Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

6.41e-07271255GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

7.77e-07281255GO:0099602
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

VRK2 CDK12 ROR1 ADCK1 INSR PAPSS2 PTK7 CHUK MAPK14 CSNK2B GUCY2D PIP4K2A PIP4K2B PEAK1 STKLD1

3.76e-0570912515GO:0016773
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

VRK2 CDK12 ROR1 ADCK1 INSR PTDSS2 PAPSS2 PTK7 CHUK MAPK14 CSNK2B GUCY2D PIP4K2A PIP4K2B PEAK1 STKLD1 POLQ

7.69e-0593812517GO:0016772
GeneOntologyMolecularFunctionkinase activity

VRK2 CDK12 ROR1 ADCK1 INSR PAPSS2 PTK7 CHUK MAPK14 CSNK2B GUCY2D PIP4K2A PIP4K2B PEAK1 STKLD1

8.73e-0576412515GO:0016301
GeneOntologyMolecularFunction1-phosphatidylinositol-5-phosphate 4-kinase activity

PIP4K2A PIP4K2B

1.16e-0431252GO:0016309
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNH7 TMC2 TRPA1 TRPC5 OCA2 RYR2 TPCN1 SLC9C1 CLCN7 CLCA2 ATP5F1B

1.48e-0445912511GO:0005216
GeneOntologyMolecularFunctionWnt receptor activity

ROR1 LRP6 LRP5

1.53e-04171253GO:0042813
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TRPA1 RYR2 TPCN1

1.82e-04181253GO:0015278
GeneOntologyMolecularFunctionprotein kinase activity

VRK2 CDK12 ROR1 ADCK1 INSR PTK7 CHUK MAPK14 CSNK2B GUCY2D PEAK1 STKLD1

3.90e-0460012512GO:0004672
GeneOntologyMolecularFunctionchannel activity

KCNH7 TMC2 TRPA1 TRPC5 OCA2 RYR2 TPCN1 SLC9C1 CLCN7 CLCA2 ATP5F1B

4.66e-0452512511GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNH7 TMC2 TRPA1 TRPC5 OCA2 RYR2 TPCN1 SLC9C1 CLCN7 CLCA2 ATP5F1B

4.74e-0452612511GO:0022803
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPA1 RYR2 TPCN1

9.47e-04311253GO:0099604
GeneOntologyMolecularFunctioncoreceptor activity

ROR1 PTK7 LRP6 LRP5

1.08e-03721254GO:0015026
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TRPA1 RYR2 TPCN1

1.14e-03331253GO:0005217
GeneOntologyMolecularFunctionWnt-protein binding

ROR1 LRP6 LRP5

1.24e-03341253GO:0017147
GeneOntologyMolecularFunctioncalcium channel activity

TMC2 TRPA1 TRPC5 RYR2 TPCN1

1.32e-031291255GO:0005262
GeneOntologyMolecularFunction1-phosphatidylinositol-4-phosphate 5-kinase activity

PIP4K2A PIP4K2B

1.36e-0391252GO:0016308
GeneOntologyMolecularFunctionATP hydrolysis activity

DYNC2H1 MYO9B WRN SRCAP DHX35 ATP11A POLQ DNAH6 ATP5F1B

1.84e-034411259GO:0016887
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.22e-07251225GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.88e-07281225GO:1904031
GeneOntologyBiologicalProcesspositive regulation of molecular function

NPR3 MYO9B ROR1 INSR WRN EPB41L5 GMIP RYR2 CHUK MAPK14 NRXN1 TCL1A TMEM132A SPDYE2 TBC1D12 UHRF1 LRP6 LRP5 SPDYE5 SPDYE2B SPDYE6 ARAP1 WDR24 SPDYE16

2.88e-06143012224GO:0044093
GeneOntologyBiologicalProcessmesodermal cell migration

EPB41L5 LRP6 LRP5

1.65e-0591223GO:0008078
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

NPR3 MYO9B ROR1 INSR WRN GMIP MAPK14 NRXN1 TCL1A SPDYE2 TBC1D12 UHRF1 SPDYE5 SPDYE2B SPDYE6 ARAP1 WDR24 SPDYE16

3.43e-05102812218GO:0043085
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

CDK12 INSR NRXN1 SPDYE2 LRP6 LRP5 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.39e-0535812210GO:0071900
GeneOntologyBiologicalProcess1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

PIP4K2A PIP4K2B

1.04e-0431222GO:1902635
GeneOntologyBiologicalProcesspositive regulation of kinase activity

ROR1 INSR NRXN1 TCL1A SPDYE2 SPDYE5 SPDYE2B SPDYE6 WDR24 SPDYE16

1.49e-0440512210GO:0033674
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

INSR NRXN1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.52e-041931227GO:0071902
GeneOntologyBiologicalProcesscilium movement

DYNC2H1 ODAD4 NSUN7 FSIP2 SLC9C1 KATNIP CFAP70 DNAH6

1.64e-042611228GO:0003341
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

WRN USP10 SPRTN POLQ

1.85e-04481224GO:0000731
GeneOntologyBiologicalProcess1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process

PIP4K2A PIP4K2B

2.07e-0441222GO:1902633
GeneOntologyBiologicalProcesscell migration involved in gastrulation

EPB41L5 LRP6 LRP5

2.14e-04201223GO:0042074
GeneOntologyBiologicalProcessregulation of kinase activity

CDK12 ROR1 INSR NRXN1 TCL1A SPDYE2 LRP6 LRP5 SPDYE5 SPDYE2B SPDYE6 WDR24 SPDYE16

2.14e-0468612213GO:0043549
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

INSR NRXN1 TCL1A SPDYE2 SPDYE5 SPDYE2B SPDYE6 WDR24 SPDYE16

2.39e-043501229GO:0045860
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.65e-04961225GO:0000079
GeneOntologyBiologicalProcessregulation of protein kinase activity

CDK12 INSR NRXN1 TCL1A SPDYE2 LRP6 LRP5 SPDYE5 SPDYE2B SPDYE6 WDR24 SPDYE16

2.74e-0461112212GO:0045859
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.21e-041001225GO:1904029
GeneOntologyBiologicalProcessNorrin signaling pathway

LRP6 LRP5

3.43e-0451222GO:0110135
DomainSpy1

SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.58e-11111256PF11357
DomainSpeedy

SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.58e-11111256IPR020984
DomainRho_GTPase_activation_prot

MYO9B GMIP PLXNB2 RASA4 RASA4B ARAP1

2.76e-05881256IPR008936
DomainLRP5/6

LRP6 LRP5

4.44e-0521252IPR017049
DomainIon_trans_dom

KCNH7 TRPA1 TRPC5 RYR2 TPCN1 SLC9C1

1.18e-041141256IPR005821
DomainIon_trans

KCNH7 TRPA1 TRPC5 RYR2 TPCN1 SLC9C1

1.18e-041141256PF00520
Domain-

RASA4 RASA4B

1.33e-04312524.10.1130.10
Domain-

PLXNB2 RASA4 RASA4B

1.54e-041612531.10.506.10
DomainRasGAP_dom

PLXNB2 RASA4 RASA4B

2.22e-04181253IPR001936
DomainKinase-like_dom

VRK2 CDK12 ROR1 ADCK1 INSR PTK7 CHUK MAPK14 DST GUCY2D PEAK1 STKLD1

2.84e-0454212512IPR011009
DomainProt_kinase_dom

VRK2 CDK12 ROR1 ADCK1 INSR PTK7 CHUK MAPK14 GUCY2D PEAK1 STKLD1

4.49e-0448912511IPR000719
DomainPROTEIN_KINASE_DOM

VRK2 CDK12 ROR1 ADCK1 INSR PTK7 CHUK MAPK14 GUCY2D PEAK1 STKLD1

4.80e-0449312511PS50011
DomainEF-hand-dom_pair

EFCAB5 DTNA SPTAN1 EFCAB13 RYR2 TPCN1 DST PLCH2

7.03e-042871258IPR011992
DomainPInositol-4-P-5-kinase

PIP4K2A PIP4K2B

9.13e-0471252IPR023610
DomainPIPKc

PIP4K2A PIP4K2B

1.21e-0381252SM00330
Domain-

PIP4K2A PIP4K2B

1.21e-03812523.30.800.10
DomainPIP5K

PIP4K2A PIP4K2B

1.21e-0381252PF01504
DomainPIPK

PIP4K2A PIP4K2B

1.21e-0381252PS51455
DomainPInositol-4-P-5-kinase_N

PIP4K2A PIP4K2B

1.21e-0381252IPR027484
DomainPInositol-4-P-5-kinase_C

PIP4K2A PIP4K2B

1.21e-0381252IPR027483
Domain-

PIP4K2A PIP4K2B

1.21e-03812523.30.810.10
DomainPInositol-4-P-5-kinase_core

PIP4K2A PIP4K2B

1.21e-0381252IPR002498
DomainBTK

RASA4 RASA4B

1.55e-0391252SM00107
DomainZnf_Btk_motif

RASA4 RASA4B

1.55e-0391252IPR001562
DomainBTK

RASA4 RASA4B

1.55e-0391252PF00779
DomainZF_BTK

RASA4 RASA4B

1.55e-0391252PS51113
Domain-

EFCAB5 DTNA SPTAN1 EFCAB13 RYR2 DST PLCH2

1.89e-0326112571.10.238.10
DomainRECEPTOR_TYR_KIN_II

INSR PTK7

2.81e-03121252PS00239
DomainPROTEIN_KINASE_ATP

VRK2 CDK12 ROR1 ADCK1 INSR CHUK MAPK14 PEAK1 STKLD1

3.75e-034591259PS00107
DomainRasGAP

RASA4 RASA4B

3.84e-03141252SM00323
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH6

3.84e-03141252IPR024317
DomainDynein_HC_stalk

DYNC2H1 DNAH6

3.84e-03141252IPR024743
DomainDynein_heavy_dom-2

DYNC2H1 DNAH6

3.84e-03141252IPR013602
DomainDHC_N2

DYNC2H1 DNAH6

3.84e-03141252PF08393
DomainATPase_dyneun-rel_AAA

DYNC2H1 DNAH6

3.84e-03141252IPR011704
DomainMT

DYNC2H1 DNAH6

3.84e-03141252PF12777
DomainAAA_8

DYNC2H1 DNAH6

3.84e-03141252PF12780
DomainLdl_recept_b

LRP6 LRP5

3.84e-03141252PF00058
DomainLDLRB

LRP6 LRP5

3.84e-03141252PS51120
DomainRasGAP_CS

RASA4 RASA4B

3.84e-03141252IPR023152
DomainAAA_5

DYNC2H1 DNAH6

3.84e-03141252PF07728
DomainPROTEIN_KINASE_TYR

ROR1 INSR PTK7 PEAK1

4.10e-03971254PS00109
DomainTyr_kinase_AS

ROR1 INSR PTK7 PEAK1

4.10e-03971254IPR008266
Domain-

MTG1 DYNC2H1 WRN SRCAP NKIRAS1 PAPSS2 NWD2 DHX35 ATL2 POLQ DNAH6 ATP5F1B

4.31e-03746125123.40.50.300
DomainDHC_fam

DYNC2H1 DNAH6

4.41e-03151252IPR026983
DomainRasGAP

RASA4 RASA4B

4.41e-03151252PF00616
DomainRAS_GTPASE_ACTIV_1

RASA4 RASA4B

4.41e-03151252PS00509
DomainDynein_heavy

DYNC2H1 DNAH6

4.41e-03151252PF03028
DomainLY

LRP6 LRP5

4.41e-03151252SM00135
DomainRAS_GTPASE_ACTIV_2

RASA4 RASA4B

4.41e-03151252PS50018
DomainDynein_heavy_dom

DYNC2H1 DNAH6

4.41e-03151252IPR004273
DomainLDLR_classB_rpt

LRP6 LRP5

4.41e-03151252IPR000033
DomainP-loop_NTPase

MTG1 DYNC2H1 MYO9B WRN SRCAP NKIRAS1 PAPSS2 NWD2 DHX35 ATL2 POLQ DNAH6 ATP5F1B

4.48e-0384812513IPR027417
DomainEF_HAND_2

EFCAB5 SPTAN1 EFCAB13 RYR2 DST PLCH2

4.64e-032311256PS50222
DomainKringle_CS

KREMEN1 ROR1

5.66e-03171252IPR018056
DomainKRINGLE_1

KREMEN1 ROR1

5.66e-03171252PS00021
DomainKR

KREMEN1 ROR1

5.66e-03171252SM00130
DomainKringle

KREMEN1 ROR1

5.66e-03171252IPR000001
DomainKRINGLE_2

KREMEN1 ROR1

5.66e-03171252PS50070
DomainKringle

KREMEN1 ROR1

5.66e-03171252PF00051
DomainHelicase_C

WRN SRCAP DHX35 POLQ

5.81e-031071254PF00271
DomainHELICc

WRN SRCAP DHX35 POLQ

5.81e-031071254SM00490
DomainHelicase_C

WRN SRCAP DHX35 POLQ

6.00e-031081254IPR001650
DomainHELICASE_CTER

WRN SRCAP DHX35 POLQ

6.20e-031091254PS51194
DomainHELICASE_ATP_BIND_1

WRN SRCAP DHX35 POLQ

6.20e-031091254PS51192
DomainDEXDc

WRN SRCAP DHX35 POLQ

6.20e-031091254SM00487
DomainHelicase_ATP-bd

WRN SRCAP DHX35 POLQ

6.40e-031101254IPR014001
DomainC1_1

MYO9B GMIP PDZD8

6.58e-03571253PF00130
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPA1 TRPC5 RYR2 TPCN1 SLC9C1 CLCN7 CLCA2

3.67e-06106867M27200
PathwayREACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS

KREMEN1 LRP6 LRP5

1.20e-058863MM14976
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPA1 TRPC5 RYR2 TPCN1 SLC9C1 CLCN7 CLCA2 ATP11A

1.55e-05183868M997
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPA1 TRPC5 RYR2 TPCN1 CLCN7 CLCA2

3.08e-0599866MM14910
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY

WRN TAF3 MAPK14 CSNK2B PIP4K2A PIP4K2B TAF5

4.78e-05157867MM15226
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY

WRN TAF3 MAPK14 CSNK2B PIP4K2A PIP4K2B TAF5

5.39e-05160867M27498
PathwayREACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS

KREMEN1 LRP6 LRP5

9.46e-0515863M27273
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPA1 TRPC5 RYR2 TPCN1 CLCN7 CLCA2 ATP11A

9.83e-05176867MM15718
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

KREMEN1 ROR1 CSNK2B LRP6 LRP5

2.09e-0489865M39563
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION

WRN TAF3 MAPK14 CSNK2B TAF5

2.44e-0492865MM15338
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION

WRN TAF3 MAPK14 CSNK2B TAF5

2.44e-0492865M27636
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

KREMEN1 ROR1 CSNK2B LRP6 LRP5

3.27e-0498865M39731
PathwayWP_WNTBETACATENIN_SIGNALING_INHIBITORS_IN_CURRENT_AND_PAST_CLINICAL_TRIALS

LRP6 LRP5

3.64e-045862M48304
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53

CDK12 WRN TAF3 MAPK14 CSNK2B PIP4K2A PIP4K2B TAF5

5.27e-04304868MM14960
PathwayREACTOME_SIGNALING_BY_LRP5_MUTANTS

KREMEN1 LRP5

5.43e-046862M27432
PathwayWP_WNT_SIGNALING_WP428

KREMEN1 ROR1 CSNK2B LRP6 LRP5

6.29e-04113865M39669
PathwayPID_WNT_SIGNALING_PATHWAY

KREMEN1 LRP6 LRP5

6.43e-0428863M77
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

7.77e-119128536272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

7.84e-1013128515611625
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

EFCAB5 FAM114A1 DTNA SPTAN1 HEATR1 SRCAP EPX RYR2 PPP4R4 PTK7 CHUK IVD DST NRXN1 SACS FAM186A PIP4K2A RPF2 PIP4K2B ATP11A POLQ DNAH6 ATP5F1B

2.86e-0914421282335575683
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.73e-0917128515574121
Pubmed

Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.

KREMEN1 LRP6 LRP5

1.94e-074128318502762
Pubmed

Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.

KREMEN1 LRP6 LRP5

1.94e-074128320846389
Pubmed

Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.

LRP6 LRP5

1.34e-052128221887268
Pubmed

PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.

LRP6 LRP5

1.34e-052128233136328
Pubmed

Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism.

INSR LRP5

1.34e-052128228938444
Pubmed

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

RASA4 RASA4B

1.34e-052128211448776
Pubmed

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.

LRP6 LRP5

1.34e-052128215084453
Pubmed

The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation.

CXCR3 MAPK14

1.34e-052128215578697
Pubmed

Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.

LRP6 LRP5

1.34e-052128233164872
Pubmed

LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.

LRP6 LRP5

1.34e-052128225902418
Pubmed

The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.

LRP6 LRP5

1.34e-052128230474181
Pubmed

In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.

LRP6 LRP5

1.34e-052128236552732
Pubmed

Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.

LRP6 LRP5

1.34e-052128225783012
Pubmed

Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.

LRP6 LRP5

1.34e-052128219147944
Pubmed

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.

LRP6 LRP5

1.34e-052128215537447
Pubmed

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.

LRP6 LRP5

1.34e-052128217335347
Pubmed

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.

LRP6 LRP5

1.34e-052128219503830
Pubmed

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.

PIP4K2A PIP4K2B

1.34e-052128229727621
Pubmed

LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.

LRP6 LRP5

1.34e-052128237202775
Pubmed

Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.

LRP6 LRP5

1.34e-052128220926594
Pubmed

Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.

LRP6 LRP5

1.34e-052128216355283
Pubmed

Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.

LRP6 LRP5

1.34e-052128228425175
Pubmed

Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.

LRP6 LRP5

1.34e-052128218350154
Pubmed

Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).

LRP6 LRP5

1.34e-052128233118644
Pubmed

Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.

LRP6 LRP5

1.34e-052128218493104
Pubmed

Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.

LRP6 LRP5

1.34e-052128230668923
Pubmed

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

LRP6 LRP5

1.34e-052128222433869
Pubmed

Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice.

WRN OCA2

1.34e-052128218639560
Pubmed

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.

LRP6 LRP5

1.34e-052128225802278
Pubmed

Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling.

NPR3 MAPK14

1.34e-052128228659173
Pubmed

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.

LRP6 LRP5

1.34e-052128233545636
Pubmed

An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.

RASA4 RASA4B

1.34e-052128216041389
Pubmed

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.

LRP6 LRP5

1.34e-052128212579474
Pubmed

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.

NPR3 MAPK14

1.34e-052128222307324
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

XRN2 MYO9B INSR HEATR1 SRCAP PLXNB2 BLMH DST SACS BBS7 CSNK2B RPF2 UHRF1 ATP5F1B

2.61e-0510241281424711643
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

EFCAB5 KREMEN1 MYO9B CDK12 HEATR1 SPDYE18 CLCA2 CSHL1 SPDYE2 FHIP1A

3.98e-055521281010737800
Pubmed

Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes.

PIP4K2A PIP4K2B

4.02e-053128230718367
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE2 SPDYE6

4.02e-053128222763696
Pubmed

Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.

LRP6 LRP5

4.02e-053128224412065
Pubmed

Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.

LRP6 LRP5

4.02e-053128218524778
Pubmed

Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

LRP6 LRP5

4.02e-053128225710911
Pubmed

CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.

RASA4 RASA4B

4.02e-053128225637021
Pubmed

Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.

LRP6 LRP5

4.02e-053128227803037
Pubmed

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.

PIP4K2A PIP4K2B

4.02e-053128225495341
Pubmed

p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.

CHUK MAPK14

4.02e-053128218704119
Pubmed

Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.

LRP6 LRP5

4.02e-053128218406176
Pubmed

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.

ROR1 PTK7

4.02e-053128232619402
Pubmed

Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.

PIP4K2A PIP4K2B

4.02e-053128223758345
Pubmed

Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.

LRP6 LRP5

4.02e-053128221866564
Pubmed

Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated with hypothalamic hamartoma.

DYNC2H1 KATNIP

4.02e-053128231197031
Pubmed

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

PIP4K2A PIP4K2B

4.02e-053128226774281
Pubmed

Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.

LRP6 LRP5

4.02e-053128229602775
Pubmed

LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children.

LRP6 LRP5

4.02e-053128218721193
Pubmed

tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.

LRP6 LRP5

4.02e-053128223925701
Pubmed

The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.

LRP6 LRP5

4.02e-053128222589387
Pubmed

Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.

LRP6 LRP5

4.02e-053128225959626
Pubmed

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.

LRP6 LRP5

4.02e-053128221397183
Pubmed

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

LRP6 LRP5

4.02e-053128222000856
Pubmed

Molecular simulation analysis of the structure complex of C2 domains of DKK family members and β-propeller domains of LRP5/6: explaining why DKK3 does not bind to LRP5/6.

LRP6 LRP5

4.02e-053128224743782
Pubmed

Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.

LRP6 LRP5

4.02e-053128233650028
Pubmed

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

PIP4K2A PIP4K2B

4.02e-053128224209622
Pubmed

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.

LRP6 LRP5

4.02e-053128230664649
Pubmed

Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.

LRP6 LRP5

4.02e-053128222576936
Pubmed

Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.

PIP4K2A PIP4K2B

4.02e-053128234001596
Pubmed

Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.

LRP6 LRP5

4.02e-053128225009587
Pubmed

Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.

KREMEN1 LRP6

4.02e-053128227524201
Pubmed

TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.

LRP6 LRP5

4.02e-053128233065966
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

DTNA ROR1 EPB41L5 CDCP1 PTK7 BLMH CLCN7 ATP11A PEAK1 SLITRK6

5.13e-055691281030639242
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MYO9B CDK12 SRCAP PLXNB2 TPCN1 DST CLCN7 BTBD7 TMEM132A LRP5 PDZD8 HAS3 ARAP1 WDR24

5.93e-0511051281435748872
Pubmed

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

VRK2 ROR1 INSR EPB41L5 VPS54 PTK7 CLCN7 LRP6 PEAK1

6.12e-05467128930194290
Pubmed

LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex.

CDK12 SPTAN1 UHRF1

7.12e-0522128325982273
Pubmed

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.

PIP4K2A PIP4K2B

8.02e-05412829367159
Pubmed

Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.

LRP6 LRP5

8.02e-054128226772978
Pubmed

PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.

PIP4K2A PIP4K2B

8.02e-054128233984270
Pubmed

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis.

KREMEN1 LRP5

8.02e-054128223041840
Pubmed

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.

LRP6 LRP5

8.02e-054128229176883
Pubmed

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.

LRP6 LRP5

8.02e-054128215908424
Pubmed

Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.

LRP6 LRP5

8.02e-054128223675479
Pubmed

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.

LRP6 LRP5

8.02e-054128231452509
Pubmed

Keratinocytes contribute to normal cold and heat sensation.

TRPA1 TRPC5

8.02e-054128232729832
Pubmed

Critical Endothelial Regulation by LRP5 during Retinal Vascular Development.

LRP6 LRP5

8.02e-054128227031698
Pubmed

Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.

RASA4 RASA4B

8.02e-054128216234249
Pubmed

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

PIP4K2A PIP4K2B

8.02e-054128231091439
Pubmed

Acute effects of zinc and insulin on arcuate anorexigenic proopiomelanocortin neurons.

TRPC5 INSR

8.02e-054128230521677
Pubmed

Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.

LRP6 LRP5

8.02e-054128222696217
Pubmed

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.

LRP6 LRP5

8.02e-054128221471202
Pubmed

Odontoblast TRPC5 channels signal cold pain in teeth.

TRPA1 TRPC5

8.02e-054128233771873
Pubmed

LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

INSR LRP6

8.02e-054128223395167
Pubmed

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.

RASA4 RASA4B

8.02e-054128221460216
Pubmed

The Wnt-β-Catenin-IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota.

LRP6 LRP5

8.02e-054128232917787
Pubmed

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.

LRP6 LRP5

8.02e-054128217002572
Pubmed

Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway.

LRP6 LRP5

8.02e-054128230361437
Pubmed

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.

LRP6 LRP5

8.02e-054128215064719
Pubmed

Potential contribution of ryanodine receptor 2 upregulation to cGMP/PKG signaling-induced cone degeneration in cyclic nucleotide-gated channel deficiency.

RYR2 GUCY2D

8.02e-054128232173907
Pubmed

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.

LRP6 LRP5

8.02e-054128211433302
Pubmed

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.

WRN OCA2

8.02e-054128211756244
Cytoband4p14

FAM114A1 NSUN7 NWD2

2.24e-044212834p14
Cytoband7q22.1

SPDYE2 RASA4B SPDYE2B SPDYE6

2.93e-0411312847q22.1
CytobandEnsembl 112 genes in cytogenetic band chr7q22

RASA4 SPDYE2 RASA4B SPDYE2B SPDYE6

3.88e-042191285chr7q22
CytobandEnsembl 112 genes in cytogenetic band chr4p14

FAM114A1 NSUN7 NWD2

8.90e-04671283chr4p14
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE2 SPDYE5 SPDYE2B SPDYE6

2.09e-0712844756
GeneFamilyEF-hand domain containing

EFCAB5 SPTAN1 EFCAB13 RYR2 DST PLCH2

5.46e-04219846863
GeneFamilyReceptor Tyrosine Kinases|CD molecules

ROR1 INSR PTK7

8.44e-0440843321
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA4 RASA4B

9.37e-0410842830
GeneFamilyLow density lipoprotein receptors

LRP6 LRP5

1.61e-0313842634
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

INSR ARMH1 ODAD4 NSUN7 UHRF1 CFAP70 DNAH6

1.64e-0619812776d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROR1 EPB41L5 SLC9C1 KIAA1958 LRP6 ATP11A FHIP1A

1.70e-0619912775f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell367C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CXCR3 PTK7 TCL1A GUCY2D STKLD1 FHIP1A

9.44e-061701276fbb7019c6fba87326702b51f6819ea1af5f3a9b7
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

ROR1 EPB41L5 PAPSS2 SLC9C1 DST FHIP1A

9.44e-061701276e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNH7 SYT17 OCA2 ITPRID1 NWD2 DNAH6

1.01e-05172127692e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

SYT17 ROR1 EPB41L5 SLC9C1 ATP11A FHIP1A

1.27e-051791276a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPR3 DTNA EFCAB13 EPB41L5 OCA2 FRY

1.35e-0518112765f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPR3 DTNA EFCAB13 EPB41L5 OCA2 FRY

1.35e-051811276c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DTNA PAPSS2 PTGIS PPP4R4 PTK7 PEAK1

1.39e-051821276c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DTNA PAPSS2 PTGIS PPP4R4 PTK7 PEAK1

1.39e-051821276dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYT17 ROR1 EPB41L5 PAPSS2 DST FHIP1A

1.62e-051871276d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

SYT17 ROR1 EPB41L5 PAPSS2 DST PEAK1

1.62e-05187127677f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

NPR3 EPX CDCP1 PTK7 DST PDZD8

1.72e-0518912762157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KREMEN1 NSUN7 PPP4R4 FRY CFAP70 FHIP1A

1.83e-05191127660ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

LRRC39 DTNA ROR1 RYR2 FRY FHIP1A

1.88e-051921276ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

DTNA ROR1 INSR RYR2 FRY FHIP1A

1.94e-051931276dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DTNA SYT17 ROR1 EPB41L5 PAPSS2 DST

2.05e-051951276a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

DTNA ROR1 INSR RYR2 FRY DST

2.05e-05195127675fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

ARMH1 ODAD4 NSUN7 PLCH2 CFAP70 DNAH6

2.05e-05195127660067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ROR1 EPB41L5 PAPSS2 DST ATP11A PEAK1

2.11e-0519612766731fef8c148b6681d6ed38afdf23c8213e0bbbe
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

KREMEN1 ADH7 DST CLCA2 PLCH2 SLITRK6

2.11e-0519612763b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ROR1 EPB41L5 PAPSS2 DST ATP11A PEAK1

2.11e-0519612766856317cd0cdcb88fe54b4ae905d91e13495b1c4
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

DYNC2H1 SYT17 SLC9C1 CFAP70 DNAH6 FHIP1A

2.11e-05196127687d9881cfec461a5d89b688a83749b618c519485
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROR1 EPB41L5 SLC9C1 KIAA1958 ATP11A FHIP1A

2.30e-051991276725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DYNC2H1 PAPSS2 PTK7 DST PEAK1 SLITRK6

2.30e-05199127630d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-MEP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

NPR3 BLMH FAM186A PDZD8 CFAP70

4.59e-0513712750bb5cccc31e7c44d44a2db3f59b68f9a81503151
ToppCellTCGA-Uvea|World / Sample_Type by Project: Shred V9

LRRC39 EFCAB5 OCA2 CLCN7 PIP4K2A

5.27e-051411275015451a83087f2705d3315ebc8f23797c6f10ed6
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_2|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

ADH7 CLCA2 PLCH2 SLITRK6 HAS3

7.75e-051531275a44da11a913b19edde6c5d1d6e625c24b20ecbfd
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5_FEZF2_DYRK2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROR1 CDCP1 PAPSS2 SLC9C1 FHIP1A

9.58e-051601275e2504c6deba4949a3a716a9ca68755f787bc0ae0
ToppCelllung-Club_Cells|lung / shred on tissue and cell subclass

PAPSS2 ADH7 DST CLCA2 SLITRK6

1.08e-041641275b12cacd499b18b96120ca6d14646aebeaed41d10
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH7 NSUN7 CFAP70 DNAH6 FHIP1A

1.11e-0416512750c714e852f912b5749de4cb0895406673979b2e6
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTG1 EPB41L5 USP10 CLCA2 KIAA1958

1.11e-041651275936581de8fcd097401707438b9bbe89dd4e3e247
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH7 NSUN7 CFAP70 DNAH6 FHIP1A

1.11e-04165127582530f96aaefe28a13bad0474bbad043f127a86c
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INSR FSIP2 TCL1A ZNF90 SLITRK6

1.14e-04166127560060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INSR FSIP2 TCL1A ZNF90 SLITRK6

1.14e-041661275ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INSR FSIP2 TCL1A ZNF90 SLITRK6

1.14e-0416612754586d6725403f879fc96f67be579022587ce1906
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

DYNC2H1 ODAD4 ADH7 CFAP70 DNAH6

1.17e-04167127526cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EFCAB5 CXCR3 LINGO2 BLMH NRXN1

1.17e-041671275ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM114A1 VPS54 SERPINB9 DST FHIP1A

1.20e-04168127504a7810f95196a21325356b42084f96c11af5964
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROR1 CDCP1 PAPSS2 SLC9C1 FHIP1A

1.20e-0416812753e09516e819cf140a6dbf8f85247d3f08aa35bb8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROR1 CDCP1 PAPSS2 SLC9C1 FHIP1A

1.20e-0416812754a2e08b047f7170ae4b95eac9b2b128e55beee4a
ToppCellCV-Mild-7|CV / Virus stimulation, Condition and Cluster

EFCAB5 WASHC4 HEATR1 NKIRAS1 TPCN1

1.27e-04170127525ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNH7 SYT17 OCA2 ITPRID1 DNAH6

1.42e-0417412752947e5906b172d149412fa4e77476fce4ea695d2
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

ROR1 EPB41L5 PAPSS2 DST ATP11A

1.42e-041741275548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

DTNA ROR1 RYR2 FRY SLC9C1

1.50e-0417612759df7a124ebafb0087da0cda133a394275d7bed81
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DTNA LINGO2 EPX DST NRXN1

1.54e-041771275d05497d2c80a66ec6a4e1733fea3a5534877a6a7
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ROR1 EPB41L5 SLC9C1 ATP11A FHIP1A

1.62e-041791275cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRPA1 KREMEN1 DYNC2H1 FRY SLITRK6

1.62e-041791275a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SH3TC2 PAPSS2 DST DNAH6 FHIP1A

1.75e-041821275a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

DTNA ROR1 RYR2 FRY SLC9C1

1.75e-041821275287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DTNA LINGO2 EPX DST NRXN1

1.75e-041821275ecb5624c9074cc6449fad961df54c926c2681d54
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

SYT17 ROR1 EPB41L5 SLC9C1 FHIP1A

1.79e-041831275942530449e9c6583705eeb8f6f12621daea57252
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPA1 LINGO2 PAPSS2 PTK7 NWD2

1.79e-041831275274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ROR1 EPB41L5 DST ATP11A PEAK1

1.84e-04184127557c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

DTNA ROR1 RYR2 FRY DST

1.84e-041841275ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ROR1 EPB41L5 DST ATP11A PEAK1

1.84e-041841275d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D175|Adult / Lineage, Cell type, age group and donor

ROR1 EPB41L5 PAPSS2 DST PEAK1

1.89e-04185127532b4e68e551d435a732f253f6ad83408c759a642
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPR3 EFCAB13 EPB41L5 OCA2 FRY

1.89e-04185127534fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPR3 EFCAB13 EPB41L5 OCA2 FRY

1.89e-0418512758816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EPB41L5 PPP4R4 ATP11A ATL2 FHIP1A

1.93e-0418612752ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

DTNA ROR1 RYR2 FRY DST

1.98e-041871275464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 LINGO2 PAPSS2 DST FHIP1A

1.98e-04187127577886f99c229610abd28c4c370d2c7d1536c9782
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

ADH7 CLCA2 PLCH2 SLITRK6 FHIP1A

1.98e-0418712758407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DTNA ROR1 RYR2 SLC9C1 SLITRK6

2.03e-0418812753177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

ROR1 EPB41L5 SLC9C1 ATP11A FHIP1A

2.03e-041881275707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

LRRC39 DTNA ROR1 RYR2 FRY

2.08e-0418912759c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

NRXN1 RASA4 PIP4K2A TBC1D12 SPRTN

2.08e-0418912753717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ROR1 EPB41L5 FRY ATP11A FHIP1A

2.14e-0419012758aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

LRRC39 DTNA ROR1 RYR2 DST

2.19e-04191127525f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NPR3 DTNA PTGIS PPP4R4 PEAK1

2.19e-041911275e7c605b56934d1383237c1f946dbccef25d91368
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

ROR1 EPB41L5 SLC9C1 ATP11A FHIP1A

2.19e-041911275d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellIPF-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

SH3TC2 NPR3 ROR1 PAPSS2 PTGIS

2.24e-041921275e911e286da26202853f9650ba3cdefe5a5c9b585
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

ROR1 EPB41L5 LRP6 ATP11A FHIP1A

2.24e-041921275efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNH7 ROR1 LINGO2 PAPSS2 PTGIS

2.24e-04192127525460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellfacs-Aorta-Heart-3m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROR1 PLXNB2 PTGIS PTK7 ATP11A

2.24e-0419212750dc1f46e40346ed0b286e53b106a812441575100
ToppCellIPF-Epithelial-Ciliated|IPF / Disease state, Lineage and Cell class

DYNC2H1 SYT17 ODAD4 CFAP70 DNAH6

2.24e-041921275354adc1354bf596fbc60dd45c0169688e6f45165
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

DTNA RYR2 PTK7 DST PEAK1

2.24e-04192127562904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR3 PPP4R4 PEAK1 SLITRK6 ARAP1

2.30e-0419312758d05805295c5d3aa93aeb38be5fbefa81e1be1f0
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR3 PPP4R4 PEAK1 SLITRK6 ARAP1

2.30e-0419312751b2cc627b2aa002b442358bd1188d470e67ce7d9
ToppCellcontrol-pDC|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CXCR3 PTK7 TCL1A LRP5 FHIP1A

2.30e-04193127530a6559c9a9e8941861cb259b4836acccc427e68
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITPRID1 CLCA2 BNIPL ATP11A PLSCR2

2.35e-0419412750ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DTNA ROR1 PTGIS RYR2 FRY

2.35e-0419412755c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DTNA ROR1 PTGIS RYR2 FRY

2.35e-041941275ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARMH1 CDCP1 ADH7 NRXN1 PLCH2

2.41e-041951275ed052c6d3dc104b02e34b645abfdee477af050c6
ToppCellfacs-Tongue|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDCP1 ADH7 PLCH2 BNIPL TMEM132A

2.41e-04195127577128895db9221a64a171082d468ebcd6380c936
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ROR1 EPB41L5 SLC9C1 ATP11A FHIP1A

2.41e-0419512759406866f99555198a9be311fbd65751b70f35446
ToppCelldistal-Epithelial-Proximal_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADH7 CLCA2 BNIPL PLSCR2 SLITRK6

2.47e-041961275c102b28d5d1d90b9f7024cb51114276354be26a5
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LINGO2 RYR2 FRY MAN1A2 NRXN1

2.47e-041961275676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCelldistal-Epithelial-Proximal_Basal-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADH7 CLCA2 BNIPL PLSCR2 SLITRK6

2.47e-041961275a543d4623096cb3f9170dbf7af52381e77aa435e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell|GW09 / Sample Type, Dataset, Time_group, and Cell type.

VRK2 SYT17 TPCN1 DHX35 DNAH6

2.47e-0419612757be50b9156394dea44d7b8b476d4dd516abfafae
ToppCelldistal-3-Epithelial-Proximal_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADH7 CLCA2 BNIPL PLSCR2 SLITRK6

2.47e-0419612757e1a565dd2da4f375cbce8842ba4fd6c22ac8375
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CXCR3 SERPINB9 TCL1A UHRF1 FHIP1A

2.47e-041961275b10b386aacc672949560df2dbb0d4f76cf62e213
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DYNC2H1 RYR2 PTK7 IVD DST

2.52e-041971275fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SH3TC2 ADH7 CLCA2 PLCH2 TMEM132A

2.52e-041971275751f19b00f92e1334f653b870d3f7c0c149ff41a
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|Epithelial / Condition, Lineage and Cell class

ADH7 MMEL1 CLCA2 TMEM132A SLITRK6

2.52e-04197127578ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DTNA PTGIS RYR2 FRY SACS

2.52e-041971275bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 ODAD4 ADH7 CFAP70 DNAH6

2.52e-04197127591637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 ODAD4 ADH7 CFAP70 DNAH6

2.52e-04197127522c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYT17 ROR1 EPB41L5 PAPSS2 DST

2.52e-0419712758d5097898dd01cedb04cb694cb480c931e08462c
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

ADH7 DST CLCA2 PLCH2 SLITRK6

2.52e-04197127524360b660000bdfb999d58fbf4e29585a97e1785
DrugCephaeline dihydrochloride heptahydrate [6487-30-5]; Down 200; 6uM; MCF7; HT_HG-U133A

FAM114A1 SPTAN1 INSR PAPSS2 MAN1A2 SACS PIP4K2B ARAP1

6.59e-0618012483290_DN
Drugv 110

DTNA INSR MMEL1

8.66e-0681243CID000198155
DrugPyrithyldione [77-04-3]; Down 200; 24uM; HL60; HT_HG-U133A

OLAH DYNC2H1 PAPSS2 IVD ZBTB25 LRP6 LRP5 ATP11A

1.18e-0519512482740_DN
DrugDiethylcarbamazine citrate [1642-54-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

MYO9B SRCAP RYR2 TPCN1 BTBD7 DHX35 ATP11A ATL2

1.27e-0519712487425_DN
Drugdexamethasone; Up 200; 1uM; MCF7; HG-U133A

MYO9B DTNA VPS54 IVD CLCN7 LRP5 PIP4K2B ARAP1

1.32e-051981248123_UP
DiseaseAutosomal dominant osteopetrosis

CLCN7 LRP5

1.70e-0521222cv:C4272579
Diseasediabetic neuropathy (implicated_via_orthology)

TRPA1 INSR MAPK14

2.43e-05141223DOID:9743 (implicated_via_orthology)
Diseasehippocampal CA4 volume

EFCAB5 GMIP ITPRID1 TMEM132A

2.50e-05411224EFO_0009396
Diseasealcohol dependence measurement

FAM114A1 LINGO2 ADH7 ARAP1

8.06e-05551224EFO_0007835
DiseaseMetastatic melanoma

ROR1 GUCY2D PEAK1

1.47e-03541223C0278883
Diseaseearly cardiac repolarization measurement

LRP5 PDZD8

1.49e-03141222EFO_0004885
Disease4-acetamidobutanoate measurement

PLXNB2 DENND6B

1.96e-03161222EFO_0021003
DiseaseMultiple congenital anomalies

CHUK NRXN1

2.21e-03171222C0000772
Diseaseexercise test

WRN RYR2

3.07e-03201222EFO_0004328
Diseaseosteoporosis (biomarker_via_orthology)

CSHL1 LRP5

3.71e-03221222DOID:11476 (biomarker_via_orthology)
Diseasegestational diabetes

SLITRK6 ARAP1

4.05e-03231222EFO_0004593
Diseasereticulocyte count

MYO9B INSR ODAD4 PTDSS2 PLXNB2 USP10 SERPINB9 LRP5 AKAP10 ATP11A ATP5F1B

4.10e-03104512211EFO_0007986

Protein segments in the cluster

PeptideGeneStartEntry
LYEDILLQMDFIHIA

TBC1D12

706

O60347
YTFEVIGHLETMIDA

ADH7

276

P40394
YHLVVLVDILMDLGA

CXCR3

271

P49682
HLERLYGMITDLFID

BBS7

666

Q8IWZ6
KAEIVLLDHGLYQML

ADCK1

331

Q86TW2
LLDHGLYQMLTEEFR

ADCK1

336

Q86TW2
LVFEYMDHDLMGLLE

CDK12

811

Q9NYV4
HDTIVLPYFIQFMEL

AKAP10

131

O43572
VIEDTMVYGHLLQDS

CDCP1

736

Q9H5V8
LGTMHLEVQYEAIEL

ARMH1

231

Q6PIY5
DYHLLKDLEEGIQML

CSHL1

141

Q14406
QVEILGGRYHDLLLM

FAM186B

296

Q8IYM0
LELTQSFIIPLEHYM

DENND6B

421

Q8NEG7
LYHEMIESGVINLKD

ATP5F1B

246

P06576
MFVEGFHDAILLYVL

NPR3

356

P17342
DLREMHTILADYFLG

NWD2

751

Q9ULI1
VYVEMLQILLPHFSD

MROH7

1081

Q68CQ1
EAQLIYRHLLGVEAM

RASA4

726

O43374
LMEALAHLHLIEYVG

OCA2

691

Q04671
EAQLIYRHLLGVEAM

RASA4B

726

C9J798
EYLQVMHFDTLLDDG

PAPSS2

276

O95340
VVIDNLLLGTMAYDH

OR1S1

121

Q8NH92
SFREYLEEIEQHLMG

ITPRID1

876

Q6ZRS4
MHSVLLGGEEQRYLL

GUCY2D

246

Q02846
VEFLIVHYEQIFGMD

GMIP

746

Q9P107
ILGKNDIFGEMVHLY

KCNH7

801

Q9NS40
LEEFNDVYLVTHLMG

MAPK14

96

Q16539
HMYEKTIAEGENLLL

DST

4901

Q03001
VIGYLEDQIMSLHAE

CHUK

526

O15111
DDLLVYNGILAMVSH

KATNIP

1521

O60303
LEQLLYGNHTIGMED

NKIRAS1

21

Q9NYS0
LIQGHLDFVMDILVF

LRP5

881

O75197
EERELFGLQFMHTYI

LRRC39

296

Q96DD0
EHLFRYMVGTLELLV

BNIPL

236

Q7Z465
SLLEDMVYRLLGHVF

FSIP2

5116

Q5CZC0
VFIEGLYDMHIQLQS

CLCN7

596

P51798
VLDHLVGEETMADYL

MTG1

226

Q9BT17
GLEYLSQIDMILIHQ

PLSCR2

86

Q9NRY7
TDIMHTLFLELLEQY

PLXNB2

1366

O15031
VYVELLFLTIMAHDR

OR14C36

106

Q8NHC7
ALTLLMIHYRAGIED

PDZD8

1086

Q8NEN9
MIHYRAGIEDIETLE

PDZD8

1091

Q8NEN9
DYMHVALGLLEEKLQ

EPX

91

P11678
DEFQTGILIYEMLHL

PEAK1

1591

Q9H792
RTIIQGHLDYVMDIL

LRP6

866

O75581
DMVELLDGYTHRVLA

KREMEN1

266

Q96MU8
IVILLDYMFQDLHNL

LINGO2

141

Q7L985
VIFEMVHLKELGLYN

INSR

121

P06213
FAIEMLDGHLYLLLD

NRXN1

541

Q9ULB1
ADMAAYQLELHGIEL

PSMB9

76

P28065
LGYLEHVLVMEEISR

IVD

106

P26440
HDVIALYHRMGLEEL

MMEL1

326

Q495T6
DILLFHEVLEYMSRI

DYNC2H1

2626

Q8NCM8
LLEDYQFVHPTFLEM

DYNC2H1

2711

Q8NCM8
LLNSMEFVSLLLYDH

EFCAB5

1341

A4FU69
QELFDQIMYHLDLIE

EPB41L5

66

Q9HCM4
KIIRENEHLGFLYMI

DNAH6

191

Q9C0G6
NYVEHMLFLLIEEQA

FHIP1A

66

Q05DH4
ISELYVFLVDQMHVA

CFAP70

601

Q5T0N1
EEGDHLTMLNIYEAF

DHX35

541

Q9H5Z1
NDLHILYLVTPMFED

POLQ

646

O75417
HLQLFTEYGRLAMEE

ATL2

216

Q8NHH9
LIEQAAEMLYGLIHA

CSNK2B

71

P67870
RAEEAMELYHIALFL

BTBD7

366

Q9P203
LGLSDMNLYDHELVF

BLMH

336

Q13867
YIDSNHMVDIGDIIF

EFCAB13

266

Q8IY85
LDTLYIMGLHDEFLD

MAN1A2

231

O60476
RLADEHVLIGLYVNM

DTNA

401

Q9Y4J8
MEFHYVAQADLELLT

ARRDC1-AS1

1

Q9H2J1
YMLDIFHEVLGGTEQ

HAS3

131

O00219
DSRDYLHLLIGLFEM

HEATR1

821

Q9H583
MHIVADLYAEVIGVL

FRY

221

Q5TBA9
IEILHMDTVQLGYLF

FAM186A

2141

A6NE01
ELSEEQISHYLMEFG

OLAH

146

Q9NV23
ILLEIYGFMHDHLNE

SACS

1251

Q9NZJ4
YTLLIMGIFHNEDLK

RYR2

1826

Q92736
LMDYSLLVGIHDVER

PIP4K2A

271

P48426
TLEHLNQMVGIEYIL

MED6

56

O75586
MLFDEYQGLSHLEAL

FAM114A1

291

Q8IWE2
QLMGVSLHELEDYIH

TAF3

71

Q5VWG9
NIVQEHLYIDIFDGM

TAF5

331

Q15542
SLFGYMEDLQELTII

PPP4R4

16

Q6NUP7
SDLVEYFTLEMLHLG

SLITRK6

381

Q9H5Y7
EEFEHVGYLVILMNI

SLC9C1

611

Q4G0N8
DEEILSKYQLGMLHF

SYT17

176

Q9BSW7
QHVTELELGMYALLG

TMEM132A

841

Q24JP5
LESYLLHLEEMGVSE

PTGIS

256

Q16647
LETFMQGDYLLDELV

MTRF1L

346

Q9UGC7
DHLSSLIIVMLYDFQ

NSUN7

121

Q8NE18
VEDLIMTGINYLDTH

ODAD4

221

Q96NG3
IMDYSLLVGIHDVDR

PIP4K2B

276

P78356
SVMFEFLEYSLEHQL

PTDSS2

221

Q9BVG9
GRLHYLMQEDELVEL

SH3TC2

1051

Q8TF17
LVHVEIYILAVMAFD

OR5M8

106

Q8NGP6
ENIDTYLIHMAIEIL

WRN

1341

Q14191
MLDVLEQFLTYHGHL

SRCAP

2071

Q6ZRS2
IHFFLALYLANDMEE

SPDYE2B

246

A6NHP3
YHVLDMIELGIENFV

RPF2

111

Q9H7B2
YHIKIDGVEDMLLEL

TCL1A

96

P56279
LEEYHLGIGITFIDM

ARAP1

471

Q96P48
EFYLMQIVEIHTFVG

CLCA2

336

Q9UQC9
LYSLMEQHVGIDVLK

ATP11A

931

P98196
TDIQPDIFSYLLHIM

ZBTB25

66

P24278
DFLHIAIQIAAGMEY

ROR1

591

Q01973
FLHYAAAEGQIELME

TRPA1

66

O75762
EDYDMESVLRHLGIV

SERPINB9

276

P50453
EHLYQQGMLSVAEEL

RMND5B

126

Q96G75
VENVGMLLVHLASYE

STKLD1

611

Q8NE28
YLEGMEEASIFVHVA

PLCH2

866

O75038
IHFFLALYLANDMEE

SPDYE16

206

A6NNV3
IHFFLALYLANDMEE

SPDYE18

246

P0DV79
IHFFLALYLANDMEE

SPDYE21

246

A0A494C086
IHFFLALYLANDMEE

SPDYE2

246

Q495Y8
IHFFLALYLANDMEE

SPDYE5

246

A6NIY4
IHFFLALYLANDMEE

SPDYE6

246

P0CI01
MKQVEELYHSLLELG

SPTAN1

1066

Q13813
VEFDNLYLDMNGIIH

XRN2

46

Q9H0D6
RGQILTHIFEMYEEI

ZBED8

336

Q8IZ13
VETLLHEMIHAYLFV

SPRTN

106

Q9H040
GIYVHATLELFALMV

TPCN1

136

Q9ULQ1
QMEDGHTLFDYEVRL

UHRF1

51

Q96T88
DVMLENYRHLVFLGI

ZNF90

31

Q03938
FQTMYEHLGELLTVL

WASHC4

186

Q2M389
EYLGFILNGLHEEML

USP10

526

Q14694
IHFFLALYLANDMEE

nan

206

A6NJR5
MELLLNHSVYVGDAL

TRPC5

86

Q9UL62
LVRDMLHFYAEQGDV

WDR24

636

Q96S15
NLYTFLLALMDDVHL

TMC2

516

Q8TDI7
HYMVLEYVDLGDLKQ

PTK7

871

Q13308
LGIRMLDVLEYIHEN

VRK2

146

Q86Y07
TEVAYLIHEGMFISD

VPS54

506

Q9P1Q0
TLQEHADLMYGDIEL

KIAA1958

571

Q8N8K9
LEKLLEHVEMHGLYT

MYO9B

1716

Q13459