Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessactin filament severing

FLII MYH9 VILL

7.23e-0618443GO:0051014
GeneOntologyBiologicalProcessmuscle structure development

CFH WNT5B FLII MYH9 ACVR1 KAT5 PDLIM3 NEK5 CFHR4 SCN8A

1.01e-058584410GO:0061061
GeneOntologyBiologicalProcessactivation of membrane attack complex

CFH CFHR4

6.64e-056442GO:0001905
GeneOntologyBiologicalProcessgastrulation

WNT5B TRIM15 MYH9 ACVR1 MEGF8

8.58e-05212445GO:0007369
GeneOntologyBiologicalProcessregulation of complement activation, alternative pathway

CFH CFHR4

9.28e-057442GO:0030451
GeneOntologyBiologicalProcessmuscle cell differentiation

CFH WNT5B FLII MYH9 ACVR1 NEK5 CFHR4

1.21e-04531447GO:0042692
GeneOntologyBiologicalProcessactin filament capping

FLII MYH9 VILL

1.29e-0446443GO:0051693
GeneOntologyBiologicalProcessimmune complex clearance

CFH CFHR4

1.59e-049442GO:0002434
GeneOntologyBiologicalProcessmonocyte aggregation

CFH CFHR4

1.59e-049442GO:0070487
GeneOntologyBiologicalProcessnegative regulation of actin filament depolymerization

FLII MYH9 VILL

1.86e-0452443GO:0030835
GeneOntologyBiologicalProcessretinal pigment epithelium development

CFH CFHR4

1.98e-0410442GO:0003406
GeneOntologyBiologicalProcessnegative regulation of DNA recombination

MSH3 KAT5 HELB

2.20e-0455443GO:0045910
GeneOntologyBiologicalProcessblood vessel morphogenesis

CFH MYH9 ACVR1 MEGF8 TNFSF12 ADAMTS9 NOTCH3 CFHR4

2.92e-04817448GO:0048514
GeneOntologyBiologicalProcessregulation of actin filament depolymerization

FLII MYH9 VILL

2.99e-0461443GO:0030834
GeneOntologyBiologicalProcessregulation of complement-dependent cytotoxicity

CFH CFHR4

3.42e-0413442GO:1903659
GeneOntologyBiologicalProcessactin filament depolymerization

FLII MYH9 VILL

3.77e-0466443GO:0030042
GeneOntologyBiologicalProcesscomplement-dependent cytotoxicity

CFH CFHR4

5.24e-0416442GO:0097278
GeneOntologyBiologicalProcessnegative regulation of actin filament polymerization

FLII MYH9 VILL

5.49e-0475443GO:0030837
GeneOntologyBiologicalProcessretinal rod cell development

CFH CFHR4

5.93e-0417442GO:0046548
GeneOntologyBiologicalProcessglomerulus development

CFH NOTCH3 CFHR4

5.93e-0477443GO:0032835
GeneOntologyBiologicalProcessblood vessel development

CFH MYH9 ACVR1 MEGF8 TNFSF12 ADAMTS9 NOTCH3 CFHR4

6.87e-04929448GO:0001568
GeneOntologyBiologicalProcessangiogenesis

CFH MYH9 ACVR1 TNFSF12 ADAMTS9 NOTCH3 CFHR4

6.91e-04708447GO:0001525
GeneOntologyBiologicalProcesscomplement activation, alternative pathway

CFH CFHR4

7.43e-0419442GO:0006957
GeneOntologyBiologicalProcessleukocyte aggregation

CFH CFHR4

7.43e-0419442GO:0070486
GeneOntologyBiologicalProcesscirculatory system development

CFH MYH9 ACVR1 PDLIM3 MEGF8 TNFSF12 ADAMTS9 VCAN NOTCH3 CFHR4

7.48e-0414424410GO:0072359
GeneOntologyBiologicalProcessregulation of innate immune response

CFH TRIM15 KAT5 TAX1BP1 CNOT7 CFHR4

7.73e-04519446GO:0045088
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

FLII MYH9 VILL

9.05e-0489443GO:1901880
GeneOntologyBiologicalProcessvasculature development

CFH MYH9 ACVR1 MEGF8 TNFSF12 ADAMTS9 NOTCH3 CFHR4

9.05e-04969448GO:0001944
GeneOntologyBiologicalProcessnegative regulation of protein polymerization

FLII MYH9 VILL

9.65e-0491443GO:0032272
GeneOntologyBiologicalProcessartery morphogenesis

MEGF8 ADAMTS9 NOTCH3

9.96e-0492443GO:0048844
GeneOntologyCellularComponentsymbiont cell surface

CFH CFHR4

1.20e-048442GO:0106139
GeneOntologyCellularComponentother organism part

CFH CFHR4

1.54e-049442GO:0044217
MousePhenoabnormal brain thrombosis

CFH NOTCH3 CFHR4

5.25e-084343MP:0031168
MousePhenowhite pupil

CFH CFHR4

5.74e-062342MP:0006242
MousePhenodecreased serum complement activity

CFH CFHR4

5.74e-062342MP:0012553
MousePhenoartery occlusion

CFH CFHR4

5.74e-062342MP:0006134
MousePhenodecreased complement C5 level

CFH CFHR4

5.74e-062342MP:0012609
MousePhenoabnormal complement C5 level

CFH CFHR4

5.74e-062342MP:0012608
MousePhenoabnormal hepatic portal vein thrombosis

CFH CFHR4

5.74e-062342MP:0031159
MousePhenohematuria

CFH MYH9 CFHR4

1.24e-0519343MP:0005161
MousePhenoincreased susceptilbility to retina ischemic injury

CFH CFHR4

1.72e-053342MP:0012049
MousePhenoabnormal kidney venous thrombosis

CFH CFHR4

1.72e-053342MP:0031161
MousePhenoabnormal response to retina ischemic injury

CFH CFHR4

3.43e-054342MP:0012048
MousePhenoincreased susceptibility to type III hypersensitivity reaction

CFH CFHR4

3.43e-054342MP:0005615
MousePhenodecreased circulating complement protein level

CFH CFHR4

3.43e-054342MP:0020216
MousePhenomesangial cell interposition

CFH CFHR4

3.43e-054342MP:0011512
MousePhenoincreased creatine level

CFH CFHR4

3.43e-054342MP:0010061
MousePhenoimpaired muscle relaxation

CFH CFHR4 SCN8A

4.13e-0528343MP:0003157
MousePhenoabnormal venous thrombosis

CFH CFHR4

5.72e-055342MP:0031158
MousePhenoabnormal lung thrombosis

CFH CFHR4

5.72e-055342MP:0031167
MousePhenoabnormal circulating complement protein level

CFH CFHR4

8.56e-056342MP:0010215
MousePhenoabnormal glomerular capillary thrombosis

CFH CFHR4

1.20e-047342MP:0011508
MousePhenobrain ischemia

CFH CFHR4

1.59e-048342MP:0006080
MousePhenoabnormal complement protein level

CFH CFHR4

2.05e-049342MP:0011566
MousePhenoabnormal creatine level

CFH CFHR4

2.05e-049342MP:0010060
MousePhenoabnormal type III hypersensitivity reaction

CFH CFHR4

2.55e-0410342MP:0002533
MousePhenoabnormal kidney thrombosis

CFH CFHR4

2.55e-0410342MP:0011507
MousePhenoabnormal muscle relaxation

CFH CFHR4 SCN8A

4.30e-0461343MP:0004036
MousePhenoabnormal visual acuity

CFH CFHR4

4.40e-0413342MP:0011832
MousePhenodecreased visual acuity

CFH CFHR4

4.40e-0413342MP:0006149
MousePhenoalbuminuria

CFH MYH9 CFHR4

4.73e-0463343MP:0002871
MousePhenoabnormal Bruch membrane morphology

CFH CFHR4

5.13e-0414342MP:0005239
MousePhenothin placenta labyrinth

MYH9 UBR4

5.13e-0414342MP:0011523
MousePhenoabnormal visceral endoderm morphology

MYH9 ACVR1 ADAMTS9

5.42e-0466343MP:0011186
MousePhenoretina detachment

CFH CFHR4

5.91e-0415342MP:0003099
MousePhenoamyloid beta deposits

CFH CFHR4

7.63e-0417342MP:0003329
MousePhenoabnormal gastrulation

MYH9 ACVR1 MEGF8 ADAMTS9 COPS5 VCAN

8.35e-04469346MP:0001695
MousePhenoincreased incidence of corneal inflammation

MYH9 PRMT3

8.57e-0418342MP:0001313
MousePhenohindlimb paralysis

CFH CFHR4 SCN8A

9.16e-0479343MP:0000755
MousePhenolimb paralysis

CFH CFHR4 SCN8A

1.06e-0383343MP:0013147
MousePhenoabnormal glomerular capillary endothelium morphology

CFH CFHR4

1.17e-0321342MP:0011453
MousePhenoabnormal retina rod bipolar cell morphology

CFH CFHR4

1.41e-0323342MP:0006074
MousePhenoabnormal embryo size

FLII MYH9 PRMT3 ACVR1 ADAMTS9 COPS5 VCAN UBR4

1.71e-03956348MP:0001697
MousePhenoabnormal placental labyrinth vasculature morphology

KIFBP MYH9 UBR4

1.76e-0399343MP:0008803
MousePhenoabnormal complement pathway

CFH CFHR4

1.80e-0326342MP:0002471
MousePhenoimpaired hearing

MYH9 NEK5 NOTCH3 SCN8A

2.01e-03223344MP:0006325
MousePhenoabnormal thrombosis

CFH NOTCH3 CFHR4

2.14e-03106343MP:0005048
MousePhenoenhanced wound healing

FLII VCAN

2.24e-0329342MP:0002724
MousePhenoincreased mesangial cell number

CFH CFHR4

2.24e-0329342MP:0011427
MousePhenodecreased susceptibility to induction of seizure by inducing agent

GRIA3 SCN8A

2.24e-0329342MP:0012348
MousePhenoabnormal vagus nerve morphology

KIFBP MEGF8

2.24e-0329342MP:0001074
MousePhenodecreased susceptibility to pharmacologically induced seizures

GRIA3 SCN8A

2.24e-0329342MP:0002887
MousePhenoabnormal developmental patterning

MYH9 ACVR1 MEGF8 ADAMTS9 COPS5 VCAN

2.41e-03577346MP:0002084
MousePhenodisorganized embryonic tissue

ACVR1 ADAMTS9

2.55e-0331342MP:0003988
DomainSushi

CFH PAMR1 VCAN CFHR4

6.08e-0652434PF00084
DomainCCP

CFH PAMR1 VCAN CFHR4

7.08e-0654434SM00032
DomainSUSHI

CFH PAMR1 VCAN CFHR4

8.20e-0656434PS50923
DomainSushi_SCR_CCP_dom

CFH PAMR1 VCAN CFHR4

8.80e-0657434IPR000436
DomainVillin/Gelsolin

FLII VILL

1.44e-048432IPR007122
DomainGEL

FLII VILL

1.44e-048432SM00262
DomainEGF_CA

MEGF8 PAMR1 VCAN NOTCH3

1.76e-04122434SM00179
DomainEGF-like_Ca-bd_dom

MEGF8 PAMR1 VCAN NOTCH3

1.87e-04124434IPR001881
DomainGelsolin

FLII VILL

4.63e-0414432PF00626
DomainGelsolin-like_dom

FLII VILL

4.63e-0414432IPR007123
DomainADF-H/Gelsolin-like_dom

FLII VILL

1.38e-0324432IPR029006
Domain-

FLII VILL

1.38e-03244323.40.20.10
DomainEGF_Ca-bd_CS

MEGF8 VCAN NOTCH3

1.44e-0397433IPR018097
DomainEGF_CA

MEGF8 VCAN NOTCH3

1.53e-0399433PS01187
DomainASX_HYDROXYL

MEGF8 VCAN NOTCH3

1.57e-03100433PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

MEGF8 VCAN NOTCH3

1.86e-03106433IPR000152
DomainEGF_3

MEGF8 PAMR1 VCAN NOTCH3

2.05e-03235434PS50026
DomainEGF

MEGF8 PAMR1 VCAN NOTCH3

2.05e-03235434SM00181
DomainEGF-like_dom

MEGF8 PAMR1 VCAN NOTCH3

2.53e-03249434IPR000742
DomainEGF_1

MEGF8 PAMR1 VCAN NOTCH3

2.76e-03255434PS00022
DomainEGF-like_CS

MEGF8 PAMR1 VCAN NOTCH3

3.00e-03261434IPR013032
DomainEGF

PAMR1 VCAN NOTCH3

3.04e-03126433PF00008
DomainEGF_2

MEGF8 PAMR1 VCAN NOTCH3

3.17e-03265434PS01186
DomainCUB

MEGF8 PAMR1

5.69e-0349432PF00431
DomainCUB

MEGF8 PAMR1

5.91e-0350432SM00042
Domain-

MEGF8 PAMR1

6.38e-03524322.60.120.290
DomainCUB

MEGF8 PAMR1

6.62e-0353432PS01180
DomainCUB_dom

MEGF8 PAMR1

7.63e-0357432IPR000859
DomainChannel_four-helix_dom

KCNF1 SCN8A

7.63e-0357432IPR027359
Domain-

KCNF1 SCN8A

7.63e-03574321.20.120.350
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR

CFH CFHR4

6.53e-056302M47880
Pubmed

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.

CFH CFHR4

1.56e-06244231354740
Pubmed

Absence of complement factor H reduces physical performance in C57BL6 mice.

CFH CFHR4

1.56e-06244232962822
Pubmed

Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.

CFH CFHR4

1.56e-06244220538999
Pubmed

Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2.

CFH CFHR4

1.56e-0624424992636
Pubmed

Retinal changes precede visual dysfunction in the complement factor H knockout mouse.

CFH CFHR4

1.56e-06244223844226
Pubmed

Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b.

CFH CFHR4

1.56e-0624428615824
Pubmed

Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site.

CFH CFHR4

1.56e-06244230642982
Pubmed

Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.

CFH CFHR4

1.56e-06244226374608
Pubmed

A gene locus concerned with an antigenic serum substance in Mus musculus.

CFH CFHR4

1.56e-0624424955525
Pubmed

Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells.

CFH CFHR4

1.56e-0624422533512
Pubmed

Complement factor H: spatial and temporal expression and localization in the eye.

CFH CFHR4

1.56e-06244216936129
Pubmed

Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.

CFH CFHR4

1.56e-06244233558624
Pubmed

Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.

CFH CFHR4

1.56e-06244229398083
Pubmed

Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.

CFH CFHR4

1.56e-06244237940659
Pubmed

Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin.

CFH CFHR4

1.56e-06244219620346
Pubmed

Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.

CFH CFHR4

1.56e-06244230705315
Pubmed

A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia.

CFH CFHR4

1.56e-06244233859044
Pubmed

Regulation of age-related macular degeneration-like pathology by complement factor H.

CFH CFHR4

1.56e-06244225991857
Pubmed

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

CFH CFHR4

1.56e-06244229288229
Pubmed

Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells.

CFH CFHR4

1.56e-06244233708358
Pubmed

Serological survey of complement factor H in common laboratory and wild mice: a new third allotype.

CFH CFHR4

1.56e-0624422522412
Pubmed

Absence of complement factor H alters bone architecture and dynamics.

CFH CFHR4

1.56e-06244230107932
Pubmed

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.

CFH CFHR4

1.56e-06244234054871
Pubmed

Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo.

CFH CFHR4

1.56e-06244217562771
Pubmed

Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.

CFH CFHR4

1.56e-06244227397653
Pubmed

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.

CFH CFHR4

1.56e-06244229392311
Pubmed

The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.

CFH CFHR4

1.56e-06244222174452
Pubmed

Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration.

CFH CFHR4

1.56e-06244228819420
Pubmed

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

CFH CFHR4

1.56e-06244222875704
Pubmed

Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome.

KAT5 RCHY1

1.56e-06244214701804
Pubmed

Local complement factor H protects kidney endothelial cell structure and function.

CFH CFHR4

1.56e-06244234139209
Pubmed

Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.

CFH CFHR4

1.56e-06244223799019
Pubmed

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.

CFH CFHR4

1.56e-06244232849636
Pubmed

Complement factor h is critical in the maintenance of retinal perfusion.

CFH CFHR4

1.56e-06244219541934
Pubmed

Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.

CFH CFHR4

1.56e-06244217921253
Pubmed

The role of complement dysregulation in AMD mouse models.

CFH CFHR4

1.56e-06244224664701
Pubmed

Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.

CFH CFHR4

1.56e-06244226149919
Pubmed

Murine protein H is comprised of 20 repeating units, 61 amino acids in length.

CFH CFHR4

1.56e-0624422940596
Pubmed

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.

CFH CFHR4

1.56e-06244232165615
Pubmed

Death by color: differential cone loss in the aging mouse retina.

CFH CFHR4

1.56e-06244224929970
Pubmed

Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice.

CFH CFHR4

1.56e-06244224370827
Pubmed

Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.

CFH CFHR4

1.56e-06244223436934
Pubmed

Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.

CFH CFHR4

1.56e-06244223469078
Pubmed

Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.

CFH CFHR4

1.56e-06244225921262
Pubmed

Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness.

CFH CFHR4

1.56e-06244215574507
Pubmed

Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.

CFH CFHR4

1.56e-06244223133374
Pubmed

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice.

CFH CFHR4

1.56e-06244230808757
Pubmed

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.

CFH CFHR4

1.56e-06244221544060
Pubmed

Role of ocular complement factor H in a murine model of choroidal neovascularization.

CFH CFHR4

1.56e-06244220813971
Pubmed

Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding.

CFH CFHR4

1.56e-0624421486806
Pubmed

A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice.

CFH CFHR4

1.56e-06244226030099
Pubmed

Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.

CFH CFHR4

1.56e-06244217517971
Pubmed

Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice.

CFH CFHR4

1.56e-06244220445496
Pubmed

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits.

CFH CFHR4

1.56e-06244231133737
Pubmed

High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.

CFH CFHR4

1.56e-06244232737203
Pubmed

Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease.

CFH CFHR4

1.56e-06244216597679
Pubmed

AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.

CFH CFHR4

1.56e-06244237471073
Pubmed

Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.

CFH CFHR4

1.56e-06244226802141
Pubmed

Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.

CFH CFHR4

1.56e-06244225447048
Pubmed

Structure of the murine complement factor H gene.

CFH CFHR4

1.56e-0624422972715
Pubmed

Complement factor H deficiency combined with smoking promotes retinal degeneration in a novel mouse model.

CFH CFHR4

1.56e-06244234775843
Pubmed

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.

FLII MYH9 PDLIM3

1.80e-061944316105984
Pubmed

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.

CFH CFHR4

4.69e-06344212091909
Pubmed

Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection.

CFH CFHR4

4.69e-06344217420242
Pubmed

Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis.

CFH CFHR4

4.69e-06344229070671
Pubmed

Altered expression patterns of complement factor H and miR-146a genes in acute-chronic phases in experimental autoimmune encephalomyelitis mouse.

CFH CFHR4

4.69e-06344230972735
Pubmed

Retinal Basal Laminar Deposits in Complement fH/fP Mouse Model of Dense Deposit Disease.

CFH CFHR4

4.69e-06344230025090
Pubmed

Comparison of surface recognition and C3b binding properties of mouse and human complement factor H.

CFH CFHR4

4.69e-06344216023208
Pubmed

Location of theSas-1 locus on mouse chromosome 1.

CFH CFHR4

4.69e-06344221302086
Pubmed

Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency.

CFH CFHR4

4.69e-06344223184055
Pubmed

DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells.

WNT5B NOTCH3

4.69e-06344237971882
Pubmed

Mesangial immune complex glomerulonephritis due to complement factor D deficiency.

CFH CFHR4

4.69e-06344217410102
Pubmed

C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice.

CFH CFHR4

4.69e-06344232376801
Pubmed

VEGF regulates local inhibitory complement proteins in the eye and kidney.

CFH CFHR4

4.69e-06344227918307
Pubmed

Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes.

CFH CFHR4

4.69e-06344220702729
Pubmed

TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling.

FLII MYH9

4.69e-06344228526784
Pubmed

Changes in complement alternative pathway components, factor B and factor H during dengue virus infection in the AG129 mouse.

CFH CFHR4

4.69e-06344233410734
Pubmed

Complement factor H-deficient mice develop spontaneous hepatic tumors.

CFH CFHR4

4.69e-06344232369457
Pubmed

Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.

CFH CFHR4

4.69e-06344216769899
Pubmed

Incorporating prior knowledge to facilitate discoveries in a genome-wide association study on age-related macular degeneration.

CFH CFHR4

4.69e-06344220181037
Pubmed

Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells.

CFH CFHR4

4.69e-06344219084272
Pubmed

Complement factor H deficiency accelerates development of lupus nephritis.

CFH CFHR4

4.69e-06344221148254
Pubmed

Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.

CFH CFHR4

4.69e-06344229389016
Pubmed

Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily.

CFH CFHR4

4.69e-06344229895552
Pubmed

Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.

CFH CFHR4

4.69e-06344219828624
Pubmed

Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse.

CFH CFHR4

4.69e-0634423156187
Pubmed

Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model.

CFH CFHR4

4.69e-06344220854881
Pubmed

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy.

CFH CFHR4

4.69e-06344231409673
Pubmed

Two factor H-related proteins from the mouse: expression analysis and functional characterization.

CFH CFHR4

4.69e-06344217028856
Pubmed

Localization of complement factor H gene expression and protein distribution in the mouse outer retina.

CFH CFHR4

4.69e-06344225684976
Pubmed

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

CFH CFHR4

4.69e-06344218202746
Pubmed

Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia.

CFH CFHR4

4.69e-06344229858280
Pubmed

Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration.

CFH CFHR4

4.69e-06344223747511
Pubmed

Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes.

CFH CFHR4

4.69e-06344226768663
Pubmed

Interleukin 27 induces the expression of complement factor H (CFH) in the retina.

CFH CFHR4

4.69e-06344223029250
Pubmed

The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice.

CFH CFHR4

9.37e-06444222832515
Pubmed

Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

CFH CFHR4

9.37e-06444227165610
Pubmed

Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse.

CFH CFHR4

9.37e-0644427410386
Pubmed

CD11b is protective in complement-mediated immune complex glomerulonephritis.

CFH CFHR4

9.37e-06444225565310
Pubmed

A2E accumulation influences retinal microglial activation and complement regulation.

CFH CFHR4

9.37e-06444222819137
Cytoband1q32

CFH CFHR4

1.03e-03494421q32
CytobandEnsembl 112 genes in cytogenetic band chr1q31

CFH CFHR4

2.38e-0375442chr1q31
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFH PAMR1 VCAN CFHR4

3.84e-06573441179
GeneFamilyGelsolin/villins

FLII VILL

9.54e-058342950
GeneFamilyComplement system|Sushi domain containing

CFH CFHR4

2.08e-0336342492
CoexpressionTRAVAGLINI_LUNG_MYOFIBROBLAST_CELL

CFH PDLIM3 PAMR1 VCAN

4.34e-0665444M41673
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_k-means-cluster#3_top-relative-expression-ranked_1000

PDLIM3 PAMR1 VILL ADAMTS9 VCAN NOTCH3

2.98e-05293446gudmap_kidney_P0_JuxtaGlom_Ren1_k3_1000
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIFBP TNFSF12 RCHY1 NOTCH3 THAP7

1.09e-06186445ed9b1a784f67e8a297e2a10993a6d97df60581ac
ToppCellASK428-Mesenchymal|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFH PDLIM3 PAMR1 VCAN NOTCH3

1.38e-061954452b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCellASK428-Mesenchymal-Fibroblast|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFH PDLIM3 PAMR1 VCAN NOTCH3

1.38e-06195445c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCelldistal-3-mesenchymal-Myofibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH GRIA3 PDLIM3 PAMR1 VCAN

1.52e-061994451f20addc0d138fec02ed6ca4c518169c568de263
ToppCelldistal-mesenchymal-Myofibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH GRIA3 PDLIM3 PAMR1 VCAN

1.56e-06200445069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCelldistal-mesenchymal-Myofibroblast|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH GRIA3 PDLIM3 PAMR1 VCAN

1.56e-0620044561854a459385cd9295be37157a8f81a2c227dff3
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH GRIA3 VCAN CFHR4

2.32e-05169444c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

2.43e-051714445d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellwk_08-11-Mesenchymal-Fibroblast-Airway_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SERTAD4 CFH PDLIM3 JMJD7

2.54e-05173444b23b408acc29a667cce104429afef1a6cf2720a5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

2.78e-051774449ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

2.78e-05177444016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.03e-05181444eea943fdcbef0bbaa8578f3296923e874893b405
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH WNT5B PDLIM3 VCAN

3.03e-051814445f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.03e-051814449c157de9d3403e092c907599f2a2c16db5b21131
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH WNT5B PDLIM3 VCAN

3.03e-05181444c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH WNT5B KAT5 VCAN

3.17e-0518344407ca2786e62eca9feecf5e54a11864a960f7641a
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.17e-05183444bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SERTAD4 CFH PAMR1 VCAN

3.23e-05184444d754c3de621429b220ae4ac426cdfc619e848462
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SERTAD4 CFH PDLIM3 KCNF1

3.30e-051854447dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYH9 PDLIM3 ADAMTS9 VCAN

3.30e-05185444e58a009aaf342be019a909747b1895d5987d4daf
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH PDLIM3 PAMR1 VCAN

3.37e-05186444f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SERTAD4 CFH PDLIM3 KCNF1

3.44e-051874445258674d0346e5c51a4b965efcdc1790c970845d
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

CFH WNT5B NOTCH3 FAM149A

3.44e-05187444ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellCOPD-Epithelial-Mesothelial|COPD / Disease state, Lineage and Cell class

CFH SLC28A3 PDLIM3 ADAMTS9

3.59e-0518944479bb2593ad5d17f94b17972884241f03a0f43770
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRIA3 PDLIM3 PAMR1 NOTCH3

3.59e-0518944445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFH WNT5B PAMR1 VCAN

3.67e-051904440fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

CFH PDLIM3 ADAMTS9 NOTCH3

3.74e-0519144478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell(5)_Epi_basal|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

SERTAD4 CFH PDLIM3 ADAMTS9

3.74e-051914446bda3d5a8a391d41bb4d65872492e6c094bcc4d4
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFH WNT5B PDLIM3 PAMR1

3.82e-051924448d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

CFH WNT5B PDLIM3 PAMR1

3.82e-05192444a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

3.90e-05193444dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

3.90e-05193444e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.98e-0519444491205b22650e7ecdb72bb59348ce2530b76c532c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

3.98e-0519444429f83cdd63314fff41258937d70b881a5503bfcc
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-mesenchymal_progenitor_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH PAMR1 TNFSF12 VCAN

3.98e-051944443d25d6ebec8d1b6001f602257cd15b3ba04cf0c1
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.98e-051944448fae8061b350336299aa81f378e07deadbd55123
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5B SLC28A3 PDLIM3 NOTCH3

3.98e-051944440ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

3.98e-05194444d3db241ea316bbcde6d16618193b474591ad5ce4
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH SLC28A3 PDLIM3 ADAMTS9

3.98e-05194444421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.98e-051944444d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.98e-051944446e12a7da35be4c0ecf998ef94b8989b89d74b200
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

3.98e-05194444c52f10140c66e8c0566421c3d535d5d92bf595e1
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH PAMR1 TNFSF12 VCAN

3.98e-05194444ff19fb5bc7feae3e774ef4ab720beb9dec219f45
ToppCell18-Distal-Mesenchymal-Mesenchyme_SERPINF1-high|Distal / Age, Tissue, Lineage and Cell class

SERTAD4 CFH PDLIM3 PAMR1

4.06e-05195444f86737bff21d81673238813df61a15cfe88d0b15
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5B SLC28A3 VILL NOTCH3

4.06e-0519544425703e3c2e0512ef12e7aa389fad3968c3f13905
ToppCellfacs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERTAD4 CFH TNFSF12 VCAN

4.06e-05195444690d6e15d7c863fc8f2d33b1f7bf86f019f415c9
ToppCellfacs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERTAD4 CFH TNFSF12 VCAN

4.06e-051954445c05e2bcea3d5d7ebe6325f7187ccf83301053d8
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH GRIA3 PDLIM3 PAMR1

4.22e-0519744416758f181ef07c60aee63072e1da9572c5c85414
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH PDLIM3 ADAMTS9 NOTCH3

4.22e-05197444cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CFH ADAMTS9 VCAN NOTCH3

4.22e-05197444b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PDLIM3 PAMR1 VCAN

4.22e-051974444cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CFH ADAMTS9 VCAN NOTCH3

4.22e-051974445afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CFH ADAMTS9 VCAN NOTCH3

4.22e-051974441baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH PDLIM3 ADAMTS9 NOTCH3

4.30e-05198444dc6d9032c5029527e184ac13b887c0c1f22ef1c0
ToppCellFibroblasts-DKK3+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SERTAD4 CFH PDLIM3 PAMR1

4.30e-051984444f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCelldistal-mesenchymal-Myofibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH PDLIM3 PAMR1 VCAN

4.30e-05198444beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCellSepsis-URO-Lymphocyte-T/NK-MAIT|URO / Disease, condition lineage and cell class

CFH IL18R1 DNAH14 SCN8A

4.30e-0519844475db638278d4be2b0f406cd8871058a8352c5a86
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CFH ADAMTS9 VCAN NOTCH3

4.39e-051994449b2262edbdec89166d895ab97527e0ee5f9b6010
ToppCelldistal-2-mesenchymal-Myofibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH GRIA3 PDLIM3 PAMR1

4.39e-05199444b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CFH ADAMTS9 VCAN NOTCH3

4.39e-05199444251b3643dcd8f4645b17101bd716e66f12a20e88
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CFH ADAMTS9 VCAN NOTCH3

4.39e-05199444117f4f43b6c06dda553799b1063e827bce697370
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MYH9 PDLIM3 ADAMTS9 NOTCH3

4.48e-052004442bc7f462a551292de2501028164573935232f899
ToppCellParenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH PDLIM3 ADAMTS9 NOTCH3

4.48e-0520044438190e4b32f7469df1da7d130bca6d7b12a3dd06
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH WNT5B SLC28A3 NOTCH3

4.48e-05200444b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCellcellseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH GRIA3 PDLIM3 PAMR1

4.48e-05200444b441b3771fb7d9ee7b7a104afc35e466aace2da2
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

GRIA3 PDLIM3 PAMR1 VCAN

4.48e-05200444a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH PDLIM3 PAMR1 VCAN

4.48e-0520044474e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

PDLIM3 PAMR1 VCAN NOTCH3

4.48e-052004445ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

CFH PDLIM3 PAMR1 ADAMTS9

4.48e-05200444c082bc21ec7c5323439d108ea8aea510e1113c3f
ToppCellBiopsy_Other_PF-Mesenchymal-PLIN2+_Fibroblasts|Biopsy_Other_PF / Sample group, Lineage and Cell type

CFH GRIA3 PDLIM3 PAMR1

4.48e-052004440aa316b71f195ecf17ee897e307f8928a755a637
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MYH9 PDLIM3 ADAMTS9 NOTCH3

4.48e-052004448b80a65b69b36ed405214564b939452c90aa40d6
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)|Thalamus / BrainAtlas - Mouse McCarroll V32

WNT5B PDLIM3 NOTCH3

2.61e-04126443333f83f9ba64d46f22fee328d0a691fd5818bdac
ToppCellThalamus-Endothelial-MURAL|Thalamus / BrainAtlas - Mouse McCarroll V32

WNT5B PDLIM3 NOTCH3

2.61e-04126443cf571f36761da3540fb445de89d555cbce8a47ab
ToppCellAT1-AT2_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

AATK PDLIM3 ADAMTS9

3.56e-0414044345d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 VILL KCNF1

4.18e-04148443f58804d24fe524b42b5090c8658050ea4b14793e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_CABP7|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFH ADAMTS9 CFHR4

5.06e-041584433fb5a5701a39824f7f23748709a3e0e1db551269
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 VILL KCNF1

5.16e-04159443c9e093d7c1dca83f6546adaf3d874929e2cea612
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACVR1 IL18R1 VCAN

5.25e-041604436215ac6123a295f3c2f033786602a57b2e2e1177
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

PDLIM3 ADAMTS9 NOTCH3

5.25e-04160443fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDLIM3 PAMR1 VCAN

5.25e-041604438624f101828efd32cdd38a65df8d94d690720a63
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDLIM3 PAMR1 VCAN

5.25e-041604439de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCellRV-13._Vascular_Smooth_Muscle|RV / Chamber and Cluster_Paper

PDLIM3 ADAMTS9 NOTCH3

5.35e-0416144347b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PAMR1 VILL KCNF1

5.35e-0416144366554f59eaea4ba55a6c6724f9368e24e99c91e9
ToppCelldroplet-Marrow-BM-30m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TESMIN TNFSF12 UBR4

5.45e-0416244375df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-5_LINC00507_SLN|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDLIM3 PAMR1 ADAMTS9

5.45e-04162443b59a0081e285cdf33de56e8b523fe0e446a198f1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH WNT5B AATK

5.54e-041634431feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDLIM3 IL18R1 NOTCH3

5.54e-041634431c014e373667be290d7fb5d24c06c6f313ac8fa3
ToppCellURO-Lymphocyte-T_NK-MAIT|URO / Disease, Lineage and Cell Type

CFH IL18R1 SCN8A

5.64e-04164443cb42a70433b3968caca67f7aa98ea536cd90a0bc
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

IL18R1 VCAN SCN8A

5.85e-0416644365dafed953b01a9830b54309af75c7a561e88336
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

CFH PAMR1 ADAMTS9

5.85e-041664431ed3788257e14f097862b999f020bfe2a57de52b
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH GRIA3 PDLIM3

5.95e-04167443a4a795751644b22af616335379e64ae95175180c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PAMR1 VCAN

6.05e-041684434b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH TNFSF12 ADAMTS9

6.05e-041684439930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCellPosterior_cortex-Endothelial-MURAL|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

WNT5B PDLIM3 NOTCH3

6.16e-041694430ae65daf092396b71f790b65c7a2feed90397417
ToppCellPosterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

WNT5B PDLIM3 NOTCH3

6.16e-041694438cd70ce27b1cecb83f8a376230e7ef41b079b124
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDLIM3 KCNF1 VCAN

6.16e-041694431c9e54e7b14eb99996590fb93b257cf881a9f184
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

CFH VILL VCAN

6.16e-041694436373562ab3b1765060212a6a53d6543e7e942e80
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NEK5 COPS5 ATXN7L3B

6.16e-0416944350cc0f5a022b95986949db63208a627cef9f4a69
ToppCellTCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

TRIM15 NEK5 FAM149A

6.26e-04170443d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNFSF12 IL18R1 NOTCH3

6.26e-04170443876b84740e15399bfff2b9c7f0b80fd759bbdb3f
Diseasec3d:C3 ratio

CFH CFHR4

2.07e-062432EFO_0008543
Diseasecalnexin measurement

CFH CFHR4

6.22e-063432EFO_0801444
Diseasecomplement factor H-related protein 4A measurement

CFH CFHR4

6.22e-063432EFO_0600057
Diseasehistone-lysine N-methyltransferase 2D measurement

CFH CFHR4

6.22e-063432EFO_0801683
DiseaseNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement

CFH CFHR4

1.24e-054432EFO_0803292
Diseasekallikrein-5 measurement

CFH CFHR4

1.24e-054432EFO_0020515
Diseasetumor necrosis factor ligand superfamily member 12 measurement

CFH TNFSF12

3.10e-056432EFO_0010801
Diseasecomplement C1s subcomponent measurement

CFH CFHR4

3.10e-056432EFO_0008091
Diseasecytoskeleton-associated protein 2 measurement

CFH MYH9

5.78e-058432EFO_0020309
DiseaseAtypical hemolytic-uremic syndrome

CFH CFHR4

7.42e-059432cv:C2931788
DiseaseHemolytic-uremic syndrome

CFH CFHR4

7.42e-059432cv:C0019061
Diseaseleukocyte immunoglobulin-like receptor subfamily A member 5 measurement

CFH CFHR4

7.42e-059432EFO_0801766
Diseasehemopexin measurement

CFH CFHR4

1.13e-0411432EFO_0008149
Diseaseobesity (implicated_via_orthology)

FLII KAT5 ADAMTS9 NOTCH3

2.71e-04215434DOID:9970 (implicated_via_orthology)
Diseasecoagulation factor measurement

CFH CFHR4

3.88e-0420432EFO_0004634
Diseasecomplement factor H-related protein 2 measurement

CFH CFHR4

8.21e-0429432EFO_0600055
DiseaseAge related macular degeneration

CFH CFHR4

8.79e-0430432C0242383
DiseaseComplement deficiency disease

CFH CFHR4

1.06e-0333432C0272242

Protein segments in the cluster

PeptideGeneStartEntry
TLKSGHYICDAYDFE

USP26

836

Q9BXU7
IEDFGVHCKQYYALE

COPS5

211

Q92905
VYCYVDHLDGDVFHL

VCAN

241

P13611
EVHRAVKCGYFYLEF

ATXN7L3B

36

Q96GX2
DGFHVYQKGCFQVYE

ACVR1

61

Q04771
KEEYGHSEVVEYYCN

CFH

646

P08603
ECGYKYRFFGEDAEI

MSH3

251

P20585
EFEDQGYYSCVHFLH

IL18R1

176

Q13478
EAFHGKFYEADCYIV

FLII

516

Q13045
VYHVDGKIEEYFAFD

FAM149A

401

A5PLN7
HYENLYCVVSGEKHF

JMJD7

181

P0C870
YEEAGSDFHQVAYFK

KIAA1109

3226

Q2LD37
FLFYVMTEYDCKGFH

KAT5

336

Q92993
MTEYDCKGFHIVGYF

KAT5

341

Q92993
YEGYCVDLAYEIAKH

GRIA3

451

P42263
FKEYECVKEHGDYTD

NEK5

616

Q6P3R8
YEKYCADHFADGRCD

NOTCH3

1471

Q9UM47
YQEEKCYEDGIFFYH

MEGF8

471

Q7Z7M0
VKDHYIFYCEGELHG

LCN1

111

P31025
ADFCIIHYAGKVDYK

MYH9

566

P35579
FEDHIDDAKYCGHLY

CNOT7

246

Q9UIV1
SEEEAELKHCFYKGY

ADAMTS9

141

Q9P2N4
IAGYFDIYFEKNCHN

PRMT3

451

O60678
FKLHDTLDYECYDGY

CFHR4

166

Q92496
EHVQDIFYGHCVDKY

DNAH14

3001

Q0VDD8
HEECVFPFTYKGSVY

ELSPBP1

26

Q96BH3
YEKSCVFPYDLYHAE

HELB

346

Q8NG08
HYVFEAKEFFQIDGY

KIFBP

401

Q96EK5
GTLDDFYVKGFYCAE

PAMR1

101

Q6UXH9
YEEDEFHVFKEAYLG

TESMIN

41

Q9Y4I5
DGEFYQFCYVTHKGE

TAX1BP1

96

Q86VP1
DYGLAHCKYREDYFV

AATK

271

Q6ZMQ8
GYFFIEGELYCETHA

PDLIM3

331

Q53GG5
IGYKTFFNEFVAYEH

SLC28A3

511

Q9HAS3
LAFECKGQFYDYFET

SERTAD4

306

Q9NUC0
PASEYIYFCSKHFEE

THAP7

56

Q9BT49
YYALGGHKDAIVACF

PWP2

181

Q15269
TYCEEHGEKIYFFCE

TRIM15

81

Q9C019
CGDNVEYGYRFAKEF

WNT5B

161

Q9H1J7
GKYHYCFNETSEIRF

SCN8A

1351

Q9UQD0
AYGNFFEEHCYVILH

VILL

31

O15195
HCDIYVKVFYAFSNA

ZNF429

146

Q86V71
YYLYCQVHFDEGKAV

TNFSF12

161

O43508
LFGEYYCDICHLFDK

RCHY1

81

Q96PM5
DHEISYAKYGSFFCD

UBR4

1701

Q5T4S7
FKCVIEVYYFGEVHM

KCNF1

86

Q9H3M0