Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM49 TRIM51 RNF103 WWP2 TRIM49C TRIM49D1 TRIM21 HECTD1 TRIM49B	6.60e-06	372	71	9	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM49 TRIM51 RNF103 WWP2 TRIM49C TRIM49D1 TRIM21 HECTD1 TRIM49B	1.13e-05	398	71	9	GO:0061659
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX1 DUOX2	1.25e-05	2	71	2	GO:0106293
GeneOntologyMolecularFunction	acyltransferase activity	TRIM49 TRIM51 RNF103 WWP2 GGTLC1 TRIM49C HGSNAT TRIM49D1 TRIM21 CPT1B HECTD1 TRIM49B	1.67e-05	775	71	12	GO:0016746
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRIM49 TRIM51 RNF103 WWP2 GGTLC1 TRIM49C TRIM49D1 TRIM21 HECTD1 TRIM49B	1.78e-05	532	71	10	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRIM49 TRIM51 RNF103 WWP2 TRIM49C TRIM49D1 TRIM21 HECTD1 TRIM49B	4.41e-05	473	71	9	GO:0004842
GeneOntologyMolecularFunction	zinc ion binding	TRIM49 TRIM51 P2RX4 TRIM49C TRIM49D1 ZMYM2 CPXM1 CPA3 TRIM21 KDM1B ZCCHC2 TRIM49B	6.53e-05	891	71	12	GO:0008270
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRIM49 TRIM51 RNF103 WWP2 TRIM49C TRIM49D1 TRIM21 HECTD1 TRIM49B	8.10e-05	512	71	9	GO:0019787
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX1 DUOX2	1.24e-04	5	71	2	GO:0106294
GeneOntologyMolecularFunction	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN5A SCN10A	1.85e-04	6	71	2	GO:0086006
GeneOntologyMolecularFunction	monoatomic cation channel activity	PKD2L2 P2RX4 BEST2 SCN5A SCN10A HVCN1 CNGB1	2.15e-04	343	71	7	GO:0005261
GeneOntologyMolecularFunction	protein kinase binding	TRIM49 PLK2 ANGPT2 TRIM51 PSG5 SCN5A TRIM49C TRIM21 DNM1 TRIM49B IQGAP1	2.43e-04	873	71	11	GO:0019901
GeneOntologyMolecularFunction	transition metal ion binding	TRIM49 AOC1 TRIM51 P2RX4 TRIM49C TRIM49D1 ZMYM2 CPXM1 CPA3 TRIM21 KDM1B ZCCHC2 TRIM49B	2.54e-04	1189	71	13	GO:0046914
GeneOntologyMolecularFunction	kinase binding	TRIM49 PLK2 ANGPT2 TRIM51 PSG5 SCN5A TRIM49C TRIM21 DNM1 TRIM49B IQGAP1	5.88e-04	969	71	11	GO:0019900
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	DUOX1 DUOX2	8.04e-04	12	71	2	GO:0016174
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	DUOX1 DUOX2	8.04e-04	12	71	2	GO:0016175
GeneOntologyMolecularFunction	sodium channel activity	SCN5A SCN10A CNGB1	8.40e-04	52	71	3	GO:0005272
GeneOntologyMolecularFunction	monoatomic ion channel activity	PKD2L2 P2RX4 BEST2 SCN5A SCN10A HVCN1 CNGB1	1.21e-03	459	71	7	GO:0005216
GeneOntologyMolecularFunction	peroxidase activity	DUOX1 IPCEF1 DUOX2	1.61e-03	65	71	3	GO:0004601
GeneOntologyMolecularFunction	oxidoreductase activity, acting on peroxide as acceptor	DUOX1 IPCEF1 DUOX2	1.75e-03	67	71	3	GO:0016684
GeneOntologyMolecularFunction	transporter activity	CLPTM1L OSBP PKD2L2 P2RX4 PSG5 SLC25A39 BEST2 SCN5A SCN10A CYB561D1 HVCN1 CNGB1	1.84e-03	1289	71	12	GO:0005215
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	DUOX1 DUOX2	2.27e-03	20	71	2	GO:0050664
GeneOntologyMolecularFunction	channel activity	PKD2L2 P2RX4 BEST2 SCN5A SCN10A HVCN1 CNGB1	2.60e-03	525	71	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	PKD2L2 P2RX4 BEST2 SCN5A SCN10A HVCN1 CNGB1	2.62e-03	526	71	7	GO:0022803
GeneOntologyMolecularFunction	nitric-oxide synthase binding	SCN5A DNM1	2.75e-03	22	71	2	GO:0050998
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN5A SCN10A	3.83e-03	26	71	2	GO:0005248
GeneOntologyMolecularFunction	antioxidant activity	DUOX1 IPCEF1 DUOX2	5.00e-03	97	71	3	GO:0016209
GeneOntologyMolecularFunction	phosphatidylinositol binding	OSBP PSG5 ZCCHC2 DNM1 IQGAP1	5.34e-03	316	71	5	GO:0035091
GeneOntologyMolecularFunction	metallocarboxypeptidase activity	CPXM1 CPA3	5.42e-03	31	71	2	GO:0004181
GeneOntologyCellularComponent	clathrin-coated pit	VLDLR CLTCL1 DNM1 SH3BP4	1.77e-04	80	73	4	GO:0005905
Domain	BBOX	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	2.63e-07	69	72	6	SM00336
Domain	Butyrophylin	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	2.86e-07	70	72	6	IPR003879
Domain	-	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	3.12e-07	71	72	6	4.10.45.10
Domain	zf-B_box	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	3.39e-07	72	72	6	PF00643
Domain	ZF_BBOX	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	6.37e-07	80	72	6	PS50119
Domain	Znf_B-box	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	6.86e-07	81	72	6	IPR000315
Domain	SPRY	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.65e-06	94	72	6	PF00622
Domain	SPRY_dom	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.65e-06	94	72	6	IPR003877
Domain	B30.2/SPRY	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.76e-06	95	72	6	IPR001870
Domain	B302_SPRY	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.76e-06	95	72	6	PS50188
Domain	DUOX1	DUOX1 DUOX2	1.47e-05	2	72	2	IPR029595
Domain	ConA-like_dom	TRIM49 COL12A1 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	2.14e-05	219	72	7	IPR013320
Domain	SPRY	TRIM49 TRIM49C TRIM49D1 TRIM21 TRIM49B	2.14e-05	87	72	5	SM00449
Domain	ZF_RING_2	TRIM49 TRIM51 RNF103 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.49e-04	298	72	7	PS50089
Domain	RING	TRIM49 TRIM51 RNF103 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.72e-04	305	72	7	SM00184
Domain	Znf_RING	TRIM49 TRIM51 RNF103 TRIM49C TRIM49D1 TRIM21 TRIM49B	2.58e-04	326	72	7	IPR001841
Domain	NAD_binding_6	DUOX1 DUOX2	3.04e-04	7	72	2	PF08030
Domain	FAD_binding_8	DUOX1 DUOX2	3.04e-04	7	72	2	PF08022
Domain	FAD-bd_8	DUOX1 DUOX2	3.04e-04	7	72	2	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX1 DUOX2	3.04e-04	7	72	2	IPR013121
Domain	IQ_motif_EF-hand-BS	SCN5A SCN10A MYO18A IQGAP1	4.04e-04	90	72	4	IPR000048
Domain	-	VLDLR TENM1 ROS1	4.54e-04	39	72	3	2.120.10.30
Domain	IQ	SCN5A SCN10A MYO18A IQGAP1	4.58e-04	93	72	4	PS50096
Domain	Na_channel_asu	SCN5A SCN10A	6.46e-04	10	72	2	IPR001696
Domain	Haem_peroxidase	DUOX1 DUOX2	6.46e-04	10	72	2	IPR010255
Domain	An_peroxidase	DUOX1 DUOX2	6.46e-04	10	72	2	PF03098
Domain	Na_trans_assoc	SCN5A SCN10A	6.46e-04	10	72	2	IPR010526
Domain	PEROXIDASE_3	DUOX1 DUOX2	6.46e-04	10	72	2	PS50292
Domain	Haem_peroxidase_animal	DUOX1 DUOX2	6.46e-04	10	72	2	IPR019791
Domain	-	DUOX1 DUOX2	6.46e-04	10	72	2	1.10.640.10
Domain	Na_trans_assoc	SCN5A SCN10A	6.46e-04	10	72	2	PF06512
Domain	Ldl_recept_a	DGCR2 VLDLR TMPRSS4	6.94e-04	45	72	3	PF00057
Domain	-	DGCR2 VLDLR TMPRSS4	7.40e-04	46	72	3	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	VLDLR TENM1 ROS1	7.40e-04	46	72	3	IPR011042
Domain	LDLRA_1	DGCR2 VLDLR TMPRSS4	8.39e-04	48	72	3	PS01209
Domain	LDLRA_2	DGCR2 VLDLR TMPRSS4	8.91e-04	49	72	3	PS50068
Domain	LDrepeatLR_classA_rpt	DGCR2 VLDLR TMPRSS4	8.91e-04	49	72	3	IPR002172
Domain	LDLa	DGCR2 VLDLR TMPRSS4	8.91e-04	49	72	3	SM00192
Domain	ZF_RING_1	TRIM49 TRIM51 RNF103 TRIM49C TRIM21 TRIM49B	8.97e-04	291	72	6	PS00518
Domain	Ferric_reduct	DUOX1 DUOX2	9.43e-04	12	72	2	PF01794
Domain	Fe3_Rdtase_TM_dom	DUOX1 DUOX2	9.43e-04	12	72	2	IPR013130
Domain	Ion_trans_dom	SCN5A SCN10A HVCN1 CNGB1	9.84e-04	114	72	4	IPR005821
Domain	Ion_trans	SCN5A SCN10A HVCN1 CNGB1	9.84e-04	114	72	4	PF00520
Domain	Channel_four-helix_dom	SCN5A SCN10A HVCN1	1.38e-03	57	72	3	IPR027359
Domain	-	SCN5A SCN10A HVCN1	1.38e-03	57	72	3	1.20.120.350
Domain	LY	VLDLR ROS1	1.49e-03	15	72	2	SM00135
Domain	LDLR_classB_rpt	VLDLR ROS1	1.49e-03	15	72	2	IPR000033
Domain	EGF_extracell	TIE1 ADAM18 TENM1	1.61e-03	60	72	3	IPR013111
Domain	EGF_2	TIE1 ADAM18 TENM1	1.61e-03	60	72	3	PF07974
Domain	-	TRIM49 TRIM51 RNF103 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.70e-03	449	72	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TRIM49 TRIM51 RNF103 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.92e-03	459	72	7	IPR013083
Domain	Zn_pept	CPXM1 CPA3	2.15e-03	18	72	2	SM00631
Domain	Fd_Rdtase_FAD-bd	DUOX1 DUOX2	2.40e-03	19	72	2	IPR017927
Domain	FAD_FR	DUOX1 DUOX2	2.40e-03	19	72	2	PS51384
Domain	CARBOXYPEPT_ZN_2	CPXM1 CPA3	2.40e-03	19	72	2	PS00133
Domain	Myosin-like_IQ_dom	MYO18A IQGAP1	2.40e-03	19	72	2	IPR027401
Domain	-	MYO18A IQGAP1	2.40e-03	19	72	2	4.10.270.10
Domain	Riboflavin_synthase-like_b-brl	DUOX1 DUOX2	2.40e-03	19	72	2	IPR017938
Domain	IQ	SCN10A MYO18A IQGAP1	2.60e-03	71	72	3	PF00612
Domain	CARBOXYPEPT_ZN_1	CPXM1 CPA3	2.66e-03	20	72	2	PS00132
Domain	Peptidase_M14	CPXM1 CPA3	3.52e-03	23	72	2	PF00246
Domain	Peptidase_M14	CPXM1 CPA3	3.52e-03	23	72	2	IPR000834
Domain	IQ	SCN5A MYO18A IQGAP1	3.78e-03	81	72	3	SM00015
Domain	Fibrinogen_a/b/g_C_2	MFAP4 ANGPT2	3.83e-03	24	72	2	IPR014715
Domain	-	MFAP4 ANGPT2	3.83e-03	24	72	2	4.10.530.10
Domain	Rho_GTPase_activation_prot	ARHGAP29 OPHN1 IQGAP1	4.77e-03	88	72	3	IPR008936
Domain	HECT	WWP2 HECTD1	4.83e-03	27	72	2	PF00632
Domain	HECTc	WWP2 HECTD1	4.83e-03	27	72	2	SM00119
Domain	HECT_dom	WWP2 HECTD1	4.83e-03	27	72	2	IPR000569
Domain	HECT	WWP2 HECTD1	4.83e-03	27	72	2	PS50237
Domain	Fibrinogen_C	MFAP4 ANGPT2	4.83e-03	27	72	2	PF00147
Domain	FBG	MFAP4 ANGPT2	5.56e-03	29	72	2	SM00186
Domain	FN3	IL10RB COL12A1 TIE1 ROS1	5.68e-03	185	72	4	SM00060
Domain	-	MFAP4 ANGPT2	5.95e-03	30	72	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	MFAP4 ANGPT2	5.95e-03	30	72	2	IPR014716
Domain	FIBRINOGEN_C_1	MFAP4 ANGPT2	6.75e-03	32	72	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	MFAP4 ANGPT2	6.75e-03	32	72	2	IPR002181
Domain	FIBRINOGEN_C_2	MFAP4 ANGPT2	6.75e-03	32	72	2	PS51406
Domain	FN3	IL10RB COL12A1 TIE1 ROS1	7.32e-03	199	72	4	PS50853
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B	4.03e-10	19	73	5	22144910
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM49 TRIM51 TRIM49C TRIM49B	2.40e-08	15	73	4	19703589
Pubmed	A common genetic variant within SCN10A modulates cardiac SCN5A expression.	SCN5A SCN10A	4.35e-06	2	73	2	24642470
Pubmed	Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.	DUOX1 DUOX2	4.35e-06	2	73	2	28633507
Pubmed	Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.	DUOX1 DUOX2	4.35e-06	2	73	2	30375286
Pubmed	HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures.	HECTD1 IQGAP1	4.35e-06	2	73	2	28073378
Pubmed	Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.	DUOX1 DUOX2	4.35e-06	2	73	2	10806195
Pubmed	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.	DUOX1 DUOX2	4.35e-06	2	73	2	11514595
Pubmed	Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.	DUOX1 DUOX2	4.35e-06	2	73	2	24161126
Pubmed	Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.	DUOX1 DUOX2	4.35e-06	2	73	2	22523549
Pubmed	Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.	SCN5A SCN10A	4.35e-06	2	73	2	15047701
Pubmed	Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis.	DUOX1 DUOX2	4.35e-06	2	73	2	23281318
Pubmed	Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.	DUOX1 DUOX2	4.35e-06	2	73	2	31706280
Pubmed	Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.	DUOX1 DUOX2	4.35e-06	2	73	2	11443211
Pubmed	Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.	DUOX1 DUOX2	4.35e-06	2	73	2	10601291
Pubmed	Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.	SCN5A SCN10A	4.35e-06	2	73	2	31292628
Pubmed	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.	DUOX1 DUOX2	4.35e-06	2	73	2	15972824
Pubmed	The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.	DUOX1 DUOX2	4.35e-06	2	73	2	25586178
Pubmed	Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.	DUOX1 DUOX2	4.35e-06	2	73	2	23362256
Pubmed	Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.	DUOX1 DUOX2	4.35e-06	2	73	2	19144650
Pubmed	Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.	DUOX1 DUOX2	4.35e-06	2	73	2	16111680
Pubmed	Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.	DUOX1 DUOX2	4.35e-06	2	73	2	11762710
Pubmed	Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.	DUOX1 DUOX2	4.35e-06	2	73	2	11822874
Pubmed	Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.	DUOX1 DUOX2	4.35e-06	2	73	2	11753072
Pubmed	Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.	DUOX1 DUOX2	4.35e-06	2	73	2	18281478
Pubmed	Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.	DUOX1 DUOX2	4.35e-06	2	73	2	15062544
Pubmed	Regulated hydrogen peroxide production by Duox in human airway epithelial cells.	DUOX1 DUOX2	4.35e-06	2	73	2	15677770
Pubmed	Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.	SCN5A SCN10A	4.35e-06	2	73	2	24998131
Pubmed	Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.	DUOX1 DUOX2	4.35e-06	2	73	2	18177232
Pubmed	Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.	DUOX1 DUOX2	4.35e-06	2	73	2	24128054
Pubmed	From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.	SCN5A SCN10A	4.35e-06	2	73	2	24360055
Pubmed	Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.	DUOX1 DUOX2	4.35e-06	2	73	2	12824283
Pubmed	Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.	SCN5A SCN10A	4.35e-06	2	73	2	32330377
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	TRIM49 TRIM51 TRIM49C TRIM49B	5.62e-06	55	73	4	19468303
Pubmed	Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.	ANGPT2 TIE1	1.30e-05	3	73	2	22342979
Pubmed	NADPH oxidase-dependent acid production in airway epithelial cells.	DUOX1 DUOX2	1.30e-05	3	73	2	15210697
Pubmed	The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.	DNM1 OPHN1	1.30e-05	3	73	2	19481455
Pubmed	Role of nicotinamide adenine dinucleotide phosphate oxidase in mediating vesicant-induced interleukin-6 secretion in human airway epithelial cells.	DUOX1 DUOX2	1.30e-05	3	73	2	24164541
Pubmed	DUOX enzyme activity promotes AKT signalling in prostate cancer cells.	DUOX1 DUOX2	1.30e-05	3	73	2	23225414
Pubmed	NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.	DUOX1 DUOX2	1.30e-05	3	73	2	21915726
Pubmed	A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice.	P2RX4 HVCN1	1.30e-05	3	73	2	33336163
Pubmed	Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation.	OSBP IQGAP1	1.30e-05	3	73	2	26473364
Pubmed	Tie1 controls angiopoietin function in vascular remodeling and inflammation.	ANGPT2 TIE1	1.30e-05	3	73	2	27548530
Pubmed	Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch.	ANGPT2 WNT7B	1.30e-05	3	73	2	18039971
Pubmed	Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.	DUOX1 DUOX2	1.30e-05	3	73	2	19952225
Pubmed	High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.	SCN5A SCN10A	1.30e-05	3	73	2	25998140
Pubmed	Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation.	ANGPT2 TIE1 WNT7B	2.23e-05	26	73	3	20978081
Pubmed	Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.	DUOX1 DUOX2	2.60e-05	4	73	2	27110716
Pubmed	Genetic variation in SCN10A influences cardiac conduction.	AOC1 SCN10A	2.60e-05	4	73	2	20062061
Pubmed	The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta.	ANGPT2 TIE1	2.60e-05	4	73	2	18675456
Pubmed	Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners.	OSBP SUGT1	2.60e-05	4	73	2	21566117
Pubmed	Genome-wide association studies of the PR interval in African Americans.	SCN5A SCN10A	2.60e-05	4	73	2	21347284
Pubmed	Signaling and functions of angiopoietin-1 in vascular protection.	ANGPT2 TIE1	2.60e-05	4	73	2	16645151
Pubmed	The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.	DUOX1 DUOX2	2.60e-05	4	73	2	22814254
Pubmed	Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.	DUOX1 DUOX2	2.60e-05	4	73	2	19339556
Pubmed	Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.	SCN5A SCN10A	4.33e-05	5	73	2	22706305
Pubmed	Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.	SCN5A SCN10A	4.33e-05	5	73	2	23463857
Pubmed	Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.	SCN5A SCN10A	4.33e-05	5	73	2	23872634
Pubmed	Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.	DUOX1 DUOX2	4.33e-05	5	73	2	15561711
Pubmed	Expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma.	ANGPT2 TIE1	4.33e-05	5	73	2	17724803
Pubmed	Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.	WWP2 SCN5A	4.33e-05	5	73	2	15548568
Pubmed	Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide.	DUOX1 DUOX2	4.33e-05	5	73	2	16478776
Pubmed	Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.	DUOX1 DUOX2	4.33e-05	5	73	2	34784249
Pubmed	Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta.	DUOX1 DUOX2	6.48e-05	6	73	2	12671064
Pubmed	Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.	DUOX1 DUOX2	6.48e-05	6	73	2	17332529
Pubmed	APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.	DUOX1 DUOX2	6.48e-05	6	73	2	28165467
Pubmed	Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation.	ANGPT2 TIE1	6.48e-05	6	73	2	10446940
Pubmed	TTP specifically regulates the internalization of the transferrin receptor.	DNM1 SH3BP4	6.48e-05	6	73	2	16325581
Pubmed	Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.	SCN5A SCN10A	9.06e-05	7	73	2	23139255
Pubmed	Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.	DUOX1 DUOX2	9.06e-05	7	73	2	19005069
Pubmed	Genetic analysis of intestinal cholesterol absorption in inbred mice.	VLDLR OSBP	9.06e-05	7	73	2	11714849
Pubmed	A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11.	DGCR2 CLTCL1	1.21e-04	8	73	2	8776594
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN5A SCN10A	1.55e-04	9	73	2	16382098
Pubmed	Involvement of insulin-like growth factor 2 in angiogenic factor transcription in Bi-maternal mouse conceptuses.	ANGPT2 TIE1	1.55e-04	9	73	2	19881219
Pubmed	Genetic dissection of tie pathway in mouse lymphatic maturation and valve development.	ANGPT2 TIE1	1.55e-04	9	73	2	24764452
Pubmed	Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta.	ANGPT2 TIE1	1.93e-04	10	73	2	18477666
Pubmed	Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.	ANGPT2 TIE1	1.93e-04	10	73	2	10323857
Pubmed	ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression.	ANGPT2 TIE1	1.93e-04	10	73	2	12221099
Pubmed	Genetic polymorphisms and susceptibility to lung disease.	DUOX1 DUOX2	1.93e-04	10	73	2	16608528
Pubmed	Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO.	DUOX1 DUOX2	2.36e-04	11	73	2	30755476
Pubmed	Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.	ANGPT2 TIE1	2.36e-04	11	73	2	16234353
Pubmed	Genome-wide association study of PR interval.	SCN5A SCN10A	2.83e-04	12	73	2	20062060
Pubmed	Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis.	ANGPT2 TIE1	3.34e-04	13	73	2	28835631
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN5A SCN10A	3.34e-04	13	73	2	15123669
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	MFAP4 COL12A1 CLTCL1 UFSP2 SUGT1 JAGN1 TMPRSS4 TRIM21 HVCN1 OPHN1	3.60e-04	1293	73	10	15342556
Pubmed	Several common variants modulate heart rate, PR interval and QRS duration.	SCN5A SCN10A	3.89e-04	14	73	2	20062063
Pubmed	Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.	CLPTM1L RGS22	3.89e-04	14	73	2	24403052
Pubmed	Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.	PLK2 DNM1	3.89e-04	14	73	2	20802490
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	WWP2 ZMYM2	3.89e-04	14	73	2	26147758
Pubmed	Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.	ANGPT2 TIE1	4.48e-04	15	73	2	10051567
Pubmed	Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.	ANGPT2 TIE1	4.48e-04	15	73	2	11032855
Pubmed	Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.	SCN5A SCN10A	5.12e-04	16	73	2	25035420
Pubmed	Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.	ANGPT2 TIE1	5.12e-04	16	73	2	28179430
Pubmed	Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.	SCN5A SCN10A	5.79e-04	17	73	2	21076409
Pubmed	Genetic determinants of P wave duration and PR segment.	SCN5A SCN10A	5.79e-04	17	73	2	24850809
Pubmed	Human chromosome 11 DNA sequence and analysis including novel gene identification.	TRIM49 TRIM49C TRIM49D1	6.49e-04	80	73	3	16554811
Pubmed	Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development.	ANGPT2 TIE1	6.51e-04	18	73	2	16514057
Pubmed	Transcript profiling during preimplantation mouse development.	RNF103 PSG5	6.51e-04	18	73	2	15282163
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN5A SCN10A	6.51e-04	18	73	2	31666509
Pubmed	Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects.	ANGPT2 TIE1	6.51e-04	18	73	2	12093914
Cytoband	15q15.3	DUOX1 DUOX2	7.31e-04	25	73	2	15q15.3
Cytoband	11q14.3	TRIM49C TRIM49D1	1.20e-03	32	73	2	11q14.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11q14	TRIM49 TRIM49C TRIM49D1	2.01e-03	156	73	3	chr11q14
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM21 TRIM49B	3.37e-07	95	53	6	59
GeneFamily	Ring finger proteins	TRIM49 TRIM51 RNF103 TRIM49C TRIM49D1 TRIM21 TRIM49B	1.48e-05	275	53	7	58
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN5A SCN10A	3.00e-04	9	53	2	1203
GeneFamily	Carboxypeptidases	CPXM1 CPA3	1.71e-03	21	53	2	1321
GeneFamily	Fibrinogen C domain containing	MFAP4 ANGPT2	2.42e-03	25	53	2	554
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TIE1 ROS1	6.12e-03	40	53	2	321
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	VLDLR ANGPT2 TIE1 CYB561D1 CPXM1 DNM1	2.57e-07	160	73	6	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	mild-Others-CD34+_GATA2+_cells\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MFAP4 ANGPT2 TIE1 CPXM1 DUOX2 CPA3	3.94e-07	172	73	6	379f6f271e653d5e404851e51a189bd582bb0f43
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BEST2 ANKAR SCN10A TENM1 ROS1	4.08e-06	145	73	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	390C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MFAP4 CLTCL1 WNT7B MYO18A TRIM21	5.14e-06	152	73	5	ebce79e106bf1d84241f8dd3496ff1771f9666be
ToppCell	390C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MFAP4 CLTCL1 WNT7B MYO18A TRIM21	5.14e-06	152	73	5	4a749d1b6d35fd55a8c42d7bd04b6ff5b11ce781
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKAR SCN10A TENM1 DUOX2 ROS1	7.01e-06	162	73	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ANGPT2 IPCEF1 RGS22 CPA3 TTLL7	8.61e-06	169	73	5	f68195510b91e287fe1507455ca067ece77a3897
ToppCell	COVID-19_Severe-NK_CD56bright\|COVID-19_Severe / Disease condition and Cell class	PLK2 KLRF1 TIE1 HVCN1 SH3BP4	9.12e-06	171	73	5	5810f790012a0750ca3378595514f66a99f123be
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 GVINP1 TIE1 ARHGAP29 TTLL7	1.08e-05	177	73	5	ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 GVINP1 TIE1 ARHGAP29 TTLL7	1.08e-05	177	73	5	f471f7747d6e8db7546899019af9508f48a14f89
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 GVINP1 TIE1 ARHGAP29 TTLL7	1.08e-05	177	73	5	cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCell	COVID-19_Mild-NK_CD56bright\|COVID-19_Mild / Disease condition and Cell class	PLK2 KLRF1 TIE1 HVCN1 SH3BP4	1.14e-05	179	73	5	90e7a4af195aa2332b07a9f06cde63e72ff49255
ToppCell	hematopoetic_progenitors-CD34+_MEP_2\|World / Lineage and Cell class	ANGPT2 TIE1 CPXM1 CPA3 TTLL7	1.23e-05	182	73	5	a7e7aa10f14111a6c7ba22e0f1668dcaa124714d
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLK2 RHBDL2 COL12A1 ANGPT2 TIE1	1.33e-05	185	73	5	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|Mesenchymal_cells / Lineage and Cell class	VLDLR RHBDL2 WWP2 WNT7B HVCN1	1.40e-05	187	73	5	e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RHBDL2 WNT7B TMPRSS4 DUOX2 FER1L6	1.56e-05	191	73	5	cd709bbcd320373468ea7f058ee5fda8a067b5d0
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RHBDL2 WNT7B TMPRSS4 DUOX2 FER1L6	1.56e-05	191	73	5	14851529025cfc2b665f71ebad04150ec543da7a
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RHBDL2 WNT7B TMPRSS4 DUOX2 FER1L6	1.56e-05	191	73	5	e14b22e882ac92acf8c8b6ee997ef8e799c7a8d5
ToppCell	BL-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RHBDL2 WNT7B TMPRSS4 DUOX2 FER1L6	1.85e-05	198	73	5	484d16aaa601a1e11b871b0475dd01a2de1a29ce
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MFAP4 COL12A1 ANGPT2 DUOX2 TTLL7	1.85e-05	198	73	5	77288df94286382170a266474ab85960519e8449
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MFAP4 COL12A1 ANGPT2 DUOX2 TTLL7	1.85e-05	198	73	5	2ee195f20a4f91fa1dcad9eaf96d6086e3b0fb4a
ToppCell	moderate-Epithelial-Secretory\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RHBDL2 WNT7B TMPRSS4 DUOX2 FER1L6	1.85e-05	198	73	5	7d96d7105a849c7280ce87bd76ce130ac47384fd
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	PLK2 RHBDL2 COL12A1 ANGPT2 TIE1	1.94e-05	200	73	5	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IPCEF1 TENM1 ARHGAP29 DNM1	8.98e-05	143	73	4	7a7a9829ba63468c9745904d9e993590051207ab
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MFAP4 ANGPT2 CPA3 TTLL7	1.05e-04	149	73	4	797b5f267e86fbe1d7af99df514d8074446603c6
ToppCell	TCGA-Lung\|World / Sample_Type by Project: Shred V9	CLPTM1L WNT7B GGTLC1 ROS1	1.08e-04	150	73	4	8c133206786e8f22bb70f2a7de9c0cb7f9ea9313
ToppCell	facs-Brain_Myeloid-Cerebellum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR CPA3 MS4A7 IQGAP1	1.26e-04	156	73	4	28c4fb4d2c6c47696c3a6722998f9da5a8923323
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MFAP4 COL12A1 ANGPT2 CPXM1	1.35e-04	159	73	4	cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell	10x5'-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	ANGPT2 DUOX2 CPA3 TTLL7	1.35e-04	159	73	4	c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	P2RX4 GVINP1 CPA3 CPT1B	1.39e-04	160	73	4	6393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCell	NS-critical-d_16-33-Myeloid-Mast_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TIE1 CPXM1 CPA3 DNM1	1.39e-04	160	73	4	c61869d9dbba250270e59366e15af204e5b4395d
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	P2RX4 GVINP1 CPA3 CPT1B	1.39e-04	160	73	4	2065938e944eb99478fd8132c2c03adeaee6d447
ToppCell	10x5'-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	ANGPT2 DUOX2 CPA3 TTLL7	1.42e-04	161	73	4	15ba7e69699558353cfeecdcf1dbc2e147379ed6
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANGPT2 TIE1 SCN5A DUOX2	1.56e-04	165	73	4	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANGPT2 TIE1 SCN5A DUOX2	1.56e-04	165	73	4	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANGPT2 TIE1 SCN5A DUOX2	1.56e-04	165	73	4	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	severe-HSPC\|severe / disease stage, cell group and cell class	VLDLR CPXM1 CPA3 PHTF1	1.56e-04	165	73	4	acd837d88ad3786c263f74651a6c0e02fa2fa2c5
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANGPT2 TIE1 SCN5A DUOX2	1.56e-04	165	73	4	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ANGPT2 TIE1 SCN5A ARHGAP29	1.60e-04	166	73	4	5ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ANGPT2 TIE1 SCN5A ARHGAP29	1.60e-04	166	73	4	6bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCell	droplet-Fat-Mat-18m-Lymphocytic-lymphocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD2L2 GVINP1 IPCEF1 HVCN1	1.83e-04	172	73	4	226de1a5d4a360d3ae01b0235fea19521ec623a0
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 TIE1 IPCEF1 ARHGAP29	1.87e-04	173	73	4	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	368C-Endothelial_cells-Endothelial-D\|368C / Donor, Lineage, Cell class and subclass (all cells)	PLK2 ANGPT2 TIE1 ARHGAP29	1.95e-04	175	73	4	c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell	368C-Endothelial_cells-Endothelial-D-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PLK2 ANGPT2 TIE1 ARHGAP29	1.95e-04	175	73	4	ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADPRH ANGPT2 TIE1 ARHGAP29	2.04e-04	177	73	4	d6596a0b6fd146fefc27717c1a7dbaa3774cc644
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.04e-04	177	73	4	b1775e05c28883a15c56628028770bc59d3233fb
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	P2RX4 MYO18A CYB561D1	2.07e-04	70	73	3	37e34ef782b253c43628d5bb2fe5e0294573d0ef
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 TIE1 CLDND2 CNGB1	2.08e-04	178	73	4	ba2f0585626988b511046630bc16be5c5fec3fb2
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 TIE1 CLDND2 CNGB1	2.08e-04	178	73	4	93ce73f8bcec63ebf86fabb546f88400e8f06465
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIE1 ARHGAP29 CPT1B TTLL7	2.13e-04	179	73	4	a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell	IIH-matDC\|IIH / Condition, Cell_class and T cell subcluster	MFAP4 COL12A1 AOC1 RGS22	2.13e-04	179	73	4	5999c85ce3bab5309ff1ed154be7e32b037750b1
ToppCell	nucseq-Epithelial-Epithelial_Glandular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AOC1 TMPRSS4 DUOX2 FER1L6	2.13e-04	179	73	4	859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IPCEF1 SCN5A ARHGAP29 TBC1D21	2.13e-04	179	73	4	53e700494d251ec5649b2dea5fc7d5aeeeed572b
ToppCell	IIH-matDC-\|IIH / Condition, Cell_class and T cell subcluster	MFAP4 COL12A1 AOC1 RGS22	2.13e-04	179	73	4	46074b2781ed79e2979428b3ec81504621d3903c
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|metastatic_Brain / Location, Cell class and cell subclass	ANGPT2 TIE1 CYB561D1 ARHGAP29	2.13e-04	179	73	4	56fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IL10RB P2RX4 MS4A7 OPHN1	2.13e-04	179	73	4	fae869fb0a91428481bf8a9c111dcc639e2b4278
ToppCell	AT1_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	DUOX1 COL12A1 GGTLC1 TTLL7	2.17e-04	180	73	4	2d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AOC1 TMPRSS4 DUOX2 FER1L6	2.17e-04	180	73	4	3dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AOC1 TMPRSS4 DUOX2 FER1L6	2.17e-04	180	73	4	668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCell	10x5'-bone_marrow-Mast-Mast_cell_lympho\|bone_marrow / Manually curated celltypes from each tissue	ANGPT2 RNF103 CPA3 TTLL7	2.22e-04	181	73	4	56fa77ae31f3b7de6e441a439c33a11353b6573a
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.27e-04	182	73	4	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TIE1 ARHGAP29 CPT1B TTLL7	2.32e-04	183	73	4	6f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.32e-04	183	73	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	P03-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ANGPT2 TIE1 SCN5A DUOX2	2.32e-04	183	73	4	89727b4f65949ed2dce9d2e0228c79fe4280230c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MFAP4 COL12A1 CPXM1 DNM1	2.32e-04	183	73	4	06a68fa2be36448064f4668be24a5b85ad85c6e8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IPCEF1 WNT7B ARHGAP29 TMPRSS4	2.32e-04	183	73	4	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	P03-Endothelial-lymphatic_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ANGPT2 TIE1 SCN5A DUOX2	2.32e-04	183	73	4	113e6d8d4bb271be984af06cd6c22b180425dcfc
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 RGS22 TENM1 ROS1	2.36e-04	184	73	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.36e-04	184	73	4	15cbddea9efb2346a2028d77edfe9ba32923568f
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.36e-04	184	73	4	0087c605c161fd8a39aa394f51994a04e8353bf1
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 RGS22 TENM1 ROS1	2.36e-04	184	73	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 RGS22 TENM1 ROS1	2.36e-04	184	73	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.36e-04	184	73	4	968afa6b5ba84169377a24c150bb68749fa674d9
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.36e-04	184	73	4	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.36e-04	184	73	4	920f95625978132c2b6c76654ef6298244103e2d
ToppCell	facs-Heart-LV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHBDL2 BEST2 WNT7B TMPRSS4	2.41e-04	185	73	4	a835f821a5e6568d648df831ec4c2d0048d67093
ToppCell	facs-Heart-LV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHBDL2 BEST2 WNT7B TMPRSS4	2.41e-04	185	73	4	386b08bcb304db543e3c5ff75f85e99bf0c592df
ToppCell	Mesenchymal_cells-Osteo-CAR\|World / Lineage and Cell class	VLDLR COL12A1 CPXM1 HVCN1	2.41e-04	185	73	4	16f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MFAP4 COL12A1 CPXM1 HVCN1	2.46e-04	186	73	4	4e983de6d2515082f9e555f4f949cec84281c140
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.46e-04	186	73	4	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.46e-04	186	73	4	9579180db2a0bf3f043b4d169f9a08cdc45b459a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RB PLK2 TIE1 IQGAP1	2.46e-04	186	73	4	a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANGPT2 TIE1 IPCEF1 ARHGAP29	2.46e-04	186	73	4	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	10x5'-Lung-Mast\|Lung / Manually curated celltypes from each tissue	TIE1 ARHGAP29 CPA3 TTLL7	2.51e-04	187	73	4	f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCell	10x5'-Lung-Mast-Mast_cells\|Lung / Manually curated celltypes from each tissue	TIE1 ARHGAP29 CPA3 TTLL7	2.51e-04	187	73	4	da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCell	367C-Endothelial_cells-Endothelial-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	PLK2 ANGPT2 TIE1 ARHGAP29	2.51e-04	187	73	4	1342bc614bc4045263c2eb0a535a1dd6c64e7abe
ToppCell	367C-Endothelial_cells-Endothelial-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	PLK2 ANGPT2 TIE1 ARHGAP29	2.51e-04	187	73	4	7aa206262b14b9f2aaa99e59da38b96c3594d2c9
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLTCL1 TIE1 IPCEF1 ARHGAP29	2.57e-04	188	73	4	524d1d928c9386acf20e53d31894107dd7290dc7
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLTCL1 TIE1 IPCEF1 ARHGAP29	2.57e-04	188	73	4	1b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLTCL1 TIE1 IPCEF1 ARHGAP29	2.57e-04	188	73	4	cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLTCL1 TIE1 IPCEF1 ARHGAP29	2.57e-04	188	73	4	f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RB PLK2 TIE1 IQGAP1	2.57e-04	188	73	4	4dc89c7843ebd078e3414e835c56f11fa27f0c5f
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RB PLK2 TIE1 IQGAP1	2.57e-04	188	73	4	d577b3c2a844e3062c7ca9e9ebc1722d0ac95caa
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RB PLK2 TIE1 IQGAP1	2.57e-04	188	73	4	1e788b60dd643bf220d8dfafa82d85fd083cbc71
ToppCell	5'-Airway_Nasal-Endothelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLTCL1 TIE1 IPCEF1 ARHGAP29	2.57e-04	188	73	4	6c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MFAP4 COL12A1 ANGPT2 TTLL7	2.62e-04	189	73	4	032f169e8ede653117919bf97c17f92043320b3c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MFAP4 COL12A1 ANGPT2 TTLL7	2.62e-04	189	73	4	07208d32afca6f93207a2ac35b647b31a9f71b7c
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WNT7B TMPRSS4 DUOX2 FER1L6	2.67e-04	190	73	4	6ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCell	facs-Large_Intestine-Distal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 RHBDL2 P2RX4 BEST2	2.67e-04	190	73	4	3964a8390522b61b73235151bb0a2ff36b856867
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l27\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLK2 RHBDL2 TIE1 MYO18A	2.67e-04	190	73	4	632d5dc11765053366d61f0a0c7916111cea4f50
Disease	tobacco smoke exposure measurement	WWP2 MYO18A CYB561D1	2.61e-05	24	71	3	EFO_0009115
Disease	phenylketonuria (implicated_via_orthology)	DUOX1 DUOX2	3.41e-05	4	71	2	DOID:9281 (implicated_via_orthology)
Disease	Brugada ECG Pattern	SCN5A SCN10A	3.41e-05	4	71	2	C1721096
Disease	cardiovascular age measurement	PKD2L2 SCN5A SCN10A	4.66e-05	29	71	3	EFO_0803380
Disease	electrocardiography, PR interval	SCN5A SCN10A	1.19e-04	7	71	2	EFO_0004327, EFO_0004462
Disease	Congenital Pain Insensitivity	CLTCL1 SCN10A	1.19e-04	7	71	2	C0002768
Disease	hereditary lymphedema (is_implicated_in)	ANGPT2 TIE1	1.19e-04	7	71	2	DOID:0050580 (is_implicated_in)
Disease	Lymphoid leukemia	CLPTM1L IPCEF1	1.58e-04	8	71	2	C0023448
Disease	supraventricular ectopy	SCN5A SCN10A	2.03e-04	9	71	2	EFO_0009277
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX1 DUOX2	2.03e-04	9	71	2	DOID:0050338 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN5A SCN10A	2.54e-04	10	71	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN5A SCN10A	2.54e-04	10	71	2	DOID:0080422 (implicated_via_orthology)
Disease	TPE interval measurement	AOC1 SCN5A SCN10A	2.71e-04	52	71	3	EFO_0004644
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN5A SCN10A	3.71e-04	12	71	2	DOID:0060170 (implicated_via_orthology)
Disease	focal segmental glomerulosclerosis (biomarker_via_orthology)	VLDLR ANGPT2	3.71e-04	12	71	2	DOID:1312 (biomarker_via_orthology)
Disease	Brugada Syndrome 1	SCN5A SCN10A	4.38e-04	13	71	2	C4551804
Disease	hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	4.38e-04	13	71	2	DOID:1459 (implicated_via_orthology)
Disease	T wave morphology measurement	SCN5A SCN10A	5.10e-04	14	71	2	EFO_0008398
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	5.10e-04	14	71	2	DOID:0050328 (implicated_via_orthology)
Disease	P wave duration	SCN5A SCN10A	5.87e-04	15	71	2	EFO_0005094
Disease	Romano-Ward Syndrome	SCN5A SCN10A	6.70e-04	16	71	2	C0035828
Disease	Brugada syndrome	SCN5A SCN10A	9.51e-04	19	71	2	MONDO_0015263
Disease	Brugada Syndrome (disorder)	SCN5A SCN10A	1.52e-03	24	71	2	C1142166
Disease	QT interval	AOC1 SCN5A SCN10A TMPRSS4 ROS1 KDM1B	1.81e-03	534	71	6	EFO_0004682
Disease	atrial fibrillation	RHBDL2 PKD2L2 SCN5A SCN10A KDM1B	2.02e-03	371	71	5	EFO_0000275

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSYNKYWVPCVWFSN	BEST2	176	Q8NFU1
YSVWFQAQIKGAAWY	CYB561D1	186	Q8N8Q1
YTEKGYNTHWNNWFI	ADAM18	676	Q9Y3Q7
IYWWKAISEGYCTEQ	GVINP1	361	Q7Z2Y8
TNKFNGIKWYYWKGS	ANGPT2	466	O15123
WRYDWVTSYKVQFSN	CPXM1	196	Q96SM3
WAVEQVWYNGKFYGS	AOC1	231	P19801
FVFDVGQKTWKSYDW	CTBS	61	Q01459
NNSKWVKHWVKGGYY	IQGAP1	681	P46940
AYVIGWVFVWEKGYQ	P2RX4	41	Q99571
EKWALGISWVKYYCQ	OPHN1	276	O60890
TFYQQLYKTQWWGAI	ANKAR	446	Q7Z5J8
SELPQKYYWWFFQTV	DUOX1	1176	Q9NRD9
KLYYKATVTKTAWYW	nan	876	O00370
ATVTKTAWYWYQNRD	nan	881	O00370
WQLYYSKKLLDSWFT	JAGN1	161	Q8N5M9
YWFVLTAENLSWYKD	DNM1	541	Q05193
VGDDYHAWNINYKKW	HVCN1	31	Q96D96
AVLFWLNYKAAYDNW	KIAA1109	3281	Q2LD37
DGSKLPQKFYWWFFQ	DUOX2	1171	Q9NRD8
YSSVFWWKQLYSNNP	MS4A7	201	Q9GZW8
NWVEYNVTGWLNYTK	MYO18A	936	Q92614
IIYNLWFGYDVKWAV	GGTLC1	141	Q9BX51
FKWTNYIKGYQRRWF	OSBP	96	P22059
YAKTWSKYTKNIVSW	ARHGAP29	211	Q52LW3
SWWNSYNKAISYLAT	DNAJC25	166	Q9H1X3
VWYCRWIYNFNIKGK	DNAJC25	261	Q9H1X3
IIYWIGTNAKTAYEW	HECTD1	1076	Q9ULT8
WVILKGSSLYWYSNQ	IPCEF1	66	Q8WWN9
SEWLKYQGKCYWFSN	KLRF1	116	Q9NZS2
YQGKCYWFSNEMKSW	KLRF1	121	Q9NZS2
GYDKYTTWKKIWTSN	KDM1B	106	Q8NB78
YAKYNNWEKIVAWTE	CPA3	116	P15088
KTYQIGWDTFCVKWS	COL12A1	2211	Q99715
KNVYNSWTYNVQYWK	IL10RB	146	Q08334
SWTYNVQYWKNGTDE	IL10RB	151	Q08334
FGWKDQRKLWVGYQY	DGCR2	176	P98153
KYWYFKHASWNGLTV	HGSNAT	291	Q68CP4
EWNKSDQYWLKIYLF	RNF103	226	O00237
KYLVLKSWWASNYVS	CPT1B	221	Q92523
IDWWSKYYASLKKAQ	FER1L6	1211	Q2WGJ9
WGVQTFTSGKYYWEV	TRIM49	331	P0CI25
FIYYAVWKPQKQWIT	RHBDL2	86	Q9NX52
QLWTKEWYIGYYQGR	SH3BP4	696	Q9P0V3
AWKFLTGYFSWQSSQ	TBC1D21	66	Q8IYX1
GNKLWKNSVYFWFDL	RGS22	686	Q8NE09
NGINWAQWKGFYYSL	MFAP4	231	P55083
YGFKKYFTNAWCWLD	SCN5A	1261	Q14524
FAWNKTDIYGQKVWG	TENM1	1081	Q9UKZ4
EWWYFRKYGTSFIEQ	ST7	81	Q9NRC1
NLQHWSYFQTKWENY	ADPRH	216	P54922
VKNAWKNNVFFSWSY	CLDND2	116	Q8NHS1
LNIKYKSWYSWLINS	CLPTM1L	421	Q96KA5
AAYLYKGNNWWAQSV	CLTCL1	1511	P53675
KSVQNRVKTWYEYTW	CNGB1	911	Q14028
WKGPDFWNKDAYYNL	UFSP2	446	Q9NUQ7
RADKYWEYTFKVNWS	ZCCHC2	366	Q9C0B9
EKQGYYNQAEGWKWG	WNT7B	136	P56706
YRHYTKNSKQIQWFW	WWP2	766	O00308
WYQKKIGAYDQQIWE	PHTF1	11	Q9UMS5
ALYWFNYELVKSWLN	SLC25A39	231	Q9BZJ4
VAYGFKKYFTNAWCW	SCN10A	1206	Q9Y5Y9
VIWKSNGSYFYTLDW	TIE1	156	P35590
WGAQAFTSGKYYWEV	TRIM51	331	Q9BSJ1
WGVQTFTSGKYYWEV	TRIM49C	331	P0CI26
LWEAGWKQRYYKNKF	XRN2	511	Q9H0D6
KVSAYLNWIYNVWKA	TMPRSS4	421	Q9NRS4
IQWKYAQLLGSWTYT	ROS1	131	P08922
RFWVELQKWKYNEFY	ROS1	1686	P08922
WTHQSKIKYDWYQTE	SUGT1	166	Q9Y2Z0
EFKSAYFKSIWNWLE	PKD2L2	306	Q9NZM6
WLWNKQKYEAGTYPQ	TRIM21	381	P19474
KYTYGVNAWKHWVKT	ZMYM2	1071	Q9UBW7
WGAQTFTSGKYYWEV	TRIM49D1	331	C9J1S8
FQWVTKWVDYSNKYG	PLK2	501	Q9NYY3
WGAQTFTSGKYYWEV	TRIM49B	331	A6NDI0
PKSENYTYIWWLNGQ	PSG5	171	Q15238
IDNWKYHKTKVASYW	TTLL7	711	Q6ZT98
DWVYKTIYWTDAASK	VLDLR	521	P98155
WKNDRQQKGESYWYS	VPS13D	121	Q5THJ4