Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	extracellular matrix	TGFBI HSPG2 SMC3 FCN2 CSPG4 LAMA5 LOXL3 FGG RTN4RL2	2.64e-04	656	68	9	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	TGFBI HSPG2 SMC3 FCN2 CSPG4 LAMA5 LOXL3 FGG RTN4RL2	2.70e-04	658	68	9	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	TGFBI HSPG2 SMC3 FCN2 CSPG4 LAMA5 LOXL3 FGG	3.15e-04	530	68	8	GO:0062023
GeneOntologyCellularComponent	basement membrane	TGFBI HSPG2 SMC3 LAMA5	6.74e-04	122	68	4	GO:0005604
Domain	LAM_G_DOMAIN	HSPG2 FAT1 CSPG4 LAMA5	9.59e-06	38	66	4	PS50025
Domain	Laminin_G_2	HSPG2 FAT1 CSPG4 LAMA5	1.18e-05	40	66	4	PF02210
Domain	ZINC_FINGER_C2H2_2	TRERF1 ZXDC ZNF526 ZNF573 ZSCAN31 HELZ2 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	1.50e-05	775	66	12	PS50157
Domain	ZINC_FINGER_C2H2_1	TRERF1 ZXDC ZNF526 ZNF573 ZSCAN31 HELZ2 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	1.54e-05	777	66	12	PS00028
Domain	LamG	HSPG2 FAT1 CSPG4 LAMA5	1.74e-05	44	66	4	SM00282
Domain	Znf_C2H2-like	TRERF1 ZXDC ZNF526 ZNF573 ZSCAN31 HELZ2 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	1.95e-05	796	66	12	IPR015880
Domain	ZnF_C2H2	TRERF1 ZXDC ZNF526 ZNF573 ZSCAN31 HELZ2 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	2.26e-05	808	66	12	SM00355
Domain	-	TRERF1 ZXDC ZNF526 ZNF573 ZSCAN31 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	2.35e-05	679	66	11	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	TRERF1 ZXDC ZNF526 ZNF573 ZSCAN31 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	2.87e-05	694	66	11	IPR013087
Domain	Laminin_G	HSPG2 FAT1 CSPG4 LAMA5	5.23e-05	58	66	4	IPR001791
Domain	Znf_C2H2	TRERF1 ZXDC ZNF526 ZNF573 ZSCAN31 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	1.09e-04	805	66	11	IPR007087
Domain	zf-C2H2	TRERF1 ZNF526 ZNF573 ZSCAN31 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	1.49e-04	693	66	10	PF00096
Domain	LAMININ_IVA	HSPG2 LAMA5	3.40e-04	8	66	2	PS51115
Domain	Laminin_B	HSPG2 LAMA5	3.40e-04	8	66	2	PF00052
Domain	LamB	HSPG2 LAMA5	3.40e-04	8	66	2	SM00281
Domain	Laminin_IV	HSPG2 LAMA5	3.40e-04	8	66	2	IPR000034
Domain	-	HSPG2 FAT1 CSPG4 LAMA5	3.56e-04	95	66	4	2.60.120.200
Domain	Laminin_G_1	HSPG2 CSPG4	6.63e-04	11	66	2	PF00054
Domain	zf-C2H2_6	TRERF1 ZNF526 ZNF573 ZSCAN31 ZKSCAN8 ZNF646	8.38e-04	314	66	6	PF13912
Domain	DSRM	DROSHA ADAR	2.02e-03	19	66	2	SM00358
Domain	Fibrinogen_CS	FCN2 FGG	2.02e-03	19	66	2	IPR020837
Domain	dsrm	DROSHA ADAR	2.24e-03	20	66	2	PF00035
Domain	DS_RBD	DROSHA ADAR	2.47e-03	21	66	2	PS50137
Domain	Fibrinogen_a/b/g_C_2	FCN2 FGG	3.23e-03	24	66	2	IPR014715
Domain	-	FCN2 FGG	3.23e-03	24	66	2	4.10.530.10
Domain	-	DROSHA ADAR	4.08e-03	27	66	2	3.30.160.20
Domain	Fibrinogen_C	FCN2 FGG	4.08e-03	27	66	2	PF00147
Domain	dsRBD_dom	DROSHA ADAR	4.38e-03	28	66	2	IPR014720
Domain	FBG	FCN2 FGG	4.70e-03	29	66	2	SM00186
Domain	-	FCN2 FGG	5.02e-03	30	66	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	FCN2 FGG	5.02e-03	30	66	2	IPR014716
Domain	EGF_LAM_2	HSPG2 LAMA5	5.02e-03	30	66	2	PS50027
Domain	EGF_LAM_1	HSPG2 LAMA5	5.02e-03	30	66	2	PS01248
Domain	FIBRINOGEN_C_1	FCN2 FGG	5.70e-03	32	66	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	FCN2 FGG	5.70e-03	32	66	2	IPR002181
Domain	FIBRINOGEN_C_2	FCN2 FGG	5.70e-03	32	66	2	PS51406
Domain	Laminin_EGF	HSPG2 LAMA5	6.79e-03	35	66	2	PF00053
Domain	EGF_Lam	HSPG2 LAMA5	6.79e-03	35	66	2	SM00180
Domain	ConA-like_dom	HSPG2 FAT1 CSPG4 LAMA5	7.52e-03	219	66	4	IPR013320
Domain	Laminin_EGF	HSPG2 LAMA5	7.97e-03	38	66	2	IPR002049
Domain	LDLR_class-A_CS	DGCR2 HSPG2	8.80e-03	40	66	2	IPR023415
Domain	EGF	HSPG2 FAT1 LAMA5 ASTN1	9.58e-03	235	66	4	SM00181
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOXO3 ZXDC DGCR2 HSPG2 FAT1 SETD5 NEK8 MTG2 CSPG4 HELZ2 LAMA5 AMBRA1	1.41e-06	1105	68	12	35748872
Pubmed	Regulation of RNA editing by RNA-binding proteins in human cells.	DROSHA ADAR	3.77e-06	2	68	2	30652130
Pubmed	Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix.	HSPG2 SMC3	3.77e-06	2	68	2	8621634
Pubmed	Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.	HSPG2 CSPG4	3.77e-06	2	68	2	29462330
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	DGCR2 HSPG2 RPL27A FAT1 CSPG4 VPS35 PHB2 LAMA5 SRP68 LOXL3 ADAR USP6NL YARS2	4.06e-06	1451	68	13	30550785
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	TGFBI HSPG2 CSPG4 LAMA5 FGG	7.01e-06	135	68	5	28675934
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	RPL27A FAT1 DCAF8 VILL CROCC2 SAV1 TAF1L YARS2 ZNF646	7.76e-06	689	68	9	36543142
Pubmed	Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.	FOXO3 ASCL2 SAV1	1.59e-05	25	68	3	19786569
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	TGFBI HSPG2 CSPG4 LAMA5 FGG	1.96e-05	167	68	5	22159717
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RPL27A CSPG4 VPS35 SQLE ZKSCAN8 PHB2 ZNF696 USP3 USP6NL ZIC3 ZNF646	2.04e-05	1203	68	11	29180619
Pubmed	Proteoglycans and their roles in brain cancer.	HSPG2 CSPG4	2.25e-05	4	68	2	23281850
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	HSPG2 FAT1 HPD FCN2 AZU1 VPS35 LAMA5 PLCD1 CTNS FGG	2.71e-05	1016	68	10	19056867
Pubmed	Location of phosphorylase kinase (Phk) in the mouse X chromosome.	PLP1 ZIC3	3.75e-05	5	68	2	4726088
Pubmed	AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis.	FOXO3 AMBRA1	3.75e-05	5	68	2	30513302
Pubmed	Large-scale identification of genes implicated in kidney glomerulus development and function.	HSPG2 CSPG4 LAMA5	4.10e-05	34	68	3	16498405
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SETD5 HELZ2 ZFHX2 AMBRA1	4.92e-05	102	68	4	11214970
Pubmed	Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.	HSPG2 LAMA5	5.62e-05	6	68	2	15668394
Pubmed	Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.	CSPG4 PLP1	7.86e-05	7	68	2	23583582
Pubmed	The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis.	UBE2J2 SQLE	7.86e-05	7	68	2	35941365
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	HSPG2 VILL CAPN6 ZKSCAN8 LAMA5 ZNF112	7.87e-05	363	68	6	14691545
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	RPL27A GPBP1 SMC3 WDR6 SAV1 SRP68 ADAR	9.69e-05	547	68	7	37267103
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	AMBRA1 PLP1	1.34e-04	9	68	2	29252214
Pubmed	Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro.	HSPG2 CSPG4	1.34e-04	9	68	2	23320101
Pubmed	Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.	HSPG2 LAMA5	1.34e-04	9	68	2	30456378
Pubmed	BDNF+/- mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain.	CSPG4 PLP1	1.34e-04	9	68	2	20091777
Pubmed	Functional proteomics mapping of a human signaling pathway.	DGCR2 HSPG2 DROSHA CSPG4 VPS35 LAMA5 KIF13A	1.56e-04	591	68	7	15231748
Pubmed	Generation of a conditionally null allele of the laminin alpha1 gene.	HSPG2 LAMA5	1.68e-04	10	68	2	16100707
Pubmed	Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.	HSPG2 LAMA5	1.68e-04	10	68	2	16554364
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	RPL27A LEO1 SMC3 ZKSCAN8 PHB2 SRP68 ADAR	1.80e-04	605	68	7	28977666
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	TGFBI HSPG2 CSPG4 LAMA5	1.97e-04	146	68	4	27068509
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	DGCR2 RPL27A WDR6 DROSHA PHB2 SRP68 USP6NL	1.99e-04	615	68	7	31048545
Pubmed	Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor.	CSPG4 PLP1	2.05e-04	11	68	2	14602683
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	TGFBI HSPG2 LAMA5 FGG	2.36e-04	153	68	4	25037231
Pubmed	Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.	HSPG2 LAMA5	2.45e-04	12	68	2	10433923
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	HSPG2 LAMA5	2.45e-04	12	68	2	16750824
Pubmed	Mapping of loci and translocation breakpoints in Xq13: isolation of a conserved locus that maps close to CCG1 in human and mouse.	TAF1L PLP1	2.90e-04	13	68	2	8012115
Pubmed	Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.	HSPG2 LAMA5	2.90e-04	13	68	2	12682087
Pubmed	Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo.	HSPG2 CSPG4	2.90e-04	13	68	2	21839920
Pubmed	PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity.	HSPG2 CSPG4	2.90e-04	13	68	2	37936982
Pubmed	Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder.	CSPG4 PLP1	2.90e-04	13	68	2	30664625
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	HSPG2 LAMA5	3.38e-04	14	68	2	20858856
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	HSPG2 LAMA5	3.38e-04	14	68	2	19783738
Pubmed	Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.	LEO1 SETD5	3.38e-04	14	68	2	27864380
Pubmed	BMP signaling mutant mice exhibit glial cell maturation defects.	CSPG4 PLP1	3.38e-04	14	68	2	17391983
Pubmed	Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.	CSPG4 LAMA5	3.38e-04	14	68	2	22665518
Pubmed	Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.	WDR6 VPS35 PHB2 YARS2	3.60e-04	171	68	4	36629882
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	HSPG2 OTULIN DROSHA LAMA5 USP3 YARS2	3.60e-04	481	68	6	28190767
Pubmed	Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk.	CSPG4 PLP1	3.89e-04	15	68	2	33510480
Pubmed	Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease.	CSPG4 PLP1	3.89e-04	15	68	2	19739253
Pubmed	Basement membrane composition in the early mouse embryo day 7.	HSPG2 LAMA5	3.89e-04	15	68	2	15895400
Pubmed	Essential role of MESP1-RING1A complex in cardiac differentiation.	SMC3 ZIC3	3.89e-04	15	68	2	36413948
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	TGFBI HSPG2 LAMA5 FGG	3.92e-04	175	68	4	28071719
Pubmed	Ontogeny of stromal organizer cells during lymph node development.	HSPG2 LAMA5	4.44e-04	16	68	2	20237296
Pubmed	Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.	CSPG4 PLP1	4.44e-04	16	68	2	24257626
Pubmed	Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.	HSPG2 LAMA5	4.44e-04	16	68	2	17767158
Pubmed	Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.	HSPG2 LAMA5	4.44e-04	16	68	2	21067603
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	HSPG2 CSPG4	4.44e-04	16	68	2	16880404
Pubmed	Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.	CSPG4 PLP1	4.44e-04	16	68	2	25568100
Pubmed	Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.	DCAF8 FGG PLP1	4.54e-04	76	68	3	8288233
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FAT1 SETD5 WDR6 HELZ2 ADAR	4.90e-04	332	68	5	37433992
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	TGFBI HSPG2 LAMA5	5.08e-04	79	68	3	18757743
Pubmed	HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.	CSPG4 PLP1	5.65e-04	18	68	2	19503085
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	CSPG4 LAMA5	5.65e-04	18	68	2	14730302
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	CROCC2 VPS35 HELZ2 PLCD1 FGG CPLANE1 ADAR	5.66e-04	732	68	7	34732716
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	TGFBI HSPG2 FGG	6.51e-04	86	68	3	28327460
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	HSPG2 LEO1 SRP68 TAF1L	6.85e-04	203	68	4	22083510
Pubmed	Oligodendrocyte precursors migrate along vasculature in the developing nervous system.	CSPG4 PLP1	7.00e-04	20	68	2	26798014
Pubmed	Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.	DCAF8 AMBRA1	7.00e-04	20	68	2	31155351
Pubmed	Regulation of the endosomal SNX27-retromer by OTULIN.	OTULIN USP3	7.72e-04	21	68	2	31541095
Pubmed	Schwann cell myelination requires integration of laminin activities.	HSPG2 LAMA5	7.72e-04	21	68	2	22767514
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	HSPG2 LAMA5	7.72e-04	21	68	2	27856617
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	TGFBI SMC3 CSPG4 FGFR4	7.78e-04	210	68	4	16537572
Pubmed	SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.	CSPG4 PLP1	8.48e-04	22	68	2	17084361
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	HSPG2 ZIC3	8.48e-04	22	68	2	18448648
Pubmed	PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA.	CSPG4 PLP1	8.48e-04	22	68	2	38507412
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	ZXDC ZNF526 SETD5 CSPG4	8.78e-04	217	68	4	34048709
Pubmed	Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.	TGFBI HSPG2 LAMA5	9.24e-04	97	68	3	27559042
Pubmed	Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.	FGG PLP1	9.28e-04	23	68	2	9143490
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	NEK8 LAMA5 CPLANE1	1.01e-03	100	68	3	25807483
Pubmed	Proteomics characterization of extracellular space components in the human aorta.	TGFBI HSPG2 LAMA5	1.04e-03	101	68	3	20551380
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	FOXO3 LEO1 SMC3 SETD5 NEK8 PHB2 SAV1 SRP68 AMBRA1	1.05e-03	1321	68	9	27173435
Pubmed	Rheb1 is required for mTORC1 and myelination in postnatal brain development.	CSPG4 PLP1	1.10e-03	25	68	2	21238928
Pubmed	Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation.	CSPG4 PLP1	1.10e-03	25	68	2	32266943
Pubmed	Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.	TGFBI FOXO3	1.10e-03	25	68	2	23906066
Pubmed	Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.	HSPG2 LAMA5	1.10e-03	25	68	2	19373938
Pubmed	An empirical framework for binary interactome mapping.	DCAF8 GPBP1 SETD5 ZNF646	1.11e-03	231	68	4	19060904
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	RPL27A SMC3 WDR6 ASCL2 VPS35 PHB2 SRP68 ADAR YARS2	1.13e-03	1335	68	9	29229926
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	VPS35 KIF13A ARHGEF17 ADAR	1.16e-03	234	68	4	36243803
Pubmed	The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.	CSPG4 PLP1	1.19e-03	26	68	2	25810530
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DCAF8 OTULIN MTG2 VPS35 SAV1 AMBRA1	1.20e-03	606	68	6	36538041
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RPL27A SMC3 WDR6 VPS35 PHB2 SRP68 AMBRA1 ADAR USP3	1.24e-03	1353	68	9	29467282
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF526 FAT1 DCAF8 SETD5 WDR6 DROSHA AMBRA1 ZNF646	1.47e-03	1116	68	8	31753913
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	HSPG2 LAMA5	1.48e-03	29	68	2	22613833
Pubmed	CRL4AMBRA1 is a master regulator of D-type cyclins.	DCAF8 AMBRA1	1.58e-03	30	68	2	33854235
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	DCAF8 AMBRA1	1.58e-03	30	68	2	34017080
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	RPL27A WDR6 VPS35 SAV1 FGFR4	1.58e-03	432	68	5	23455922
Pubmed	Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.	FOXO3 AMBRA1 PLP1	1.59e-03	117	68	3	12107410
Pubmed	Network organization of the human autophagy system.	FOXO3 SMC3 PHB2 SAV1 AMBRA1	1.67e-03	437	68	5	20562859
Pubmed	WNT5a-ROR Signaling Is Essential for Alveologenesis.	TGFBI CSPG4	1.69e-03	31	68	2	32046118
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	HSPG2 LAMA5	1.69e-03	31	68	2	22274697
Interaction	SIRPD interactions	DGCR2 HSPG2 CSPG4 LAMA5 FGFR4	1.06e-05	86	68	5	int:SIRPD
GeneFamily	Blood group antigens\|CD molecules\|Proteoglycans	HSPG2 SMC3 CSPG4	5.36e-07	7	46	3	570
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZXDC ZNF526 ZNF573 ZSCAN31 ZKSCAN8 ZNF696 ZFHX2 ZNF112 ZIC3 ZNF646	1.02e-05	718	46	10	28
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF8 AMBRA1	9.44e-04	18	46	2	498
GeneFamily	Fibrinogen C domain containing	FCN2 FGG	1.83e-03	25	46	2	554
Coexpression	GSE1740_UNSTIM_VS_IFNA_STIMULATED_MCSF_IFNG_DERIVED_MACROPHAGE_UP	ADCY4 FAT1 HELZ2 KIF13A ARHGEF17 ITK	1.14e-05	194	68	6	M6159
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 CSPG4 CAPN6 ASTN1 LOXL3 PLP1	3.59e-07	182	68	6	a1c0e4090a9e7aa4941a40c817d178de144888b6
Disease	FEV/FEC ratio	FOXO3 CACNA1D HSPG2 DCAF8 ZSCAN31 CROCC2 CSPG4 FGFR4 KIF13A ARHGEF17 USP3	1.08e-04	1228	68	11	EFO_0004713
Disease	Cornelia De Lange Syndrome	SMC3 SETD5	1.45e-04	8	68	2	C0270972
Disease	Experimental Autoimmune Encephalomyelitis	FOXO3 PLP1	1.86e-04	9	68	2	C0014072
Disease	Hodgkins lymphoma	ZNF526 CPLANE1 RTN4RL2	9.10e-04	82	68	3	EFO_0000183
Disease	Adenocarcinoma of lung (disorder)	FOXO3 RPL27A FGFR4 TAF1L	1.33e-03	206	68	4	C0152013
Disease	Adenoid Cystic Carcinoma	FOXO3 FAT1 FGFR4	1.61e-03	100	68	3	C0010606
Disease	oral squamous cell carcinoma (is_implicated_in)	FAT1 FGFR4	1.90e-03	28	68	2	DOID:0050866 (is_implicated_in)
Disease	Ciliopathies	NEK8 CPLANE1 ZIC3	2.12e-03	110	68	3	C4277690

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLVLQHSRLRGRQHG	TGFBI	31	Q15582
GGTQQDGFHFRAHLQ	CSPG4	1791	Q6UVK1
FHGENRIGGIRLRHQ	FGFR4	191	P22455
HSFNNFRLRVGLNHG	ADCY4	976	Q8NFM4
GGFGNNIIVSHRIHR	AMBRA1	1176	Q9C0C7
GHGRESLRNARVQGH	ASTN1	211	O14525
VNLGFQALRQHVPHG	ASCL2	66	Q99929
HGNRLQGVHRAAFRG	RTN4RL2	211	Q86UN3
QQVARAVLHVHGGGG	HSPG2	1941	P98160
GQGHTGHVRFLAAVQ	ARHGEF17	1966	Q96PE2
FFGGHIRQQGTRHGR	FAT1	3951	Q14517
GDHNHLFIRQGTGLQ	LEO1	466	Q8WVC0
RLLAQRQQHSFGLHG	LOXL3	231	P58215
HGRNGTENINHRGGY	GPBP1	76	Q86WP2
QRFRLQHGLEGHTGC	DCAF8	181	Q5TAQ9
GSNQHGQLGTNTRRG	NEK8	586	Q86SG6
HVHRGQLQLVEGNFR	LAMA5	1756	O15230
GHRAIFFNRIGGVQQ	PHB2	46	Q99623
GNGFVRHNVGHLSRI	PLCD1	536	P51178
QLLRNHLNQVGHTGG	OTULIN	271	Q96BN8
NRLTIGEGQQHHLGG	FGG	416	P02679
GVHLRSQGLQRGFQH	ADAR	96	P55265
PRGENQHGHSFLINR	CPLANE1	3006	Q9H799
RQQAHLGQAFQTGHA	CROCC2	1636	H7BZ55
HVSNLNGRYLRGTHG	FCN2	271	Q15485
NQVQSGRAFHHGRFI	SQLE	216	Q14534
SLIGANLHHFNLGRR	DGCR2	381	P98153
LHGNHSNQTGPRIRF	CTNS	101	O60931
ELHINGQRLQHQTGF	CCDC168	1506	Q8NDH2
LHRTELHVNIGGQGR	CCDC168	5396	Q8NDH2
ARGHQQQGGHYSLQV	HELZ2	1651	Q9BYK8
GNISNHQLTQGRLGH	CAPN6	66	Q9Y6Q1
NQGRHFCGGALIHAR	AZU1	46	P20160
RNGALLGNHVNHVNS	CACNA1D	1681	Q01668
GRGNAGGLHHHRINF	RPL27A	31	P46776
NYHQHNGGGLVTRLR	ITK	321	Q08881
NTGGIFQLRQGHSRR	KIF13A	1016	Q9H1H9
LFLEVIQRHNHQGFG	HPD	346	P32754
HQHQTQGALGGSRAL	FOXO3	536	O43524
RTVGFNHLTLGHNQR	DROSHA	1131	Q9NRR4
HQFSHAGRSNGRGLI	NABP1	161	Q96AH0
RKGINQHVQNGYHGI	SMC3	521	Q9UQE7
LGLFHLQRAGHNVIA	YARS2	96	Q9Y2Z4
QQGLRGTFGGNIIQH	TAF1L	596	Q8IZX4
HRGSGGVHQYRLQPL	SETD5	1416	Q9C0A6
AHQNRGLGSAFLRHI	MTG2	286	Q9H4K7
QQHGLRHGDFQRYRG	SRP68	71	Q9UHB9
RVPQAGGQHARGQHA	ADGRG5	96	Q8IZF4
QNQGRHASGIGRVAA	SAV1	171	Q9H4B6
TGHVDNNQVHLGLRG	ZIC3	176	O60481
GVHHLSNGQRSVGRP	USP6NL	381	Q92738
IQNAGLFQHLRVHTG	ZSCAN31	361	Q96LW9
QLKVHLLTHGGGQGR	ZXDC	191	Q2QGD7
CGRAFSQGGHLRIHQ	ZNF573	251	Q86YE8
QLLLNGFHHVGAPAR	ZFHX2	661	Q9C0A1
NTARKHFGAGGNQRI	VPS35	511	Q96QK1
GGNGFLRFRQHQEVQ	SPDYC	46	Q5MJ68
QANRHHGLLGGALAN	UBE2J2	221	Q8N2K1
GQSFNLLRHQRVHTG	ZNF696	191	Q9H7X3
FNRQHGGVAGHDLNS	ZBED8	51	Q8IZ13
RAHHRPRQGVGENGQ	ZNF646	421	O15015
GRVQNIGHCFGHSAR	WDR6	246	Q9NNW5
QGQLVIFQERAGHHG	VILL	486	O15195
GKGFNHRSVLNVHQR	ZNF112	531	Q9UJU3
HLHLELQGGFNGVSR	USP3	271	Q9Y6I4
SANRLQAHGRAHVGG	ZNF526	316	Q8TF50
QGHRQAQTRQSHGEG	RPTN	686	Q6XPR3
AFNGNTGLIQHLRIH	ZKSCAN8	526	Q15776
SRQALNGHARIHGGT	TRERF1	1026	Q96PN7
QKGRGSRGQHQAHSL	PLP1	121	P60201