Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin filament binding

NRAP MYO7A MYO9A CFL1 CFL2 SPTA1 NEB ARPC3 CTNNA2 PLEC

4.39e-0522718110GO:0051015
GeneOntologyMolecularFunctionphosphotyrosine residue binding

SH3BP2 PIK3R3 STAP1 PTPN6 PLCG2

9.70e-05511815GO:0001784
GeneOntologyMolecularFunctioncell adhesion molecule binding

DSG2 DSP OBSCN EXOC3 ITGAL GSK3B PTPN6 DST PTPRJ CTNNA2 BZW1 PLEC EPCAM FRMD5 CDH17

3.80e-0459918115GO:0050839
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

SH3BP2 PIK3R3 STAP1 PTPN6 PLCG2

4.07e-04691815GO:0045309
GeneOntologyMolecularFunctioncytoskeletal protein binding

NRAP KIF27 VEZT MYO7A MYO9A CFL1 CFL2 SPTA1 OBSCN GABARAPL2 NEB DYSF TUBGCP5 ARPC3 GSK3B TBCB DST MYLIP KCNQ2 CTNNA2 PLEC FRMD5

4.09e-04109918122GO:0008092
GeneOntologyBiologicalProcessresponse to interleukin-3

GSK3B JAK1 JAK2

2.34e-0571833GO:0036015
GeneOntologyBiologicalProcesscellular response to interleukin-3

GSK3B JAK1 JAK2

2.34e-0571833GO:0036016
GeneOntologyCellularComponentcell cortex

FLOT2 MYO7A CFL1 SPTA1 EXOC3 ITPR2 TBCB DST GUCY1B1 GPSM2 ASTN2 CTNNA2 EXOC2 NLRP4

4.60e-0637118114GO:0005938
GeneOntologyCellularComponentcell-cell junction

FLOT2 NRAP DSG2 VEZT DSP CFL1 OBSCN ITGAL PTPN6 DST PTPRJ ABI2 CTNNA2 ABCC2 EPCAM FRMD5 CDH17

1.59e-0559118117GO:0005911
GeneOntologyCellularComponentsecretory vesicle

DOCK2 FLOT2 DMXL2 ATP8B4 VEZT DSP WFS1 SRI EXOC3 LCN2 ITGAL DYSF F5 DNAJB3 ITPR2 CCT6A MYOF PTPN6 ATP11B AP2A1 PTPRJ UBE3A SLC6A5 C3 ATM KNG1

2.78e-05124618126GO:0099503
GeneOntologyCellularComponentZ disc

NRAP CFL2 SRI OBSCN DNAJB6 NEB DST PLEC

5.24e-051511818GO:0030018
GeneOntologyCellularComponentsecretory granule

DOCK2 FLOT2 DMXL2 ATP8B4 VEZT DSP WFS1 SRI EXOC3 LCN2 ITGAL F5 DNAJB3 ITPR2 CCT6A PTPN6 ATP11B AP2A1 PTPRJ SLC6A5 C3 KNG1

6.91e-05101418122GO:0030141
GeneOntologyCellularComponentI band

NRAP CFL2 SRI OBSCN DNAJB6 NEB DST PLEC

1.02e-041661818GO:0031674
GeneOntologyCellularComponentanchoring junction

FLOT2 NRAP DSG2 VEZT DSP CFL1 OBSCN ITGAL ARPC3 JAK1 JAK2 PTPN6 DST PTPRJ ABI2 CTNNA2 PLEC ABCC2 EPCAM FRMD5 CDH17

1.15e-0497618121GO:0070161
GeneOntologyCellularComponentcell-cell contact zone

FLOT2 NRAP DSG2 DSP OBSCN DST

1.68e-04941816GO:0044291
GeneOntologyCellularComponentintercalated disc

NRAP DSG2 DSP OBSCN DST

3.09e-04681815GO:0014704
GeneOntologyCellularComponentsarcomere

NRAP MYOM1 CFL2 SRI OBSCN DNAJB6 NEB DST PLEC

3.32e-042491819GO:0030017
GeneOntologyCellularComponentstriated muscle myosin thick filament

MYOM1 OBSCN

4.42e-0441812GO:0005863
GeneOntologyCellularComponentmyofibril

NRAP MYOM1 CFL2 SRI OBSCN DNAJB6 NEB DST PLEC

6.46e-042731819GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

NRAP MYOM1 CFL2 SRI OBSCN DNAJB6 NEB DST PLEC

9.89e-042901819GO:0043292
DomainSH2

SH3BP2 PIK3R3 STAP1 JAK1 JAK2 PTPN6 PLCG2 CLNK

1.13e-051101808SM00252
DomainSH2

SH3BP2 PIK3R3 STAP1 JAK1 JAK2 PTPN6 PLCG2 CLNK

1.21e-051111808PS50001
DomainSH2

SH3BP2 PIK3R3 STAP1 JAK1 JAK2 PTPN6 PLCG2 CLNK

1.29e-051121808IPR000980
Domain-

SH3BP2 PIK3R3 STAP1 JAK1 JAK2 PTPN6 PLCG2 CLNK

1.29e-0511218083.30.505.10
DomainPH_dom-like

PHLDB3 PSD2 MYO7A NBEAL1 SH3BP2 OBSCN DOCK10 DGKD STAP1 JAK1 JAK2 ELMO3 MYLIP PLCG2 FRMD5

1.69e-0542618015IPR011993
Domain-

DSP DST PLEC

1.72e-05618033.90.1290.10
DomainPlectin

DSP DST PLEC

2.99e-0571803PF00681
DomainPlectin_repeat

DSP DST PLEC

2.99e-0571803IPR001101
DomainPLEC

DSP DST PLEC

2.99e-0571803SM00250
DomainSH2

SH3BP2 PIK3R3 STAP1 JAK2 PTPN6 PLCG2 CLNK

5.51e-051011807PF00017
DomainDnaJ

DNAJC25 DNAJB6 DNAJB3 SEC63 DNAJB2

9.63e-05481805PF00226
DomainDNAJ_1

DNAJC25 DNAJB6 DNAJB3 SEC63 DNAJB2

1.06e-04491805PS00636
DomainDNAJ_2

DNAJC25 DNAJB6 DNAJB3 SEC63 DNAJB2

1.06e-04491805PS50076
DomainFERM_central

MYO7A JAK1 JAK2 MYLIP FRMD5

1.06e-04491805IPR019748
DomainFERM_domain

MYO7A JAK1 JAK2 MYLIP FRMD5

1.06e-04491805IPR000299
DomainDnaJ

DNAJC25 DNAJB6 DNAJB3 SEC63 DNAJB2

1.06e-04491805SM00271
Domain-

DNAJC25 DNAJB6 DNAJB3 SEC63 DNAJB2

1.06e-044918051.10.287.110
DomainFERM_1

MYO7A JAK1 JAK2 MYLIP FRMD5

1.17e-04501805PS00660
DomainFERM_2

MYO7A JAK1 JAK2 MYLIP FRMD5

1.17e-04501805PS00661
DomainFERM_3

MYO7A JAK1 JAK2 MYLIP FRMD5

1.17e-04501805PS50057
DomainBand_41_domain

MYO7A JAK1 JAK2 MYLIP FRMD5

1.17e-04501805IPR019749
DomainB41

MYO7A JAK1 JAK2 MYLIP FRMD5

1.17e-04501805SM00295
DomainDnaJ_domain

DNAJC25 DNAJB6 DNAJB3 SEC63 DNAJB2

1.29e-04511805IPR001623
DomainSpectrin_repeat

DSP SPTA1 DST PLEC

1.64e-04291804IPR002017
DomainSPEC

DSP SPTA1 DST PLEC

2.43e-04321804SM00150
DomainSpectrin/alpha-actinin

DSP SPTA1 DST PLEC

2.43e-04321804IPR018159
DomainFerA

DYSF MYOF

2.75e-0431802SM01200
DomainFerlin_A-domain

DYSF MYOF

2.75e-0431802IPR012560
DomainFerA

DYSF MYOF

2.75e-0431802PF08165
DomainADF/Cofilin

CFL1 CFL2

2.75e-0431802IPR017904
DomainSH3_domain

DOCK2 MYO7A SPTA1 OBSCN NEB DST MIA2 ABI2 PLCG2

2.91e-042201809IPR001452
Domain-

PHLDB3 PSD2 MYO7A SH3BP2 OBSCN DOCK10 DGKD STAP1 ELMO3 MYLIP PLCG2 FRMD5

4.24e-04391180122.30.29.30
DomainNebulin

NRAP NEB

5.47e-0441802PF00880
DomainNEBULIN

NRAP NEB

5.47e-0441802PS51216
DomainNEBU

NRAP NEB

5.47e-0441802SM00227
DomainDysFC

DYSF MYOF

5.47e-0441802SM00694
DomainDysFN

DYSF MYOF

5.47e-0441802SM00693
DomainNebulin

NRAP NEB

5.47e-0441802IPR013998
DomainNebulin_repeat

NRAP NEB

5.47e-0441802IPR000900
DomainTyr_kinase_non-rcpt_Jak/Tyk2

JAK1 JAK2

5.47e-0441802IPR016251
DomainPeroxin/Ferlin

DYSF MYOF

5.47e-0441802IPR006614
DomainFerI

DYSF MYOF

9.06e-0451802SM01202
DomainFerB

DYSF MYOF

9.06e-0451802SM01201
DomainFerlin_B-domain

DYSF MYOF

9.06e-0451802IPR012561
DomainFerlin_C

DYSF MYOF

9.06e-0451802PF16165
DomainFerlin_C

DYSF MYOF

9.06e-0451802IPR032362
DomainFerIin_dom

DYSF MYOF

9.06e-0451802IPR012968
DomainFerI

DYSF MYOF

9.06e-0451802PF08151
DomainFerB

DYSF MYOF

9.06e-0451802PF08150
DomainCu-oxidase_3

F5 HEPHL1

9.06e-0451802IPR011707
DomainMULTICOPPER_OXIDASE1

F5 HEPHL1

9.06e-0451802PS00079
DomainCu_oxidase_CS

F5 HEPHL1

9.06e-0451802IPR033138
DomainCu-oxidase_3

F5 HEPHL1

9.06e-0451802PF07732
DomainIQ

LRRIQ3 MYO7A MYO9A UBE3B OBSCN

1.12e-03811805SM00015
DomainSH3

DOCK2 MYO7A SPTA1 OBSCN NEB DST ABI2 PLCG2

1.20e-032161808PS50002
DomainCu_oxidase_Cu_BS

F5 HEPHL1

1.35e-0361802IPR002355
DomainRibosomal_S6_kinase_II

RPS6KA2 RPS6KA3

1.35e-0361802IPR016239
DomainPH

PHLDB3 PSD2 SH3BP2 OBSCN DOCK10 DGKD STAP1 ELMO3 PLCG2

1.54e-032781809SM00233
DomainPH_DOMAIN

PHLDB3 PSD2 SH3BP2 OBSCN DOCK10 DGKD STAP1 ELMO3 PLCG2

1.58e-032791809PS50003
DomainPH_domain

PHLDB3 PSD2 SH3BP2 OBSCN DOCK10 DGKD STAP1 ELMO3 PLCG2

1.62e-032801809IPR001849
DomainPH

PHLDB3 PSD2 SH3BP2 OBSCN DOCK10 DGKD STAP1 PLCG2

1.74e-032291808PF00169
DomainIQ_motif_EF-hand-BS

LRRIQ3 MYO7A MYO9A UBE3B OBSCN

1.78e-03901805IPR000048
DomainIQ

LRRIQ3 MYO7A MYO9A UBE3B OBSCN

2.06e-03931805PS50096
DomainHECT

UBE3B AREL1 UBE3A

2.17e-03271803PF00632
DomainHECTc

UBE3B AREL1 UBE3A

2.17e-03271803SM00119
DomainHECT_dom

UBE3B AREL1 UBE3A

2.17e-03271803IPR000569
DomainDnaJ_domain_CS

DNAJB6 DNAJB3 DNAJB2

2.17e-03271803IPR018253
DomainHECT

UBE3B AREL1 UBE3A

2.17e-03271803PS50237
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

FLOT2 RPS6KA2 RPS6KA3 ITPR2 PLCG2

2.47e-05361385M1315
PathwayREACTOME_RHO_GTPASE_CYCLE

DOCK2 FLOT2 DSG2 DSP MYO9A PIK3R3 PAK5 GPS1 OBSCN DOCK10 CPD ARHGAP5 CCT6A DST ABI2

2.59e-0543913815MM15595
PathwayREACTOME_RHO_GTPASE_CYCLE

DOCK2 FLOT2 DSG2 DSP MYO9A PIK3R3 PAK5 GPS1 OBSCN DOCK10 CPD ARHGAP5 CCT6A DST ABI2

3.45e-0545013815M27078
PathwayREACTOME_RND3_GTPASE_CYCLE

FLOT2 DSP CPD ARHGAP5 DST

5.32e-05421385M41826
PathwayREACTOME_RND1_GTPASE_CYCLE

FLOT2 DSP CPD ARHGAP5 DST

5.32e-05421385M41828
PathwayREACTOME_RND3_GTPASE_CYCLE

FLOT2 DSP CPD ARHGAP5 DST

5.32e-05421385MM15677
PathwayREACTOME_RND1_GTPASE_CYCLE

FLOT2 DSP CPD ARHGAP5 DST

5.97e-05431385MM15679
PathwayWP_EGFR1_SIGNALING_PATHWAY

RPS6KA2 RPS6KA3 PIK3R3 JAK1 JAK2 PTPN6 AP2A1 PLCG2 PLEC

9.63e-051881389MM15828
PathwayREACTOME_HEMOSTASIS

DOCK2 PDE1A KIF27 CFL1 PIK3R3 SRI DOCK10 DGKD APOB ITGAL F5 ITPR2 JAK2 PTPN6 GUCY1B1 PLCG2 EPCAM KNG1

1.11e-0467913818M8395
PathwayREACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING

PIK3R3 JAK1 JAK2 PTPN6

1.30e-04271384M921
PathwayREACTOME_HEMOSTASIS

DOCK2 PDE1A KIF27 PIK3R3 SRI DOCK10 DGKD APOB ITGAL F5 ITPR2 JAK2 PTPN6 PLCG2 EPCAM KNG1

1.46e-0457113816MM14472
PathwayREACTOME_PLATELET_HOMEOSTASIS

PDE1A SRI APOB ITPR2 PTPN6 GUCY1B1

1.95e-04861386M916
PathwayPID_P53_REGULATION_PATHWAY

KAT5 GSK3B CCNA2 CSNK1G1 ATM

2.74e-04591385M261
PathwayREACTOME_REGULATION_OF_IFNG_SIGNALING

JAK1 JAK2 PTPN6

3.09e-04141383M942
PathwayWP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY

FLOT2 CYP7A1 RPS6KA2 RPS6KA3 PIK3R3 GSK3B PRKAG1

3.15e-041321387M39338
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

DOCK2 CFL1 CFL2 PIK3R3 ARPC3 PLCG2

3.55e-04961386M16121
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DMXL2 ATRX DSP SRI DARS1 TUBGCP5 DCAF5 YARS1 EEF1A2 JAK1 ARHGAP5 SETDB1 MAN1A2 DST MIA2 AP2A1 GUCY1B1 UBE3A CTR9 KCNQ2 GPSM2 ASTN2 ATM EIF3D GFPT2 PLEC DNAJB2 AFF4

2.57e-1012851852835914814
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FLOT2 DMXL2 MYO7A DSP MYO9A WFS1 CFL1 CFL2 SPTA1 DNAJB6 DARS1 GABARAPL2 ARPC3 GSK3B YARS1 EEF1A2 ITPR2 ARHGAP5 CCT6A DST AP2A1 FAM120C XRN1 PLXNA4 KCNQ2 CTNNA2 PLEC TRAPPC9 KNG1

6.33e-1014311852937142655
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

ZNF148 VEZT WFS1 SLC26A2 SQLE PSMC4 GABARAPL2 CPD APOB ERGIC2 EEF1A2 TBCB JAK1 JAK2 MYOF TM9SF2 AP2A1 PTPRJ ATM CTNNA2 DNAJB2 EPCAM CDH17 ALG13

2.69e-0910611852433845483
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PHLDB3 IRF2BP1 ATRX MYO7A UBE3B GPS1 VPS50 PSMC4 EXOC3 LCN2 ARPC3 PGM3 CLASRP SETDB1 TM9SF2 AP2A1 CTR9 C3 EIF3D BZW1 EXOC2 PLEC TRAPPC9 TP53BP1 CCDC144A HSP90AB3P

9.75e-0913211852627173435
Pubmed

Defining the membrane proteome of NK cells.

DOCK2 FLOT2 GNL3L CFL1 VPS50 DNAJB6 DOCK10 PSMC4 DARS1 CPD ERGIC2 ITGAL F5 ARPC3 ITPR2 MAN1A2 MIA2 ATP11B AP2A1 XRN1 PRKAG1 EIF3D BZW1 EXOC2

1.70e-0811681852419946888
Pubmed

Functional proteomics mapping of a human signaling pathway.

ZNF484 IRF2BP1 ATRX SRI ASH2L ARHGAP5 SETDB1 PBRM1 MAN1A2 DST TM9SF2 AP2A1 UBE3A CTR9 PLCG2 PLEC DNAJB2

2.15e-085911851715231748
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

FLOT2 DSG2 DSP CFL1 SRI PSMC4 GABARAPL2 CPD APOB ERGIC2 GSK3B YARS1 JAK1 CCT6A MYOF DST TM9SF2 AP2A1 PDIA5 C3 ECEL1 CTNNA2 BZW1 SEC63 TP53BP1

2.90e-0812971852533545068
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

ATRX CFL2 RPS6KA2 RPS6KA3 PAK5 GSK3B CCNA2 ITPR2 JAK1 JAK2 MYOF DST AP2A1 CTR9 PRKAG1 MLLT1 PDIA5 EIF3D PLEC AFF4

9.92e-089101852036736316
Pubmed

Human transcription factor protein interaction networks.

FLOT2 ZNF148 KAT5 IRF2BP1 ATRX PSMC4 DARS1 ARPC3 ASH2L DCAF5 CCNA2 PRR12 FHAD1 CCT6A SETDB1 RBM12 PBRM1 DST XRN1 SUGP1 MLLT1 EIF3D GFPT2 TRAPPC9 TP53BP1

1.83e-0714291852535140242
Pubmed

Discovery and refinement of loci associated with lipid levels.

KAT5 CYP7A1 APOB ANGPTL1 GSK3B MYLIP SUGP1 C3 PLEC FRMD5

2.19e-072111851024097068
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

ATRX RPS6KA3 PSMC4 DARS1 EEF1A2 CCT6A SETDB1 PBRM1 CTR9 BZW1 PLEC TP53BP1

2.51e-073321851232786267
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

PHLDB3 GNL3L DSP MYO9A CFL1 DNAJB6 DOCK10 PSMC4 EXOC3 DGKD DARS1 GSK3B TBCB CCT6A DST AP2A1 UBE3A CTR9 XRN1 EIF3D PLCG2 EXOC2 PLEC TP53BP1

2.57e-0713531852429467282
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PCSK5 DMXL2 GNL3L ATRX UBE3B DOCK10 EXOC3 COLGALT2 ERGIC2 FHIP2A ASH2L PRR12 FREM2 DST CTR9 XRN1

4.61e-076501851638777146
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

DMXL2 NRAP MYOM1 DSP OBSCN DNAJB6 DGKD NEB DYSF ASH2L CCT6A DST MED12L PLEC

5.08e-074971851423414517
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

FLOT2 GNL3L ZNF148 KAT5 DSG2 VEZT SH3BP2 PIK3R3 VPS50 DNAJB6 TUBGCP5 DCAF5 JAK1 SETDB1 MLH3 PBRM1 FAM120C XRN1 MLLT1 AFF4 ALG13

5.99e-0711161852131753913
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

FLOT2 DMXL2 VEZT DSP WFS1 PSMC4 DARS1 ZDBF2 YARS1 TBCB CCT6A GUCY1B1 ABI2 UBE3A FAM120C XRN1 KCNQ2 CTNNA2 PLEC DNAJB2 TP53BP1

8.30e-0711391852136417873
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

GNL3L KAT5 ATRX DSG2 ARPC3 ASH2L TMX2 PRR12 CCT6A MYOF PBRM1 MAN1A2 DST ABI2 FAM120C ZBED6 CTR9 XRN1 MLLT1 EIF3D CTNNA2 EXOC2 SEC63 AFF4

1.54e-0614971852431527615
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MYO7A DSP OBSCN ESCO1 EEF1A2 ITPR2 JAK2 ARHGAP5 FREM2 LOXHD1 DST FAM120C PLXNA4 MLLT1 ATM EIF3D

2.32e-067361851629676528
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ATRX DSP CFL1 CFL2 SPTA1 GPS1 DNAJB6 APOB NEB DNAJB3 EEF1A2 TBCB CCT6A DST MIA2 AP2A1 CTR9 XRN1 PLXNA4 MLLT1 ATM PLEC ABCC2

2.82e-0614421852335575683
Pubmed

Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1.

JAK1 JAK2 PLCG2

2.93e-066185314978237
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

GNL3L MYO7A GPS1 VPS50 OBSCN PSMC4 EXOC3 AK9 NEB DYSF LOXHD1 ATM HYDIN

2.96e-064971851336774506
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

FLOT2 DMXL2 ZNF148 ATRX DSG2 VEZT WFS1 DNAJC25 PIK3R3 DNAJB6 PSMC4 EXOC3 CPD DNAJB3 DCAF5 EEF1A2 ITPR2 CTR9 PDIA5 ATM SEC63 DNAJB2 TP53BP1

4.68e-0614871852333957083
Pubmed

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.

PIK3R3 JAK1 JAK2

5.10e-06718539178903
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

FLOT2 DSG2 DSP MYO9A CFL1 DNAJB6 PSMC4 EXOC3 DARS1 CPD CCT6A DST XRN1 BZW1 SEC63

6.59e-067081851539231216
Pubmed

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

FLOT2 DSG2 SPTA1 OBSCN CCT6A EIF3D CTNNA2

6.89e-06131185728031328
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

DOCK2 DSP CFL1 SPTA1 PSMC4 DARS1 ARPC3 EEF1A2 CCT6A MYOF DST AP2A1 BZW1 PLEC HYDIN ALG13

7.39e-068071851630575818
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 PHLDB3 MYO7A CFL1 RPS6KA2 UBE3B OBSCN DYSF ITPR2 JAK2 PRR12 MYOF DST AP2A1 KCNQ2 MLLT1 PDIA5 PLEC TRAPPC9

7.73e-0611051851935748872
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

FLOT2 ATP8B4 GNL3L KIF27 ATRX DSG2 DSP CFL1 PSMC4 DARS1 APOB YARS1 CCT6A PBRM1 TM9SF2 AP2A1 CTR9 ATM EIF3D BZW1 SEC63 MGAM2

7.89e-0614251852230948266
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

ATRX SLC26A2 SQLE ZDBF2 TUBGCP5 ASH2L PGM3 CCNA2 TBCB CCT6A PBRM1 UBE3A CTR9 MYLIP XRN1 SUGP1 PRKAG1 ECEL1 BZW1 SNAPC2 SEC63

8.89e-0613271852132694731
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

SH3BP2 PIK3R3 JAK1 JAK2 PLCG2 CLNK

8.98e-0690185616273093
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

FLOT2 GNL3L IRF2BP1 CFL2 RPS6KA3 DNAJB6 PSMC4 FHIP2A ARPC3 PGM3 CCNA2 ITPR2 CCT6A MYOF DST ATM EIF3D CTNNA2 BZW1 EXOC2 SEC63 TRAPPC9

9.28e-0614401852230833792
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

DMXL2 DSP MYO9A CFL1 CFL2 SRI NEB TMX2 DST GFPT2

9.75e-063221851026514267
Pubmed

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

RPS6KA3 PIK3R3 DNAJB6 APOB PKDREJ EEF1A2 AP2A1 CTNNA2 DNAJB2

1.03e-05256185924189400
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

FLOT2 GNL3L ZNF148 ATRX DSG2 DSP CFL1 DARS1 EEF1A2 TBCB RBM12 DST XRN1 SUGP1 EIF3D AFF4 TP53BP1

1.15e-059341851733916271
Pubmed

P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.

RPS6KA2 RPS6KA3 GSK3B

1.21e-059185319555761
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

DSP DST PLEC

1.21e-059185312482924
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

PDE1A DSG2 VEZT DSP NBEAL1 ZDBF2 EEF1A2 TBCB DST XRN1 BZW1 SEC63 ALG13

1.24e-055681851337774976
Pubmed

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.

DSP F5 GSK3B C3 PLEC

1.24e-0556185537059927
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

FLOT2 DSG2 CFL2 DNAJB6 PSMC4 F5 ARPC3 MYOF DST AP2A1 CTR9 CSNK1G1 EIF3D PLEC

1.33e-056601851432780723
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

FLOT2 DSG2 DSP CFL1 CFL2 OBSCN PSMC4 DARS1 ARPC3 EEF1A2

1.34e-053341851030425250
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

FLOT2 GNL3L DSG2 DSP CFL1 CFL2 DNAJB6 DARS1 F5 ARPC3 YARS1 ITPR2 CCT6A MYOF DST AP2A1 C3 EIF3D PLEC SEC63

1.36e-0512571852036526897
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

GNL3L DSG2 DSP WFS1 CFL1 RPS6KA3 PSMC4 DARS1 APOB EEF1A2 ARHGAP5 PBRM1 FAM111A AP2A1 FAM120C CSNK1G1 PDIA5 CTNNA2 PLEC SEC63 AFF4

1.45e-0513711852136244648
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

FLOT2 DSG2 DARS1 JAK1 CCT6A MYOF TM9SF2 AP2A1 PLEC

1.48e-05268185933024031
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

KBTBD3 GNL3L ATRX VEZT MYO9A RPS6KA2 SH3BP2 PIK3R3 OBSCN CPD ESCO1 EEF1A2 JAK2 FAM111A ATP11B PTPRJ FAM120C PRKAG1 PDIA5 ASTN2 TRAPPC9 AFF4

1.56e-0514891852228611215
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DOCK2 KIF27 ATRX DSP PSMC4 CCT6A FAM120C MED12L PRKAG1 ATM BZW1 EXOC2 PLEC

1.60e-055821851320467437
Pubmed

Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.

KBTBD3 LCN2 MAN1A2 ATP11B BZW1

1.60e-0559185532031713
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

TRPA1 WFS1 PSMC4 APOB CCNA2 JAK1 CCT6A MYOF TM9SF2 AP2A1 UBE3A SEC63

1.66e-054991851222810586
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DMXL2 CFL1 RPS6KA2 PAK5 ARPC3 GSK3B EEF1A2 PBRM1 DST AP2A1 ABI2 UBE3A FAM120C KCNJ4 CTNNA2 AFF4 TP53BP1

1.71e-059631851728671696
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

DARS1 ARPC3 STAP1 YARS1 MYOF PTPN6 C3 PLCG2 PLEC TP53BP1

1.72e-053441851030333137
Pubmed

The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage.

CCNA2 ATM TP53BP1

1.73e-0510185327869164
Pubmed

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

FLOT2 PSMC4 CPD RNF217 DST

1.74e-0560185520682791
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

OBSCN ZDBF2 FHIP2A SEMA4G PLXNA4 MED12L

1.74e-05101185610997877
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

PHLDB3 FLOT2 DSG2 PIK3R3 EXOC3 CPD ARHGAP5 DST AP2A1 ABI2 SEC63

1.76e-054211851136976175
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ATRX DSP MYO9A VPS50 PSMC4 EXOC3 ZDBF2 GSK3B YARS1 SETDB1 CTR9 ZMYM6 TP53BP1

1.78e-055881851338580884
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

FLOT2 SLC26A2 CFL1 CFL2 SRI APOB LCN2 DYSF OGN ARPC3 CFHR3 CCT6A FREM2 MYOF PTPRJ C3 KNG1 HSP90AB3P

1.82e-0510701851823533145
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

ZNF148 DSG2 GPS1 LCN2 NEB TUBGCP5 CCNA2 ITPR2 DST CTR9 SERTAD4 C3 PLCG2 SNAPC2 PLEC EPCAM SLC38A6 HYDIN TP53BP1 ALG13

2.04e-0512931852015342556
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

OGFRL1 SCRN3 ATRX RPS6KA3 OBSCN APOB ASH2L DCAF5 E2F8 ARHGAP5 AREL1 CTR9 GFPT2 PLEC SEC63 NLRP4 AFF4 TP53BP1

2.15e-0510841851811544199
Pubmed

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.

TUBGCP5 ESCO1 FHAD1 FAM111A TRAPPC9

2.21e-0563185511572484
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

DSP DST PLEC

2.37e-0511185312802069
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

ATRX GSK3B MLH3 AP2A1 CTR9 SUGP1 MLLT1 AFF4

2.69e-05222185837071664
Pubmed

ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination.

ATM TP53BP1

2.81e-052185239083600
Pubmed

Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients.

JAK1 JAK2

2.81e-052185228645562
Pubmed

DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β.

GSK3B JAK2

2.81e-052185222087308
Pubmed

Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?

DSP GSK3B

2.81e-052185222898789
Pubmed

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

KAT5 ATM

2.81e-052185216141325
Pubmed

53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation.

ATM TP53BP1

2.81e-052185223858098
Pubmed

Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins.

JAK2 PTPN6

2.81e-05218529111009
Pubmed

The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.

JAK1 JAK2

2.81e-052185224158701
Pubmed

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.

JAK1 JAK2

2.81e-052185233827897
Pubmed

Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.

ATRX ATM

2.81e-052185229378238
Pubmed

Protein tyrosine phosphatase SHP-1 modulates osteoblast differentiation through direct association with and dephosphorylation of GSK3β.

GSK3B PTPN6

2.81e-052185227614023
Pubmed

TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.

TRPA1 ITPR2

2.81e-052185223761909
Pubmed

Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies.

JAK1 JAK2

2.81e-052185229508247
Pubmed

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1.

JAK2 PTPN6

2.81e-05218528943354
Pubmed

Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice.

JAK1 JAK2

2.81e-052185227222478
Pubmed

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.

JAK1 JAK2

2.81e-052185227903500
Pubmed

Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24.

JAK1 JAK2

2.81e-05218521581631
Pubmed

Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.

JAK1 JAK2

2.81e-052185219887489
Pubmed

Ionizing radiation can induce GSK-3beta phosphorylation and NF-kappaB transcriptional transactivation in ATM-deficient fibroblasts.

GSK3B ATM

2.81e-052185218243662
Pubmed

Molecular cloning, structure, and testis-specific expression of MFSJ1, a member of the DNAJ protein family, in the Japanese monkey (Macaca fuscata).

DNAJB6 DNAJB3

2.81e-052185212565881
Pubmed

Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180.

KAT5 PBRM1

2.81e-052185227461052
Pubmed

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

JAK1 JAK2

2.81e-052185222684105
Pubmed

Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b.

DYSF MYOF

2.81e-052185218495154
Pubmed

ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.

KAT5 ATM

2.81e-052185226420831
Pubmed

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit.

RPS6KA2 RPS6KA3

2.81e-052185211495723
Pubmed

The ADF/cofilin proteins: stimulus-responsive modulators of actin dynamics.

CFL1 CFL2

2.81e-05218528589446
Pubmed

RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity.

RPS6KA3 GSK3B

2.81e-052185224055036
Pubmed

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

JAK1 JAK2

2.81e-05218521848670
Pubmed

AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy.

DYSF PRKAG1

2.81e-052185232087766
Pubmed

Preclinical evaluation of JAK1/2 inhibition by ruxolitinib in a murine model of chronic graft-versus-host disease.

JAK1 JAK2

2.81e-052185233811972
Pubmed

Long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis.

JAK1 JAK2

2.81e-052185229263442
Pubmed

Structure of msj-1 gene in mice and humans: a possible role in the regulation of male reproduction.

DNAJB6 DNAJB3

2.81e-052185218184612
Pubmed

Cloning and characterization of a novel transcriptional repressor of the nicotinic acetylcholine receptor delta-subunit gene.

CHRND PTPN6

2.81e-05218528636158
Pubmed

Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy.

DSG2 GSK3B

2.81e-052185227170944
Pubmed

Malignant progressive tumor cell clone exhibits significant up-regulation of cofilin-2 and 27-kDa modified form of cofilin-1 compared to regressive clone.

CFL1 CFL2

2.81e-052185224023293
Pubmed

Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains.

DYSF MYOF

2.81e-052185211959863
Pubmed

53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.

ATM TP53BP1

2.81e-052185227613518
Pubmed

Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle.

DYSF MYOF

2.81e-052185234354129
Pubmed

Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14.

CFL1 CFL2

2.81e-05218528800436
Pubmed

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.

JAK1 JAK2

2.81e-052185224169825
InteractionTRIM66 interactions

FLOT2 GNL3L DSG2 VEZT PIK3R3 VPS50 TUBGCP5 JAK1 MLH3 FAM120C ALG13

3.01e-0620518411int:TRIM66
InteractionFGFR1 interactions

FLOT2 DSG2 VEZT CFL1 RPS6KA2 SH3BP2 RPS6KA3 OBSCN CPD JAK2 AP2A1 ABI2 SEL1L2 PLCG2 PLEC SEC63 EPCAM TRAPPC9 HSP90AB3P

5.61e-0663218419int:FGFR1
InteractionKCTD13 interactions

FLOT2 DMXL2 MYO7A DSP MYO9A WFS1 CFL1 CFL2 SPTA1 DNAJB6 DARS1 GABARAPL2 ARPC3 GSK3B YARS1 EEF1A2 ITPR2 ARHGAP5 CCT6A DST AP2A1 FAM120C XRN1 PLXNA4 KCNQ2 CTNNA2 GFPT2 PLEC TRAPPC9 KNG1

9.63e-06139418430int:KCTD13
InteractionAR interactions

FLOT2 ZNF148 KAT5 ATRX DSG2 DSP PIK3R3 PSMC4 ASH2L STAP1 GSK3B PRR12 CCT6A MLH3 RBM12 PBRM1 UBE3A CTR9 MYLIP SUGP1 MED12L PRKAG1 PLCG2 AFF4

1.28e-0599218424int:AR
InteractionISG15 interactions

FLOT2 DSG2 CFL1 DNAJB6 PSMC4 DARS1 IFIT2 EEF1A2 JAK1 CCT6A MYOF TM9SF2 AP2A1 FAM120C PLEC DNAJB2

1.28e-0549418416int:ISG15
InteractionLCK interactions

PHLDB3 FLOT2 DSG2 DSP SH3BP2 EXOC3 STAP1 YARS1 CCT6A PTPN6 DST AP2A1 UBE3A PLCG2 HSP90AB3P

2.41e-0546318415int:LCK
GeneFamilySH2 domain containing

SH3BP2 PIK3R3 STAP1 JAK2 PTPN6 PLCG2 CLNK

6.75e-061011267741
GeneFamilyEF-hand domain containing|Plakins

DSP DST PLEC

1.80e-0581263939
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

DNAJC25 DNAJB6 DNAJB3 SEC63 DNAJB2

2.26e-05491265584
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO7A JAK1 JAK2 MYLIP FRMD5

2.50e-055012651293
GeneFamilyFerlin family

DYSF MYOF

7.10e-0461262828
GeneFamilyAF4/FMR2 family|Super elongation complex

MLLT1 AFF4

1.68e-03912621280
GeneFamilyExocyst complex

EXOC3 EXOC2

1.68e-03912621055
GeneFamilyTudor domain containing

SETDB1 TP53BP1 ALG13

2.16e-03371263780
GeneFamilyMitogen-activated protein kinase-activated protein kinases

RPS6KA2 RPS6KA3

2.54e-031112621156
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

DOCK2 FLOT2 ZNF148 ATRX MYO7A SLC26A2 CFL1 RPS6KA3 DNAJB6 DOCK10 DARS1 ITGAL FHIP2A IL18R1 ARPC3 DCAF5 ITPR2 TBCB JAK1 PTPN6 RBM12 MAN1A2 FAM111A ATP11B PTPRJ UBE3A MYLIP XRN1 ATM BZW1

2.09e-07149218530M40023
CoexpressionGSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_UP

ATP8B4 PSD2 DOCK10 COLGALT2 IL18R1 ANGPTL1 TM9SF2 PTPRJ PLCG2 CLNK

2.32e-0716118510M9446
CoexpressionGSE27786_ERYTHROBLAST_VS_MONO_MAC_DN

OGFRL1 ATRX CFL1 RPS6KA3 IL18R1 SETDB1 MYOF ATP11B UBE3A SEC63

1.70e-0620018510M4878
CoexpressionHALLMARK_PI3K_AKT_MTOR_SIGNALING

CFL1 RPS6KA3 PIK3R3 ARPC3 GSK3B ITPR2 PRKAG1

9.90e-061051857M5923
CoexpressionGRUETZMANN_PANCREATIC_CANCER_UP

DOCK2 FLOT2 PDE1A SPTA1 SRI DGKD LCN2 CCNA2 TBCB PLCG2 BZW1 PLEC

1.02e-0535918512M15193
CoexpressionGSE3982_DC_VS_TH2_DN

DSG2 PSMC4 ITGAL IL18R1 STAP1 CCNA2 ARHGAP5 SLC6A5 GPSM2

1.27e-051991859M5486
CoexpressionGSE22886_CD8_VS_CD4_NAIVE_TCELL_UP

SLC26A2 RPS6KA3 DARS1 GABARAPL2 ERGIC2 IL18R1 AREL1 EXOC2 ZMYM6

1.32e-052001859M4402
CoexpressionNEWMAN_ERCC6_TARGETS_UP

PCSK5 SRI IFIT2 MYLIP

3.18e-05261854M5459
CoexpressionGSE26030_UNSTIM_VS_RESTIM_TH17_DAY15_POST_POLARIZATION_UP

PIK3R3 PSMC4 DARS1 ASH2L ATP11B CSNK1G1 SLC38A6 HYDIN

3.60e-051751858M8578
CoexpressionRODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP

OGFRL1 ATRX DSG2 VPS50 IFIT2 GSK3B YARS1 PGM3 ARHGAP5 CCT6A ATP11B XRN1 BZW1 PLEC FRMD5 AFF4

5.66e-0572118516M10237
CoexpressionGSE3720_UNSTIM_VS_LPS_STIM_VD1_GAMMADELTA_TCELL_DN

ATP8B4 DOCK10 ITGAL IL18R1 JAK1 XRN1 EXOC2

8.27e-051461857M6341
CoexpressionGSE24634_TEFF_VS_TCONV_DAY10_IN_CULTURE_UP

ATP8B4 RPS6KA3 F5 E2F8 CCNA2 CTR9 GPSM2 GFPT2

9.22e-052001858M4626
CoexpressionGSE28726_NAIVE_VS_ACTIVATED_VA24NEG_NKTCELL_UP

SQLE SRI EXOC3 F5 IL18R1 CCT6A MYOF PDIA5

9.22e-052001858M8322
CoexpressionGSE45365_NK_CELL_VS_CD11B_DC_MCMV_INFECTION_DN

ATP8B4 SPTA1 DOCK10 ITGAL TUBGCP5 IL18R1 PCDH11X CLNK

9.22e-052001858M9957
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_UP

OGFRL1 SCRN3 ATRX CFL2 RPS6KA3 ERGIC2 IFIT2 ESCO1 DCAF5 ARHGAP5 PBRM1 ABI2 BZW1

9.41e-0552318513M12707
CoexpressionLAKE_ADULT_KIDNEY_C20_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_A_CORTEX

PDE1A DSP ITPR2 PTPRJ ATP6V1C2 PLCG2 CLNK

1.06e-041521857M39239
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

DMXL2 KIF27 DSP MYO9A PIK3R3 VPS50 DNAJB6 DGKD DARS1 ESCO1 SETDB1 ATP11B SUGP1 MED12L GPSM2 ATM PLCG2 EPCAM NLRP4 ZMYM6 ALG13

7.88e-0682018221gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A DSG2 PAK5 DOCK10 STAP1 ITPR2 PTPRJ GPSM2 ATP6V1C2 PLCG2 CLNK

1.89e-10174185115f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A DSG2 PAK5 DOCK10 STAP1 ITPR2 LOXHD1 PTPRJ ATP6V1C2 PLCG2 CLNK

2.01e-101751851177c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP7A1 SPTA1 OBSCN APOB NEB FREM2 LOXHD1 PCDH11X KCNQ2 DNAH9 HYDIN

3.44e-10184185112cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP7A1 SPTA1 OBSCN APOB NEB FREM2 LOXHD1 PCDH11X KCNQ2 DNAH9 HYDIN

3.44e-10184185112b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP7A1 SPTA1 OBSCN APOB NEB FREM2 LOXHD1 PCDH11X KCNQ2 DNAH9 HYDIN

3.44e-1018418511ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF27 DSG2 SLC26A2 RPS6KA2 ZDBF2 FREM2 RBM12 PLXNA4 CCDC180 DNAH9 HYDIN

3.64e-101851851105bc89a566b0db90ae06506e067190a4739a0974
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A DSG2 PAK5 DOCK10 STAP1 LOXHD1 PTPRJ ATP6V1C2 PLCG2 CLNK

3.44e-091751851098947a226b5a2ac7091ff9d34243ea7736add973
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF148 ATRX DSG2 DSP NBEAL1 APOB ESCO1 ITPR2 ARHGAP5 CCT6A

7.97e-091911851060c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF148 ATRX DSG2 DSP NBEAL1 APOB ESCO1 ARHGAP5 CCT6A EPCAM

7.97e-091911851009db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF148 ATRX DSG2 DSP NBEAL1 APOB ESCO1 ITPR2 ARHGAP5 CCT6A

7.97e-0919118510973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

GNL3L ZNF148 ATRX NBEAL1 CPD GSK3B PBRM1 ATP11B ZBED6 CTR9

8.81e-0919318510abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX NEB OGN ANGPTL1 EEF1A2 ARHGAP5 COLEC12 CCT6A ZBED6 XRN1

9.72e-09195185105c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 LCN2 ITGAL F5 IL18R1 STAP1 MYOF C3 CCDC180

3.19e-081651859ab6ed7e30096c418e7be2d5eec33feeddd1387d9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 PAK5 STAP1 ITPR2 LOXHD1 PTPRJ ATP6V1C2 PLCG2 CLNK

5.56e-081761859c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 PAK5 STAP1 PTPRJ KCNQ2 ATP6V1C2 PLCG2 CLNK EPCAM

6.43e-08179185927ad6a609fe1f7532b142d0147bccf918704a6dd
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

PDE1A DSG2 PAK5 DOCK10 STAP1 ITPR2 PTPRJ ATP6V1C2 CLNK

7.77e-0818318595c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCellcritical-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDE1A ANGPTL1 STAP1 ITPR2 COLEC12 DST ATP6V1C2 PLCG2 CLNK

1.07e-07190185905a2c3549b68f49081723bf35db14974274419d5
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A DSG2 PAK5 ANGPTL1 STAP1 ATP6V1C2 PLCG2 CLNK EPCAM

1.07e-071901859bb3b396d78887d5d6f93a05c8ed4d703591bf33f
ToppCellControl-NK_CD56bright|Control / Disease condition and Cell class

OGFRL1 ATP8B4 IL18R1 STAP1 JAK1 DST PLXNA4 PLCG2 CLNK

1.22e-0719318598b1e7a226a6057e1097c1525984127b54e823876
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 COLGALT2 VIT OGN ANGPTL1 DST GPSM2 C3 GFPT2

1.34e-071951859f54bc4454270ff06e85596f98199372b50d0179f
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSG2 DSP CPD LCN2 TM9SF2 C3 BZW1 PLEC HYDIN

1.46e-0719718595c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DSP SQLE LCN2 PGM3 PCDH11X C3 ECEL1 CLNK EPCAM

1.66e-072001859e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAK5 DOCK10 STAP1 ITPR2 PTPRJ ATP6V1C2 PLCG2 CLNK

3.18e-071571858c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCellE18.5-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 ATP8B4 MYO7A SH3BP2 DOCK10 ITGAL PTPN6 PLCG2

4.04e-07162185860d3fe1f5cec4285b8774ff078ebcc6bfaec26ed
ToppCellE18.5-samps-Myeloid|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 ATP8B4 MYO7A SH3BP2 DOCK10 ITGAL PTPN6 PLCG2

4.04e-07162185818e4a807e25f754a69e9eaaddfde40f8de9b8512
ToppCellE18.5-samps-Myeloid-Macrophage|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 ATP8B4 MYO7A SH3BP2 DOCK10 ITGAL PTPN6 PLCG2

4.04e-0716218580970e4eda60e3f015335e2726e6d565fb2f43372
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

DOCK2 DMXL2 ATP8B4 NRAP MYOM1 OBSCN COLEC12 PTPRJ

5.83e-0717018584232fe937909f93d3736988c707b8f95ce993398
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 PAK5 DOCK10 STAP1 LOXHD1 ATP6V1C2 PLCG2 CLNK

7.58e-07176185825ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX MYO9A RPS6KA3 ESCO1 ARHGAP5 CCT6A ZBED6 XRN1

7.58e-071761858749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 ATP8B4 MYO7A SH3BP2 DOCK10 ITGAL PTPN6 FAM111A

7.58e-0717618586548797336c9f4ca0f38e74a2c629e2a4defa252
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 PAK5 STAP1 PTPRJ GPSM2 ATP6V1C2 PLCG2 CLNK

7.91e-0717718588e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZDBF2 ZNF112 E2F8 EEF1A2 FHAD1 MED12L KCNQ2 SLC38A6

7.91e-0717718588abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX NBEAL1 RPS6KA3 IFIT2 ARHGAP5 CCT6A ZBED6 XRN1

8.25e-07178185801dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 DOCK10 STAP1 ITPR2 LOXHD1 ATP6V1C2 PLCG2 CLNK

8.61e-071791858e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSP STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK EPCAM

9.36e-0718118586aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 DOCK10 STAP1 ITPR2 PTPRJ ATP6V1C2 PLCG2 CLNK

9.36e-07181185830729f0364f719c044712a51453e22dc2c1a232b
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSP STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK EPCAM

9.36e-07181185840df0afcb6848202da54670e84f22d7c3a515d01
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSP STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK EPCAM

9.36e-0718118582b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSP STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK EPCAM

9.36e-07181185840d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FLOT2 SCRN3 SH3BP2 PIK3R3 CCDC168 FHIP2A CLNK EPCAM

1.02e-0618318583cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCellMyeloid-B_(Activated_Macrophage)|World / shred on cell class and cell subclass (v4)

DMXL2 SH3BP2 DOCK10 ITGAL ITPR2 MYOF PTPN6 DST

1.15e-06186185833d731a7883d75e4e7db83b641cdb1e9a39938bf
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP8B4 SRI ANGPTL1 GPSM2 ATP6V1C2 PLCG2 CLNK EPCAM

1.15e-061861858c2b65b8345487710704c3eb043e9bef2e2b1ff27
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDE1A PAK5 STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK

1.40e-0619118588f4637e801554e2343b974fe7794f01dd2151418
ToppCelldroplet-Fat-Mat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PDE1A VIT OGN COLEC12 ASTN2 C3 GFPT2

1.51e-061931858ebd090d7801480b3cee45caac3d30cc991836769
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PDE1A VIT OGN COLEC12 ASTN2 C3 GFPT2

1.51e-06193185822c58032e58730715224d7934968ce92d150b0e8
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PDE1A VIT OGN COLEC12 ASTN2 C3 GFPT2

1.51e-061931858573ad2f848bede1fe20c7b4b352a9242ec294725
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF27 AK9 SAMD15 FHAD1 PLCG2 CCDC180 DNAH9 HYDIN

1.57e-0619418584a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 DSP ANGPTL1 STAP1 ITPR2 ATP6V1C2 PLCG2 CLNK

1.64e-061951858f7d9adadd37209ce1a38e5d621607b9c9270fed8
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 DMXL2 ATP8B4 SH3BP2 DOCK10 ITGAL DYSF PTPRJ

1.77e-061971858a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

KIF27 MYO7A AK9 SAMD15 FHAD1 CCDC180 DNAH9 HYDIN

1.83e-0619818586d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellControl_saline-Hematopoietic_Lymphocytic-Lymphocytic_NK/T-iNKT-MAIT|Control_saline / Treatment groups by lineage, cell group, cell type

DOCK2 ATP8B4 DOCK10 ITGAL IL18R1 JAK1 PTPN6 PLCG2

1.90e-0619918582d7ebb9642f6fe0afd5e3fdc711ded54b73acd11
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

OGFRL1 DSG2 NBEAL1 SLC26A2 PIK3R3 CPD MYOF C3

1.90e-0619918583d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

OGFRL1 DSG2 NBEAL1 SLC26A2 PIK3R3 CPD MYOF C3

1.90e-061991858262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellmild-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

OGFRL1 DMXL2 SH3BP2 JAK2 MYOF PTCH2 PLCG2 PLEC

1.98e-062001858934c2efc780318c66d667ca75be0de350361d351
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK2 ATP8B4 DOCK10 ITPR2 PTPRJ MED12L C3 KNG1

1.98e-062001858dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK2 ATP8B4 DOCK10 ITPR2 PTPRJ MED12L C3 KNG1

1.98e-06200185821bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK2 ATP8B4 DOCK10 ITPR2 PTPRJ MED12L C3 KNG1

1.98e-06200185833036d21c1c82109284473a515c4f890b33fdd5c
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK2 ATP8B4 DOCK10 ITPR2 PTPRJ MED12L C3 KNG1

1.98e-062001858a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK2 ATP8B4 DOCK10 ITPR2 PTPRJ MED12L C3 KNG1

1.98e-0620018583bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK2 ATP8B4 DOCK10 ITPR2 PTPRJ MED12L C3 KNG1

1.98e-062001858a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

OGFRL1 CCDC168 ITGAL ITPR2 PCDH11X ATM CCDC144A

3.18e-0615018576c39e73a0b05d4b26589f333ce13924e3d373b8d
ToppCellPND07-28-samps-Myeloid-Granulocyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

DOCK2 ITGAL STAP1 PTPN6 FAM111A PTPRJ PLCG2

4.12e-0615618575e1c5a7c9293b886920739cf766521df7f69726c
ToppCellPND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative|PND07-28-samps / Age Group, Lineage, Cell class and subclass

DOCK2 ITGAL STAP1 PTPN6 FAM111A PTPRJ PLCG2

4.12e-061561857166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 STAP1 ITPR2 PTPRJ ATP6V1C2 PLCG2 CLNK

4.87e-061601857174a4ab27114efcc63be36929b80680be3c35c9b
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NEB F5 FREM2 ABCC2 HEPHL1 DNAH9 HYDIN

5.28e-061621857bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell368C-Fibroblasts-Fibroblast-E|368C / Donor, Lineage, Cell class and subclass (all cells)

KBTBD3 KIF27 VIT RNF217 OGN E2F8 C3

5.28e-061621857e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell368C-Fibroblasts-Fibroblast-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

KBTBD3 KIF27 VIT RNF217 OGN E2F8 C3

5.28e-061621857ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8B4 MYO7A SH3BP2 DOCK10 ITGAL PTPN6 FAM111A

5.96e-0616518571dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 DSP ANGPTL1 STAP1 ATP6V1C2 PLCG2 CLNK

5.96e-061651857a6c6de17fec678ad0cac3138dde3a14cc39ffd26
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 DGKD ANGPTL1 STAP1 EEF1A2 PTPN6 PLCG2

6.71e-061681857063d0368d656962b335154c230bdcd9236e7c9ad
ToppCellControl-B_cells-Activated_B_cells|Control / group, cell type (main and fine annotations)

DOCK2 DOCK10 ANGPTL1 STAP1 ATM PLCG2 CLNK

6.71e-061681857a7159a35fe37f8c241cf8d391debe271e0698105
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 DGKD ANGPTL1 STAP1 EEF1A2 PTPN6 PLCG2

6.71e-061681857eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 DGKD ANGPTL1 STAP1 EEF1A2 PTPN6 PLCG2

6.71e-061681857a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCellileum|World / shred on tissue and cell subclass

DSP SLC26A2 APOB SLC3A1 DST ABCC2 CDH17

7.25e-0617018579f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8B4 SH3BP2 ITGAL F5 PTPN6 FAM111A MIA2

7.82e-061721857e72966ced5f2ee9e24ce9fd820d99a69a482a607
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8B4 SH3BP2 ITGAL F5 PTPN6 FAM111A MIA2

7.82e-06172185783730ea3b240b8e2f2a9fb6c34dd1408050867ff
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 DSP STAP1 ATP6V1C2 PLCG2 CLNK EPCAM

8.44e-061741857d81a5e767e8882ebca4678af881c94c062f8cea5
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 DGKD ANGPTL1 STAP1 EEF1A2 PTPN6 PLCG2

8.44e-0617418579eb3504f9340517ef5d056503044fbdb9ffeb714
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSG2 APOB SLC3A1 ARHGAP5 PLEC EPCAM CDH17

8.44e-0617418577c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCellLPS-antiTNF-Lymphocytic_B|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 DGKD ANGPTL1 STAP1 EEF1A2 PTPN6 PLCG2

8.44e-061741857cc493654ea3517bc6a145c7f787f304929636f86
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSG2 APOB SLC3A1 ARHGAP5 PLEC EPCAM CDH17

8.44e-0617418572fbdb62e269acf4447b171700a615e878dde7f9f
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 DGKD ANGPTL1 STAP1 EEF1A2 PTPN6 PLCG2

8.44e-061741857b4c2d1c029fcd0d4926aa79a5b789c713919dcf3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 STAP1 ITPR2 PTPRJ ATP6V1C2 PLCG2 CLNK

8.76e-0617518571d8da48236549c01381f777ce5b2937f9f86acc2
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

DMXL2 MYOM1 COLGALT2 IL18R1 DCAF5 PTPRJ PLXNA4

9.43e-06177185743e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCellCOVID-19_Mild-NK_CD56bright|COVID-19_Mild / Disease condition and Cell class

ATP8B4 MYO7A IL18R1 STAP1 DST PLXNA4 CLNK

1.01e-05179185790e7a4af195aa2332b07a9f06cde63e72ff49255
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANGPTL1 STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK

1.05e-0518018578af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCellCOVID-19-Epithelial-Ionocytes|Epithelial / Condition, Lineage and Cell class

PDE1A DOCK10 STAP1 ITPR2 ATP6V1C2 PLCG2 CLNK

1.09e-0518118574a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDE1A ANGPTL1 STAP1 COLEC12 DST ATP6V1C2 CLNK

1.17e-051831857ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF27 DSG2 VIT C3 CCDC180 DNAH9 HYDIN

1.21e-051841857264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF27 DSG2 VIT C3 CCDC180 DNAH9 HYDIN

1.21e-051841857d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF27 DSG2 VIT C3 CCDC180 DNAH9 HYDIN

1.21e-05184185722010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAK5 F5 STAP1 SLC6A5 ATP6V1C2 CLNK EPCAM

1.21e-05184185792314fcdb74c0a1262c9334c774819a2a49ba454
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK

1.30e-051861857a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 MYO7A SH3BP2 DOCK10 ITGAL MYOF DST

1.30e-0518618577950e03ea080238c168b9d807e217f459acdfb28
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FLOT2 SCRN3 PIK3R3 CCDC168 FHIP2A CLNK EPCAM

1.30e-051861857bca5215d406f1785bf3a420201d5686071fcaca5
ToppCellmoderate-Epithelial-Ionocyte|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ANGPTL1 STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK

1.35e-0518718573e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCellMyeloid-C_(Cd16+_Monocyte)|World / shred on cell class and cell subclass (v4)

DOCK2 ITGAL STAP1 PTPN6 PTPRJ PLCG2

1.39e-051251856c73a77340e79f73fd1f900724e82a94d82e6b1bf
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NEB STAP1 EEF1A2 ITPR2 ATP6V1C2 CLNK EPCAM

1.39e-0518818571f912ea015f50570e848259d948a0ba682d64bb4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DSG2 STAP1 ITPR2 DST ATP6V1C2 PLCG2 CLNK

1.39e-051881857e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCellCOVID-19-Epithelial-Ionocytes|COVID-19 / Condition, Lineage and Cell class

PDE1A DSP STAP1 FREM2 ATP6V1C2 CLNK EPCAM

1.39e-051881857a581cb9528d0febbf3addbb4f6bc140f91a584e6
Drug(1)-Nipecotic acid [498-95-3]; Down 200; 31uM; MCF7; HT_HG-U133A

FLOT2 IRF2BP1 ATRX SH3BP2 SRI MYOF NALF1 MIA2 ATP11B SUGP1 TRAPPC9

5.97e-07198182116500_DN
Drugalsterpaullone

CPD LCN2 GSK3B CCNA2 ATM

8.26e-06351825CID005005498
DrugCocaine

ZNF148 MYOM1 ATRX DSP RPS6KA3 OBSCN CAMK1G NEB SEMA4G GSK3B CCNA2 EEF1A2 JAK1 ARHGAP5 RBM12 NALF1 GUCY1B1 UBE3A KCNJ4 ATM EXOC2 SNAPC2 PLEC FRMD5 AFF4 CDH17

1.78e-05131418226ctd:D003042
DrugAzathymine, 6 [932-53-6]; Up 200; 31.4uM; MCF7; HT_HG-U133A

DMXL2 GNL3L VEZT MYO7A RPS6KA2 SH3BP2 SUGP1 ATM TRAPPC9

2.74e-0519418292827_UP
DrugAzapropazone [13539-59-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A

SQLE NEB DYSF SEMA4G JAK2 SUGP1 ASTN2 ATM ALG13

2.85e-0519518296522_DN
Drug5151277; Up 200; 14uM; MCF7; HT_HG-U133A_EA

GNL3L RPS6KA2 NEB DYSF ABI2 UBE3A CSNK1G1 SUGP1 GFPT2

2.85e-051951829903_UP
DrugEnoxacin [74011-58-8]; Up 200; 12.4uM; MCF7; HT_HG-U133A

PCSK5 DMXL2 TRPA1 MYO7A PAK5 F5 ITPR2 NALF1 KCNJ4

2.97e-0519618295251_UP
DrugPimozide [2062-78-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A

RPS6KA2 UBE3B VPS50 CPD NEB DYSF RBM12 SUGP1 SNAPC2

2.97e-0519618293178_DN
DrugSC 19220; Down 200; 10uM; MCF7; HT_HG-U133A

DMXL2 ATRX DSP SH3BP2 UBE3B NEB CCNA2 ARHGAP5 SUGP1

3.09e-0519718297060_DN
DrugCyclopentolate hydrochloride [5870-29-1]; Up 200; 12.2uM; MCF7; HT_HG-U133A

PDE1A IRF2BP1 RPS6KA2 SH3BP2 MYOF C3 CTNNA2 ABCC2 DNAH9

3.09e-0519718293555_UP
DrugLidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; PC3; HG-U133A

IRF2BP1 MYO9A EXOC3 IFIT2 SETDB1 SUGP1 PRKAG1 ATM DNAJB2

3.21e-0519818291917_UP
DrugTiletamine hydrochloride; Up 200; 15.4uM; HL60; HT_HG-U133A

TRPA1 PAK5 F5 SLC3A1 EEF1A2 MAN1A2 UBE3A FAM120C GFPT2

3.34e-0519918293137_UP
DrugScopolamine hydrochloride [55-16-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

GNL3L RPS6KA2 SRI JAK2 ARHGAP5 MIA2 ATM PLEC ZMYM6

3.34e-0519918294803_DN
Diseasedisease of cellular proliferation (implicated_via_orthology)

JAK1 JAK2 ATM

8.33e-0671853DOID:14566 (implicated_via_orthology)
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

MLH3 PTPRJ ATM EPCAM

2.01e-05261854C0009405
DiseaseBone Diseases, Developmental

PCSK5 SLC26A2 RPS6KA3 AFF4

2.34e-05271854C0005941
DiseaseHereditary non-polyposis colorectal cancer syndrome

MLH3 PTPRJ ATM EPCAM

2.34e-05271854C1112155
DiseaseHereditary Nonpolyposis Colorectal Cancer

MLH3 PTPRJ ATM EPCAM

3.14e-05291854C1333990
Diseasefactor XI measurement, venous thromboembolism

F5 PTPRJ PLCG2 KNG1

3.61e-05301854EFO_0004286, EFO_0004694
DiseaseBUDD-CHIARI SYNDROME

F5 JAK2

3.91e-0521852600880
DiseaseBudd-Chiari Syndrome

F5 JAK2

3.91e-0521852C0856761
DiseaseHepatic Vein Thrombosis

F5 JAK2

3.91e-0521852C0019154
DiseaseBudd-Chiari syndrome

F5 JAK2

3.91e-0521852cv:C0856761
Diseasesensorineural hearing loss (is_implicated_in)

MYO7A WFS1 F5 GPSM2

5.31e-05331854DOID:10003 (is_implicated_in)
Diseasefactor VIII measurement, venous thromboembolism

F5 PTPRJ PLCG2 KNG1

5.99e-05341854EFO_0004286, EFO_0004630
Diseasefatty acid measurement

KAT5 KIF27 CYP7A1 UBE3B DARS1 APOB ESCO1 PLXNA4 SUGP1 CTNNA2 TP53BP1

1.04e-0443618511EFO_0005110
DiseaseBudd-Chiari syndrome (is_implicated_in)

F5 JAK2

1.17e-0431852DOID:11512 (is_implicated_in)
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

MLH3 PTPRJ ATM

2.18e-04191853C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

MLH3 PTPRJ ATM

2.18e-04191853C2936783
DiseaseCoffin-Lowry syndrome (implicated_via_orthology)

RPS6KA2 RPS6KA3

2.33e-0441852DOID:3783 (implicated_via_orthology)
DiseaseCoughing

TRPA1 KNG1

2.33e-0441852C0010200
Diseasecancer (implicated_via_orthology)

KAT5 SQLE YARS1 PGM3 DST GPSM2 ATM HSP90AB3P

3.05e-042681858DOID:162 (implicated_via_orthology)
Diseasecomplement factor H-like 1 protein measurement

RNF217 FREM2 KCNQ2

3.42e-04221853EFO_0600092
DiseaseHeart valve disease

LCN2 JAK2 PTPN6

5.67e-04261853C0018824
DiseaseLimb-girdle muscular dystrophy

DNAJB6 DYSF PLEC

5.67e-04261853cv:C0686353
DiseaseMULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE

NEB CHRND

5.77e-0461852C1854678
Diseasetaurocholenate sulfate measurement

CYP7A1 ABCC2

5.77e-0461852EFO_0800277
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

CYP7A1 APOB RBM12 SUGP1 TP53BP1

6.88e-041111855EFO_0004530, EFO_0008595
Diseaselung small cell carcinoma (is_implicated_in)

ATRX PBRM1 ATM

7.08e-04281853DOID:5409 (is_implicated_in)
DiseaseArrhythmogenic right ventricular cardiomyopathy

DSG2 DSP

8.04e-0471852cv:C0349788
Diseasehereditary angioedema (is_implicated_in)

MYOF KNG1

8.04e-0471852DOID:14735 (is_implicated_in)
Diseaseepidermolysis bullosa simplex (is_implicated_in)

DST PLEC

8.04e-0471852DOID:4644 (is_implicated_in)
Diseaselimb-girdle muscular dystrophy (implicated_via_orthology)

DYSF MYOF

8.04e-0471852DOID:11724 (implicated_via_orthology)
Diseaseglycocholate measurement

NRAP DYSF TM9SF2

8.69e-04301853EFO_0010491
Diseaseglycoprotein measurement

APOB MIA2 SUGP1 HYDIN TP53BP1

9.41e-041191855EFO_0004555
Diseaseapolipoprotein B measurement

PCSK5 CYP7A1 APOB ZNF112 CLASRP MYOF CSNK1G1 MYLIP SUGP1 GPSM2 PLEC HYDIN

1.03e-0366318512EFO_0004615
DiseaseMuscular Dystrophies, Limb-Girdle

DNAJB6 DYSF PLEC

1.05e-03321853C0686353
DiseaseHuntington's disease (implicated_via_orthology)

DNAJB6 DNAJB3 DNAJB2

1.05e-03321853DOID:12858 (implicated_via_orthology)
DiseaseNemaline myopathy

CFL2 NEB

1.07e-0381852cv:C0206157
Diseaseatypical hemolytic-uremic syndrome (is_implicated_in)

CFHR3 C3

1.07e-0381852DOID:0080301 (is_implicated_in)
DiseasePolycythemia Vera

JAK1 JAK2

1.07e-0381852C0032463
DiseaseMalignant neoplasm of breast

CFL1 CFL2 RPS6KA3 OBSCN COLGALT2 DYSF PKDREJ CHRND CLASRP PBRM1 MIA2 SLC6A5 ASTN2 ATM DNAH9 TP53BP1

1.26e-03107418516C0006142
DiseaseNonsyndromic genetic hearing loss

MYO7A WFS1 LOXHD1 GPSM2

1.35e-03761854cv:C5680182
DiseaseLynch Syndrome

MLH3 EPCAM

1.37e-0391852C4552100
DiseaseAtypical hemolytic-uremic syndrome

CFHR3 C3

1.37e-0391852cv:C2931788
DiseaseHemolytic-uremic syndrome

CFHR3 C3

1.37e-0391852cv:C0019061
Diseaseendometrial cancer (is_implicated_in)

JAK1 MLH3 ATM

1.49e-03361853DOID:1380 (is_implicated_in)
Diseasemacrovascular complications of diabetes

RPS6KA2 F5

1.70e-03101852EFO_0010977
DiseaseAtypical Hemolytic Uremic Syndrome

CFHR3 C3

1.70e-03101852C2931788
Diseaselevel of Ceramide (d42:1) in blood serum

CYP7A1 SUGP1

1.70e-03101852OBA_2045187
Diseasevenous thromboembolism, factor VII measurement

F5 PTPRJ PLCG2

1.74e-03381853EFO_0004286, EFO_0004619
Diseaseaspartate aminotransferase measurement

KIF27 MYO7A SLC26A2 CFL2 OBSCN CFHR3 TMX2 SETDB1 PTPRJ SUGP1 ASTN2 CTNNA2 ABCC2 HEPHL1

1.77e-0390418514EFO_0004736
DiseaseEpilepsy, Cryptogenic

EEF1A2 UBE3A KCNQ2 ALG13

1.79e-03821854C0086237
DiseaseAwakening Epilepsy

EEF1A2 UBE3A KCNQ2 ALG13

1.79e-03821854C0751111
DiseaseAura

EEF1A2 UBE3A KCNQ2 ALG13

1.79e-03821854C0236018
Diseaselung non-small cell carcinoma (is_implicated_in)

JAK1 JAK2 PBRM1 ATM ABCC2

1.87e-031391855DOID:3908 (is_implicated_in)
Diseasecolon cancer (biomarker_via_orthology)

LCN2 GSK3B JAK2

1.88e-03391853DOID:219 (biomarker_via_orthology)
DiseaseHypercholesterolemia

CYP7A1 APOB STAP1

1.88e-03391853C0020443
Diseasenon-high density lipoprotein cholesterol measurement

PCSK5 CYP7A1 CFL2 SPTA1 RPS6KA3 APOB ERGIC2 PBRM1 MYLIP XRN1 SUGP1 HYDIN

1.90e-0371318512EFO_0005689
Diseasebipolar I disorder

RPS6KA2 EEF1A2 PBRM1 ASTN2 PLEC

2.00e-031411855EFO_0009963
Diseaselipoprotein-associated phospholipase A(2) measurement

APOB FRMD5 TP53BP1

2.02e-03401853EFO_0004746
DiseaseIntellectual Disability

FHIP2A PGM3 CCNA2 TMX2 PRR12 MED12L CTNNA2 ZMYM6 ALG13

2.14e-034471859C3714756
DiseaseTumoral calcinosis

LCN2 JAK2 PTPN6

2.33e-03421853C0263628
Diseasevenous thromboembolism, von Willebrand factor measurement

F5 PTPRJ PLCG2

2.33e-03421853EFO_0004286, EFO_0004629
DiseaseCalcinosis

LCN2 JAK2 PTPN6

2.33e-03421853C0006663
DiseaseMicrocalcification

LCN2 JAK2 PTPN6

2.33e-03421853C0521174
Diseaselevel of Ceramide (d42:2) in blood serum

CYP7A1 APOB

2.48e-03121852OBA_2045186
DiseaseThromboembolism

F5 JAK2

2.48e-03121852C0040038
Diseasetriglycerides in large LDL measurement

APOB SUGP1 TP53BP1

2.49e-03431853EFO_0022319
DiseaseNeoplasm Metastasis

CFL1 RPS6KA3 LCN2 OGN E2F8 TBCB

2.55e-032171856C0027627
Diseasesaturated fatty acids measurement

APOB SUGP1 TP53BP1

2.84e-03451853EFO_0022304
Diseasehematologic cancer (implicated_via_orthology)

JAK1 JAK2

2.91e-03131852DOID:2531 (implicated_via_orthology)
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

LCN2 C3

2.91e-03131852DOID:332 (biomarker_via_orthology)
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

IRF2BP1 CYP7A1 APOB MYLIP SUGP1 TP53BP1

2.98e-032241856EFO_0004574, EFO_0008317
Diseaseheart rate variability measurement, response to antipsychotic drug

COLGALT2 E2F8 ECEL1

3.02e-03461853EFO_0008003, GO_0097332
DiseaseAdenocarcinoma of large intestine

RPS6KA2 PAK5 MLH3 ATM

3.17e-03961854C1319315
DiseaseAutosomal recessive limb-girdle muscular dystrophy

DYSF PLEC

3.39e-03141852cv:C2931907
DiseaseGDH/6PGL endoplasmic bifunctional protein measurement

ERGIC2 SUGP1

3.39e-03141852EFO_0801619
Diseasehearing impairment

MYO7A WFS1 RPS6KA3 LOXHD1

3.42e-03981854C1384666
Diseasestatus epilepticus (biomarker_via_orthology)

CFL1 GSK3B ATM ABCC2

3.67e-031001854DOID:1824 (biomarker_via_orthology)
DiseaseAlzheimer disease

PDE1A ATP8B4 DSG2 NALF1 PCDH11X MED12L CTNNA2 PLCG2 PLEC

3.67e-034851859MONDO_0004975
DiseaseAcute kidney injury

LCN2 GSK3B C3 KNG1

3.81e-031011854C2609414
DiseasePsychotic Disorders

PAK5 RBM12 PBRM1 CDH17

3.81e-031011854C0033975
DiseaseAcute Kidney Insufficiency

LCN2 GSK3B C3 KNG1

3.81e-031011854C1565662
DiseaseKidney Failure, Acute

LCN2 GSK3B C3 KNG1

3.81e-031011854C0022660
Diseaseplatelet measurement

DOCK10 DCAF5 PBRM1 MED12L PDIA5 PLCG2 PLEC

3.86e-033151857EFO_0005036
Diseaselow density lipoprotein triglyceride measurement

APOB SUGP1

3.89e-03151852EFO_0009946
Diseaseschizophrenia (biomarker_via_orthology)

ASH2L GSK3B

3.89e-03151852DOID:5419 (biomarker_via_orthology)
Diseaseresponse to statin, LDL cholesterol change measurement

APOB MYLIP

3.89e-03151852EFO_0007804, GO_0036273
Diseasethrombosis (is_implicated_in)

F5 JAK2

3.89e-03151852DOID:0060903 (is_implicated_in)
Diseaseamenorrhea, response to antineoplastic agent

VPS50 APOB

3.89e-03151852EFO_0010269, GO_0097327
DiseaseSchizophrenia

GPS1 LCN2 IL18R1 GSK3B CCNA2 SETDB1 PTPN6 PBRM1 SLC6A5 KCNQ2 ASTN2 ATM CTNNA2

3.93e-0388318513C0036341
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

MYO7A LOXHD1 GPSM2

4.05e-03511853cv:CN043650
Diseasephospholipids in very small VLDL measurement

APOB SUGP1 TP53BP1

4.05e-03511853EFO_0022300
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

GSK3B ATM

4.43e-03161852C0334634
DiseaseAbnormal behavior

PRR12 MED12L

4.43e-03161852C0233514
Diseasesickle cell anemia (is_implicated_in)

APOB C3

4.43e-03161852DOID:10923 (is_implicated_in)
Diseasetriglycerides in HDL measurement

APOB SUGP1 TP53BP1

4.51e-03531853EFO_0022317
Diseasetriglycerides in medium HDL measurement

APOB SUGP1 TP53BP1

4.76e-03541853EFO_0022321
Diseasemelanoma

MYO7A FHIP2A SETDB1 ATM BZW1 CCDC63

4.89e-032481856C0025202
DiseaseEpilepsy

EEF1A2 UBE3A KCNQ2 ALG13

4.99e-031091854C0014544
DiseaseMAJOR AFFECTIVE DISORDER 2

KCNQ2 CDH17

5.00e-03171852C1839839
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

AK9 CHRND

5.00e-03171852C0751883

Protein segments in the cluster

PeptideGeneStartEntry
YEYTLGEEKFTFIEK

CCT6A

351

P40227
DVAYYFEKDVKGESL

EPCAM

211

P16422
LGYISKAEEYFLLKS

CHRND

381

Q07001
YSKFDVINLAAEKTY

PRKAG1

241

P54619
EGYYQKLSKAFVELT

PGM3

181

O95394
RYALYDATYETKESK

CFL1

81

P23528
FTLDVYRYKDSLKED

ALG13

56

Q9NP73
KYFTEAGLKELSEYV

BZW1

231

Q7L1Q6
KYEYEVDKDFSSKLR

ERGIC2

61

Q96RQ1
DVYDKVDYLSSLGKT

FLOT2

156

Q14254
KDSKFYLEGEVLFVS

SH3BP2

516

P78314
LKVAILAEKYAVDYS

AP2A1

426

O95782
DRYISKYELDKAFSD

C3

1426

P01024
DKKVYAEYSSFRLEP

ANGPTL1

376

O95841
LAIAYRDLDDKYFKE

ATP8B4

596

Q8TF62
FVYSKSDALLSKDRY

DMXL2

1146

Q8TDJ6
EARDAVYLKYLASFE

CCDC180

1651

Q9P1Z9
VYLKYLASFEEELKR

CCDC180

1656

Q9P1Z9
KKVDEYTDTDLYTGE

ASTN2

1106

O75129
SYLEKVVAIYDYTKD

ABI2

451

Q9NYB9
ALSDRFEKAVYYLDA

AFF4

931

Q9UHB7
SYLYFEEKDFVDKAE

ASH2L

516

Q9UBL3
EDFIYKHRKALESEY

NBEAL1

2196

Q6ZS30
KKLDIVEDSIYIAYG

RBM12

451

Q9NTZ6
DFGLTKAIETDKEYY

JAK1

1021

P23458
GVVLYELFTYIEKSK

JAK2

1041

O60674
AKEGTKADLEVLTYY

ITPR2

716

Q14571
FLDYAYTGKTKITDD

KBTBD3

106

Q8NAB2
VVFEEKSHYKVDYSR

KCNJ4

321

P48050
DLAEERGLKITYKYT

DSG2

76

Q14126
YTTEKYREKSLYGDD

PAK5

141

Q9P286
YADKEETKLKGVIYF

PHLDB3

566

Q6NSJ2
VLKYTYEDFKKGASD

PTPRJ

866

Q12913
FYAKELTTYEIEEFK

OGFRL1

171

Q5TC84
RFSLSAKVVDDEIYY

PBRM1

1276

Q86U86
DGKTYDAFVSYLKEC

IL18R1

371

Q13478
GEFETASEYYKKTLL

GPSM2

256

P81274
LSKKEDVFAYLAKYS

MED12L

136

Q86YW9
KDAVTEKKYILYDFS

MGAM2

811

Q2M2H8
SGEIISDYKYKEAFE

NRAP

1056

Q86VF7
IFYKLLADGYSEKIE

DST

3281

Q03001
VLTEAGDYTEKYLKL

GLB1L3

371

Q8NCI6
EEDDSKEYGEFYKSL

HSP90AB3P

236

Q58FF7
IITLKDVYDDGKYVY

RPS6KA3

476

P51812
YLRTLFTDLFEKKGY

CSNK1G1

306

Q9HCP0
ISFEKEYYLVNEDSK

FREM2

1771

Q5SZK8
IVGYFSKEKESTEDY

KAT5

351

Q92993
YGKLLIEFSYELSKV

KAT5

381

Q92993
DSRVYIKLYGDKSDT

LOXHD1

701

Q8IVV2
RYALYDATYETKESK

CFL2

81

Q9Y281
LEKDLYFYKKTSRDH

KIF27

1206

Q86VH2
TVYRKFKYGLLDDDD

PCSK5

1831

Q92824
SEIFSYVGKYSEEIL

PLXNA4

1851

Q9HCM2
FKKYYAEVETRIEAL

EXOC2

321

Q96KP1
KEYEKSSEGALYILE

KCNQ2

116

O43526
ISFKYKEFELSGYIS

MLH3

226

Q9UHC1
ITFAEALEVGYSKYK

PDE1A

201

P54750
DKCYYFSVEKEIFED

COLEC12

616

Q5KU26
VRDIIFKFYESKYAS

GPS1

326

Q13098
SDIESVERKIYKAYK

DCAF5

651

Q96JK2
YVFDIKRTSKEVYDH

MYLIP

311

Q8WY64
SIFSQDYEDKYLDGK

OGN

41

P20774
YDFYTSIFDKIREKE

TUBGCP5

736

Q96RT8
FIETGKVKFSIYLEY

ABCC2

956

Q92887
IIYDDSKTYDLVAAA

GUCY1B1

41

Q02153
KILLKYGERESSYVF

NLRP4

436

Q96MN2
ALYDYKAKRSDELSF

PLCG2

776

P16885
AAYLDYESTKEYAIK

PCDH11X

421

Q9BZA7
FDREKQESYTFYVKA

PCDH11X

631

Q9BZA7
AVDKEYEFEVHEKTY

ECEL1

521

O95672
KLFEKIKEGYYEFES

CAMK1G

226

Q96NX5
VSTAIQEFYKKYAEE

OBSCN

5796

Q5VST9
EYFKITLYGRTKELT

LCN2

151

P80188
KSKEYDRLYEEYTRT

PIK3R3

191

Q92569
TAYETLKDEETRKDY

DNAJC25

106

Q9H1X3
FEGKTFYLYVSQKEE

FRMD5

251

Q7Z6J6
EAYEVLSDAKKRDIY

DNAJB6

51

O75190
STFYESLKYARVKEV

ATM

2141

Q13315
LSDYYEKFIAESKRL

APOB

4506

P04114
LDYISKENKGYFDED

ATRX

1891

P46100
SDRKYYAKTGDTIEF

CFHR3

286

Q02985
EVSRLSDYEIESKYK

FHAD1

236

B1AJZ9
LDYIDVLSGSKKDYK

HYDIN

4781

Q4G0P3
YESKYGEVSKTLDLL

CCDC63

396

Q8NA47
EKQRDFKKLSDLYYD

DOCK10

1841

Q96BY6
KKEYEQEFDFIKSYS

E2F8

211

A0AVK6
LKETLYETIIGYFDK

DOCK2

1276

Q92608
YEAGVYTEKVLEATK

CTNNA2

561

P26232
YKDLRKFLESKGYEF

GFPT2

126

O94808
TKDTDIVDEAIYYFK

ARPC3

36

O15145
EAYEVLSDAKKRDIY

DNAJB3

51

Q8WWF6
EAYEVLSDKHKREIY

DNAJB2

51

P25686
AYSEKRYDEIVKEVS

EEF1A2

161

Q05639
TFGYEELKDKETNYF

FAM111A

411

Q96PZ2
YYDKAFDRITTRSEK

EIF3D

201

O15371
EAYKKGLIDYETFKE

DSP

2481

P15924
DKIERFKKAVEYYSV

FAM120C

391

Q9NX05
LYDDAAIFEAKKSFY

SQLE

441

Q14534
FYSSGEKKDEVYLNL

GSK3B

116

P49841
ALALEYYKQGKTEEF

CTR9

46

Q6PD62
TGIYSKTSDDEVFKY

CPD

276

O75976
KTSDDEVFKYLAKAY

CPD

281

O75976
KYFETDDPEFYKSKV

AREL1

596

O15033
KDLYELAFSISYDRG

ELMO3

621

Q96BJ8
SFLFKIDKSYREDVY

HEPHL1

1011

Q6MZM0
EDAEYYFQKEFSKEL

IFIT2

351

P09913
LAAYYLSGEEIFKIK

MAN1A2

276

O60476
TLYYAKTAKSIIFDE

DGKD

81

Q16760
VGSDTFYSFKYEIKE

KNG1

66

P01042
TFKYDRYLDENGKTK

CYP7A1

406

P22680
IYGSYLSKEEIAFSD

ESCO1

796

Q5FWF5
TIFDYYIDPETKKFE

DNAH9

2416

Q9NYC9
EYESRSYTLEFIGKK

CCDC168

2136

Q8NDH2
LKKGTYDKAYTDELV

MLLT1

486

Q03111
KAITHYYIETSDDKA

FHIP2A

31

Q5W0V3
ADFNKTELERYKELY

CCDC144A

1266

A2RUR9
AEFVYITDDTYTKKQ

CCNA2

276

P20248
FLSRYKDEAQLYKEE

EXOC3

461

O60645
AEYKEYYESRDLKAF

COLGALT2

536

Q8IYK4
EEKDAYVFYAVAKDE

CDH17

301

Q12864
LSDKFRKEYYALGSL

SAMD15

451

Q9P1V8
CGSYLEKDFDTLKVY

DYSF

1491

O75923
EKEKDEDGFLYVAYS

GABARAPL2

96

P60520
KALASSGFKYLEYER

IRF2BP1

306

Q8IU81
YGKFAEKYDSDRTEL

PDIA5

481

Q14554
LEKFSLVQKEYEGYE

MIA2

701

Q96PC5
IYYFSSAEAKEKFLE

AK9

961

Q5TCS8
KENKFTVREFYYDEK

ATP6V1C2

241

Q8NEY4
NKTYTAYVDLEKDFA

YARS1

286

P54577
RYIVLAKDFEKAYKT

PSMC4

391

P43686
SEEYFKYFVLKISAG

SLC6A5

371

Q9Y345
LSVTSFKKIVYREYE

F5

56

P12259
EDTTYKKVVFRKYLD

F5

1611

P12259
EVALSYYKKVADYIA

SEL1L2

236

Q5TEA6
KKEFDFAAAYSYLDT

SCRN3

216

Q0VDG4
DFDRKASAEIYLYVA

PKDREJ

1956

Q9NTG1
DDEATRKAYYKEFRK

GNL3L

116

Q9NVN8
ELHYTKEKLGEEAAY

PTCH2

96

Q9Y6C5
YYTSVEIYGLDSVKK

GMCL2

216

Q8NEA9
LFGYLTFYDKVESEL

SLC38A6

301

Q8IZM9
TFYDKVESELLKGYS

SLC38A6

306

Q8IZM9
YKSSLKDFRYGVEDF

SLC3A1

166

Q07837
LGHLVKEKYDTDFYI

DARS1

376

P14868
EAYKYITEADSKEVY

ARHGAP5

461

Q13017
DTIFKQKGYSDEIYV

ARHGAP5

1096

Q13017
DSIKYKYFLELGRID

RNF217

326

Q8TC41
SYKTEFDFSDYVKRK

ITGAL

201

P20701
QEFKVELEKSGYYTL

PRR12

1956

Q9ULL5
TSKITYFKRKYVEEE

SERTAD4

71

Q9NUC0
VKDFYSKLGLQYRDS

SETDB1

96

Q15047
IKESEYADTHYFKVA

CLNK

91

Q7Z7G1
LAEKKASIGYTYEDS

CLASRP

156

Q8N2M8
AYRKFTSKEYEEIDK

ATP11B

631

Q9Y2G3
DYSEYKEFKLTVENI

SUGP1

551

Q8IWZ8
YFSVDSFDIVKYELE

VPS50

61

Q96JG6
EYIKYFNDKTIDEEL

TMX2

136

Q9Y320
DFKESLKVVFEGSAY

TRPA1

31

O75762
DFKDVTYLTEEKVYE

UBE3A

121

Q05086
EFLFTLYSAGEEKEK

TRAV20

66

A0A0B4J274
ESKASAVGDDDKVYY

SEMA4G

226

Q9NTN9
KKEEENLLFYSVYEA

SLC26A2

701

P50443
AEEYRLKEHYLTFEK

PSD2

691

Q9BQI7
FYTDKKSIIYVDKLD

STAP1

56

Q9ULZ2
LYGVDDKFYSKLDQE

TBCB

56

Q99426
EYIDYEFSVLKEKIT

XRN1

256

Q8IZH2
IYLEDKSYKLGDFDV

ZDBF2

1396

Q9HCK1
YEQRLEFGFDKYSSK

VIT

541

Q6UXI7
FLFLAYKVSKTDREY

SEC63

86

Q9UGP8
KGYVSLEDYTAFLID

SPTA1

2331

P02549
HRKESGELYYSIEKE

TP53BP1

1561

Q12888
GIYLEDTKEKVSIYE

PLEC

3496

Q15149
GEKFATLTELVEYYT

PTPN6

66

P29350
EEKLYTDIEYGKSFI

ZNF112

411

Q9UJU3
FYKNLTSIKRYDGDI

UBE3B

826

Q7Z3V4
VVDEYFKEKYSEFSG

ZBED6

866

P86452
KIAYTYSVSFEEDDK

TM9SF2

266

Q99805
KRLGFFQTYDTEYLK

ZMYM6

736

O95789
YAGICTEYEKDFSLK

ZNF484

301

Q5JVG2
EDIIDKYKEAISYYS

TRAPPC9

321

Q96Q05
TYEESKVSKYAFELV

ZNF148

416

Q9UQR1
FRKDDFYYLSQEDKE

VEZT

556

Q9HBM0
DFAVDFEKIYKYLSS

SNAPC2

201

Q13487
KRYSTNGKITFDDYI

SRI

146

P30626
YIALDDFVEITKKYA

WFS1

241

O76024
TLKDVYDDGKFVYLV

RPS6KA2

471

Q15349
KLRTFSDIDKYYTEQ

LRRIQ3

416

A6PVS8
QEKYEEFESVLHKYL

NALF1

276

B1AL88
IYRVKFEEDKSYFPS

MYO7A

2041

Q13402
DGKSIRYKDLYALFE

MYO9A

1916

B2RTY4
KDLKISVYDYDTFTR

MYOF

1616

Q9NZM1
ESKDAKELVGYYIEA

MYOM1

761

P52179
EYRKDYEKSKTIYTA

NEB

881

P20929
KASRDVISDYKYKDG

NEB

3026

P20929
YVGDITSDIKYKEDL

NEB

5081

P20929
YKEVFERTKSDFKYV

NEB

5371

P20929