Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	NBPF	NBPF15 NBPF9 NBPF14	2.43e-06	11	47	3	PS51316
Domain	DUF1220	NBPF15 NBPF9 NBPF14	2.43e-06	11	47	3	PF06758
Domain	NBPF_dom	NBPF15 NBPF9 NBPF14	2.43e-06	11	47	3	IPR010630
Domain	Mob1_phocein	MOB1B MOB1A	1.29e-04	7	47	2	PF03637
Domain	MOB_kinase_act_fam	MOB1B MOB1A	1.29e-04	7	47	2	IPR005301
Domain	-	MOB1B MOB1A	1.29e-04	7	47	2	1.20.140.30
Domain	Mob1_phocein	MOB1B MOB1A	1.29e-04	7	47	2	SM01388
Domain	DUF1220	NBPF15 NBPF9	2.21e-04	9	47	2	SM01148
Domain	CUB	KREMEN1 SEZ6L	6.76e-03	49	47	2	PF00431
Domain	CUB	KREMEN1 SEZ6L	7.03e-03	50	47	2	SM00042
Domain	-	KREMEN1 SEZ6L	7.59e-03	52	47	2	2.60.120.290
Domain	CUB	KREMEN1 SEZ6L	7.87e-03	53	47	2	PS01180
Domain	CUB_dom	KREMEN1 SEZ6L	9.06e-03	57	47	2	IPR000859
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF19 NBPF15 NBPF12 NBPF9 NBPF10 NBPF14 NBPF20	1.25e-15	21	52	7	16079250
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF15 NBPF12 NBPF9 NBPF14	9.27e-10	10	52	4	22973535
Pubmed	Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.	MOB1B MOB1A	2.19e-06	2	52	2	30349003
Pubmed	Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.	MOB1B MOB1A	2.19e-06	2	52	2	23143302
Pubmed	S-adenosylhomocysteine Hydrolase Participates in DNA Methylation Inheritance.	AHCY DNMT1	2.19e-06	2	52	2	29758262
Pubmed	Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.	MOB1B MOB1A	2.19e-06	2	52	2	22454515
Pubmed	Lineage-specific gene duplication and loss in human and great ape evolution.	NBPF19 ANAPC1 NBPF9 NBPF20	3.57e-06	69	52	4	15252450
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF12 ANAPC1 NBPF9 NBPF10 NBPF14	5.68e-06	170	52	5	23314748
Pubmed	DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia.	BCL2L11 DNMT1	6.57e-06	3	52	2	25389112
Pubmed	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.	MOB1B MOB1A	6.57e-06	3	52	2	34725466
Pubmed	The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.	MOB1B MOB1A	6.57e-06	3	52	2	16674920
Pubmed	AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures.	BCL2L11 PRKAA1	6.57e-06	3	52	2	26856538
Pubmed	Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK.	EPHX2 PRKAA1	6.57e-06	3	52	2	30804206
Pubmed	PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo.	MOB1B MOB1A	1.31e-05	4	52	2	30069702
Pubmed	Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.	PJA2 MOB1A	1.31e-05	4	52	2	23652010
Pubmed	Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.	MOB1B MOB1A	1.31e-05	4	52	2	15197186
Pubmed	Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs.	ALX4 HAND2	1.31e-05	4	52	2	18579682
Pubmed	YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.	MOB1B MOB1A	2.19e-05	5	52	2	32206709
Pubmed	Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.	PJA2 MOB1A	2.19e-05	5	52	2	35349706
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	ATP6V1A MOB1B AHCY MOB1A CDC5L DNMT1	2.86e-05	399	52	6	37536630
Pubmed	Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh).	ALX4 HAND2	3.28e-05	6	52	2	14727139
Pubmed	Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.	MOB1B MOB1A	3.28e-05	6	52	2	35858357
Pubmed	Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.	MOB1B MOB1A	3.28e-05	6	52	2	32716083
Pubmed	YAP determines the cell fate of injured mouse hepatocytes in vivo.	MOB1B MOB1A	3.28e-05	6	52	2	28681838
Pubmed	Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling.	ALX4 HAND2	4.58e-05	7	52	2	11850405
Pubmed	MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.	MOB1B MOB1A	4.58e-05	7	52	2	18328708
Pubmed	Molecular characterization of human homologs of yeast MOB1.	MOB1B MOB1A	6.10e-05	8	52	2	19739119
Pubmed	Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.	MOB1B MOB1A	6.10e-05	8	52	2	26699479
Pubmed	AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.	BCL2L11 PRKAA1	6.10e-05	8	52	2	20664053
Pubmed	The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud.	ALX4 HAND2	7.84e-05	9	52	2	12455637
Pubmed	Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development.	ALX4 HAND2	7.84e-05	9	52	2	16960803
Pubmed	Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.	ALX4 HAND2	9.79e-05	10	52	2	12215652
Pubmed	Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling.	BCL2L11 PRKAA1	9.79e-05	10	52	2	28847007
Pubmed	Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh.	ALX4 HAND2	9.79e-05	10	52	2	16039644
Pubmed	Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.	ALX4 HAND2	9.79e-05	10	52	2	22841643
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF15 NBPF12 NBPF9 NBPF10 CDC5L NBPF14	1.15e-04	513	52	6	25798074
Pubmed	A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.	ALX4 HAND2	1.20e-04	11	52	2	19248778
Pubmed	Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb.	ALX4 HAND2	1.20e-04	11	52	2	19386268
Pubmed	DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis.	ALX4 HAND2	1.43e-04	12	52	2	19211672
Pubmed	The molecular basis of Pallister Hall associated polydactyly.	ALX4 HAND2	1.43e-04	12	52	2	17588959
Pubmed	T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.	ALX4 HAND2	1.69e-04	13	52	2	25760946
Pubmed	Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.	ALX4 HAND2	1.69e-04	13	52	2	25448692
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	NBPF15 AHCY N4BP3 CA10 TASOR2 DNMT1	1.84e-04	560	52	6	21653829
Pubmed	Genetic interaction between Gli3 and Ezh2 during limb pattern formation.	ALX4 HAND2	1.97e-04	14	52	2	29729398
Pubmed	Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.	ANAPC1 MOB1A	1.97e-04	14	52	2	29183995
Pubmed	Sufu and Kif7 in limb patterning and development.	ALX4 HAND2	1.97e-04	14	52	2	25581370
Pubmed	Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula.	ALX4 HAND2	1.97e-04	14	52	2	23473983
Pubmed	Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival.	DNMT1 CRX	1.97e-04	14	52	2	23171847
Pubmed	Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.	MOB1B FAM135A	2.27e-04	15	52	2	20970119
Pubmed	Twist1 activity thresholds define multiple functions in limb development.	ALX4 HAND2	2.27e-04	15	52	2	20732316
Pubmed	Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle.	KREMEN1 TENT5A	2.27e-04	15	52	2	37227818
Pubmed	Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.	ALX4 HAND2	2.60e-04	16	52	2	21795281
Pubmed	Specification of jaw subdivisions by Dlx genes.	ALX4 HAND2	2.60e-04	16	52	2	12193642
Pubmed	A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.	ALX4 HAND2	2.60e-04	16	52	2	24726283
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PJA2 KLHDC2 SPIRE1 CRTC1 RAPGEF2 N4BP3 DNMT1	2.82e-04	861	52	7	36931259
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	PJA2 SESTD1 ANAPC1 ANKRD52	2.89e-04	212	52	4	33853758
Pubmed	Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.	ALX4 HAND2	2.94e-04	17	52	2	24726282
Pubmed	The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly.	ALX4 HAND2	3.30e-04	18	52	2	12413903
Pubmed	Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway.	ALX4 HAND2	3.30e-04	18	52	2	24424161
Pubmed	Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development.	ALX4 HAND2	3.30e-04	18	52	2	27352137
Pubmed	Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton.	ALX4 HAND2	3.30e-04	18	52	2	22178153
Pubmed	MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation.	MOB1B MOB1A	3.30e-04	18	52	2	28346423
Pubmed	Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.	ALX4 HAND2	3.30e-04	18	52	2	20386744
Pubmed	Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.	ALX4 HAND2	4.09e-04	20	52	2	24218595
Pubmed	FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.	ALX4 HAND2	4.52e-04	21	52	2	19386269
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NBPF19 NBPF9 NBPF14 NBPF20 TASOR2	4.55e-04	430	52	5	35044719
Pubmed	Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.	ATP6V1A PJA2 KLHDC2 PRKAA1 AHCY	4.65e-04	432	52	5	7671812
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FNDC3A TBCD SEZ6L	4.88e-04	102	52	3	10231032
Pubmed	Mesodermal Tbx1 is required for patterning the proximal mandible in mice.	ALX4 HAND2	4.97e-04	22	52	2	20501333
Pubmed	Hedgehog signaling patterns the oral-aboral axis of the mandibular arch.	ALX4 HAND2	4.97e-04	22	52	2	30638444
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	ANAPC1 MOB1B MOB1A RAPGEF2 ANKRD52	5.37e-04	446	52	5	24255178
Pubmed	Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.	ALX4 HAND2	5.44e-04	23	52	2	16672333
Pubmed	TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development.	ALX4 HAND2	5.44e-04	23	52	2	38828908
Pubmed	Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos.	ALX4 HAND2	6.43e-04	25	52	2	22438573
Pubmed	NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition.	PRKAA1 DNMT1	6.43e-04	25	52	2	37493331
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	AHCY FNDC3A	6.43e-04	25	52	2	35211260
Pubmed	GATA6 is a crucial regulator of Shh in the limb bud.	ALX4 HAND2	6.96e-04	26	52	2	24415953
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	GUCY1B1 MOB1B MOB1A RAPGEF2	7.18e-04	270	52	4	24366813
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	PRKAA1 ANKRD52 ALX4	8.02e-04	121	52	3	31900314
Pubmed	Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.	MOB1B MOB1A	8.08e-04	28	52	2	37846569
Pubmed	Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway.	ALX4 HAND2	8.67e-04	29	52	2	26959361
Pubmed	Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.	ALX4 HAND2	9.29e-04	30	52	2	38404688
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	ANAPC1 PRKAA1 MOB1A	9.65e-04	129	52	3	23022380
Pubmed	The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.	PRKAA1 HAND2	1.49e-03	38	52	2	33913477
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	NBPF19 NBPF15 NBPF12 NBPF9 NBPF10 NBPF14 NBPF20	3.69e-07	404	52	7	chr1q21
Cytoband	1q21.1	NBPF9 NBPF10 NBPF14	4.94e-05	62	52	3	1q21.1
Cytoband	22q12.1	KREMEN1 SEZ6L	6.11e-04	32	52	2	22q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q13	BCL2L11 ANAPC1	2.07e-03	59	52	2	chr2q13
Cytoband	1q21.2	NBPF15 NBPF20	2.97e-03	71	52	2	1q21.2
GeneFamily	Neuroblastoma breakpoint family	NBPF19 NBPF15 NBPF12 NBPF9 NBPF10 NBPF26 NBPF14 NBPF20	5.14e-17	23	36	8	662
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB1B MOB1A	8.04e-05	7	36	2	647
ToppCell	COVID-19_Convalescent\|World / Disease condition and Cell class	NBPF19 NBPF15 NBPF26 NBPF14 NBPF20	2.22e-06	181	52	5	a62115a8da486fc61225901c72b1ec70bcaf4c36
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBPF19 EPHX2 NBPF10 NBPF26 ABCG5	3.20e-06	195	52	5	e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NBPF19 NBPF10 NBPF26 CA10 NBPF14	3.62e-06	200	52	5	f75d95376a340d467c4392b872b2a2dbdd184556
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NBPF19 NBPF10 NBPF26 CA10 NBPF14	3.62e-06	200	52	5	47791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NBPF19 NBPF10 NBPF26 CA10 NBPF14	3.62e-06	200	52	5	fae26560ba3b0b638b6bcf92f05330824b31d21b
ToppCell	Control-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF15 NBPF12 NBPF10 SLC45A2	2.42e-05	144	52	4	984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNG1 ST6GALNAC5 HAND2 SEZ6L	3.14e-05	154	52	4	30cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNG1 ST6GALNAC5 HAND2 SEZ6L	3.14e-05	154	52	4	ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNG1 ST6GALNAC5 HAND2 SEZ6L	3.14e-05	154	52	4	42bd8f88fd075a2d4edde394785decad88a2660a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNG1 ST6GALNAC5 HAND2 SEZ6L	3.14e-05	154	52	4	6425d9861148586466febd6eceae1b1f9b9a14c1
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF15 NBPF12 NBPF10 SLC45A2	4.31e-05	167	52	4	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NBPF19 NBPF10 CA10 NBPF14	4.95e-05	173	52	4	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBPF19 NBPF10 NBPF26 ABCG5	5.77e-05	180	52	4	7c7c4d64ff99d0710a7d19d8bc29fc9217394db1
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBPF19 NBPF9 NBPF10 NBPF26	5.77e-05	180	52	4	b234668bf181522807470e396792e1b54890b719
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SESTD1 SPIRE1 CA10 FAM135A	6.03e-05	182	52	4	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SESTD1 SPIRE1 CA10 FAM135A	6.69e-05	187	52	4	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG1 KCNG1 TENT5A SEZ6L	6.69e-05	187	52	4	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG1 KCNG1 TENT5A SEZ6L	6.83e-05	188	52	4	ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	NBPF19 NBPF10 NBPF26 NBPF14	6.98e-05	189	52	4	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 GABRG1 ST6GALNAC5 SPIRE1	7.27e-05	191	52	4	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SESTD1 ZPLD1 FNDC3A SLC45A2	7.56e-05	193	52	4	ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCell	COVID-19_Convalescent-PLT_4\|COVID-19_Convalescent / Disease Group and Platelet Clusters	KLHDC2 MOB1B CD69 CDC5L	7.72e-05	194	52	4	ce1fad4e76a87f0c35e430ed1f2262395df882fd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZPLD1 SPIRE1 FNDC3A FAM135A	7.72e-05	194	52	4	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZPLD1 SPIRE1 FNDC3A FAM135A	7.72e-05	194	52	4	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 GABRG1 NBPF10 NBPF26	8.68e-05	200	52	4	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 GABRG1 NBPF10 NBPF26	8.68e-05	200	52	4	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 GABRG1 NBPF10 NBPF26	8.68e-05	200	52	4	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GABRG1 KCNG1 TENT5A SEZ6L	8.68e-05	200	52	4	c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCell	COVID-19-COVID-19_Convalescent-Lymphocyte-B-B_naive\|COVID-19_Convalescent / Disease, condition lineage and cell class	SESTD1 KCNG1 CD69 N4BP3	8.68e-05	200	52	4	5c1b51b9571681d8b792d1443d9f8926dcd55b29
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 GABRG1 NBPF10 NBPF26	8.68e-05	200	52	4	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GABRG1 KCNG1 TENT5A SEZ6L	8.68e-05	200	52	4	ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 GABRG1 NBPF10 NBPF26	8.68e-05	200	52	4	01819446deeab9054f5cfe889d53bb49d137dbc0
Drug	Pesticides	NBPF15 NBPF12 GUCY1B1 NBPF9 NBPF10 NBPF14 NBPF20	3.69e-08	150	50	7	ctd:D010575
Disease	alcohol consumption measurement, waist-hip ratio	ZPLD1 CRTC1	1.36e-05	4	45	2	EFO_0004343, EFO_0007878
Disease	synophrys measurement	SLC45A2 CDC5L ALX4	1.55e-04	68	45	3	EFO_0007906
Disease	uterine fibroid	GABRG1 GUCY1B1 FNDC3A PGBD2	2.41e-04	199	45	4	EFO_0000731
Disease	otosclerosis	ANAPC1 CRTC1 DNMT1	2.60e-04	81	45	3	EFO_0004213
Disease	lymphocyte:monocyte ratio	BCL2L11 TENT5A CD69 CDC5L	9.67e-04	288	45	4	EFO_0600088
Disease	Arthritis, Experimental	CD69 DNMT1	1.71e-03	40	45	2	C0993582
Disease	Arthritis, Adjuvant-Induced	CD69 DNMT1	1.71e-03	40	45	2	C0003865
Disease	Arthritis, Collagen-Induced	CD69 DNMT1	1.71e-03	40	45	2	C0971858
Disease	virologic response measurement, response to abacavir	PJA2 ALX4	1.88e-03	42	45	2	EFO_0006905, EFO_0006906
Disease	lung non-small cell carcinoma (is_marker_for)	SOX30 PRKAA1 DNMT1	2.20e-03	169	45	3	DOID:3908 (is_marker_for)
Disease	response to hydrochlorothiazide, triglyceride measurement	TENT5A DNMT1	2.35e-03	47	45	2	EFO_0004530, EFO_0005202
Disease	hair colour measurement	KREMEN1 SLC45A2 TRAPPC2L ALX4 TBCD	2.38e-03	615	45	5	EFO_0007822
Disease	cholestasis (biomarker_via_orthology)	PRKAA1 ABCG5	2.56e-03	49	45	2	DOID:13580 (biomarker_via_orthology)
Disease	glucose-dependent insulinotropic peptide measurement	TENT5A TBCD	2.98e-03	53	45	2	EFO_0008464

Protein segments in the cluster

Peptide	Gene	Start	Entry
ESPAAAMDAYYSPVS	ALX4	11	Q9H161
NPEDGMADYSDPSYV	CDC5L	451	Q99459
TSFAEYILMDPSPEY	DNMT1	481	P26358
YFSFDTDRSPAPMSC	BCL2L11	96	O43521
DPLDAGVDYSGYSPM	ANKRD52	781	Q8NB46
PGPEMEYCTDRESYS	ANAPC1	1281	Q9H1A4
YNCPGQYTFSMPSDS	CD69	66	Q07108
DPTICGYNFDPKTYM	FAM135A	551	Q9P2D6
MSSVVYSPDFPDTYA	KREMEN1	221	Q96MU8
EYTYRCLMSPENSDP	GUCY1B1	566	Q02153
EMADSPEFTSIPACY	KCNG1	401	Q9UIX4
EESCPVMSAGPKYEY	MOB1B	81	Q7L9L4
PDYSMALSYSPEYAS	HAND2	56	P61296
YGESSAPPEIEEYCM	EPHX2	296	P34913
PMDEHSCPLEFSSYG	GABRG1	196	Q8N1C3
RQADSCPYGTMYLSP	CRTC1	126	Q6UUV9
EEVLYYTSGCAPSMP	FNDC3A	456	Q9Y2H6
TPAEMLDFFNDCGYP	ABCG5	276	Q9H222
PAFESYESMELACPA	KLHDC2	16	Q9Y2U9
GAPGTLMTAPEYYEF	DALRD3	321	Q5D0E6
SYKCSMEQGLYPTFP	DALRD3	416	Q5D0E6
SFITYDGSMTIPPCY	CA10	231	Q9NS85
YLGMSCDGPFKPDHY	AHCY	416	P23526
QDPPLSSDGMYEYGS	SLC45A2	256	Q9UMX9
YAMTYAPASAFCSSP	CRX	191	O43186
SYTDVMCNPFYNPGD	TRAPPC2L	106	Q9UL33
YLPGESLTFMCYEGF	SEZ6L	891	Q9BYH1
FGEMGLDYSYKCTTP	TATDN2	591	Q93075
LCYYLSPPESMGAIF	SEC61A2	341	Q9H9S3
QDSLDGCYSTPSMYF	NBPF9	1046	P0DPF3
GCYSTPSMYFELPDS	NBPF9	1051	P0DPF3
CYSTPSMYFELPDSF	NBPF10	3736	Q6P3W6
DRCYSTPSMYFELPD	NBPF12	1396	Q5TAG4
ICYSTPSMYFELPDS	NBPF14	861	Q5TI25
CYSTPSMYFEQPDSF	NBPF15	611	Q8N660
LDGCYSTPSMYFELP	NBPF19	3781	A0A087WUL8
DGCYSTPSMYFELPD	NBPF20	5146	P0DPF2
DICYSTPSMYFELPD	NBPF26	841	B4DH59
EASCPVMSAGPRYEY	MOB1A	81	Q9H8S9
YYEPFGPDECTMYLS	ST6GALNAC5	271	Q9BVH7
FPSSMPECLSYYEDR	SOX30	641	O94993
YPDGTEQYFGSPSDM	SESTD1	651	Q86VW0
YLFPEDPSYSSTMID	PRKAA1	286	Q13131
PLEEFYSFGESMCEY	PGBD2	261	Q6P3X8
EPDQYSLGSYAPMSE	RAPGEF2	1196	Q9Y4G8
LMDYCYTTPSGNPND	ZPLD1	231	Q8TCW7
YGDTVMYGLESSPCS	SLC36A1	116	Q7Z2H8
FYMSSPGPSEYCPSE	SPIRE1	736	Q08AE8
AEMPADSGYPAYLGA	ATP6V1A	366	P38606
LCSEYYMKEPGEADP	TBCD	736	Q9BTW9
EMYLPFPGRSASYED	TASOR2	2146	Q5VWN6
GYFAMSEDELACSPY	TENT5A	6	Q96IP4
EYDGEHDCMFLDPPY	PJA2	366	O43164
PPYEFSCSSAEEMGA	N4BP3	246	O15049