Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontestosterone 6-beta-hydroxylase activity

CYP3A7 CYP3A4 CYP3A5

2.20e-085273GO:0050649
GeneOntologyMolecularFunctionestrogen 2-hydroxylase activity

CYP3A7 CYP3A4 CYP3A5

1.23e-078273GO:0101021
GeneOntologyMolecularFunctionestrogen 16-alpha-hydroxylase activity

CYP3A7 CYP3A4 CYP3A5

3.61e-0711273GO:0101020
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP3A7 CYP3A4 CYP3A5

7.95e-0714273GO:0008401
GeneOntologyMolecularFunctionglycine-gated chloride ion channel activity

GLRA3 GLRA2

1.76e-062272GO:0022852
GeneOntologyMolecularFunctionvasoactive intestinal polypeptide receptor activity

VIPR1 ADCYAP1R1

5.28e-063272GO:0004999
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GLRA3 P2RX2 GLRA2 CNGB3 TTYH2

5.44e-06193275GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GLRA3 P2RX2 GLRA2 CNGB3 TTYH2

6.01e-06197275GO:0022834
GeneOntologyMolecularFunctiontestosterone 16-alpha-hydroxylase activity

CYP3A4 CYP3A5

1.05e-054272GO:0008390
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP3A7 CYP3A4 CYP3A5

1.28e-0534273GO:0008395
GeneOntologyMolecularFunctionaromatase activity

CYP3A7 CYP3A4 CYP3A5

1.40e-0535273GO:0070330
GeneOntologyMolecularFunctionoxygen binding

CYP3A7 CYP3A4 CYP3A5

1.66e-0537273GO:0019825
GeneOntologyMolecularFunctionvitamin D 23-hydroxylase activity

CYP3A4 CYP3A5

1.76e-055272GO:0062179
GeneOntologyMolecularFunction1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity

CYP3A4 CYP3A5

1.76e-055272GO:0062181
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

GLRA3 P2RX2 GLRA2

2.62e-0543273GO:0005231
GeneOntologyMolecularFunctionvitamin D 24-hydroxylase activity

CYP3A4 CYP3A5

2.63e-056272GO:0070576
GeneOntologyMolecularFunctionvitamin D3 25-hydroxylase activity

CYP3A4 CYP3A5

2.63e-056272GO:0030343
GeneOntologyMolecularFunctionextracellularly glycine-gated ion channel activity

GLRA3 GLRA2

2.63e-056272GO:0016933
GeneOntologyMolecularFunctionextracellularly glycine-gated chloride channel activity

GLRA3 GLRA2

2.63e-056272GO:0016934
GeneOntologyMolecularFunctionvitamin D 25-hydroxylase activity

CYP3A4 CYP3A5

3.68e-057272GO:0070643
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP3A7 CYP3A4 CYP3A5

3.90e-0549273GO:0016712
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GLRA3 GLRA2 TTYH2

4.14e-0550273GO:0099095
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

CYP3A4 CYP3A5

4.91e-058272GO:0033695
GeneOntologyMolecularFunctioncaffeine oxidase activity

CYP3A4 CYP3A5

4.91e-058272GO:0034875
GeneOntologyMolecularFunctioninhibitory extracellular ligand-gated monoatomic ion channel activity

GLRA3 GLRA2

4.91e-058272GO:0005237
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GLRA3 SLC8B1 P2RX2 SLC34A1 GLRA2 CNGB3 TTYH2

6.71e-05793277GO:0015075
GeneOntologyMolecularFunctiongated channel activity

GLRA3 P2RX2 GLRA2 CNGB3 TTYH2

7.58e-05334275GO:0022836
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GLRA3 SLC34A1 GLRA2 TTYH2

7.81e-05171274GO:0015103
GeneOntologyMolecularFunctiontransmembrane transporter activity

GLRA3 SLC8B1 P2RX2 SLC34A1 ABCA9 GLRA2 CNGB3 TTYH2

1.17e-041180278GO:0022857
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GLRA3 P2RX2 GLRA2

1.51e-0477273GO:0005230
GeneOntologyMolecularFunctionglycine binding

GLRA3 GLRA2

1.59e-0414272GO:0016594
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP3A4 CYP3A5

1.83e-0415272GO:0016725
GeneOntologyMolecularFunctionchloride channel activity

GLRA3 GLRA2 TTYH2

2.09e-0486273GO:0005254
GeneOntologyMolecularFunctiontransporter activity

GLRA3 SLC8B1 P2RX2 SLC34A1 ABCA9 GLRA2 CNGB3 TTYH2

2.17e-041289278GO:0005215
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

GLRA3 CCR2 GPR83 VIPR1 OR11L1 P2RX2 ADCYAP1R1 GLRA2

3.02e-041353278GO:0004888
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GLRA3 P2RX2 GLRA2 CNGB3 TTYH2

3.34e-04459275GO:0005216
GeneOntologyMolecularFunctionmonoatomic anion channel activity

GLRA3 GLRA2 TTYH2

3.56e-04103273GO:0005253
GeneOntologyMolecularFunctionmonooxygenase activity

CYP3A7 CYP3A4 CYP3A5

4.92e-04115273GO:0004497
GeneOntologyMolecularFunctionchannel activity

GLRA3 P2RX2 GLRA2 CNGB3 TTYH2

6.16e-04525275GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GLRA3 P2RX2 GLRA2 CNGB3 TTYH2

6.22e-04526275GO:0022803
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

GLRA3 GLRA2 TTYH2

6.28e-04125273GO:0015108
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

GPR83 VIPR1 ADCYAP1R1

7.52e-04133273GO:0008528
GeneOntologyMolecularFunctionpeptide receptor activity

GPR83 VIPR1 ADCYAP1R1

8.72e-04140273GO:0001653
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GLRA3 GLRA2 TTYH2

1.09e-03151273GO:0008509
GeneOntologyMolecularFunctionheme binding

CYP3A7 CYP3A4 CYP3A5

1.15e-03154273GO:0020037
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP3A7 CYP3A4 CYP3A5

1.38e-03164273GO:0046906
GeneOntologyMolecularFunctioniron ion binding

CYP3A7 CYP3A4 CYP3A5

1.43e-03166273GO:0005506
GeneOntologyMolecularFunctiondemethylase activity

CYP3A4 CYP3A5

1.61e-0344272GO:0032451
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP3A7 CYP3A4 CYP3A5

2.22e-03194273GO:0016705
GeneOntologyMolecularFunctionpeptide hormone binding

VIPR1 ADCYAP1R1

2.50e-0355272GO:0017046
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GLRA3 SLC8B1 SLC34A1 GLRA2 TTYH2

3.13e-03758275GO:0015318
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GLRA3 GLRA2

3.47e-0365272GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GLRA3 GLRA2

3.47e-0365272GO:0022824
GeneOntologyMolecularFunctionamino acid binding

GLRA3 GLRA2

4.36e-0373272GO:0016597
GeneOntologyMolecularFunctionorganic acid binding

GLRA3 P2RX2 GLRA2

4.75e-03254273GO:0043177
GeneOntologyMolecularFunctionG protein-coupled receptor activity

CCR2 GPR83 VIPR1 OR11L1 ADCYAP1R1

6.03e-03884275GO:0004930
GeneOntologyMolecularFunctionamide binding

VIPR1 P2RX2 ADCYAP1R1

7.45e-03299273GO:0033218
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GLRA3 GLRA2

8.03e-03100272GO:0030594
GeneOntologyMolecularFunctionhormone binding

VIPR1 ADCYAP1R1

8.50e-03103272GO:0042562
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC8B1 P2RX2 SLC34A1 CNGB3

1.16e-02664274GO:0008324
GeneOntologyMolecularFunctionsteroid binding

CYP3A4 CYP3A5

1.39e-02133272GO:0005496
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

P2RX2 CNGB3

1.53e-02140272GO:0099094
GeneOntologyMolecularFunctionoxidoreductase activity

CYP3A7 LBR CYP3A4 CYP3A5

1.87e-02766274GO:0016491
GeneOntologyMolecularFunctiontransition metal ion binding

CYP3A7 CYP3A4 P2RX2 CYP3A5 UBR4

2.00e-021189275GO:0046914
GeneOntologyBiologicalProcesslipid hydroxylation

CYP3A7 CYP3A4 CYP3A5

1.49e-079263GO:0002933
GeneOntologyBiologicalProcessoxidative demethylation

CYP3A7 CYP3A4 CYP3A5

3.88e-0712263GO:0070989
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

GLRA3 CCR2 SLC8B1 P2RX2 SLC34A1 ADCYAP1R1 GLRA2 HTT CNGB3 TTYH2

4.91e-0711152610GO:0034220
GeneOntologyBiologicalProcessmonoatomic ion transport

GLRA3 CCR2 SLC8B1 P2RX2 SLC34A1 ADCYAP1R1 GLRA2 HTT CNGB3 TTYH2

3.30e-0613742610GO:0006811
GeneOntologyBiologicalProcessdemethylation

CYP3A7 CYP3A4 CYP3A5

3.54e-0624263GO:0070988
GeneOntologyBiologicalProcessalcohol metabolic process

CYP3A7 LBR CYP3A4 CYP3A5 SLC34A1 ADCYAP1R1

1.00e-05412266GO:0006066
GeneOntologyBiologicalProcessorganic hydroxy compound metabolic process

CYP3A7 LBR CYP3A4 CYP3A5 SLC34A1 ADCYAP1R1 HTT

1.06e-05641267GO:1901615
GeneOntologyBiologicalProcessalkaloid catabolic process

CYP3A4 CYP3A5

1.52e-055262GO:0009822
GeneOntologyBiologicalProcessretinoic acid metabolic process

CYP3A7 CYP3A4 CYP3A5

1.70e-0540263GO:0042573
GeneOntologyBiologicalProcesspositive regulation of transmembrane transport

CCR2 P2RX2 SLC34A1 ADCYAP1R1 HTT

2.05e-05273265GO:0034764
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

GLRA3 SLC34A1 GLRA2 TTYH2

2.28e-05134264GO:0098661
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

GLRA3 SLC8B1 P2RX2 SLC34A1 ADCYAP1R1 GLRA2 HTT TTYH2

2.40e-051017268GO:0098660
GeneOntologyBiologicalProcessestrogen metabolic process

CYP3A7 CYP3A4 CYP3A5

3.77e-0552263GO:0008210
GeneOntologyBiologicalProcessretinol metabolic process

CYP3A7 CYP3A4 CYP3A5

3.99e-0553263GO:0042572
GeneOntologyBiologicalProcessmycotoxin metabolic process

CYP3A4 CYP3A5

4.26e-058262GO:0043385
GeneOntologyBiologicalProcessaflatoxin metabolic process

CYP3A4 CYP3A5

4.26e-058262GO:0046222
GeneOntologyBiologicalProcessorganic heteropentacyclic compound metabolic process

CYP3A4 CYP3A5

4.26e-058262GO:1901376
GeneOntologyBiologicalProcessalkaloid metabolic process

CYP3A4 CYP3A5

5.47e-059262GO:0009820
GeneOntologyBiologicalProcessinorganic anion transport

GLRA3 SLC34A1 GLRA2 TTYH2

7.22e-05180264GO:0015698
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transmembrane transport

CCR2 P2RX2 ADCYAP1R1 HTT

9.27e-05192264GO:0034767
GeneOntologyBiologicalProcesscalcium ion homeostasis

CCR2 SLC8B1 P2RX2 SLC34A1 HTT

1.10e-04389265GO:0055074
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

SLC8B1 P2RX2 ADCYAP1R1 HTT

1.49e-04217264GO:0097553
GeneOntologyBiologicalProcessretinoid metabolic process

CYP3A7 CYP3A4 CYP3A5

1.88e-0489263GO:0001523
GeneOntologyBiologicalProcesstoxin metabolic process

CYP3A4 CYP3A5

2.05e-0417262GO:0009404
GeneOntologyBiologicalProcessditerpenoid metabolic process

CYP3A7 CYP3A4 CYP3A5

2.21e-0494263GO:0016101
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

CCR2 GPR83 VIPR1 OR11L1 ADCY3 ADCYAP1R1 GLRA2 HTT

2.23e-041395268GO:0007186
GeneOntologyBiologicalProcessterpenoid metabolic process

CYP3A7 CYP3A4 CYP3A5

3.06e-04105263GO:0006721
GeneOntologyBiologicalProcessprimary alcohol metabolic process

CYP3A7 CYP3A4 CYP3A5

3.15e-04106263GO:0034308
GeneOntologyBiologicalProcesspositive regulation of calcium ion transport into cytosol

P2RX2 ADCYAP1R1

3.16e-0421262GO:0010524
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transport

CCR2 P2RX2 ADCYAP1R1 HTT

3.23e-04266264GO:0043270
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport

P2RX2 ADCYAP1R1 HTT

3.42e-04109263GO:1904427
GeneOntologyBiologicalProcesschloride transmembrane transport

GLRA3 GLRA2 TTYH2

3.70e-04112263GO:1902476
GeneOntologyBiologicalProcessorganic hydroxy compound biosynthetic process

LBR CYP3A4 ADCYAP1R1 HTT

3.77e-04277264GO:1901617
GeneOntologyBiologicalProcesshormone metabolic process

CYP3A7 CYP3A4 CYP3A5 HTT

4.25e-04286264GO:0042445
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

CYP3A7 CYP3A4 CYP3A5 SLC34A1 ADCYAP1R1

4.43e-04525265GO:0009410
GeneOntologyBiologicalProcesscellular response to ethanol

GLRA3 GLRA2

4.50e-0425262GO:0071361
GeneOntologyBiologicalProcesspolyol metabolic process

CYP3A4 SLC34A1 ADCYAP1R1

4.87e-04123263GO:0019751
GeneOntologyBiologicalProcessregulation of calcium ion transport into cytosol

P2RX2 ADCYAP1R1

5.26e-0427262GO:0010522
GeneOntologyBiologicalProcesschloride transport

GLRA3 GLRA2 TTYH2

5.47e-04128263GO:0006821
GeneOntologyBiologicalProcesscellular response to zinc ion

GLRA3 GLRA2

5.66e-0428262GO:0071294
GeneOntologyBiologicalProcessexcitatory postsynaptic potential

GLRA3 P2RX2 GLRA2

5.72e-04130263GO:0060079
GeneOntologyBiologicalProcesscellular response to alcohol

GLRA3 ADCY3 GLRA2

5.72e-04130263GO:0097306
GeneOntologyBiologicalProcessregulation of membrane potential

GLRA3 SLC8B1 P2RX2 SLC34A1 GLRA2

5.89e-04559265GO:0042391
GeneOntologyBiologicalProcessresponse to alcohol

GLRA3 ADCY3 ADCYAP1R1 GLRA2

5.90e-04312264GO:0097305
GeneOntologyBiologicalProcessregulation of calcium ion transport

SLC8B1 P2RX2 ADCYAP1R1 HTT

6.72e-04323264GO:0051924
GeneOntologyBiologicalProcessregulation of monoatomic ion transport

CCR2 SLC8B1 P2RX2 ADCYAP1R1 HTT

6.80e-04577265GO:0043269
GeneOntologyBiologicalProcessregulation of lymphocyte chemotaxis

CCR2 SLC8B1

6.95e-0431262GO:1901623
GeneOntologyBiologicalProcessxenobiotic metabolic process

CYP3A7 CYP3A4 CYP3A5

7.25e-04141263GO:0006805
GeneOntologyBiologicalProcessregulation of transmembrane transport

CCR2 P2RX2 SLC34A1 ADCYAP1R1 HTT

7.47e-04589265GO:0034762
GeneOntologyBiologicalProcessisoprenoid metabolic process

CYP3A7 CYP3A4 CYP3A5

7.70e-04144263GO:0006720
GeneOntologyBiologicalProcesschemical synaptic transmission, postsynaptic

GLRA3 P2RX2 GLRA2

8.18e-04147263GO:0099565
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

GLRA3 GLRA2 TTYH2

9.18e-04153263GO:0098656
GeneOntologyBiologicalProcessalcohol biosynthetic process

LBR CYP3A4 ADCYAP1R1

9.36e-04154263GO:0046165
GeneOntologyBiologicalProcesspositive regulation of calcium ion transport

P2RX2 ADCYAP1R1 HTT

9.36e-04154263GO:0051928
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC8B1 P2RX2 SLC34A1 ADCYAP1R1 HTT CNGB3

9.36e-04942266GO:0098655
GeneOntologyBiologicalProcessinorganic ion homeostasis

CCR2 SLC8B1 P2RX2 SLC34A1 HTT

9.54e-04622265GO:0098771
GeneOntologyBiologicalProcessxenobiotic catabolic process

CYP3A4 CYP3A5

9.90e-0437262GO:0042178
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CCR2 SLC8B1 P2RX2 HTT

9.97e-04359264GO:0006874
GeneOntologyBiologicalProcessresponse to ethanol

GLRA3 ADCYAP1R1 GLRA2

1.06e-03161263GO:0045471
GeneOntologyBiologicalProcesssteroid metabolic process

CYP3A7 LBR CYP3A4 CYP3A5

1.18e-03376264GO:0008202
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

GLRA3 CCR2 P2RX2 GLRA2 HTT

1.27e-03663265GO:0050804
GeneOntologyBiologicalProcesscalcium ion transport into cytosol

P2RX2 ADCYAP1R1

1.28e-0342262GO:0060402
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

GLRA3 CCR2 P2RX2 GLRA2 HTT

1.28e-03664265GO:0099177
GeneOntologyBiologicalProcesspositive regulation of cation transmembrane transport

P2RX2 ADCYAP1R1 HTT

1.33e-03174263GO:1904064
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

SLC8B1 P2RX2 ADCYAP1R1 HTT

1.38e-03392264GO:0070588
GeneOntologyBiologicalProcesssmall molecule biosynthetic process

LBR CYP3A4 ADCYAP1R1 HTT UBR4

1.38e-03676265GO:0044283
GeneOntologyBiologicalProcessregulation of hormone levels

CYP3A7 SLC8B1 CYP3A4 CYP3A5 HTT

1.46e-03684265GO:0010817
GeneOntologyBiologicalProcessregulation of postsynaptic membrane potential

GLRA3 P2RX2 GLRA2

1.47e-03180263GO:0060078
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP3A7 CYP3A4 CYP3A5

1.47e-03180263GO:0120254
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

CYP3A7 CYP3A4 CYP3A5 SLC34A1 HTT UBR4

1.52e-031035266GO:0019752
GeneOntologyBiologicalProcessmonoatomic anion transport

GLRA3 GLRA2 TTYH2

1.54e-03183263GO:0006820
GeneOntologyBiologicalProcessresponse to organic cyclic compound

GPR83 P2RX2 SLC34A1 ADCY3 ADCYAP1R1 HTT

1.63e-031048266GO:0014070
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

CCR2 SLC8B1 P2RX2 SLC34A1 HTT

1.67e-03705265GO:0055080
GeneOntologyBiologicalProcessresponse to metal ion

GLRA3 SLC34A1 GLRA2 HTT

1.70e-03415264GO:0010038
GeneOntologyBiologicalProcessoxoacid metabolic process

CYP3A7 CYP3A4 CYP3A5 SLC34A1 HTT UBR4

1.71e-031058266GO:0043436
GeneOntologyBiologicalProcessregulation of monoatomic ion transmembrane transport

CCR2 P2RX2 ADCYAP1R1 HTT

1.73e-03417264GO:0034765
GeneOntologyBiologicalProcessorganic acid metabolic process

CYP3A7 CYP3A4 CYP3A5 SLC34A1 HTT UBR4

1.76e-031064266GO:0006082
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CCR2 SLC8B1 P2RX2 SLC34A1 HTT

1.79e-03717265GO:0050801
GeneOntologyBiologicalProcesssensory perception

CCR2 OR11L1 P2RX2 CLRN3 ADCY3 CNGB3

1.82e-031072266GO:0007600
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

CYP3A7 CYP3A4 CYP3A5 HTT UBR4

1.95e-03731265GO:0032787
GeneOntologyBiologicalProcesslymphocyte chemotaxis

CCR2 SLC8B1

2.02e-0353262GO:0048247
GeneOntologyBiologicalProcesssteroid biosynthetic process

CYP3A7 LBR CYP3A4

2.25e-03209263GO:0006694
GeneOntologyBiologicalProcesslipid modification

CYP3A7 CYP3A4 CYP3A5

2.40e-03214263GO:0030258
GeneOntologyBiologicalProcessregulation of adenylate cyclase activity

CCR2 ADCY3

2.50e-0359262GO:0045761
GeneOntologyCellularComponentchloride channel complex

GLRA3 GLRA2 TTYH2

5.37e-0557273GO:0034707
GeneOntologyCellularComponentglycinergic synapse

GLRA3 GLRA2

3.01e-0420272GO:0098690
DomainCyt_P450_E_grp-II

CYP3A7 CYP3A4 CYP3A5

2.69e-085273IPR002402
DomainCyt_P450_E_CYP3A

CYP3A7 CYP3A4 CYP3A5

5.37e-086273IPR008072
DomainGlycine_rcpt_A

GLRA3 GLRA2

1.21e-054272IPR008127
DomainCyt_P450_CS

CYP3A7 CYP3A4 CYP3A5

6.01e-0553273IPR017972
DomainCYTOCHROME_P450

CYP3A7 CYP3A4 CYP3A5

7.48e-0557273PS00086
Domainp450

CYP3A7 CYP3A4 CYP3A5

7.88e-0558273PF00067
DomainCyt_P450

CYP3A7 CYP3A4 CYP3A5

8.73e-0560273IPR001128
DomainGABAA/Glycine_rcpt

GLRA3 GLRA2

5.00e-0423272IPR006028
DomainHormR

VIPR1 ADCYAP1R1

5.92e-0425272SM00008
DomainHRM

VIPR1 ADCYAP1R1

7.43e-0428272PF02793
DomainGPCR_2_secretin-like_CS

VIPR1 ADCYAP1R1

1.10e-0334272IPR017983
DomainG_PROTEIN_RECEP_F2_1

VIPR1 ADCYAP1R1

1.52e-0340272PS00649
DomainG_PROTEIN_RECEP_F2_3

VIPR1 ADCYAP1R1

1.52e-0340272PS50227
DomainGPCR_2_extracellular_dom

VIPR1 ADCYAP1R1

1.52e-0340272IPR001879
DomainCyt_P450_E_grp-I

CYP3A7 CYP3A5

1.92e-0345272IPR002401
DomainNeurotransmitter_ion_chnl_CS

GLRA3 GLRA2

1.92e-0345272IPR018000
DomainNeur_chan_memb

GLRA3 GLRA2

2.00e-0346272PF02932
DomainNeur_chan_LBD

GLRA3 GLRA2

2.09e-0347272PF02931
DomainNeur_channel

GLRA3 GLRA2

2.09e-0347272IPR006201
DomainNeur_chan_lig-bd

GLRA3 GLRA2

2.09e-0347272IPR006202
DomainNeurotrans-gated_channel_TM

GLRA3 GLRA2

2.09e-0347272IPR006029
DomainNEUROTR_ION_CHANNEL

GLRA3 GLRA2

2.09e-0347272PS00236
Domain-

GLRA3 GLRA2

2.09e-03472722.70.170.10
DomainHEAT

HEATR1 HTT

2.18e-0348272PF02985
Domain7tm_2

VIPR1 ADCYAP1R1

2.36e-0350272PF00002
DomainG_PROTEIN_RECEP_F2_2

VIPR1 ADCYAP1R1

2.36e-0350272PS00650
Domain-

CYP3A4 CYP3A5

3.16e-03582721.10.630.10
DomainHEAT

HEATR1 HTT

3.16e-0358272IPR000357
DomainGPCR_2-like

VIPR1 ADCYAP1R1

3.38e-0360272IPR017981
DomainGPCR_2_secretin-like

VIPR1 ADCYAP1R1

3.38e-0360272IPR000832
DomainG_PROTEIN_RECEP_F2_4

VIPR1 ADCYAP1R1

3.49e-0361272PS50261
DomainHEAT_REPEAT

HEATR1 HTT

4.57e-0370272PS50077
Domain7TM_GPCR_Srsx

CCR2 GPR83

1.13e-02112272SM01381
DomainARM-type_fold

HEATR1 HTT UBR4

1.26e-02339273IPR016024
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

GLRA3 GPR83 VIPR1 P2RX2 ADCYAP1R1 GLRA2

3.74e-06272236M13380
PathwayREACTOME_XENOBIOTICS

CYP3A7 CYP3A4 CYP3A5

6.58e-0623233M5372
PathwayWP_ESTROGEN_METABOLISM_WP5276

CYP3A7 CYP3A4 CYP3A5

7.51e-0624233M46445
PathwayKEGG_LINOLEIC_ACID_METABOLISM

CYP3A7 CYP3A4 CYP3A5

1.35e-0529233M2920
PathwayWP_PREGNANE_X_RECEPTOR_PATHWAY

CYP3A7 CYP3A4 CYP3A5

1.82e-0532233M39567
PathwayBIOCARTA_ACETAMINOPHEN_PATHWAY

CYP3A4 CYP3A5

7.09e-058232MM1547
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

CYP3A7 CYP3A4 CYP3A5

7.51e-0551233M17726
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

CYP3A7 CYP3A4 CYP3A5

9.42e-0555233M14933
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

GPR83 VIPR1 ADCY3 ADCYAP1R1

1.11e-04157234M4904
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP3A7 CYP3A4 CYP3A5

1.35e-0462233M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP3A7 CYP3A4 CYP3A5

1.48e-0464233M5650
PathwayKEGG_RETINOL_METABOLISM

CYP3A7 CYP3A4 CYP3A5

1.48e-0464233M9488
PathwayWP_IRINOTECAN_PATHWAY

CYP3A4 CYP3A5

1.66e-0412232M39611
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP3A4 CYP3A5

1.66e-0412232MM15616
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

CYP3A7 CYP3A4 CYP3A5

1.93e-0470233M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

CYP3A7 CYP3A4 CYP3A5

2.10e-0472233M9257
PathwayREACTOME_ATORVASTATIN_ADME

CYP3A4 CYP3A5

2.64e-0415232MM15697
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP3A4 CYP3A5

3.83e-0418232MM14843
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

CYP3A4 CYP3A5

4.28e-0419232M27449
PathwayWP_TAMOXIFEN_METABOLISM

CYP3A4 CYP3A5

5.25e-0421232M39631
PathwayREACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS

CYP3A4 CYP3A5

5.77e-0422232MM15614
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP3A7 CYP3A4 CYP3A5

6.20e-04104233M738
PathwayREACTOME_PREDNISONE_ADME

CYP3A4 CYP3A5

6.31e-0423232MM16639
PathwayWP_GPCRS_CLASS_B_SECRETINLIKE

VIPR1 ADCYAP1R1

6.88e-0424232MM15992
PathwayWP_GPCRS_CLASS_B_SECRETINLIKE

VIPR1 ADCYAP1R1

6.88e-0424232M39643
PathwayREACTOME_XENOBIOTICS

CYP3A4 CYP3A5

7.47e-0425232MM14846
PathwayWP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES

CYP3A7 LBR CYP3A4

7.50e-04111233M48065
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

CYP3A4 CYP3A5

8.08e-0426232MM15190
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

CYP3A4 CYP3A5

1.15e-0331232M39476
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

LBR HTT

1.23e-0332232M27900
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP3A4 CYP3A5

1.30e-0333232MM1448
PathwayREACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS

VIPR1 ADCYAP1R1

1.30e-0333232M10322
PathwayREACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS

VIPR1 ADCYAP1R1

1.30e-0333232MM15066
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

GPR83 VIPR1 ADCYAP1R1

1.56e-03143233MM15055
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

GLRA3 ADCY3 GLRA2

1.59e-03144233MM14501
PathwayREACTOME_ASPIRIN_ADME

CYP3A4 CYP3A5

2.42e-0345232MM15694
PathwayWP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY

LBR ADCY3

2.52e-0346232M39828
PathwayWP_PANCREATIC_CANCER_SUBTYPES

CYP3A7 CLRN3

2.74e-0348232M48093
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

CYP3A7 CYP3A4 CYP3A5

3.15e-03183233M39588
PathwayWP_SIDS_SUSCEPTIBILITY_PATHWAYS

VIPR1 ADCYAP1R1

4.12e-0359232MM15838
PathwayREACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

VIPR1 ADCYAP1R1

4.26e-0360232MM14964
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

GLRA3 ADCY3 GLRA2

4.33e-03205233M752
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

LBR HTT

4.68e-0363232M27862
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

GLRA3 ADCY3 GLRA2

4.69e-03211233MM14502
PathwayREACTOME_SIGNALING_BY_GPCR

CCR2 GPR83 VIPR1 ADCY3 ADCYAP1R1

4.80e-03702235M746
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP3A4 CYP3A5

5.13e-0366232MM14839
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP3A7 CYP3A4 CYP3A5

5.27e-03220233M10320
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC8B1 SLC34A1 ADCY3 ABCA9 TTYH2

5.87e-03736235M27287
Pubmed

Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327332001245
Pubmed

CYP3A Polymorphism and Chronic Mercury Intoxication.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327332146629
Pubmed

The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327319801957
Pubmed

Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327323143891
Pubmed

Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327333866277
Pubmed

Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327320621111
Pubmed

Differences in CYP3A41G genotype distribution and haplotypes of CYP3A4, CYP3A5 and CYP3A7 in 3 Chinese populations.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327317582393
Pubmed

Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327320615193
Pubmed

Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327320118548
Pubmed

CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.

CYP3A7 CYP3A4 CYP3A5

4.17e-10327334688813
Pubmed

CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.

CYP3A7 CYP3A4 CYP3A5

1.67e-09427318978522
Pubmed

Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations.

CYP3A7 CYP3A4 CYP3A5

1.67e-09427334689350
Pubmed

Cytochrome P450 isoforms are differently up-regulated in aflatoxin B₁-exposed human lymphocytes and monocytes.

CYP3A7 CYP3A4 CYP3A5

4.17e-09527324168324
Pubmed

Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.

CYP3A7 CYP3A4 CYP3A5

4.17e-09527314559847
Pubmed

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

CYP3A7 CYP3A4 CYP3A5

4.17e-09527311266076
Pubmed

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

CYP3A7 CYP3A4 CYP3A5

4.17e-09527311093772
Pubmed

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.

CYP3A7 CYP3A4 CYP3A5

1.46e-08727311137287
Pubmed

Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.

CYP3A7 CYP3A4 CYP3A5

1.46e-08727319842932
Pubmed

A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.

CYP3A7 CYP3A4 CYP3A5

2.33e-08827320147896
Pubmed

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

CYP3A7 CYP3A4 CYP3A5

4.99e-081027312865317
Pubmed

CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.

CYP3A7 CYP3A4 CYP3A5

9.14e-081227315319333
Pubmed

Sequence diversity and haplotype structure at the human CYP3A cluster.

CYP3A7 CYP3A4 CYP3A5

1.19e-071327316314882
Pubmed

Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women.

CYP3A7 CYP3A4 CYP3A5

2.82e-071727319424794
Pubmed

Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.

GLRA3 VIPR1 ADCYAP1R1 GLRA2

4.60e-078127422723691
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP3A7 CYP3A4 CYP3A5

4.71e-07202739890157
Pubmed

Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.

GLRA3 GLRA2

5.80e-07227222399754
Pubmed

Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients.

CYP3A4 CYP3A5

5.80e-07227227225724
Pubmed

Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.

VIPR1 ADCYAP1R1

5.80e-07227211930171
Pubmed

Screening CYP3A single nucleotide polymorphisms in a Han Chinese population with a genotyping chip.

CYP3A4 CYP3A5

5.80e-07227216207150
Pubmed

Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype.

CYP3A4 CYP3A5

5.80e-07227215634941
Pubmed

Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.

CYP3A7 CYP3A4

5.80e-07227228986474
Pubmed

Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients: a study according to the post-transplant phase.

CYP3A4 CYP3A5

5.80e-07227226615671
Pubmed

The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation.

CYP3A4 CYP3A5

5.80e-07227228704257
Pubmed

Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo.

CYP3A4 CYP3A5

5.80e-07227215900284
Pubmed

Drugs as CYP3A probes, inducers, and inhibitors.

CYP3A4 CYP3A5

5.80e-07227218058330
Pubmed

Genetic association in CYP3A4 and CYP3A5 genes elevate the risk of prostate cancer.

CYP3A4 CYP3A5

5.80e-07227236688864
Pubmed

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.

CYP3A4 CYP3A5

5.80e-07227216684709
Pubmed

Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage.

CYP3A4 CYP3A5

5.80e-07227215900215
Pubmed

Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls.

CYP3A4 CYP3A5

5.80e-07227223491640
Pubmed

Cytochrome P450 3A-dependent metabolism of a potent and selective gamma-aminobutyric acid Aalpha2/3 receptor agonist in vitro: involvement of cytochrome P450 3A5 displaying biphasic kinetics.

CYP3A4 CYP3A5

5.80e-07227217460031
Pubmed

The rs776746 variant of CYP3A5 is associated with intravenous midazolam plasma levels and higher clearance in critically ill Mexican paediatric patients.

CYP3A4 CYP3A5

5.80e-07227233638195
Pubmed

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes.

CYP3A4 CYP3A5

5.80e-07227231309254
Pubmed

Impact of CYP3A5 and CYP3A4 gene polymorphisms on dose requirement of calcineurin inhibitors, cyclosporine and tacrolimus, in renal allograft recipients of North India.

CYP3A4 CYP3A5

5.80e-07227219343327
Pubmed

Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma.

CYP3A4 CYP3A5

5.80e-07227221380731
Pubmed

Discovery of a highly selective CYP3A4 inhibitor suitable for reaction phenotyping studies and differentiation of CYP3A4 and CYP3A5.

CYP3A4 CYP3A5

5.80e-07227222696420
Pubmed

CYP3A4/5 genotypes and age codetermine tacrolimus concentration and dosage in pediatric heart transplant recipients.

CYP3A4 CYP3A5

5.80e-07227235998509
Pubmed

CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.

CYP3A4 CYP3A5

5.80e-07227219907160
Pubmed

CYP3A gene expression in human gut epithelium.

CYP3A7 CYP3A5

5.80e-0722727894497
Pubmed

Influence of CYP3A polymorphisms on tacrolimus pharmacokinetics in kidney transplant recipients.

CYP3A4 CYP3A5

5.80e-07227232843687
Pubmed

Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.

CYP3A4 CYP3A5

5.80e-07227217605821
Pubmed

CYP3A4*1G and CYP3A5*3 genetic polymorphisms alter the antihypertensive efficacy of amlodipine in patients with hypertension following renal transplantation
.

CYP3A4 CYP3A5

5.80e-07227227841150
Pubmed

Association of genotypes of the CYP3A cluster with midazolam disposition in vivo.

CYP3A4 CYP3A5

5.80e-07227219506580
Pubmed

Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation.

CYP3A4 CYP3A5

5.80e-07227224484539
Pubmed

CYP3A4*22 and CYP3A5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.

CYP3A4 CYP3A5

5.80e-07227235471917
Pubmed

CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients.

CYP3A4 CYP3A5

5.80e-07227217495880
Pubmed

Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.

CYP3A4 CYP3A5

5.80e-07227222096084
Pubmed

Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue-engineered skin equivalents.

CYP3A4 CYP3A5

5.80e-07227229227563
Pubmed

Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide in primary human hepatocytes.

CYP3A7 CYP3A4

5.80e-07227215379787
Pubmed

Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells.

CCR2 HTT

5.80e-07227218625318
Pubmed

[Influence of CYP3A4/5 polymorphisms in the pharmacokinetics of levonorgestrel: a pilot study].

CYP3A4 CYP3A5

5.80e-07227223715232
Pubmed

Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study.

CYP3A4 CYP3A5

5.80e-07227224469018
Pubmed

Evaluating the Impacts of CYP3A4*1B and CYP3A5*3 Variations on Pharmacokinetic Behavior and Clinical Outcomes in Multiple Myeloma Patients With Autologous Stem Cell Transplant.

CYP3A4 CYP3A5

5.80e-07227236581339
Pubmed

Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.

CYP3A4 CYP3A5

5.80e-07227222645092
Pubmed

CYP3A4 and CYP3A5 genotyping by Pyrosequencing.

CYP3A4 CYP3A5

5.80e-07227215882469
Pubmed

Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors in Kidney Transplant Recipients of European Ancestry.

CYP3A4 CYP3A5

5.80e-07227233512723
Pubmed

Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.

GLRA3 GLRA2

5.80e-07227227382060
Pubmed

Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers.

CYP3A4 CYP3A5

5.80e-07227230166405
Pubmed

Biosynthesis and Identification of Metabolites of Maraviroc and Their Use in Experiments to Delineate the Relative Contributions of Cytochrome P4503A4 versus 3A5.

CYP3A4 CYP3A5

5.80e-07227229475834
Pubmed

Association between the CYP3A4 and CYP3A5 polymorphisms and cancer risk: a meta-analysis and meta-regression.

CYP3A4 CYP3A5

5.80e-07227224989928
Pubmed

Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis.

CYP3A4 CYP3A5

5.80e-07227223459029
Pubmed

CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.

CYP3A7 CYP3A5

5.80e-07227228500872
Pubmed

CYP3A4∗18B and CYP3A5∗3 polymorphisms contribute to pharmacokinetic variability of cyclosporine among healthy Chinese subjects.

CYP3A4 CYP3A5

5.80e-07227225976223
Pubmed

Association of CYP3A4/5 genotypes and expression with the survival of patients with neuroblastoma.

CYP3A4 CYP3A5

5.80e-07227225370902
Pubmed

Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.

GLRA3 GLRA2

5.80e-07227228784756
Pubmed

Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.

CYP3A7 CYP3A4

5.80e-07227225689036
Pubmed

The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients.

CYP3A4 CYP3A5

5.80e-07227233886687
Pubmed

Influence of CYP3A4*22 and CYP3A5*3 combined genotypes on tacrolimus dose requirements in Egyptian renal transplant patients.

CYP3A4 CYP3A5

5.80e-07227236379901
Pubmed

The Prognostic Role of CYP Enzyme in Kidney Transplantation: A Single Centre Experience.

CYP3A4 CYP3A5

5.80e-07227236396462
Pubmed

Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines.

CYP3A4 CYP3A5

5.80e-07227223223499
Pubmed

Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4.

CYP3A4 CYP3A5

5.80e-07227230926609
Pubmed

Influence of CYP3A5*3 polymorphism and interaction between CYP3A5*3 and CYP3A4*1G polymorphisms on post-operative fentanyl analgesia in Chinese patients undergoing gynaecological surgery.

CYP3A4 CYP3A5

5.80e-07227221513075
Pubmed

The relative contributions of CYP3A4 and CYP3A5 to the metabolism of vinorelbine.

CYP3A4 CYP3A5

5.80e-07227223780963
Pubmed

Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.

CYP3A7 CYP3A4

5.80e-07227227349315
Pubmed

Genetic diversity of CYP3A4 and CYP3A5 polymorphisms in North African populations from Morocco and Tunisia.

CYP3A4 CYP3A5

5.80e-07227225385241
Pubmed

A case-control association study between the CYP3A4 and CYP3A5 genes and schizophrenia in the Chinese Han population.

CYP3A4 CYP3A5

5.80e-07227219591893
Pubmed

CYP3A5*3 and CYP3A4*18 single nucleotide polymorphisms in a Chinese population.

CYP3A4 CYP3A5

5.80e-07227215698606
Pubmed

Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?

CYP3A4 CYP3A5

5.80e-07227220630055
Pubmed

CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer.

CYP3A4 CYP3A5

5.80e-07227214504207
Pubmed

CYP3A4 and CYP3A5 Expression is Regulated by CYP3A4*1G in CRISPR/Cas9-Edited HepG2 Cells.

CYP3A4 CYP3A5

5.80e-07227236623883
Pubmed

Decision tree-based modeling of androgen pathway genes and prostate cancer risk.

CYP3A4 CYP3A5

5.80e-07227221493872
Pubmed

Association of CYP3A4*1G and CYP3A5*3 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population.

CYP3A4 CYP3A5

5.80e-07227231064695
Pubmed

CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine.

CYP3A4 CYP3A5

5.80e-07227226654672
Pubmed

[Effect of CYP3A4*18B, CYP3A5*3 gene polymorphism on dosage and concentration of tacrolimus in renal transplant patients].

CYP3A4 CYP3A5

5.80e-07227222993851
Pubmed

Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.

CYP3A7 CYP3A4

5.80e-07227226772622
Pubmed

Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women.

CYP3A4 CYP3A5

5.80e-07227214515058
Pubmed

The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose.

CYP3A4 CYP3A5

5.80e-07227214515059
Pubmed

Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.

CYP3A7 CYP3A4

5.80e-07227226921389
Pubmed

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

CYP3A7 CYP3A4

5.80e-07227211940601
Pubmed

Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients.

CYP3A4 CYP3A5

5.80e-07227226521259
Pubmed

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue.

CYP3A7 CYP3A5

5.80e-0722728877031
InteractionCYP3A5 interactions

CYP3A7 CYP3A4 CYP3A5

4.16e-0712263int:CYP3A5
InteractionCYP3A7 interactions

CYP3A7 CYP3A5

2.39e-056262int:CYP3A7
Cytoband7q21.1

CYP3A4 CYP3A5

9.31e-0682727q21.1
CytobandEnsembl 112 genes in cytogenetic band chr7q22

CYP3A7 CYP3A4 CYP3A5

2.88e-04219273chr7q22
CytobandEnsembl 112 genes in cytogenetic band chr1q42

GPR137B LBR

8.76e-03240272chr1q42
GeneFamilyCytochrome P450 family 3

CYP3A7 CYP3A4 CYP3A5

7.53e-0882131002
GeneFamilyVasoactive intestinal peptide receptor family

VIPR1 ADCYAP1R1

3.85e-063212264
GeneFamilyGlycine receptors

GLRA3 GLRA2

1.28e-055212868
CoexpressionPRC2_EZH2_UP.V1_DN

CYP3A7 LBR GLRA2 CNGB3

4.29e-05192274M2737
CoexpressionGSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_8H_DN

GPR83 SLC8B1 CLRN3 ABCA9

4.93e-05199274M8265
CoexpressionGSE40277_EOS_AND_LEF1_TRANSDUCED_VS_CTRL_CD4_TCELL_DN

CCR2 VIPR1 LBR TTYH2

4.93e-05199274M9173
CoexpressionGSE22432_MULTIPOTENT_VS_COMMON_DC_PROGENITOR_UP

PHTF2 HEATR1 LBR CNGB3

4.93e-05199274M7821
CoexpressionGSE7460_TCONV_VS_TREG_THYMUS_UP

GPR137B VIPR1 CYP3A4 ADCYAP1R1

5.03e-05200274M5675
CoexpressionNIKOLSKY_BREAST_CANCER_7Q21_Q22_AMPLICON

CYP3A7 CYP3A4 CYP3A5

6.26e-0575273M5278
CoexpressionYAMASHITA_LIVER_CANCER_STEM_CELL_DN

CYP3A7 CYP3A4 ADCY3

6.52e-0576273M9206
CoexpressionSAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN

CYP3A7 CYP3A5

1.06e-0415272M1141
CoexpressionSAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN

CYP3A4 CYP3A5

1.92e-0420272MM1104
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

HEATR1 LBR ADCY3 HTT

4.81e-061882748f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell343B-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HEATR1 LBR ADCY3 HTT

5.22e-06192274445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

GPR137B CLRN3 CNGB3

2.82e-0598273cb0941481aef9068d7dbce0d1b6cf125f482a98d
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

GPR137B CLRN3 CNGB3

2.82e-0598273a74fb790c135bd0d0033df3aca7b789d8b25e361
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

VIPR1 HEATR1 TTYH2

6.40e-0512927364768adf23123b92280fb30eb85147cbee084ae0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLRA3 GLRA2 TTYH2

1.08e-0415427330cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLRA3 GLRA2 TTYH2

1.08e-04154273ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLRA3 GLRA2 TTYH2

1.08e-0415427342bd8f88fd075a2d4edde394785decad88a2660a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLRA3 GLRA2 TTYH2

1.08e-041542736425d9861148586466febd6eceae1b1f9b9a14c1
ToppCell(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

VIPR1 CYP3A7 CYP3A5

1.15e-0415727384f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 SLC8B1 TTYH2

1.24e-04161273a7e74bc80ac11250e353e5614b19c05793fc2e95
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR83 VIPR1 LBR

1.35e-04166273a41a20cef053c67da2d435e3e132ce28f1661c03
ToppCell343B-Lymphocytic-ILC|343B / Donor, Lineage, Cell class and subclass (all cells)

HEATR1 LBR ADCY3

1.35e-04166273a54377c703efff42d2cc1a8fdb610facc58053dd
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 CYP3A7 CYP3A5

1.43e-04169273225aec04ba762d4c55885257de03a65b63503fbb
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 CYP3A7 CYP3A5

1.43e-04169273278960f940b646a788360b1c84d641a8d169896b
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|367C / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 CYP3A7 CYP3A5

1.72e-04180273162cec1734e560c068cd61717e40e18dcf92308c
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|367C / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 CYP3A7 CYP3A5

1.72e-0418027333c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCell(7)_DC_activated|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

GPR137B P2RX2 TTYH2

1.83e-04184273b89871a3e36fde6daa68daf116f8c8d587554c0f
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADCY3 ADCYAP1R1 TTYH2

1.86e-04185273a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR137B ADCY3 TTYH2

1.86e-04185273775b72319ef6acffd2c9a74293b9c1bccea33f42
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 ABCA9 ADCYAP1R1

1.92e-041872734e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 ABCA9 ADCYAP1R1

1.92e-04187273d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 ABCA9 ADCYAP1R1

1.92e-04187273827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADCY3 ADCYAP1R1 TTYH2

1.92e-04187273a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellwk_08-11-Epithelial-PNS-intermediate_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GPR137B GPR83 TSPAN11

1.95e-041882733f3a744b2615bf72f6119f26087099110c0d21fc
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

ADCY3 ADCYAP1R1 TTYH2

1.98e-04189273d7ed96add29f219183c802895fbff519b627f635
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 ABCA9 ADCYAP1R1

2.08e-04192273ac1477433704573f95111eee6263b93668d2845e
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 ABCA9 ADCYAP1R1

2.08e-041922738937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 ABCA9 ADCYAP1R1

2.08e-04192273e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADCY3 ABCA9 ADCYAP1R1

2.11e-0419327309a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GLRA3 VIPR1 CYP3A5

2.11e-04193273aaf681f16f310168e4719464814a1fc0a2f8431a
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LBR CYP3A5 UBR4

2.14e-0419427370185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCelldistal-mesenchymal-Adventitial_Fibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

P2RX2 ABCA9 ADCYAP1R1

2.27e-04198273bfd720e2dae3b6b3dc2bf8b2096c554fd456e756
ToppCelldistal-2-mesenchymal-Adventitial_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

P2RX2 ABCA9 ADCYAP1R1

2.31e-0419927397b475f9110ef7bb29d9cf2109b7e43177830f05
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CCL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPR137B TMEM185B ADCY3

2.31e-0419927351be0e3a91d1f25454b56d55ef6342ef8e8df4e8
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CYP3A5 CLRN3 UBR4

2.34e-04200273105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

TSPAN11 ADCYAP1R1 GLRA2

2.34e-04200273de23a5d22d94935802b5b84a9e029b3f62c57028
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH|Neuronal / cells hierarchy compared to all cells using T-Statistic

TSPAN11 ADCYAP1R1 GLRA2

2.34e-042002730ff2607c58bc929e203f407ecf3605e0b21bfa90
ComputationalGenes in the cancer module 27.

GLRA3 CCR2 VIPR1 ADCYAP1R1 GLRA2

1.24e-04355165MODULE_27
ComputationalAcetylCholine receptors.

GLRA3 GLRA2

1.87e-0414162MODULE_328
ComputationalCytochrome P450.

CYP3A7 CYP3A4

1.87e-0414162MODULE_106
ComputationalGenes in the cancer module 267.

GLRA3 GLRA2

2.16e-0415162MODULE_267
ComputationalNeurotransmitter (GABA) receptor.

GLRA3 GLRA2

2.16e-0415162MODULE_215
ComputationalGenes in the cancer module 141.

SLC34A1 GLRA2

2.46e-0416162MODULE_141
ComputationalSignaling.

CYP3A7 SLC34A1 ADCYAP1R1 GLRA2

3.04e-04230164MODULE_176
ComputationalGenes in the cancer module 146.

CCR2 VIPR1 ADCYAP1R1

4.25e-04102163MODULE_146
ComputationalGenes in the cancer module 112.

CYP3A7 SLC34A1 ADCYAP1R1 GLRA2

4.84e-04260164MODULE_112
ComputationalGenes in the cancer module 135.

CYP3A7 CYP3A4

6.11e-0425162MODULE_135
ComputationalIon channels.

GLRA3 GLRA2

7.13e-0427162MODULE_214
ComputationalOxidoreductases.

CYP3A7 CYP3A4 CYP3A5

2.27e-03182163MODULE_93
ComputationalNeighborhood of IGFBP1

CYP3A7 CYP3A4

3.16e-0357162CAR_IGFBP1
ComputationalPorins / transporters.

GLRA3 ADCYAP1R1 GLRA2

3.46e-03211163MODULE_63
ComputationalIon channels.

GLRA3 GLRA2

4.73e-0370162MODULE_316
DrugAlfentanil

CYP3A7 CYP3A4 CYP3A5

2.97e-086273ctd:D015760
Drugbilobalide

GLRA3 CYP3A4 CYP3A5 GLRA2

4.21e-0830274CID000073581
Drughalothane

GLRA3 CYP3A7 LBR CYP3A4 CYP3A5 ADCY3 GLRA2

6.22e-08314277CID000003562
Drugphosphodiesterase 4 inhibitor

VIPR1 CYP3A4 CYP3A5 ADCYAP1R1

9.00e-0836274CID000656969
DrugS 840

CYP3A7 CYP3A4 CYP3A5

1.24e-079273CID000096338
Drug4-hydroxymidazolam

CYP3A7 CYP3A4 CYP3A5

1.77e-0710273CID000124449
DrugTicalopride

CYP3A7 CYP3A4 CYP3A5

2.44e-0711273CID000216236
DrugTroleandomycin

CYP3A7 CYP3A4 CYP3A5

2.44e-0711273ctd:D014217
Drugcolchicoside

GLRA3 CYP3A4 GLRA2

3.25e-0712273CID000092763
Drugpropionanilide

CYP3A7 CYP3A4 CYP3A5

5.37e-0714273CID000012107
Drug7-BFC

CYP3A7 CYP3A4 CYP3A5

5.37e-0714273CID000848780
Drugnoralfentanil

CYP3A7 CYP3A4 CYP3A5

1.00e-0617273CID000162172
Drugaflatoxin

CYP3A7 CYP3A4 CYP3A5

1.20e-0618273CID000014421
DrugAzamulinum

CYP3A7 CYP3A4 CYP3A5

1.20e-0618273CID003086060
DrugFenthion

CYP3A7 CYP3A4 CYP3A5

1.20e-0618273ctd:D005284
DrugAC1L1SX8

CYP3A7 CYP3A4 CYP3A5

1.20e-0618273CID000060278
Drug4-hydroxymidazolam

CYP3A4 CYP3A5

1.35e-062272ctd:C042940
Drugnorverapamil

CYP3A4 CYP3A5

1.35e-062272ctd:C016904
Drug5,6-dihydro-2H-pyran-2-one

CYP3A4 CYP3A5

1.35e-062272CID000520660
Drug6 beta-hydroxytestosterone

CYP3A4 CYP3A5

1.35e-062272ctd:C025591
Drugnotopterol

CYP3A4 CYP3A5

1.35e-062272CID005320227
DrugN-acetyl-S--(1,2,3,4,4-pentachlorobutadienyl)cysteine sulfoxide

CYP3A4 CYP3A5

1.35e-062272ctd:C114289
DrugCQA 206-291

CYP3A4 CYP3A5

1.35e-062272ctd:C059483
Drugfructus schizandrae, radix ginseng, radix ophiopogonis drug combination

CYP3A4 CYP3A5

1.35e-062272ctd:C009252
Drugrabeprazole

CYP3A7 CYP3A4 CYP3A5

1.42e-0619273CID000005029
DrugCID5475388

CYP3A7 CYP3A4 CYP3A5

1.67e-0620273CID005475388
Drugethyltrimethylammonium

GLRA3 P2RX2 GLRA2

1.95e-0621273CID000033993
Drugdiazepam

GLRA3 CYP3A4 CYP3A5 ADCY3 GLRA2

2.60e-06189275CID000003016
Drug5-hydroxythalidomide

CYP3A7 CYP3A4 CYP3A5

2.96e-0624273ctd:C544471
Drug1,4-naphthoquinone

CYP3A7 CYP3A4 CYP3A5

3.80e-0626273ctd:C035342
Drugerythralosamine

CYP3A4 CYP3A5

4.06e-063272CID000352196
Drug3-methoxymorphinan

CYP3A4 CYP3A5

4.06e-063272ctd:C028657
Drugdechloroethylcyclophosphamide

CYP3A4 CYP3A5

4.06e-063272ctd:C064445
Drug6 beta-hydroxydexamethasone

CYP3A4 CYP3A5

4.06e-063272CID000063050
Drugterritrem C

CYP3A4 CYP3A5

4.06e-063272CID000160306
Drug17-hydroxypregnenolone sulfate

CYP3A7 CYP3A4

4.06e-063272CID000152971
DrugN-acetyl-S-pentachloro-1,3-butadienylcysteine

CYP3A4 CYP3A5

4.06e-063272ctd:C049739
Drug1-hydroxymethylmidazolam

CYP3A4 CYP3A5

4.06e-063272ctd:C040081
Drugtienilic acid

CYP3A7 CYP3A4 CYP3A5 ADCY3

4.26e-0693274CID000038409
DrugC14845

CYP3A7 CYP3A4 CYP3A5

4.27e-0627273CID011954064
DrugBP-9,10-oxide

CYP3A7 CYP3A4 CYP3A5

4.27e-0627273CID000037456
DrugBrn 4136738

CYP3A7 CYP3A4 CYP3A5

4.27e-0627273CID000050331
Drugtariquidar

LBR CYP3A4 CYP3A5

4.27e-0627273CID000148201
Drug1,2-dichlorobenzene

GPR83 CYP3A4 CYP3A5

4.78e-0628273CID000007239
Drug9-OH-BaP-4,5-oxide

CYP3A7 CYP3A4 CYP3A5

4.78e-0628273CID000115064
DrugBN52020

GLRA3 CYP3A4 GLRA2

4.78e-0628273CID000115221
DrugBDCM

CYP3A4 CYP3A5 GLRA2

5.32e-0629273CID000006359
DrugSR-12813

CYP3A7 CYP3A4 CYP3A5

5.32e-0629273CID000446313
DrugPro 46Ae

VIPR1 SLC34A1 ADCYAP1R1

5.32e-0629273CID005485153
Drug11-H-14,15-EETA

CYP3A7 CYP3A4 CYP3A5

5.91e-0630273CID011954058
Drug19-hydroxytestosterone

CYP3A7 CYP3A4 CYP3A5

5.91e-0630273CID000150968
Drug1-methylxanthine (1-MX

GPR83 CYP3A4 CYP3A5

6.54e-0631273CID000080220
DrugBP-7,8-oxide

CYP3A7 CYP3A4 CYP3A5

7.21e-0632273CID000037455
Drugdimethadione

LBR CYP3A4 CYP3A5

7.21e-0632273CID000003081
DrugSureCN1562346

CYP3A7 CYP3A4 CYP3A5

7.92e-0633273CID011646228
Drug1-naphthol

CYP3A7 CYP3A4 CYP3A5

7.92e-0633273ctd:C029350
DrugB253

CYP3A4 CYP3A5

8.11e-064272CID000021540
Drugiso-THAZ

GLRA3 GLRA2

8.11e-064272CID003047783
Drug5-methoxyflavone

CYP3A4 CYP3A5

8.11e-064272CID000094525
Drugazacyclonol

CYP3A4 CYP3A5

8.11e-064272CID000015722
DrugPicrotoxin

GLRA3 GLRA2

8.11e-064272DB00466
DrugRo 23-7637

CYP3A4 CYP3A5

8.11e-064272CID000129491
Drugprotostrychnine

GLRA3 GLRA2

8.11e-064272CID005320746
Drug7-nitroindoline

GLRA3 GLRA2

8.11e-064272CID013566747
Drug2-(phosphonomethyl)phenylalanine

GLRA3 GLRA2

8.11e-064272CID000383689
DrugSC-49648

GLRA3 GLRA2

8.11e-064272CID000195696
DrugN-ethyl-3-toluamide

CYP3A4 CYP3A5

8.11e-064272ctd:C454678
Drugakuammiline

GLRA3 GLRA2

8.11e-064272CID005367018
Drughydroxytrimipramine

CYP3A4 CYP3A5

8.11e-064272CID000160610
DrugNSC381080

GLRA3 GLRA2

8.11e-064272CID000165497
DrugN-methyl-THIP

GLRA3 GLRA2

8.11e-064272CID000134373
DrugSC-48981

GLRA3 GLRA2

8.11e-064272CID000126573
DrugSC-50132

GLRA3 GLRA2

8.11e-064272CID000195719
DrugCQA 206-291

CYP3A4 CYP3A5

8.11e-064272CID000146782
Drugeucalyptol

CYP3A4 CYP3A5

8.11e-064272ctd:C010087
DrugSR 42641

GLRA3 GLRA2

8.11e-064272CID000129049
Drugterritrem B

CYP3A4 CYP3A5

8.11e-064272CID000114734
Drug12(13)-EpOME

CYP3A7 CYP3A4 CYP3A5

8.68e-0634273CID000001416
DrugTCEO

CYP3A7 CYP3A4 CYP3A5

8.68e-0634273CID000028167
DrugAC1L1K7W

CYP3A7 CYP3A4 CYP3A5

8.68e-0634273CID000005377
DrugAC1O5XSP

CYP3A7 CYP3A4 CYP3A5

8.68e-0634273CID006442739
Drugcisapride

CYP3A7 CYP3A4 CYP3A5 ADCY3

8.92e-06112274CID000002769
DrugAC1L1CJI

CYP3A7 CYP3A4 CYP3A5

9.49e-0635273CID000001929
Drugpantoprazole

CYP3A7 CYP3A4 CYP3A5

9.49e-0635273CID000004679
Drug15-H-11,12-EETA

CYP3A7 CYP3A4 CYP3A5

1.03e-0536273CID011954042
DrugAC1L3NGJ

CYP3A7 CYP3A4 CYP3A5

1.03e-0536273CID000092121
DrugICS-205,930

GLRA3 CYP3A4 GLRA2

1.12e-0537273CID000005595
Drugpentachlorophenol

CYP3A7 CYP3A4 CYP3A5 TTYH2

1.17e-05120274CID000000992
DrugMalathion

CYP3A7 LBR CYP3A4 CYP3A5

1.21e-05121274ctd:D008294
Drug11,14,15-THET

CYP3A7 CYP3A4 CYP3A5

1.32e-0539273CID006439531
Drugsterigmatocystin

CYP3A7 CYP3A4 CYP3A5

1.32e-0539273CID005280389
Drugazetidine-3-carboxylic acid

GLRA3 GLRA2

1.35e-055272CID000093192
DrugLindane

GLRA3 GLRA2

1.35e-055272DB00431
DrugNSC-687962

CYP3A4 CYP3A5

1.35e-055272CID000390521
DrugCao C

GLRA3 GLRA2

1.35e-055272CID000166617
Drugoxanilide

GLRA3 GLRA2

1.35e-055272CID000069288
Drugiso-THAO

GLRA3 GLRA2

1.35e-055272CID000127199
Drug6 beta-hydroxyprednisolone

CYP3A4 CYP3A5

1.35e-055272CID000152139
DrugM 0772

CYP3A4 CYP3A5

1.35e-055272CID000032485
Drug2Cmp

CYP3A4 CYP3A5

1.35e-055272CID000023392
Diseasetacrolimus measurement

CYP3A7 CYP3A4 CYP3A5

2.43e-094263EFO_0008458
Diseasemetabolonic lactone sulfate measurement

CYP3A7 CYP3A4 CYP3A5

5.83e-0719263EFO_0800659
Diseaseestrone conjugate measurement

CYP3A7 CYP3A4

4.47e-064262EFO_0007971
Diseasetauro-beta-muricholate measurement

CYP3A7 CYP3A4

7.45e-065262EFO_0800213
Diseaseglyco-beta-muricholate measurement

CYP3A7 CYP3A4

7.45e-065262EFO_0800569
Diseasedehydroisoandrosterone sulfate DHEA-S measurement

CYP3A7 CYP3A4

1.12e-056262EFO_0021119
Diseaseandrostenediol (3beta,17beta) monosulfate (1) measurement

CYP3A7 CYP3A4

1.12e-056262EFO_0800294
DiseaseX-24574 measurement

CYP3A7 CYP3A4

1.56e-057262EFO_0800897
Diseaseandrostenediol (3beta,17beta) disulfate (1) measurement

CYP3A7 CYP3A4

2.68e-059262EFO_0800278
Disease4-androsten-3alpha,17alpha-diol monosulfate (3) measurement

CYP3A7 CYP3A4

3.35e-0510262EFO_0022090
Disease5alpha-androstan-3beta,17alpha-diol disulfate measurement

CYP3A7 CYP3A4

3.35e-0510262EFO_0800289
Diseaseandrostenediol (3beta,17beta) monosulfate (2) measurement

CYP3A7 CYP3A4

4.09e-0511262EFO_0800295
DiseaseDNA repair protein RAD51 homolog 4 measurement

CYP3A7 CYP3A4

4.09e-0511262EFO_0801531
Disease5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement

CYP3A7 CYP3A4

4.90e-0512262EFO_0800291
Diseaseandrostenediol (3alpha, 17alpha) monosulfate (3) measurement

CYP3A7 CYP3A4

5.79e-0513262EFO_0800293
Disease5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement

CYP3A7 CYP3A4

5.79e-0513262EFO_0800284
DiseaseX-21470 measurement

CYP3A7 CYP3A4

6.75e-0514262EFO_0800817
Disease5alpha-androstan-3alpha,17alpha-diol monosulfate measurement

CYP3A7 CYP3A4

6.75e-0514262EFO_0800283
Diseasesulfate measurement

SLC34A1 HTT

6.75e-0514262EFO_0007864
Disease16a-hydroxy DHEA 3-sulfate measurement

CYP3A7 CYP3A4

7.78e-0515262EFO_0800301
DiseaseX-21410 measurement

CYP3A7 CYP3A4

8.89e-0516262EFO_0800813
Diseaseandro steroid monosulfate C19H28O6S (1) measurement

CYP3A7 CYP3A4

8.89e-0516262EFO_0800305
Disease5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement

CYP3A7 CYP3A4

1.13e-0418262EFO_0800288
Diseaseetiocholanolone glucuronide measurement

CYP3A7 CYP3A4

1.26e-0419262EFO_0800362
Diseaseandrosterone glucuronide measurement

CYP3A7 CYP3A4

1.40e-0420262EFO_0800317
DiseaseX-24947 measurement

CYP3A7 CYP3A4

1.71e-0422262EFO_0800910
Disease5alpha-androstan-3beta,17beta-diol disulfate measurement

CYP3A7 CYP3A4

1.71e-0422262EFO_0021115
Diseaseepiandrosterone sulfate measurement

CYP3A7 CYP3A4

2.21e-0425262EFO_0021120
Diseaseandrosterone sulfate measurement

CYP3A7 CYP3A4

3.88e-0433262EFO_0021117
DiseaseX-12063 measurement

CYP3A7 CYP3A4 CYP3A5

5.76e-04186263EFO_0021283
Diseaseend stage renal disease (biomarker_via_orthology)

CYP3A5 SLC34A1

7.88e-0447262DOID:783 (biomarker_via_orthology)
Diseaseurinary metabolite measurement

CYP3A7 CYP3A4 CYP3A5

1.28e-03245263EFO_0005116
Diseasedehydroepiandrosterone sulphate measurement

CYP3A7 CYP3A4

1.64e-0368262EFO_0007001

Protein segments in the cluster

PeptideGeneStartEntry
TWLLLAVSLVLLYLY

CYP3A5

11

P20815
LLEWLFSFLLVLFLY

ABCA9

31

Q8IUA7
LIFNIFYWVIYKILR

GLRA3

441

O75311
VYLLWFLIQVLFYLL

LBR

261

Q14739
TWLLLAVSLVLLYLY

CYP3A4

11

P08684
LYVWIFLLIFPFLLY

PCNX3

36

Q9H6A9
LEWQALLFVIFLLIY

OR11L1

21

Q8NGX0
WKYLDLATFILLYIL

GPR83

236

Q9NYM4
YFWLFIEGLYLFTLL

ADCYAP1R1

241

P41586
YRWFAVLYLLVCFLL

SLC34A1

511

Q06495
RAVQLLILLYFVWYV

P2RX2

46

Q9UBL9
LILLYFVWYVFIVQK

P2RX2

51

Q9UBL9
YFYSWLLNVLLGLLV

HTT

286

P42858
YVLWLLITAQIFSYL

ADCY3

141

O60266
VYFLFWTPYNIVILL

CCR2

251

P41597
LIFNIFYWITYKIIR

GLRA2

431

P23416
FLWILLILLFEQYVT

HEATR1

1411

Q9H583
TWLLLAVSLILLYLY

CYP3A7

11

P24462
TLYVSWLLYLFLILG

SLC8B1

101

Q6J4K2
LFVFIYVQLWLVLRY

GPR137B

56

O60478
VIFFWLLVLYLLQVA

PHTF2

136

Q8N3S3
FLCLVVLYYIVWSLL

TMEM185B

181

Q9H7F4
VLYYIVWSLLFLRSL

TMEM185B

186

Q9H7F4
SYGYSFWLILLVILL

CLRN3

176

Q8NCR9
RLYLLWLLLVTLAYN

CNGB3

216

Q9NQW8
FWLLVEGLYLYTLLA

VIPR1

231

P32241
YRWLSYLLLFILDLV

TTYH2

211

Q9BSA4
WLIIYLKYLLFVFNF

TSPAN11

11

A1L157
ACALQYYFLILWRIL

UBR4

996

Q5T4S7