Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

1.62e-048512GO:0106139
GeneOntologyCellularComponentlarge ribosomal subunit

RPL10L MRPL21 RPL39 RPL10

1.96e-04118514GO:0015934
GeneOntologyCellularComponentother organism part

C4A C4B

2.08e-049512GO:0044217
GeneOntologyCellularComponentcytosolic large ribosomal subunit

RPL10L RPL39 RPL10

4.04e-0459513GO:0022625
GeneOntologyCellularComponentribosomal subunit

RPL10L MRPL21 RPL39 RPL10

1.28e-03194514GO:0044391
MousePhenoincreased freezing behavior

FRAS1 WIZ C4A C4B NUFIP1

1.34e-05128345MP:0020421
MousePhenodecreased spleen germinal center size

BTK C4A C4B

1.96e-0522343MP:0008484
MousePhenodecreased spleen germinal center number

BTK C4A C4B

3.29e-0526343MP:0008482
MousePhenoabnormal freezing behavior

FRAS1 WIZ C4A C4B NUFIP1

4.29e-05163345MP:0020420
MousePhenocomplete cleft palate

FRAS1 ZFHX4

5.72e-055342MP:0021213
DomainMob1_phocein

MOB3C MOB3B MOB3A

5.90e-077493PF03637
DomainMOB_kinase_act_fam

MOB3C MOB3B MOB3A

5.90e-077493IPR005301
Domain-

MOB3C MOB3B MOB3A

5.90e-0774931.20.140.30
DomainMob1_phocein

MOB3C MOB3B MOB3A

5.90e-077493SM01388
DomainFerritin-like_SF

MOB3C MOB3B MOB3A

6.05e-0614493IPR009078
DomainTMEM183

TMEM183A TMEM183BP

6.74e-062492IPR026509
DomainRibosomal_L10e

RPL10L RPL10

6.74e-062492IPR001197
DomainRibosomal_L10e_CS

RPL10L RPL10

6.74e-062492IPR018255
DomainRIBOSOMAL_L10E

RPL10L RPL10

6.74e-062492PS01257
Domain-

RPL10L RPL10

2.02e-0534923.90.1170.10
DomainRibosomal_L16

RPL10L RPL10

2.02e-053492PF00252
DomainRibosomal_L10e/L16

RPL10L RPL10

2.02e-053492IPR016180
DomainAnaphylatoxin_comp_syst

C4A C4B

6.71e-055492IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

6.71e-055492IPR001840
DomainANATO

C4A C4B

1.40e-047492SM00104
DomainANAPHYLATOXIN_2

C4A C4B

1.40e-047492PS01178
DomainANAPHYLATOXIN_1

C4A C4B

1.40e-047492PS01177
DomainANATO

C4A C4B

1.40e-047492PF01821
DomainG_CP_dom

GNL1 GNL3

1.40e-047492IPR030378
DomainAnaphylatoxin/fibulin

C4A C4B

1.40e-047492IPR000020
DomainG_CP

GNL1 GNL3

1.40e-047492PS51721
DomainMacrogloblnA2_CS

C4A C4B

1.87e-048492IPR019742
DomainThiol-ester_cl

C4A C4B

1.87e-048492PF10569
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

1.87e-048492IPR019565
DomainA2M_N

C4A C4B

2.99e-0410492PF01835
DomainA2M_N_2

C4A C4B

2.99e-0410492PF07703
DomainA2M_N

C4A C4B

2.99e-0410492IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

2.99e-0410492IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

2.99e-0410492PS00477
DomainA2M_recep

C4A C4B

2.99e-0410492PF07677
DomainA2M_comp

C4A C4B

2.99e-0410492PF07678
DomainA2M

C4A C4B

2.99e-0410492PF00207
DomainA2M_N_2

C4A C4B

2.99e-0410492IPR011625
DomainA2M_comp

C4A C4B

2.99e-0410492IPR011626
DomainMacroglobln_a2

C4A C4B

2.99e-0410492IPR001599
DomainMMR_HSR1

GNL1 GNL3

8.94e-0417492PF01926
DomainC345C

C4A C4B

8.94e-0417492SM00643
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

1.00e-0318492IPR008930
DomainGTP_binding_domain

GNL1 GNL3

1.12e-0319492IPR006073
DomainNTR

C4A C4B

1.12e-0319492PF01759
DomainNetrin_module_non-TIMP

C4A C4B

1.12e-0319492IPR018933
DomainNetrin_domain

C4A C4B

1.65e-0323492IPR001134
DomainNTR

C4A C4B

1.65e-0323492PS50189
DomainTIMP-like_OB-fold

C4A C4B

2.11e-0326492IPR008993
DomainSH3

SORBS2 KALRN BTK FYB2

2.45e-03216494SM00326
DomainSH3_domain

SORBS2 KALRN BTK FYB2

2.62e-03220494IPR001452
DomainPH

KALRN IPCEF1 BTK DGKH

3.03e-03229494PF00169
Domain-

GTF2H1 KALRN IPCEF1 BTK DGKH

3.51e-033914952.30.29.30
DomainPH_dom-like

GTF2H1 KALRN IPCEF1 BTK DGKH

5.04e-03426495IPR011993
DomainPH

KALRN IPCEF1 BTK DGKH

6.02e-03278494SM00233
DomainPH_DOMAIN

KALRN IPCEF1 BTK DGKH

6.09e-03279494PS50003
DomainPH_domain

KALRN IPCEF1 BTK DGKH

6.17e-03280494IPR001849
PathwayREACTOME_MAJOR_PATHWAY_OF_RRNA_PROCESSING_IN_THE_NUCLEOLUS_AND_CYTOSOL

RPL10L RPL39 KRR1 GNL3 RPL10

4.89e-05180325MM15324
PathwayREACTOME_METABOLISM_OF_RNA

RPL10L GTF2H1 RPL39 SUPT5H CPSF1 KRR1 GNL3 RPL10

5.02e-05612328MM15547
PathwayREACTOME_RRNA_PROCESSING

RPL10L RPL39 KRR1 GNL3 RPL10

9.06e-05205325M27685
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

PROK2 KALRN BTK GNB5 DGKH

1.02e-04210325MM15043
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

1.04e-047322MM14685
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

PROK2 KALRN BTK GNB5 DGKH

1.18e-04217325M18437
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

1.39e-048322M27031
PathwayKEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

1.39e-048322M47872
PathwayREACTOME_METABOLISM_OF_RNA

RPL10L GTF2H1 RPL39 SUPT5H CPSF1 KRR1 GNL3 RPL10

1.63e-04724328M16843
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B

2.71e-0411322MM1430
PathwayKEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

2.71e-0411322M47874
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B

3.25e-0412322MM1368
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B

3.83e-0413322M4732
PathwayREACTOME_SIGNALING_BY_GPCR

PROK2 PDE3A KALRN BTK GNB5 DGKH CMKLR1

5.07e-04646327MM14962
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B

5.15e-0415322M7146
PathwayWP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY

C4A C4B

6.65e-0417322MM15944
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B

6.65e-0417322MM1369
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

KALRN BTK GNB5

6.93e-0477323MM15044
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

KALRN BTK GNB5

7.75e-0480323M800
PathwayREACTOME_SIGNALING_BY_GPCR

PROK2 PDE3A KALRN BTK GNB5 DGKH CMKLR1

8.32e-04702327M746
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B

9.25e-0420322M917
PathwayKEGG_RIBOSOME

RPL10L RPL39 RPL10

1.02e-0388323M189
PathwayWP_COMPLEMENT_ACTIVATION

C4A C4B

1.12e-0322322M39502
PathwayPID_CONE_PATHWAY

PDE6H GNB5

1.23e-0323322M117
PathwayREACTOME_EUKARYOTIC_TRANSLATION_ELONGATION

RPL10L RPL39 RPL10

1.24e-0394323M29556
PathwayREACTOME_NONSENSE_MEDIATED_DECAY_NMD_INDEPENDENT_OF_THE_EXON_JUNCTION_COMPLEX_EJC

RPL10L RPL39 RPL10

1.32e-0396323MM15705
PathwayREACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY

RPL10L RPL39 RPL10

1.57e-03102323M29813
PathwayREACTOME_TRANSLATION

RPL10L MRPL21 RPL39 RPL10

1.76e-03231324MM15420
PathwayREACTOME_MRNA_CAPPING

GTF2H1 SUPT5H

1.95e-0329322M745
PathwayREACTOME_MRNA_CAPPING

GTF2H1 SUPT5H

1.95e-0329322MM15409
PathwayREACTOME_ACTIVATION_OF_G_PROTEIN_GATED_POTASSIUM_CHANNELS

KCNJ3 GNB5

2.09e-0330322MM14542
PathwayREACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE

RPL10L RPL39 RPL10

2.10e-03113323M567
PathwayREACTOME_NONSENSE_MEDIATED_DECAY_NMD

RPL10L RPL39 RPL10

2.21e-03115323MM15640
PathwayREACTOME_NONSENSE_MEDIATED_DECAY_NMD

RPL10L RPL39 RPL10

2.26e-03116323M27921
PathwayREACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING

BTK GNB5

2.37e-0332322M14309
PathwayREACTOME_SELENOAMINO_ACID_METABOLISM

RPL10L RPL39 RPL10

2.38e-03118323M27170
PathwayREACTOME_EUKARYOTIC_TRANSLATION_INITIATION

RPL10L RPL39 RPL10

2.49e-03120323M27686
PathwayREACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING

BTK GNB5

2.52e-0333322MM15027
PathwayREACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX

GTF2H1 SUPT5H

2.52e-0333322MM14508
PathwayREACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX

GTF2H1 SUPT5H

2.52e-0333322M26919
PathwayREACTOME_EUKARYOTIC_TRANSLATION_INITIATION

RPL10L RPL39 RPL10

2.67e-03123323MM15415
PathwayREACTOME_INWARDLY_RECTIFYING_K_CHANNELS

KCNJ3 GNB5

2.83e-0335322M1075
PathwayPID_ARF6_PATHWAY

KIF13B IPCEF1

2.83e-0335322M86
PathwayREACTOME_INWARDLY_RECTIFYING_K_CHANNELS

KCNJ3 GNB5

3.00e-0336322MM14544
PathwayWP_OXIDATIVE_DAMAGE_RESPONSE

C4A C4B

4.06e-0342322MM15945
PathwayREACTOME_HIV_TRANSCRIPTION_ELONGATION

GTF2H1 SUPT5H

4.25e-0343322M29569
PathwayREACTOME_GABA_B_RECEPTOR_ACTIVATION

KCNJ3 GNB5

4.25e-0343322M954
PathwayREACTOME_TRANSLATION

RPL10L MRPL21 RPL39 RPL10

4.26e-03295324M8229
PathwayREACTOME_GABA_B_RECEPTOR_ACTIVATION

KCNJ3 GNB5

4.45e-0344322MM15709
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES

GTF2H1 SUPT5H

5.06e-0347322MM15328
PathwayREACTOME_INFLUENZA_INFECTION

RPL10L RPL39 RPL10

5.30e-03157323M4669
PathwayREACTOME_CELLULAR_RESPONSE_TO_STARVATION

RPL10L RPL39 RPL10

5.30e-03157323M41835
Pubmed

Molecular characterization of human homologs of yeast MOB1.

MOB3C MOB3B MOB3A

1.76e-07852319739119
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

2.19e-06252222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

2.19e-06252216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

2.19e-06252215998580
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

2.19e-06252225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

2.19e-06252217728371
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

2.19e-0625227373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

2.19e-06252219062096
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

2.19e-0625223696167
Pubmed

Structure and organization of the C4 genes.

C4A C4B

2.19e-0625226149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

2.19e-0625226149581
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

2.19e-0625221357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

2.19e-06252216098595
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

2.19e-06252219933335
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

2.19e-06252212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

2.19e-0625223542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

2.19e-0625222387317
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

2.19e-0625228132550
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

2.19e-0625222459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

2.19e-06252217645767
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

2.19e-06252215787745
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

2.19e-06252212207352
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

2.19e-0625222395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

2.19e-06252226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

2.19e-0625226192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

2.19e-0625226167582
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

2.19e-06252216908004
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

2.19e-06252230026462
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

2.19e-0625221438267
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

2.19e-0625227365238
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

2.19e-0625226559257
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

2.19e-06252227758680
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

2.19e-06252219150565
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

2.19e-0625227391573
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

2.19e-06252217506029
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

2.19e-06252222387014
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

2.19e-06252217971360
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

2.19e-06252234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

2.19e-06252220506482
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

2.19e-06252223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

2.19e-0625223464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

2.19e-0625222993295
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

2.19e-06252229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

2.19e-06252217971229
Pubmed

Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.

TMEM183A TMEM183BP

2.19e-06252216644869
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

2.19e-06252212480675
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

2.19e-0625226881182
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

2.19e-06252226800705
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

2.19e-06252223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

2.19e-06252223918728
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

2.19e-0625223944109
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

2.19e-06252215390104
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

2.19e-0625223037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

2.19e-06252211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

2.19e-0625224216347
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

2.19e-06252217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

2.19e-06252221880985
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

2.19e-0625221699796
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

2.19e-0625226978711
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

2.19e-0625226950384
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

2.19e-0625222997024
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

2.19e-06252235898513
Pubmed

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.

C4A C4B

2.19e-06252233353966
Pubmed

Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).

C4A C4B

2.19e-0625223008092
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

2.19e-0625228660986
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

2.19e-0625223624865
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

2.19e-06252228873507
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

2.19e-0625228428773
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

2.19e-06252221857912
Pubmed

The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.

C4A C4B

2.19e-0625226609966
Pubmed

Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.

C4A C4B

2.19e-0625222900855
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

2.19e-06252224638111
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

2.19e-0625226208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

2.19e-0625224514997
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

2.19e-062522276882
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

2.19e-06252221345967
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

2.19e-0625225919331
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

2.19e-0625226832377
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

2.19e-0625223167981
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

2.19e-0625223794341
Pubmed

Complement and c4 null alleles in severe chronic adult periodontitis.

C4A C4B

2.19e-06252217257223
Pubmed

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.

C4A C4B

2.19e-0625222272665
Pubmed

Multiple C4/Slp genes distinguished by expression after transfection.

C4A C4B

2.19e-0625223023818
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

2.19e-0625227545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

2.19e-06252230041577
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

2.19e-0625222572548
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

2.19e-06252222785613
Pubmed

The complement component C4 of mammals.

C4A C4B

2.19e-0625222302180
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

2.19e-0625223862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

2.19e-06252234358307
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

2.19e-06252232691186
Pubmed

Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.

C4A C4B

2.19e-06252223259761
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

2.19e-06252218360261
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

2.19e-06252222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

2.19e-06252218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

2.19e-06252229080553
Pubmed

Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).

C4A C4B

2.19e-06252211168010
Pubmed

The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.

C4A C4B

2.19e-0625228390682
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

2.19e-06252226814963
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

2.19e-0625226589636
GeneFamilyMOB kinase activators|STRIPAK complex

MOB3C MOB3B MOB3A

1.44e-077303647
GeneFamilyL ribosomal proteins

RPL10L RPL39 RPL10

8.14e-0551303729
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

9.51e-0593021234
GeneFamilyPhosphodiesterases

PDE3A PDE6H

7.18e-0424302681
GeneFamilyComplement system|Sushi domain containing

C4A C4B

1.62e-0336302492
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B

1.71e-0337302454
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

IPCEF1 BTK DGKH

4.72e-03206303682
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 KCNJ3 IPCEF1 MOB3B FYB2

2.02e-06181515aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellSigmoid-T_cell-Activated_CD4_T|T_cell / Region, Cell class and subclass

RPL39 AHNAK KRR1 GNL3 RPL10

3.28e-062005159c21e6b8d4f8e526950adacf9cc45a5e86d81c1f
ToppCellPosterior_cortex|World / BrainAtlas - Mouse McCarroll V32

KALRN KCNJ3 IPCEF1 RPL10

3.30e-0515951418e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL10L KIF13B IPCEF1 GNB5

3.46e-05161514140b3c7077947c541cff54f6754e2df968345f4d
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL10L IPCEF1 AHNAK GNB5

3.55e-0516251416f9fbcaa0093ffc5a2a5e32db6040e2cb519d47
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SORBS2 ZFHX4 VIT MOB3A

4.79e-05175514085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF13B PDE3A KCNJ3 AHNAK

4.90e-05176514749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE3A SORBS2 PDE6H PCP4L1

5.01e-05177514928118b0ed120ec01c7d753ce523ab609ac24e5f
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A SORBS2 PDE6H PCP4L1

5.01e-05177514dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A SORBS2 PDE6H PCP4L1

5.12e-05178514416f85e51f45ec7949451fd47611a84e33e87245
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A SORBS2 PDE6H PCP4L1

5.23e-051795148da6863edc756540bb097cc7221c1408640d9bb4
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A SORBS2 PDE6H PCP4L1

5.23e-05179514f39c13c99a07d009cc677e363ffe089089c64916
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A SORBS2 KALRN PCP4L1

5.70e-051835148d45dff06a199b1369576657f7f9dc0249c5f841
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL39 IPCEF1 DGKH RPL10

5.70e-05183514aa66149363bb0b6fe1b6044aa2001ace0e4f717e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 KCNJ3 IPCEF1 FYB2

5.70e-05183514d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A SORBS2 KALRN PCP4L1

5.70e-05183514421265fa15d5a028cb567bb0904e670473ef102b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 KCNJ3 IPCEF1 FYB2

6.20e-05187514f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCellIPF-Stromal-SMC|World / Disease state, Lineage and Cell class

PDE3A SORBS2 KALRN C4B

6.33e-05188514b66264e8f8d536ed2beec31e6746c687718f239b
ToppCellMild/Remission-B_intermediate-0|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PWWP2B RPL39 MOB3A RPL10

6.33e-05188514614032d18f8060bb12d1af7a1cf1cf4d8b2b505b
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FRAS1 ZFHX4 DACT2 PCP4L1

6.33e-05188514de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCellIPF-Stromal-SMC|IPF / Disease state, Lineage and Cell class

PDE3A SORBS2 KALRN C4B

6.33e-05188514e98b24c0de41285f01f7ac194ff0a1b59fd5c333
ToppCelldroplet-Fat-SCAT-30m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX4 AHNAK DACT2 PCP4L1

6.46e-051895148161910a19089f8cc5a3f1fda039f41a2488f04f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 IPCEF1 MOB3B DGKH

6.46e-05189514aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 IPCEF1 MOB3B DGKH

6.46e-051895148977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCelldroplet-Fat-SCAT|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX4 AHNAK DACT2 PCP4L1

6.46e-05189514264c59de2adb8bee5bb57633d79d530a8829617b
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FRAS1 PDE3A ZFHX4 KCNJ3

6.73e-05191514156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-Activated_CD4_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPL39 PDE6H IPCEF1 RPL10

6.73e-05191514dabb2d0210e39455db99db155cb36a3b6af43f37
ToppCellControl-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

PDE3A SORBS2 KALRN RPL10

6.73e-051915142da83c493e60ad0278848957645277d76737a188
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 KCNJ3 IPCEF1 FYB2

6.73e-0519151496b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell(4)_B_cells|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RPL39 BTK MOB3B RPL10

6.87e-0519251460f348e38d09312136b077f6a298258475cedd0a
ToppCellMesenchymal_cells-Endosteal_fibro.|Mesenchymal_cells / Lineage and Cell class

AHNAK DACT2 VIT RPL10

7.15e-051945149a4b5de4d1d8a0aa76fed7b36548ea628f3009cc
ToppCellMild/Remission-B_memory-0|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PWWP2B RPL39 MOB3A RPL10

7.15e-051945144866093b50cdf895f06b60684cc3aaa9769aa4dc
ToppCellMild/Remission-B_memory-0|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PWWP2B RPL39 MOB3A RPL10

7.29e-051955143c51f005d8546c570752f5f0ce6b8ac242d3c54b
ToppCellMesenchymal_cells-Endosteal_fibro.|World / Lineage and Cell class

AHNAK DACT2 VIT RPL10

7.29e-05195514d53974d1866e23c894ffd492ea11d20422919b11
ToppCellTransplant_Alveoli_and_parenchyma-Immune-T_and_NK|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

RPL39 IPCEF1 SYTL1 RPL10

7.29e-051955140d3600586b5698dc727687139e8cdf624af541eb
ToppCell(4)_B_follicular|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RPL39 BTK MOB3B RPL10

7.29e-05195514defffb7a58a30d2745d2f93dc4aca7be1b53c4ef
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 ZFHX4 KCNJ3 FYB2

7.44e-05196514c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FRAS1 ZFHX4 C4A C4B

7.58e-0519751488a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FRAS1 ZFHX4 C4A C4B

7.58e-051975142773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCellMild-Lymphoid-T-CCR7+_T|Mild / Condition, Lineage, Cell class and cell subclass

RPL39 IPCEF1 SYTL1 RPL10

7.58e-05197514f23bd8f6ad011730699a5bb7211cd0feeaebc42b
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PDE3A SORBS2 PCP4L1 RPL10

7.58e-05197514470e23dee4ca35e1fd021b7cdd58fcbc90639837
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17|GI_small-bowel / Manually curated celltypes from each tissue

PROK2 RPL39 AHNAK RPL10

7.73e-05198514f4fc0cac858fc6dcd779d7959ccec51f78ea8cc2
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE3A SORBS2 PCP4L1 RPL10

7.73e-05198514f261a37dd07976548b897af86df1d1a0dc069889
ToppCellBiopsy_Other_PF-Mesenchymal-Mesothelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

FRAS1 ZFHX4 C4A C4B

7.73e-0519851486736f01e61bf4961f060b24ee1f1f48340737dd
ToppCelldroplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX4 C4B VIT RPL10

7.73e-05198514d4f74320ea6c1a7e568ee5bc48bb66cb45e1004d
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Smooth_muscle|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

PDE3A SORBS2 DGKH RPL10

7.73e-0519851489986c7756541df364df516329d10775ba0e78a4
ToppCellHealthy_donor|World / disease group, cell group and cell class (v2)

RPL39 AHNAK SYTL1 RPL10

7.73e-051985141ed0b50c9754727a05c27b21f3546bf2e37eef7f
ToppCellMS-IIF-Lymphocyte-T/NK-Treg|IIF / Disease, condition lineage and cell class

RPL39 KALRN IPCEF1 RPL10

7.73e-051985147bbf8403ecf9f8e403b04f18d265ece977cc49e7
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Neuronal-Immature_CPNs|3_mon / Sample Type, Dataset, Time_group, and Cell type.

SORBS2 RPL39 COX7A2 RPL10

7.73e-0519851432d58379a89be19b6b1a494bf033416546771c19
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4|GI_small-bowel / Manually curated celltypes from each tissue

PROK2 RPL39 AHNAK RPL10

7.73e-051985146333e46cd1ccf5841ce15aea98a4b2f5e3ae4675
ToppCellNS-moderate-d_16-33-Epithelial-Basal|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RPL39 COX7A2 PCP4L1 RPL10

7.73e-051985145c52b69d65909b667ef0943e7e04572c9d5b1ba0
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL39 IPCEF1 SYTL1 RPL10

7.73e-051985146c375fc7e53ed7b7b0feba459958d177a65f7272
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RPL39 MOB3C SYTL1 RPL10

7.73e-051985146afb43c7c415c5bb7c577eab56653ede2b349524
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-GC_B_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPL39 BTK SYTL1 RPL10

7.73e-0519851495b8436ceb4fcf24140d684bc4c01eb85746db4c
ToppCellSigmoid-T_cell-Th17|Sigmoid / Region, Cell class and subclass

PROK2 RPL39 IPCEF1 RPL10

7.89e-05199514ff9bbfead7a8c7d1ba910ff1f9c6eb9a9774264c
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17|GI_small-bowel / Manually curated celltypes from each tissue

PROK2 RPL39 AHNAK RPL10

7.89e-05199514508a6efc11b1b45899a968888865731088cac668
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL39 BTK MOB3B RPL10

7.89e-0519951438747e07853f60d11eda9371cf5e6493e21a9cc3
ToppCellSigmoid-(1)_T_cell-(13)_Th17|Sigmoid / shred on region, Cell_type, and subtype

PROK2 RPL39 IPCEF1 RPL10

7.89e-051995141b39191481faf2e8646a1405e30d8579031bd368
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPL39 IPCEF1 SYTL1 RPL10

7.89e-05199514ee29b65a3c545a9d19c2fbcc0364ee235dd018dc
ToppCelldistal-Hematologic-CD8+_Memory/Effector_T-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PROK2 RPL39 IPCEF1 RPL10

7.89e-05199514a2f54e56013ec2c83407fdb3fcbe5d10d146cca4
ToppCellBiopsy_IPF-Mesenchymal-Mesothelial_cells|Biopsy_IPF / Sample group, Lineage and Cell type

FRAS1 ZFHX4 C4A C4B

8.04e-05200514553386523fd8f8f36617a0d81032224b7ddce442
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron|10w / Sample Type, Dataset, Time_group, and Cell type.

RPL39 ZFHX4 KALRN PCP4L1

8.04e-05200514f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCelldistal-1-Hematologic-CD8+_Memory/Effector_T|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PROK2 RPL39 IPCEF1 RPL10

8.04e-05200514daed8b9c19557fba9e7bf1e41e27688ab49ca366
ToppCellNS-control-d_0-4-Epithelial-Basal|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RPL39 PCP4L1 RPL10

1.82e-0496513163268827cac146e57ea89e2d56c82aa1af4915e
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))|Entopeduncular / BrainAtlas - Mouse McCarroll V32

FRAS1 C4A RPL10

2.58e-04108513ba83418023d9d296b0edd4c4e1832a33bc9b3b69
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

FRAS1 C4A RPL10

2.58e-04108513a93a427ab16628c86db3bb17bfecf801f56ce270
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

FRAS1 C4A RPL10

2.58e-04108513673da75b24218557d01ee461a13c426040da74b9
ToppCellcontrol-Epithelial-Basal|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RPL39 PCP4L1 RPL10

2.72e-04110513192e056e4a75317dfa978997081485a9d9744a09
ToppCellcontrol-Epithelial-Basal|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RPL39 PCP4L1 RPL10

3.02e-04114513276e32c2e04c4c060078cd5277ac5a9ae02033f8
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Vipr2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FRAS1 PDE3A VIT

3.42e-041195136425425b2e622c97b6c74c530ccbfe394d3b202d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Serpinf1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PROK2 MOB3B RPL10

3.42e-041195139ffdb432ec06d12eccbc9af9d30c0d24a0a21030
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

PDE3A SORBS2 FYB2

3.68e-041225131cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Aqp5_Vip|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PROK2 MOB3B RPL10

5.06e-041365138f5682422ba0b477c1e0700212948457f106cb10
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sncg|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PROK2 PWWP2B PCP4L1

5.74e-04142513ed91d2ef4c346f7e1a5402846e2a34cee19c24d1
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Low_Quality-13|World / Primary Cells by Cluster

RPL39 COX7A2 RPL10

5.86e-041435139e9823ea5d7a0ab96e8ce1b746efd57946dd29de
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Low_Quality|World / Primary Cells by Cluster

RPL39 COX7A2 RPL10

5.86e-04143513de78a805e6a220ea6cba5a2b59f53f3edb68771d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCNJ3 IPCEF1 FYB2

6.22e-04146513e887e9de895fd453faa703997ef372cc6410fc49
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Serpinf1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PROK2 MOB3B RPL10

6.60e-041495135293c50b3fb41b1edaf9a97354899bd13770078c
ToppCell(00)_Basal|World / shred by cell type and Timepoint

RPL39 AHNAK RPL10

6.60e-0414951349e39206f37cee124ca4763c79425b805e50624b
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-7|TCGA-Bladder / Sample_Type by Project: Shred V9

BTK CMKLR1 MOB3A

6.73e-041505133ab17045b2c43bb4f0ebba6aa0cfb22e076a24f9
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tfh|blood / Manually curated celltypes from each tissue

RPL39 IPCEF1 RPL10

7.26e-041545135ff380205fa7ab97ba21f6512bc9e14c0fb320b6
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PROK2 KALRN CMKLR1

7.26e-04154513ea5d0da5dd8ccfc19969aec35f044db77d589f54
ToppCellNS-critical-d_0-4-Lymphoid-NKT|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RPL39 PDE6H RPL10

7.26e-0415451308ffa4b6f4a1c3de037acf9d30bd14c195738ad9
ToppCellcritical-Epithelial-Basal|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RPL39 PCP4L1 RPL10

7.40e-04155513cb6fbd36aa1fab29a1667ee13441bddc3d28846f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX4 DACT2 RPL10

7.54e-041565132cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

RPL39 AHNAK RPL10

7.54e-04156513e308328f560c5ee7e9f95ac5db162f2d821ca39c
ToppCellInt-URO-Lymphocyte-T_NK-CD8_TCM|Int-URO / Disease, Lineage and Cell Type

IQCH GNB5 RPL10

7.82e-04158513edcc5a26d4571b179f3ae538fed23b661e4677dd
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RPL10L SCN11A KCNJ3

7.96e-04159513e47d9fefa9e9fcc7812336874a456077ec44b722
ToppCellLV-05._Cytoplasmic_Cardiomyocyte_I|World / Chamber and Cluster_Paper

RPL39 COX7A2 RPL10

8.11e-0416051330df347c4f4f119db4198727acb468d0ee61f37b
ToppCellNS-critical-d_07-13-Epithelial-Basal|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RPL39 PCP4L1 RPL10

8.11e-04160513f538ce75500773b5dda53fec4cde2f557d816f4e
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

PROK2 AHNAK VIT

8.11e-0416051358ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCellICU-NoSEP-Lymphocyte-T_NK-CD8_TCM|ICU-NoSEP / Disease, Lineage and Cell Type

RPL10L RPL39 RPL10

8.11e-04160513a1bf6ed365cbc1ddb57c132a42dbe6485d45f544
ToppCellfacs-Trachea-18m-Hematologic-myeloid-granulocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCN11A BTK FYB2

8.26e-04161513d1f2e5245c7c247b684f48f9f877e149a3ee7c06
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX4 DACT2 RPL10

8.26e-04161513e3327c296d48e821004e61a573abb75624a6f040
ToppCellRV-13._Vascular_Smooth_Muscle|RV / Chamber and Cluster_Paper

KALRN DGKH RPL10

8.26e-0416151347b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF13B AHNAK DGKH

8.41e-04162513bc63a96ad3ba0b3433e3679d7a005f47709ff384
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PDE6H AHNAK BTK

8.41e-0416251330508c4007faa38b76246e3c6d7b3fde4492cc85
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PDE6H AHNAK BTK

8.41e-0416251333b73c6727b5c5ada2dddf304f56d84397725ca8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PDE6H AHNAK BTK

8.41e-0416251344ef0932ee38964ff11edc2aa14698d9db3b2b6b
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

SORBS2 KALRN RPL10

8.56e-04163513977a970b1296234c22178420294cea73506ee02f
DiseaseT-cell acute lymphoblastic leukemia (implicated_via_orthology)

RPL10L RPL10

7.77e-063482DOID:5603 (implicated_via_orthology)
Diseaseautistic disorder (implicated_via_orthology)

RPL10L RPL10

1.55e-054482DOID:12849 (implicated_via_orthology)
Diseasespondyloepiphyseal dysplasia congenita (implicated_via_orthology)

RPL10L RPL10

3.87e-056482DOID:14789 (implicated_via_orthology)
Diseasesyndromic X-linked intellectual disability Najm type (implicated_via_orthology)

RPL10L RPL10

5.41e-057482DOID:0060807 (implicated_via_orthology)
DiseaseComplement deficiency disease

C4A C4B

1.32e-0333482C0272242
DiseaseGraves' disease (is_implicated_in)

C4A C4B

1.85e-0339482DOID:12361 (is_implicated_in)
Diseaseautistic disorder (is_implicated_in)

C4B RPL10

2.14e-0342482DOID:12849 (is_implicated_in)
Diseasesystemic lupus erythematosus (implicated_via_orthology)

C4A C4B

2.24e-0343482DOID:9074 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SCN11A KALRN COX7A2

2.39e-03163483DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KEKTTRKKRNVNFQK

C4B

671

P0C0L5
QKKKTSPLNFKKRLF

BTK

16

Q06187
KSKKSRFKLPKFNFS

AHNAK

3346

Q09666
RRHFKNKVPEKQKLF

COX7A2

21

P14406
KCFKQRALRPVFKKS

GNB5

16

O14775
AEVKFFPKKQRSKGK

IQCH

226

Q86VS3
KQVFNKDKTFRPKRK

MOB3B

6

Q86TA1
FINRKCQKQRKKKPA

FRAS1

3921

Q86XX4
LKQVFNKDKTFRPKR

MOB3A

6

Q96BX8
DKAKKFRLNREGKQK

CCDC47

391

Q96A33
RFKKVPHNINFREKK

CPSF1

891

Q10570
ENNESPKKKTFKRRK

PDE3A

1056

Q14432
NIKKQKKVRDGRKSF

KALRN

1786

O60229
RFLPQFKHKNVNKRK

KRR1

241

Q13601
PFSVKQKKKQLQDKR

GNL1

6

P36915
KEFQRNIKKKRACFP

PMS2P1

371

A4D2B8
PNRKSFTKKKSNKFA

MTPAP

536

Q9NVV4
VFRIVPKFKKEKVQK

DGKH

1126

Q86XP1
KRKRSKRKKEVPFFG

PROK2

86

Q9HC23
AIQGKFRRFQKRKKD

PCP4L1

51

A6NKN8
KKELRKSFVKRCKNP

IPCEF1

336

Q8WWN9
KASKALKKKIRRFQP

DACT2

751

Q5SW24
ITKRVKAKKNAAPFR

GNL3

216

Q9BVP2
PFSEFFKLRFNRKKK

PWWP2B

546

Q6NUJ5
KEKTTRKKRNVNFQK

C4A

671

P0C0L4
KQVFAKDKTFRPRKR

MOB3C

6

Q70IA8
NNHFFRLNLPKKKKK

KIF13B

536

Q9NQT8
KFKFPGRQKIHISKK

RPL10L

156

Q96L21
KRKTAVKKRNLNPVF

SYTL1

316

Q8IYJ3
NKKRKKNVFNPKRVV

SMARCAD1

341

Q9H4L7
TFRIKRFLAKKQKQN

RPL39

6

P62891
KFKFPGRQKIHISKK

RPL10

156

P27635
FNFKFKKQSPRLKSK

TMEM183BP

256

Q1AE95
KEFQRNIKKKRACFP

PMS2P2

236

O95744
QQFFKKEKDRFKIKK

FYB2

546

Q5VWT5
ERRFSFQKKKKKVAN

WIZ

746

O95785
FAKRKKFKRPPQRLF

SUPT5H

326

O00267
ELRELKKFFKTRKPK

SLC25A43

321

Q8WUT9
QRKKEKPKKFTRQPK

SANBR

581

Q6NSI8
FRRKKNSAPKKQTEK

SORBS2

706

O94875
DKNKPFSRVQKVKFK

CCDC15

291

Q0P6D6
KLQRNRLAKTKKPFK

CMKLR1

246

Q99788
FKQRQTRQFKSKPPK

PDE6H

26

Q13956
PKFKRKANKELEEKN

GTF2H1

101

P32780
RAKEKKFKINIGKPF

ZFHX4

2936

Q86UP3
FNFKFKKQSPRLKSK

TMEM183A

256

Q8IXX5
KQKKKKRKEPVFHFF

NUFIP1

161

Q9UHK0
ENRKKSFEKTNPKRK

NUFIP1

421

Q9UHK0
ALEQLFKKSKPNKRK

VIT

581

Q6UXI7
KRKNFKKKRIVTTPQ

MRPL21

176

Q7Z2W9
KKRKLFGNKKRKSFF

SCN11A

456

Q9UI33
KSKAKPSYKQKRQRN

ZNF280C

586

Q8ND82
QLVPKKKRQRFVDKN

KCNJ3

36

P48549