Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	HS3ST4 HS3ST3B1 HS3ST3A1	2.39e-06	7	83	3	GO:0008467
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity	HS3ST3B1 HS3ST3A1	1.71e-05	2	83	2	GO:0033872
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	HS3ST4 HS3ST3B1 HS3ST3A1	3.04e-05	15	83	3	GO:0034483
GeneOntologyMolecularFunction	microfibril binding	VWA1 ADAMTSL2	2.53e-04	6	83	2	GO:0050436
GeneOntologyMolecularFunction	endopeptidase activity	TPP2 RHBDF2 HTRA2 PCSK7 ASPRV1 ESPL1 ECE2 ADAMTSL2	4.17e-04	430	83	8	GO:0004175
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan metabolic process	NAGLU HS3ST4 HS3ST3B1 HS3ST3A1	5.31e-07	17	82	4	GO:0030201
GeneOntologyBiologicalProcess	cortical actin cytoskeleton organization	LLGL2 TLN1 TNF PLEC	3.05e-05	45	82	4	GO:0030866
Domain	DUF2075	SLFN13 SLFN11	6.12e-05	3	85	2	IPR018647
Domain	DUF2075	SLFN13 SLFN11	6.12e-05	3	85	2	PF09848
Domain	AlbA_2	SLFN13 SLFN11	4.24e-04	7	85	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	4.24e-04	7	85	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	4.24e-04	7	85	2	IPR007421
Domain	Sulfotransferase_dom	HS3ST4 HS3ST3B1 HS3ST3A1	5.83e-04	36	85	3	IPR000863
Domain	Sulfotransfer_1	HS3ST4 HS3ST3B1 HS3ST3A1	5.83e-04	36	85	3	PF00685
Domain	Peptidase_S8_His-AS	TPP2 PCSK7	7.22e-04	9	85	2	IPR022398
Domain	Peptidase_S8_Ser-AS	TPP2 PCSK7	7.22e-04	9	85	2	IPR023828
Domain	Peptidase_S8_subtilisin-rel	TPP2 PCSK7	9.00e-04	10	85	2	IPR015500
Domain	SUBTILASE_ASP	TPP2 PCSK7	9.00e-04	10	85	2	PS00136
Domain	SUBTILASE_HIS	TPP2 PCSK7	9.00e-04	10	85	2	PS00137
Domain	SUBTILASE_SER	TPP2 PCSK7	9.00e-04	10	85	2	PS00138
Domain	-	TPP2 PCSK7	1.10e-03	11	85	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	TPP2 PCSK7	1.10e-03	11	85	2	IPR000209
Domain	Peptidase_S8	TPP2 PCSK7	1.10e-03	11	85	2	PF00082
Domain	Kelch_2	LZTR1 LCMT2	1.55e-03	13	85	2	IPR011498
Domain	Kelch_2	LZTR1 LCMT2	1.55e-03	13	85	2	PF07646
Domain	Methyltransf_11	PRMT6 ECE2	2.36e-03	16	85	2	PF08241
Domain	Methyltransf_11	PRMT6 ECE2	2.36e-03	16	85	2	IPR013216
Domain	LH2	PKD1 ALOX12B	2.99e-03	18	85	2	SM00308
Domain	-	EPHX2 PITPNM3 PGP	3.10e-03	64	85	3	3.40.50.1000
Domain	CH	EHBP1L1 CAMSAP3 PLEC	4.00e-03	70	85	3	PF00307
Domain	PLAT	PKD1 ALOX12B	4.06e-03	21	85	2	PS50095
Domain	-	PKD1 ALOX12B	4.06e-03	21	85	2	2.60.60.20
Domain	PLAT	PKD1 ALOX12B	4.06e-03	21	85	2	PF01477
Domain	PLAT/LH2_dom	PKD1 ALOX12B	4.06e-03	21	85	2	IPR001024
Domain	-	SEMA3F STRN3 LLGL2 DCAF12L1 CORO6 DCAF12L2	4.13e-03	333	85	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA3F STRN3 LLGL2 DCAF12L1 CORO6 DCAF12L2	4.25e-03	335	85	6	IPR015943
Domain	CH	EHBP1L1 CAMSAP3 PLEC	4.50e-03	73	85	3	PS50021
Domain	CH-domain	EHBP1L1 CAMSAP3 PLEC	4.85e-03	75	85	3	IPR001715
Domain	FERM_CS	FRMD7 TLN1	5.29e-03	24	85	2	IPR019747
Domain	HAD-like_dom	EPHX2 PITPNM3 PGP	5.61e-03	79	85	3	IPR023214
Domain	WD40	STRN3 LLGL2 DCAF12L1 CORO6 DCAF12L2	6.58e-03	259	85	5	PF00400
Domain	WD40	STRN3 LLGL2 DCAF12L1 CORO6 DCAF12L2	7.57e-03	268	85	5	SM00320
Domain	WD40_repeat	STRN3 LLGL2 DCAF12L1 CORO6 DCAF12L2	8.04e-03	272	85	5	IPR001680
Domain	WD_REPEATS_1	STRN3 LLGL2 DCAF12L1 CORO6 DCAF12L2	8.79e-03	278	85	5	PS00678
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NAGLU HS3ST4 HS3ST3B1 HS3ST3A1	9.69e-05	54	63	4	MM14633
Pathway	KEGG_GLYCOSAMINOGLYCAN_DEGRADATION	NAGLU HS3ST3B1 HS3ST3A1	1.07e-04	21	63	3	M3624
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NAGLU HS3ST4 HS3ST3B1 HS3ST3A1	1.20e-04	57	63	4	M692
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA3F ZGPAT TNRC18 EHBP1L1 LZTR1 LLGL2 RHBDF2 EP400 ZMIZ2 TLN1 NAGLU PKD1 CPSF1 LRP5 PLEC ESPL1	9.74e-09	1105	85	16	35748872
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR STRN3 SCML2 EP400 MDC1 CAMSAP3 CPSF1 PLEC ESPL1 PRDM2 USP47	2.95e-06	774	85	11	15302935
Pubmed	Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso.	HS3ST3B1 HS3ST3A1	5.90e-06	2	85	2	22475533
Pubmed	Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.	TNRC18 LIN28A	5.90e-06	2	85	2	37774938
Pubmed	Clinical and next-generation sequencing findings in a Chinese family exhibiting severe familial exudative vitreoretinopathy.	ABCA4 LRP5	5.90e-06	2	85	2	29207047
Pubmed	iRhom2 deficiency relieves TNF-α associated hepatic dyslipidemia in long-term PM2.5-exposed mice.	RHBDF2 TNF	5.90e-06	2	85	2	28965953
Pubmed	A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry.	HS3ST3B1 HS3ST3A1	5.90e-06	2	85	2	10520990
Pubmed	Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.	PKD1 FJX1	5.90e-06	2	85	2	31038742
Pubmed	Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.	HS3ST3B1 HS3ST3A1	5.90e-06	2	85	2	15304505
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	5.90e-06	2	85	2	37833372
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	5.90e-06	2	85	2	29563550
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	PRMT6 STRN3 TNRC18 EHBP1L1 SPAST ZMIZ2 UMPS SNRPA LENG9 ALOX12B	7.18e-06	689	85	10	36543142
Pubmed	Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.	HS3ST4 HS3ST3B1 HS3ST3A1	7.71e-06	16	85	3	9988767
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TPR SPNS1 OGT ZMIZ2 CAMSAP3 PLEC PRDM2 TANGO6	8.74e-06	418	85	8	34709266
Pubmed	Altered Hippo signalling in polycystic kidney disease.	PKD1 FJX1	1.77e-05	3	85	2	21381034
Pubmed	iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.	RHBDF2 TNF	1.77e-05	3	85	2	22246778
Pubmed	Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.	RHBDF2 TNF	1.77e-05	3	85	2	22246777
Pubmed	H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation.	TNF LIN28A	1.77e-05	3	85	2	30502053
Pubmed	Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.	KLF9 MDC1	1.77e-05	3	85	2	37962983
Pubmed	Use of duplex PCR-CTPP methods for CYP2E1RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C polymorphisms.	CYP2E1 TNF	1.77e-05	3	85	2	16137184
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	1.77e-05	3	85	2	38875319
Pubmed	Assignment of a locus for autosomal dominant idiopathic scoliosis (IS) to human chromosome 17p11.	HS3ST3B1 HS3ST3A1	1.77e-05	3	85	2	12384783
Pubmed	TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form.	TNF DNASE1	1.77e-05	3	85	2	26065428
Pubmed	Keratinocyte-specific modulation of type VII collagen gene expression by pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta).	COL7A1 TNF	1.77e-05	3	85	2	15810887
Pubmed	USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.	FARSA SLFN13 SLFN11 USP47	3.18e-05	73	85	4	30224337
Pubmed	Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.	HS3ST3B1 HS3ST3A1	3.53e-05	4	85	2	7744762
Pubmed	Genetic risk for ischemic and hemorrhagic stroke.	PKD1 TNF	3.53e-05	4	85	2	16741147
Pubmed	Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase.	CYP2E1 TNF	3.53e-05	4	85	2	19477265
Pubmed	Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.	HS3ST3B1 HS3ST3A1	3.53e-05	4	85	2	9988768
Pubmed	Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation.	PKD1 TNF	3.53e-05	4	85	2	31301888
Pubmed	iRhom2 is required for the secretion of mouse TNFα.	RHBDF2 TNF	3.53e-05	4	85	2	22550345
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TNRC18 SCML2 OGT EP400 MDC1 MEF2A	5.20e-05	268	85	6	33640491
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	DNAAF2 TPP2 TPR ZGPAT SCML2 EP400 MDC1	5.42e-05	396	85	7	26687479
Pubmed	TNFα signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signaling.	PKD1 TNF	5.87e-05	5	85	2	26110849
Pubmed	Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney.	HS3ST3B1 HS3ST3A1	5.87e-05	5	85	2	32017326
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN13 SLFN11	5.87e-05	5	85	2	18355440
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN13 SLFN11	5.87e-05	5	85	2	24089532
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN13 SLFN11	5.87e-05	5	85	2	29528433
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TPP2 TNRC18 OGT SPAST EP400 ZMIZ2 TLN1 SLFN11 SNRPA MEF2A PRDM2	7.76e-05	1103	85	11	34189442
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SFXN1 TLN1 NAGLU CAMSAP3 PKD1 PITPNM3 CPSF1 KCNS2 PRDM2	7.96e-05	736	85	9	29676528
Pubmed	Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.	RHBDF2 TNF	8.80e-05	6	85	2	29776906
Pubmed	Schlafen, a new family of growth regulatory genes that affect thymocyte development.	SLFN13 SLFN11	8.80e-05	6	85	2	9846487
Pubmed	Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l γ.	TLN1 PKD1	8.80e-05	6	85	2	27775029
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SFXN1 TPR SPNS1 AP5S1 LLGL2 OGT HTRA2 KLF9 CPSF1 SLFN11 PGP LIN28A	9.10e-05	1327	85	12	32694731
Pubmed	Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.	SLFN13 SLFN11	1.23e-04	7	85	2	15351786
Pubmed	Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.	SLFN13 SLFN11	1.64e-04	8	85	2	19619625
Pubmed	[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer].	CYP2E1 TNF	1.64e-04	8	85	2	12548461
Pubmed	Confirmation of the novel association at the BTNL2 locus with ulcerative colitis.	BTNL2 TNF	1.64e-04	8	85	2	19659809
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	TPR EP400 TLN1 MDC1 UMPS PLEC	1.68e-04	332	85	6	32786267
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	EPHX2 CYP2E1	2.10e-04	9	85	2	37838304
Pubmed	[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis].	CYP2E1 TNF	2.10e-04	9	85	2	15220553
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	TPR OGT TLN1 CAMSAP3	2.13e-04	119	85	4	35776542
Pubmed	Interaction network of human early embryonic transcription factors.	TNRC18 OGT EP400 ZMIZ2 MDC1 PRDM2	2.27e-04	351	85	6	38297188
Pubmed	Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.	TLN1 PKD1	2.62e-04	10	85	2	11113628
Pubmed	The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers.	EPHX2 CYP2E1	2.62e-04	10	85	2	17498780
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	TPR HTRA2 MDC1 UMPS PLEC	2.80e-04	234	85	5	36243803
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	SFXN1 PRMT6 DNAAF2 TPP2 TLN1 UMPS PGP USP47 TANGO6	2.97e-04	878	85	9	37223481
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TPR ZNF750 SCML2 OGT SGPP2 IRGQ PLEC ESPL1 LCMT2 PRDM2	3.13e-04	1084	85	10	11544199
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	HS3ST4 HS3ST3B1	3.20e-04	11	85	2	15944372
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	SEMA3F LZTR1 LLGL2 LRP5	4.17e-04	142	85	4	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	SEMA3F LZTR1 LLGL2 LRP5	4.29e-04	143	85	4	20198315
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TNRC18 EP400 ZMIZ2 SLFN11 PRDM2 TANGO6	4.42e-04	398	85	6	35016035
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SFXN1 TPR ZGPAT EP400 TLN1 MDC1 CPSF1 PLEC PGP SNRPA ALOX12B	4.52e-04	1353	85	11	29467282
Pubmed	High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.	OGT TNF	4.52e-04	13	85	2	17670746
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	TNRC18 OGT MDC1	5.27e-04	64	85	3	22865885
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TPR SCML2 EP400 MDC1 PLEC	5.46e-04	271	85	5	32433965
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TPR TLN1 CPSF1 UMPS PLEC SNRPA LENG9	5.67e-04	582	85	7	20467437
Pubmed	The mouse as a model for the effects of MHC genes on human disease.	BTNL2 AGPAT1 TNF	6.03e-04	67	85	3	10871872
Pubmed	Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.	EPHX2 CYP2E1	6.07e-04	15	85	2	19575027
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TNRC18 EP400 ZMIZ2 TLN1 MDC1 PLEC	6.62e-04	430	85	6	35044719
Pubmed	Human transcription factor protein interaction networks.	SFXN1 OGT EP400 KLF9 ZMIZ2 MDC1 CPSF1 MEF2A PRDM2 TLX1 TANGO6	7.12e-04	1429	85	11	35140242
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	SFXN1 TPR FARSA TLN1 CPSF1 SNRPA DHTKD1	7.26e-04	607	85	7	39147351
Pubmed	Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.	TPR SCML2 MDC1	7.44e-04	72	85	3	31248990
Pubmed	MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.	TPR OGT	7.84e-04	17	85	2	20479123
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	CYP2E1 TNF ALOX12B PRDM2	8.20e-04	170	85	4	19064572
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PRMT6 TPR FARSA OGT EP400 MDC1 CPSF1 PLEC SNRPA	8.34e-04	1014	85	9	32416067
Pubmed	FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.	HS3ST3B1 HS3ST3A1	8.80e-04	18	85	2	24924191
Pubmed	Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.	BTNL2 TNF	8.80e-04	18	85	2	19143814
Pubmed	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	BTNL2 MDC1 AGPAT1 TNF	9.13e-04	175	85	4	19851445
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	EHBP1L1 ABCA4 PITPNM3 TNF SLFN11 DCAF12L2 USP47	9.70e-04	638	85	7	31182584
Pubmed	Allele Frequencies of 25 Polymorphisms Pertaining to Cancer Risk for Japanese, Koreans and Chinese.	CYP2E1 TNF	9.83e-04	19	85	2	12718576
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	HS3ST4 HS3ST3B1 HS3ST3A1	1.05e-03	81	85	3	39217171
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 TPR TLN1 MDC1 CPSF1 PLEC USP47	1.11e-03	653	85	7	22586326
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	TPP2 TLN1 ESPL1 ECE2 TANGO6	1.18e-03	322	85	5	26514267
Pubmed	TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.	HS3ST4 HS3ST3B1	1.20e-03	21	85	2	27668656
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SFXN1 SPNS1 FARSA EHBP1L1 OGT EP400 CPSF1 PLEC SNRPA	1.31e-03	1082	85	9	38697112
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNRC18 KCNS2 DHTKD1 LCMT2 ADAMTSL2 TANGO6	1.34e-03	493	85	6	15368895
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	TNRC18 EP400	1.44e-03	23	85	2	9225980
Pubmed	Charcot-Marie-Tooth Neuropathy Type 2 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	NAGLU DHTKD1	1.44e-03	23	85	2	20301462
Pubmed	Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.	BTNL2 AGPAT1	1.57e-03	24	85	2	21323541
Pubmed	Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model.	TNF PLEC	1.57e-03	24	85	2	15245428
Pubmed	p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.	ZNF750 COL7A1	1.57e-03	24	85	2	28604778
Pubmed	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	HS3ST3B1 HS3ST3A1	1.57e-03	24	85	2	34653670
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	TPR OGT MDC1 CPSF1	1.58e-03	203	85	4	22083510
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	SFXN1 ZGPAT FARSA OGT TLN1 RP9 PLEC	1.66e-03	701	85	7	30196744
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	SFXN1 TPR FARSA TLN1 CAMSAP3 CPSF1 PLEC SNRPA	1.81e-03	916	85	8	32203420
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	FARSA OGT CPSF1 PLEC	1.85e-03	212	85	4	33462405
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TPP2 STRN3 HTRA2 USP47	1.85e-03	212	85	4	33853758
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	EPHX2 OGT LRP5 PLEC	1.91e-03	214	85	4	22199357
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	TPR EHBP1L1 SPAST TLN1 PLEC	1.93e-03	360	85	5	33111431
Interaction	RCOR1 interactions	TPR ZNF750 LLGL2 OGT QPRT CAMSAP3 PLEC DCAF12L2 ECE2 TLX1 TANGO6	6.36e-06	494	84	11	int:RCOR1
GeneFamily	Schlafen family	SLFN13 SLFN11	1.96e-04	7	56	2	1110
GeneFamily	Sulfotransferases, membrane bound	HS3ST4 HS3ST3B1 HS3ST3A1	2.03e-04	37	56	3	763
GeneFamily	WD repeat domain containing	STRN3 LLGL2 DCAF12L1 CORO6 DCAF12L2	1.29e-03	262	56	5	362
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC18 EP400	2.70e-03	25	56	2	775
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 ZNF750 LZTR1 CYP2E1 DNASE1 ASPDH	8.79e-07	169	85	6	ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 ZNF750 LZTR1 CYP2E1 DNASE1 ASPDH	8.79e-07	169	85	6	922086f218135b734b7d370b871923e50141edce
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EPHX2 SGPP2 CORO6 ALOX12B ADAMTSL2	7.29e-06	140	85	5	7cc891d676555609add6fc7880735d948a2ad801
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZGPAT SGPP2 RP9 SLC38A11 LIN28A	7.29e-06	140	85	5	e64f6aa57bc069cfe970089bd1c298433bfaf771
ToppCell	NS-moderate-d_0-4-Epithelial-Secretory-diff\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZGPAT ASPRV1 ESPL1	9.76e-06	22	85	3	e272dc16cbe6458a34324a6912b5b99d4810a5dd
ToppCell	facs-Kidney-nan-24m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFXN1 EPHX2 CYP2E1 QPRT DNASE1	1.62e-05	165	85	5	906321cb5f299d77436fb5540fd8c52d7532beca
ToppCell	facs-Kidney-nan-24m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFXN1 EPHX2 CYP2E1 QPRT DNASE1	1.62e-05	165	85	5	02a09d0918b103aca21c36b42c5a8a8ebad8686c
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 CYP2E1 QPRT VWA1 ASPDH	1.76e-05	168	85	5	624cf8f439c0a3c877927e085ec260ca79896b5a
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 CYP2E1 VWA1 DNASE1 ASPDH	1.92e-05	171	85	5	48fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCell	droplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 CYP2E1 VWA1 DNASE1 ASPDH	1.92e-05	171	85	5	05fcc72df50a380a913821b5781d9621df37d328
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFXN1 EPHX2 CYP2E1 DNASE1 ASPDH	2.59e-05	182	85	5	faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFXN1 EPHX2 CYP2E1 DNASE1 ASPDH	2.59e-05	182	85	5	be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ABCA4 QPRT HS3ST3B1 HS3ST3A1	3.31e-05	95	85	4	3699ea16660a22ea79fecfea56ece2dfb0f13467
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ABCA4 QPRT HS3ST3B1 HS3ST3A1	3.31e-05	95	85	4	cbfe615d880913bafaf5e7e8d24c3ec14a9351ce
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ABCA4 QPRT HS3ST3B1 HS3ST3A1	3.31e-05	95	85	4	27ac23b87747434a3084cc087e7b884e68f0eab9
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SFXN1 LLGL2 OGT SLFN13 PCSK7	3.78e-05	197	85	5	e4331969bd911d1ebb5453f40a7057297b5389b4
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	PKD1 LRP5	4.56e-05	4	82	2	DOID:898 (is_implicated_in)
Disease	Familial Exudative Vitreoretinopathy	ABCA4 LRP5	7.59e-05	5	82	2	C0339539
Disease	Thyroid Gland Follicular Adenoma	TPR TNF PRDM2	1.27e-04	35	82	3	C0151468
Disease	Thyroid Neoplasm	TPR TNF PRDM2	1.50e-04	37	82	3	C0040136
Disease	polycystic liver disease (implicated_via_orthology)	PKD1 LRP5	1.59e-04	7	82	2	DOID:0050770 (implicated_via_orthology)
Disease	primary sclerosing cholangitis (is_marker_for)	TNF DNASE1	2.11e-04	8	82	2	DOID:0060643 (is_marker_for)
Disease	Thyroid carcinoma	TPR TNF PRDM2	2.52e-04	44	82	3	C0549473
Disease	Anemia, Sickle Cell	UMPS TNF	3.38e-04	10	82	2	C0002895
Disease	Berylliosis	BTNL2 TNF	4.13e-04	11	82	2	C0005138
Disease	Beryllium Disease	BTNL2 TNF	4.13e-04	11	82	2	C2350873
Disease	autoimmune hepatitis (is_marker_for)	TNF DNASE1	4.13e-04	11	82	2	DOID:2048 (is_marker_for)
Disease	liver disease (is_implicated_in)	CYP2E1 TNF	4.94e-04	12	82	2	DOID:409 (is_implicated_in)
Disease	Kawasaki disease (is_implicated_in)	BTNL2 TNF	4.94e-04	12	82	2	DOID:13378 (is_implicated_in)
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD1 LRP5	6.79e-04	14	82	2	DOID:898 (implicated_via_orthology)
Disease	Van Buchem disease	LRP5 ADAMTSL2	1.01e-03	17	82	2	C0432272
Disease	Colorectal Neoplasms	SFXN1 COL7A1 ABCA4 UMPS TNF	1.06e-03	277	82	5	C0009404
Disease	Bronchiectasis	DNAAF2 TNF	1.70e-03	22	82	2	C0006267
Disease	Neoplasm Invasiveness	CYP2E1 TLN1 TNF LIN28A	1.75e-03	184	82	4	C0027626
Disease	Morbilliform Drug Reaction	CYP2E1 TNF	1.86e-03	23	82	2	C0406537
Disease	Drug Eruptions	CYP2E1 TNF	1.86e-03	23	82	2	C0011609
Disease	Postural instability	SFXN1 PRMT6	2.20e-03	25	82	2	HP_0002172
Disease	primary biliary cholangitis (is_marker_for)	TNF DNASE1	2.20e-03	25	82	2	DOID:12236 (is_marker_for)
Disease	middle cerebral artery infarction (biomarker_via_orthology)	CYP2E1 HTRA2 TNF	2.24e-03	93	82	3	DOID:3525 (biomarker_via_orthology)
Disease	coronary artery disease (is_implicated_in)	EPHX2 BTNL2 TNF	2.76e-03	100	82	3	DOID:3393 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHGEAVVPPRSLFDR	EP400	2306	Q96L91
HEPVFIRLNPGDRGV	C4orf33	16	Q8N1A6
PVAGDQFLVPAHEAR	C16orf86	36	Q6ZW13
VRPEQFAHGVPDLAL	ABCA4	186	P78363
SEDFRVIGPAHPILA	BTNL2	26	Q9UIR0
EQVPLHEAPRGAFRL	AP5S1	86	Q9NUS5
PEGQPAPEARVHFRV	CCNQ	16	Q8N1B3
ALERPPVDHGLARLV	DHTKD1	46	Q96HY7
VLRAAFGGAEHVPPE	CAMSAP3	41	Q9P1Y5
VLPAFAGHVPEAVTR	NAGLU	241	P54802
HEEIDRVIGPSRIPA	CYP2E1	326	P05181
RAAVPEHGVAPDAER	KLF9	21	Q13886
FLRVHPDVRAVGAEP	HS3ST3B1	156	Q9Y662
PDVRAVGAEPHFFDR	HS3ST3B1	161	Q9Y662
AGGARPPLLHVAIRE	LZTR1	501	Q8N653
GRPAEVHLERAQPFG	MDC1	311	Q14676
HERLAARSGPVRFEP	LLGL2	561	Q6P1M3
EVRFVHPEPGHVLRT	DNAAF2	66	Q9NVR5
AVHTRRENPAEPGAV	ASPDH	241	A6ND91
FFPVDPGHLREELTR	FRMD7	81	Q6ZUT3
QERVVIADDLPHPFG	LRP5	836	O75197
EVGLPVYAHIRPRDV	DCAF12L2	236	Q5VW00
VHTPRVRVDPDGRCA	CPSF1	136	Q10570
EGLVTDPHSPARFRV	ECE2	766	P0DPD6
PAGHRPALEVEAIRQ	PCSK7	101	Q16549
GPGVLAVPQHRVRFF	LENG9	136	Q96B70
LEPDVRAVVVGFDPH	PGP	161	A6NDG6
PGEDPRFEIVEHFGI	KCNS2	221	Q9ULS6
AEVDLARHAGPVPVQ	EHBP1L1	116	Q8N3D4
ALTRPEPVHEFCAGR	ADAMTSL2	606	Q86TH1
FLRVHPDVRAVGAEP	HS3ST3A1	171	Q9Y663
PDVRAVGAEPHFFDR	HS3ST3A1	176	Q9Y663
LVPVARVAEVRGPAH	QPRT	81	Q15274
EDPRGDFHSPIVLGR	MEF2A	471	Q02078
HVPPLALARVEARGA	FJX1	206	Q86VR8
ILDRHPFLGREVPIS	HTRA2	166	O43464
DRIRQAGPHVPFTVF	ESPL1	1351	Q14674
PRVRLHFVELGSGPA	EPHX2	246	P34913
EVREFAIVPLHAAPG	DNASE1	146	P24855
FNGLEDRVHVLPGPV	PRMT6	126	Q96LA8
PHEGARPLRAVFTAD	CORO6	216	Q6QEF8
DRRPLGHFPDIHFVE	ALOX12B	641	O75342
GHFPDIHFVEEAPRR	ALOX12B	646	O75342
EVGLPVYAHIRPRDV	DCAF12L1	236	Q5VU92
EAPPGRVAFAAVRSH	CBLN3	66	Q6UW01
VADHVFLPQLARPGV	COL7A1	126	Q02388
PDPVLVRGAGHITVF	CHIC1	86	Q5VXU3
VLPEEAVGHARPSRR	SASH3	231	O75995
PGVDPENVFIGRHFI	SLC38A11	86	Q08AI6
ERSIVFGIHPRTADP	SLFN13	861	Q68D06
AIRVHPDVRAVGVEP	HS3ST4	216	Q9Y661
PDVRAVGVEPHFFDR	HS3ST4	221	Q9Y661
HFPGPVTRAEVEARL	IRGQ	546	Q8WZA9
HVLRGLPEEVRLFPS	PRDM2	21	Q13029
IVALGEEPARAVHPL	PKD1	391	P98161
IFSPVAPKEEHVRRG	OGT	901	O15294
RLGVSDPIHGVPEFI	MR1	31	Q95460
DGVRALAFHPVEPVL	STRN3	481	Q13033
IPDVPGNEHAREFLA	RP9	71	Q8TA86
VLGRDAVHAALFPPL	SEMA3F	696	Q13275
HVSPLIGRFVPFAAV	SFXN1	171	Q9H9B4
HEARVFRSIPPEGLA	FARSA	76	Q9Y285
ERSIVFGIHPRTADP	SLFN11	861	Q7Z7L1
APVPGGEAERVRVFH	SPAST	106	Q9UBP0
ADPTERAARVPGVEH	SGPP2	36	Q8IWX5
RSEEGRRQHAFVPEP	ASPRV1	91	Q53RT3
PGFVRVLAHFRPVED	CHP2	81	O43745
EVRHPPVGIAVAVAR	TNRC18	676	O15417
EEAGPERIVISHARP	VWA1	331	Q6PCB0
AARPSAFVPVGEHRL	ZNF750	156	Q32MQ0
DHFGPGPVNVVLRRI	SCML2	381	Q9UQR0
EAIHSPQVAGVPRFR	TPR	2151	P12270
GIRVEVRGAHHFPPS	AGPAT1	81	Q99943
PEVAPDVRLRALHYG	TLN1	2226	Q9Y490
LVVREPPRGAVERHS	SPNS1	236	Q9H2V7
PGQIRRHFIEVPEGA	TPP2	656	P29144
EDSVHDRFIGPLPRE	USP47	146	Q96K76
EPLIHTFLRGVRDPD	TANGO6	956	Q9C0B7
SFGARAELPRIHPVA	UMPS	226	P11172
IVDPRLGFHLPLEVA	PLEC	3946	Q15149
SDPKVRPGAVDVVRH	PITPNM3	756	Q9BZ71
PVRDGVVLEPFRLQH	ZMIZ2	426	Q8NF64
PELAGAVIHARAPAV	nan	91	Q3C1V9
VIRVPAHRPLAGAVA	TLX1	131	P31314
PLHGLERFPDVEAQR	LCMT2	241	O60294
IVDPLARGRAFRHPE	RHBDF2	186	Q6PJF5
FPGFKEVRLVPGRHD	SNRPA	231	P09012
AEGRVEPIHAVVLPR	ZGPAT	356	Q8N5A5
LHFGVIGPQREEFPR	TNF	51	P01375
RAGVALDPPVDVFVH	LIN28A	61	Q9H9Z2