z403
SGLEIGSLLLPLLLL	TMUB1	191	Q9BVT8
APSLLILLLLLLGSV	TMEM119	6	Q4V9L6
STLLGILLPLLLLVA	MST1R	956	Q04912
LLQRAGLLLLLGLLG	ZFPL1	261	O95159
RTLILLLGGPLALLL	NAT8	41	Q9UHE5
VIGGVLGVVLLLLLL	MPZ	161	P25189