Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP25 MALT1 CAPN5 USP28 CTSZ	7.77e-05	192	46	5	GO:0008234
GeneOntologyMolecularFunction	AMP-activated protein kinase activity	PRKAB1 PRKAB2	2.31e-04	10	46	2	GO:0004679
GeneOntologyCellularComponent	nucleotide-activated protein kinase complex	PRKAB1 PRKAB2	2.57e-04	11	46	2	GO:0031588
Domain	AMPK1_CBM	PRKAB1 PRKAB2	6.20e-06	2	47	2	IPR032640
Domain	AMPKBI	PRKAB1 PRKAB2	6.20e-06	2	47	2	PF04739
Domain	AMPKBI	PRKAB1 PRKAB2	6.20e-06	2	47	2	SM01010
Domain	ASC_dom	PRKAB1 PRKAB2	6.20e-06	2	47	2	IPR006828
Domain	AMPK1_CBM	PRKAB1 PRKAB2	6.20e-06	2	47	2	PF16561
Domain	UIM	USP25 USP28	1.26e-03	21	47	2	SM00726
Domain	SRCR	SSC4D CD163L1	1.26e-03	21	47	2	PF00530
Domain	UIM	USP25 USP28	1.65e-03	24	47	2	PS50330
Domain	SR	SSC4D CD163L1	1.79e-03	25	47	2	SM00202
Domain	-	SSC4D CD163L1	1.79e-03	25	47	2	3.10.250.10
Domain	UIM_dom	USP25 USP28	1.79e-03	25	47	2	IPR003903
Domain	SRCR_1	SSC4D CD163L1	1.94e-03	26	47	2	PS00420
Domain	SRCR_2	SSC4D CD163L1	1.94e-03	26	47	2	PS50287
Domain	SRCR-like_dom	SSC4D CD163L1	1.94e-03	26	47	2	IPR017448
Domain	THIOL_PROTEASE_CYS	CAPN5 CTSZ	1.94e-03	26	47	2	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN5 CTSZ	2.09e-03	27	47	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN5 CTSZ	2.09e-03	27	47	2	PS00639
Domain	SRCR	SSC4D CD163L1	2.09e-03	27	47	2	IPR001190
Domain	Pept_cys_AS	CAPN5 CTSZ	2.25e-03	28	47	2	IPR000169
Pathway	REACTOME_LIPOPHAGY	PRKAB1 PRKAB2	2.39e-04	9	37	2	M27936
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	DSE VCAN	2.98e-04	10	37	2	MM14801
Pathway	REACTOME_ACTIVATION_OF_PPARGC1A_PGC_1ALPHA_BY_PHOSPHORYLATION	PRKAB1 PRKAB2	2.98e-04	10	37	2	M27146
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	DSE VCAN	3.63e-04	11	37	2	M27105
Pathway	BIOCARTA_LEPTIN_PATHWAY	PRKAB1 PRKAB2	3.63e-04	11	37	2	M18053
Pubmed	AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification.	PRKAB1 PRKAB2	1.79e-06	2	47	2	33454005
Pubmed	AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival.	PRKAB1 PRKAB2	1.79e-06	2	47	2	32877674
Pubmed	Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.	PRKAB1 PRKAB2	1.79e-06	2	47	2	36543129
Pubmed	Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function.	PRKAB1 PRKAB2	1.79e-06	2	47	2	19723702
Pubmed	USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines.	USP25 USP28	1.79e-06	2	47	2	32578360
Pubmed	AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.	PRKAB1 PRKAB2	1.79e-06	2	47	2	26039451
Pubmed	AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.	PRKAB1 PRKAB2	1.79e-06	2	47	2	26023060
Pubmed	Muscle-specific AMPK β1β2-null mice display a myopathy due to loss of capillary density in nonpostural muscles.	PRKAB1 PRKAB2	1.79e-06	2	47	2	24522207
Pubmed	Dual regulation of Fbw7 function and oncogenic transformation by Usp28.	USP28 FBXW7	1.79e-06	2	47	2	25437563
Pubmed	Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle.	PRKAB1 PRKAB2	1.79e-06	2	47	2	10544261
Pubmed	The role of AMP-activated protein kinase in the expression of the dystrophin-associated protein complex in skeletal muscle.	PRKAB1 PRKAB2	1.79e-06	2	47	2	29401588
Pubmed	Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations.	ZIC2 ZIC3	1.79e-06	2	47	2	12522805
Pubmed	Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25.	USP25 USP28	1.79e-06	2	47	2	11597335
Pubmed	AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.	PRKAB1 PRKAB2	1.79e-06	2	47	2	21896769
Pubmed	Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.	PRKAB1 PRKAB2	1.79e-06	2	47	2	9575201
Pubmed	ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.	ZIC2 ZIC3	1.79e-06	2	47	2	39358345
Pubmed	Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.	USP25 USP28	5.36e-06	3	47	2	30926242
Pubmed	Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.	USP25 USP28	5.36e-06	3	47	2	30926243
Pubmed	Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily.	USP25 USP28	5.36e-06	3	47	2	29131570
Pubmed	AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells.	MUC5B PRKAB1	5.36e-06	3	47	2	21619869
Pubmed	Ubiquitin-specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma.	USP28 FBXW7	5.36e-06	3	47	2	35880246
Pubmed	Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons.	PRKAB1 PRKAB2	5.36e-06	3	47	2	27467571
Pubmed	The ubiquitin-specific protease USP28 is required for MYC stability.	USP28 FBXW7	5.36e-06	3	47	2	17558397
Pubmed	Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.	USP28 FBXW7	5.36e-06	3	47	2	17873522
Pubmed	Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.	PRKAB1 PRKAB2	5.36e-06	3	47	2	27411013
Pubmed	The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.	ZIC2 ZIC3	5.36e-06	3	47	2	22024047
Pubmed	Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.	PRKAB1 PRKAB2	5.36e-06	3	47	2	16505254
Pubmed	Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans.	ZIC2 ZIC3	5.36e-06	3	47	2	14679585
Pubmed	Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation.	ZIC2 ZIC3	5.36e-06	3	47	2	15261827
Pubmed	The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired.	ZIC2 ZIC3	5.36e-06	3	47	2	8557628
Pubmed	Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise.	PRKAB1 PRKAB2	1.07e-05	4	47	2	28389470
Pubmed	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.	PRKAB1 PRKAB2	1.07e-05	4	47	2	24185692
Pubmed	Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.	PRKAB1 PRKAB2	1.07e-05	4	47	2	27941154
Pubmed	Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.	ZIC2 ZIC3	1.07e-05	4	47	2	15895369
Pubmed	SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.	ZIC2 ZIC3	1.07e-05	4	47	2	34638777
Pubmed	An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.	ZIC2 ZIC3	1.07e-05	4	47	2	30297839
Pubmed	GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.	USP28 FBXW7	1.07e-05	4	47	2	22144179
Pubmed	Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase.	PRKAB1 PRKAB2	1.07e-05	4	47	2	8621499
Pubmed	A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits.	PRKAB1 PRKAB2	1.07e-05	4	47	2	17012231
Pubmed	AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.	PRKAB1 PRKAB2	1.07e-05	4	47	2	15058305
Pubmed	AMP kinase promotes glioblastoma bioenergetics and tumour growth.	PRKAB1 PRKAB2	1.07e-05	4	47	2	29915361
Pubmed	Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.	ZIC2 ZIC3	1.07e-05	4	47	2	11053430
Pubmed	The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.	PRKAB1 PRKAB2	1.07e-05	4	47	2	20534808
Pubmed	A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.	ZIC2 ZIC3	1.07e-05	4	47	2	7931345
Pubmed	Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.	USP28 FBXW7	1.07e-05	4	47	2	25716680
Pubmed	Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.	PRKAB1 PRKAB2	1.78e-05	5	47	2	22363791
Pubmed	Myogenic repressor I-mfa interferes with the function of Zic family proteins.	ZIC2 ZIC3	1.78e-05	5	47	2	15207726
Pubmed	Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro.	PRKAB1 PRKAB2	1.78e-05	5	47	2	8626596
Pubmed	USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.	USP28 FBXW7	1.78e-05	5	47	2	34636321
Pubmed	Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease.	PRKAB1 PRKAB2	1.78e-05	5	47	2	26961958
Pubmed	Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.	PRKAB1 PRKAB2	1.78e-05	5	47	2	24808538
Pubmed	Mammalian AMP-activated protein kinase subfamily.	PRKAB1 PRKAB2	1.78e-05	5	47	2	8557660
Pubmed	USP37 Deubiquitinates CDC73 in HPT-JT Syndrome.	USP25 USP28	2.67e-05	6	47	2	35742816
Pubmed	AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle.	PRKAB1 PRKAB2	2.67e-05	6	47	2	26034200
Pubmed	AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.	PRKAB1 PRKAB2	2.67e-05	6	47	2	9224708
Pubmed	Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications.	PRKAB1 PRKAB2	2.67e-05	6	47	2	22897928
Pubmed	Physical and functional interactions between Zic and Gli proteins.	ZIC2 ZIC3	2.67e-05	6	47	2	11238441
Pubmed	Zic2 patterns binocular vision by specifying the uncrossed retinal projection.	ZIC2 ZIC3	3.74e-05	7	47	2	13678579
Pubmed	Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules.	PRKAB1 PRKAB2	3.74e-05	7	47	2	17767908
Pubmed	Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.	PRKAB1 PRKAB2	3.74e-05	7	47	2	10698692
Pubmed	Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.	PRKAB1 PRKAB2	3.74e-05	7	47	2	25195104
Pubmed	Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.	ZIC2 ZIC3	3.74e-05	7	47	2	35817961
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MALT1 GANAB SLC25A12 HERC1 EIF2AK2 CLN5 IPO11 PRKAB1 PRKAB2	4.76e-05	1284	47	9	17353931
Pubmed	The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.	ZIC2 ZIC3	4.98e-05	8	47	2	9070329
Pubmed	Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system.	PRKAB1 PRKAB2	4.98e-05	8	47	2	10098881
Pubmed	TSC2 mediates cellular energy response to control cell growth and survival.	PRKAB1 PRKAB2	6.40e-05	9	47	2	14651849
Pubmed	Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.	PPT2 CLN5	6.40e-05	9	47	2	15647513
Pubmed	Spatiotemporal expression of Zic genes during vertebrate inner ear development.	ZIC2 ZIC3	7.99e-05	10	47	2	23606270
Pubmed	Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.	ZIC2 ZIC3	7.99e-05	10	47	2	15136147
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	ZIC2 ZIC3	7.99e-05	10	47	2	18298960
Pubmed	Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.	SFMBT2 CTSZ	7.99e-05	10	47	2	17302988
Pubmed	A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.	ZIC2 ZIC3	7.99e-05	10	47	2	21211521
Pubmed	SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.	PRKAB1 PRKAB2	7.99e-05	10	47	2	19720090
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	MUC5B CAPN5 GANAB PPT2 PZP ITIH1 CTSZ CLN5	8.47e-05	1070	47	8	23533145
Pubmed	Autophagy is required for lung development and morphogenesis.	PRKAB1 PRKAB2	9.75e-05	11	47	2	31162135
Pubmed	Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.	ZIC2 ZIC3	9.75e-05	11	47	2	22623663
Pubmed	Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.	OAS3 EIF2AK2	9.75e-05	11	47	2	12447867
Pubmed	METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.	USP28 FBXW7	9.75e-05	11	47	2	36602428
Pubmed	USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.	USP25 USP28	1.17e-04	12	47	2	37339955
Pubmed	RBM24 is a major regulator of muscle-specific alternative splicing.	USP25 USP28	1.17e-04	12	47	2	25313962
Pubmed	Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.	OAS3 MALT1	1.17e-04	12	47	2	35850054
Pubmed	HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	PRKAB1 PRKAB2	1.17e-04	12	47	2	21344388
Pubmed	Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.	PRKAB1 PRKAB2	1.38e-04	13	47	2	18836454
Pubmed	Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection.	PRKAB1 PRKAB2	1.38e-04	13	47	2	20392842
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP25 PRSS48 USP28	1.83e-04	81	47	3	12838346
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	GANAB SLC25A12 MYO9B FBXW7	1.91e-04	211	47	4	17314511
Pubmed	New semidominant mutations that affect mouse development.	ZIC2 ZIC3	2.12e-04	16	47	2	15384171
Pubmed	Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.	ZIC2 ZIC3	2.70e-04	18	47	2	17490632
Pubmed	AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.	PRKAB1 PRKAB2	2.70e-04	18	47	2	16054041
Pubmed	Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.	OAS3 SHANK2	3.01e-04	19	47	2	23149075
Pubmed	Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.	OAS3 EIF2AK2	3.01e-04	19	47	2	1708818
Pubmed	AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.	PRKAB1 PRKAB2	3.69e-04	21	47	2	19217427
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	ZIC2 ZIC3	4.06e-04	22	47	2	18448648
Pubmed	A genomic analysis of rat proteases and protease inhibitors.	PZP PRSS48	4.44e-04	23	47	2	15060002
Pubmed	Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.	ZIC2 ZIC3	5.26e-04	25	47	2	17507568
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	CHKB PRKAB1 PRKAB2	5.40e-04	117	47	3	18996102
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	ZIC2 ZIC3	5.69e-04	26	47	2	22992956
Pubmed	Role of phosphorylation in the nuclear biology of HIV-1.	PRKAB1 PRKAB2	6.14e-04	27	47	2	21651489
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	USP25 PELI1 OIT3 SH3RF1	7.41e-04	302	47	4	30561431
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	PRKAB1 PRKAB2	7.59e-04	30	47	2	16306228
Interaction	PARS2 interactions	DSE PRKAB1 PRKAB2 FBXW7	1.49e-05	64	47	4	int:PARS2
Interaction	PRKAG2 interactions	ALOXE3 GANAB PRKAB1 PRKAB2	1.90e-05	68	47	4	int:PRKAG2
Cytoband	4q31.3	PRSS48 FBXW7	4.68e-04	31	47	2	4q31.3
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SSC4D CD163L1	1.24e-03	27	35	2	1253
GeneFamily	Ubiquitin specific peptidases	USP25 USP28	5.25e-03	56	35	2	366
GeneFamily	Sterile alpha motif domain containing	SHANK2 SFMBT2	1.26e-02	88	35	2	760
GeneFamily	WD repeat domain containing	HERC1 CFAP44 FBXW7	1.40e-02	262	35	3	362
Coexpression	GSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN	USP25 OAS3 MALT1 FHL3 EIF2AK2	2.77e-05	198	47	5	M8969
Coexpression	GSE22886_NAIVE_CD4_TCELL_VS_12H_ACT_TH1_UP	USP25 MALT1 HERC1 CHKB CARS2	2.84e-05	199	47	5	M4521
Coexpression	GSE37533_PPARG1_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN	USP25 OAS3 MALT1 FHL3 EIF2AK2	2.91e-05	200	47	5	M8967
Coexpression	ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_UP	USP25 PELI1 OAS3 SH3RF1 CARS2 EIF2AK2 CTSZ DSE SEC14L1	6.68e-05	1012	47	9	M40868
Coexpression	GSE32901_TH1_VS_TH17_NEG_CD4_TCELL_DN	MUC5B CFAP44 CD163L1 CLN5	7.27e-05	124	47	4	M8923
ToppCell	Control\|World / Disease state, Lineage and Cell class	MALT1 MYO9B CD163L1 DSE VCAN	1.65e-06	189	47	5	fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCell	COVID_non-vent\|World / Disease condition, Lineage, Cell class and subclass	PELI1 OAS3 EIF2AK2 CTSZ VCAN	2.18e-06	200	47	5	accef1050963dc91e189ac3d38228f15bf57e06e
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BTNL8 SFMBT2 DSE VCAN	1.57e-05	143	47	4	7adc34d8ad11e57950a5a258ae9bf8f52259385a
ToppCell	VE-CD8-antiviral_CD4\|VE / Condition, Cell_class and T cell subcluster	USP25 OAS3 PZP EIF2AK2	1.80e-05	148	47	4	f49f579650b57cc4c6c7a7fa726447740d3dc695
ToppCell	PBMC-Control-cDC_1\|Control / Compartment, Disease Groups and Clusters	OAS3 EIF2AK2 USP28 CD163L1	2.21e-05	156	47	4	9b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	MYO9B CD163L1 SFMBT2 SEC14L1	2.95e-05	168	47	4	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MALT1 MYO9B DSE VCAN	4.03e-05	182	47	4	c3eafdc11858566aa7692b2f5dbe72ac01fb769a
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MALT1 CTSZ DSE VCAN	4.21e-05	184	47	4	e343dd7777a29048e3f12a939f7f782b8b7b4fea
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PELI1 MALT1 MYO9B CD163L1	4.58e-05	188	47	4	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	NS-critical-d_07-13-Myeloid-Monocyte-derived_Macrophage\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	OAS3 EIF2AK2 CTSZ VCAN	5.07e-05	193	47	4	0dd83b21e164147abfd511a927615c40a28781a2
ToppCell	Control-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	MYO9B CD163L1 DSE VCAN	5.17e-05	194	47	4	c35bf04d5e7450cb6679a036fcabb1b28f409f29
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	OAS3 EIF2AK2 CTSZ VCAN	5.17e-05	194	47	4	e36d1fd141bdcbd9ed66a33de6cdfde77189a0c1
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	MALT1 MYO9B CD163L1 CTSZ	5.17e-05	194	47	4	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	metastatic_Lymph_Node\|World / Location, Cell class and cell subclass	OAS3 MUC5B EIF2AK2 VCAN	5.17e-05	194	47	4	af6b5806238a610443564754367e91ce378c4a6d
ToppCell	NS-moderate-d_16-33-Myeloid-Monocyte-derived_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	OAS3 EIF2AK2 DSE VCAN	5.27e-05	195	47	4	d87c83d2d421c9291d0a10bc9db850e9fb337667
ToppCell	Control-Myeloid\|Control / Disease state, Lineage and Cell class	MYO9B CD163L1 CTSZ VCAN	5.27e-05	195	47	4	46ce2e403ca5d757e5ba17349b6c7ce5cde1f195
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	OAS3 EIF2AK2 DSE VCAN	5.27e-05	195	47	4	9c9634906168239cf978adb398787692437bf9e7
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	PELI1 MALT1 MYO9B SEC14L1	5.27e-05	195	47	4	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	PELI1 MALT1 MYO9B SEC14L1	5.27e-05	195	47	4	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PELI1 MALT1 DSE VCAN	5.38e-05	196	47	4	c2bbb48c4aa979b03cb6f4ce9f351f492977c992
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PELI1 MALT1 DSE VCAN	5.38e-05	196	47	4	64c2abc0087bf2ae547932377f3662e3be1cc63e
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	OIT3 HERC1 SFMBT2 SEC14L1	5.38e-05	196	47	4	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9B CD163L1 SFMBT2 VCAN	5.49e-05	197	47	4	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	3'-Broncho-tracheal-Immune_Myeloid\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MALT1 CTSZ DSE VCAN	5.49e-05	197	47	4	d568354aff89ac84dd06360f19100ef578a041ed
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MALT1 SFMBT2 CTSZ DSE	5.49e-05	197	47	4	515a2d0ee2bd3fc0a5a0c315e2b0c752e6af7406
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MALT1 SFMBT2 CTSZ DSE	5.49e-05	197	47	4	4fccdc69ab4b966de6465f06677435e6f6e6abcd
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MALT1 SFMBT2 CTSZ DSE	5.49e-05	197	47	4	bfa04e5f4156a01df4217b1f59676edb0a7563e1
ToppCell	COVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi\|lung / Disease (COVID-19 only), tissue and cell type	MYO9B SFMBT2 CTSZ VCAN	5.49e-05	197	47	4	3896729740d151f0eb845f1961c7b969bfbdd28d
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	OAS3 MYO9B EIF2AK2 DSE	5.60e-05	198	47	4	61ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MALT1 CTSZ DSE VCAN	5.60e-05	198	47	4	3a1707318814dabdec48f91fa6bd223f5b879653
ToppCell	wk_20-22-Hematologic-Myeloid-SPP1+_Mac\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MYO9B CD163L1 SFMBT2 CTSZ	5.71e-05	199	47	4	7c19f1b1f4369edd035ca9cdcf4e653771fc4648
ToppCell	control-CD163+_Monocytes_(Sample_ID1_d7)\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	OAS3 EIF2AK2 CTSZ VCAN	5.71e-05	199	47	4	933201d32eda12a89660bdbae9114a95cc428a38
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP25 HERC1 SHANK2 FBXW7	5.71e-05	199	47	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B SHANK2 SH3RF1 TMEM63A	5.82e-05	200	47	4	c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B SHANK2 SH3RF1 TMEM63A	5.82e-05	200	47	4	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B SHANK2 SH3RF1 TMEM63A	5.82e-05	200	47	4	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	Control-CD4+_T_activated\|Control / Disease condition and Cell class	OAS3 SHANK2 RTP2	2.49e-04	116	47	3	e3d1a90a229f5697b2b715574bb96790a435f73b
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	OAS3 SHANK2 RTP2	2.62e-04	118	47	3	f76fc6db7368a1e8e5e4f8535fc3dc78afe13b9b
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OAS3 SHANK2 RTP2	2.62e-04	118	47	3	0dcac16eea8e7978de370a815da9a0cdd212598e
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OAS3 SHANK2 RTP2	2.62e-04	118	47	3	7da3957d102e9f9825fc2609d6d0bd9ca6a3fba4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OAS3 SHANK2 RTP2	2.62e-04	118	47	3	c5c6724e0e526d7c2fc8cabff4a112a900ec997f
ToppCell	Control-Lymphoid_T/NK-CD4+_T_activated\|Control / Disease group, lineage and cell class	OAS3 SHANK2 RTP2	2.69e-04	119	47	3	d7352d0dafbb664619b7a1e3cd07b159fdfec197
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 HDAC10 MYO9B	2.96e-04	123	47	3	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-9\|TCGA-Kidney / Sample_Type by Project: Shred V9	SLC25A12 HERC1 ZIC3	3.64e-04	132	47	3	f1ef63a4842ab6ca584a9dcc2dd5b2108fc990aa
ToppCell	droplet-Lung-1m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l14\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SSC4D SH3RF1 SEC14L1	3.64e-04	132	47	3	14a512f433315892bf0326419f23d0d5919d01ec
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	PELI1 CAPN5 FHL3	4.89e-04	146	47	3	a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCell	TCGA-Breast-Metastatic-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	OIT3 ITIH1 SHISA3	5.19e-04	149	47	3	2e9b898f3df22f8e872f2c278eff454c39e55b3b
ToppCell	TCGA-Breast-Metastatic\|TCGA-Breast / Sample_Type by Project: Shred V9	OIT3 ITIH1 SHISA3	5.19e-04	149	47	3	144ac2c458209ce510674bc2f83eb4c8e4d3c953
ToppCell	TCGA-Breast-Metastatic-Breast_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	OIT3 ITIH1 SHISA3	5.19e-04	149	47	3	c7dc495141cd921b6b6f291a68851b7b807d0d0a
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TDRD10 ALOXE3 CFAP44	5.29e-04	150	47	3	9cb3332924bd67c966873343c14445e30d3f384f
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPT2 DSE SHISA3	5.93e-04	156	47	3	5caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPT2 DSE SHISA3	5.93e-04	156	47	3	758f57dc10fc5cad200bf5b310c10ec9b1405f23
ToppCell	facs-Marrow-KLS-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPT2 USP28 PRKAB2	6.04e-04	157	47	3	5d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCell	facs-Marrow-KLS-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPT2 USP28 PRKAB2	6.04e-04	157	47	3	ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PZP SFMBT2 SHISA3	6.04e-04	157	47	3	1f21d78a467fe22c5ab75d0917b840c1ac93f32c
ToppCell	facs-Liver\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OIT3 PZP ITIH1	6.15e-04	158	47	3	ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-7\|TCGA-Cervix / Sample_Type by Project: Shred V9	MUC5B CAPN5 TMEM63A	6.27e-04	159	47	3	75a82bbabd97b168dbf1c3f43a9bdad48ce18c78
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYO9B DSE VCAN	6.50e-04	161	47	3	4362fe0c151f49eae7372b9673bac64d980a8389
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid\|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)	BTNL8 SFMBT2 IPO11	6.50e-04	161	47	3	1b5ebc82ee6166ecc2984648565f334cd69b636b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PZP ADGRG4 SHISA3	6.61e-04	162	47	3	3b89c3758835b7b9f9d4fb0bc8ed06da382fe48b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PPT2 PZP ADGRG4	6.85e-04	164	47	3	ed7277f8980f96f5b3e4eed025d46d0942e123d7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PPT2 PZP ADGRG4	6.85e-04	164	47	3	c4ad98106e8663caf7c1c15d30ec633d8bd8cf57
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	CTSZ VCAN ZNF461	6.85e-04	164	47	3	057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 SSC4D SEC14L1	7.22e-04	167	47	3	a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCell	VE-Treg-exh_CD4\|VE / Condition, Cell_class and T cell subcluster	CARS2 PRKAB1 TMEM63A	7.22e-04	167	47	3	1036ac1ef9440612500137af9d1929672b077e4d
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 SSC4D SEC14L1	7.22e-04	167	47	3	528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PELI1 OAS3 DSE	7.48e-04	169	47	3	2de213b083f57f47be58427c0ce127fee9f85caa
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PELI1 SFMBT2 CTSZ	7.48e-04	169	47	3	0867528101767fc65e93b3561480bf830c50368d
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CTSZ DSE VCAN	7.61e-04	170	47	3	9ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	MUC5B CAPN5 TMEM63A	7.61e-04	170	47	3	d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCell	Control-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	OAS3 EIF2AK2 DSE	7.61e-04	170	47	3	9e328e1f904c77dcce8aee4df775d7f0ac725775
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	MUC5B CAPN5 TMEM63A	7.74e-04	171	47	3	1af575809b3334bfaa019ff26c56e6cb03c82ee8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OAS3 BTNL8 CTSZ	8.00e-04	173	47	3	8407c9156ab35900858de5273586129d7e283c5b
ToppCell	PND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAPN5 FHL3 IPO11	8.13e-04	174	47	3	a3f4981b10afa9d41a1c66c7f98522a8a534f82b
ToppCell	PND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAPN5 FHL3 IPO11	8.13e-04	174	47	3	6cc108dde4b3f98a78a6040280f0d5e4aaa5bd75
ToppCell	PND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAPN5 FHL3 IPO11	8.13e-04	174	47	3	4b8bc5568e36031c8ecf001bb646809038c23919
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYO9B CTSZ VCAN	8.13e-04	174	47	3	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	OAS3 MYO9B EIF2AK2	8.27e-04	175	47	3	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	SFMBT2 CTSZ VCAN	8.27e-04	175	47	3	d3890bd0c570bb81434fdd1c5229891cefe2e462
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_MT-positive-Alveolar_macrophage_MT-positive_L.1.0.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC4D CD163L1 CTSZ	8.27e-04	175	47	3	b227d4499274fb63b193d34de7f2d812e283e79d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_MT-positive\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC4D CD163L1 CTSZ	8.27e-04	175	47	3	308ee4ef7b9ecea68efca011ef91aed0f1be0eca
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 DSE VCAN	8.27e-04	175	47	3	1d1cdbf3221b03e24eae38afd57cbd6736b37a53
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	OAS3 MYO9B EIF2AK2	8.27e-04	175	47	3	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 DSE VCAN	8.27e-04	175	47	3	d67c77eee979ad029e7545f383326f0ff77c6e5f
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MUC5B VCAN PRKAB2	8.41e-04	176	47	3	91ad2c34144f72283ca112fd3b3784f2f6259f65
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	HERC1 SHANK2 FBXW7	8.41e-04	176	47	3	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TDRD10 BTNL8 SEC14L1	8.41e-04	176	47	3	dc5a22f9d1347f157bdd93e6e5769b983deccf1a
ToppCell	PND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OIT3 IPO11 PRKAB2	8.69e-04	178	47	3	aa659bd283c4dfbe292cd8698bbf6b1999ca3314
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PELI1 SFMBT2 FBXW7	8.69e-04	178	47	3	f815bc76f98aaea2d9058173b02b6f36e45283ce
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PELI1 SFMBT2 FBXW7	8.69e-04	178	47	3	a0334764e865fea652c54b94bbc3b173f7cbc9fc
ToppCell	PND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OIT3 IPO11 PRKAB2	8.69e-04	178	47	3	9e1f2596fcea5b79cc50b58d83706bb8605e224f
ToppCell	PND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OIT3 IPO11 PRKAB2	8.69e-04	178	47	3	bf1d273802a4f42e52ea1bd2a0cae2039559c093
ToppCell	PND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GANAB IPO11 PRKAB2	8.83e-04	179	47	3	362c003503190dc272fa89185a83a65e063d7a67
ToppCell	PND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GANAB IPO11 PRKAB2	8.83e-04	179	47	3	7d2e6bde00a9ab4cb21bd48b140ce205e36f9d77
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OAS3 EIF2AK2 CTSZ	8.83e-04	179	47	3	06d412fc096d88de168969466ce422f0ab5553b2
ToppCell	PND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GANAB IPO11 PRKAB2	8.83e-04	179	47	3	e0eec8d48868c76c3e879f219357c62ceff1bc76
ToppCell	Control-Myeloid-Dendritic_cells\|Control / group, cell type (main and fine annotations)	MYO9B ITIH1 SFMBT2	8.97e-04	180	47	3	25ad95c3c30e3b82abe93bd77ba003f5c2241f7c
ToppCell	mild_COVID-19_(asymptomatic)-cDC\|World / disease group, cell group and cell class (v2)	OAS3 MALT1 DSE	8.97e-04	180	47	3	68d1c867734fb2977b01ac686b20bf602f9a6b72
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN5 USP28 CD163L1	8.97e-04	180	47	3	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BTNL8 ADGRG4 CTSZ	9.12e-04	181	47	3	1d3d1b5a6efe9cedd03b7e0b5684df97f0246729
Drug	Flunixin meglumine [42461-84-7]; Down 200; 8.2uM; PC3; HT_HG-U133A	CFAP44 SEC14L1 PRKAB2 TMEM63A FBXW7	4.54e-05	191	47	5	4273_DN
Drug	clozapine; Down 200; 10uM; HL60; HT_HG-U133A	CAPN5 MYO9B CLN5 SEC14L1 TMEM63A	4.66e-05	192	47	5	6188_DN
Drug	(-)-depudecin; Up 200; 1uM; MCF7; HT_HG-U133A_EA	OAS3 SYNRG SLC25A12 MYO9B TMEM63A	4.77e-05	193	47	5	982_UP
Drug	Dipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	CAPN5 GANAB CFAP44 MYO9B TMEM63A	5.14e-05	196	47	5	7124_DN
Drug	Chloropyramine hydrochloride [6170-42-9]; Down 200; 12.2uM; MCF7; HT_HG-U133A	SYNRG CAPN5 PRKAB1 SEC14L1 TMEM63A	5.14e-05	196	47	5	3350_DN
Drug	Trolox [53188-07-1]; Down 200; 16uM; MCF7; HT_HG-U133A	MALT1 CFAP44 MYO9B CTSZ TMEM63A	5.14e-05	196	47	5	6007_DN
Drug	aspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A	CFAP44 MYO9B CLN5 SEC14L1 FBXW7	5.26e-05	197	47	5	1145_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HG-U133A	MALT1 GANAB SLC25A12 MYO9B EIF2AK2	5.26e-05	197	47	5	203_UP
Drug	Methantheline bromide [53-46-3]; Down 200; 9.6uM; PC3; HT_HG-U133A	PELI1 CTSZ VCAN SEC14L1 TMEM63A	5.26e-05	197	47	5	5780_DN
Drug	Nitrofurantoin [67-20-9]; Down 200; 16.8uM; HL60; HT_HG-U133A	MYO9B EIF2AK2 DSE SEC14L1 TMEM63A	5.26e-05	197	47	5	2341_DN
Drug	Sulindac [38194-50-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	MALT1 SHANK2 CARS2 CLN5 TMEM63A	5.26e-05	197	47	5	1693_DN
Drug	STOCK1N-35696; Down 200; 15uM; MCF7; HT_HG-U133A	OAS3 SLC25A12 CFAP44 VCAN TMEM63A	5.26e-05	197	47	5	6577_DN
Drug	raloxifene hydrochloride; Up 200; 0.1uM; MCF7; HG-U133A	MALT1 GANAB SLC25A12 EIF2AK2 SEC14L1	5.26e-05	197	47	5	202_UP
Disease	autistic disorder (is_implicated_in)	SLC25A12 SHANK2	1.97e-03	42	46	2	DOID:12849 (is_implicated_in)
Disease	eosinophilic esophagitis	CAPN5 SHANK2 SH3RF1	2.11e-03	163	46	3	EFO_0004232
Disease	Influenza	OAS3 EIF2AK2	3.00e-03	52	46	2	C0021400

Protein segments in the cluster

Peptide	Gene	Start	Entry
HENGQWNDVPCNYHL	VCAN	3271	P13611
WDYAHQHGIPDETCN	CTSZ	141	Q9UBR2
FQAGKHYWEVDGGHN	BTNL8	336	Q6UX41
GNQNYGQVHCAFWDF	ADGRG4	2676	Q8IZF6
GEHQYKFFVDGQWVH	PRKAB2	121	O43741
HDLHQGQVGNCWFVA	CAPN5	71	O15484
EWGSHNCYHGEDVGV	CD163L1	131	Q9NR16
NYRGFDIGNHFCEWV	CHKB	271	Q9Y259
DIGNHFCEWVYDYTH	CHKB	276	Q9Y259
VDYWHFNMHDNNYGC	CFAP44	846	Q96MT7
AHNGRVCSTWGDFHY	MUC5B	71	Q9HC84
LCFHYSWVAEDHQGA	PZP	426	P20742
HGAEVSCWFIHNNGA	ITIH1	881	P19827
DLEHQGTYWCHVYND	MALT1	281	Q9UDY8
EHWCEDHFFGYQYLN	ALOXE3	266	Q9BYJ1
GIYNFACSLWNHHTD	IPO11	176	Q9UI26
HCLALSHDNEVYAWG	HERC1	676	Q15751
CDNHVNGEWYHFTGM	OIT3	51	Q8WWZ8
GWGFQYLHNHQPTNC	DSE	196	Q9UL01
WCGEDAIHYLSFQRH	TMEM63A	131	O94886
QEFSICNYWHDPHHD	PPT2	171	Q9UMR5
EYGGQTWHEHCFLCS	FHL3	116	Q13643
WDVHHGQGIQYLFED	HDAC10	171	Q969S8
DHVNIVHYNGCWDGF	EIF2AK2	316	P19525
WNAETGECIHTLYGH	FBXW7	446	Q969H0
QVLQDYYAGGWHHHD	SEC14L1	321	Q92503
WVYLNCGHVHGYHNW	PELI1	306	Q96FA3
CGHVHGYHNWGNKEE	PELI1	311	Q96FA3
QHQHLCVFWTVNYGF	OAS3	261	Q9Y6K5
QYLEQHASGRFHCSW	RTP2	46	Q5QGT7
EVFHQCEQWGNYFLH	CARS2	291	Q9HA77
GHQYHASCANFWINC	SYNRG	1286	Q9UMZ2
CLAEYHLGDYGHAWN	TDRD10	251	Q5VZ19
QHYGGWEHRDVHNIY	GANAB	561	Q14697
EYCHGWVDVQGNYHE	SHISA3	26	A0PJX4
WVDVQGNYHEGFQCP	SHISA3	31	A0PJX4
QVDENWYHGEVNGIH	SH3RF1	166	Q7Z6J0
ENGWHEIHQACRYGH	SHANK2	296	Q9UPX8
GEHQYKFFVDGQWTH	PRKAB1	121	Q9Y478
QGAACFFEGIDDVHW	CLN5	161	O75503
FNWDCEFIRLHFGHN	SLC25A12	126	O75746
HVGGPEQNNHVCYWE	ZIC3	286	O60481
CVHTFFDHQDQVWGV	WDR61	266	Q9GZS3
GWGVHNCFHYEDVAV	SSC4D	141	Q8WTU2
SGQDFDWADYHKQHG	SFMBT2	376	Q5VUG0
VLVHEGQANAGHYWA	USP25	596	Q9UHP3
GQANAGHYWAYIFDH	USP25	601	Q9UHP3
VHEGQANAGHYWAYI	USP28	591	Q96RU2
WQVSLHFDHNFICGG	PRSS48	41	Q7RTY5
FSAIWEGNCHFEQHQ	ZNF461	141	Q8TAF7
HVGGPEQSNHVCFWE	ZIC2	291	O95409
TWHNIGYTDNVGCIH	MYO9B	566	Q13459