Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of microtubule polymerization	PAK1 DYRK1A APC SNCA CAMSAP1	1.86e-06	69	61	5	GO:0031113
GeneOntologyBiologicalProcess	negative regulation of microtubule polymerization or depolymerization	DYRK1A APC SNCA CAMSAP1	1.56e-05	51	61	4	GO:0031111
GeneOntologyBiologicalProcess	RNA splicing	CCNL2 KAT2B ZRANB2 NUP98 RBM42 DYRK1A SCAF11 SF3A2 DHX9	1.57e-05	502	61	9	GO:0008380
GeneOntologyBiologicalProcess	regulation of microtubule polymerization or depolymerization	PAK1 DYRK1A APC SNCA CAMSAP1	1.69e-05	108	61	5	GO:0031110
GeneOntologyBiologicalProcess	regulation of microtubule-based process	CCNL2 KAT2B PAK1 DYRK1A APC SNCA CAMSAP1	2.46e-05	293	61	7	GO:0032886
GeneOntologyBiologicalProcess	microtubule polymerization	PAK1 DYRK1A APC SNCA CAMSAP1	2.49e-05	117	61	5	GO:0046785
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	DNAAF2 CCNL2 FLNA KAT2B CCSER2 PAK1 DYRK1A APC SNCA CAMSAP1	4.55e-05	720	61	10	GO:0000226
GeneOntologyBiologicalProcess	protein polymerization	PAK1 DYRK1A APC PAK3 SNCA CAMSAP1 CRP	5.65e-05	334	61	7	GO:0051258
GeneOntologyBiologicalProcess	regulation of protein polymerization	PAK1 DYRK1A APC PAK3 SNCA CAMSAP1	6.14e-05	231	61	6	GO:0032271
GeneOntologyBiologicalProcess	positive regulation of fibroblast migration	PAK1 APC PAK3	6.84e-05	27	61	3	GO:0010763
GeneOntologyBiologicalProcess	positive regulation of cell projection organization	FLNA KAT2B BMPR2 PAK1 APC PAK3 SF3A2 CRP	9.89e-05	494	61	8	GO:0031346
GeneOntologyBiologicalProcess	microtubule polymerization or depolymerization	PAK1 DYRK1A APC SNCA CAMSAP1	1.39e-04	168	61	5	GO:0031109
GeneOntologyBiologicalProcess	regulation of microtubule cytoskeleton organization	PAK1 DYRK1A APC SNCA CAMSAP1	1.73e-04	176	61	5	GO:0070507
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein kinase activity	KAT2B APC STOX1 CDC25C	2.20e-04	100	61	4	GO:1904029
GeneOntologyBiologicalProcess	protein localization to cytoplasmic stress granule	PAK1 DHX9	2.38e-04	8	61	2	GO:1903608
GeneOntologyBiologicalProcess	microtubule-based process	DNAAF2 CCNL2 FLNA KAT2B CCSER2 PAK1 DYRK1A APC SYBU SNCA CAMSAP1	2.42e-04	1058	61	11	GO:0007017
GeneOntologyBiologicalProcess	negative regulation of cytoskeleton organization	KAT2B DYRK1A APC SNCA CAMSAP1	2.71e-04	194	61	5	GO:0051494
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	FLNA KAT2B PAK1 DYRK1A APC PAK3 SNCA CAMSAP1	2.92e-04	579	61	8	GO:0051493
GeneOntologyBiologicalProcess	regulation of supramolecular fiber organization	FLNA PAK1 DYRK1A APC PAK3 SNCA CAMSAP1	3.01e-04	438	61	7	GO:1902903
GeneOntologyBiologicalProcess	protein deacetylation	FLNA KAT2B DYRK1A	3.64e-04	47	61	3	GO:0006476
GeneOntologyBiologicalProcess	regulation of RNA splicing	CCNL2 KAT2B NUP98 RBM42 DYRK1A	3.66e-04	207	61	5	GO:0043484
GeneOntologyCellularComponent	condensed chromosome, centromeric region	KAT2B ZNF276 NUP98 APC SYCP3	2.69e-04	193	62	5	GO:0000779
GeneOntologyCellularComponent	supramolecular fiber	FLNA KAT2B KRT222 PAK1 DYRK1A APC SYBU SNCA CAMSAP1 NEXN MYBPC2	6.27e-04	1179	62	11	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	FLNA KAT2B KRT222 PAK1 DYRK1A APC SYBU SNCA CAMSAP1 NEXN MYBPC2	6.63e-04	1187	62	11	GO:0099081
GeneOntologyCellularComponent	growth cone	FLNA PAK1 APC SNCA CRP	7.97e-04	245	62	5	GO:0030426
GeneOntologyCellularComponent	sarcomere	FLNA KAT2B PAK1 NEXN MYBPC2	8.57e-04	249	62	5	GO:0030017
GeneOntologyCellularComponent	site of polarized growth	FLNA PAK1 APC SNCA CRP	9.21e-04	253	62	5	GO:0030427
GeneOntologyCellularComponent	axon	FLNA BMPR2 PAK1 DYRK1A APC SYBU SNCA NEXN CRP	1.19e-03	891	62	9	GO:0030424
GeneOntologyCellularComponent	myofibril	FLNA KAT2B PAK1 NEXN MYBPC2	1.29e-03	273	62	5	GO:0030016
GeneOntologyCellularComponent	nuclear body	CCNL2 PSMB7 NUP98 DYRK1A ELF2 ELF4 SCAF11 SF3A2 DHX9	1.31e-03	903	62	9	GO:0016604
GeneOntologyCellularComponent	chromosome, centromeric region	KAT2B ZNF276 NUP98 APC SYCP3	1.36e-03	276	62	5	GO:0000775
GeneOntologyCellularComponent	I band	FLNA KAT2B PAK1 NEXN	1.50e-03	166	62	4	GO:0031674
GeneOntologyCellularComponent	actin cytoskeleton	FLNA KAT2B PAK1 DYRK1A SNCA NEXN DHX9	1.54e-03	576	62	7	GO:0015629
GeneOntologyCellularComponent	contractile muscle fiber	FLNA KAT2B PAK1 NEXN MYBPC2	1.68e-03	290	62	5	GO:0043292
GeneOntologyCellularComponent	kinetochore	KAT2B ZNF276 NUP98 APC	2.05e-03	181	62	4	GO:0000776
GeneOntologyCellularComponent	condensed chromosome	KAT2B ZNF276 NUP98 APC SYCP3	2.16e-03	307	62	5	GO:0000793
Domain	Elf-1_N	ELF2 ELF4	3.35e-05	3	63	2	PF12310
Domain	TF_Elf_N	ELF2 ELF4	3.35e-05	3	63	2	IPR022084
Domain	CPSASE_2	MCCC1 CPS1	1.67e-04	6	63	2	PS00867
Domain	PAK_BD	PAK1 PAK3	1.67e-04	6	63	2	IPR033923
Domain	CPSase_L_D2	MCCC1 CPS1	2.33e-04	7	63	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	MCCC1 CPS1	2.33e-04	7	63	2	IPR005479
Domain	BC-like_N	MCCC1 CPS1	2.33e-04	7	63	2	IPR005481
Domain	Biotin_carb_N	MCCC1 CPS1	2.33e-04	7	63	2	PF00289
Domain	-	PAK1 PAK3	7.23e-04	12	63	2	3.90.810.10
Domain	-	MCCC1 CPS1	8.53e-04	13	63	2	3.40.50.20
Domain	ATP-grasp	MCCC1 CPS1	9.93e-04	14	63	2	IPR011761
Domain	PreATP-grasp_dom	MCCC1 CPS1	9.93e-04	14	63	2	IPR016185
Domain	ATP_GRASP	MCCC1 CPS1	9.93e-04	14	63	2	PS50975
Domain	-	MCCC1 CPS1	1.14e-03	15	63	2	3.30.1490.20
Domain	PBD	PAK1 PAK3	1.30e-03	16	63	2	SM00285
Domain	PBD	PAK1 PAK3	1.47e-03	17	63	2	PF00786
Domain	ATP_grasp_subdomain_1	MCCC1 CPS1	1.65e-03	18	63	2	IPR013815
Domain	-	MCCC1 CPS1	1.65e-03	18	63	2	3.30.470.20
Domain	CRIB	PAK1 PAK3	2.05e-03	20	63	2	PS50108
Domain	CRIB_dom	PAK1 PAK3	2.26e-03	21	63	2	IPR000095
Domain	ETS_DOMAIN_1	ELF2 ELF4	4.00e-03	28	63	2	PS00345
Domain	ETS_DOMAIN_2	ELF2 ELF4	4.00e-03	28	63	2	PS00346
Domain	ETS	ELF2 ELF4	4.00e-03	28	63	2	SM00413
Domain	Ets_dom	ELF2 ELF4	4.00e-03	28	63	2	IPR000418
Domain	ETS_DOMAIN_3	ELF2 ELF4	4.00e-03	28	63	2	PS50061
Domain	Ets	ELF2 ELF4	4.00e-03	28	63	2	PF00178
Domain	ATP_grasp_subdomain_2	MCCC1 CPS1	4.89e-03	31	63	2	IPR013816
Domain	Kringle-like	IGF2R LPA	5.20e-03	32	63	2	IPR013806
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	FLNA PAK1 PAK3	5.34e-05	21	50	3	M27494
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	FLNA PAK1 PAK3	7.07e-05	23	50	3	MM15222
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	BMPR2 ESYT1 MAZ CCSER2 XRN1 DYRK1A APC MCCC1 CAMSAP1 CDC25C NUAK2	4.52e-07	861	64	11	36931259
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ATP5PF ZNF276 MAZ NUP98 RBM42 SRP14 ELF2 ELF4 SCAF11 MCCC1 SF3A2 CASZ1 DHX9	5.54e-07	1294	64	13	30804502
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ESYT1 CCSER2 NUP98 DYRK1A APC SRP14 CAMSAP1 DHX9	1.47e-06	440	64	8	34244565
Pubmed	Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins.	PAK3 SNCA ADAP2	2.66e-06	15	64	3	18541383
Pubmed	The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin L2 To Control HIV Replication in Macrophages.	CCNL2 DYRK1A	3.33e-06	2	64	2	31852782
Pubmed	Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A.	FLNA PAK1	3.33e-06	2	64	2	23340249
Pubmed	p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.	PAK1 PAK3	3.33e-06	2	64	2	21115725
Pubmed	Vibrio vulnificus RtxA1 cytotoxin targets filamin A to regulate PAK1- and MAPK-dependent cytoskeleton reorganization and cell death.	FLNA PAK1	3.33e-06	2	64	2	31237474
Pubmed	PAK1 promotes intestinal tumor initiation.	PAK1 APC	3.33e-06	2	64	2	26304465
Pubmed	Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.	PAK1 APC	3.33e-06	2	64	2	28629331
Pubmed	Filamin A stimulates cdc25C function and promotes entry into mitosis.	FLNA CDC25C	3.33e-06	2	64	2	21325883
Pubmed	The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.	PAK1 PAK3	3.33e-06	2	64	2	22815483
Pubmed	Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1.	FLNA PAK1	3.33e-06	2	64	2	12198493
Pubmed	Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.	PAK1 PAK3	3.33e-06	2	64	2	23622267
Pubmed	Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.	PAK1 PAK3	3.33e-06	2	64	2	30858169
Pubmed	Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.	PAK1 PAK3	3.33e-06	2	64	2	27474226
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	FLNA ESYT1 PSMB7 XRN1 PAK1 SNCA FKBP3 DHX9	3.66e-06	498	64	8	36634849
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	DNAAF2 ATP5PF ABCA13 NUP98 XRN1 HSPA1L SF3A2 DHX9	4.55e-06	513	64	8	25798074
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	FLNA IGF2R ESYT1 ZRANB2 NUP98 MACROD1 PAK1 MCCC1 NEXN HSPA1L SF3A2 FKBP3	6.41e-06	1367	64	12	32687490
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TSR1 MAZ DYRK1A APC HSPA1L CASZ1 DHX9	8.64e-06	398	64	7	35016035
Pubmed	Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.	PAK1 PAK3	9.99e-06	3	64	2	15182717
Pubmed	Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.	DYRK1A SNCA	9.99e-06	3	64	2	16959772
Pubmed	The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.	PAK1 PAK3	9.99e-06	3	64	2	9823899
Pubmed	PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.	PAK1 PAK3	9.99e-06	3	64	2	29860311
Pubmed	Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9.	NUP98 DHX9	9.99e-06	3	64	2	28221134
Pubmed	Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.	PAK1 PAK3	9.99e-06	3	64	2	10075701
Pubmed	The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.	PAK1 PAK3	9.99e-06	3	64	2	23335370
Pubmed	Group I Paks as therapeutic targets in NF2-deficient meningioma.	PAK1 PAK3	9.99e-06	3	64	2	25596744
Pubmed	The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.	PAK1 PAK3	9.99e-06	3	64	2	18507705
Pubmed	P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α.	PAK1 APC	9.99e-06	3	64	2	23811286
Pubmed	Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.	PAK1 PAK3	9.99e-06	3	64	2	38785043
Pubmed	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.	PAK1 PAK3	9.99e-06	3	64	2	11278486
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	FLNA KAT2B TSR1 MAZ ZRANB2 PSMB7 RBM42 SRP14 HSPA1L DHX9	1.06e-05	971	64	10	33306668
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CA12 FLNA IGF2R GPX8 ESYT1 MAZ CCSER2 DYRK1A SF3A2 CASZ1 DHX9	1.12e-05	1203	64	11	29180619
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	IGF2R ESYT1 ZRANB2 NUP98 XRN1 APC MCCC1 CAMSAP1 DHX9	1.22e-05	777	64	9	35844135
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FLNA TSR1 ESYT1 MAZ ZRANB2 SRP14 SCAF11 MCCC1 SF3A2 DHX9	1.24e-05	989	64	10	36424410
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TSR1 ESYT1 MAZ ZRANB2 XRN1 RBM42 DYRK1A APC SCAF11 SF3A2 FKBP3 CASZ1	1.59e-05	1497	64	12	31527615
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FLNA IGF2R TSR1 ESYT1 APC SRP14 SF3A2 FKBP3 DHX9	1.67e-05	809	64	9	32129710
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	IGF2R TSR1 ESYT1 RBM42 DYRK1A DHX9	1.93e-05	300	64	6	28561026
Pubmed	PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.	PAK1 PAK3	2.00e-05	4	64	2	9659915
Pubmed	A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.	PAK1 PAK3	2.00e-05	4	64	2	7493928
Pubmed	Pak to the future.	PAK1 PAK3	2.00e-05	4	64	2	10461188
Pubmed	Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.	APC CPS1	2.00e-05	4	64	2	29426940
Pubmed	Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease.	LPA SNCA	2.00e-05	4	64	2	38615036
Pubmed	A brain serine/threonine protein kinase activated by Cdc42 and Rac1.	PAK1 PAK3	2.00e-05	4	64	2	8107774
Pubmed	CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.	PAK1 PAK3	2.00e-05	4	64	2	19819308
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	FLNA ESYT1 CPS1 HSPA1L DHX9	2.04e-05	179	64	5	36261009
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	TSR1 ZRANB2 NUP98 SRP14 SCAF11 SYBU CPS1 SF3A2 DHX9	2.40e-05	847	64	9	35850772
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	IGF2R TSR1 ESYT1 XRN1 DYRK1A APC MCCC1 SNCA CAMSAP1	2.54e-05	853	64	9	28718761
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	NT5C2 SRP14 NEXN FKBP3	2.58e-05	92	64	4	15840729
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	ESYT1 APC CPS1 CDC25C DHX9	2.71e-05	190	64	5	15161933
Pubmed	Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.	IGF2R LPA	3.32e-05	5	64	2	21273553
Pubmed	Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.	ELF2 ELF4	3.32e-05	5	64	2	10207087
Pubmed	Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression.	IGF2R APC	3.32e-05	5	64	2	31388182
Pubmed	Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.	PAK1 PAK3	3.32e-05	5	64	2	23509247
Pubmed	The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters.	IGF2R LPA	3.32e-05	5	64	2	8854860
Pubmed	SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.	MCCC1 SNCA	3.32e-05	5	64	2	32652860
Pubmed	Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.	PAK1 APC	4.98e-05	6	64	2	16368433
Pubmed	The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.	PAK1 APC	4.98e-05	6	64	2	19893577
Pubmed	Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.	PAK1 PAK3	4.98e-05	6	64	2	10205168
Pubmed	Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.	PAK1 PAK3	4.98e-05	6	64	2	12237306
Pubmed	Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.	PAK1 PAK3	4.98e-05	6	64	2	33482876
Pubmed	Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.	ELF2 ELF4	4.98e-05	6	64	2	14970218
Pubmed	Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons.	PAK1 PAK3	4.98e-05	6	64	2	12213441
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FLNA DDX60 MAZ XRN1 APC MCCC1 CAMSAP1 FKBP3	5.37e-05	724	64	8	36232890
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	FLNA TSR1 PSMB7 SRP14 NEXN SF3A2 DHX9	5.91e-05	538	64	7	28524877
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	FLNA MAZ NUP98 SRP14 ELF2 SCAF11 MCCC1 FKBP3 DHX9	6.03e-05	954	64	9	36373674
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FLNA IGF2R GPX8 ESYT1 MACROD1 NT5C2 DYRK1A SNX33 MCCC1 SF3A2 CRP	6.24e-05	1451	64	11	30550785
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FLNA TSR1 ZRANB2 PSMB7 NUP98 NT5C2 SRP14 SNCA HSPA1L FKBP3 DHX9	6.39e-05	1455	64	11	22863883
Pubmed	Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.	PAK1 PAK3	6.96e-05	7	64	2	25981171
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	NUP98 ELF2 ELF4 CCDC168	8.03e-05	123	64	4	26912792
Pubmed	Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.	IGF2R LPA	9.27e-05	8	64	2	9438420
Pubmed	Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.	IGF2R LPA	9.27e-05	8	64	2	11562346
Pubmed	The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.	IGF2R LPA	9.27e-05	8	64	2	1845916
Pubmed	Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.	IGF2R LPA	9.27e-05	8	64	2	16204191
Pubmed	Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors.	MAZ PSMB7	9.27e-05	8	64	2	9986727
Pubmed	Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton.	CCSER2 APC NEXN	9.69e-05	48	64	3	27872092
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	FLNA TSR1 MAZ DYRK1A SRP14 SF3A2 DHX9	9.75e-05	583	64	7	29844126
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	FLNA ESYT1 NUP98 XRN1 APC	1.11e-04	256	64	5	33397691
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	FLNA MAZ ZRANB2 XRN1 SRP14 SCAF11 SF3A2 DHX9	1.14e-04	807	64	8	22681889
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	FLNA ESYT1 MACROD1 NT5C2 MCCC1 HSPA1L FKBP3 DHX9	1.14e-04	807	64	8	30575818
Pubmed	Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation.	IGF2R LPA	1.19e-04	9	64	2	25918552
Pubmed	Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development.	FLNA CASZ1	1.19e-04	9	64	2	25953344
Pubmed	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	CCNL2 DYRK1A	1.19e-04	9	64	2	14623875
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	FLNA IGF2R TSR1 GPX8 ESYT1 MAZ NT5C2 APC SF3A2 DHX9	1.22e-04	1297	64	10	33545068
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ESYT1 CCSER2 XRN1 APC CAMSAP1	1.26e-04	263	64	5	34702444
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	IGF2R MAZ ZRANB2 MED26 FKBP3 DHX9	1.32e-04	425	64	6	24999758
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	FLNA XRN1 SRP14 CPS1 HSPA1L DHX9	1.32e-04	425	64	6	21081503
Pubmed	EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.	KAT2B APC	1.49e-04	10	64	2	23001180
Pubmed	Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.	NUP98 APC	1.49e-04	10	64	2	26731471
Pubmed	Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms.	IGF2R APC	1.49e-04	10	64	2	8706013
Pubmed	LINC00152 Promotes Tumor Progression and Predicts Poor Prognosis by Stabilizing BCL6 From Degradation in the Epithelial Ovarian Cancer.	HSPA1L DHX9	1.49e-04	10	64	2	33282727
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TSR1 MAZ ZRANB2 RBM42 APC SRP14 SF3A2 FKBP3 DHX9	1.57e-04	1082	64	9	38697112
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	FLNA PAK1 ELF2 MCCC1 CPS1 MED26	1.68e-04	444	64	6	34795231
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	MAZ PSMB7 XRN1 RBM42 SF3A2	1.72e-04	281	64	5	24163370
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNA GPX8 ESYT1 XRN1 SRP14 SNX33 MCCC1 NEXN HSPA1L DHX9	1.72e-04	1353	64	10	29467282
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ESYT1 NUP98 DYRK1A SNX33 CPS1 CAMSAP1 HSPA1L CASZ1	1.72e-04	857	64	8	25609649
Pubmed	Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene.	IGF2R LPA	1.81e-04	11	64	2	9268631
Pubmed	Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.	BMPR2 TSR1	1.81e-04	11	64	2	7791754
Pubmed	Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.	APC CPS1	1.81e-04	11	64	2	20084116
Interaction	SNCA interactions	DNAAF2 FLNA KAT2B ESYT1 XRN1 PAK1 DYRK1A PAK3 SNCA HSPA1L FKBP3 ADAP2 DHX9	3.18e-07	716	64	13	int:SNCA
Interaction	MAPRE1 interactions	FLNA KAT2B CCSER2 NUP98 APC SYBU SNCA CAMSAP1 MED26 NEXN	4.70e-06	514	64	10	int:MAPRE1
Interaction	CSNK2A1 interactions	CCNL2 KAT2B IGF2R TSR1 MAZ ZRANB2 NUP98 PAK1 APC ANKRD36 SNCA CDC25C FKBP3	7.85e-06	956	64	13	int:CSNK2A1
Interaction	CALM1 interactions	DNAAF2 FLNA XRN1 NT5C2 SRP14 ELF2 SCAF11 SNCA NEXN FKBP3	2.60e-05	626	64	10	int:CALM1
Interaction	SIRT6 interactions	FLNA ESYT1 CCSER2 NUP98 DYRK1A APC SRP14 CAMSAP1 HSPA1L DHX9	2.67e-05	628	64	10	int:SIRT6
Interaction	YWHAE interactions	FLNA ESYT1 CCSER2 ZRANB2 NT5C2 DYRK1A APC SCAF11 SNX33 SNCA CAMSAP1 CDC25C DHX9 NUAK2	3.14e-05	1256	64	14	int:YWHAE
Interaction	FZR1 interactions	FLNA KAT2B TSR1 MAZ ZRANB2 PSMB7 NUP98 RBM42 DYRK1A SRP14 HSPA1L DHX9 MYBPC2	6.66e-05	1172	64	13	int:FZR1
Cytoband	6q26	IGF2R LPA	2.89e-04	18	64	2	6q26
Cytoband	15q22	CA12 SRP14	7.58e-04	29	64	2	15q22
ToppCell	PBMC-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	DDX60 ZRANB2 PAK1 SRP14 SCAF11 NEXN	3.73e-07	195	64	6	674355ca00314bde90ef7f6ddb83afe2d5323130
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMPR2 COL6A6 XRN1 SCAF11 NEXN MYBPC2	3.73e-07	195	64	6	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RALGPS1 PAK1 SNX33 HSPA1L NUAK2	2.43e-06	149	64	5	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RALGPS1 PAK1 SNX33 HSPA1L NUAK2	2.51e-06	150	64	5	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	IKZF2 XRN1 NT5C2 CAMSAP1 NUAK2	5.32e-06	175	64	5	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	BMPR2 CCSER2 APC SCAF11 HEATR5A	7.16e-06	186	64	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA COL6A6 ADAMTS2 NEXN ITIH3	8.35e-06	192	64	5	26d9207e72bbef5e0046de511e2c9ff752b726f3
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA COL6A6 ADAMTS2 NEXN ITIH3	8.56e-06	193	64	5	7fc3ab7261c88c1df71744bf5b17e8e46c4300e0
ToppCell	PBMC-Mild\|PBMC / Compartment, Disease Groups and Clusters	FLNA ZNF276 DDX60 ELF2 NEXN	8.78e-06	194	64	5	d1366b169d14011194e61d16b6b0953349febc78
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLNA DDX60 SKAP1 CCSER2 XRN1	1.02e-05	200	64	5	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	FLNA KAT2B IKZF2 IGF2R DDX60	1.02e-05	200	64	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	metastatic_Brain-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	FLNA PAK3 HSPA1L CASZ1	7.15e-05	154	64	4	423f58fc7dcef068458cbf7b4ee989e37227041e
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high\|E18.5-samps / Age Group, Lineage, Cell class and subclass	DDX60 MACROD1 STOX1 CASZ1	7.15e-05	154	64	4	212c340a096a3a9669d1aebd61c045cf1402a868
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS2 PAK1 CPS1 HSPA1L	7.15e-05	154	64	4	874b1220337276489a89fcc9a39bc81ba6b68baf
ToppCell	ICU-SEP-Lymphocyte-T_NK-gdT\|ICU-SEP / Disease, Lineage and Cell Type	ZNF276 IKZF2 SKAP1 STOX1	8.29e-05	160	64	4	0a14b1fed54a09c0caf263662b5bd426466c7189
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	IKZF2 DDX60 MAZ SKAP1	8.91e-05	163	64	4	4dfd408aa700e307478ee35f6b902f68719d8d9e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAMTS2 TSR1 SKAP1 PAK1	9.12e-05	164	64	4	a5227971a71345854e0538e42da684de87febda0
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IKZF2 SKAP1 ELF4 ZNF80	1.00e-04	168	64	4	187b98664843a304406f086ea696adbf32283d07
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	IKZF2 SKAP1 ZNF80 ANKRD36	1.10e-04	172	64	4	9497948bbe53fb88c6ff6b347f743d456da587e5
ToppCell	COVID-19-kidney-PCT-S3-2\|kidney / Disease (COVID-19 only), tissue and cell type	LPA CPS1 ITIH3 CRP	1.15e-04	174	64	4	5aa2fb631505600f37d2b87b02def7be139dc262
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMPR2 XRN1 SCAF11 DHX9	1.20e-04	176	64	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LPA CPS1 ITIH3 CRP	1.20e-04	176	64	4	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	ESYT1 RALGPS1 SNX33 HSPA1L	1.28e-04	179	64	4	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 SKAP1 XRN1 DHX9	1.36e-04	182	64	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA COL6A6 NEXN ADAP2	1.36e-04	182	64	4	ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 SKAP1 XRN1 DHX9	1.36e-04	182	64	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	IKZF2 RALGPS1 RBM42 CCDC168	1.39e-04	183	64	4	3cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA COL6A6 NEXN ADAP2	1.42e-04	184	64	4	94748f63947db79a6b4540e3090a63689fdd9452
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 SKAP1 CPS1 CASZ1	1.42e-04	184	64	4	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN1 APC SCAF11 DHX9	1.42e-04	184	64	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA COL6A6 NEXN ADAP2	1.42e-04	184	64	4	819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CA12 FLNA GPX8 NEXN	1.42e-04	184	64	4	89302321b0949d5b57047b75dd16049aac9a2a3f
ToppCell	human_hepatoblastoma-NK.T_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	KAT2B IKZF2 SKAP1 ZNF80	1.54e-04	188	64	4	71b7599e7e1d63cc0c8518c0501533755951d58f
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FLNA PAK3 NEXN CASZ1	1.54e-04	188	64	4	74f7d216209cabdc96b2d46685b0ae017fdcc8fc
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 RALGPS1 SKAP1 CASZ1	1.54e-04	188	64	4	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	P07-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLNA COL6A6 ADAMTS2 ITIH3	1.54e-04	188	64	4	6ec22b79b19d57ea187f312907819dc2d01f3efe
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CPS1 SNCA ITIH3 CRP	1.57e-04	189	64	4	7899af78b273d9c7f029d52f7e0cf6df4da41f5e
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA INAFM2 NEXN CASZ1	1.61e-04	190	64	4	e102622f05c7f3e1bd8b224ea159d57033793ee0
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CPS1 SNCA ITIH3 CRP	1.61e-04	190	64	4	a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 RALGPS1 SKAP1 CASZ1	1.61e-04	190	64	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.64e-04	191	64	4	96ff4cfbdcaec4b8568f9482d732dddd399121d3
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	KAT2B PAK1 PAK3 ADAP2	1.67e-04	192	64	4	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.67e-04	192	64	4	43228bddca2f606ddcae9731f04c6b1502c4b85a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.67e-04	192	64	4	f5463c6bcc5c69ac562bec028f7a105c471f2fbe
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.67e-04	192	64	4	20fd69eb60b93d22d9be39de44b733db6d761dde
ToppCell	P28-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLNA GPX8 NEXN ITIH3	1.67e-04	192	64	4	87c7780cf72f4c204f2a5f6655309d47a23c08ae
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.71e-04	193	64	4	18e11d515147accef9aee26e934b358b445e18e2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.71e-04	193	64	4	7766f495f2f945802ef9a5b994cd00bb64d0dfe3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.71e-04	193	64	4	ce3e8cf30b7b4d5c7a8f3d64c21d81d2c3cab5c1
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA INAFM2 NEXN CASZ1	1.74e-04	194	64	4	bea369e9a7018d862e4d7f1c9ec2de50f3fd38ec
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A6 ADAMTS2 SNCA NEXN	1.74e-04	194	64	4	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.74e-04	194	64	4	3bff2e4eb16719ab7419b2f94c9c6e7302aa6629
ToppCell	PND07-28-samps-Mesenchymal\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	IGF2R ADAMTS2 GPX8 NEXN	1.74e-04	194	64	4	68bcc1fe8dc8d5f23a12154fc9b41362fdef0b1d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.74e-04	194	64	4	fdaf61cbe7f77ff5358d150b38adb1fe3778e961
ToppCell	P07-Mesenchymal\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLNA ADAMTS2 GPX8 NEXN	1.77e-04	195	64	4	859764b605866b6c3e6edd0698670ca9c0f20745
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	DDX60 XRN1 NEXN CASZ1	1.77e-04	195	64	4	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCSER2 NUP98 XRN1 SCAF11	1.81e-04	196	64	4	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GPX8 NEXN ADAP2	1.81e-04	196	64	4	bebb20dc210576101c317011e3afb59798f5d255
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 RALGPS1 SKAP1 CASZ1	1.81e-04	196	64	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 RALGPS1 SKAP1 CASZ1	1.81e-04	196	64	4	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	FLNA IKZF2 SKAP1 CCSER2	1.84e-04	197	64	4	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	Mild\|World / Condition, Lineage, Cell class and cell subclass	SKAP1 ZRANB2 NEXN SF3A2	1.84e-04	197	64	4	476b0d0389f9fcd4614f6bb1f494281f467f6730
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	DDX60 XRN1 ELF2 SCAF11	1.84e-04	197	64	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA ADAMTS2 GPX8 NEXN	1.84e-04	197	64	4	8c728cd3c0382c4f3e4b78647b6e1447bb40ace1
ToppCell	390C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	ATP5PF PSMB7 SRP14 ADAP2	1.88e-04	198	64	4	765aca9901d03c6f32e4e4cd8dc7006ee114940e
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	DDX60 XRN1 SCAF11 ANKRD36	1.88e-04	198	64	4	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	FLNA IKZF2 SKAP1 CCSER2	1.88e-04	198	64	4	1ca6cd8e75891fdfaddbb4a7342eec9ca4d11e5d
ToppCell	background-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS2 CPS1 ITIH3 CRP	1.88e-04	198	64	4	79f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell	E18.5-Mesenchymal\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA IGF2R ADAMTS2 NEXN	1.88e-04	198	64	4	a16aa41eab2e297e56de43c22c355df0f79315da
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	PAK1 SNCA CDC25C ADAP2	1.88e-04	198	64	4	f801157468e59b5d049f703feadc9bb0f11e85cc
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-gd_T\|ICU-SEP / Disease, condition lineage and cell class	ZNF276 IKZF2 SKAP1 STOX1	1.88e-04	198	64	4	b40899f8f5f32420fb4574069dd7afd9e7e70d91
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	FLNA DDX60 XRN1 NEXN	1.92e-04	199	64	4	c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCell	mild-CD4+_Tcm\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DDX60 SKAP1 CCSER2 ANKRD36	1.92e-04	199	64	4	06c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCell	ILEUM-inflamed-(8)_Activated_fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CA12 ADAMTS2 GPX8 NEXN	1.92e-04	199	64	4	317f412996d463ddf2e6a52ff41d5d676c77f43f
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	CA12 ADAMTS2 GPX8 NEXN	1.95e-04	200	64	4	c082bc21ec7c5323439d108ea8aea510e1113c3f
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DDX60 ZRANB2 XRN1 SCAF11	1.95e-04	200	64	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IKZF2 SKAP1 CCSER2 XRN1	1.95e-04	200	64	4	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A6 ADAMTS2 SNCA NEXN	1.95e-04	200	64	4	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	mild-unassigned\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KAT2B RALGPS1 MACROD1 XRN1	1.95e-04	200	64	4	ca0a08bf162c954f037a56aa0cbb8b5d7c6ffec0
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_Hsd17b2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CA12 SKAP1 MYBPC2	2.16e-04	81	64	3	20796e59cdeb398e7772f4356578d74a33405f71
Computational	Neighborhood of DDX5	MAZ DYRK1A SRP14 DHX9	1.15e-04	65	42	4	GCM_DDX5
Drug	SC 19220; Up 200; 10uM; PC3; HT_HG-U133A	PAK1 APC ELF4 CPS1 SNCA CDC25C DHX9	1.21e-06	194	64	7	7065_UP
Drug	lovastatin-niacin combination	LPA CRP	7.78e-06	2	64	2	ctd:C451780
Drug	Clemizole hydrochloride [1163-36-6]; Down 200; 11uM; PC3; HT_HG-U133A	CA12 APC PAK3 SNCA CDC25C CASZ1	1.71e-05	193	64	6	3672_DN
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A	TSR1 CCSER2 NUP98 RBM42 APC ELF4	1.81e-05	195	64	6	6927_DN
Drug	Cephalexin monohydrate [23325-78-2]; Down 200; 11uM; MCF7; HT_HG-U133A	RALGPS1 ELF4 SYBU CDC25C SF3A2 ADAP2	1.87e-05	196	64	6	5615_DN
Drug	N-Acetyl-L-leucine [1188-21-2]; Down 200; 23uM; HL60; HT_HG-U133A	BMPR2 DDX60 MAZ PAK1 APC SF3A2	1.87e-05	196	64	6	3085_DN
Drug	1,2-cyclohexanedione	LPA NT5C2 MCCC1 CRP	2.15e-05	58	64	4	CID000013006
Disease	HEPATOCELLULAR CARCINOMA	IGF2R APC	1.55e-04	9	62	2	114550
Disease	Hepatocellular carcinoma	IGF2R APC	1.55e-04	9	62	2	cv:C2239176
Disease	depressive disorder (is_marker_for)	SNCA CRP	1.93e-04	10	62	2	DOID:1596 (is_marker_for)
Disease	total lipids in medium VLDL	IGF2R LPA ITIH3	2.03e-04	54	62	3	EFO_0022153
Disease	Alzheimer's disease (is_marker_for)	LPA PAK1 APC STOX1 SNCA	2.08e-04	257	62	5	DOID:10652 (is_marker_for)
Disease	vascular dementia (is_marker_for)	LPA SNCA	2.36e-04	11	62	2	DOID:8725 (is_marker_for)
Disease	Kawasaki disease (is_implicated_in)	HSPA1L CRP	2.83e-04	12	62	2	DOID:13378 (is_implicated_in)
Disease	cholesterol in large VLDL measurement	IGF2R LPA ITIH3	3.52e-04	65	62	3	EFO_0021902
Disease	cholesterol in very large VLDL measurement	IGF2R LPA ITIH3	3.52e-04	65	62	3	EFO_0022230
Disease	rheumatoid arthritis (is_marker_for)	KAT2B LPA CRP	4.19e-04	69	62	3	DOID:7148 (is_marker_for)
Disease	DNA methylation	IKZF2 ADAMTS2 ABCA13 RALGPS1 LPA MACROD1 SNCA	4.43e-04	656	62	7	GO_0006306
Disease	neutrophil collagenase measurement	ABCA13 HSPA1L	5.11e-04	16	62	2	EFO_0008248
Disease	ankle brachial index	LPA SYBU	5.11e-04	16	62	2	EFO_0003912
Disease	breast cancer (is_marker_for)	KAT2B PAK1 CDC25C CRP	6.28e-04	185	62	4	DOID:1612 (is_marker_for)
Disease	Liver carcinoma	IGF2R LPA APC CDC25C ITIH3 CRP	6.80e-04	507	62	6	C2239176
Disease	Lewy Body Disease	IGF2R SNCA	9.77e-04	22	62	2	C0752347
Disease	lipoprotein A measurement	IGF2R LPA CPS1	1.71e-03	112	62	3	EFO_0006925
Disease	colorectal cancer (implicated_via_orthology)	APC SNX33	1.82e-03	30	62	2	DOID:9256 (implicated_via_orthology)
Disease	cortical surface area measurement	RALGPS1 XRN1 NT5C2 APC ELF2 SYBU STOX1 CPS1 CDC25C	1.90e-03	1345	62	9	EFO_0010736

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGKSDPYVKLKLAGR	ESYT1	671	Q9BSJ8
DTKTGKLKIGTYTGP	NT5C2	306	P49902
KTGKVGRPSKYDVRG	CASZ1	366	Q86V15
DKPVATYSGGTKRKL	ABCA13	4851	Q86UQ4
KYGEKTKRVSSRKKP	ANKRD36	1081	A6QL64
KKTKDGKREYKPPGT	DYRK1A	406	Q13627
IYKLTGTGPKNITKK	CAMSAP1	1536	Q5T5Y3
KGTFTRSPKKHGYIK	ADAMTS2	726	O95450
GLLKYFTKEQGKSPK	ADAP2	161	Q9NPF8
KVIRDKRTGKTKGYG	RBM42	411	Q9BTD8
RGTDRKHYKSTPGKK	RALGPS1	476	Q5JS13
KHYKSTPGKKVSIVG	RALGPS1	481	Q5JS13
KRGYKLPKVRKTGTT	PSMB7	31	Q99436
TYVPKLGKGDVKDKF	NEXN	21	Q0ZGT2
EKAYVPKLTGTVKGR	NEXN	91	Q0ZGT2
VGDPKKKYTRFEKIG	PAK3	276	O75914
GLVPREKSVTYGKGK	NUP98	1116	P52948
GFSKEIKIPKTKYVG	KAT2B	621	Q92831
KTLKAKYKGTPEAAV	DNAAF2	186	Q9NVR5
PIRKKSKDGKGSTIY	ELF4	196	Q99607
VKVKKRNKYSVGIGP	DDX60	721	Q8IY21
SIKKGDNKGVIYKPA	CA12	331	O43570
YGCIQGGKKDKKPTT	KRT222	151	Q8N1A0
VASALEKKTKSKGPY	MAZ	176	P56270
GKPKVLVSYKGENKA	HSPA1L	101	P34931
TTKAPKGSLKDIYKV	IKZF2	446	Q9UKS7
SGGSDSKKKKRYRPR	MED26	386	O95402
TIPDKVKKKYFSGQG	CDC25C	236	P30307
PKKKYTRFEKIGQGA	PAK1	266	Q13153
KIREYKSKRQTSGGP	ATP5PF	46	P18859
LGSKLPKYGTKSVRS	CCSER2	11	Q9H7U1
TKDVKVYGKGNPTKV	CPS1	206	P31327
VKIPTSKYTKSPGKN	HEATR5A	2016	Q86XA9
KVKVYGPGVAKTGLK	FLNA	771	P21333
APYKGSEIRGSRKSK	CCNL2	436	Q96S94
EGPPKYTKSVLKKGD	FKBP3	106	Q00688
YTKSVLKKGDKTNFP	FKBP3	111	Q00688
GSGEKIKKRVKTPYS	BMPR2	966	Q13873
GKPRVRKSLKKGYTV	CRP	131	P02741
KGYRGKKATTVTGTP	LPA	1726	P08519
IKKKPREGKGNTTYL	ELF2	196	Q15723
KTGKAKITGGYRLPA	MACROD1	206	Q9BQ69
IKSPKDGTVKKVFYR	MCCC1	686	Q96RQ3
GKKAQPVKYKTETLT	CCDC168	5681	Q8NDH2
KGRTVSLEKYKGKVS	GPX8	56	Q8TED1
KYSRKGSQKKTLEEP	SCAF11	1441	Q99590
PRTGKAYTGAAIKKL	COL6A6	301	A6NMZ7
GLTKKKEGETVEPYK	DHX9	261	Q08211
RGKPATYTGDKKAKM	INAFM2	11	P0DMQ5
SPLTKKNGAYKVETK	IGF2R	641	P11717
GKTKEGVLYVGSKTK	SNCA	31	P37840
MVSSGKKYSRKSGKP	SYCP3	1	Q8IZU3
KKYSRKSGKPSVEDQ	SYCP3	6	Q8IZU3
PDSKTRKTYFGKLGI	ITIH3	701	Q06033
DPTKQTKFKGIKSYI	SNX33	236	Q8WV41
KGTYGKVKKARESSG	NUAK2	61	Q9H093
VKKFVKIGRPGYKVT	SF3A2	106	Q15428
GKKVYKSLITGKVRS	APC	2191	P25054
SSKVVKKVPKGTSSY	TSR1	386	Q2NL82
KKYDGRTKPIPKKGT	SRP14	31	P37108
YKKESKSGLVKPGSE	SYBU	131	Q9NX95
TIGHKYPSKEGVKKR	STOX1	401	Q6ZVD7
YPERKVSGKKSESKE	ZNF276	386	Q8N554
KKNEEVPGYTKKVGS	XRN1	961	Q8IZH2
KKKYRGKAVGPASIL	ZRANB2	131	O95218
GPSKDTLVREGKTYK	ZNF80	36	P51504
EKSKQPKGTFLIKGY	SKAP1	146	Q86WV1
GGKPVTGYLVERKKK	MYBPC2	666	Q14324