Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	3.28e-07	5	65	3	GO:0030156
GeneOntologyBiologicalProcess	positive regulation of mRNA splicing, via spliceosome	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	6.91e-11	44	64	7	GO:0048026
GeneOntologyBiologicalProcess	positive regulation of mRNA processing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	1.53e-10	49	64	7	GO:0050685
GeneOntologyBiologicalProcess	positive regulation of RNA splicing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	9.53e-10	63	64	7	GO:0033120
GeneOntologyBiologicalProcess	regulation of mRNA splicing, via spliceosome	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	1.47e-07	129	64	7	GO:0048024
GeneOntologyBiologicalProcess	regulation of mRNA processing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	5.83e-07	158	64	7	GO:0050684
GeneOntologyBiologicalProcess	positive regulation of mRNA metabolic process	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E GIGYF2 THRAP3	1.34e-06	259	64	8	GO:1903313
GeneOntologyBiologicalProcess	regulation of RNA splicing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	3.55e-06	207	64	7	GO:0043484
GeneOntologyBiologicalProcess	developmental process involved in reproduction	RIMBP3 USP26 LIMK2 RSPH1 RBMY1A1 RBMY1D RBMY1B RBMY1E RIMBP3C YTHDC2 RAI14 RIMBP3B PLK4 ZNF541	2.01e-05	1235	64	14	GO:0003006
GeneOntologyBiologicalProcess	protein localization to microtubule end	ABL1 GAS2L2	2.84e-05	3	64	2	GO:1905725
GeneOntologyBiologicalProcess	protein localization to microtubule plus-end	ABL1 GAS2L2	2.84e-05	3	64	2	GO:1904825
GeneOntologyBiologicalProcess	protein localization to microtubule	ABL1 GAS2L2 CHAMP1	3.13e-05	20	64	3	GO:0035372
GeneOntologyBiologicalProcess	mRNA processing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E CCAR2 ZC3H3 THRAP3	4.83e-05	551	64	9	GO:0006397
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E GIGYF2 THRAP3	6.56e-05	443	64	8	GO:1903311
GeneOntologyBiologicalProcess	spermatogenesis	RIMBP3 USP26 LIMK2 RSPH1 RBMY1B RIMBP3C YTHDC2 RAI14 RIMBP3B ZNF541	9.13e-05	744	64	10	GO:0007283
GeneOntologyBiologicalProcess	male gamete generation	RIMBP3 USP26 LIMK2 RSPH1 RBMY1B RIMBP3C YTHDC2 RAI14 RIMBP3B ZNF541	1.11e-04	762	64	10	GO:0048232
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	1.19e-04	358	64	7	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	1.19e-04	358	64	7	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E THRAP3	1.27e-04	362	64	7	GO:0000375
GeneOntologyBiologicalProcess	RNA splicing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E CCAR2 THRAP3	1.56e-04	502	64	8	GO:0008380
GeneOntologyBiologicalProcess	neuromuscular synaptic transmission	RIMBP3 RIMBP3C RIMBP3B	1.89e-04	36	64	3	GO:0007274
GeneOntologyBiologicalProcess	T-tubule organization	BIN1 ANK2	3.36e-04	9	64	2	GO:0033292
GeneOntologyBiologicalProcess	hematopoietic progenitor cell differentiation	ABL1 RBMY1A1 RBMY1D RBMY1B RBMY1E	3.65e-04	197	64	5	GO:0002244
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	BIN1 ABL1 SSH1 GAS2L2 MYCBP2 NAV3 GRHL3 PLK4	4.08e-04	579	64	8	GO:0051493
GeneOntologyBiologicalProcess	mRNA metabolic process	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E GIGYF2 CCAR2 ZC3H3 THRAP3	4.91e-04	917	64	10	GO:0016071
GeneOntologyCellularComponent	spliceosomal complex	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	5.03e-05	215	64	6	GO:0005681
GeneOntologyCellularComponent	nuclear protein-containing complex	BIN1 BICRA RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E MLLT1 ZNF217 KDM6B ZC3H3 THRAP3 ZNF541	5.76e-05	1377	64	14	GO:0140513
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	8.49e-05	28	64	3	GO:0002177
GeneOntologyCellularComponent	male germ cell nucleus	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.41e-04	86	64	4	GO:0001673
GeneOntologyCellularComponent	microtubule end	GAS2L2 NAV3 NCKAP5L	2.14e-04	38	64	3	GO:1990752
GeneOntologyCellularComponent	axon	BIN1 ABL1 KCNB1 SSH1 MYCBP2 MINK1 HCN3 MAST1 TSC2 ALK	3.52e-04	891	64	10	GO:0030424
GeneOntologyCellularComponent	germ cell nucleus	RBMY1A1 RBMY1D RBMY1B RBMY1E	4.01e-04	113	64	4	GO:0043073
GeneOntologyCellularComponent	proximal dendrite	KCNB1 GIGYF2	9.44e-04	15	64	2	GO:1990635
MousePheno	perinatal lethality	BIN1 ABL1 WIZ ANK2 GAS2L2 TCOF1 MYCBP2 WDR11 COL27A1 MAST1 GIGYF2 GRHL3 KDM6B ALK	4.48e-05	1130	52	14	MP:0002081
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	4.51e-05	19	52	3	MP:0009377
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	6.16e-05	21	52	3	MP:0008893
MousePheno	delayed balanopreputial separation	WDR11 ALK	1.35e-04	5	52	2	MP:0008940
MousePheno	neonatal lethality	BIN1 ABL1 ANK2 GAS2L2 TCOF1 MYCBP2 COL27A1 MAST1 GIGYF2 KDM6B ALK	1.39e-04	799	52	11	MP:0002058
MousePheno	abnormal germ cell morphology	RIMBP3 USP26 LIMK2 RSPH1 WDR11 RIMBP3C YTHDC2 IRS2 RIMBP3B PLK4 ALK ZNF541	1.42e-04	946	52	12	MP:0002208
MousePheno	abnormal foam cell morphology	RIMBP3 USP26 LIMK2 RSPH1 WDR11 RIMBP3C YTHDC2 IRS2 RIMBP3B PLK4 ALK ZNF541	1.54e-04	954	52	12	MP:0009840
MousePheno	edema	RAPH1 BICRA COL27A1 NACA TMEM115 RAI14 HMGXB3 CHAMP1 PRG4	2.58e-04	581	52	9	MP:0001785
MousePheno	abnormal male germ cell morphology	RIMBP3 USP26 LIMK2 RSPH1 WDR11 RIMBP3C YTHDC2 RIMBP3B PLK4 ALK ZNF541	2.61e-04	859	52	11	MP:0006362
MousePheno	retrognathia	TCOF1 COL27A1	2.82e-04	7	52	2	MP:0004282
MousePheno	absent vertebral arch	GAS2L2 GRHL3	2.82e-04	7	52	2	MP:0004603
Domain	RBM1CTR	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	2.24e-11	8	64	5	PF08081
Domain	RBM1CTR	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	2.24e-11	8	64	5	IPR012604
Domain	SH3_9	RIMBP3 BIN1 RIMBP3C RIMBP3B	1.48e-04	78	64	4	PF14604
Domain	SH3_2	RIMBP3 BIN1 RIMBP3C RIMBP3B	2.16e-04	86	64	4	IPR011511
Domain	SH3_2	RIMBP3 BIN1 RIMBP3C RIMBP3B	2.16e-04	86	64	4	PF07653
Domain	RRM_1	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	7.30e-04	208	64	5	PF00076
Domain	SH3	RIMBP3 BIN1 ABL1 RIMBP3C RIMBP3B	8.65e-04	216	64	5	SM00326
Domain	SH3	RIMBP3 BIN1 ABL1 RIMBP3C RIMBP3B	8.65e-04	216	64	5	PS50002
Domain	RRM	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	8.83e-04	217	64	5	SM00360
Domain	SH3_domain	RIMBP3 BIN1 ABL1 RIMBP3C RIMBP3B	9.39e-04	220	64	5	IPR001452
Domain	Pkinase_Tyr	LIMK2 ABL1 PLK4 ALK	1.00e-03	129	64	4	PF07714
Domain	RRM_dom	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	1.08e-03	227	64	5	IPR000504
Domain	RRM	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	1.15e-03	230	64	5	PS50102
Domain	Ser-Thr/Tyr_kinase_cat_dom	LIMK2 ABL1 PLK4 ALK	1.29e-03	138	64	4	IPR001245
Domain	Nucleotide-bd_a/b_plait	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	1.90e-03	258	64	5	IPR012677
Domain	Kinase-like_dom	LIMK2 ABL1 RAPH1 MINK1 MAST1 PLK4 ALK	2.48e-03	542	64	7	IPR011009
Domain	PROTEIN_KINASE_TYR	ABL1 PLK4 ALK	4.50e-03	97	64	3	PS00109
Domain	Tyr_kinase_AS	ABL1 PLK4 ALK	4.50e-03	97	64	3	IPR008266
Domain	PROTEIN_KINASE_ATP	LIMK2 ABL1 MINK1 MAST1 PLK4 ALK	4.80e-03	459	64	6	PS00107
Domain	ZINC_FINGER_C2H2_2	SP2 ZNF777 WIZ ZBTB47 HIC2 ZNF217 CHAMP1 ZNF541	4.81e-03	775	64	8	PS50157
Domain	ZINC_FINGER_C2H2_1	SP2 ZNF777 WIZ ZBTB47 HIC2 ZNF217 CHAMP1 ZNF541	4.89e-03	777	64	8	PS00028
Domain	Znf_C2H2-like	SP2 ZNF777 WIZ ZBTB47 HIC2 ZNF217 CHAMP1 ZNF541	5.64e-03	796	64	8	IPR015880
Domain	Znf_C2H2	SP2 ZNF777 WIZ ZBTB47 HIC2 ZNF217 CHAMP1 ZNF541	6.03e-03	805	64	8	IPR007087
Domain	ZnF_C2H2	SP2 ZNF777 WIZ ZBTB47 HIC2 ZNF217 CHAMP1 ZNF541	6.16e-03	808	64	8	SM00355
Domain	Prot_kinase_dom	LIMK2 ABL1 MINK1 MAST1 PLK4 ALK	6.50e-03	489	64	6	IPR000719
Domain	PROTEIN_KINASE_DOM	LIMK2 ABL1 MINK1 MAST1 PLK4 ALK	6.75e-03	493	64	6	PS50011
Pubmed	A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	2.84e-16	7	67	6	8269511
Pubmed	Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene.	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	3.72e-14	12	67	6	9598316
Pubmed	RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	1.36e-13	6	67	5	15184870
Pubmed	Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene.	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	4.77e-13	7	67	5	8875892
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BIN1 SSH1 RAPH1 TCOF1 MYCBP2 SLC4A1AP MINK1 GIGYF2 CCAR2 YTHDC2 ZNF217 IRS2 CHAMP1 PRG4 THRAP3	1.68e-11	774	67	15	15302935
Pubmed	An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.28e-11	5	67	4	8817321
Pubmed	Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.28e-11	5	67	4	20016065
Pubmed	The role of human and mouse Y chromosome genes in male infertility.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.28e-11	5	67	4	11097427
Pubmed	Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.28e-11	5	67	4	19737860
Pubmed	The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.Y(TIR)sex-reversed mouse ovary.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.88e-10	6	67	4	18239052
Pubmed	Identification of target messenger RNA substrates for mouse RBMY.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.88e-10	6	67	4	18492746
Pubmed	Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.88e-10	6	67	4	12356914
Pubmed	Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.88e-10	6	67	4	9499427
Pubmed	Does Rbmy have a role in sperm development in mice?	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.88e-10	6	67	4	15051956
Pubmed	RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.	RBMY1A1 RBMY1D RBMY1B RBMY1E	4.38e-10	7	67	4	17001072
Pubmed	The roles of RNA-binding proteins in spermatogenesis and male infertility.	RBMY1A1 RBMY1D RBMY1B RBMY1E	4.38e-10	7	67	4	10377282
Pubmed	Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal.	RBMY1A1 RBMY1D RBMY1B RBMY1E	8.75e-10	8	67	4	7479793
Pubmed	MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.	USP26 RBMY1A1 RBMY1D RBMY1B RBMY1E	1.45e-09	26	67	5	35920200
Pubmed	Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.62e-09	10	67	4	10601091
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.62e-09	10	67	4	9384609
Pubmed	The role of Dby mRNA in early development of male mouse zygotes.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.15e-09	12	67	4	20543856
Pubmed	GASZ promotes germ cell derivation from embryonic stem cells.	RBMY1A1 RBMY1D RBMY1B RBMY1E	8.87e-09	13	67	4	23816659
Pubmed	RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.	RBMY1A1 RBMY1C RBMY1F RBMY1B	8.87e-09	13	67	4	10749975
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B ZNF541	1.24e-08	14	67	4	17662146
Pubmed	Absence of mDazl produces a final block on germ cell development at meiosis.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.24e-08	14	67	4	14611631
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.69e-08	15	67	4	14762062
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	2.73e-08	4	67	3	19091768
Pubmed	Loss of maternal Trim28 causes male-predominant early embryonic lethality.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.94e-08	17	67	4	28115466
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	BIN1 WIZ ANK2 KCNB1 SSH1 TCOF1 MYCBP2 MINK1 HCN3 GIGYF2 CCAR2 TSC2 THRAP3	3.30e-08	963	67	13	28671696
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.77e-08	18	67	4	12023983
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	6.81e-08	5	67	3	17855024
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP31 LIMK2 ABL1 RAPH1 MYCBP2 MINK1 GIGYF2 RAI14 TSC2 IRS2 NCKAP5L PLK4	8.45e-08	861	67	12	36931259
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	USP26 RBMY1A1 RBMY1D RBMY1B RBMY1E	1.05e-07	59	67	5	11279525
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CEP104 BIN1 ANK2 KCNB1 MYCBP2 MINK1 HCN3 GIGYF2	3.54e-07	347	67	8	17114649
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	USP31 WIZ SSH1 RAPH1 MYCBP2 WDR11 SLC4A1AP MINK1 CCAR2 RAI14 NCKAP5L PLK4	6.93e-07	1049	67	12	27880917
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	WIZ RAPH1 MYCBP2 GIGYF2 RAI14 ZNF217 IRS2 CHAMP1	1.43e-06	418	67	8	34709266
Pubmed	Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.	RBMY1A1 RBMY1B	3.66e-06	2	67	2	32473614
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.98e-06	55	67	4	19468303
Pubmed	Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.	MYCBP2 TSC2 ALK	4.56e-06	17	67	3	19398581
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	BIN1 WIZ ANK2 RSPH1 TCOF1 MYCBP2 NAV3 ZBTB47 MAST1 RAI14 TSC2 KDM6B	5.63e-06	1285	67	12	35914814
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	WIZ SSH1 WDR11 NACA YTHDC2 THRAP3	5.87e-06	232	67	6	25515538
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LIMK2 WIZ TCOF1 BICRA MLLT1 HIC2 YTHDC2 IRS2 NCKAP5L CHAMP1 ZC3H3	8.77e-06	1116	67	11	31753913
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	WIZ RAPH1 TCOF1 MYCBP2 GIGYF2 RAI14 CHAMP1 THRAP3	1.06e-05	549	67	8	38280479
Pubmed	The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation.	BIN1 ABL1	1.10e-05	3	67	2	9356459
Pubmed	Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.	KCNB1 RAI14	1.10e-05	3	67	2	19454037
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	WIZ ANK2 RAPH1 TCOF1 NACA GIGYF2 YTHDC2 RAI14 IRS2 CHAMP1	1.15e-05	934	67	10	33916271
Pubmed	Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.	MYCBP2 TSC2	2.19e-05	4	67	2	14559897
Pubmed	Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.	TSC2 PLK4	2.19e-05	4	67	2	22840514
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	MYCBP2 GIGYF2 RAI14 TSC2 IRS2	3.39e-05	190	67	5	15161933
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.51e-05	95	67	4	24029230
Pubmed	c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.	ABL1 RAPH1	3.64e-05	5	67	2	20417104
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	LRRC3 BIN1 ABL1 ANK2 BICRA PRG4	4.21e-05	329	67	6	17474147
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABL1 WIZ SSH1 MYCBP2 BICRA MLLT1 HMGXB3 TSC2 IRS2 KDM6B	4.83e-05	1105	67	10	35748872
Pubmed	RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.	BIN1 ABL1	5.46e-05	6	67	2	22976291
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	RAPH1 WDR11 NACA GIGYF2 YTHDC2	6.23e-05	216	67	5	31519766
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP104 NACA HIC2 RAI14 HMGXB3 KDM6B CHAMP1	7.16e-05	529	67	7	14621295
Pubmed	The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.	MYCBP2 TSC2	7.63e-05	7	67	2	22798074
Pubmed	Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer.	TSC2 IRS2	7.63e-05	7	67	2	20354165
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	MYCBP2 GIGYF2 CCAR2	8.55e-05	44	67	3	26471122
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZNF777 WIZ SLC4A1AP BICRA MLLT1 GIGYF2 CHAMP1 ALK THRAP3	8.70e-05	954	67	9	36373674
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	WIZ SLC4A1AP NACA GIGYF2 CCAR2 YTHDC2 THRAP3	9.22e-05	551	67	7	34728620
Pubmed	The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	1.04e-04	241	67	5	12815422
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MYCBP2 WDR11 TSPAN10 BICRA MINK1 MAST1 RAI14 ASPSCR1 ZNF767P THRAP3 PDZD2	1.21e-04	1489	67	11	28611215
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	WIZ TCOF1 WDR11 MINK1 TMEM115 CCAR2 RAI14 THRAP3	1.22e-04	777	67	8	35844135
Pubmed	Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.	LIMK2 SSH1	1.30e-04	9	67	2	15660133
Pubmed	Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations.	LIMK2 SSH1	1.30e-04	9	67	2	27588418
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP31 NAV3 MAST1 GIGYF2 CCAR2 PDZD2	1.35e-04	407	67	6	12693553
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	MYCBP2 RAI14 TSC2 IRS2 THRAP3	1.36e-04	255	67	5	15324660
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	RAPH1 TCOF1 NACA GIGYF2 RAI14	1.38e-04	256	67	5	33397691
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	CEP104 USP31 SSH1 TCOF1 GIGYF2 ALK	1.60e-04	420	67	6	28065597
Pubmed	T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.	RBMY1A1 RBMY1C	1.63e-04	10	67	2	10332027
Pubmed	Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.	ABL1 ALK	1.99e-04	11	67	2	16135792
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	SP2 WIZ TSC2 CHAMP1 ZC3H3	2.13e-04	281	67	5	24163370
Pubmed	Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex.	WIZ ZNF217	2.38e-04	12	67	2	17967884
Pubmed	Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.	USP26 CCAR2	2.81e-04	13	67	2	35913115
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	RAPH1 SLC4A1AP NACA MLLT1 ASPSCR1 CHAMP1	3.00e-04	472	67	6	38943005
Pubmed	The DNA sequence and analysis of human chromosome 13.	MYCBP2 TEX29 IRS2 CHAMP1	3.32e-04	170	67	4	15057823
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RAPH1 TCOF1 SLC4A1AP NACA GIGYF2 CCAR2 TSC2 IRS2 CHAMP1 THRAP3	3.61e-04	1415	67	10	28515276
Pubmed	Human transcription factor protein interaction networks.	SP2 WIZ BICRA NACA MLLT1 GIGYF2 CCAR2 HIC2 RAI14 ZNF217	3.90e-04	1429	67	10	35140242
Pubmed	The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.	NACA GIGYF2 RAI14	4.02e-04	74	67	3	35102251
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ANK2 TCOF1 MINK1 GIGYF2 YTHDC2 RAI14 IRS2	4.24e-04	708	67	7	39231216
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	WIZ RAPH1 TCOF1 SLC4A1AP RAI14 THRAP3	4.34e-04	506	67	6	30890647
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	GIGYF2 CCAR2 ZNF217 NCKAP5L	4.48e-04	184	67	4	32908313
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	WIZ TCOF1 TSC2 CHAMP1 THRAP3	5.17e-04	341	67	5	32971831
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	ANK2 KCNB1	5.48e-04	18	67	2	37321992
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	GIGYF2 KDM6B	5.48e-04	18	67	2	25363768
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	WIZ WDR11 SLC4A1AP MINK1 NACA MLLT1 YTHDC2 RAI14 ZNF217 ZNF767P	5.61e-04	1497	67	10	31527615
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	WIZ HIC2	6.12e-04	19	67	2	30385546
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	WIZ CHAMP1 THRAP3	6.24e-04	86	67	3	37253089
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	TCOF1 MYCBP2 GIGYF2 THRAP3	6.36e-04	202	67	4	24639526
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	ABL1 IRS2 THRAP3	6.45e-04	87	67	3	29991678
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	TCOF1 NACA GIGYF2 RAI14	6.48e-04	203	67	4	22083510
Pubmed	Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.	ABL1 KCNB1 MINK1 ASPSCR1	6.48e-04	203	67	4	19953087
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	RAPH1 MYCBP2 YTHDC2 IRS2 THRAP3	6.68e-04	361	67	5	26167880
Pubmed	Myosin-X recruits lamellipodin to filopodia tips.	RAPH1 MYCBP2 THRAP3	6.89e-04	89	67	3	36861887
Pubmed	A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.	MYCBP2 THRAP3	7.50e-04	21	67	2	24923560
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RAPH1 WDR11 TMEM115 GIGYF2 YTHDC2 RAI14	7.94e-04	568	67	6	37774976
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	WIZ NACA GIGYF2 THRAP3	8.03e-04	215	67	4	35973513
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	WIZ CCAR2 HIC2 YTHDC2 CHAMP1 THRAP3	9.08e-04	583	67	6	29844126
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	NACA GIGYF2 CCAR2 YTHDC2	9.19e-04	223	67	4	20020773
Interaction	PNMA2 interactions	WIZ RSPH1 MAST1 GIGYF2 HIC2 RIMBP3C KDM6B ZC3H3	1.59e-06	251	66	8	int:PNMA2
Interaction	YWHAZ interactions	USP31 BIN1 ABL1 SSH1 RAPH1 MYCBP2 MINK1 MAST1 GIGYF2 CCAR2 RAI14 TSC2 IRS2 NCKAP5L PLK4	1.80e-05	1319	66	15	int:YWHAZ
Interaction	YWHAB interactions	USP31 BIN1 ABL1 SSH1 MYCBP2 MINK1 MAST1 GIGYF2 RAI14 TSC2 IRS2 NCKAP5L PLK4	2.09e-05	1014	66	13	int:YWHAB
Interaction	FBXW11 interactions	WIZ SSH1 WDR11 NACA YTHDC2 IRS2 NCKAP5L PLK4 THRAP3	2.26e-05	473	66	9	int:FBXW11
Interaction	YWHAE interactions	USP31 ABL1 SSH1 MYCBP2 RBMY1A1 MINK1 MAST1 GIGYF2 CCAR2 RAI14 TSC2 IRS2 NCKAP5L PLK4	4.52e-05	1256	66	14	int:YWHAE
Interaction	YWHAH interactions	USP31 ABL1 SSH1 MYCBP2 MINK1 MAST1 GIGYF2 CCAR2 RAI14 TSC2 IRS2 NCKAP5L PLK4	4.96e-05	1102	66	13	int:YWHAH
Interaction	RBMY1E interactions	RBMY1F RBMY1E	6.31e-05	4	66	2	int:RBMY1E
Cytoband	Yq11.223	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	2.68e-07	93	67	5	Yq11.223
Cytoband	22q11.21	RIMBP3 HIC2 RIMBP3C RIMBP3B	2.21e-05	111	67	4	22q11.21
Cytoband	13q34	TEX29 IRS2 CHAMP1	6.99e-05	54	67	3	13q34
Cytoband	Ensembl 112 genes in cytogenetic band chrYq11	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	9.46e-05	311	67	5	chrYq11
Cytoband	Ensembl 112 genes in cytogenetic band chr13q34	TEX29 IRS2 CHAMP1	2.98e-04	88	67	3	chr13q34
Cytoband	20q13.2	KCNB1 ZNF217	7.19e-04	27	67	2	20q13.2
Cytoband	5q32	TCOF1 HMGXB3	2.86e-03	54	67	2	5q32
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	RIMBP3 HIC2 RIMBP3C RIMBP3B	3.33e-03	419	67	4	chr22q11
Cytoband	7q36.1	ZNF777 ZNF767P	5.30e-03	74	67	2	7q36.1
Cytoband	Ensembl 112 genes in cytogenetic band chr5q32	TCOF1 HMGXB3	6.16e-03	80	67	2	chr5q32
GeneFamily	RNA binding motif containing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	1.21e-05	213	44	6	725
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP2 ZNF777 WIZ ZBTB47 HIC2 ZNF217 ZNF767P CHAMP1 ZNF541	4.75e-05	718	44	9	28
GeneFamily	PDZ domain containing	LIMK2 MAST1 PDZD2	6.00e-03	152	44	3	1220
GeneFamily	Ubiquitin specific peptidases	USP26 USP31	8.20e-03	56	44	2	366
Coexpression	CHEN_ETV5_TARGETS_TESTIS	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.42e-06	33	66	4	MM701
Coexpression	ZHENG_IL22_SIGNALING_DN	RBMY1A1 RBMY1D RBMY1B RBMY1E	5.05e-06	45	66	4	MM763
Coexpression	GRESHOCK_CANCER_COPY_NUMBER_UP	ABL1 NACA MLLT1 TSC2 ASPSCR1 ALK THRAP3	1.69e-05	323	66	7	M9150
Drug	hydantoin-5-propionic acid	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.28e-07	21	64	4	CID000000782
Drug	AZFd	RBMY1A1 RBMY1D RBMY1B RBMY1E	4.83e-07	23	64	4	CID000196489
Drug	Vistar	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.13e-06	36	64	4	CID000040896
Drug	2-chlorodideoxyadenosine	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.45e-06	43	64	4	CID000072194
Drug	PKI166	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.01e-05	48	64	4	CID006918403
Drug	HgCl	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.09e-05	49	64	4	CID000024182
Drug	azafagomine	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.01e-05	57	64	4	CID011957435
Drug	thioglycolate	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.81e-05	67	64	4	CID000001133
Drug	SU6668	RBMY1A1 RBMY1D RBMY1B RBMY1E	4.53e-05	70	64	4	CID000206042
Disease	brain aneurysm	LRRC3 MINK1 ZNF767P PDZD2	6.89e-05	113	57	4	EFO_0003870
Disease	linguistic error measurement, specific language impairment	CRYBB1 GPR157	1.63e-04	10	57	2	EFO_0007798, EFO_1001510
Disease	reticulocyte measurement	WIZ MAST1 RAI14 ZNF217 IRS2 KDM6B ZNF767P THRAP3 PDZD2	1.75e-04	1053	57	9	EFO_0010700
Disease	brain infarction	TEX29 ALK	5.50e-04	18	57	2	EFO_0004277
Disease	Ovarian Serous Adenocarcinoma	MAST1 ALK	9.04e-04	23	57	2	C1335177
Disease	Parkinson's disease (biomarker_via_orthology)	ABL1 HCN3	1.54e-03	30	57	2	DOID:14330 (biomarker_via_orthology)
Disease	colorectal adenoma	SSH1 ZNF217	1.86e-03	33	57	2	EFO_0005406

Protein segments in the cluster

Peptide	Gene	Start	Entry
KAGGKPASSPGTPLS	USP26	671	Q9BXU7
DLLPPPGKSTKPGAA	CCAR2	781	Q8N163
SAKLPKSLSSPGGPS	ASPSCR1	266	Q9BZE9
EGPPAKHPSLKPTTG	ANKRD20A8P	326	Q5CZ79
TKGKGAPPAGTSPSP	CRYBB1	21	P53674
SRSGGPPPKKSAPSA	RBMY1A1	156	P0DJD3
SRSGGPPPKKSAPSA	RBMY1B	156	A6NDE4
SRSGGPPPKKSAPSA	RBMY1C	156	P0DJD4
SRSGGPPPKKSAPSA	RBMY1D	156	P0C7P1
SRSGGPPPKKSAPSA	RBMY1E	156	A6NEQ0
SRSGGPPPKKSAPSA	RBMY1F	156	Q15415
PSLGKPGETSPPDSK	RAI14	396	Q9P0K7
SKTSSPGGKKPPPTP	RAPH1	961	Q70E73
PSPLGASPKKPGCSS	RIMBP3B	6	A6NNM3
PSPLGASPKKPGCSS	RIMBP3C	6	A6NJZ7
PSGKTDKRPPVSPSG	ANK2	1906	Q01484
APSLGKPNKSPHSSP	NCKAP5L	801	Q9HCH0
SKSPGPSSPKEPLLF	LIMK2	291	P53671
KSLPSAPASKDPIGP	LRRC3	241	Q9BY71
PDLGGASKAKPPTAP	KDM6B	1036	O15054
SSPLPAPKKPTGADL	HMGXB3	476	Q12766
SPGLGTPLKSPSLAK	PDZD2	841	O15018
IPSSSGIPKPGSKVP	NAV3	521	Q8IVL0
TAASGPIPKSGPEPK	HCN3	31	Q9P1Z3
LSGPRSKPASPKLSP	MAST1	1491	Q9Y2H9
LDFSSPKSPKPGAPS	IRS2	981	Q9Y4H2
SGPLGSKAGSKIPTP	CEP104	896	O60308
TPGKAAPLPAGPSKL	GRHL3	141	Q8TE85
DSSPPKSLPGSTSPK	KCNB1	771	Q14721
GGSITSPPLSPALPK	GIGYF2	21	Q6Y7W6
TRKPGPSGPSESPKA	CHAMP1	496	Q96JM3
SLSHKPGSFLKPPAP	GAS2L2	276	Q8NHY3
SPAGTPKAPAPSKPG	GPR157	306	Q5UAW9
PPPAASAGKAGGKPS	ABL1	901	P00519
PAVPTPGSAPTGSKK	COL27A1	521	Q8IZC6
TKLESTSPKGGPPPP	MLLT1	261	Q03111
AKGNKSPSPPDGSPA	BIN1	291	O00499
APLKGPGPSSSPSLP	BICRA	766	Q9NZM4
PLAKSKPGSTGPEPP	MINK1	536	Q8N4C8
GLDLSKKSPPLPPAT	HIC2	246	Q96JB3
SPRKGAAPTPPGKTG	TCOF1	906	Q13428
PSPLGASPKKPGCSS	RIMBP3	6	Q9UFD9
ESPGPGSRLSSPKPK	MYCBP2	2811	O75592
GLGHPPSSPLLKKTP	WIZ	976	O95785
TPTLPKKPTSTDGPG	RSPH1	221	Q8WYR4
KPGSTSSPKALSPPP	PLK4	806	O00444
TSPPSSKKAPPPSGA	PRG4	111	Q92954
APASLEGGSLKSPPP	SSH1	886	Q8WYL5
PPPLPTTSSGKAAKK	ALK	1441	Q9UM73
STPPPDASSPGGKKI	ARNTL	526	O00327
GSKGESPKTTPSPSP	ZNF767P	101	Q75MW2
PRKPATSSKPGSAPS	ZC3H3	361	Q8IXZ2
PSKKSPVGKSPPSTG	THRAP3	311	Q9Y2W1
KPAPLPLSPGKNSFG	SP2	71	Q02086
KAPTPPGKGAAPESS	TMEM115	326	Q12893
GKRPKPPPGVASASA	ZBTB47	401	Q9UFB7
ALSGTPKKGPAPSLS	TSPAN10	56	Q9H1Z9
PKKGPAPSLSPGSSC	TSPAN10	61	Q9H1Z9
ASPSPPSSGKGSKSP	YTHDC2	1266	Q9H6S0
PSSGKGSKSPSPRPN	YTHDC2	1271	Q9H6S0
SLPSAKGKQSPPGPG	ZNF217	786	O75362
SSKLGLKPASPGPPS	TEX29	111	Q8N6K0
KKASGPATRSPFPPG	USP31	1131	Q70CQ4
SDFSPSKPPSGPGKK	WDR11	186	Q9BZH6
ALKPRPKSPSSGSGG	ZNF777	616	Q9ULD5
EKKTSGPLSPPTGPP	TSC2	656	P49815
SPPGTKKPLDPTAAA	ZNF541	896	Q9H0D2
PVPGPKSHPSASSGK	ART3	351	Q13508
PGSLSLKGPVSPPAA	NACA	261	E9PAV3
SPSLPPAGTPPGTKK	NACA	736	E9PAV3
PSPKGSPAATPLPKG	NACA	1041	E9PAV3
SPKGGPATPSLKGAP	NACA	1066	E9PAV3
PSPKGGLATPPHKGA	NACA	1111	E9PAV3
SPKGGLATPSPKGAP	NACA	1181	E9PAV3
TPPSPKGGLATPSPK	NACA	1201	E9PAV3
PSPKGGLATPSPKGA	NACA	1226	E9PAV3
PPAATPPSLKGGLAT	NACA	1266	E9PAV3
PPSLKGGLATPPHKG	NACA	1271	E9PAV3
APKGGPATPSSKGDP	NACA	1451	E9PAV3
KGPATPAPKGTPTSP	NACA	1626	E9PAV3
GKDASHSPKGPLAPP	NACA	1751	E9PAV3
HSPKGPLAPPESKAS	NACA	1756	E9PAV3
KTPGPGKLPPTLSSK	SLC4A1AP	751	Q9BWU0