Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGT2P GGT1 GGT3P

6.79e-0661413GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGT2P GGT1 GGT3P

6.79e-0661413GO:0002951
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGT2P GGT1 GGT3P

1.88e-0581413GO:0103068
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGT2P GGT1 GGT3P

2.81e-0591413GO:0036374
GeneOntologyMolecularFunctionomega peptidase activity

GGT2P GGT1 GGT3P

1.80e-04161413GO:0008242
GeneOntologyMolecularFunctionthreonine-type peptidase activity

GGT2P GGT1 GGT3P

3.60e-04201413GO:0070003
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

CHL1 FAT4 DSCAM PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 DSCAML1 TENM3 PVR CDH5 PCDH18

5.29e-1018714113GO:0007156
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

CHL1 FAT4 DSCAM PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 DSCAML1 PTPRD TENM3 PVR CDH5 PCDH18

3.29e-0831314114GO:0098742
GeneOntologyBiologicalProcessglutathione catabolic process

DPEP1 GGT2P GGT1 GGT3P

6.65e-07111414GO:0006751
GeneOntologyBiologicalProcessleukotriene D4 metabolic process

DPEP1 GGT2P GGT1 GGT3P

9.93e-07121414GO:1901748
GeneOntologyBiologicalProcesscell morphogenesis

CHL1 ABI1 NRDC DSCAM FGD2 CDHR1 SRF SPART LHX3 CUL7 DSCAML1 AR RYK KIAA0319 FAM171A1 SHROOM1 DLC1 PTPRD NFIX ANAPC2 CD44 DOCK7 CDH5

6.17e-06119414123GO:0000902
GeneOntologyBiologicalProcesssulfur amino acid metabolic process

DPEP1 GGT2P GGT1 GGT3P MMUT

7.55e-06401415GO:0000096
GeneOntologyBiologicalProcesscysteine biosynthetic process

GGT2P GGT1 GGT3P

1.71e-0581413GO:0019344
GeneOntologyBiologicalProcesspeptide modification

GGT2P GGT1 GGT3P

3.62e-05101413GO:0031179
GeneOntologyBiologicalProcessleukotriene D4 biosynthetic process

GGT2P GGT1 GGT3P

3.62e-05101413GO:1901750
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

CHL1 ABI1 NRDC DSCAM CDHR1 SRF SPART LHX3 CUL7 DSCAML1 RYK KIAA0319 PTPRD NFIX ANAPC2 DOCK7

5.40e-0574814116GO:0048667
GeneOntologyBiologicalProcessmodified amino acid catabolic process

DPEP1 GGT2P GGT1 GGT3P

1.16e-04371414GO:0042219
GeneOntologyBiologicalProcessexit from mitosis

KNTC1 CDC14B NFIX CTDP1

1.16e-04371414GO:0010458
GeneOntologyBiologicalProcesscell-cell adhesion

CHL1 IL12RB1 FAT4 DSCAM PCDHGA7 CDHR1 ADAM9 SRF PCDHB2 PCDHA4 PCDHA1 PTAFR DSCAML1 PTPRD TENM3 PVR CD44 CDH5 PCDH18

1.38e-04107714119GO:0098609
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

CHL1 ABI1 NRDC DSCAM SRF SPART LHX3 CUL7 DSCAML1 RYK KIAA0319 PTPRD NFIX ANAPC2 CD44 DOCK7

1.55e-0481914116GO:0120039
GeneOntologyBiologicalProcesscysteine metabolic process

GGT2P GGT1 GGT3P

1.64e-04161413GO:0006534
GeneOntologyBiologicalProcesscell projection morphogenesis

CHL1 ABI1 NRDC DSCAM SRF SPART LHX3 CUL7 DSCAML1 RYK KIAA0319 PTPRD NFIX ANAPC2 CD44 DOCK7

1.70e-0482614116GO:0048858
GeneOntologyBiologicalProcessleukotriene metabolic process

DPEP1 GGT2P GGT1 GGT3P

1.74e-04411414GO:0006691
GeneOntologyBiologicalProcessregulation of extent of cell growth

DSCAM SRF SPART RYK KIAA0319 ANAPC2

1.94e-041221416GO:0061387
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

DPEP1 ACACA GGT2P GGT1 GGT3P

2.49e-04821415GO:1901568
GeneOntologyBiologicalProcesspositive regulation of molecular function

TRADD ABI1 FGD2 ADAM9 LARS1 SRF CAT CNPY2 CDC14B AR RYK TFDP1 CEMIP RTKN2 STAC2 TTBK1 DLC1 DOCK7 AIM2 ENO1 MMUT CCS

2.81e-04143014122GO:0044093
GeneOntologyBiologicalProcessglutathione biosynthetic process

GGT2P GGT1 GGT3P

3.27e-04201413GO:0006750
GeneOntologyBiologicalProcessregulation of axonogenesis

NRDC DSCAM SRF SPART RYK KIAA0319 ANAPC2

3.59e-041921417GO:0050770
GeneOntologyBiologicalProcesssulfur amino acid biosynthetic process

GGT2P GGT1 GGT3P

3.80e-04211413GO:0000097
GeneOntologyBiologicalProcessneuron development

CHL1 FAT4 ABI1 NRDC DSCAM CDHR1 SRF ARFGEF1 SPART LHX3 CUL7 DSCAML1 RYK KIAA0319 PTPRD TENM3 NFIX ANAPC2 CD44 DOCK7 RP1 VPS13B

3.85e-04146314122GO:0048666
GeneOntologyBiologicalProcessneuron projection morphogenesis

CHL1 ABI1 NRDC DSCAM SRF SPART LHX3 CUL7 DSCAML1 RYK KIAA0319 PTPRD NFIX ANAPC2 DOCK7

3.98e-0480214115GO:0048812
GeneOntologyBiologicalProcessnonribosomal peptide biosynthetic process

GGT2P GGT1 GGT3P

4.38e-04221413GO:0019184
GeneOntologyBiologicalProcessleukotriene biosynthetic process

GGT2P GGT1 GGT3P

4.38e-04221413GO:0019370
GeneOntologyBiologicalProcessfatty acid derivative biosynthetic process

ACACA GGT2P GGT1 GGT3P

4.39e-04521414GO:1901570
GeneOntologyBiologicalProcessneuron projection development

CHL1 FAT4 ABI1 NRDC DSCAM SRF ARFGEF1 SPART LHX3 CUL7 DSCAML1 RYK KIAA0319 PTPRD TENM3 NFIX ANAPC2 CD44 DOCK7 VPS13B

4.71e-04128514120GO:0031175
GeneOntologyBiologicalProcesssulfur compound catabolic process

DPEP1 GGT2P GGT1 GGT3P

4.73e-04531414GO:0044273
GeneOntologyBiologicalProcessanatomical structure homeostasis

ACACA CDHR1 SRF SLC28A3 NFIX KMT2A RP1 CDH5 VPS13B

4.95e-043341419GO:0060249
GeneOntologyBiologicalProcesstissue homeostasis

ACACA CDHR1 SRF SLC28A3 NFIX KMT2A RP1 CDH5 VPS13B

4.95e-043341419GO:0001894
GeneOntologyBiologicalProcessaxonogenesis

CHL1 NRDC DSCAM SRF SPART LHX3 DSCAML1 RYK KIAA0319 NFIX ANAPC2 DOCK7

5.21e-0456614112GO:0007409
HumanPhenoIrregular dentition

FAT4 NFIX RIN2

1.74e-056503HP:0040079
MousePhenoabnormal circulating glutathione level

GGT2P GGT1 GGT3P

5.08e-0651133MP:0030652
MousePhenoincreased circulating glutathione level

GGT2P GGT1 GGT3P

5.08e-0651133MP:0030653
MousePhenoglutathionuria

GGT2P GGT1 GGT3P

5.08e-0651133MP:0013730
MousePhenoincreased glutathione level

GGT2P GGT1 GGT3P

5.08e-0651133MP:0012606
MousePhenodecreased circulating cysteine level

GGT2P GGT1 GGT3P

1.76e-0571133MP:0030626
MousePhenodecreased follicle stimulating hormone level

LHX3 AR GGT2P GGT1 GGT3P

2.67e-05441135MP:0005130
MousePhenodecreased cysteine level

GGT2P GGT1 GGT3P

2.80e-0581133MP:0030623
MousePhenoepididymis hypoplasia

GGT2P GGT1 GGT3P

2.80e-0581133MP:0004932
MousePhenonervous

GGT2P GGT1 GGT3P

4.17e-0591133MP:0008912
MousePhenofailure of copulatory plug deposition

GGT2P GGT1 GGT3P

5.92e-05101133MP:0030983
MousePhenoseminal vesicle hypoplasia

GGT2P GGT1 GGT3P

5.92e-05101133MP:0005148
MousePhenoovary hypoplasia

GGT2P GGT1 GGT3P

5.92e-05101133MP:0005158
MousePhenoaciduria

GGT2P GGT1 GGT3P DHTKD1 MMUT

7.96e-05551135MP:0010028
MousePhenoabnormal circulating cysteine level

GGT2P GGT1 GGT3P

8.10e-05111133MP:0030624
MousePhenoabsent tertiary ovarian follicles

GGT2P GGT1 GGT3P

8.10e-05111133MP:0011130
MousePhenodecreased circulating gonadotropin level

LHX3 AR GGT2P GGT1 GGT3P

1.21e-04601135MP:0003363
MousePhenoabnormal cysteine level

GGT2P GGT1 GGT3P

1.39e-04131133MP:0030621
MousePhenodecreased glutathione level

GGT2P GGT1 GGT3P

1.39e-04131133MP:0012604
MousePhenoabnormal glutathione level

GGT2P GGT1 GGT3P

1.39e-04131133MP:0012603
MousePhenodecreased circulating follicle stimulating hormone level

AR GGT2P GGT1 GGT3P

1.56e-04341134MP:0002790
MousePhenopriapism

GGT2P GGT1 GGT3P

1.75e-04141133MP:0003415
MousePhenothick retina inner plexiform layer

DSCAM DSCAML1

1.93e-0431132MP:0014265
MousePhenosmall epididymis

QRICH2 AR GGT2P GGT1 GGT3P

2.52e-04701135MP:0004930
MousePhenoabnormal copulatory plug deposition

GGT2P GGT1 GGT3P

2.67e-04161133MP:0030982
MousePhenodecreased spleen red pulp amount

GGT2P GGT1 GGT3P

2.67e-04161133MP:0008477
MousePhenoabnormal circulating insulin-like growth factor I level

LHX3 GGT2P GGT1 GGT3P DHTKD1

2.87e-04721135MP:0004700
MousePhenoabnormal insulin-like growth factor I level

LHX3 GGT2P GGT1 GGT3P DHTKD1

3.47e-04751135MP:0008831
MousePhenoinduced hyperactivity

PRRT2 GGT2P GGT1 GGT3P

3.58e-04421134MP:0008911
MousePhenofailure of superovulation

GGT2P GGT1 GGT3P

3.84e-04181133MP:0031422
MousePhenoabnormal penile erection

GGT2P GGT1 GGT3P

3.84e-04181133MP:0001379
MousePhenooocyte degeneration

GGT2P GGT1 GGT3P

3.84e-04181133MP:0009093
MousePhenoincreased spleen neoplasm incidence

MZF1 KMT2A

3.85e-0441132MP:0005649
MousePhenoincreased circulating growth hormone level

GGT2P GGT1 GGT3P

4.53e-04191133MP:0005123
MousePhenoabnormal copulation physiology

GGT2P GGT1 GGT3P

4.53e-04191133MP:0031627
MousePhenokyphosis

FAT4 DSCAM CDC14B GGT2P GGT1 GGT3P THBS2 NFIX

5.37e-042291138MP:0000160
MousePhenoenlarged lateral ventricles

CHL1 NRDC DSCAM ARFGEF1 NFIX

5.87e-04841135MP:0008535
MousePhenosmall vertebrae

GGT2P GGT1 GGT3P

7.08e-04221133MP:0004610
MousePhenodecreased thyroxine level

LHX3 GGT2P GGT1 GGT3P

7.55e-04511134MP:0005471
MousePhenodecreased circulating pituitary hormone level

LHX3 AR GGT2P GGT1 GGT3P

7.64e-04891135MP:0005118
MousePhenoabnormal follicle stimulating hormone level

LHX3 AR GGT2P GGT1 GGT3P

7.64e-04891135MP:0003967
MousePhenoincreased growth hormone level

GGT2P GGT1 GGT3P

8.10e-04231133MP:0005137
MousePhenouterus hypoplasia

GGT2P GGT1 GGT3P

8.10e-04231133MP:0001121
MousePhenoabnormal copulation behavior

GGT2P GGT1 GGT3P

9.20e-04241133MP:0009697
MousePhenonarrow head

KIAA0586 GTF2I

9.51e-0461132MP:0003742
DomainCadherin

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 KIAA0319 CDH5 PCDH18

2.43e-071181399IPR002126
DomainCadherin_CS

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 CDH5 PCDH18

1.55e-061091398IPR020894
DomainCADHERIN_1

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 CDH5 PCDH18

2.04e-061131398PS00232
DomainCadherin

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 CDH5 PCDH18

2.04e-061131398PF00028
DomainCADHERIN_2

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 CDH5 PCDH18

2.18e-061141398PS50268
Domain-

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 CDH5 PCDH18

2.18e-0611413982.60.40.60
DomainCA

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 CDH5 PCDH18

2.33e-061151398SM00112
DomainCadherin-like

FAT4 PCDHGA7 CDHR1 PCDHB2 PCDHA4 PCDHA1 CDH5 PCDH18

2.48e-061161398IPR015919
DomainCadherin_2

PCDHGA7 PCDHB2 PCDHA4 PCDHA1 PCDH18

1.23e-04651395PF08266
DomainCadherin_N

PCDHGA7 PCDHB2 PCDHA4 PCDHA1 PCDH18

1.23e-04651395IPR013164
DomainFYrich_C

KMT2C KMT2A

5.42e-0451392IPR003889
DomainFYrich_N

KMT2C KMT2A

5.42e-0451392IPR003888
DomainFYRC

KMT2C KMT2A

5.42e-0451392SM00542
DomainFYRN

KMT2C KMT2A

5.42e-0451392SM00541
DomainFYRN

KMT2C KMT2A

5.42e-0451392PF05964
DomainFYRC

KMT2C KMT2A

5.42e-0451392PF05965
DomainFYRC

KMT2C KMT2A

5.42e-0451392PS51543
DomainFYRN

KMT2C KMT2A

5.42e-0451392PS51542
PathwayWP_EICOSANOID_SYNTHESIS

DPEP1 GGT2P GGT1 GGT3P

2.56e-05221134MM15961
PathwayWP_OXYLIPINS_PATHWAYS

DPEP1 GGT2P GGT1 GGT3P

3.67e-05241134MM17249
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

DPEP1 GGT2P GGT1 GGT3P

4.35e-05251134MM14858
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

DPEP1 GGT2P GGT1 GGT3P

5.11e-05261134MM15190
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

DPEP1 GGT2P GGT1 GGT3P

1.34e-04331134MM15963
PathwayREACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING

GGT2P GGT1 GGT3P

2.60e-04161133MM14680
Pubmed

Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase.

DPEP1 GGT2P GGT1 GGT3P

3.86e-09614148663190
Pubmed

Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.

GGT2P GGT1 GGT3P

6.52e-08314132573352
Pubmed

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.

GGT2P GGT1 GGT3P

6.48e-075141323615310
Pubmed

gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.

GGT2P GGT1 GGT3P

6.48e-075141311003618
Pubmed

Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

GGT2P GGT1 GGT3P

6.48e-075141310392451
Pubmed

Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.

GGT2P GGT1 GGT3P

6.48e-075141319850887
Pubmed

Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

6.48e-075141312810527
Pubmed

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

6.48e-07514138755578
Pubmed

Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

6.48e-075141311089562
Pubmed

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

GGT2P GGT1 GGT3P

6.48e-075141326977590
Pubmed

Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.

GGT2P GGT1 GGT3P

6.48e-075141312225953
Pubmed

Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.

GGT2P GGT1 GGT3P

6.48e-07514137775425
Pubmed

Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.

GGT2P GGT1 GGT3P

6.48e-07514139139708
Pubmed

Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.

GGT2P GGT1 GGT3P

6.48e-075141320622017
Pubmed

Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

6.48e-07514139546365
Pubmed

gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?

GGT2P GGT1 GGT3P

6.48e-07514137485380
Pubmed

Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase.

GGT2P GGT1 GGT3P

6.48e-075141310751614
Pubmed

Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the mouse small intestine.

GGT2P GGT1 GGT3P

6.48e-07514137523374
Pubmed

Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase.

GGT2P GGT1 GGT3P

6.48e-075141324698228
Pubmed

gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.

GGT2P GGT1 GGT3P

6.48e-075141310474818
Pubmed

Lung lining fluid glutathione attenuates IL-13-induced asthma.

GGT2P GGT1 GGT3P

6.48e-075141318063838
Pubmed

Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

GGT2P GGT1 GGT3P

6.48e-075141310940879
Pubmed

Cataract development in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

6.48e-075141311095909
Pubmed

Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells.

GGT2P GGT1 GGT3P

6.48e-07514137641802
Pubmed

The mouse skin carcinogenesis model.

GGT2P GGT1 GGT3P

6.48e-07514139627710
Pubmed

Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.

GGT2P GGT1 GGT3P

6.48e-075141312453183
Pubmed

Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney.

GGT2P GGT1 GGT3P

6.48e-07514132891746
Pubmed

Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.

GGT2P GGT1 GGT3P

6.48e-075141328660214
Pubmed

Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

6.48e-075141312468440
Pubmed

Cloning of cDNA and genomic structure of the mouse gamma-glutamyl transpeptidase-encoding gene.

GGT2P GGT1 GGT3P

6.48e-07514138566783
Pubmed

Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.

GGT2P GGT1 GGT3P

6.48e-075141330591459
Pubmed

In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.

GGT2P GGT1 GGT3P

6.48e-075141311795900
Pubmed

Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma.

GGT2P GGT1 GGT3P

6.48e-075141325132819
Pubmed

Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.

GGT2P GGT1 GGT3P

6.48e-075141319760322
Pubmed

Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.

GGT2P GGT1 GGT3P

1.29e-066141314634009
Pubmed

Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.

GGT2P GGT1 GGT3P

1.29e-06614138101000
Pubmed

Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes.

GGT2P GGT1 GGT3P

1.29e-06614138104871
Pubmed

Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.

GGT2P GGT1 GGT3P

1.29e-066141311463821
Pubmed

Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.

GGT2P GGT1 GGT3P

1.29e-066141325326709
Pubmed

Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.

GGT2P GGT1 GGT3P

1.29e-066141312163373
Pubmed

Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.

GGT2P GGT1 GGT3P

1.29e-066141322242126
Pubmed

Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.

GGT2P GGT1 GGT3P

1.29e-066141317363454
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ACACA STXBP4 LARS1 SPART KIF4A SRCAP NPLOC4 HNRNPH1 CCNT1 GTF2A1 GTF2I PDLIM3 PRRC2C KMT2A ENO1 AHNAK2

1.36e-069341411633916271
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

MED16 LIN54 KIF4A MIDEAS AR PCF11 CCNT1 NFIX KMT2A

1.62e-06268141933640491
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

AMFR HYOU1 ACACA SPART TARS2 HNRNPH1 GTF2I PRRC2C DOCK7 ENO1 MMUT STOML2

2.01e-065341411235032548
Pubmed

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

GGT2P GGT1 GGT3P

2.26e-067141332284594
Pubmed

m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis.

GGT2P GGT1 GGT3P

2.26e-067141336685533
Pubmed

γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.

GGT2P GGT1 GGT3P

2.26e-067141327775020
Pubmed

Defective epidermal growth factor gene expression in mice with polycystic kidney disease.

GGT2P GGT1 GGT3P

2.26e-06714131968405
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ACACA KIF4A POGZ SRCAP MIDEAS TAB3 KMT2C GTF2I PRRC2C DOCK7 KMT2A ENO1

2.68e-065491411238280479
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KNTC1 KIAA0586 CUL7 TUBGCP5 USP20 ANO8 PCF11 TSC22D1 TTBK1 DHTKD1 PCDH18

5.84e-064931411115368895
Pubmed

Renalase regulates renal dopamine and phosphate metabolism.

GGT2P GGT1 GGT3P

7.67e-0610141323863468
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ABI1 DSCAM ADAM9 HECTD4 WDR81 KIF4A ARHGEF11 KIAA0319 FAM171A1 PTPRD PRRC2C NISCH DOCK7 ENO1 STOML2

9.25e-069631411528671696
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ENGASE ACACA INTS1 HECTD4 SRCAP ARHGEF11 CDC14B ANO8 KMT2C KANSL1 NEK8 NISCH CTDP1 AP1G2 SUFU AHNAK2

1.13e-0511051411635748872
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHGA7 PCDHB2 PCDHA4 PCDHA1 PCDH18

1.31e-0574141510817752
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

HYOU1 ACACA INTS1 KIF4A POGZ CUL7 GTF2I PRRC2C DOCK7 KMT2A MVP STOML2

1.53e-056531411222586326
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHGA7 PCDHB2 PCDHA4 PCDHA1 PCDH18

1.59e-0577141510835267
Pubmed

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.

CD44 CDH5

1.63e-052141231996681
Pubmed

Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.

GGT2P GGT1

1.63e-052141225180444
Pubmed

Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.

SRF AR

1.63e-052141215623502
Pubmed

The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation.

SRF PDLIM3

1.63e-052141217332502
Pubmed

ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23).

ABI1 KMT2A

1.63e-05214129694699
Pubmed

Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.

DSCAM DSCAML1

1.63e-052141221645617
Pubmed

Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

GGT2P GGT1

1.63e-052141225280803
Pubmed

Intragenic integration in DLC1 sustains factor VIII expression in primary human cells without insertional oncogenicity.

F8 DLC1

1.63e-052141224553346
Pubmed

Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion?

PVR CD44

1.63e-052141222363471
Pubmed

Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?

ABI1 KMT2A

1.63e-052141212547160
Pubmed

Generation of the tumor-suppressive secretome from tumor cells.

CD44 ENO1

1.63e-052141234373756
Pubmed

DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex.

DSCAM DSCAML1

1.63e-052141225451118
Pubmed

Clinical application value of hepatitis B virus basal core promoter 1762/1764 and GGTII and GGT in patients with HBV-DNA-positive primary liver cancer.

GGT2P GGT1

1.63e-052141237904480
Pubmed

Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?

DSCAM DSCAML1

1.63e-052141212051741
Pubmed

Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling.

GGT2P GGT1

1.63e-052141223682772
Pubmed

Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.

KIF4A MVP

1.63e-052141229204984
Pubmed

Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells.

ADAM9 AR

1.63e-052141217342749
Pubmed

Targeting the KIF4A/AR Axis to Reverse Endocrine Therapy Resistance in Castration-resistant Prostate Cancer.

KIF4A AR

1.63e-052141231796514
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHGA7 PCDHB2 PCDHA4 PCDHA1 PCDH18

1.92e-0580141510716726
Pubmed

Human transcription factor protein interaction networks.

LIN54 LARS1 LHX3 POGZ CUL7 SRCAP MIDEAS TFDP1 TAB3 PCF11 KMT2C GTF2I KANSL1 PRRC2C NFIX ZKSCAN3 KMT2A SUFU

2.03e-0514291411835140242
Pubmed

The human gamma-glutamyltransferase gene family.

GGT2P GGT1 GGT3P

2.30e-0514141318357469
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

HYOU1 ACACA LARS1 WDR81 SRCAP HNRNPH1 RTKN2 PDLIM3 KMT2A ENO1 CCDC9 STOML2 AHNAK2

2.66e-058071411330575818
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

KMT2C GTF2I KANSL1 KMT2A

2.83e-0543141433472061
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

LARS1 CAT DENND4C GTF2I PRRC2C CD44 ENO1 AHNAK2

3.13e-05298141830737378
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ADAM9 POGZ KIAA0319 KANSL1 TENM3 PRRC2C NISCH DOCK7 VPS13B

4.53e-05407141912693553
Pubmed

Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor.

AR CD44

4.88e-053141220200161
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2C KMT2A

4.88e-053141223932714
Pubmed

CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression.

CD44 CDH5

4.88e-053141224425872
Pubmed

The chromatin remodeling factor SRCAP modulates expression of prostate specific antigen and cellular proliferation in prostate cancer cells.

SRCAP AR

4.88e-053141220432434
Pubmed

Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations.

DSCAM DSCAML1

4.88e-053141227637097
Pubmed

Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase.

PTAFR CDH5

4.88e-053141215791001
Pubmed

cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.

SRF GTF2I

4.88e-053141212082086
Pubmed

An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase.

GTF2A1 KMT2A

4.88e-053141220506501
Pubmed

Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor.

AR NISCH

4.88e-053141215028622
Pubmed

Androgen induction of the androgen receptor coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancer.

SRF AR

4.88e-053141217975004
Pubmed

Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.

FAT4 TSC22D1

4.88e-053141221764761
Pubmed

A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I.

SRF GTF2I

4.88e-05314129334314
Pubmed

Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome.

GGT2P GGT1 GGT3P

5.09e-0518141317097888
Pubmed

Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.

KIF4A TSC22D1 GTF2I ENO1 MVP STOML2

7.09e-05170141636470425
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

HYOU1 NRDC ADAM9 TARS2 NPLOC4 CEMIP PRRC2C NISCH ANAPC2 DOCK7 KMT2A

7.33e-056501411138777146
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

FAT4 ACACA DSCAM LIN54 PCDHB2 ARFGEF1 KIF4A PCF11 GTF2I TENM3 CD44 DOCK7

8.18e-057771411235844135
Pubmed

Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung.

TAB3 NFIX DOCK7

8.22e-0521141315328023
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

PCDHGA7 PCDHB2 PCDHA4 PCDHA1

8.65e-0557141432633719
InteractionNFIX interactions

LIN54 SRF POGZ SRCAP MIDEAS AR TFDP1 HNRNPH1 KMT2C NFIX KMT2A ENO1

5.03e-0822713712int:NFIX
InteractionRYK interactions

FAT4 ABI1 PCDHGA7 CDHR1 PCDHB2 RYK FAM171A1 PTPRD PVR CDH5 PCDH18

2.24e-0721213711int:RYK
InteractionPCDHGB1 interactions

FAT4 PCDHGA7 PCDHB2 PCDHA1 FAM171A1 PCDH18

1.41e-05771376int:PCDHGB1
InteractionGGT1 interactions

ECSIT GGT2P GGT1 CEMIP

2.31e-05251374int:GGT1
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGT2P GGT1 GGT3P

3.18e-0513893564
GeneFamilyClustered protocadherins

PCDHGA7 PCDHB2 PCDHA4 PCDHA1

2.78e-046489420
GeneFamilyFibronectin type III domain containing

CHL1 IL12RB1 DSCAM DSCAML1 PTPRD

1.16e-03160895555
ToppCellLPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KNTC1 FGD2 MED16 PTAFR KIAA0319 EYS NEK8

6.46e-0715514174559e3011514041b65c17ae4ede29da202bce14c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CHL1 DSCAML1 THBS2 PTPRD PDLIM3 TENM3 NFIX

2.18e-0618614174d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCellCOVID-19-kidney-Fibroblast-1|kidney / Disease (COVID-19 only), tissue and cell type

THBS2 DLC1 PDLIM3 TENM3 AOC3 CD44 PCDH18

3.41e-0619914179503646ff1ad248181146ce767e9d12e882ec3bd
ToppCellHippocampus-Endothelial-MURAL|Hippocampus / BrainAtlas - Mouse McCarroll V32

PARP3 GGT1 PDLIM3 AOC3 SLC38A11 AIM2

1.13e-0515814162d73b5e59c650c603fec6223b1c51f0962f7bc81
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PARP3 GGT1 PDLIM3 AOC3 SLC38A11 AIM2

1.13e-0515814167f4a644534b78f7e7539cae1fd895dad6f96862b
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LIN54 WDR81 ARHGEF11 CDC14B ANO8 AIM2

1.60e-05168141693b7138f17aa14a6398c9b4ea7237781a0e19a66
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LIN54 WDR81 ARHGEF11 CDC14B ANO8 AIM2

1.60e-051681416e393553208617a023f1646169c892a87c95db3f5
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC28A3 CAT QRICH2 SHROOM1 ACSM3 PVR

1.60e-051681416100ab6d36592b61f4db9f8cb90c48afac016d679
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC28A3 CAT QRICH2 SHROOM1 ACSM3 NFIX

2.02e-0517514166bb8fc2959583644f16b22e906af91af62a3a633
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC28A3 CAT QRICH2 SHROOM1 ACSM3 NFIX

2.02e-0517514168902c38067f025b094ca9c28c449c32a66eded1c
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

HECTD4 DSCAML1 ACSM3 DLC1 TENM3 SLC38A11

2.76e-0518514161d874608aa2062024323512f68889219471b2f00
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADAM9 WDR81 PTAFR GGT1 RIN2 CCDC9

3.11e-051891416a2f4f1dd5452f7efb7427919a0b90875cf2e1dc7
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAM9 WDR81 PTAFR GGT1 RIN2 CCDC9

3.11e-05189141654a45b0cb7dea01caf1cf0a2664c40e5779a0b61
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HECTD4 CAT MOSPD1 TAB3 NFIX CCS

3.49e-051931416305e15ee467826ee08b2617c69f250ad39c11b19
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HECTD4 CAT MOSPD1 TAB3 NFIX CCS

3.49e-051931416dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCDHGA7 PRRT2 THBS2 PTPRD TENM3 PCDH18

3.81e-05196141657df2a57b35be9851ac0b1e5731baa53052511f0
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CHL1 PRRT2 TSC22D1 THBS2 DLC1 PCDH18

4.03e-051981416a8c21f4db6730d0aa05b61fbe72bf9f7571a9015
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CHL1 PRRT2 TSC22D1 THBS2 DLC1 PCDH18

4.03e-0519814168b68fc887e5ad0a59ea4d93dfd1edda67030f142
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CHL1 PRRT2 TSC22D1 THBS2 DLC1 PCDH18

4.03e-0519814164739b2e4ab141c66772e61686b45614a1839483e
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

TSC22D1 GTF2I PTPRD PRRC2C NFIX KMT2A

4.03e-051981416de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ARFGEF1 HNRNPH1 CCNT1 KANSL1 PRRC2C VPS13B

4.14e-051991416f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellInfluenza-Influenza_Severe-Others-RBC|Influenza_Severe / Disease, condition lineage and cell class

HECTD4 CAT MOSPD1 USP20 TAB3 NFIX

4.14e-051991416da0fec0a492bc3827d9066d2590bcd466cd45564
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CHL1 FAT4 F8 FAM171A1 SHROOM1 CDH5

4.26e-052001416ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FAT4 FAM171A1 KMT2C DLC1 KMT2A CDH5

4.26e-052001416dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

OAS2 SLFN5 KMT2C KANSL1 PRRC2C KMT2A

4.26e-05200141612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellmild-CD163+_Monocytes_(Sample_ID1_d7)|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FGD2 OAS2 PTAFR OTOF RIN2 AIM2

4.26e-05200141699eb02f974ddc8d1882f4a5b34d4503d6ec0a5f5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate|GW23 / Sample Type, Dataset, Time_group, and Cell type.

CDHR1 KIAA0586 WDR81 F8 DSCAML1 TENM3

4.26e-052001416fe772d98c461c973dfc082e1fc50117c27ced804
ToppCellBiopsy_IPF-Mesenchymal-Myofibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

FAT4 THBS2 PTPRD PDLIM3 AOC3 PCDH18

4.26e-052001416c2c6f687c49ba790174b27c7b8b084af30b34c86
Drug0317956-0000 [391210-11-0]; Up 200; 10uM; MCF7; HT_HG-U133A

MED16 SRF CUL7 SRCAP SIRT4 GTF2I TENM3 PVR KMT2A

3.49e-0619414193855_UP
DrugFlecainide acetate [54143-56-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

PARP3 CUL7 SRCAP ARHGEF11 CDC14B SIRT4 CCNT1 PVR KMT2A

3.64e-0619514193843_UP
DrugOzagrel hydrochloride [78712-43-3]; Down 200; 15.2uM; MCF7; HT_HG-U133A

ENGASE ARHGEF11 USP20 GTF2I MZF1 RIN2 CTDP1 CD44 KMT2A

3.64e-0619514193503_DN
Drugp-nitrophenylhydrazine

ACACA CAT AOC3

1.90e-0591413CID000069472
Drug2-ethylhydracrylic acid

AR PTPRD MMUT

2.70e-05101413CID000188979
DrugCP-645525-01 [287190-82-3]; Up 200; 10uM; MCF7; HT_HG-U133A

AMFR KIAA0586 ARFGEF1 ARHGEF11 GTF2I CTDP1 CD44 MVP

2.90e-0519414187522_UP
Drugpioglitazone HCl; Up 200; 10uM; MCF7; HT_HG-U133A

AMFR SRF ARHGEF11 DLC1 CTDP1 CD44 AIM2 MVP

2.90e-0519414187523_UP
DrugHexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A

AMFR TRADD MAN2C1 DSCAM MED16 ARHGEF11 RYK HNRNPH1

2.90e-0519414183447_DN
DrugEtidronic acid, disodium salt [7414-83-7]; Down 200; 16uM; MCF7; HT_HG-U133A

MED16 SRCAP USP20 GTF2A1 DLC1 PVR CD44 AHNAK2

2.90e-0519414184387_DN
Drug2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A

AMFR MED16 INTS1 ECSIT TUBGCP5 MZF1 CD44 CCDC9

3.00e-0519514181639_DN
DrugFusaric acid [536-69-6]; Up 200; 22.4uM; PC3; HT_HG-U133A

TRADD MAN2C1 MED16 IFFO1 SRF SIRT4 ACSM3 PTPRD

3.12e-0519614183986_UP
Drug(+,-)-Synephrine [94-07-5]; Down 200; 24uM; MCF7; HT_HG-U133A

MAN2C1 DSCAM SPART CUL7 SRCAP HNRNPH1 GTF2A1 RIN2

3.12e-0519614186798_DN
DrugEstropipate [7280-37-7]; Down 200; 9.2uM; HL60; HT_HG-U133A

TRADD ARFGEF1 ECSIT ARHGEF11 F8 RYK DENND4C CTDP1

3.12e-0519614182506_DN
DrugCGX 0596987; Down 200; 20uM; MCF7; HT_HG-U133A

AMFR SPART PTAFR ARHGEF11 DLC1 PDLIM3 AOC3 CCDC9

3.23e-0519714186412_DN
Drug(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; MCF7; HT_HG-U133A

IL12RB1 DSCAM SRF SRCAP SIRT4 PVR ZKSCAN3 AP1G2

3.23e-0519714183870_DN
DrugOfloxacin [82419-36-1]; Down 200; 11uM; PC3; HT_HG-U133A

AMFR MED16 SRCAP ARHGEF11 HNRNPH1 MZF1 CTDP1 CCS

3.35e-0519814187372_DN
DrugCorynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A

ENGASE MED16 SRCAP CDC14B MZF1 PVR ZKSCAN3 AHNAK2

3.35e-0519814182786_DN
DrugEtofylline [519-37-9]; Down 200; 17.8uM; MCF7; HT_HG-U133A

IL12RB1 DSCAM SRCAP AR CEMIP CCNT1 TENM3 MZF1

3.35e-0519814182256_DN
DrugCP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A

TRADD DSCAM POGZ SRCAP GTF2A1 AP1G2 AIM2 CCDC9

3.35e-0519814187549_UP
DrugNalidixic acid sodium salt hydrate; Up 200; 14.6uM; PC3; HT_HG-U133A

IL12RB1 CUL7 SRCAP LCT RYK HNRNPH1 USP20 AIM2

3.47e-0519914187367_UP
DrugKhellin [82-02-0]; Up 200; 15.4uM; HL60; HG-U133A

TRADD MED16 KIAA0586 RYK GTF2I MZF1 PVR ANAPC2

3.47e-0519914182004_UP
Drug2-propylpentanoic acid; Down 200; 1000uM; HL60; HG-U133A

AMFR OAS2 ECSIT ARHGEF11 HNRNPH1 DENND4C GTF2I ZKSCAN3

3.60e-052001418409_DN
DrugAC1NAQHG

MAN2C1 CCS

3.81e-0521412CID004481062
DrugMaoba

LCT ACSM3

3.81e-0521412CID000476290
Drug4-hydroxynonenal

IL12RB1 HYOU1 PARP3 CAT AR SIRT4 GGT1 CCNT1 NFIX AOC3 RP1 ENO1

3.82e-0547114112CID000001693
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGT2P GGT1 GGT3P

3.46e-0671383DOID:5022 (biomarker_via_orthology)
Diseasealcohol dependence (biomarker_via_orthology)

GGT2P GGT1 GGT3P

5.51e-0681383DOID:0050741 (biomarker_via_orthology)
DiseaseDiabetes Mellitus

ZFP57 CAT THBS2 AOC3

1.49e-05321384C0011849
DiseaseFetal Alcohol Spectrum Disorders

CHL1 SRF CAT

2.77e-05131383C2985290
DiseaseFetal Alcohol Syndrome

CHL1 SRF CAT

6.49e-05171383C0015923
DiseaseNeurodevelopmental Disorders

DSCAM POGZ SRCAP KMT2C KMT2A

7.77e-05931385C1535926
DiseaseAlcoholic Intoxication, Chronic

NRDC CAT DSCAML1 AR GGT1 ALDH3B2 CDH5

2.78e-042681387C0001973
Diseasestimulant use measurement

RYK EYS DLC1

3.01e-04281383EFO_0600076
DiseaseAcute Myeloid Leukemia, M1

KMT2C GTF2I PVR CD44 KMT2A

3.11e-041251385C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

KMT2C GTF2I PVR CD44 KMT2A

3.11e-041251385C1879321
DiseaseHereditary Diffuse Gastric Cancer

FAT4 CNPY2 KMT2C DLC1 CD44 KMT2A ENO1

4.74e-042931387C1708349
DiseaseColorectal Carcinoma

CHL1 DPEP1 ACACA ARFGEF1 DSCAML1 KMT2C DLC1 PTPRD KCNA10 ZKSCAN3 CDH5

4.79e-0470213811C0009402
DiseaseStomach Neoplasms

FAT4 CNPY2 KMT2C DLC1 CD44 KMT2A ENO1

5.14e-042971387C0038356
DiseaseMalignant neoplasm of stomach

FAT4 CNPY2 KMT2C DLC1 CD44 KMT2A ENO1

5.46e-043001387C0024623
Diseaselysosomal Pro-X carboxypeptidase measurement

PCF11 RP1

5.97e-0481382EFO_0801777
Diseasecataract (implicated_via_orthology)

INTS1 VPS13B CCS

7.49e-04381383DOID:83 (implicated_via_orthology)
Diseasecreatinine measurement

DPEP1 DSCAM LHX3 AR NPLOC4 USP20 CEMIP STAC2 ACSM3 DLC1 PRRC2C DOCK7 SUFU

8.19e-0499513813EFO_0004518
Diseaseforced expiratory volume, body mass index

HECTD4 PCDHA1

1.16e-03111382EFO_0004314, EFO_0004340
DiseaseLeukemia, Myelocytic, Acute

KMT2C GTF2I PVR CD44 KMT2A

1.35e-031731385C0023467
DiseaseMalignant neoplasm of breast

AMFR MAN2C1 STXBP4 CAT AR MOSPD1 GTF2A1 PTPRD OTOF NISCH ENO1 CDH5 VPS13B

1.63e-03107413813C0006142
DiseaseCarcinoma, Granular Cell

FAT4 KMT2C KMT2A ENO1

2.19e-031161384C0205644
DiseaseAdenocarcinoma, Tubular

FAT4 KMT2C KMT2A ENO1

2.19e-031161384C0205645
DiseaseAdenocarcinoma, Oxyphilic

FAT4 KMT2C KMT2A ENO1

2.19e-031161384C0205642
DiseaseCarcinoma, Cribriform

FAT4 KMT2C KMT2A ENO1

2.19e-031161384C0205643
DiseaseAdenocarcinoma, Basal Cell

FAT4 KMT2C KMT2A ENO1

2.19e-031161384C0205641
DiseaseAdenocarcinoma

FAT4 KMT2C KMT2A ENO1

2.19e-031161384C0001418
DiseaseDown syndrome (implicated_via_orthology)

DSCAM DSCAML1

2.19e-03151382DOID:14250 (implicated_via_orthology)
DiseaseMuscle hypotonia

INTS1 KANSL1

2.82e-03171382C0026827
Diseasehypertension (implicated_via_orthology)

SRF AR ACSM3 NISCH

3.12e-031281384DOID:10763 (implicated_via_orthology)
DiseaseMammary Carcinoma, Human

MAN2C1 STXBP4 CAT AR PTPRD NISCH ENO1 CDH5

3.37e-035251388C4704874
DiseaseMammary Neoplasms, Human

MAN2C1 STXBP4 CAT AR PTPRD NISCH ENO1 CDH5

3.37e-035251388C1257931
DiseaseMammary Neoplasms

MAN2C1 STXBP4 CAT AR PTPRD NISCH ENO1 CDH5

3.45e-035271388C1458155
Diseasetype 2 diabetes mellitus (is_marker_for)

CAT F8 GGT1 AOC3

3.88e-031361384DOID:9352 (is_marker_for)
DiseaseBreast Carcinoma

MAN2C1 STXBP4 CAT AR PTPRD NISCH ENO1 CDH5

3.90e-035381388C0678222
DiseaseBenign Neoplasm

SRF CAT DLC1

4.02e-03681383C0086692
DiseaseNeoplasms

SRF CAT DLC1

4.02e-03681383C0027651
DiseaseProfound Mental Retardation

CHL1 PRRT2 KANSL1 SC5D

4.19e-031391384C0020796
DiseaseMental Retardation, Psychosocial

CHL1 PRRT2 KANSL1 SC5D

4.19e-031391384C0025363
DiseaseMental deficiency

CHL1 PRRT2 KANSL1 SC5D

4.19e-031391384C0917816

Protein segments in the cluster

PeptideGeneStartEntry
AQPGQVVAPGAVLVR

CTDP1

96

Q9Y5B0
PSAVRGFQPIEIQQV

CDX4

266

O14627
GPRGIFRVVPQTVLN

CDHR1

401

Q96JP9
PQGVKEVFQLQRPQG

C8orf74

6

Q6P047
QQGVLREEPPGTFSV

ANAPC2

701

Q9UJX6
VGNNTPIFFIRDPIL

CAT

146

P04040
ICRPGSVIGPQQQFL

CDC14B

346

O60729
GVVFQISQPPEQELG

ARFGEF1

1831

Q9Y6D6
QTQPLGTIVNGLFVV

AIM2

256

O14862
RQVFQVLEEQPPGTL

FAT4

46

Q6V0I7
VGVRPGDAIQVQPLV

SPATA5

121

Q8NB90
SPVEVKPGNVRNIIQ

ARHGEF11

556

O15085
EGVQLNLSFIRPPEN

AP1G2

676

O75843
QLTPQIPLTGFVARV

ABI1

371

Q8IZP0
PNLFRQVQAEVPGSP

ACACA

331

Q13085
QGVQPTQPTAFEFVR

CCNT1

671

O60563
QEEIFGPILPIVNVQ

ALDH3B2

251

P48448
VPEIQALVQTLQGPF

DHTKD1

86

Q96HY7
PPAGNRAQVIINITD

CDH5

351

P33151
TLPIGQNFPIRGIQL

CEMIP

866

Q8WUJ3
IPELAARGIIQQVFP

ANO8

196

Q9HCE9
AIVFFGRQPQPNVSE

AOC3

126

Q16853
QYQVTVPENVPVGTR

PCDHGA7

246

Q9Y5G6
AQPGEVQRSLVQPGI

QRICH2

616

Q9H0J4
ELDGQQVVVPQGQPV

PARP3

486

Q9Y6F1
DNVPVVIGPALRNNT

PCDH18

571

Q9HCL0
PIIPNFVAQGAERVS

PCDHB2

771

Q9Y5E7
VTQTRQGFLPPLNVN

ANKRD34B

441

A5PLL1
LFQPSIQLARQGFPV

GGT3P

156

A6NGU5
GLPIRPEQQAVFFTL

OR1J2

16

Q8NGS2
VVQIVSGFQGARPQP

FAM171A1

131

Q5VUB5
VSIGPRDGNFLNIPQ

NFIX

481

Q14938
ERFLVPPQQIQGSGV

KMT2C

2496

Q8NEZ4
IQTQARLPFNGIIPS

LIN54

501

Q6MZP7
EPVGFQGCIRQVIIN

EYS

2861

Q5T1H1
VIAVNEVGRSQPSQP

CHL1

686

O00533
PQQLLLFVQSFGIPV

INTS1

1241

Q8N201
QELARVVQGSPEVPG

INTS1

1386

Q8N201
EVAPSGQGERVVNVP

IZUMO1R

116

A6ND01
RNVFVSPIDVGCQPV

KRT37

21

O76014
DQQAVPDVTRIGPSQ

KIAA1109

1871

Q2LD37
SFEGIQLPQVPGRVL

CUL7

236

Q14999
QEFQVPDVLRGPNTI

FAM205A

206

Q6ZU69
ISQNPFPIENRDVLG

NPLOC4

466

Q8TAT6
NGLFVTPVPVLAAQR

OR56B1

161

Q8NGI3
RQPELVEGNLPVFVF

MOSPD1

6

Q9UJG1
GAVEQPQPQFISRFL

NEK8

371

Q86SG6
ALRPVNGVINTLQPV

KANSL1

541

Q7Z3B3
AGPTISPVRQEEVQF

LCT

1856

P09848
NDVIPFVRRTVPEGQ

KNTC1

606

P50748
GIPPTQVVRRAQDFV

LHX3

96

Q9UBR4
VAQFGPQKEPVRQQI

TUBGCP5

866

Q96RT8
LTENIQRFLPNPAGV

F8

606

P00451
LFQSVREVIQNPGPR

AR

26

P10275
IVPNGITLPVDFQGR

HNRNPH1

136

P31943
SINEQEGIATVRFPP

HECTD4

1766

Q9Y4D8
QEPEQFPLVQGVAIG

OAS2

46

P29728
RPRDQAVFPQNGLVV

MVP

621

Q14764
LPVNNIFQQISPVVG

MED16

316

Q9Y2X0
INDNPPVFRGREQII

PCDHA1

126

Q9Y5I3
AFLPIIPNTQRGQLE

FAM81B

101

Q96LP2
VQTGFVSPIRPLGLQ

IFFO1

126

Q0D2I5
QQVQPRFDGVPQRFD

PCF11

1081

O94913
LQFQVTARDAGVPPL

PCDHA4

531

Q9UN74
PEPVVLNEGNQRVII

KCNA10

76

Q16322
ANGAPPRVLQQLVEE

PRRT2

211

Q7Z6L0
SEVILPVPAFNVING

ENO1

141

P06733
FERVPGPVQQALQSA

HYOU1

356

Q9Y4L1
IRPPVIAGQIVNLGQ

DOCK7

801

Q96N67
PNAFDGPITITIVNR

CD44

136

P16070
VPVLARNIPGNAAVV

GLT1D1

266

Q96MS3
VRVPPRFVVQPNNQD

DSCAML1

686

Q8TD84
QREGVLEPNPVRNFL

CCDC9

181

Q9Y3X0
FRINPDGSQSVVEVP

CNPY2

56

Q9Y2B0
PGTVQGVVRFLQLTP

CCS

96

O14618
VGGPLQNIDFTQRPF

DENND4C

1641

Q5VZ89
ENVQEIPVFGIVPAI

ADAM9

576

Q13443
DVQLPVITLNFVPGV

BPIFB6

71

Q8NFQ5
PPQPQVRFSVEQLGQ

IL12RB1

236

P42701
KVPVPRGADQVVQQE

MARCHF10

171

Q8NA82
LLPQQPVFVVQETDG

MAN2C1

671

Q9NTJ4
PVSIEPRINVGSRFQ

MIDEAS

716

Q6PJG2
VGPQGDPRVFQLQQS

FGD2

601

Q7Z6J4
QENEPTVGVIPRVIQ

KIF4A

106

O95239
QPAGQVAVLPEVQVT

KMT2A

3606

Q03164
GNVAVRLFSLQAPVP

ENGASE

476

Q8NFI3
IRPFPGLVINNQLVD

GTF2I

941

P78347
EPQSQGLSPFGQRVV

DPEP1

186

P16444
VQDVARVLGFQNPTP

PNMA1

116

Q8ND90
VFQRIPGVDPENVFI

SLC38A11

81

Q08AI6
PQVNISVQGEVPRTL

RYK

136

P34925
NPTLAQIPVVFRLAG

ECSIT

381

Q9BQ95
LFQPSIQLARQGFPV

GGT2P

156

P36268
FQGIPSNDPINVLVR

OTOF

1481

Q9HC10
FRVVAVNNIGRGPPS

PTPRD

391

P23468
PQFGGVRVVVNPRSF

RP1

46

P56715
VPQFQPIALNGRIQV

DSCAM

731

O60469
TGDVVVQAPTQVPGF

PVR

26

P15151
INPVPGQAITQIFAV

RTKN2

361

Q8IZC4
LSPFQVVVIPVGSEQ

TARS2

611

Q9BW92
TFLFQGQPVVNRPLS

TRADD

201

Q15628
LRQRFPEIPEGVVSQ

TAB3

16

Q8N5C8
VDAGLSPAQFQVRPI

RNF165

166

Q6ZSG1
TEVVVPFNQIPGNSL

PTAFR

326

P25105
FRIEPGVSVSLVNPQ

LARS1

1061

Q9P2J5
QPIFITTQGFPVRNV

POGZ

146

Q7Z3K3
VQQGQTVRPITLVPA

POGZ

176

Q7Z3K3
QVSQPFRGLIPAGTQ

PRRC2C

2631

Q9Y520
AINRAGIVQEDVQPP

SMIM20

41

Q8N5G0
QAVPQGAETPRPLFQ

SHROOM1

326

Q2M3G4
TPRGVLQERFQVLNP

SIRT4

176

Q9Y6E7
IDFNQPLVITRITPG

PDLIM3

21

Q53GG5
VEPVAQGIVSQQLPA

TSC22D1

806

Q15714
NIFVGQTESPLLVRP

SLC28A3

336

Q9HAS3
VPKQEGRTVVVVNNP

SRCAP

1001

Q6ZRS2
RNEGPLVYIQEIIPG

STXBP4

41

Q6ZWJ1
FGVPLTVNVQRTGQP

DLC1

1076

Q96QB1
SQVQEPGGVPQVFLT

SRF

446

P11831
IRIQPPSAQLEVQAG

AHNAK2

2861

Q8IVF2
DNILEGRIQVPFPTQ

AMFR

491

Q9UKV5
QEGDIGIQVLPNRPF

ACSM3

421

Q53FZ2
QTGVIIQPQQILFTG

GTF2A1

216

P52655
VRQRNPQELGVFAPT

RIN2

631

Q8WYP3
VNIAQQVVIGTPQRP

TFDP1

56

Q14186
LILIPNGVQIFFVNP

SPART

221

Q8N0X7
RQVFSVAPPFEVNGL

TTBK1

661

Q5TCY1
LRIPGTQAEFQTPIA

ZFP57

211

Q9NU63
FPANFVQRVRPGENV

STAC2

341

Q6ZMT1
RAFQEQALPVLQAGP

ZSCAN25

191

Q6NSZ9
VQVVPGSGQIIFLPF

NISCH

576

Q9Y2I1
QPVQTPFGVVTFLQI

SUFU

186

Q9UMX1
VTEIFSQIPNNGLPR

NRDC

396

O43847
DIPPIFGVQQQVARQ

TENM3

2446

Q9P273
GLPRNTVVLFVPQQE

STOML2

31

Q9UJZ1
IAIRQSVAQPLGPEN

USP20

886

Q9Y2K6
IIIPPNFQEAFQIGI

VPS13B

3016

Q7Z7G8
GSQPLQDRVLQVPVL

ZKSCAN3

176

Q9BRR0
PRFPTLGGRVVNVAQ

SLC32A1

196

Q9H598
PGLSQRQFEIVSNGP

THBS2

106

P35442
GDFRVPQILQPFING

SC5D

211

O75845
LERNIVFGINPGVAP

SLFN5

851

Q08AF3
PQVVFSDGQQRPVDP

WDR81

1456

Q562E7
IISGLFPVQQQIAPS

KIAA0586

936

Q9BVV6
LFQPSIQLARQGFPV

GGT1

156

P19440
IVQPENNRPPVAVAG

KIAA0319

616

Q5VV43
DIGPLFQTPREVAQQ

MMUT

646

P22033
QFLGALPPEIQARVQ

MZF1

91

P28698