Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	STARD13 ARHGEF28 SIPA1L3 PSD3 ARHGEF18 GMIP ARHGEF11 RASA4 FARP1 RASA4B RIMS1 PLCG1 ARHGEF3 PLXNB1	1.19e-06	507	114	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	STARD13 ARHGEF28 SIPA1L3 PSD3 ARHGEF18 GMIP ARHGEF11 RASA4 FARP1 RASA4B RIMS1 PLCG1 ARHGEF3 PLXNB1	1.19e-06	507	114	14	GO:0030695
GeneOntologyMolecularFunction	glucokinase activity	HK1 HK3	3.19e-04	5	114	2	GO:0004340
GeneOntologyMolecularFunction	hexokinase activity	HK1 HK3	3.19e-04	5	114	2	GO:0004396
GeneOntologyMolecularFunction	fructokinase activity	HK1 HK3	3.19e-04	5	114	2	GO:0008865
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	ARHGEF28 PSD3 ARHGEF18 ARHGEF11 FARP1 PLCG1 ARHGEF3	3.65e-04	231	114	7	GO:0005085
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	STARD13 SPRY2 ARHGEF28 SIPA1L3 PSD3 ARHGEF18 GMIP ARHGEF11 SH2B2 RASA4 RASA4B ARHGEF3 PLXNB1	4.47e-08	333	115	13	GO:0051056
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	STARD13 SPRY2 ARHGEF28 SIPA1L3 PSD3 ARHGEF18 GMIP ARHGEF11 SH2B2 RASA4 FARP1 RASA4B ARHGEF3 PLXNB1	1.82e-06	538	115	14	GO:0007264
GeneOntologyCellularComponent	Cul4-RING E3 ubiquitin ligase complex	DCAF8L2 AMBRA1 DCAF8L1 DCAF4	5.55e-05	38	115	4	GO:0080008
GeneOntologyCellularComponent	basement membrane	HSPG2 FRAS1 TNC ACHE DST ACAN	5.85e-05	122	115	6	GO:0005604
GeneOntologyCellularComponent	Golgi lumen	HSPG2 MUC19 MUC16 MUC12 ACAN	3.42e-04	109	115	5	GO:0005796
GeneOntologyCellularComponent	actomyosin	NEBL SIPA1L3 MYO18A SH2B2 DST	4.74e-04	117	115	5	GO:0042641
MousePheno	abnormal optic nerve morphology	PPFIA2 BACH2 DPP3 NSUN2 EHBP1L1 BARHL2 PARD3 GDF11	1.87e-05	182	88	8	MP:0001330
Domain	-	ARHGEF28 PSD3 ARHGEF18 ARHGEF11 SH2B2 SHC3 RASA4 FARP1 RASA4B PLCG1 ARHGEF3 EPB41L1	3.66e-06	391	111	12	2.30.29.30
Domain	PH	ARHGEF28 PSD3 ARHGEF18 ARHGEF11 SH2B2 RASA4 FARP1 RASA4B PLCG1 ARHGEF3	6.24e-06	278	111	10	SM00233
Domain	PH_DOMAIN	ARHGEF28 PSD3 ARHGEF18 ARHGEF11 SH2B2 RASA4 FARP1 RASA4B PLCG1 ARHGEF3	6.44e-06	279	111	10	PS50003
Domain	PH_domain	ARHGEF28 PSD3 ARHGEF18 ARHGEF11 SH2B2 RASA4 FARP1 RASA4B PLCG1 ARHGEF3	6.65e-06	280	111	10	IPR001849
Domain	PH_dom-like	ARHGEF28 PSD3 ARHGEF18 ARHGEF11 SH2B2 SHC3 RASA4 FARP1 RASA4B PLCG1 ARHGEF3 EPB41L1	8.73e-06	426	111	12	IPR011993
Domain	LRRFIP1/2	LRRFIP1 LRRFIP2	3.50e-05	2	111	2	IPR019139
Domain	LRRFIP	LRRFIP1 LRRFIP2	3.50e-05	2	111	2	PF09738
Domain	DH_1	ARHGEF28 ARHGEF18 ARHGEF11 FARP1 ARHGEF3	3.62e-05	63	111	5	PS00741
Domain	RhoGEF	ARHGEF28 ARHGEF18 ARHGEF11 FARP1 ARHGEF3	5.24e-05	68	111	5	SM00325
Domain	RhoGEF	ARHGEF28 ARHGEF18 ARHGEF11 FARP1 ARHGEF3	6.03e-05	70	111	5	PF00621
Domain	DH_2	ARHGEF28 ARHGEF18 ARHGEF11 FARP1 ARHGEF3	6.03e-05	70	111	5	PS50010
Domain	-	ARHGEF28 ARHGEF18 ARHGEF11 FARP1 ARHGEF3	6.45e-05	71	111	5	1.20.900.10
Domain	DH-domain	ARHGEF28 ARHGEF18 ARHGEF11 FARP1 ARHGEF3	6.45e-05	71	111	5	IPR000219
Domain	PH	PSD3 ARHGEF18 SH2B2 RASA4 FARP1 RASA4B PLCG1 ARHGEF3	6.75e-05	229	111	8	PF00169
Domain	-	RASA4 RASA4B	1.05e-04	3	111	2	4.10.1130.10
Domain	RasGAP_dom	RASA4 RASA4B PLXNB1	1.56e-04	18	111	3	IPR001936
Domain	Rho_GTPase_activation_prot	STARD13 GMIP RASA4 RASA4B PLXNB1	1.79e-04	88	111	5	IPR008936
Domain	SEA	HSPG2 MUC16 MUC12	2.90e-04	22	111	3	PF01390
Domain	SEA	HSPG2 MUC16 MUC12	3.32e-04	23	111	3	PS50024
Domain	SEA_dom	HSPG2 MUC16 MUC12	3.32e-04	23	111	3	IPR000082
Domain	Hexokinase_2	HK1 HK3	3.46e-04	5	111	2	PF03727
Domain	Hexokinase_BS	HK1 HK3	3.46e-04	5	111	2	IPR019807
Domain	Hexokinase_C	HK1 HK3	3.46e-04	5	111	2	IPR022673
Domain	Hexokinase_N	HK1 HK3	3.46e-04	5	111	2	IPR022672
Domain	Hexokinase_1	HK1 HK3	3.46e-04	5	111	2	PF00349
Domain	HEXOKINASE_2	HK1 HK3	3.46e-04	5	111	2	PS51748
Domain	HEXOKINASE_1	HK1 HK3	3.46e-04	5	111	2	PS00378
Domain	C2_dom	DNAJC6 RASA4 RASA4B PKN1 RIMS1 PLCG1	4.43e-04	164	111	6	IPR000008
Domain	Hexokinase	HK1 HK3	5.17e-04	6	111	2	IPR001312
Domain	BTK	RASA4 RASA4B	1.23e-03	9	111	2	SM00107
Domain	Cl-channel_core	CLCN2 CLCN6	1.23e-03	9	111	2	IPR014743
Domain	-	CLCN2 CLCN6	1.23e-03	9	111	2	1.10.3080.10
Domain	Voltage_CLC	CLCN2 CLCN6	1.23e-03	9	111	2	PF00654
Domain	Cl-channel_volt-gated	CLCN2 CLCN6	1.23e-03	9	111	2	IPR001807
Domain	Znf_Btk_motif	RASA4 RASA4B	1.23e-03	9	111	2	IPR001562
Domain	BTK	RASA4 RASA4B	1.23e-03	9	111	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	1.23e-03	9	111	2	PS51113
Domain	C2	RASA4 RASA4B PKN1 RIMS1 PLCG1	1.36e-03	137	111	5	SM00239
Domain	PAS_9	KCNH7 KCNH8	1.53e-03	10	111	2	PF13426
Domain	PDZ	SIPA1L3 MYO18A ARHGEF11 RIMS1 PARD3	1.54e-03	141	111	5	PF00595
Domain	C2	RASA4 RASA4B PKN1 RIMS1 PLCG1	1.59e-03	142	111	5	PS50004
Domain	GDS_CDC24_CS	ARHGEF11 FARP1 ARHGEF3	1.60e-03	39	111	3	IPR001331
Domain	-	RASA4 RASA4B PKN1 RIMS1 PLCG1	1.91e-03	148	111	5	2.60.40.150
Domain	PDZ	SIPA1L3 MYO18A ARHGEF11 RIMS1 PARD3	1.91e-03	148	111	5	SM00228
Domain	-	SIPA1L3 MYO18A ARHGEF11 RIMS1 PARD3	2.02e-03	150	111	5	2.30.42.10
Domain	PDZ	SIPA1L3 MYO18A ARHGEF11 RIMS1 PARD3	2.08e-03	151	111	5	PS50106
Domain	PDZ	SIPA1L3 MYO18A ARHGEF11 RIMS1 PARD3	2.14e-03	152	111	5	IPR001478
Domain	FA	FARP1 EPB41L1	2.62e-03	13	111	2	PF08736
Domain	FERM-adjacent	FARP1 EPB41L1	2.62e-03	13	111	2	IPR014847
Domain	FA	FARP1 EPB41L1	2.62e-03	13	111	2	SM01195
Domain	RasGAP	RASA4 RASA4B	3.04e-03	14	111	2	SM00323
Domain	SEA	HSPG2 MUC16	3.04e-03	14	111	2	SM00200
Domain	K_chnl_volt-dep_EAG/ELK/ERG	KCNH7 KCNH8	3.04e-03	14	111	2	IPR003938
Domain	RasGAP_CS	RASA4 RASA4B	3.04e-03	14	111	2	IPR023152
Domain	RasGAP	RASA4 RASA4B	3.49e-03	15	111	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	3.49e-03	15	111	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	3.49e-03	15	111	2	PS50018
Domain	-	DCAF8L2 AMBRA1 WRAP53 DCAF8L1 DCAF4 PLXNB1 WDR24	3.75e-03	333	111	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DCAF8L2 AMBRA1 WRAP53 DCAF8L1 DCAF4 PLXNB1 WDR24	3.88e-03	335	111	7	IPR015943
Domain	CBS	CLCN2 CLCN6	3.98e-03	16	111	2	SM00116
Domain	-	RASA4 RASA4B	3.98e-03	16	111	2	1.10.506.10
Domain	Cadherin_CS	DCHS2 PCDHGA10 FAT1 CDHR4	4.07e-03	109	111	4	IPR020894
Domain	WD40	DCAF8L2 AMBRA1 WRAP53 DCAF8L1 DCAF4 WDR24	4.52e-03	259	111	6	PF00400
Domain	CADHERIN_1	DCHS2 PCDHGA10 FAT1 CDHR4	4.63e-03	113	111	4	PS00232
Domain	Cadherin	DCHS2 PCDHGA10 FAT1 CDHR4	4.63e-03	113	111	4	PF00028
Domain	CADHERIN_2	DCHS2 PCDHGA10 FAT1 CDHR4	4.78e-03	114	111	4	PS50268
Domain	-	DCHS2 PCDHGA10 FAT1 CDHR4	4.78e-03	114	111	4	2.60.40.60
Domain	CA	DCHS2 PCDHGA10 FAT1 CDHR4	4.93e-03	115	111	4	SM00112
Domain	Cadherin-like	DCHS2 PCDHGA10 FAT1 CDHR4	5.08e-03	116	111	4	IPR015919
Domain	WD40	DCAF8L2 AMBRA1 WRAP53 DCAF8L1 DCAF4 WDR24	5.33e-03	268	111	6	SM00320
Domain	Cadherin	DCHS2 PCDHGA10 FAT1 CDHR4	5.40e-03	118	111	4	IPR002126
Domain	VWC_out	FRAS1 MUC19	5.60e-03	19	111	2	SM00215
Domain	WD40_repeat	DCAF8L2 AMBRA1 WRAP53 DCAF8L1 DCAF4 WDR24	5.72e-03	272	111	6	IPR001680
Pathway	REACTOME_RHOA_GTPASE_CYCLE	STARD13 ARHGEF28 ARHGEF18 GMIP ARHGEF11 FARP1 PKN1 ARHGEF3	1.82e-06	142	83	8	MM15576
Pathway	REACTOME_RHOA_GTPASE_CYCLE	STARD13 ARHGEF28 ARHGEF18 GMIP ARHGEF11 FARP1 PKN1 ARHGEF3	2.61e-06	149	83	8	M41805
Pathway	PID_RHOA_REG_PATHWAY	ARHGEF28 ARHGEF18 ARHGEF11 FARP1 ARHGEF3	7.10e-06	46	83	5	M68
Pathway	REACTOME_RHO_GTPASE_CYCLE	STARD13 ARHGEF28 ARHGEF18 GMIP ARHGEF11 SENP1 DST FARP1 PKN1 ARHGEF3 PLXNB1	5.05e-05	439	83	11	MM15595
Pathway	REACTOME_RHOB_GTPASE_CYCLE	STARD13 ARHGEF28 ARHGEF11 PKN1 ARHGEF3	5.24e-05	69	83	5	MM15596
Pathway	REACTOME_RHOB_GTPASE_CYCLE	STARD13 ARHGEF28 ARHGEF11 PKN1 ARHGEF3	5.62e-05	70	83	5	M41806
Pathway	REACTOME_RHO_GTPASE_CYCLE	STARD13 ARHGEF28 ARHGEF18 GMIP ARHGEF11 SENP1 DST FARP1 PKN1 ARHGEF3 PLXNB1	6.31e-05	450	83	11	M27078
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SIN3B SYNE1 SIPA1L3 HECTD4 ARHGEF18 BCOR ARHGEF11 DNAJC6 SENP1 DST AP2A2 FARP1 SMARCC2 PKN1 RIMS1 PARD3 EPB41L1 LRRFIP1 LRRFIP2	7.71e-10	963	119	19	28671696
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 SPRY2 FRAS1 SZT2 SIPA1L3 HECTD4 AMBRA1 WRAP53 ARHGEF11 STK11IP SH2B2 RNF43 MXD4 FAT1 EHBP1L1 DST PKN1 PLCG1 HECTD1 WDR24	1.16e-09	1105	119	20	35748872
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PPAN ZC3H13 ZMYND8 FNBP4 MYO18A RREB1 WRAP53 BCOR YTHDC1 NSUN2 TAF3 SMARCC2 PKN1 RIMS1 PARD3 LRRFIP1	9.94e-09	774	119	16	15302935
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	HK1 TNC SYNE1 PPFIA2 SIPA1L3 MYO18A PSD3 ARHGEF11 DNAJC6 DST CLCN6 AP2A2 FARP1 SMARCC2 RIMS1 MTDH EPB41L1 LRRFIP1 LRRFIP2	4.09e-07	1431	119	19	37142655
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZBTB38 HK1 SYNE1 ZC3H13 ZMYND8 HECTD4 FNBP4 MYO18A YTHDC1 TAF3 EHBP1L1 DST FARP1 SMARCC2 MTDH PLXNB1	9.24e-07	1082	119	16	38697112
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PRRG1 HBS1L HK3 ZC3H13 ZNF212 TTC14 ARHGEF18 TACC2 BCOR FARP1 PLCG1 ARHGEF3 PARD3 TAPBP MTDH PLXNB1	9.46e-07	1084	119	16	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SIN3B HBS1L ARHGEF28 SIPA1L3 TTC14 ARHGEF18 VARS2 ENPP4 YTHDC1 AP2A2 HECTD1	1.11e-06	493	119	11	15368895
Pubmed	Dynamic expression patterns of ECM molecules in the developing mouse olfactory pathway.	HSPG2 TNC ACAN	3.23e-06	9	119	3	18570250
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SIN3B HBS1L PPAN NEBL NOP53 SYNE1 SIPA1L3 ZMYND8 WRAP53 BCOR ARHGEF11 YTHDC1 DST FARP1 PARD3 EPN1 TAPBP EPB41L1	3.45e-06	1497	119	18	31527615
Pubmed	Acetylcholinesterase activity in the brain of dystonia musculorum (Dst(dt-J)) mutant mice.	ACHE DST	1.16e-05	2	119	2	21978551
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	1.16e-05	2	119	2	11448776
Pubmed	Evidence of a dosage effect and a physiological endplate acetylcholinesterase deficiency in the first mouse models mimicking Schwartz-Jampel syndrome neuromyotonia.	HSPG2 ACHE	1.16e-05	2	119	2	18647752
Pubmed	Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression.	ACHE BACH2	1.16e-05	2	119	2	16832351
Pubmed	Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.	SIRT6 ACAN	1.16e-05	2	119	2	33600943
Pubmed	Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.	TNC ACAN	1.16e-05	2	119	2	7524681
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	1.16e-05	2	119	2	16041389
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CUX2 SYNE1 SIPA1L3 PSD3 DST CLCN6 AP2A2	1.31e-05	225	119	7	12168954
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	HBS1L FRAS1 PPAN HK1 NOP53 SIRT6 WRAP53 ZNF469 AP2A2 PLCG1 MTDH	1.59e-05	653	119	11	33742100
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TNC ARHGEF18 AP2A2 FARP1 PARD3 MTDH	1.88e-05	159	119	6	30581152
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	PPAN ZC3H13 FNBP4 HTATSF1 SMARCC2 MTDH	2.17e-05	163	119	6	22113938
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	HBS1L PPAN HECTD4 FNBP4 AMBRA1 SIRT6 NSUN2 SMARCC2 HECTD1	2.17e-05	440	119	9	34244565
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC19 MUC16 MUC12	3.07e-05	18	119	3	18834073
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ARHGEF18 ARHGEF11 ARHGEF3	3.07e-05	18	119	3	12799088
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STARD13 CUX2 PPAN HK1 PCDHGA10 SYNE1 PPFIA2 SIPA1L3 MYO18A KRBA2 DST STS AP2A2 SMARCC2 RIMS1 MTDH	3.38e-05	1442	119	16	35575683
Pubmed	[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].	HK1 HK3	3.47e-05	3	119	2	26855992
Pubmed	Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development.	HSPG2 ACAN	3.47e-05	3	119	2	19669783
Pubmed	Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.	ARHGEF11 PLXNB1	3.47e-05	3	119	2	12220504
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	3.47e-05	3	119	2	25637021
Pubmed	Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex.	DNAJC6 AP2A2	3.47e-05	3	119	2	11470803
Pubmed	Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.	RASA4 PLCG1	3.47e-05	3	119	2	12845332
Pubmed	SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170.	SIRT6 SMARCC2	3.47e-05	3	119	2	31216030
Pubmed	Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.	MUC16 MUC12	3.47e-05	3	119	2	26770020
Pubmed	Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.	CLCN2 CLCN6	3.47e-05	3	119	2	11306429
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 TTC14 DST	4.27e-05	20	119	3	21689717
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	ZMYND8 MUC19 BCOR SENP1 DST	6.75e-05	123	119	5	26912792
Pubmed	Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.	HK1 HK3	6.93e-05	4	119	2	25904018
Pubmed	An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.	HSPG2 ACAN	6.93e-05	4	119	2	26428891
Pubmed	Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.	LRRFIP1 LRRFIP2	6.93e-05	4	119	2	19265123
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	6.93e-05	4	119	2	21460216
Pubmed	High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.	HK1 HK3	6.93e-05	4	119	2	25766729
Pubmed	Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system.	LRRFIP1 LRRFIP2	6.93e-05	4	119	2	10366446
Pubmed	Formation and contraction of multicellular actomyosin cables facilitate lens placode invagination.	ARHGEF11 PARD3	6.93e-05	4	119	2	32113830
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	6.93e-05	4	119	2	16234249
Pubmed	Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.	DCHS2 TNC FAT1	7.50e-05	24	119	3	26116661
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	HBS1L FRAS1 ARHGEF28 AMBRA1 GMIP NSUN2 DST EPN1 EPB41L1 PLXNB1	8.32e-05	650	119	10	38777146
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SZT2 ZNF212 HECTD4 FNBP4 AMBRA1 BCOR DST CEP126 PLXNB1	8.96e-05	529	119	9	14621295
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	HSPG2 SYNE1 PPFIA2 SH2B2 PKN1 MTDH	9.85e-05	214	119	6	22199357
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	SIPA1L3 FNBP4 TACC2 PSMD12 YTHDC1 DNAJC6 PARD3 HECTD1 EPB41L1	9.90e-05	536	119	9	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	SIPA1L3 FNBP4 TACC2 PSMD12 YTHDC1 DNAJC6 PARD3 HECTD1 EPB41L1	1.02e-04	538	119	9	10512203
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	PPAN NOP53 SIPA1L3 PSMD12 NSUN2 AP2A2 MTDH	1.12e-04	316	119	7	31665637
Pubmed	Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.	SPRY2 PLCG1	1.15e-04	5	119	2	20719962
Pubmed	Spatial and temporal changes in chondroitin sulfate distribution in the sclerotome play an essential role in the formation of migration patterns of mouse neural crest cells.	HSPG2 TNC	1.15e-04	5	119	2	9915576
Pubmed	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.	AP2A2 EPN1	1.15e-04	5	119	2	9723620
Pubmed	Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.	ARHGEF11 PLXNB1	1.15e-04	5	119	2	12183458
Pubmed	Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation.	PKN1 PLCG1	1.15e-04	5	119	2	15123640
Pubmed	Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.	HBS1L TAF3	1.15e-04	5	119	2	23935956
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF212 BACH2 ZMYND8 AMBRA1 RREB1 BCOR RNF43 ZNF469 FAT1 SENP1 TAF3 SMARCC2 PARD3	1.20e-04	1116	119	13	31753913
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SPRY2 DCHS2 ZBTB38 SYNE1 SIPA1L3 ZMYND8 HECTD4 CRTAC1 WRAP53 NSUN2 DST PLCG1 HECTD1 LRRFIP1	1.31e-04	1285	119	14	35914814
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	KCNH7 PPFIA2 MYO18A PSD3 TACC2 PSMD12 AP2A2 FARP1 SMARCC2 RIMS1 MTDH EPB41L1 LRRFIP1	1.47e-04	1139	119	13	36417873
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	PPFIA2 HECTD4 MYO18A PSD3 ARHGEF18	1.56e-04	147	119	5	16959763
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	SPRY2 PLCG1	1.73e-04	6	119	2	21762810
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC19 MUC16	1.73e-04	6	119	2	19110483
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN2 CLCN6	1.73e-04	6	119	2	10198195
Pubmed	Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin.	DNAJC6 AP2A2	1.73e-04	6	119	2	12732633
Pubmed	Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch).	HSPG2 ACAN	1.73e-04	6	119	2	9486530
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	FRAS1 HK1 SYNE1 ZC3H13 FNBP4 MYO18A PSD3 VARS2 DNAJC6 SENP1 FARP1 HTATSF1 PARD3 MTDH EPB41L1	1.73e-04	1487	119	15	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KCNH8 PPFIA2 SIPA1L3 HECTD4 TTC14 FNBP4 ARHGEF18 SENP1 FARP1 PKN1 RIMS1 PLCG1 PARD3 HECTD1 EPB41L1	1.76e-04	1489	119	15	28611215
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	TNC PPFIA2 MYO18A DNAJC6 DST RIMS1 EPB41L1	2.00e-04	347	119	7	17114649
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	GMIP NSUN2 HTATSF1 SMARCC2 PKN1 EPB41L1	2.10e-04	246	119	6	15345747
Pubmed	Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule.	ZNF142 TNC ACAN	2.36e-04	35	119	3	15031101
Pubmed	Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.	SPRY2 CUX2 CRTAC1	2.36e-04	35	119	3	22991445
Pubmed	Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers.	HSPG2 ACHE	2.41e-04	7	119	2	25042397
Pubmed	The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.	SPRY2 PLCG1	2.41e-04	7	119	2	11983899
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT1	2.41e-04	7	119	2	16059920
Pubmed	Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.	SHC3 PLCG1	2.41e-04	7	119	2	12074588
Pubmed	Comprehensive Characterization of Tissues Derived from Animals at Different Regenerative Stages: A Comparative Analysis between Fetal and Adult Mouse Skin.	HSPG2 TNC	2.41e-04	7	119	2	37174615
Pubmed	Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.	RGMB RIMS1	2.41e-04	7	119	2	24236485
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	NOP53 ZC3H13 SIPA1L3 YTHDC1 FAT1 HTATSF1 WDR24	2.54e-04	361	119	7	26167880
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SIPA1L3 FNBP4 VARS2 WRAP53 NSUN2 SHC3 TAF3 AP2A2 FARP1 SMARCC2 PARD3 MTDH LRRFIP1 LRRFIP2	2.55e-04	1371	119	14	36244648
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	HSPG2 HECTD4 PSMD12 DST AP2A2 EPN1 HECTD1 TAPBP	2.59e-04	481	119	8	28190767
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	HSPG2 TNC ZMYND8 HECTD4 DST FARP1 DCAF4	2.62e-04	363	119	7	14691545
Pubmed	A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.	AMBRA1 DCAF8L1 DCAF4	2.79e-04	37	119	3	16949367
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PPAN NOP53 MYO18A TACC2 NSUN2 HECTD1 MTDH LRRFIP1 LRRFIP2 WDR24	2.90e-04	759	119	10	35915203
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	ARHGEF18 ARHGEF11 ARHGEF3	3.02e-04	38	119	3	11756498
Pubmed	Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis.	TNC ACAN	3.21e-04	8	119	2	17336282
Pubmed	Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.	ARHGEF18 PARD3	3.21e-04	8	119	2	22006950
Pubmed	Mice develop normally without tenascin.	HSPG2 TNC	3.21e-04	8	119	2	1383086
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	3.21e-04	8	119	2	10810084
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	SIN3B MXD4	3.21e-04	8	119	2	8617250
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	PPAN ZC3H13 TACC2 YTHDC1 PABIR2 PKN1 EPB41L1 LRRFIP1	3.50e-04	503	119	8	16964243
Pubmed	Human transcription factor protein interaction networks.	HSPG2 SIN3B PPAN NOP53 ZMYND8 MYO18A PSMD12 RREB1 BCOR NSUN2 FAT1 TAF3 DST SMARCC2	3.87e-04	1429	119	14	35140242
Pubmed	Identification and characterization of novel substrates of Trk receptors in developing neurons.	SH2B2 PLCG1	4.11e-04	9	119	2	9856458
Pubmed	Accessory protein recruitment motifs in clathrin-mediated endocytosis.	AP2A2 EPN1	4.11e-04	9	119	2	12057195
Pubmed	Perlecan is essential for cartilage and cephalic development.	HSPG2 ACAN	4.11e-04	9	119	2	10545953
Pubmed	Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.	HK1 HK3	4.11e-04	9	119	2	19554504
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN2 CLCN6	4.11e-04	9	119	2	23115349
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	HK1 HK3	4.11e-04	9	119	2	21074528
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SYNE1 PPFIA2 ARHGEF18 AP2A2 RIMS1 EPB41L1	4.27e-04	281	119	6	28706196
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	NOP53 SYNE1 MYO18A YTHDC1 NSUN2 SHC3 SENP1 DST AP2A2 LRRFIP1 LRRFIP2	4.27e-04	949	119	11	36574265
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	ARHGEF18 ARHGEF11 ARHGEF3	4.36e-04	43	119	3	12376548
Cytoband	7q22	ACHE MUC12 SH2B2 RASA4	2.96e-06	38	119	4	7q22
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	ACHE MUC12 SH2B2 RASA4 RASA4B	2.77e-04	219	119	5	chr7q22
GeneFamily	Cadherin related	DCHS2 FAT1 CDHR4	5.42e-05	17	80	3	24
GeneFamily	CD molecules\|Mucins	MUC19 MUC16 MUC12	1.05e-04	21	80	3	648
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF18 ARHGEF11 FARP1 ARHGEF3	2.08e-04	66	80	4	722
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PSD3 ARHGEF18 SH2B2 FARP1 RASA4B PLCG1	3.03e-04	206	80	6	682
GeneFamily	PDZ domain containing	SIPA1L3 MYO18A ARHGEF11 RIMS1 PARD3	5.69e-04	152	80	5	1220
GeneFamily	Chloride voltage-gated channels	CLCN2 CLCN6	8.50e-04	10	80	2	302
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	8.50e-04	10	80	2	830
GeneFamily	WD repeat domain containing	DCAF8L2 AMBRA1 WRAP53 DCAF8L1 DCAF4 WDR24	1.07e-03	262	80	6	362
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	AMBRA1 DCAF4	2.83e-03	18	80	2	498
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH FRAS1 ARHGEF28 NEBL SIPA1L3 TACC2 FAT1 FARP1 PARD3 EPB41L1	1.18e-10	193	119	10	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ARHGEF28 NEBL SIPA1L3 FAT1 FARP1 PARD3 EPB41L1	5.39e-08	194	119	8	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ARHGEF28 NEBL FAT1 FARP1 PARD3 EPB41L1 PLXNB1	5.39e-08	194	119	8	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	STARD13 NEBL RNF43 FAT1 FARP1 PTCH2 RIMS1	8.95e-07	193	119	7	e2b455387d1de7812305200a2041a0f4759a6f54
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH FRAS1 ARHGEF28 NEBL FAT1 FARP1 EPB41L1	9.27e-07	194	119	7	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ARHGEF28 NEBL SIPA1L3 FARP1 PARD3 EPB41L1	9.59e-07	195	119	7	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ARHGEF28 NEBL SIPA1L3 TACC2 FAT1 EPB41L1	9.92e-07	196	119	7	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ARHGEF28 NEBL SIPA1L3 FAT1 FARP1 EPB41L1	9.92e-07	196	119	7	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARHGEF28 NEBL TNC DST HECTD1 EPB41L1 PLXNB1	1.14e-06	200	119	7	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGEF28 NEBL MUC16 DST HECTD1 EPB41L1 PLXNB1	1.14e-06	200	119	7	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 EFCAB6 PPFIA2 ARHGEF18 DNAJC6 RASA4	4.42e-06	159	119	6	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 EFCAB6 PPFIA2 ARHGEF18 DNAJC6 RASA4	4.42e-06	159	119	6	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	3'-Adult-LargeIntestine-Epithelial-mature_enterocytic-Paneth\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF212 MYO18A AMBRA1 ARHGEF11 RIMS1 IGKV3-11	5.67e-06	166	119	6	b64ab3d13b76bba3c305ebbfc96f983cd6ca30c9
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 EFCAB6 PPFIA2 ARHGEF18 DNAJC6 RASA4	5.67e-06	166	119	6	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 EFCAB6 PPFIA2 ARHGEF18 DNAJC6 RASA4	5.67e-06	166	119	6	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	TNC BACH2 PSD3 DST ARHGEF3 PARD3	1.02e-05	184	119	6	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNH8 FAT1 CLCN2 GADL1 PARD3 PLXNB1	1.08e-05	186	119	6	e52cf44989c57c433bf82e9fa13b4643e88f3577
ToppCell	droplet-Lung-LUNG-1m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNH8 FAT1 CLCN2 GADL1 PARD3 PLXNB1	1.08e-05	186	119	6	4c0b59d845b79323e7a3287e7c4d249f5f322556
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 SIPA1L3 ZMYND8 HECTD4 RNF43 FARP1	1.08e-05	186	119	6	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 SIPA1L3 ZMYND8 HECTD4 RNF43 FARP1	1.08e-05	186	119	6	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ZC3H13 PMS2CL RNF43 ZNF469 FARP1 PLCG1	1.15e-05	188	119	6	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL SYNE1 SIPA1L3 FARP1 PARD3 EPB41L1	1.15e-05	188	119	6	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	BAL-Severe-Myeloid-TRAM\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARHGEF28 VSIG4 ENPP4 DST ECSCR EPB41L1	1.26e-05	191	119	6	4c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCell	BAL-Severe-Myeloid-TRAM\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF28 VSIG4 ENPP4 DST ECSCR EPB41L1	1.26e-05	191	119	6	de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCell	CTRL-Myeloid-Alveolar_Macrophage\|Myeloid / Disease state, Lineage and Cell class	ARHGEF28 VSIG4 PSD3 DST ARHGEF3 EPB41L1	1.34e-05	193	119	6	80871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH FRAS1 ARHGEF28 NEBL FARP1 EPB41L1	1.34e-05	193	119	6	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NEBL RNF43 FAT1 FARP1 PTCH2 RIMS1	1.38e-05	194	119	6	fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFCAB6 SYNE1 MUC16 CEP126 CDHR4 CCDC40	1.38e-05	194	119	6	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NEBL FAT1 FARP1 PTCH2 RIMS1 LRRFIP2	1.42e-05	195	119	6	c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ARHGEF28 NEBL SIPA1L3 FARP1 EPB41L1	1.46e-05	196	119	6	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 NEBL FAT1 FARP1 PARD3 EPB41L1	1.50e-05	197	119	6	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGEF28 NEBL PSD3 MUC16 TACC2 EPB41L1	1.55e-05	198	119	6	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KCNH8 RNF43 ZNF469 ACAN DMRTA1	2.92e-05	133	119	5	63d2f096ae47d9b587acc6c5fbd346e5e58842b8
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	STARD13 DMGDH SPRY2 ZNF212 RASA4B	3.02e-05	134	119	5	9e12aac8f42790c2f104dfd61c87aa99fc7925f1
ToppCell	NS-critical-d_07-13-Epithelial-unknown_epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SIN3B HECTD4 MUC16 RIMS1 PLXNB1	3.86e-05	141	119	5	33ad925ff7be3c682741a6328216a89f9d4033e9
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_pDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	KCNH8 ENPP4 EPB41L1 PLXNB1 CDHR4	8.61e-05	167	119	5	8ddf9da71a7c4ed53588435db826563a24cee616
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STARD13 KCNH8 BACH2 DNAJC6 DST	8.86e-05	168	119	5	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	Control\|World / group, cell type (main and fine annotations)	ARHGEF28 NEBL SYNE1 TACC2 PARD3	8.86e-05	168	119	5	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRAS1 ARHGEF28 FAT1 FARP1 EPB41L1	8.86e-05	168	119	5	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NEBL SHC3 ACAN FARP1 PARD3	9.37e-05	170	119	5	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	NEBL TACC2 DST FARP1 PARD3	9.37e-05	170	119	5	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 DCHS2 PPFIA2 HECTD4 PSD3	9.37e-05	170	119	5	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KCNH8 ZNF469 ACAN DMRTA1	9.97e-05	90	119	4	a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KCNH8 ZNF469 ACAN DMRTA1	9.97e-05	90	119	4	ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	DCHS2 FRAS1 ARHGEF28 MUC16 RIMS1	1.04e-04	174	119	5	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD13 HK1 SYNE1 BACH2 HECTD4	1.07e-04	175	119	5	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	AMBRA1 RREB1 NSUN2 RNF43 DST	1.07e-04	175	119	5	334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KCNH8 PSD3 ARHGEF11 NSUN2 CLCN6	1.07e-04	175	119	5	69ed3c7c45df6bef70f5f2ff003531160bf3b32b
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD13 HK1 SYNE1 BACH2 HECTD4	1.07e-04	175	119	5	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	AMBRA1 RREB1 NSUN2 DST GDF11	1.07e-04	175	119	5	da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	SYNE1 MYO18A TAF3 DST HTATSF1	1.13e-04	177	119	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DCHS2 ARHGEF28 FAT1 FARP1 PARD3	1.16e-04	178	119	5	544379f5a6145429762258d426b876bb36c112f5
ToppCell	C_00\|World / shred on cell type and cluster	RGMB ZBTB38 FNBP4 RNF43 PTCH2	1.19e-04	179	119	5	da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 NEBL SHC3 FARP1 PARD3	1.19e-04	179	119	5	cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DCHS2 TNC SYNE1 CRTAC1 DST	1.19e-04	179	119	5	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRG1 HSPG2 ZBTB38 PPFIA2 ECSCR	1.26e-04	181	119	5	4df7972f88117108698efd06b124b232f8588981
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRG1 HSPG2 ZBTB38 PPFIA2 ECSCR	1.26e-04	181	119	5	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NEBL CRTAC1 TACC2 RNF43 PARD3	1.32e-04	183	119	5	6847c1252d6bb105524f812658112517fd351eab
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	KCNH8 ARHGEF28 MUC16 STS EPB41L1	1.32e-04	183	119	5	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	NEBL SYNE1 CRTAC1 TACC2 PARD3	1.32e-04	183	119	5	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE DNAJC6 SHC3 EPB41L1 PLXNB1	1.32e-04	183	119	5	0f02136359787bd78146617990968baa47a65d86
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 CRTAC1 RASA4 ECSCR RASA4B	1.32e-04	183	119	5	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE DNAJC6 SHC3 EPB41L1 PLXNB1	1.32e-04	183	119	5	2f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	NEBL PSD3 TACC2 DST LRRFIP2	1.36e-04	184	119	5	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NEBL SHC3 FAT1 FARP1 PARD3	1.39e-04	185	119	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	NEBL SIPA1L3 DST STS FARP1	1.39e-04	185	119	5	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	COPD-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	NEBL MUC16 FAT1 RIMS1 PARD3	1.43e-04	186	119	5	d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCell	mild-unassigned\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZNF212 TMEM79 RNF43 AP2A2 WDR24	1.43e-04	186	119	5	5b2e1a58916f392fa1156bf9210df528775248ff
ToppCell	Control-Epithelial-ATII\|World / Disease state, Lineage and Cell class	NEBL CRTAC1 TACC2 SHC3 PARD3	1.43e-04	186	119	5	f4b6e401e19a71beddc73d8a1e08359f7c4025cf
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FRAS1 ARHGEF28 SIPA1L3 RNF43 FARP1	1.46e-04	187	119	5	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CUX2 ARHGEF28 ZC3H13 RNF43 FARP1	1.46e-04	187	119	5	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	ARHGEF28 TNC PPFIA2 RIMS1 LRRFIP1	1.50e-04	188	119	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	NEBL TNC CRTAC1 TACC2 PARD3	1.50e-04	188	119	5	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	NEBL SYNE1 BACH2 TACC2 PARD3	1.50e-04	188	119	5	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STARD13 TNC PPFIA2 FAT1 EPB41L1	1.54e-04	189	119	5	1ff4f8da572bdc6356e9df9f41a7f62c81d4c570
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Control / Disease state, Lineage and Cell class	ARHGEF28 VSIG4 PSD3 DST EPB41L1	1.54e-04	189	119	5	937e876122bc4b94372a4104e9c1a9068c232018
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL SYNE1 ZMYND8 AMBRA1 FARP1	1.54e-04	189	119	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 CUX2 TNC PSD3 SHC3	1.58e-04	190	119	5	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRG1 KCNH8 SLC31A2 TNC FAT1	1.58e-04	190	119	5	050d6e0546954675b6adbfecb67854b1e09739d1
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	ARHGEF28 VSIG4 ENPP4 DST EPB41L1	1.58e-04	190	119	5	2592765016f291565697265800a232b2edef3792
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 CUX2 TNC PSD3 SHC3	1.58e-04	190	119	5	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 CRTAC1 RASA4 ECSCR RASA4B	1.58e-04	190	119	5	141266bf411ea675fbf889b20c1b08673c45ff95
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	NEBL PSD3 TACC2 DST LRRFIP2	1.58e-04	190	119	5	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	NEBL PSD3 TACC2 DST LRRFIP2	1.62e-04	191	119	5	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NEBL CRTAC1 TACC2 SHC3 PARD3	1.62e-04	191	119	5	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARHGEF28 VSIG4 ENPP4 DST EPB41L1	1.62e-04	191	119	5	2b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGEF28 VSIG4 ENPP4 DST EPB41L1	1.62e-04	191	119	5	02e1ae144da7274171e055356d10e8d175c5347f
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	NEBL TACC2 FAT1 RIMS1 PARD3	1.62e-04	191	119	5	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	Severe_COVID-19-Myeloid-TRAM3\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ARHGEF28 VSIG4 ENPP4 DST EPB41L1	1.62e-04	191	119	5	05867b96199a46a415848409130697c810d18937
ToppCell	Basal_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	TNC RNF43 FAT1 IGKV3-11 PLXNB1	1.62e-04	191	119	5	a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NEBL TACC2 SHC3 FARP1 PARD3	1.62e-04	191	119	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	NEBL SYNE1 CRTAC1 TACC2 PARD3	1.65e-04	192	119	5	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	NEBL TACC2 SHC3 FARP1 PARD3	1.65e-04	192	119	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF28 VSIG4 ENPP4 DST EPB41L1	1.65e-04	192	119	5	34505a13b8a47c9286c560122fa7861b9c331a08
ToppCell	COVID-19-Myeloid-TRAM1\|COVID-19 / Condition, Lineage and Cell class	ARHGEF28 VSIG4 DST ECSCR EPB41L1	1.65e-04	192	119	5	52b8578699325b0d35a2d3ba36772096130ccc0c
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF28 VSIG4 ENPP4 DST EPB41L1	1.65e-04	192	119	5	57c1410ebf90c230993e065eb78385daa3360960
ToppCell	COPD-Epithelial-Goblet\|COPD / Disease state, Lineage and Cell class	NEBL MUC16 FAT1 RIMS1 PARD3	1.65e-04	192	119	5	93b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRRG1 PPFIA2 ENPP4 DNAJC6 DST	1.65e-04	192	119	5	3ce5dbde41aeb73d49f2c7991d34682f0827fa5a
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SYNE1 CRTAC1 TACC2 SHC3 PARD3	1.70e-04	193	119	5	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 SYNE1 CEP126 CDHR4 CCDC40	1.70e-04	193	119	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; PC3; HG-U133A	HSPG2 SIPA1L3 PSD3 GMIP MXD4 ACAN PARD3 CCDC40	5.57e-06	195	112	8	1911_UP
Drug	Bicuculline (+) [485-49-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A	HSPG2 ENPP4 SIRT6 EHBP1L1 CLCN2 AP2A2 IKBKE PARD3	6.01e-06	197	112	8	2796_DN
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A	STARD13 RNF43 EHBP1L1 AP2A2 SMARCC2 PLCG1 GDF11 PLXNB1	6.01e-06	197	112	8	3877_DN
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	NEBL SIPA1L3 WRAP53 RNF43 CLCN6 RIMS1 PLCG1 LRRFIP1	6.23e-06	198	112	8	5545_DN
Drug	MUAC	PPAN ACHE STS DMRTA1	1.20e-05	29	112	4	CID000000366
Drug	IAA-inositol	HK1 ACHE	2.40e-05	2	112	2	CID000152656
Drug	pioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A	ZBTB38 ARHGEF28 TNC SYNE1 PSD3 IKBKE HTATSF1	3.44e-05	183	112	7	7088_DN
Drug	Fluticasone propionate [80474-14-2]; Up 200; 8uM; MCF7; HT_HG-U133A	HSPG2 ARHGEF28 SZT2 TNC SIPA1L3 STS CLCN6	4.67e-05	192	112	7	4129_UP
Drug	Nystatine [1400-61-9]; Up 200; 4.4uM; HL60; HT_HG-U133A	STARD13 NEBL TNC ZC3H13 MXD4 STS DCAF4	5.15e-05	195	112	7	2500_UP
Drug	Beta-sistosterol [83-46-5]; Down 200; 9.6uM; PC3; HT_HG-U133A	HSPG2 NEBL PCDHGA10 TNC SYNE1 ZMYND8 MXD4	5.15e-05	195	112	7	4073_DN
Drug	PHA-00816795 [212631-79-3]; Up 200; 10uM; PC3; HT_HG-U133A	TNC ZMYND8 PSD3 SIRT6 RNF43 MXD4 PLCG1	5.15e-05	195	112	7	7072_UP
Drug	Methotrimeprazine maleat salt [7104-38-3]; Down 200; 9uM; MCF7; HT_HG-U133A	NEBL SIPA1L3 MXD4 STS CLCN6 IKBKE PARD3	5.32e-05	196	112	7	4723_DN
Drug	(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; MCF7; HT_HG-U133A	HBS1L ARHGEF28 VSIG4 PSD3 AMBRA1 STS FARP1	5.32e-05	196	112	7	5533_UP
Drug	Brinzolamide [138890-62-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	FRAS1 SZT2 ZC3H13 PSD3 MXD4 IKBKE PARD3	5.49e-05	197	112	7	5016_UP
Drug	Carbinoxamine maleate salt [3505-38-2]; Down 200; 9.8uM; PC3; HT_HG-U133A	STARD13 SLC31A2 HECTD4 TACC2 ARHGEF11 DCAF4 EPB41L1	5.49e-05	197	112	7	7138_DN
Drug	Meclocycline sulfosalicylate [73816-42-9]; Down 200; 5.8uM; MCF7; HT_HG-U133A	SPRY2 SIPA1L3 ENPP4 MXD4 CLCN6 AP2A2 IKBKE	5.49e-05	197	112	7	3277_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A	STARD13 SPRY2 HBS1L PSD3 MXD4 EHBP1L1 IKBKE	5.67e-05	198	112	7	5219_DN
Drug	Evoxine [522-11-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	SPRY2 SIPA1L3 PSD3 ARHGEF11 MXD4 CLCN6 IKBKE	5.67e-05	198	112	7	4704_DN
Drug	Bupivacaine hydrochloride [18010-40-7]; Down 200; 12.4uM; MCF7; HT_HG-U133A	PRRG1 NEBL ARHGEF11 MXD4 STS PKN1 PLCG1	5.67e-05	198	112	7	5537_DN
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A	STARD13 SZT2 ZC3H13 SIPA1L3 MXD4 EHBP1L1 PARD3	5.67e-05	198	112	7	6053_DN
Drug	U-62066 [87151-85-7]; Down 200; 1uM; MCF7; HT_HG-U133A	HSPG2 MXD4 EHBP1L1 CLCN2 AP2A2 PARD3 CCDC40	5.67e-05	198	112	7	3901_DN
Drug	Aztreonam [78110-38-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A	HBS1L NEBL AMBRA1 WRAP53 ARHGEF11 RNF43 EPB41L1	5.85e-05	199	112	7	5535_DN
Drug	Dimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; MCF7; HT_HG-U133A	ZMYND8 PSD3 ENPP4 WRAP53 AP2A2 IKBKE PLCG1	5.85e-05	199	112	7	2807_DN
Drug	2-Chloropyrazine [14508-49-7]; Down 200; 35uM; PC3; HT_HG-U133A	ARHGEF28 NEBL SIRT6 ARHGEF11 CLCN2 AP2A2 PLCG1	6.04e-05	200	112	7	5750_DN
Disease	mean corpuscular hemoglobin concentration	HBS1L CUX2 HK1 SLC31A2 BACH2 HECTD4 PSD3 RREB1 RNF43 EHBP1L1 CLCN6 DMRTA1 MTDH CCDC40	7.03e-05	1105	111	14	EFO_0004528
Disease	Macrostomia	FRAS1 PTCH2	8.37e-05	4	111	2	C0024433
Disease	tapasin measurement	ARHGEF3 TAPBP	8.37e-05	4	111	2	EFO_0802118
Disease	glucose measurement	SPRY2 CUX2 ZBTB38 PSD3 RREB1 DMRTA1 PLCG1 CDHR4	9.79e-05	380	111	8	EFO_0004468
Disease	FEV/FEC ratio	STARD13 HSPG2 SPRY2 DCHS2 FRAS1 ARHGEF28 NEBL BACH2 ARHGEF18 RREB1 DST ACAN PARD3 CDHR4	2.12e-04	1228	111	14	EFO_0004713
Disease	chronic obstructive pulmonary disease	DCHS2 FRAS1 ZBTB38 ARHGEF28 NEBL BACH2 TSPY26P VARS2 RREB1 DCAF4	2.77e-04	688	111	10	EFO_0000341
Disease	Alzheimer disease, age at onset	HSPG2 DCHS2 SZT2 FAT1 DST FARP1 PARD3	3.26e-04	343	111	7	EFO_0004847, MONDO_0004975
Disease	hemoglobin measurement, mean corpuscular hemoglobin concentration	HBS1L TMEM79	3.87e-04	8	111	2	EFO_0004509, EFO_0004528
Disease	lymphocyte count	HBS1L FRAS1 ZBTB38 PCDHGA10 BACH2 HECTD4 PSD3 ARHGEF18 VARS2 RREB1 ARHGEF11 ZNF469 IKBKE DMRTA1 ARHGEF3	3.89e-04	1464	111	15	EFO_0004587
Disease	basophil count	HBS1L CUX2 BACH2 ARHGEF18 GMIP RREB1 ZNF469 DMRTA1	4.93e-04	483	111	8	EFO_0005090
Disease	non-melanoma skin carcinoma	BACH2 ZNF469 TAF3 FARP1 PARD3 EPB41L1	5.11e-04	265	111	6	EFO_0009260
Disease	spleen volume	HBS1L HECTD4 DMRTA1	5.73e-04	43	111	3	EFO_0600047
Disease	reticulocyte count	HBS1L HK1 ARHGEF28 SLC31A2 HECTD4 RREB1 ZNF469 FAT1 SENP1 DMRTA1 ARHGEF3 DCAF4	5.76e-04	1045	111	12	EFO_0007986
Disease	Kunitz-type protease inhibitor 2 measurement	SIPA1L3 ARHGEF3	6.19e-04	10	111	2	EFO_0008200
Disease	cleft lip	SPRY2 ARHGEF28 SYNE1 MUC16 DST DMRTA1	7.34e-04	284	111	6	EFO_0003959
Disease	Tremor	ZNF142 ACHE	7.54e-04	11	111	2	C0040822
Disease	developmental disorder of mental health (implicated_via_orthology)	SIN3B PARD3 PLXNB1	8.42e-04	49	111	3	DOID:0060037 (implicated_via_orthology)
Disease	reaction time measurement	CUX2 KCNH7 BACH2 HECTD4 MUC19 AMBRA1 TACC2 FARP1 RIMS1	8.67e-04	658	111	9	EFO_0008393
Disease	gout	CUX2 PSD3 RREB1 FAT1 DST	8.91e-04	196	111	5	EFO_0004274
Disease	stomach carcinoma (is_implicated_in)	BCOR RNF43	9.03e-04	12	111	2	DOID:5517 (is_implicated_in)
Disease	alcohol consumption measurement, alcohol drinking	CUX2 HECTD4	9.03e-04	12	111	2	EFO_0004329, EFO_0007878
Disease	platelet crit	STARD13 HBS1L HK1 BACH2 RREB1 ARHGEF11 SENP1 DMRTA1 ARHGEF3 WDR24 CCDC40	9.36e-04	952	111	11	EFO_0007985
Disease	metabolic syndrome	CUX2 HECTD4 PSD3 CRTAC1 DMRTA1	9.75e-04	200	111	5	EFO_0000195
Disease	HbA1c measurement	HBS1L CUX2 ZBTB38 HK1 TMEM79 RREB1 SHC3 SENP1 DMRTA1	1.04e-03	675	111	9	EFO_0004541
Disease	MAP kinase-activated protein kinase 3 measurement	ZC3H13 ARHGEF3	1.06e-03	13	111	2	EFO_0008226
Disease	colorectal cancer (is_implicated_in)	WRAP53 BCOR RNF43 FAT1	1.15e-03	121	111	4	DOID:9256 (is_implicated_in)
Disease	infant head circumference	ZBTB38 PLCG1	1.43e-03	15	111	2	EFO_0004577
Disease	severe acute respiratory syndrome, COVID-19	ARHGEF28 ZNF212 DCAF8L2 PSD3 ARHGEF18 ARHGEF3 PARD3	1.54e-03	447	111	7	EFO_0000694, MONDO_0100096
Disease	Intellectual Disability	CUX2 ZNF142 HK1 SYNE1 NSUN2 SMARCC2 EPB41L1	1.54e-03	447	111	7	C3714756
Disease	hearing threshold measurement, hearing measurement	SLC31A2 MYO18A TAF3	1.59e-03	61	111	3	EFO_0007616, EFO_0007618
Disease	Global developmental delay	ZNF142 HK1 SZT2 SMARCC2	1.63e-03	133	111	4	C0557874
Disease	Alzheimer disease, polygenic risk score	FRAS1 FNBP4 PSD3 MUC19 TACC2 DST RIMS1 DCAF4	1.70e-03	586	111	8	EFO_0030082, MONDO_0004975
Disease	C-reactive protein measurement	DMGDH DCHS2 CUX2 ARHGEF28 TMEM79 PSD3 CRTAC1 RREB1 DNAJC6 ZNF469 SMARCC2 DCAF4	1.96e-03	1206	111	12	EFO_0004458
Disease	reticulocyte measurement	HBS1L HK1 ARHGEF28 SLC31A2 HECTD4 RREB1 ZNF469 FAT1 SENP1 DMRTA1 ARHGEF3	2.08e-03	1053	111	11	EFO_0010700
Disease	diabetes mellitus	SPRY2 RREB1 DMRTA1	2.17e-03	68	111	3	EFO_0000400
Disease	hair colour measurement	RGMB HBS1L FRAS1 CUX2 ZBTB38 ZNF469 PARD3 EPB41L1	2.30e-03	615	111	8	EFO_0007822
Disease	serum gamma-glutamyl transferase measurement	DMGDH CUX2 SIPA1L3 HECTD4 PSD3 RREB1 ARHGEF11 PLCG1 PARD3 DCAF4	2.39e-03	914	111	10	EFO_0004532
Disease	atopic eczema	SPRY2 DCHS2 ZBTB38 BACH2 DMRTA1	2.68e-03	252	111	5	EFO_0000274
Disease	testosterone measurement	STARD13 DCHS2 CUX2 ACHE FNBP4 PSD3 CRTAC1 VARS2 RREB1 WRAP53 GADL1 PLCG1	3.09e-03	1275	111	12	EFO_0004908
Disease	infant body height	ZBTB38 ACAN	3.37e-03	23	111	2	EFO_0006785
Disease	Moderate albuminuria	TSPY26P VARS2 EHBP1L1	3.45e-03	80	111	3	HP_0012594
Disease	cancer (implicated_via_orthology)	SIN3B CUX2 PSMD12 DST SMARCC2	3.49e-03	268	111	5	DOID:162 (implicated_via_orthology)
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	STARD13 CUX2 BACH2	3.57e-03	81	111	3	EFO_0803334
Disease	Sjogren's syndrome (is_marker_for)	MUC19 MUC16	3.67e-03	24	111	2	DOID:12894 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FGGDPTSVTLFGESA	ACHE	221	P22303
ADIPSVAFSSRLGGS	DCAF4	461	Q8WV16
TSGRRLEGTDPGTFS	BACH2	791	Q9BYV9
GEEPGRDSLFSSLAG	ARHGEF18	56	Q6ZSZ5
LDSEGSFLNPTTGSR	ARHGEF3	461	Q9NR81
SGLDSGTERFPSLSE	ARHGEF11	221	O15085
ATEGRGFPASGLATE	AMBRA1	466	Q9C0C7
GLISTGSDSESPATR	CUX2	1136	O14529
TSTLGGLGFSSERNP	BCOR	106	Q6W2J9
TSGGPTTFAVDRLSG	CDHR4	481	A6H8M9
PSSGGSGLLVDVFSD	AP2A2	676	O94973
RELSGGAEAGTVPTS	RASA4	746	O43374
GAPDVATLTGGRFSS	HSPG2	4336	P98160
RELSGGAEAGTVPTS	RASA4B	746	C9J798
ESDVGFIPTSGLSGE	HBS1L	436	Q9Y450
LESPSFTGTGDTEIA	NSUN2	471	Q08J23
SSRTGIPSGDELDSF	ARHGEF28	506	Q8N1W1
SRTSGVLSTTGTPFD	FAT1	2026	Q14517
SPSGEETAGSVLTLS	MUC16	796	Q8WXI7
ASSLTPGLRESSGSE	MUC16	7826	Q8WXI7
SRTESGPGDATLSTI	MUC16	10306	Q8WXI7
DGSASVGREFIATTP	EPB41L1	731	Q9H4G0
SDADSGFLGLRPTSV	NOP53	16	Q9NZM5
TGTGDRFGPETASDL	FRAS1	1886	Q86XX4
FGPGELDSVGSSSDA	MXD4	166	Q14582
VGGGSESRSLDSPTS	GMIP	426	Q9P107
PFDLLIFGSGSDETT	KCNH7	506	Q9NS40
SISGGGTEISQFTPE	DST	3041	Q03001
STPRSLAGLTSGVFE	KIAA2026	231	Q5HYC2
SLGTERFSSVAGTPE	IKBKE	471	Q14164
GSTDGLPDLGTESLF	DCAF8L2	6	P0C7V8
SGVPDRFSGSIDSSS	IGLV6-57	76	P01721
TGGDAPAFSTSTLLS	PLXNB1	856	O43157
SGGSVSIDLGDTSFR	MUC19	296	Q7Z5P9
RSETTGPLFGLTGTF	MUC19	2426	Q7Z5P9
SETTRPLDIGSGTTG	MUC19	2536	Q7Z5P9
GTTRPLAGESGTTES	MUC19	2686	Q7Z5P9
RTTGSEAPEGTSGEF	MUC19	6291	Q7Z5P9
EAPEGTSGEFSGTTI	MUC19	6296	Q7Z5P9
RTTRSEAPGGTSGEF	MUC19	6651	Q7Z5P9
EAPGEATTLTGDRSS	MUC19	6746	Q7Z5P9
APAAETTTSLEGGGT	MUC19	7426	Q7Z5P9
LTASDGGDPLRSGTV	PCDHGA10	216	Q9Y5H3
STSFRQGPEESGLGD	MYO18A	726	Q92614
GLITGFRSDSSSSLP	ENPP4	11	Q9Y6X5
SRDSGVPGLEADTTG	EHBP1L1	781	Q8N3D4
SRSSGVPGLESEVAG	EHBP1L1	826	Q8N3D4
PDFTSLDVLTFAGSG	DPP3	371	Q9NY33
GSLESPATDVFGSTE	PSMD12	331	O00232
TSVTFLADPSAGGGL	HECTD4	1961	Q9Y4D8
PDSDVRFLLSESGSG	HK1	436	P19367
SFSDDGALGPVLTTF	HK3	276	P52790
RGSGDTSSLIDPDTS	LRRFIP2	326	Q9Y608
GLPSGEVLETSASGV	ACAN	956	P16112
GFPDTSGETSGVTEL	ACAN	1741	P16112
TSQPFGITDLSGETS	ACAN	1776	P16112
GLPSGIAEVSGESSR	ACAN	1896	P16112
GESSRAEIGSSLPSG	ACAN	1906	P16112
SATPTASGDRTEISG	ACAN	2186	P16112
VGLDTSVASPSSGGE	MEIS3P2	221	A8K0S8
EPDTSYGGTLRRSSS	PABIR2	11	Q7Z309
VRDGGFPSLSSTTTI	DCHS2	1801	Q6V1P9
GTLSDTATGAGSEVP	RIMS1	191	Q86UR5
GSVEEGPLSTGSSFI	HTATSF1	731	O43719
GPLSTGSSFILSSDD	HTATSF1	736	O43719
APIGGTLFSLEEGSS	CLCN6	256	P51797
PEGGSDSSESRSEFL	HECTD1	711	Q9ULT8
GSSVPDVSEGTRSAL	EFCAB6	1261	Q5THR3
QSTSLTFGEGAESPG	FARP1	391	Q9Y4F1
PGTRSAVGELGTESS	CEP126	6	Q9P2H0
DGDSAGSDSFPVGRT	SLC31A2	71	O15432
TSGPAVGRLTGSTEE	CCDC40	176	Q4G0X9
SGGEESPRSLSSSDL	DMRTA1	286	Q5VZB9
VPSSGRDGGTSRDTF	ECSCR	76	Q19T08
AFDPSGTDLAVTSLG	GDF11	261	O95390
LDPFADLGTLGSSSF	DNAJC6	676	O75061
FGIDTILSSASSGSP	BARHL2	11	Q9NY43
QSPGEFLLITGSGSE	DMGDH	586	Q9UI17
SDRSIFSGIGSTAEP	MTDH	341	Q86UE4
RTALPTSGSSAGELE	EPN1	411	Q9Y6I3
GSGTDFTLTISSLEP	IGKV3-11	86	P04433
GSTGGLPDLVTESLF	DCAF8L1	6	A6NGE4
RGVSVGPILSSSASD	CRTAC1	241	Q9NQ79
ATSGTTVLGAFDPLD	GADL1	271	Q6ZQY3
ESGSTLDLSGSRETP	ZMYND8	1116	Q9ULU4
LGTPSVLDSDSGVEF	KRBA2	316	Q6ZNG9
SSEDTAPFLGTLAGA	LRRFIP1	351	Q32MZ4
SETLPAGFRLTTTSG	PPFIA2	1216	O75334
TGTQSPEIFGSELGT	PARD3	96	Q8TEW0
SGSESEGDIFTSPKR	TAF3	411	Q5VWG9
DSLTARTPSEGEAGT	VARS2	1011	Q5ST30
GDSAFTSLSVGLPET	SZT2	1096	Q5T011
GPDLSDSLSSGGVVT	STK11IP	356	Q8N1F8
TDDLPAAFVDGTTSG	RGMB	236	Q6NW40
FEGNSVSEGRTTPSD	STARD13	536	Q9Y3M8
LDPTGQFLVSGSTSG	WRAP53	421	Q9BUR4
DELDTSGSVSPTSGR	SYNE1	8676	Q8NF91
LEEGDGSVSGSSPRS	FNBP4	421	Q8N3X1
DDLLPSGVSDRFSGS	IGLV1-36	71	A0A0B4J1U3
LGSELFSPGGSTRDL	PTCH2	631	Q9Y6C5
ITEGDSFSQSLGPSR	RNF43	316	Q68DV7
RSISFASGGDPDTTD	SHC3	251	Q92529
PSSDSFLGSGDLRTF	SENP1	76	Q9P0U3
VFLFTASSGGLPTDE	STS	101	P08842
SLGGLDPAFTSTEDL	SIPA1L3	391	O60292
GTEGASSSPTEGFLL	SIN3B	996	O75182
ASPGSEARTTGDISV	PKN1	536	Q16512
TGAGISTASGIPDFR	SIRT6	51	Q8N6T7
PAFGLESSGIAGTTS	SMARCC2	731	Q8TAQ2
LGSSFSSGPVADGII	SPRY2	136	O43597
ESPTGSAESAGIALR	CLCN2	711	P51788
SLSPFEAASLGGSLT	RREB1	411	Q92766
VGGSDEEASGIPSRT	PPAN	356	Q9NQ55
SGPSLEDSVGLFLSA	TAPBP	406	O15533
VSGSFTTALDGPSGL	TNC	1791	P24821
SLRVGSSAGSPTAIE	TMEM79	46	Q9BSE2
GEAAESSPSFLLGSE	TLE7	96	A0A1W2PR48
TGAPDGSFLVRESET	PLCG1	576	P19174
SSSLEIPDDFGGRSE	TTC14	581	Q96N46
ETFLQTLESPGGSGS	SH2B2	376	O14492
SGDLPEAGTTRTFSV	TACC2	1721	O95359
GSDPVTIFLRDSSGD	VSIG4	61	Q9Y279
GISPIVFDRSGSSAS	YTHDC1	306	Q96MU7
GLGRTTAPSSTASDF	ZNF469	2376	Q96JG9
DEVFDSSGLSPGFLG	PRRG1	136	O14668
GSSVLLETGPGDSTL	ZNF212	256	Q9UDV6
GSTSVDSEGFSIPDT	PMS2CL	111	Q68D20
ENRIGEFSSTGSTLP	ZBTB38	431	Q8NAP3
GPELSSFEGIGTSDL	ZNF142	736	P52746
GLASSALSVFETEPG	WDR24	391	Q96S15
GRGEAASTATTPSLE	TSPY26P	56	Q9H489
ALGEPGLSFTTTDLS	TCFL5	31	Q9UL49
SFDGVSLDSSGPEDR	UHRF1BP1	1106	Q6BDS2
SGTFSPVRLDESGED	PSD3	376	Q9NYI0
VFERLGPSTGSTAET	ZC3H13	26	Q5T200
LPSRSEEGSFSQGTV	KCNH8	1046	Q96L42
DTALSPGSTTALSFG	MUC12	1061	Q9UKN1
DTALSPGSTTALSFG	MUC12	3701	Q9UKN1
SSTFGTGLGDDRSEI	NEBL	886	O76041