Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-18 ERVK-7 ERVK-25 ERVK-9 ERVK-10	6.76e-11	37	74	7	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-18 ERVK-7 ERVK-25 ERVK-9 ERVK-10	8.26e-11	38	74	7	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.77e-10	11	74	5	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.19e-09	14	74	5	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.18e-08	21	74	5	GO:0035613
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 OTULIN JMJD7 XPNPEP3 ERVK-8 ERVK-18 USP7 ERVK-7 ERVK-25 ERVK-9 ERVK-10 PRPF8 ESPL1 ADAM8 VCPIP1	1.39e-08	654	74	15	GO:0008233
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ART4 ERVK-8 POLRMT POLR1B ERVK-7 ERVK-10 ERVK-11	9.23e-08	152	74	8	GO:0016779
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.42e-07	37	74	5	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.78e-07	38	74	5	GO:0034061
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 JMJD7 ERVK-8 ERVK-18 USP7 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ESPL1 ADAM8	5.02e-07	430	74	11	GO:0004175
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	7.42e-07	46	74	5	GO:0016893
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.11e-05	79	74	5	GO:0004521
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 POLRMT ERVK-7 ERVK-10 ERVK-11	1.13e-05	136	74	6	GO:0004540
GeneOntologyMolecularFunction	sphingolipid delta-4 desaturase activity	DEGS2 DEGS1	1.35e-05	2	74	2	GO:0042284
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-6 ART4 NTRK1 RPS6KA1 ERVK-8 POLRMT POLR1B ERVK-7 TAF1 ERVK-10 LTK STKLD1 ERVK-11	3.64e-05	938	74	13	GO:0016772
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.50e-04	136	74	5	GO:0004519
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	ERVK-6 ERVK-8 POLRMT POLR1B ERVK-7 VARS2 ERVK-10 ERVK-11	1.53e-04	417	74	8	GO:0140098
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ERVK-8 POLRMT ERVK-7 ERVK-10 ERVK-11	2.16e-04	231	74	6	GO:0004518
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 MGAT5 XPNPEP3 ERVK-8 POLR1B SLC39A4 ERVK-7 ERVK-9 ERVK-10 ERVK-11 RNF139 ADAM8 F5	3.88e-04	1189	74	13	GO:0046914
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	TAF1C TAF1	4.80e-04	9	74	2	GO:0001181
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	DEGS2 DEGS1	1.03e-03	13	74	2	GO:0016717
GeneOntologyMolecularFunction	core promoter sequence-specific DNA binding	CEBPB TAF1C TAF1	1.12e-03	55	74	3	GO:0001046
GeneOntologyMolecularFunction	deubiquitinase activity	OTULIN USP7 PRPF8 VCPIP1	1.17e-03	124	74	4	GO:0101005
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 ERVK-8 POLR1B SLC39A4 ERVK-7 ERVK-9 ERVK-10 ERVK-11 RNF139 ADAM8	1.60e-03	891	74	10	GO:0008270
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	OTULIN USP7 PRPF8 VCPIP1	1.68e-03	137	74	4	GO:0019783
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH8 DNAH1	1.99e-03	18	74	2	GO:0008569
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	PIEZO2 PIEZO1	1.99e-03	18	74	2	GO:0008381
GeneOntologyMolecularFunction	general transcription initiation factor activity	TBPL2 TAF1C TAF1	2.06e-03	68	74	3	GO:0140223
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 ERVK-8 POLRMT POLR1B ERVK-7 VARS2 ERVK-10 ERVK-11	2.62e-03	645	74	8	GO:0140640
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.89e-03	262	74	5	GO:0140097
GeneOntologyMolecularFunction	RNA polymerase II core promoter sequence-specific DNA binding	CEBPB TAF1	3.85e-03	25	74	2	GO:0000979
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH8 DNAH1	4.81e-03	28	74	2	GO:0051959
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	5.67e-10	13	72	5	GO:0015074
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	6.86e-07	48	72	5	GO:0000731
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.06e-05	83	72	5	GO:0006278
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 ERVK-8 POLRMT ERVK-7 ERVK-10 ERVK-11	3.70e-05	178	72	6	GO:0006261
GeneOntologyBiologicalProcess	regulation of eosinophil migration	CD300A ADAM8	1.79e-04	6	72	2	GO:2000416
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-9 ADAM8	2.23e-04	85	72	4	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-9 ADAM8	2.23e-04	85	72	4	GO:0000768
HumanPheno	Coiled sperm flagella	SPEF2 CFAP74 DNAH8 DNAH1	2.36e-05	32	28	4	HP:0032560
Domain	DES1/DES2	DEGS2 DEGS1	1.12e-05	2	63	2	IPR011388
Domain	Lipid_DES	DEGS2 DEGS1	1.12e-05	2	63	2	PF08557
Domain	Sphingolipid_d4-desaturase_N	DEGS2 DEGS1	1.12e-05	2	63	2	IPR013866
Domain	PIEZO	PIEZO2 PIEZO1	1.12e-05	2	63	2	PF15917
Domain	Piezo_RRas-bd_dom	PIEZO2 PIEZO1	1.12e-05	2	63	2	IPR031334
Domain	Piezo	PIEZO2 PIEZO1	1.12e-05	2	63	2	IPR027272
Domain	Piezo_RRas_bdg	PIEZO2 PIEZO1	1.12e-05	2	63	2	PF12166
Domain	Piezo_dom	PIEZO2 PIEZO1	1.12e-05	2	63	2	IPR031805
Domain	Lipid_DES	DEGS2 DEGS1	1.12e-05	2	63	2	SM01269
Domain	FA_desaturase_dom	DEGS2 DEGS1	3.09e-04	8	63	2	IPR005804
Domain	FA_desaturase	DEGS2 DEGS1	3.09e-04	8	63	2	PF00487
Domain	Tyr_kinase_rcpt_2_CS	NTRK1 LTK	6.04e-04	11	63	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	NTRK1 LTK	7.23e-04	12	63	2	PS00239
Domain	Dynein_heavy_chain_D4_dom	DNAH8 DNAH1	9.93e-04	14	63	2	IPR024317
Domain	Dynein_HC_stalk	DNAH8 DNAH1	9.93e-04	14	63	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH8 DNAH1	9.93e-04	14	63	2	IPR013602
Domain	NPIP	NPIPB8 NPIPB6	9.93e-04	14	63	2	IPR009443
Domain	DHC_N2	DNAH8 DNAH1	9.93e-04	14	63	2	PF08393
Domain	MT	DNAH8 DNAH1	9.93e-04	14	63	2	PF12777
Domain	AAA_8	DNAH8 DNAH1	9.93e-04	14	63	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH8 DNAH1	9.93e-04	14	63	2	IPR011704
Domain	AAA_5	DNAH8 DNAH1	9.93e-04	14	63	2	PF07728
Domain	DHC_fam	DNAH8 DNAH1	1.14e-03	15	63	2	IPR026983
Domain	Dynein_heavy_dom	DNAH8 DNAH1	1.14e-03	15	63	2	IPR004273
Domain	Dynein_heavy	DNAH8 DNAH1	1.14e-03	15	63	2	PF03028
Domain	Cupredoxin	PRPF8 F5	2.48e-03	22	63	2	IPR008972
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-18 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ERVK-11	4.22e-11	94	78	8	21542922
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-18 ERVK-25 ERVK-9 ERVK-10 ERVK-11	4.17e-10	18	78	5	18664271
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9 ERVK-11	1.09e-08	3	78	3	9971820
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10	4.33e-08	4	78	3	10469592
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-18 ERVK-7	1.08e-07	5	78	3	12629516
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-9	2.35e-06	12	78	3	14557543
Pubmed	[Feeling the pressure? Identification of two proteins activated by mechanical forces].	PIEZO2 PIEZO1	4.97e-06	2	78	2	21299953
Pubmed	Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.	PIEZO2 PIEZO1	4.97e-06	2	78	2	38395992
Pubmed	Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.	PIEZO2 PIEZO1	4.97e-06	2	78	2	37820892
Pubmed	Mechanisms of mechanotransduction and physiological roles of PIEZO channels.	PIEZO2 PIEZO1	4.97e-06	2	78	2	39251883
Pubmed	Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.	PIEZO2 PIEZO1	4.97e-06	2	78	2	37975162
Pubmed	Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.	PIEZO2 PIEZO1	4.97e-06	2	78	2	28636944
Pubmed	Piezo channels: from structure to function.	PIEZO2 PIEZO1	4.97e-06	2	78	2	25037583
Pubmed	Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?	PIEZO2 PIEZO1	4.97e-06	2	78	2	30324494
Pubmed	Mechanosensitive channels: in touch with Piezo.	PIEZO2 PIEZO1	4.97e-06	2	78	2	21056836
Pubmed	Identification and characterization of a sphingolipid delta 4-desaturase family.	DEGS2 DEGS1	4.97e-06	2	78	2	11937514
Pubmed	Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.	PIEZO2 PIEZO1	4.97e-06	2	78	2	30745454
Pubmed	The role of PIEZO ion channels in the musculoskeletal system.	PIEZO2 PIEZO1	4.97e-06	2	78	2	36717101
Pubmed	Astrocytes in the optic nerve head express putative mechanosensitive channels.	PIEZO2 PIEZO1	4.97e-06	2	78	2	26236150
Pubmed	Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.	PIEZO2 PIEZO1	4.97e-06	2	78	2	27743844
Pubmed	Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.	PIEZO2 PIEZO1	4.97e-06	2	78	2	38928429
Pubmed	Dihydroceramide-based response to hypoxia.	DEGS2 DEGS1	4.97e-06	2	78	2	21914808
Pubmed	A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.	PIEZO2 PIEZO1	4.97e-06	2	78	2	30628892
Pubmed	Piezo1 ion channel pore properties are dictated by C-terminal region.	PIEZO2 PIEZO1	4.97e-06	2	78	2	26008989
Pubmed	Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.	PIEZO2 PIEZO1	4.97e-06	2	78	2	20813920
Pubmed	A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.	PIEZO2 PIEZO1	4.97e-06	2	78	2	32142647
Pubmed	Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.	PIEZO2 PIEZO1	4.97e-06	2	78	2	34464353
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	4.97e-06	2	78	2	11672541
Pubmed	PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.	TAF1C POLR1B	1.49e-05	3	78	2	16055704
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18	1.49e-05	3	78	2	10516026
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO2 PIEZO1	1.49e-05	3	78	2	30726728
Pubmed	Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.	PIEZO2 PIEZO1	1.49e-05	3	78	2	38124148
Pubmed	Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.	PIEZO2 PIEZO1	1.49e-05	3	78	2	29521261
Pubmed	PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.	PIEZO2 PIEZO1	1.49e-05	3	78	2	30361375
Pubmed	Piezo1, a mechanically activated ion channel, is required for vascular development in mice.	PIEZO2 PIEZO1	1.49e-05	3	78	2	24958852
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO2 PIEZO1	1.49e-05	3	78	2	37321223
Pubmed	Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.	PIEZO2 PIEZO1	1.49e-05	3	78	2	35650194
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	PIEZO2 PIEZO1	2.97e-05	4	78	2	27893727
Pubmed	The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3.	OTULIN IRF3	2.97e-05	4	78	2	34545182
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	PIEZO2 PIEZO1	2.97e-05	4	78	2	36574677
Pubmed	The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF.	TAF1C TAF1	2.97e-05	4	78	2	12498690
Pubmed	Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems.	TAF1 F5	2.97e-05	4	78	2	16155788
Pubmed	Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.	PIEZO2 PIEZO1	2.97e-05	4	78	2	36563677
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10	2.97e-05	4	78	2	7983737
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	PIEZO2 PIEZO1	4.94e-05	5	78	2	34852225
Pubmed	The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors.	OTULIN USP7	4.94e-05	5	78	2	26235645
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	4.94e-05	5	78	2	11401426
Pubmed	C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.	CEBPB RPS6KA1	4.94e-05	5	78	2	11684016
Pubmed	Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.	CEBPB RPS6KA1	4.94e-05	5	78	2	10635333
Pubmed	Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex.	TAF1C TAF1	4.94e-05	5	78	2	24928901
Pubmed	Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.	PIEZO2 PIEZO1	4.94e-05	5	78	2	36323321
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-9	7.40e-05	6	78	2	15063128
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH8 DNAH1	1.04e-04	7	78	2	9256245
Pubmed	Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.	PIEZO2 PIEZO1	1.04e-04	7	78	2	38733989
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	PHF3 SPEF2 CAPRIN2 DOP1A VCPIP1	1.08e-04	208	78	5	33230847
Pubmed	Piezo1 and Piezo2 collectively regulate jawbone development.	PIEZO2 PIEZO1	1.38e-04	8	78	2	38619396
Pubmed	TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.	PIEZO2 PIEZO1	1.38e-04	8	78	2	34112781
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	PIEZO2 PIEZO1	1.38e-04	8	78	2	38228630
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	PIEZO2 PIEZO1	1.38e-04	8	78	2	27161260
Pubmed	hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.	TAF1C POLR1B	1.38e-04	8	78	2	11250903
Pubmed	The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.	NTRK1 LTK	1.77e-04	9	78	2	12237455
Pubmed	Confirmation of quantitative trait loci for cocaine-induced activation in the AcB/BcA series of recombinant congenic strains.	GRIK4 CHRND	1.77e-04	9	78	2	12777963
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	NTRK1 MUC16 GRIK4 LTK DNAH8 DOP1A	3.69e-04	420	78	6	28065597
Pubmed	USP51 promotes deubiquitination and stabilization of ZEB1.	USP7 VCPIP1	3.81e-04	13	78	2	29119051
Pubmed	Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.	TAF1C POLR1B	3.81e-04	13	78	2	15226435
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH8 DNAH1	4.44e-04	14	78	2	9373155
Pubmed	Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.	USP7 VCPIP1	5.12e-04	15	78	2	29295817
Pubmed	Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.	USP7 PRPF8	5.84e-04	16	78	2	28803780
Pubmed	A vagal reflex evoked by airway closure.	PIEZO2 PIEZO1	5.84e-04	16	78	2	38448588
Pubmed	The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function.	FRZB DEGS1	5.84e-04	16	78	2	9817915
Pubmed	Rrn3 becomes inactivated in the process of ribosomal DNA transcription.	TAF1C POLR1B	8.28e-04	19	78	2	12646563
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTULIN VCPIP1	8.28e-04	19	78	2	23827681
Pubmed	Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development.	NTRK1 FRZB	8.28e-04	19	78	2	22491945
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	PHF3 ASS1 USP7 TAF1 PRPF8	9.18e-04	332	78	5	32786267
Pubmed	A molecular genetic linkage map of mouse chromosome 2.	ASS1 LTK	9.19e-04	20	78	2	1970329
Pubmed	Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain.	PIEZO2 NTRK1	9.19e-04	20	78	2	36334588
Pubmed	Regulation of the endosomal SNX27-retromer by OTULIN.	OTULIN STEAP3	1.01e-03	21	78	2	31541095
Pubmed	Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.	TAF1C POLR1B	1.11e-03	22	78	2	9582279
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	TAF1C POLR1B	1.22e-03	23	78	2	12393749
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PHF3 LARP1 STEAP3 TOMM34 POLR1B ESPL1 VCPIP1	1.30e-03	733	78	7	34672954
Pubmed	Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.	PIEZO2 PIEZO1	1.33e-03	24	78	2	32186512
Pubmed	A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.	NTRK1 FRZB	1.33e-03	24	78	2	9096311
Pubmed	Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.	NTRK1 CHRND	1.33e-03	24	78	2	26115514
Pubmed	Patterning the dorsal telencephalon: a role for sonic hedgehog?	FRZB GRIK4	1.44e-03	25	78	2	17959802
Pubmed	Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.	SLC17A3 STEAP3 SLC39A4	1.54e-03	101	78	3	20587610
Pubmed	Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.	NTRK1 FRZB	1.56e-03	26	78	2	23827310
Pubmed	The transcription factor c-Maf controls touch receptor development and function.	PIEZO2 NTRK1	1.68e-03	27	78	2	22345400
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	DEGS2 DEGS1	1.68e-03	27	78	2	25269881
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TNRC18 CAPRIN2 VCPIP1	1.82e-03	107	78	3	11347906
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PHF3 PLEKHG3 ASS1 POLRMT USP7 LARP1 POLR1B PRPF8 F5	1.99e-03	1257	78	9	36526897
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	CEBPB PHF3 USP7 LARP1 TAF1 PRPF8	2.00e-03	583	78	6	29844126
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	POLRMT POLR1B ESPL1 VCPIP1	2.18e-03	242	78	4	34011540
Pubmed	ZFP750 affects the cutaneous barrier through regulating lipid metabolism.	DEGS2 DEGS1	2.21e-03	31	78	2	37115925
GeneFamily	Fatty acid desaturases	DEGS2 DEGS1	1.61e-04	8	44	2	553
GeneFamily	Dyneins, axonemal	DNAH8 DNAH1	7.69e-04	17	44	2	536
GeneFamily	OTU domain containing	OTULIN VCPIP1	7.69e-04	17	44	2	669
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	NTRK1 LTK	4.26e-03	40	44	2	321
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	YIPF2 ASS1 MUC16 ESPL1 CASC2	8.29e-06	175	70	5	3b5346fba617292de71963b6175e85a4f182fe30
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell\|World / Lineage, cell class and subclass	CD300A RPS6KA1 TNFRSF18 GRIK4 ADAM8	9.76e-06	181	70	5	0d096d7d557fd2e71b35e41816e11d7e83cd9210
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CEBPB PLEKHG3 CD300A F5	5.92e-05	134	70	4	932b7dd5781b730dcd2ffe43f6e142e3f8630f67
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBPL2 DEGS2 DNAH8 CHRND	7.83e-05	144	70	4	e9d62f202f0fa8747961036ef0eafed91fe8a42f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MGAT5 SLC39A4 TNFRSF18 DOP1A	1.04e-04	155	70	4	93f21b09f6f7755991d67886361b1c42a50fbbfc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRZB TNFRSF18 GRIK4 LTK	1.12e-04	158	70	4	0c9bb7f8d080a052ca71701544a076c6c2ea67cd
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRZB TNFRSF18 GRIK4 LTK	1.12e-04	158	70	4	cebb58878b6945074bc1c7d5848d842da5dcbae1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRZB TNFRSF18 GRIK4 LTK	1.12e-04	158	70	4	2cfa6dd36c8ae534cf1dd49366d4b4433388c1e0
ToppCell	IIF-Lymphocyte-T_NK-ILC\|IIF / Disease, Lineage and Cell Type	POLR1B TNFRSF18 FER1L5 DNAH1	1.15e-04	159	70	4	55e4f21548f480ca414c00cbff5ec3b13bafd271
ToppCell	facs-Lung-EPCAM-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPB CD300A ADAM8 F5	1.18e-04	160	70	4	b73f07a0088936fbc3656a05710a67f38b4ae551
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPB CD300A ADAM8 F5	1.18e-04	160	70	4	b88876a58fea2066468e74dcc439c8561130a910
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG3 CD300A ADAM8 F5	1.21e-04	161	70	4	e227f7b711475624cf80e77f235b1783d88d57b4
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|367C / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG3 TAF1C IRF3 PIGM	1.21e-04	161	70	4	f470b662566131dfe69a2fd01186ac8491196396
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG3 CD300A ADAM8 F5	1.21e-04	161	70	4	8280a029026c272cae9649b27575831b0dd4e242
ToppCell	facs-MAT-Fat-24m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPB CD300A ADAM8 F5	1.21e-04	161	70	4	65888250b8c1da6a8f9b5376e086a3769a1cbbd8
ToppCell	normal-na-Lymphocytic_NK-NK_bright-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CD300A TNFRSF18 GRIK4 CHRND	1.29e-04	164	70	4	b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CEBPB CD300A ADAM8 F5	1.36e-04	166	70	4	3195035445d35d820f5e00dd03b029730478b024
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CEBPB CD300A ADAM8 F5	1.36e-04	166	70	4	6b6ecd70264b6bfbd8a3a378c965702829e2ecf1
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPEF2 CFAP74 CASC2 DNAH1	1.45e-04	169	70	4	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPEF2 MUC16 CFAP74 CASC2	1.45e-04	169	70	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ART4 DEFB109B CHRND	1.47e-04	65	70	3	c736a773a1b9cb16b51849a3bf0ccd9aeec7b342
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ART4 DEFB109B CHRND	1.47e-04	65	70	3	8f7eac868f1605830cc97d9d1676f3ebff47d49b
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ART4 DEFB109B CHRND	1.47e-04	65	70	3	350f33bcc5924d7e3c3318391d33a984763fe206
ToppCell	droplet-Spleen-nan-21m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 CEBPB CD300A GRIK4	1.49e-04	170	70	4	03cb4e508356f85372a588c8d1c6babf2a012683
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Basophil\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNRC18 PLEKHG3 ADAM8 F5	1.59e-04	173	70	4	2cba41c3d9d3076f703115d19729073a3ac3feb6
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNRC18 PLEKHG3 ADAM8 F5	1.59e-04	173	70	4	11d69a4ab4a87b8820cd3bd204de8c4124450a90
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAT5 SPEF2 TNFRSF18 CNTN1	1.62e-04	174	70	4	a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAT5 SPEF2 TNFRSF18 CNTN1	1.62e-04	174	70	4	7f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPB ADAM8 F5 DEGS1	1.73e-04	177	70	4	065bebd22031f143e90a407f952b444a3f8818c7
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TNRC18 NTRK1 POLR1B VARS2	1.73e-04	177	70	4	36b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell	facs-Marrow-Granulocytes-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPB ADAM8 F5 DEGS1	1.73e-04	177	70	4	eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCell	wk_20-22-Hematologic_Lymphocytic-NK-Activated_NK\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CD300A NTRK1 TNFRSF18 ADAM8	1.77e-04	178	70	4	5b19dbf9dc8e41e6a16a2abbb798d49ee8d8653f
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEF2 CAPRIN2 CFAP74 DNAH1	1.77e-04	178	70	4	b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEF2 CAPRIN2 CFAP74 DNAH1	1.77e-04	178	70	4	579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	CFAP74 F5 DEGS1 DOP1A	1.85e-04	180	70	4	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 CNKSR2 CNTN1 DNAH1	2.01e-04	184	70	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	(1)_T_cells-(1)_T_regulatory\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	FAM78B TNFRSF18 F5 DNAH8	2.01e-04	184	70	4	3cbf81757653652441843d85cb7ec1dcf25ca1b0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 CNKSR2 CNTN1 DNAH1	2.01e-04	184	70	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 CNKSR2 CNTN1 DNAH1	2.01e-04	184	70	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	SPEF2 MUC16 CFAP74 CASC2	2.05e-04	185	70	4	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	COVID-19_Moderate-NK_activated\|World / disease group, cell group and cell class	PLEKHG3 CD300A GRIK4 ADAM8	2.10e-04	186	70	4	ff8f32f69516bf785224fa12f8139a95359b0279
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PLEKHG3 TNFRSF18 GRIK4 ADAM8	2.10e-04	186	70	4	c984e5729958237b101df96d1c89a236faacded6
ToppCell	droplet-Heart-HEART-1m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPRIN2 SLC39A4 GRIK4 F5	2.10e-04	186	70	4	fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ART4 FRZB DNAH8 CNTN1	2.23e-04	189	70	4	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CEBPB C20orf204 TNFRSF18 RNF139	2.23e-04	189	70	4	284f39dfacec76004daae9dd5317fb7b1f04fa99
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ART4 FRZB DNAH8 CNTN1	2.23e-04	189	70	4	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	COVID-19_Moderate-NK_activated\|COVID-19_Moderate / disease group, cell group and cell class	PLEKHG3 CD300A GRIK4 ADAM8	2.23e-04	189	70	4	8f9f1e71857bed6d59c4b087b6a6970f30fd86be
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIEZO2 CNKSR2 GRIK4 CNTN1	2.23e-04	189	70	4	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-5\|TCGA-Kidney / Sample_Type by Project: Shred V9	ART4 MROH2B CNTN1	2.25e-04	75	70	3	c1ab2eb49eebfdb10dc32c935804e8771260ca6c
ToppCell	CV-Healthy-0\|CV / Virus stimulation, Condition and Cluster	CD300A RPS6KA1 TNFRSF18 ADAM8	2.27e-04	190	70	4	559e6c18b938aa41856358a2087f33b0a1b7b245
ToppCell	control-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CEBPB TECPR2 PLEKHG3 ADAM8	2.32e-04	191	70	4	db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CEBPB CD300A TMED5 ADAM8	2.32e-04	191	70	4	cf217d00ba2b0402a8e72fcd64bdb36d5539dde0
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPEF2 MUC16 CFAP74 CASC2	2.32e-04	191	70	4	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPEF2 MUC16 CFAP74 CASC2	2.32e-04	191	70	4	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CD300A TNFRSF18 GRIK4 ADAM8	2.32e-04	191	70	4	6345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPEF2 MUC16 CFAP74 CASC2	2.32e-04	191	70	4	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ASS1 MUC16 DEGS2 CASC2	2.36e-04	192	70	4	8899d81306770adda893b5e146df1253971754c5
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	PIEZO1 CAPRIN2 LARP1 ESPL1	2.36e-04	192	70	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ASS1 MUC16 DEGS2 CASC2	2.36e-04	192	70	4	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	Ciliated-cil-3\|World / Class top	SPEF2 CFAP74 ADAM8 DNAH1	2.36e-04	192	70	4	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	SPEF2 MUC16 CFAP74 CASC2	2.36e-04	192	70	4	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC17A3 SLC6A16 MROH2B DNAH8	2.41e-04	193	70	4	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG3 CD300A TNFRSF18 ADAM8	2.41e-04	193	70	4	54604c2c5dce2ff6f3ec7ca82b595b09b8cdafe8
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPEF2 STEAP3 CFAP74 CASC2	2.41e-04	193	70	4	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG3 CD300A RPS6KA1 ADAM8	2.41e-04	193	70	4	b53ffef20f918b7d1e9d3924562691d13245e2dd
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIEZO2 CNKSR2 GRIK4 CNTN1	2.46e-04	194	70	4	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	CD8+_Memory_T_cell-CV-6\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	CD300A RPS6KA1 TNFRSF18 ADAM8	2.46e-04	194	70	4	35a347c3824757b9de8b7f49db46e73e7fb63a4f
ToppCell	(4)_Endothelial_cells-(4)_Lymph_vessel\|(4)_Endothelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	PIEZO2 ART4 PLEKHG3 DEGS2	2.46e-04	194	70	4	9735b86d3b2480a0b34d8aab8e7bd609d83c2454
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PIEZO2 CEBPB GRIK4 CNTN1	2.46e-04	194	70	4	a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell	lymphoid-NK_cell\|World / Lineage, cell class and subclass	PLEKHG3 CD300A TNFRSF18 ADAM8	2.46e-04	194	70	4	4bf5a140be8691e4ec99d7ee15588fd48acd6fb5
ToppCell	T_cells-CD56_dim_CD16+_NK_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PLEKHG3 CD300A GRIK4 ADAM8	2.46e-04	194	70	4	335c6c2f3f319d4f19eace62f8826a0f40c130f6
ToppCell	COVID-19-Epithelial-Ciliated_cells\|COVID-19 / Condition, Lineage and Cell class	SPEF2 MUC16 CFAP74 DEGS2	2.46e-04	194	70	4	43be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_NK-NK_CD16\|lymph-node_spleen / Manually curated celltypes from each tissue	PLEKHG3 CD300A TNFRSF18 ADAM8	2.51e-04	195	70	4	e756733cf48768bf40058d6cf9039e52f7563133
ToppCell	T/NK_cells-CD56dim_NK_cell\|World / Lineage and Cell class	PLEKHG3 CD300A TNFRSF18 ADAM8	2.51e-04	195	70	4	6124e87cb9061bf8918377fb4a79084079ddfc16
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPIPB6 DNAH8 CHRND DOP1A	2.51e-04	195	70	4	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	mLN-B_cell-B_cell_IgG_Plasma\|mLN / Region, Cell class and subclass	YIPF2 FRZB ASS1 TNFRSF18	2.56e-04	196	70	4	03b79f237e4f7ebab46b277d05377569c6342cf7
ToppCell	mLN-(2)_B_cell-(21)_B_cell_IgG_Plasma\|mLN / shred on region, Cell_type, and subtype	YIPF2 FRZB ASS1 TNFRSF18	2.56e-04	196	70	4	e8b12b046d42a58e6f4d9419ab05a5c55e764f34
ToppCell	T_cells-CD56_dim_CD16+_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PLEKHG3 CD300A GRIK4 ADAM8	2.56e-04	196	70	4	07b557b8530c19ca5b31ad2eac00c36ef1939266
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-NK_CD16\|bone_marrow / Manually curated celltypes from each tissue	PLEKHG3 CD300A TNFRSF18 ADAM8	2.56e-04	196	70	4	a3b077e82b1550eb328c84b567b60179001f9a77
ToppCell	10x5'-bone_marrow-Lymphocytic_NK\|bone_marrow / Manually curated celltypes from each tissue	PLEKHG3 CD300A TNFRSF18 ADAM8	2.56e-04	196	70	4	1868ad537b7f04cdad0a0c8282aadbc4f257a722
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CD300A TNFRSF18 DEGS2 ADAM8	2.61e-04	197	70	4	76304df40f87224f8e415677e3ee8fb183fe0c03
ToppCell	mLN-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	YIPF2 FRZB ASS1 TNFRSF18	2.61e-04	197	70	4	bd1d01d6c49f68f5c85d84df96c90dd04b9de09b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PIEZO2 CNKSR2 GRIK4 CNTN1	2.61e-04	197	70	4	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PIEZO2 CNKSR2 GRIK4 CNTN1	2.61e-04	197	70	4	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid-Microglia\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	CEBPB CD300A RPS6KA1 PIEZO1	2.66e-04	198	70	4	901cd39cb84f1907f2f5d27221979c854bd3b40e
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	CEBPB CD300A RPS6KA1 PIEZO1	2.66e-04	198	70	4	cc292aa8518d5ef8940e2327f2f07d584a996d90
ToppCell	mild-Lymphocytic-NK_cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PLEKHG3 CD300A GRIK4 ADAM8	2.66e-04	198	70	4	1d20fc9948965de52a98f758035edfdd12cafc5f
ToppCell	mLN-T_cell-Th1\|mLN / Region, Cell class and subclass	CEBPB CFAP74 LTK CHRND	2.66e-04	198	70	4	7627b7c3a248da2bd5e1e6f7c226e5fd0bc92113
ToppCell	mLN-(1)_T_cell-(12)_Th1\|mLN / shred on region, Cell_type, and subtype	CEBPB CFAP74 LTK CHRND	2.66e-04	198	70	4	1fe8257233232b264b9ca630c2d92c509a195353
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-NK\|Multiple_Sclerosis / Disease, Lineage and Cell Type	PLEKHG3 CD300A TNFRSF18 ADAM8	2.66e-04	198	70	4	d413020012977eb8da0a5641dd16d0b0a60bec38
ToppCell	(0)_NK_cells\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PLEKHG3 CD300A TNFRSF18 ADAM8	2.66e-04	198	70	4	c91c3ccba118dffb12c0bf8036f51fc76f0e305d
ToppCell	severe-NK\|severe / disease stage, cell group and cell class	PLEKHG3 CD300A TNFRSF18 ADAM8	2.66e-04	198	70	4	cb505077dc5bdf3fdd513bb9032e32bb9644c004
ToppCell	mLN-(0)_NK_cell-(00)_NK\|mLN / shred on region, Cell_type, and subtype	OTULIN CD300A GRIK4 ADAM8	2.71e-04	199	70	4	59d8e4f57580c7273308c32e5308fc1d704b1f6d
ToppCell	mLN-NK_cell-NK\|mLN / Region, Cell class and subclass	OTULIN CD300A GRIK4 ADAM8	2.71e-04	199	70	4	cc9836b8d18edabe8849a3e948b84d954ef68c48
ToppCell	COVID-19_Moderate-NK\|COVID-19_Moderate / disease group, cell group and cell class	PLEKHG3 CD300A TNFRSF18 GRIK4	2.71e-04	199	70	4	e0e83ba511957be9ad3413460dcb6b7d7b65dd18
ToppCell	mLN-NK_cell\|mLN / Region, Cell class and subclass	OTULIN CD300A GRIK4 ADAM8	2.71e-04	199	70	4	dcc1d9a3f6f0e64f111d18386bfe5b154e9d5bbe
ToppCell	mLN-(0)_NK_cell\|mLN / shred on region, Cell_type, and subtype	OTULIN CD300A GRIK4 ADAM8	2.71e-04	199	70	4	05f5ae4c049f242131a7f59bcce4b18ed52f11be
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	CEBPB CD300A RPS6KA1 PIEZO1	2.76e-04	200	70	4	25f4c051c2e869481f33c22ad54de97efac444ad
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-NK\|Multiple_Sclerosis / Disease, condition lineage and cell class	PLEKHG3 CD300A TNFRSF18 ADAM8	2.76e-04	200	70	4	d7a611d88107d84b5995b353e8cf95c6a7eb79de
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-BMP_responsible_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	CEBPB CD300A RPS6KA1 PIEZO1	2.76e-04	200	70	4	26251ed8c7fa7e87973d6f59bd398c88ad025395
Computational	Neighborhood of ORC1L	TOMM34 TAF1 PRPF8 CNTN1	7.01e-05	69	35	4	MORF_ORC1L
Disease	caudate volume change measurement	MGAT5 CNKSR2	4.68e-04	14	68	2	EFO_0021491
Disease	Deep Vein Thrombosis	F5 PIGM	1.07e-03	21	68	2	C0149871
Disease	Venous Thrombosis	F5 PIGM	1.07e-03	21	68	2	C0042487
Disease	inflammatory biomarker measurement	PIEZO2 F5	1.64e-03	26	68	2	EFO_0004872
Disease	D dimer measurement	F5 CNTN1	2.18e-03	30	68	2	EFO_0004507

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRLPPDMVWLPEIVL	CHRND	101	Q07001
MEWAQPRLPKPALPL	NKAPP1	61	Q8N9T2
MVPPKPALWALLLAL	C20orf204	1	A0A1B0GTL2
DAQVLMWRPKRGPPL	FAM78B	241	Q5VT40
SRPLWMASIIPPDMI	DOP1A	1706	Q5JWR5
AMMLPAIAPSRPWAL	ADAM8	11	P78325
APQIKVIAPWRMPEF	ASS1	136	P00966
DVSWMSPPLLEKTRP	MUC16	7956	Q8WXI7
KWVPLQIDMKPEVPR	LARP1	251	Q6PKG0
PLPIKAMLRSLPIWS	SLC17A3	206	O00476
RTMLPIRWMPPESIL	NTRK1	686	P04629
MWPPLSALQVKLAEP	MGAT5	631	Q09328
AMEKVPWIPLDPLAP	JMJD7	231	P0C870
DRALLPVKWMPPEAF	LTK	681	P29376
PLARNMPPIAGKILW	DNAH8	506	Q96JB1
IPPSARKPLCNWVRM	NPIPB8	221	E9PQR5
LPSPAMIPKDWPLII	HERVK_113	106	P63132
LPSPAMIPKDWPLII	ERVK-7	106	P63135
LPSPAMIPKDWPLII	ERVK-6	106	Q9BXR3
LPSPAMIPKDWPLII	ERVK-18	106	Q9QC07
PPWLQDPELMLLPEK	OTULIN	146	Q96BN8
MPFIECWLRKLPPLL	DNAH1	2016	Q9P2D7
KLPWESMPSLQALPV	ESPL1	1901	Q14674
PCVITMNPALPWKLE	CASC2	76	Q6XLA1
MQRLVAWDPACLPLP	CEBPB	1	P17676
PDIRWRKVLEPMPST	CNTN1	271	Q12860
PEIKSLMKPDPNLIW	DEGS1	31	O15121
PAIKALMRPDPRLKW	DEGS2	31	Q6QHC5
RAWWILMPIPTPLIM	DEFB109B	61	Q30KR1
RKPNLPKRWDMLTEP	CAPRIN2	396	Q6IMN6
MPRVSAPLVLLPAWL	GRIK4	1	Q16099
PWPLPVQMELGKLLA	POLRMT	566	O00411
IPPSARKPLCNWVRM	NPIPB6	221	E9PJ23
PVWVPKPSVDLKICM	CFAP74	801	Q9C0B2
MGTPKPRILPWLVSQ	IRF3	1	Q14653
IELLPRKGPSLWMAL	RNF139	116	Q8WU17
LMPFLAEELWQRLPP	VARS2	856	Q5ST30
RKFLLVTSMPWPIPL	SPEF2	1536	Q9C093
VLRPYPPWALLLMIT	SLC6A16	651	Q9GZN6
MLTKKAPPLVGRWVP	SFXN2	166	Q96NB2
MRPWKDPPSDLLLLK	F5	921	P12259
PMVWLDLQDRILPPM	FER1L5	1171	A0AVI2
ILPPMRWHPLVKELG	FER1L5	1181	A0AVI2
KPVMARPPLQWEKVA	PLEKHG3	941	A1L390
RLPLVPMLKWNHGLP	TAF1C	471	Q15572
WDAQAMPRLLEPPVL	TAF1	486	P21675
LPAMLKVRDPRPWLL	SLC39A4	606	Q6P5W5
VNPEPLRPETMWLAL	IQANK1	456	A8MXQ7
PLVIGMPQVLWPRIL	MROH2B	441	Q7Z745
SPAMIPKDWPLIIID	ERVK-9	1031	P63128
LLMWPLQEKPAPPRE	CD300A	236	Q9UGN4
MRWKPLALQPLIPRS	CNKSR2	311	Q8WXI2
LPSPAMIPKDWPLII	ERVK-25	106	P63136
WKVPGLPTPIENMIL	PRPF8	726	Q6P2Q9
ELMERATVPPLWPAL	TNRC18	871	O15417
LGPEWRLKLPSIPLV	TOMM34	136	Q15785
PTVIPILEEPWMVIK	ZNF287	216	Q9HBT7
MGDKIWLPFPVLLLA	TMED5	1	Q9Y3A6
MKALDSSRLVPWPPR	SPATA12	21	Q7Z6I5
VEAMPLRLLPAWKVP	STEAP3	201	Q658P3
EPVRIPLCKSLPWNM	FRZB	36	Q92765
RLLKMPADQLGLPWP	STKLD1	351	Q8NE28
LPSPAMIPKDWPLII	ERVK-10	106	P10266
LPSPAMIPKDWPLII	ERVK-8	106	P63133
PILIFLWAMLSVPRP	PIEZO2	1946	Q9H5I5
WQLAPLRKMGQPVLP	PHF3	851	Q92576
LPSPAMIPKDWPLII	ERVK-11	106	Q9UQG0
LNPSLMLPAWIMIEP	TECPR2	1246	O15040
LPKLPMNLLPKAWGV	VCPIP1	366	Q96JH7
CMWPRETQLLLEVPP	TNFRSF18	196	Q9Y5U5
MPWLLSAPKLVPAVA	XPNPEP3	1	Q9NQH7
PVLVFLWAMLSIPRP	PIEZO1	1711	Q92508
FVFIPMVVLWLIPVP	YIPF2	211	Q9BWQ6
EKRIPPWMEVVLIPM	POLR1B	586	Q9H9Y6
LAPPALCTVMLWEPL	VSIG10L2	401	P0DP72
CLLPLVMPLVRMPWK	PIGM	341	Q9H3S5
LSPPCFVRNLPWKIM	USP7	86	Q93009
MASAPWPERVPRLLA	TBPL2	1	Q6SJ96
MPLAQLKEPWPLMEL	RPS6KA1	1	Q15418
LKEPWPLMELVPLDP	RPS6KA1	6	Q15418
ILLPTTVPPATMRIW	ART4	11	Q93070