Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpre-mRNA 3'-splice site binding

ZRSR2P1 ZRSR2

9.90e-057442GO:0030628
GeneOntologyMolecularFunctionadenylate kinase activity

AK9 AK7

1.69e-049442GO:0004017
GeneOntologyBiologicalProcesssmooth endoplasmic reticulum calcium ion homeostasis

PSEN1 APP

1.33e-053442GO:0051563
GeneOntologyBiologicalProcessspermatid development

AXDND1 ALMS1 CCDC136 TTLL5 ZFY PDILT

1.87e-05262446GO:0007286
GeneOntologyBiologicalProcessspermatid differentiation

AXDND1 ALMS1 CCDC136 TTLL5 ZFY PDILT

2.31e-05272446GO:0048515
GeneOntologyBiologicalProcessastrocyte activation involved in immune response

PSEN1 APP

2.66e-054442GO:0002265
GeneOntologyBiologicalProcesspositive regulation of glycolytic process

MYC PSEN1 APP

3.18e-0529443GO:0045821
GeneOntologyBiologicalProcessendoplasmic reticulum calcium ion homeostasis

PSEN1 APP KCTD17

3.18e-0529443GO:0032469
GeneOntologyBiologicalProcesspositive regulation of nucleotide catabolic process

MYC PSEN1 APP

3.18e-0529443GO:0030813
GeneOntologyBiologicalProcesspositive regulation of purine nucleotide catabolic process

MYC PSEN1 APP

3.18e-0529443GO:0033123
GeneOntologyBiologicalProcesspositive regulation of amyloid fibril formation

PSEN1 APP

4.43e-055442GO:1905908
GeneOntologyBiologicalProcesschromatin organization

MYC ZNF462 BRPF3 UTP3 POLE3 APP SRCAP ARID1A ZFY

9.52e-05896449GO:0006325
GeneOntologyBiologicalProcesspositive regulation of ATP metabolic process

MYC PSEN1 APP

1.46e-0448443GO:1903580
GeneOntologyBiologicalProcessprotein-DNA complex organization

MYC ZNF462 BRPF3 UTP3 POLE3 APP SRCAP ARID1A ZFY

2.17e-04999449GO:0071824
GeneOntologyBiologicalProcesspositive regulation of nucleotide metabolic process

MYC PSEN1 APP

2.20e-0455443GO:0045981
GeneOntologyBiologicalProcesspositive regulation of purine nucleotide metabolic process

MYC PSEN1 APP

2.20e-0455443GO:1900544
GeneOntologyBiologicalProcessestrogen receptor signaling pathway

UBA5 PPARGC1B ARID1A

2.45e-0457443GO:0030520
GeneOntologyBiologicalProcessregulation of nucleotide catabolic process

MYC PSEN1 APP

3.29e-0463443GO:0030811
GeneOntologyBiologicalProcessregulation of purine nucleotide catabolic process

MYC PSEN1 APP

3.29e-0463443GO:0033121
GeneOntologyBiologicalProcessregulation of glycolytic process

MYC PSEN1 APP

3.29e-0463443GO:0006110
GeneOntologyBiologicalProcesscilium assembly

ALMS1 LRRC43 HAP1 AK7 TTLL5 KCTD17

3.40e-04444446GO:0060271
GeneOntologyBiologicalProcessneuron projection maintenance

PSEN1 APP

3.42e-0413442GO:1990535
GeneOntologyBiologicalProcessnucleoside monophosphate phosphorylation

AK9 AK7

3.42e-0413442GO:0046940
GeneOntologyBiologicalProcesscilium organization

ALMS1 LRRC43 HAP1 AK7 TTLL5 KCTD17

4.91e-04476446GO:0044782
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

ALMS1 LRRC43 HAP1 AK7 STK26 TTLL5 KCTD17

4.98e-04670447GO:0120031
GeneOntologyBiologicalProcessamyloid precursor protein catabolic process

PSEN1 APP HAP1

5.08e-0473443GO:0042987
GeneOntologyBiologicalProcessgerm cell development

AXDND1 ALMS1 CCDC136 TTLL5 ZFY PDILT

5.25e-04482446GO:0007281
GeneOntologyBiologicalProcessorganelle assembly

PSEN1 ALMS1 LRRC43 HAP1 AK7 CCDC136 TTLL5 KCTD17 PWP2

5.65e-041138449GO:0070925
GeneOntologyBiologicalProcesscell projection assembly

ALMS1 LRRC43 HAP1 AK7 STK26 TTLL5 KCTD17

5.68e-04685447GO:0030031
GeneOntologyBiologicalProcessepigenetic regulation of gene expression

MYC POLE3 APP ARID1A ZFY

6.62e-04330445GO:0040029
GeneOntologyBiologicalProcessregulation of carbohydrate catabolic process

MYC PSEN1 APP

7.13e-0482443GO:0043470
GeneOntologyBiologicalProcessregulation of amyloid fibril formation

PSEN1 APP

7.43e-0419442GO:1905906
GeneOntologyBiologicalProcesscellular process involved in reproduction in multicellular organism

AXDND1 ALMS1 CCDC136 TTLL5 ZFY PDILT

8.37e-04527446GO:0022412
GeneOntologyBiologicalProcesschromatin remodeling

MYC BRPF3 POLE3 APP SRCAP ARID1A ZFY

9.03e-04741447GO:0006338
GeneOntologyBiologicalProcessspermatogenesis

AXDND1 ALMS1 AK7 CCDC136 TTLL5 ZFY PDILT

9.24e-04744447GO:0007283
GeneOntologyBiologicalProcesshemopoiesis

MYC UBA5 PPARGC1B BRPF3 PSEN1 APP ARID1A MS4A1 ZC3H8

9.47e-041223449GO:0030097
GeneOntologyBiologicalProcessregulation of ATP metabolic process

MYC PSEN1 APP

9.65e-0491443GO:1903578
GeneOntologyBiologicalProcessregulation of epidermal growth factor-activated receptor activity

PSEN1 APP

1.00e-0322442GO:0007176
GeneOntologyBiologicalProcessmale gamete generation

AXDND1 ALMS1 AK7 CCDC136 TTLL5 ZFY PDILT

1.06e-03762447GO:0048232
GeneOntologyCellularComponentU2AF complex

ZRSR2P1 ZRSR2

9.03e-057442GO:0089701
GeneOntologyCellularComponentnuclear protein-containing complex

MYC ZRSR2P1 PPARGC1B TIMELESS POLE3 SRCAP ARID1A ZRSR2 ZC3H8 EPB41L2 PWP2

9.89e-0513774411GO:0140513
GeneOntologyCellularComponentciliary rootlet

PSEN1 APP

5.10e-0416442GO:0035253
GeneOntologyCellularComponentFAR/SIN/STRIPAK complex

STK24 STK26

5.77e-0417442GO:0090443
GeneOntologyCellularComponentchromatin

MYC ZFHX2 BRPF3 TIMELESS POLE3 SRCAP ARID1A ZHX1 ZC3H8 ZFY

8.25e-0414804410GO:0000785
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

POLE3 SRCAP ARID1A

1.08e-0396443GO:0070603
DomainU2AF_small

ZRSR2P1 ZRSR2

5.15e-055432IPR009145
DomainZnF_C3H1

ZRSR2P1 ZRSR2 ZC3H8

1.83e-0448433SM00356
Domainzf-CCCH

ZRSR2P1 ZRSR2 ZC3H8

1.95e-0449433PF00642
DomainAdenylat/UMP-CMP_kin

AK9 AK7

2.30e-0410432IPR000850
DomainZnf_CCCH

ZRSR2P1 ZRSR2 ZC3H8

3.21e-0458433IPR000571
DomainTTL

TTLL12 TTLL5

3.97e-0413432PS51221
DomainTTL/TTLL_fam

TTLL12 TTLL5

3.97e-0413432IPR004344
DomainTTL

TTLL12 TTLL5

3.97e-0413432PF03133
Domain-

ZRSR2 ZC3H8

3.82e-03404324.10.1000.10
DomainER_TARGET

P3H3 PDILT

5.24e-0347432PS00014
DomainZF_C3H1

ZRSR2 ZC3H8

7.89e-0358432PS50103
DomainZINC_FINGER_C2H2_2

ZBTB9 ZNF462 ZFHX2 ZHX1 ZFY ZNF316

8.24e-03775436PS50157
DomainZINC_FINGER_C2H2_1

ZBTB9 ZNF462 ZFHX2 ZHX1 ZFY ZNF316

8.34e-03777436PS00028
DomainZnf_C2H2-like

ZBTB9 ZNF462 ZFHX2 ZHX1 ZFY ZNF316

9.33e-03796436IPR015880
DomainZnf_C2H2

ZBTB9 ZNF462 ZFHX2 ZHX1 ZFY ZNF316

9.83e-03805436IPR007087
DomainZnF_C2H2

ZBTB9 ZNF462 ZFHX2 ZHX1 ZFY ZNF316

1.00e-02808436SM00355
DomainRRM_1

ZRSR2P1 PPARGC1B ZRSR2

1.21e-02208433PF00076
Domain4_helix_cytokine-like_core

TTLL12 ZFY

1.26e-0274432IPR009079
DomainRRM

ZRSR2P1 PPARGC1B ZRSR2

1.36e-02217433SM00360
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

MYC ZBTB9 BRPF3 APP SRCAP ALMS1 ARID1A ANKHD1 P3H3 TPRN ZNF316

1.03e-071116441131753913
Pubmed

Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes.

PSEN1 APP

1.56e-06244237608393
Pubmed

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice.

PSEN1 APP

1.56e-06244224998414
Pubmed

Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.

PSEN1 APP

1.56e-06244215198121
Pubmed

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice.

PSEN1 APP

1.56e-06244220359773
Pubmed

EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways.

PSEN1 APP

1.56e-06244234638752
Pubmed

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change.

PSEN1 APP

1.56e-06244223563578
Pubmed

The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations.

PSEN1 APP

1.56e-06244238824433
Pubmed

Voxel-based diffusion tensor imaging of an APP/PS1 mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244223877934
Pubmed

The hypothalamus as the primary brain region of metabolic abnormalities in APP/PS1 transgenic mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244229107091
Pubmed

Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.

PSEN1 APP

1.56e-06244220806406
Pubmed

Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer's disease variants: AβPParc and PSEN1DE9.

PSEN1 APP

1.56e-06244232581318
Pubmed

Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice.

PSEN1 APP

1.56e-06244221109328
Pubmed

Proteome characterization of splenocytes from an Aβpp/ps-1 Alzheimer's disease model.

PSEN1 APP

1.56e-06244224293237
Pubmed

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein.

PSEN1 APP

1.56e-06244212431992
Pubmed

Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes.

PSEN1 APP

1.56e-06244216325786
Pubmed

Identification of PSEN1 and APP gene mutations in Korean patients with early-onset Alzheimer's disease.

PSEN1 APP

1.56e-06244218437002
Pubmed

EEG, activity, and sleep architecture in a transgenic AβPPswe/PSEN1A246E Alzheimer's disease mouse.

PSEN1 APP

1.56e-06244220858963
Pubmed

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1δE9-deleted transgenic mice model of ß-amyloidosis.

PSEN1 APP

1.56e-06244218790549
Pubmed

Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.

PSEN1 APP

1.56e-06244214993906
Pubmed

Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm.

PSEN1 APP

1.56e-06244229298895
Pubmed

Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum.

PSEN1 APP

1.56e-06244210441572
Pubmed

siRNA against presenilin 1 (PS1) down regulates amyloid β42 production in IMR-32 cells.

PSEN1 APP

1.56e-06244222214483
Pubmed

Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.

PSEN1 APP

1.56e-06244219272356
Pubmed

Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia.

PSEN1 APP

1.56e-06244232003387
Pubmed

Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations.

PSEN1 APP

1.56e-06244223380992
Pubmed

Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models.

PSEN1 APP

1.56e-06244224305500
Pubmed

Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice.

PSEN1 APP

1.56e-06244234450329
Pubmed

ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.

ZRSR2P1 ZRSR2

1.56e-06244233691379
Pubmed

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

PSEN1 APP

1.56e-06244220921220
Pubmed

Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice.

PSEN1 APP

1.56e-06244226830653
Pubmed

Novel behavioural characteristics of the APP(Swe)/PS1ΔE9 transgenic mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244223419740
Pubmed

Computational analysis of Alzheimer-causing mutations in amyloid precursor protein and presenilin 1.

PSEN1 APP

1.56e-06244231697913
Pubmed

A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244221762767
Pubmed

Interneurons and beta-amyloid in the olfactory bulb, anterior olfactory nucleus and olfactory tubercle in APPxPS1 transgenic mice model of Alzheimer's disease.

PSEN1 APP

1.56e-06244223904197
Pubmed

The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.

PSEN1 APP

1.56e-06244222459153
Pubmed

Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice.

PSEN1 APP

1.56e-06244224684630
Pubmed

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.

PSEN1 APP

1.56e-06244224623762
Pubmed

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.

PSEN1 APP

1.56e-06244217630980
Pubmed

Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice.

PSEN1 APP

1.56e-06244217912741
Pubmed

The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244222418058
Pubmed

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.

PSEN1 APP

1.56e-06244219046405
Pubmed

Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease.

PSEN1 APP

1.56e-06244217229472
Pubmed

Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice.

PSEN1 APP

1.56e-06244238515329
Pubmed

Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.

PSEN1 APP

1.56e-06244218760694
Pubmed

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

PSEN1 APP

1.56e-06244212493731
Pubmed

Generation of a novel murine model of Aβ deposition based on the expression of human wild-type amyloid precursor protein gene.

PSEN1 APP

1.56e-06244222874668
Pubmed

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.

PSEN1 APP

1.56e-0624429427614
Pubmed

Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum.

PSEN1 APP

1.56e-06244219772895
Pubmed

Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244222265986
Pubmed

Presenilin 1 and APP Gene Mutations in Early-Onset AD Families from a Southeast Region of China.

PSEN1 APP

1.56e-06244232579498
Pubmed

A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.

PSEN1 APP

1.56e-06244234329683
Pubmed

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions.

PSEN1 APP

1.56e-06244223064434
Pubmed

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.

PSEN1 APP

1.56e-06244210593990
Pubmed

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

PSEN1 APP

1.56e-06244210801777
Pubmed

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

PSEN1 APP

1.56e-06244229211722
Pubmed

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice.

PSEN1 APP

1.56e-06244226317549
Pubmed

Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells.

PSEN1 APP

1.56e-06244217405936
Pubmed

Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins.

PSEN1 APP

1.56e-06244215764367
Pubmed

Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease.

PSEN1 APP

1.56e-06244217070803
Pubmed

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

PSEN1 APP

1.56e-06244218430735
Pubmed

Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.

PSEN1 APP

1.56e-06244222144675
Pubmed

Early induction of c-Myc is associated with neuronal cell death.

MYC APP

1.56e-06244222005580
Pubmed

Age- and Brain Region-Specific Changes of Glucose Metabolic Disorder, Learning, and Memory Dysfunction in Early Alzheimer's Disease Assessed in APP/PS1 Transgenic Mice Using 18F-FDG-PET.

PSEN1 APP

1.56e-06244227763550
Pubmed

Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors.

PSEN1 APP

1.56e-06244216303255
Pubmed

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

PSEN1 APP

1.56e-06244211896164
Pubmed

Regional metabolic alteration of Alzheimer's disease in mouse brain expressing mutant human APP-PS1 by 1H HR-MAS.

PSEN1 APP

1.56e-06244220307581
Pubmed

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244211880515
Pubmed

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244221513747
Pubmed

Aerobic exercise combined with antioxidative treatment does not counteract moderate- or mid-stage Alzheimer-like pathophysiology of APP/PS1 mice.

PSEN1 APP

1.56e-06244223827013
Pubmed

A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244232857763
Pubmed

Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP mice.

PSEN1 APP

1.56e-06244219135431
Pubmed

Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.

PSEN1 APP

1.56e-06244211520121
Pubmed

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

PSEN1 APP

1.56e-06244217573346
Pubmed

Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention.

PSEN1 APP

1.56e-06244227388605
Pubmed

Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease.

PSEN1 APP

1.56e-06244225281826
Pubmed

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice.

PSEN1 APP

1.56e-06244215748844
Pubmed

Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism.

PSEN1 APP

1.56e-06244234842276
Pubmed

Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease.

PSEN1 APP

1.56e-06244219077180
Pubmed

Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease.

PSEN1 APP

1.56e-06244218317569
Pubmed

Cerebellar amyloid-β plaques: disturbed cortical circuitry in AβPP/PS1 transgenic mice as a model of familial Alzheimer's disease.

PSEN1 APP

1.56e-06244222561329
Pubmed

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model.

PSEN1 APP

1.56e-06244233255764
Pubmed

Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

PSEN1 APP

1.56e-06244230529693
Pubmed

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

PSEN1 APP

1.56e-06244219924286
Pubmed

Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244211493021
Pubmed

Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice.

PSEN1 APP

1.56e-06244218974993
Pubmed

Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

PSEN1 APP

1.56e-06244215261108
Pubmed

Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.

PSEN1 APP

1.56e-06244219936202
Pubmed

Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.

PSEN1 APP

1.56e-06244215087467
Pubmed

Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease.

PSEN1 APP

1.56e-06244215927307
Pubmed

Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.

ZRSR2P1 ZRSR2

1.56e-06244235198906
Pubmed

Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice.

PSEN1 APP

1.56e-06244220970889
Pubmed

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease.

PSEN1 APP

1.56e-06244222393443
Pubmed

Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.

PSEN1 APP

1.56e-06244211476589
Pubmed

Combination therapy prevents amyloid-dependent and -independent structural changes.

PSEN1 APP

1.56e-06244221257234
Pubmed

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.

PSEN1 APP

1.56e-06244231416668
Pubmed

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

PSEN1 APP

1.56e-06244211102478
Pubmed

Transgenic animals relevant to Alzheimer's disease.

PSEN1 APP

1.56e-06244210193895
Pubmed

Novel behavioural characteristics of female APPSwe/PS1ΔE9 double transgenic mice.

PSEN1 APP

1.56e-06244224315833
Pubmed

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.

PSEN1 APP

1.56e-06244212119298
InteractionPAX6 interactions

ZBTB9 ZNF462 APP SRCAP ARID1A ZHX1 EPB41L2

1.32e-05366447int:PAX6
InteractionGNG2 interactions

MYC PLEKHG5 STK26 KCTD17

1.93e-0573444int:GNG2
InteractionHNF4A interactions

ZBTB9 ZNF462 PPARGC1B SRCAP ARID1A ZHX1

2.79e-05275446int:HNF4A
InteractionC8orf33 interactions

MYC APP ZRSR2 HAP1 ZC3H8

3.08e-05167445int:C8orf33
InteractionCES2 interactions

APP STK24 STK26

4.61e-0532443int:CES2
InteractionNUP43 interactions

ZBTB9 ZNF462 TIMELESS UTP3 SRCAP ARID1A ZHX1 ZNF316

5.41e-05625448int:NUP43
InteractionPOLD3 interactions

MYC TIMELESS POLE3 APP

6.15e-0598444int:POLD3
InteractionSNRNP40 interactions

MYC ZBTB9 ZNF462 UTP3 APP ARID1A EPB41L2 ZNF316

6.18e-05637448int:SNRNP40
InteractionGSAP interactions

PSEN1 APP

9.72e-057442int:GSAP
InteractionZNF33B interactions

HAP1 ZHX1

9.72e-057442int:ZNF33B
InteractionFTL interactions

MYC ZBTB9 SRCAP ALMS1 TPRN TTLL5

1.03e-04348446int:FTL
InteractionMAGEB2 interactions

MYC DCAF11 UTP3 PSEN1 ZC3H8 PWP2

1.05e-04349446int:MAGEB2
InteractionPOLR1E interactions

MYC ZBTB9 ZNF462 UTP3 SRCAP PWP2

1.06e-04350446int:POLR1E
InteractionPSMD11 interactions

MYC DCAF11 APP HAP1 ZHX1 STK26

1.11e-04353446int:PSMD11
InteractionLUC7L2 interactions

MYC APP ANKHD1 ZRSR2 HAP1 STK24

1.11e-04353446int:LUC7L2
InteractionNUCKS1 interactions

TIMELESS POLE3 SRCAP ARID1A ERICH6

1.14e-04220445int:NUCKS1
InteractionTSPYL1 interactions

ZBTB9 APP HAP1 CCDC136

1.18e-04116444int:TSPYL1
InteractionNOB1 interactions

MYC DCAF11 APP ANKHD1

1.18e-04116444int:NOB1
InteractionKAT5 interactions

MYC BRPF3 APP SRCAP HAP1 CCDC136

1.20e-04358446int:KAT5
InteractionZBTB9 interactions

MYC ZBTB9 PPARGC1B ZFY

1.22e-04117444int:ZBTB9
InteractionDCAF7 interactions

MYC BRPF3 TIMELESS DCAF11 APP PWP2

1.40e-04368446int:DCAF7
InteractionINIP interactions

MYC APP GTF3C6

1.57e-0448443int:INIP
InteractionZRSR2P1 interactions

ZRSR2P1 ZRSR2

1.66e-049442int:ZRSR2P1
InteractionALDH7A1 interactions

MYC UBA5 APP STK24

1.73e-04128444int:ALDH7A1
InteractionSLC4A1AP interactions

MYC APP ZRSR2 STK26

2.01e-04133444int:SLC4A1AP
InteractionZCRB1 interactions

MYC ZRSR2P1 ZRSR2 ZC3H8

2.06e-04134444int:ZCRB1
InteractionPIPSL interactions

ZBTB9 SRCAP ALMS1 TPRN TTLL5

2.14e-04252445int:PIPSL
InteractionTRMT2A interactions

MYC DCAF11 APP KCTD17

2.37e-04139444int:TRMT2A
InteractionC4orf19 interactions

STK24 STK26

2.53e-0411442int:C4orf19
InteractionSLC32A1 interactions

AXDND1 APP

2.53e-0411442int:SLC32A1
InteractionRBM4B interactions

MYC UTP3 APP STK24 STK26

2.57e-04262445int:RBM4B
InteractionPROSER2 interactions

APP STK24 STK26

2.62e-0457443int:PROSER2
InteractionERN1 interactions

MYC UBA5 PSEN1

2.62e-0457443int:ERN1
InteractionNR1H3 interactions

MYC PPARGC1B APP

2.76e-0458443int:NR1H3
InteractionPDCD7 interactions

APP ZRSR2 HAP1

2.90e-0459443int:PDCD7
InteractionABT1 interactions

MYC UTP3 APP ZC3H8 CCDC136 ZNF316

2.97e-04423446int:ABT1
InteractionNECAB3 interactions

MYC APP

3.03e-0412442int:NECAB3
InteractionENOSF1 interactions

MYC PWP2

3.03e-0412442int:ENOSF1
InteractionZFY interactions

ZBTB9 ZFY

3.03e-0412442int:ZFY
InteractionBRD8 interactions

MYC BRPF3 SRCAP STK26

3.10e-04149444int:BRD8
InteractionDCAF8 interactions

MYC DCAF11 APP EPB41L2

3.26e-04151444int:DCAF8
InteractionKAT7 interactions

MYC BRPF3 APP HAP1

3.34e-04152444int:KAT7
InteractionCTTNBP2 interactions

STK24 CCDC136 STK26

3.36e-0462443int:CTTNBP2
GeneFamilyZinc fingers CCCH-type

ZRSR2P1 ZRSR2 ZC3H8

3.17e-053532373
GeneFamilyAdenylate kinases

AK9 AK7

1.08e-049322356
GeneFamilyTubulin tyrosine ligase family

TTLL12 TTLL5

2.73e-0414322779
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX2 ZHX1

3.14e-0415322529
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

STK24 STK26

5.65e-04203221371
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZBTB9 ZNF462 ZFHX2 ZHX1 ZFY ZNF316

1.44e-0371832628
GeneFamilyRNA binding motif containing

ZRSR2P1 PPARGC1B ZRSR2

6.22e-03213323725
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Lpl-Cadm2_(Layer_2/3,_Cadm2+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AK9 LRRC43 AK7

1.46e-0548443bbfc33299ea8e6895dd4d21a7dd38bec33563127
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTLL12 PPARGC1B ALMS1 STK26

2.01e-051634444af92b211d12c5b88b65bb746242cd702b545bd0
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTLL12 PPARGC1B ALMS1 STK26

2.01e-05163444d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

UBA5 ZRSR2P1 AK9 AK7

2.01e-051634446c4d4c55fc8a731acca13c1ba7287f238a9d81e0
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TTLL12 PPARGC1B ALMS1 STK26

2.37e-05170444bda900c836e0f2c1d7b442beb50b672d025b2420
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TTLL12 BRPF3 STK26 PWP2

2.43e-05171444f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|normal_Lymph_Node / Location, Cell class and cell subclass

PPARGC1B APP ANKHD1 TTLL5

2.72e-05176444476794ef75ce5ab732d78cfeb4944e2f841e3e92
ComputationalNeighborhood of ZNF198

ZNF462 BRPF3 ARID1A ZHX1

1.66e-04117264GCM_ZNF198
DiseaseEarly-onset autosomal dominant Alzheimer disease

PSEN1 APP

4.13e-057422cv:CN043596
DiseaseAlzheimer disease

PSEN1 APP

5.51e-058422cv:C0002395
DiseaseAmyloidosis

PSEN1 APP

8.84e-0510422C0002726
Diseaseurolithiasis

STK24 EPB41L2 PDILT

1.00e-0463423MONDO_0024647
Diseasecerebral cavernous malformation (implicated_via_orthology)

STK24 STK26

1.08e-0411422DOID:0060669 (implicated_via_orthology)
Diseasespecific language impairment, dyslexia

STK24 CCDC136

1.29e-0412422EFO_0005424, EFO_1001510
DiseaseBurkitt Leukemia

MYC ARID1A

2.05e-0415422C4721444
DiseaseAfrican Burkitt's lymphoma

MYC ARID1A

2.05e-0415422C0343640
DiseaseSplenomegaly

PSEN1 APP

4.49e-0422422C0038002
Diseasemethionine measurement

AXDND1 ANKHD1

6.29e-0426422EFO_0009771
DiseaseDevelopmental Academic Disorder

PSEN1 APP

7.84e-0429422C1330966
DiseaseLearning Disorders

PSEN1 APP

7.84e-0429422C0023186
DiseaseLearning Disturbance

PSEN1 APP

7.84e-0429422C0751263
DiseaseAdult Learning Disorders

PSEN1 APP

7.84e-0429422C0751262
DiseaseLearning Disabilities

PSEN1 APP

7.84e-0429422C0751265
DiseaseHematopoetic Myelodysplasia

MYC ZRSR2

7.84e-0429422C2713368
DiseaseBurkitt Lymphoma

MYC ARID1A

1.21e-0336422C0006413
DiseaseCognition Disorders

PSEN1 APP

1.35e-0338422C0009241
DiseaseDegenerative Diseases, Central Nervous System

PSEN1 APP

1.42e-0339422C0270715
DiseaseDegenerative Diseases, Spinal Cord

PSEN1 APP

1.42e-0339422C0751733
DiseaseNeurodegenerative Disorders

PSEN1 APP

1.42e-0339422C0524851

Protein segments in the cluster

PeptideGeneStartEntry
EEEEVVEEELVGEEQ

ERICH6

51

Q7L0X2
VEVAEEEEVAEVEEE

APP

226

P05067
NVDDVVVVEEVEEEA

ALMS1

36

Q8TCU4
EEEEEVEEEEQEAQG

BRPF3

421

Q9ULD4
DIEIIPIQEEEEEET

MS4A1

261

P11836
EEEELEEEEEVLEEN

CCER1

336

Q8TC90
EEEEEVLEENEQRGE

CCER1

341

Q8TC90
LQESQEEEEEEEEEM

P3H3

691

Q8IVL6
EEEEEVVENDEEIAF

ARID1A

1776

O14497
TIREEQEYEEEVEEE

EPB41L2

766

O43491
EEEEEEDEDVDLAQV

DCAF11

31

Q8TEB1
EERLEEEEQNEEEEV

POLE3

131

Q9NRF9
QQQEEEVEEVEVEQV

KCTD17

221

Q8N5Z5
EVEEVEVEQVQVEAD

KCTD17

226

Q8N5Z5
QDEREVKEEEEQQEE

AXDND1

981

Q5T1B0
EEEQEEEEAEEDLQC

HAP1

276

P54257
QQEAEEEEREEEEEA

UTP3

151

Q9NQZ2
EVVEDVIEDIVEEVT

LRRC43

381

Q8N309
VEQNEVIEEEVLAEE

PDILT

506

Q8N807
QTEAEVDEELEEEEE

AK9

901

Q5TCS8
EDGEDEEEEEQLVLV

GTF3C6

11

Q969F1
QVVEQDEEEDEELTL

PSEN1

61

P49768
EAEDEIEDIQQEITV

STK24

71

Q9Y6E0
DLEEAEDEIEDIQQE

STK26

56

Q9P289
DSEEEQEDEEEIDVV

MYC

251

P01106
LQQQEEEDEEEEEEE

PPARGC1B

426

Q86YN6
EEDDEETIEVEEQQE

SRCAP

296

Q6ZRS2
EEEEEEVEEEEEQVQ

CCDC136

21

Q96JN2
EEENDEDVEQEVPIE

ANKHD1

1491

Q8IWZ3
LQSLEEEEDEQEEEE

PLEKHG5

701

O94827
EEEEEEEELQVVQVS

TIMELESS

671

Q9UNS1
EEEVEEEEVEEEQGL

ZFHX2

1711

Q9C0A1
EVIQEEEEIIHEDNE

UBA5

326

Q9GZZ9
LLQREEEEEEEEDQE

PWP2

236

Q15269
LFEENEEEDEVIDDQ

ZHX1

831

Q9UKY1
QVEEVEEEEDEAARE

TTLL12

71

Q14166
VLQIQVEEEEEEEED

ZBTB9

206

Q96C00
VQEVEEEEEEIVVEE

ZNF316

41

A6NFI3
SLEQEEEVDQQEEEE

TPRN

596

Q4KMQ1
AVINVEDDEEEEEDN

ZNF462

716

Q96JM2
EEEDNEVEIEVELDR

ZNF462

726

Q96JM2
EEEEDTFIEEQQLEE

ZRSR2P1

51

Q15695
EEEEDTFIEEQQLEE

ZRSR2

46

Q15696
EEEEEVALDNEDEEQ

TTLL5

586

Q6EMB2
QDVVEDVVIEEDVQC

ZFY

66

P08048
IDDEIDTEVEETQEE

ZC3H8

26

Q8N5P1
EEEEEEENVEDAQEL

AK7

426

Q96M32